特論1

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1 Bull. Natl. Inst. Health Sci., 124 Special report Preventive Measures against Health Damage due to Chemicals in Household Products 1 ACD m ACD ACD # To whom correspondence should be addressed: Masa-aki Kaniwa; Kamiyoga , Setagaya, Tokyo , Japan; Phone: ; Fax: ; kaniwa@nihs.go.jp

Household Products 1 ACD 1 15 20 m 3 16 14 16 ACD 15 17 ACD # To whom correspondence

2 , No ppm a aa PCB PL ISO 9001 ISO 9002 PRTR

3 SEK SEK SIAA SIAA SEK SIAA 15,17 OECD 1995 ISO ,19 24 Ames 28 SEK Ames 48 Ames SIAA SIAA 16

4 MSDS MSDS PRTR ISO JIS Z MSDS MSDS MSDS MSDS MSDS PL 1995 ACD MSDS MSDS ACD ACD MSDS ACD

20-22 MSDS MSDS 23-24 1994 1991 1999 2000 1995

5 ACD MSDS 2 NACS 3 NACS 1 NACS NACS ACD NACS NACS ACD

3 105 105 100 NACS ACD 34 10 27 20 30 8 22 50 16 6 4 2

6 NACS NACS ACD MSDS 3 MSDS MSDS ACD ACD ACD MSDS ACD

7 ACD ACD as is ICDRG ACD GPMT ACD SFE TLC HPLC SFC TLC HPLC, SFC GC UV IR NMR GC GC MS LC MS ACD -

8 T 1 ACD Immunoglobulin Ig IgE 10 ACD ACD 1 HCHO HCHO 75 ppm 20 1 HCHO 75 ppm HCHO HCHO 4

9 P AS AS D ACD ACD , ACD ACD ACD ACD 1996 ACD ACD 32, ,10 OBPA ACD 2,3,5,6 TCMSP ACD OBPA TCMSP OBPA MSDS OBPA 2 GPMT OBPA GPMT TCMSP MSDS TCMSP ACD

1997 10,10 OBPA ACD 2,3,5,6 TCMSP ACD OBPA TCMSP

10 OBPA TCMSP 1998 a BCA ACD 1987 BCA ACD BCA BCA BCA BCA BCA ACD SEK SIAA 5 1 ACD ACD 6 2 ACD

11 SP 7,58, DTC ACD 2,2-4 6 tert MBMBP 2,2 4,6 IBBDMP SP DTC ACD 5 DTC ZDMC ZDEC ZDBC ZEPC DMA DEA PIP 7,58,62 3 N N p IPPD 3 IPPD N 1,3 N p DMBPPD 6 2,2,4 1,2 ETMDQ IPPD, DMBPPD, ETMDQ IPPD ACD DOD 4 MBT ACD SP 2,6 di tert 4 BHT MBT 2 MBT 2,2 MBTS MBT MBTS DTC ZDMC ZDEC 3 1 ACD 3 MBT MBTS 7,58,63-64,67 ACD MBT MBT GPMT MBT, MBTS S MBT SP 5 ACD

IPPD, DMBPPD, ETMDQ IPPD ACD DOD 4 MBT ACD SP 2,6 di tert 4 BHT MBT 2 MBT 2,2 MBTS MBT

12 ACD ACD DETU 1 DETU DBTUDLTU DPTU GPMT 7,69 6 p tert PTBP FR ACD PTBP FR 1 PTBP FR PTBP FR ACD PTBP FR ACD PTBP FR PTBP FR 9, ACD ACD GPMT IPPD MBT MBTS PTBP FR DTC ZDMC ZDEC ZDBC ZEPC DMA DEA PIP DMBPPD SP 10 ACD ACD ACD ,80

9,58 7 1980 ACD ACD GPMT IPPD MBT MBTS PTBP FR DTC ZDMC ZDEC ZDBC

13 OAS ACD ACD GPMT GPMT ACD Environmental Dermatology MSDS ACD MSDS MSDS 84,

14 VOC % %

15 1978 CPSC CPSC CPSC 16CFR Part CPSC CPSC DIY XRF mm 50 mm 42.7 mm 3 71 CPSC CPSC 175 mg ,90

06 2003 10 15 2003 4 18 1 88 CPSC 2005 2 3 CPSC 2005 5 2006 3 DIY XRF 140

16 MSDS 2000 MSDS MSDS MSDS Evidence Based Communication PL 7

17 1, ACD , , , P tert butylphenol formaldehyde resin ISO MSDS PRTR MSDS MSDS No

23 1999 6 7 7 36 4 5 9 2000 7 18 11 1 37 3 5 13 2001 8 19 12 2 37 4 5 16 2001 9 57 50 P tert butylphenol formaldehyde resin 40 6 5 13 2004 10

18 No DC AS Pigmented contact dermatitis ) 27 Ueda K, Yamamoto Y, Tenjo S et al: Two cases of pigmented contact dermatitis. Environmental Dermatology, 2, (1995) 28 Nakagawa M, Kawai K, Kawai K: Multiple azo disperse dye sensitization mainly due to group sensitization to azo dyes. Contact Dermatitis, 34(1), 6 11 (1996) 29 Tinuin P Arisu K, Hayakawa R, Ogino K et al: Tinuvin P in a spandex tape as a cause of clothing dermatitis, Contact Dermatitis 26, (1992) 31 1 Environ Dermatol 9 Suppl Benzalkonium chloride Kathon CG Alkyldiaminoethylglycine hydrochloride Tego Chlorhexidine gluconate Hibiten No.97 D DP Kathon CG CG PPD Kathon CG KathonCG Benzyl paraben Propyl paraben Damstra RJ, van Vloten WA, van Ginkel CJW: Allergic contact dermatitis from the preservative 1,2 benzimidazolin 3 one (1,2 BIT; Proxel): a case report, its prevalence in those occupationally at risk and in the general dermatological population, and its relationship to allergy to its analogue Kathon CG, Contact Dermatitis 27, (1992) 45 Oleaga JM, Aguirre A, Landa H et al: Allergic contact dermatitis from kathon 893, Contact Dermatitis 27, 345 (1992) 46 Geier J, Schnuch A: No cross sensitization between MCI/MI, benzimidazolinone and octylisothiazolinone, Contact Dermatitis 34, 148 (1996) Environmental Dermatology 6 Suppl a Environmental Dermatology 5 Suppl

Contact Dermatitis, 34(1), 6 11 (1996) 29 Tinuin P 37 218 228 1991 30 Arisu K, Hayakawa R, Ogino K et al: Tinuvin P in a spandex tape as a cause of clothing dermatitis, Contact Dermatitis 26, 311 316

19 Environ Dermatol 9 Suppl : Nakamura A, Momma J, Sekiguchi H et al: A new protocol and criteria for quantitative determination of sensitization potencies of chemicals by guinea pig maximization test, Contact Dermatitis 31, (1994) 60 : Kaniwa M, Isama K, Nakamura A et al: Identification of causative chemicals of allergic contact dermatitis using a combination of patch testing and chemical analysis: application to cases from rubber gloves, Contact Dermatitis 31, (1994) 63 Kaniwa M, Momma J, Ikarashi Y et al: A method for identifying causative chemicals of allergic contact dermatitis using a combination of chemical analysis and patch testing in patients and animal groups: application to a case of boot dermatitis, Contact Dermatitis 27, (1992) 64 Kaniwa M, Isama K, Nakamura A et al: Identification of causative chemicals of allergic contact dermatitis using a combination of patch testing and chemical analysis: application to cases from rubber footwear, Contact Dermatitis, 30, (1994) Akimoto R, Mishima E, Washizaki K et al: A case of contact dermatitis due to a rubber belt. Environ Dermatol, 10, (2003) 68 Ikarashi Y, Ohno K, Momma J, et al, Nakamura A: Assessment ofcontact sensitivity of four thiourea rubber accelerators: comparison of two mouse lymph node assays with the guinea pig maximization test. Food Chem Toxicol 32(11), (1994) 69 Washimi Y, Suzuki K, Takeuchi M et al: A case of contact dermatitis due to a knee brace. Environ Dermatol, 9, (2002) 70 N isopropyl N phenyl p phenylenediamine Kaniwa M, Isama K, Nakamura A et al: Identification of causative chemicals of allergic contact dermatitis using a combination of patch testing in patients and chemical analysis. Application to cases from industrial rubber products, Contact Dermatitis 30, (1994) 73 Kaniwa M, Nishioka K, Miyako F et al: Analysis of allergenic chemicals in farmer s rubber boots causing allergic contact dermatitis and a trial for hypoallergenic rubber boots. Environmental Dermatology, 3, (1996) pharmsys.gr.jp/iyaku_anzen/pmdsi153.html 75 jp JIS T9010: ASTM D (1995), ASTM D (1999), ASTM D (2000)

by guinea pig maximization test, Contact Dermatitis 31, 72 85 (1994) 60 : 32 197 211 1986 61 34 325 334 1988 62 Kaniwa M, Isama K, Nakamura A et al: Identification of causative chemicals of allergic

20 OAS :

æ æ2 \ R esults of Open Patch Tests in Control Solutions Containing Ammonium Thioglycollate or Cysteine Group Using Cold Permanent Wave 3 \ Results of

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