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1

2 FPD FPD X

3 X

4 X FPD X CAD

5 X FPD X CAD X

6 X 1970 Autofluoroscope Toffolo RR, et al. The autofluoroscope and 133-Xe in dynamic studies of pulmonary perfusion and ventilation. Radiology, 94; ,1970.

7 X Fluorodensimetry Video densitmetory George RB, et al. Fluorodensimetry. A method for analyzing regional ventilation and diaphragm function. JAMA, 217; , 1971.

8 X 1980 I.I.-X TV Silverman NR, et al. Clinical video-densitometry. Pulmonary ventilation analysis. Radiology, 103; , 1972.

9 X

10 X FPD

11 FPDによるX線動画像の取得 X-ray X-ray X線の減弱 光 電気信号 デジタル画像

12

13 FPD

14 X FPD X CAD

15 SONIAL VISION Safire Shimadzu Japan

16 RIS DICOM

17 110 V, 80mA, 6.3msec 1.5m 7.5 fps 60 frames 1.2 mgy IAEA X 1.5 G [ ] International basic safety standards for protection aginst ionizing radiation and for the safety of radiation sources, (International atomic energy agency (IAEA), vienna, 1996)

18

19 65, x m 16bits Gray-scale 0

20 X FPD X CAD

21

22 X

23 1 10 3

24 COPD cm 1.2cm

25 COPD [ ] Suga K, et al. Impaired respiratory mechanics in pulmonary emphysema: evaluation with dynamic breathing MRI. J Magn Reson Imaging. 1999;10(4):

26 CTR a a b b CTR= a/b 100= 48% CTR = a/b 100 = 64% >50%

27

28 3 1 R. Tanaka, et al: Automated analysis for the respiratory kinetics with the screening dynamic chest radiography using a flat-panel detector system. CARS2003, Proc

29 1/2 1/2 1/2 1/2 1/2 1/2 1/2 1/2 R. Tanaka, et al.:computerized methods for determining respiratory phase on dynamic chest radiographs obtained by a dynamic flat-panel detector system. J Digit Imag,2006;9(1): R. Tanaka, et al.:breathing Chest Radiography using a Dynamic Flat-Panel Detector (FPD) with Computer Analysis for a Screening Examination. Med Phys, 2004;31(8):

30 msec mm (mm)

31

32

33 Systole Expiration Diastole Inspiration Citation from L. F. Squire and R. A. Novelline, Overexpansion and Collapse of the Lung. In: Fundamentals of Radiology, 4th ed. pp

34

35 X RI 26(1);13-16, 2009

36

37 Systole Expiration Diastole Inspiration Citation from L. F. Squire and R. A. Novelline, Overexpansion and Collapse of the Lung. In: Fundamentals of Radiology, 4th ed. pp

38

39

40 Systole Expiration Diastole Inspiration

41

42 X FPD X CAD

43

44

45

46

47

48

49

50 255 0

51 +7.5% -7.5% X,

52

53 50 (=0.01%) 0

54 X Down ( - ) ( - ) ( - ) UP

55 +10 X Down -10 X Up R T

56 X FPD X CAD

57 X CAD X

58 X CAD 1.5% r=0.01 r=0.70 0

59 X CAD 1.5% r=0.01 0

60 X CAD 2.0% r=0.40 0

61 R Tanaka, S Sanada, M Fujimura, et al. Development of computeraided diagnosis system for functional evaluation on breathing chest radiographs: Preliminary study. IJCARS, 2010(In press) X CAD

62 X FPD X CAD

63

64 R. Tanaka, S. Sanada, N. Okazaki, et al: Evaluation of pulmonary function using breathing chest radiography with a dynamic flat-panel detector (FPD): Primary results in pulmonary diseases. Invest Radiol, 41(10), , 2006

65 X

66 RI

67 RI

68 15 COPD, (31-75 years old; 3 Female, 7 Male;) 10 (21 51 years old; mean, 25.8 years old; M:F=7:3)

69 COPD SBS+ VC

70 CT COPD SBS+

71 COPD SBS+

72 COPD SBS+

73 COPD SBS+

74 COPD SBS+

75 COPD SBS+

76 COPD SBS+

77 COPD SBS+

78 COPD 52 VC

79 CT COPD 52

80 COPD 52 Ventilation Perfusion

81 COPD 52

82 COPD 52

83 COPD 52

84 COPD 52 r 0.74

85 74 VC

86 74 Ventilation Perfusion

87 RI V/Q

88 V/Q

89 RI V/Q V/Q RI X - mismatch V/Q study 26(3) 68-72, 2009

90 74 V/Q PV r=0.78 V/Q RI

91 COPD RI V/Q study

92 RI

93

94 CAD)

95 X

96

97

98

99

100

101

102

103 FPD

104

105 Sholder Temporomandibular Joint Chest Cervical spine Heart Hand Knee

106

107

108 1. & 2. CAD

109

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_02.indd 30, 11-16, 2010 Z Z score Computed tomography ROC analysis 3 CT 1,2 CT 1/3 3 5 CT CT 6 7,8 MCA ASPECTS Alberta Stroke Programme Early CT Score 4 10 CT ASPECTS 50% 9 Z 10 CT Z CT 10 Z Z Z receiver operating

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