} 無 アル ブミンラ ッ ト肝細 胞 への分離正常 肝細胞の移植 r一 昭和63年 度 科学 研究黄補 助金(一 般C>研 究成果報告書 ハ 平成元年3月 研究代表者 小川 勝洋 (旭 川医科 大学医学部教授)
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1 } 無 アル ブミンラ ッ ト肝細 胞 への分離正常 肝細胞の移植 r一 昭和63年 度 科学 研究黄補 助金(一 般C>研 究成果報告書 ハ 平成元年3月 研究代表者 小川 勝洋 (旭 川医科 大学医学部教授)
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7 1) Mito, M., Ebata, H., Kusano, M., Onishi, Y., Saito, T., Sakamoto, S. : Morphology and function of isolated hepatocytes transplanted into rat spleen. Transplantation 28: , ) Rao, M. S., Thorgeisson, S., Reddy, M. K., Lalwani, N. D., Evarts, R. E., Usman, M. I., Singh, B., Reddy, j. K. : Induction of peroxisome proliferation in hepatocytes transplanted into the anterior chamber of the eye. A model system for the evaluation of xenobioticinduced effects. Am. j. Pathol. 124: , ) Demetriou, A. A., Whiting, j. F., Feldman, D., Levenson, S. M., Choudhurg, N. R., Mosciomi, A. D., Kram, M., Choudhurg, j. R. : Replacement of liver function in rats by transplantation of microcarrier-attached hepatocytes. Science 233: , ) jirtle, R. L., Michalopoulos, G. : A clonal assay in vivo parenchymal hepatocytes. In: Cell Clones: Manual of Mammalian Cell Techniques, C. S. Potten & j. H. Hendry (Eds.) Churchill Livingstone, Edin, London, Melbourne & N. Y. p , ) Matas, A., Sutherland, D. E. R., Steffes, M. W., Mauer, S. M., Lowe, A., Simmons, R. L., Najarian, j. S. : Hepatocellular transplantation for metabotic deficiencies: decrease of plasma filirubin in Gunn rats. Science 192: , 1976
8 6) Groth, C. G., Arborgh, B., Bjorken, C., Sundberg, B., Lundgrem, G. : Correction of hyperbilirubinemia in the glucuromyl-transferasedeficient rat by intraportalhepatocyte transplantation. Transplant. Proc. 9: , ) Sommer, B. G., Sutherland, D. E., Matas, A. J., Simmons, R. L., Najarian, J. S. : Hepatocellular transplantation for treatment of D-galactosamini-induced acute liver failure in rats. Transplant. Proc. 11: , ) Makowka, L., Falk, R. E., Rotstein, L. E., Falk, J. A., Nossal, N., Langer, B., Blendis, L. M., Phillips, M. J. : Cellular transplantation in the treatment of experimental hepatic failure. Science 210: , ) Makino, R., Sato, S., Esumi, H., Negishi, C., Takano, M., Sugimura, T., Nagase, S., Tanaka, H. : Presence of albumin positive cells in the liver of analbuminemic rats and their increase on treatment with hepatocarcinogens. Gann 77: , ) Hart, T. K., Pino, R. M. : Psendoislet vascularization. Induction of diaphragmfenestrated endothelia from the hepatic sinusoids. Lab. Invest. 54: , ) Nicoison, G. L. : Cancer metastasis. Organ colonization and the cell-surface properties of malignant cells. BBA. 695: , ) Martinetz-Hernandez, A. : The hepatic extracellular matrix. : I. Electron immunohistochemical studied rat liver. Lab. Invest. 51: 57-74, 1984
9 13) Ledley, F. D. : Somatic gene therapy for human disease. : Background and prospects. Part 1. J. Pediat. 110: 1-8, ) Peng, H., Armentano, D., Darlington, G., Ledley, Mackenzie-Graham, F., Woo, S. L. C. : L., Shen, R. F., Retrov i ra l -med i ated gene transfer and expression of human phenyl an i me hydroxylose in primary mouse hepatocytes. Proc. Natl. Acad. Sci. 85: , ) Yokota, K., Ogawa K. genotypic marker of transplanted within, Mori, M., Nagase, S. : Lack of albumin as preneoplastic analbuminemic rat hepatocytes albumin-postive liver. Cancer Res. 48: , 1988
1. Sugimura, T. and Fujimura, S.: Tumor production in glandular stomach of rat by N-methyl-N'-nitro- N-nitrosoguanidine. Nature, 216, 943-944, 1967. 2. Fujimura, S., Kogure, K., Sugimura, T. and Takayama,
Various function and toxicity of iron Key words 1) Hentze, M. W. et al: Cell, 117, 285-297 (2004) 2) Ganz, T.: Blood, 102, 783-788 (2003) 3) Nemeth, E. et al.: Science, 306, 2090-2093 (2004) 4) Hentze,
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1) van Meer, G., Op den Kamp, J. A.: J. Cell. Biochem., 19, 193-2040982) 2) Gaffet, P., Bettache, N., Bienvenue, A.: Biochemistry, 34, 6762-6769(1995) 3) Sims, P. J., Wiedmer, T.: Thromb. Haemost., 86,
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