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6 D- D D- D /2004 D-FDA GRAS D D- 3

7 5 5 D g/kg D % D- 5(D mg//) () D g/kg/ 1220g/kg/ 20g/kg/ 1220g/kg/ () 50 D- 10% 4 5g/kg / 24 () % () D g22.5g/3 D- 22.5g/ 1 MCV MCV MCHC 22.5g 22.5g () 4

8 12 D- 15g45/ HDL D- 2 () 8 ( 4 )2 8 ( 4 ) D- 75g/ (25g3 ) D 15g45g/ 45 6 D g D- 30g 22.5g g D- 75g D- 75g OGTT 2 AUC D- 75g OSTT 2 10 D- 1030g D- 75g ()

9 D- 7.5g D- 75g D 75g (OGTT) D D-1- ATP D D--1- ATP 150 D D- 30g () 8 D- 75g/ 2 SU 2 23 SU g -() 1 6

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14 Levin GV, Zehner LR, Saunders JP, Beadle JR. Sugar substitutes: their energy values, bulk characteristics, and potential health benefits. Am. J. Clin. Nutr.(1995) 62: 1161S-8S. FDA. Agency response letter GRAS Notis No.GRN (2001). Joint FAO/WHO expert committee on food additives sixty-third meeting. Summary and conclusions. ftp://ftp.fao.org/es/esn/jecfa/jecfa63_summary.pdf Kruger CL, Whittaker MH, Frankos VH. Genotoxicity tests on D-tagatose. Regulatory Toxicology and Pharmacology (1999)29: S36-S42. Acute Oral Toxicity Study in rats and mice. (1989).() Kruger CL, Whittaker MH, Frankos VH, Trimmer GW. 90day oral toxicity study of D-tagatose in rats. Regulatory Toxicology and Pharmacology(1999) 29: S1-S10. Kruger CL, Whittaker MH, Frankos VH, Schroeder RE. Development toxicity study of D-tagatose in rats. Regulatory Toxicology and Pharmacology(1999) 29: S28-S35. Lina BAR, Kuper CF. Chronic toxicity and carcinogenicity study with D-tagatose and fructose in Wistar ratstno Nutrition and Food Research(2002)4533..(2002),,,,, D-(No.3): 3. (200526: Donner TW, Wilber JF. 1year administration study of D-tagatose in adults with type 2 diabetes. Diabetes, obesity and metabolism. Sauders JP, Donner TW, Sadler JH, Levin GV, Makris NG. Effect of acute and repeated oral doses of D-tagatose on plasma uric acid in normal and diabetic humans. Regulatory Toxicology and Pharmacology.(1999)29:S57-S65. Boesch C, Ith M, Jung B, Bruegger K, Erban S, Diamantis I, Kreis R, Bar A. Effects of oral D-tagatose on liver volume and hepatic glycogen accumulation in healthy male volunteers. Regulatory Toxicology and Pharmacology (2001)33: ,,,,..(2006)27: Donner TW, Wilber JF, Ostrwski D. D-tagatose, a novel hexose : acute effects on carbohydrate tolerance in subjects with and without type 2 diabetes. Diabetes, Obesity and Metabolism. (1999)1: Buemann B, Gesmar H, Astrup A, Quistorff B. Effects of oral D-tagatose, a stereoisomer of D-fructose, on liver metabolism in man as examined by 31P-magnetic resonance spectroscopy. Metabolism(2000)49: D-. (2005)() 2 D-. (2005) () Chiasson JL, Josse RG, Hunt JA, Palmason C, Rodger NW, Ross SA, Ryan EA, Tan MH, Wolever TMS. The efficacy of acarbose in the treatment of patients with non-insulindependent diabetes mellitus. Ann.Intern. Med.(1994)121: Buemann B, Toubro S, Holst JJ, Rehfeld JF, Bibby BM, Astrup A, D-tagatose, a stereoisomer of D-fructose, increases blood uric acid concentration. Metabolism (2000)49:

15 22 Effect of an oral 30g dose of D-tagatose on the plasma uric acid levels of healthy male volunteers. (2001).() 23 Effect of oral 15g dose of D-tagatose on the plasma uric acid levels of hyperuricemic male volunteers. (2002).() 24 Final assessment report application A472, D-tagatose as a novel food. Food Standards Australia New Zealand (2004). 12

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