日本語プログラム110916_修正hiro110918

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14 P131 P132 P133 P134 P135 P136 P137 P138 P139 Maternal Exposure to Simazine Inhibits Relaxin Signaling Pathway and Elicits Reproductive Toxicity in Male Mice Offspring Ho-Oak Park 1, Mira Park 1, Ji-Yoo Han 2, Jeong-Jae Ko 2, Woo-Sik Lee 3, Tae Ki Yoon 3, Kangseok Lee 4, and Jeehyeon Bae 1 * ( 1 Department of Pharmacy & 2 Biomedical Science, CHA University, 3 Fertility Center of CHA Gangnam Medical Center, 4 Department of Life Science, College of Natural Science, Chung-Ang University) The positive role of Fgr kinase in the activation of mast cells and anaphylaxis Young Mi Kim 1, Ki Hwa Jung 1, Do Kyun Kim 2, Hyuk Soon Kim 2, and Wahn Soo Choi 2 ( 1 College of Pharmacy, Duksung Women s University, 2 College of Medicine, CBITRC, Konkuk University) Studies on Acute Hepatotoxicity Study of Foeniculum vulgare Da Eun Sur, Yeo Jin Kang, Se Young Choung (Department of Fundamental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) Oral Administration of KPH- 001 Extract Alleviates DNCB- Induced Atopic Dermatitis in NC/Nga Mice Kim Min Ju, Kang Hyun Kim, Se Young Choung (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University)

15 P140 P141 P142 P143 P144 P145 P146 P147 The Preventive Effects of KPH- 002 Extract on Age- Related Macular Degeneration Sun Myung Yoon, Sun Mi Kim, Se Young Choung (Department of Life and Nanopharmaceutical Science of Pharmacy, Kyung Hee University) Doxorubicin- induced Platelet Procoagulant Activities: An Important Clue for Chemotherapy- Associated Thrombosis Se-Hwan Kim, Kyung-Min Lim, So-Youn Kwon and Jin-Ho Chung (College of Pharmacy, Seoul National University) Procoagulant and Prothrombotic effects of herbal medicine, Dipsacus asper on human platelets Ji-Seon Song, Kyung-Min Lim, So-Jin Park and Jin-Ho Chung (College of Pharmacy, Seoul National University) Safety Evaluation of Herbal Medicines: Procoagulant Activation by Herbal Extracts in Platelets Keunyoung Kim, Ji-Seon Song, Yoon-Kyung Heo and Jin-Ho Chung (College of Pharmacy, Seoul National University) Safety Evaluation of Herbal Medicines: Vascular Dysfuction by Herbal Extrats Keunyoung Kim, Seojin Kang and Jin-Ho Chung (College of Pharmacy, Seoul National University) Potentiation of vasoconstriction and pressor response by low concentration of monomethylarsonous acid (MMA III ) Kyung-Min Lim, Yoo-Sun Shin, Youn-Kyeong Chang, and Jin-Ho Chung (College of Pharmacy, Seoul National University) Effects of puerarin on endothelial nitric oxide synthase activation through estrogen receptor- dependent PI3- kinase and calcium- dependent AMP- activated protein kinase Yong Pil Hwang 1, Hyung Gyun Kim 1, Myung Ho Jeong 2, Bong-Hee Kim 1, Sang Kyum Kim 1, Hye Gwang Jeong 1,* ( 1 Department of Toxicology, College of Pharmacy, Chungnam National University, 2 Heart Research Center, Chonnam National University Hospital) Inhibitory effect of thymus- and activation- regulated chemokine expression by Pleurotus eryngii in human keratinocytes Eun Hee Han 1, Jae Ho Choi 1, Hyun-Uk Lee 2, Young Chul Chung 3, Hye Gwang Jeong 1 * ( 1 Department of Toxicology, College of Pharmacy, 2 Mushroom Science Research Institute, Mushtopia Co., Ltd, 3 Division of Food Science, Korea International University)

16 P148 P149 P150 P151 P152 P153 Effects of ethyl acetate extract of Psidium guajava on thymus and activation- regulated chemokine expression induced by IFN- γ and TNF- α in human keratinocytes Eun Hee Han 1, Yong Pil Hwang 1, Jae Ho Choi 1, Ji Hye Yang 1, Jong Kwon Seo 2, Young Chul Chung 2, Hye Gwang Jeong 1 ( 1 Department of Toxicology, College of Pharmacy, Chungnam National University, 2 Department of Food Science, College of Public Health and Natural Science, Korea International University) Effects of ethyl acetate extract of Psidium guajava on atopic dermatitis- like skin lesions induced by 2,4- dinitrochlorobenzene in NC/Nga mice Jae Ho Choi 1, Eun Hee Han 1, Bong Hwan Park 1, Hyung Gyun Kim 1, Jong Kwon Seo 2, Young Chul Chung 2, Hye Gwang Jeong 1 * ( 1 Department of Toxicology, College of Pharmacy, Chungnam National University, 2 Department of Food Science, College of Public Health and Natural Science, Korea International University) Effects of saponins extracts from the roots of Platycodon grandiflorum on ovariectomy- induced bone loss Jae Ho Choi 1, Eun Hee Han 1, Bong Hwan Park 1, Kwang Youl Lee 2, Bong-Hee Kim 1, Sang Kyum Kim 1, Hye Gwang Jeong 1 * ( 1 Department of Toxicology, College of Pharmacy, Chungnam National University, 2 College of Pharmacy and Research Institute of Drug Development, Chonnam National University) Effects of acrolein- induced MUC5AC expression by Platycodon grandiflorum root- derived saponin in A549 cells Jae Ho Choi 1, Yong Pil Hwang 1, Eun Hee Han 1, Hyung Gyun Kim 1, Bong Hwan Park 1, Jong Kwon Seo 2, Young Chul Chung 2, Hye Gwang Jeong 1 * ( 1 Department of Toxicology, College of Pharmacy, Chungnam National University, 2 Department of Food Science, College of Public Health and Natural Science, Korea International University) Effects of transforming growth factor- β1- induced epithelial to mesenchymal transition by Platycodon grandiflorum root- derived saponin in A549 cells Jae Ho Choi 1, Eun Hee Han 1, Yong Pil Hwang 1, Young Chul Chung 2, Hye Gwang Jeong 1 * ( 1 Department of Toxicology, College of Pharmacy, Chungnam National University, 2 Department of Food Science, College of Public Health and Natural Science, Korea International University) Metabolism of arbutin by human intestinal microflora and its cytotoxic effect Hyung Gyun Kim 1, Tilak Khanal 1, Tae Cheon Jeong 2, Hye Gwang Jeong 1 ( 1 College of Pharmacy, Chungnam National University, 2 College of Pharmacy, Yeungnam University)

17 P154 Effects of anthocyanins from purple sweet potato against tert- butyl hydroperoxide- induced hepatotoxicity Yong Pil Hwang 1, Jae Ho Choi 1, Jun Min Choi 2, Young Chul Chung 2, Hye Gwang Jeong 1 * ( 1 Department of Toxicology, College of Pharmacy, Chungnam National University, 2 Department of Food Science, College of Public Health and Natural Science, Korea International University) P155 P156 P157 P158 P159 P160 Effects of anthocyanins from purple sweet potato on hepatic lipid accumulation through activating AMP- activated protein kinase in human HepG2 cells and obese mice Yong Pil Hwang 1, Jae Ho Choi 1, Eun Hee Han 1, Hyung Gyun Kim 1, Ji-Hyang Wee 2, Kyung Ok Jung 2, Kyung Hee Jung 2, Hye Gwang Jeong 1 * ( 1 Department of Toxicology, College of Pharmacy, Chungnam National University, 2 Jeonnam Bioindustry Foundation, Biofood Technology Center) COX- 2 expression induced by 1- Bromopropane in murine macrophages Eun Hee Han 1, Jae Ho Choi 1, Ji Hye Yang 1, Kwang Youl Lee 2, Tae Cheon Jeong 3, Bong-Hee Kim 1, Sang Kyum Kim 1, Hye Gwang Jeong 1 * ( 1 Department of Toxicology, College of Pharmacy, Chungnam National University, 2 College of Pharmacy and Research Institute of Drug Development, Chonnam National University, 3 College of Pharmacy, Yeungnam University) Homocysteine level modulation in Goto- Kakizaki rats Kang Uk Yun 1 *, Young Suk Jung 2, Hui Chan Kwak 1, Bong-Hee Kim 1, Sang Kyum Kim 1 ( 1 College of Pharmacy, Chungnam National University, Korea, 2 Department of Pathology, Wayne State University, School of Medicine, USA) Hepatic expression of cytochrome P450 in type 2 diabetic Goto- Kakizaki rats Jong Min Choi, Gwan Ho Lee, Kang Uk Yun, Jung Min Oh, Hui Chan Kwak, Kye Sook Lee, Bong Hee Kim, and Sang Kyum Kim (College of Pharmacy, Chungnam National University) Sirtinol, a class III HDAC inhibitor, induces apoptotic cell death in human breast cancer MCF- 7 cells Jing Wang, Tae Hyung Kim, Umasanka De, Young Ju Lee, A Jin Won, Hyung Sik Kim* (College of Pharmacy, Pusan National University) A histone deacetylase inhibitor, SAHA induces autophagy cell death in tamoxifen- resistant MCF- 7 human breast cancer cells Young Ju Lee, Tae Hyung Kim, Umasanka De, A Jin Won, Jing Wang, Hyung Sik Kim (College of Pharmacy, Pusan National University)

18 P161 P162 P163 P164 P165 P166 P167 P168 Identification of urinary biomarkers for nephrotoxicity via NMR- based metabolites in Sprague- Dawley rats Tae Hyung Kim 1, Umasanka De 1, Young Ju Lee 1, A Jin Won 1, Jing Wang 1, Byung Mu Lee 2, Suk Man Kim 3, Hyung Sik Kim 1 * ( 1 College of Pharmacy, Pusan National University, 2 College of Pharmacy, Sungkyunkwan University, 3 Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University) Cisplatin induces autophagy cell death via SIRT1 expression in human kidney proximal tubular HK- 2 cells Tae Hyung Kim, Umasanka De, Young Joo Lee, Ar Jin Won, Jing Wang, and Hyung Sik Kim* (College of Pharmacy, Pusan National University) Hepatic sulfur amino acid metabolism in high fat fed C57BL/6 mice Kang Uk Yun 1 *, Bong-Hee Kim 1, Chul-Ho Lee 2, Hyun-Sun Lee 3, Sang Kyum Kim 1 ( 1 College of Pharmacy, Chungnam National University, 2 Laboratory of Experimental Animals, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 3 Molecular Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)) Homocysteine levels are decreased in db/db mice Kang Uk Yun 1 *, Bong-Hee Kim 1, Chul-Ho Lee 2, Hyun-Sun Lee 3, Sang Kyum Kim 1 ( 1 College of Pharmacy, Chungnam National University, 1 Laboratory of Experimental Animals, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 3 Molecular Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)) Antioxidant capacity against hydroxyl radical, peroxyl radical, and peroxynitrite of extracts and active components from selected medicinal plants Do Young Kwon, Chul Won Ahn, Ji Hyun Kim, Yoo Min Lee, Young Chul Kim (College of Pharmacy, Seoul National University) Metabolomic analysis of sulfur- containing substances and polyamines in regenerating rat liver Sun Ju Kim, Seung Mok Park, Doo Sung Jun, Young Chul Kim (College of Pharmacy, Seoul National University) Preventive effect of betaine supplementation against induction of non- alcoholic fatty liver in rats Chul Won Ahn, Do Young Kwon, Sun Ju Kim, Jung Ah Lee, Young Chul Kim (College of Pharmacy, Seoul National University) Effects of medicinal herbs and their components on the steatogenic hepatotoxicity Se-Hee Oh, You-Jin Choi, Ho-Sung Choi, So-Ra Park, Byung-Hoon Lee*( College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University)

19 P169 P170 P171 P172 Toxicity Screening of Drug- induced Phospholipidosis Sora Park, Woo-cheol Shim, Yujin Yoon, Kang-yo Lee, Byung-Hoon Lee* (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) Effects of Chaga Mushroom (Inonotus Obliquus) Extracts on the Production of Cytokines in RBL2H3 cells, EL- 4 T cells and Raw264.7 cells Suk-Kyung Ko 1,2, Myoung-yun Pyo 1 ( 1 College of Pharmacy, Sookmyung Women s University, 2 Seoul Metropolitan Government Research Institute of Public Health and Environment) Anti- metastasis effect of novel ALK5 inhibitor in both breast cancer cells and 4T1- Luc xenograft mice Son Jee Y, Kim Sol J, Park Sang A, Kim Min J, Kim Seung W, Kim Dae-Kee, Sheen Yhun Yhong (Ewha Womans University, College of Pharmacy) Bioinformatic analysis of prenatal bisphenol A exposure Mihi Yang, Myoung-Yun Pyo (College of Pharmacy, Sookmyung Women s University)