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1 VOL33NO.3/2010

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14 A B p-erk1/2 Time (min) Erk1/2 Time (min) p-vasp VASP C D enos/gapdh x-fold vs sham * 0 ANP (-) (+) (-) (+) PD98059 (-) (-) (+) (+) enos/gapdh x-fold vs sham ANP sirna (-) (+) (-) (+) (-) (-) (+) (+) VEGF/GAPDH x-fold vs sham * 0 ANP (-) (+) (-) (+) PD98059 (-) (-) (+) (+) VEGF/GAPDH x-fold vs sham ANP sirna (-) (+) (-) (+) (-) (-) (+) (+)

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16 N Engl J Med J Clin Invest Curr Opin Nephrol Hypertens Circulation Circulation Proc Natl Acad Sci USA Endocrinology Arterioscler Thromb Vasc Biol Am J pathol Biochem Biophys Res Commun Endocrinology Nat Med Circ Res J Clin Invest Endocrinology

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26 prepro ET-1 pro ET-1 big ET-1 ECE ET A ET-1 ET-1 ET B ET B L-Arg enos NO

27 ET A ET-1 ET B ET B ET A ET-1 ET B

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2007050781......_.L.O...z.W

2007050781......_.L.O...z.W a s d f g a s d f g h j k l 0 in vitro in vivo in vitro in vivo in vivo in vivo in vitro Metabolism Metabolism Endocr Endocr Endocrinol Ann NYA cad Sci J clin Endocr Metab

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1) van Meer, G., Op den Kamp, J. A.: J. Cell. Biochem., 19, 193-2040982) 2) Gaffet, P., Bettache, N., Bienvenue, A.: Biochemistry, 34, 6762-6769(1995) 3) Sims, P. J., Wiedmer, T.: Thromb. Haemost., 86,

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drug development Toshimi Michigami, E-mail : michigami@mch.pref.osaka.jp Keiichi Ozono, E-mail : keioz@ped.med.osaka-u.ac.jp The progress in the research on vitamin D 1) McCollum, E. V. et al.:

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