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1 Core Ethics Vol.

2 Core Ethics Vol. MAO Roland Kuhn DiMascio et al. MAO antidepressants antidepressants tymoleptics analeptic stimulant psychic energizing tymoleptic depressolytic antidepressant DiMascio et al. - Antidepressant Tymoleptica Tymeretica MAO Psychostimulant Psychostimulant MAO MAO MAO

3 psychopharmacology psychotropic drugs - chlorpromazine reserpine phenothiazine butyrophenone imipramine propandiol benzodiazepine chlorpromazine reserpine psychotropic tricyclic antidepressants monoamine oxidase inhibitors B depressive states reserpine

4 Core Ethics Vol. serotonin noradrenaline catecholamine serotonin serotonin

5 B. electroshock therapy, electroconvulsive therapy

6 Core Ethics Vol

7 - -

8 Core Ethics Vol. Wilhelm Griesinger Griesinger Griesinger Emil Kraepelin a SSRI Times Peter Kramer Listening to Prozac enhancement Elizabeth Wurtzel Prozac Nation David Healy Healy SSRI SSRI SSRI Edward Shorter Elliot S Valenstein Healy Shorter Valenstein Healy

9 Healy MAO Imipramine Amitriptyline Desipramine Trimipramine Meritracene Nortriptyline Clomipramine Dibenzepine Dimethacrine Amoxapine Maprotyline Lofepramine Myanserin Dosulepin Setiptiline Trazodone Pheniprazine Phenelzine Nialamide Isocarboxide Safrazine MAO DiMascio et al. ECT electroconvulsive therapy ECT Healy Kramer Wurtzel

10 Core Ethics Vol. Ban Thomas A., Hollender Marc H., Psychopharmacology for Everyday Practice S.Karger AG,Basel. DiMascio Alberto Shader,Richard I., Clinical Handbook of Psychopharmacology New York Science House Inc. Griesinger,WilhelmDie Pathologie und Therapie der psychischen Krankheiten Healy,David, Let Them Eat Prozac: The Unhealthy Relationship between the Pharmaceutical Industry and Depression, James Lorimer & Company SSRI - Kass, Leon R, ed.,, Beyond Therapy: Biotechnology and the Pursuit of Happiness: A Report of The President's Council on Bioethics, New York: Dana Press MAO - - a - b - Kramer Peter D., Listening to Prozac Viking Penguin Inc Core Ethics- b WUP -. Shorter EdwardA History of Psychiatry: From the Era of the Asylum to the Age of Prozac. John Wiley & Sons,Inc. - Valenstein Elliot S.,, Blaming the Brain:The Truth About Drugs and Mental Health a division of Simon & Schuster. Wurtzel ElizabethProzac Nation Houghton Mifflin Core Ethics-

11 The Rise of Antidepressants: Psychiatric Discourse in Japan from the s to the s MATSUEDA Akiko Abstract: This paper examines the changes in psychiatric discourse and practice that led to the spread of antidepressants for the psychiatric treatment of depression. The paper analyzes ( ) the change in psychiatric theory towards a positive evaluation of antidepressants by psychiatrists in medical textbooks in the s and s; ( ) the change in psychiatric practice that occurred with the rise of antidepressants, when psychotropic drugs began to be compared with electric shock treatment; ( ) the influence of Katei No Igaku (Family Medicine), a medical manual which introduced psychiatrists ideas about the causes of and treatments for depression to laypeople. In the s, antidepressants were discovered by chance. In the s, medication was not the dominant psychiatric treatment choice, but, in the s, antidepressants became the main choice for psychiatric treatment. The idea that psychiatric disease originates in the organ of the brain emerged from th century German psychiatry. When psychiatric pharmacology developed, however, there arose a new discourse that psychiatric disease is caused, instead, by biochemical substances within the brain. This removed vague fears of psychiatric disease, because psychiatric drug treatment worked on the substances within a brain disorder and antidepressants treated depression based on biochemical evidence. Keywords: psychotropic drugs, antidepressants, psychiatric discourse, discourse analysis

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