2.7.4 2.7.4.1 2.7.4.1.1 11 ADH 1 ADH 1 4 7 129-A*-003 129-B*-001 129-E*-001P 129-G*-001 129-H*-002 129-H*-004 129-H*-005 132 242 4 129-B*-004 129-C*-005P 129-H*-003 129-H*-006 44 ADH ADH 129-C*-001P 16 129-C*-003P 12 ADH ADH 2.7.4-1 2.7.4-1 129-A*-003 24 36 12 129-B*-001 6 12 129-E*-001P 12 23 11 12 129-G*-001 32 47 129-H*-002 8 24 129-H*-004 20 40 129-H*-005 CYP3A4 30 60 129-B*-004 30mg/ 12 6 6 129-C*-005P 60mg/ 3 129-H*-003 10 129-H*-006 CYP3A4 16 ADH 129-C*-001P ADH 16 ADH 129-C*-003P 12 129-A*-003 129-E*-001P 129-B*-004 129-C*-005P 2.7.4 127
2 129-B*-006P 129-B*-007P 2 129-C*-004P 129-D*-001P 169 171 2.7.4-2 ADH 2.7.4-2 129-B*-006P 26 28 129-B*-007P 8 129-C*-004P 106 129-D*-001P Na 29 129-B*-006P 013873 2.7.2.1.2.1 2.7.4.1.1.1 MedDRA/J Ver.4.1 2.7.4 MedDRA/J Ver.7.0 (1) 129-E*-001P 129-G*-001 129-H*-002 129-H*-003 129-H*-004 129-H*-005 129-H*-006 129-A*-003 129-B*-001 129-B*-004 129-C*-005P (2) 129-C*-001P 2.7.4 128
129-C*-003P (3) 129-D*-001P 129-B*-006P 129-B*-007P 129-C*-004P 2.7.4.1.1.2 66 7 8 5 1 335 3 2.7.4.1.1.3 2.7.4-3 2.7.4 129
2.7.4-3 129-A*-003 12 129-B*-001 12 129-E*-001P 12 129-G*-001 12 129-H*-002 12 129-H*-004 12 129-H*-005 12 129-B*-004 12 129-C*-005P 12 129-H*-003 12 129-H*-006 12 ADH 129-C*-001P 12 ADH 129-C*-003P 12 129-B*-006P 12 129-B*-007P 12 129-C*-004P 12 129-D*-001P 12 FDP AST GOTALT GPTAl-P LDH-GTP BUNNa K Cl Ca LAP ip A/G CPK Mg ph 2.7.4 130
2.7.4.3 11 QT/QTc 2.7.4.1.2 2.7.4.1.2.1 2.7.4-4 2.7.4-4 1 1 3mg 15mg 30mg 60mg 90mg 100mg 200mg 1 6 6 184 14 8 18 6 242 7 0 6 6 6 0 0 0 18 10 0 0 26 0 0 0 0 26 6 12 216 20 8 18 6 286 1) 1 2) 129-A*-003 129-B*-001 129-E*-001P 129-G*-001 129-H*-002 129-H*-004 129-H*-005 129-A*-003 3 mg 15 mg 30 mg 60 mg 100 mg 200 mg 6 12 24 2 1 25 23 2 1 100 mg 1 129-B*-001 100 mg 6 129-E*-001P 30 mg 12 4 20 mg 1 1 12 11 129-G*-001 30 mg 1 16 1 16 2.7.4 131
15 16 16 30 mg 129-H*-002 30 mg 8 30 mg 1 60 mg 2 90 mg 3 129-H*-004 30 mg 1 30 mg 20 129-H*-005 30 mg 1 24 30 mg 1 2 6 129-B*-004 15 mg 1 2 30 mg 1 1 6 7 6 129-C*-005P 60 mg 6 1 1 7 3 129-H*-003 30 mg 10 1 1 10 129-H*-006 30 mg 16 1 1 10 2.7.4.1.2.2 2.7.4-5 2.7.4-5 1 1 30mg ADH 2 7 16 16 16 16 ADH 2 7 9 9 8 3 3 12 12 1) 1 2) 8 30mg 1 129-C*-001P ADH 30 mg 1 1 1 16 3 2 7 14 2 14 129-C*-003P ADH 30 mg 1 2.7.4 132
1 1 12 2 1 7 9 28 2 2.7.4.1.2.3 2.7.4-6 2.7.4-6 1 1 15mg 30mg 60mg 100mg 1 4 23 10 3 40 2 7 11 106 12 0 129 8 0 2 0 0 2 15 131 22 3 171 1) 1 2) 129-B*-006P 129-B*-006P 15 mg 30 mg 60 mg 100 mg 26 28 15 mg 30 mg 2 1 30 mg 60 mg 2 1 15 mg 4 30 mg 11 60 mg 10 100 mg 3 3 200 mg 6 129-B*-007P 30 mg 8 129-C*-004P 30 mg 1 7 106 1 4 2 1 3 6 4 2 5 2 6 1 7 88 8 2 129-D*-001P 15 mg 15 mg 1 30 mg 30 mg 1 60 mg 30 mg 2 7 29 15 mg 2 15 mg 4 15 mg 7 9 30 mg 7 6 60 mg 7 12 2.7.4.1.2.4 GCP 10 11 129-B*-005P 7 3 GCP 30 mg 60 mg 100 mg 7 8 30 mg 1 60 mg 2.7.4 133
6 100 mg 1 60 mg 100 mg 2 1 3 200 mg 6 60 mg 6 4 11 100 mg 1 1 1 60 mg 2 5 1 1 129-B*-005P 129-B*-006P GCP 2 30 mg 60 mg 129-D*-001P GCP 1 15 mg 1 2.7.4.1.3 2.7.4.1.3.1 176 24.8±3.9 ± 20 39 62.79±6.40kg 50.9 82.5kg 2.7.4-7 2.7.4-7 7 4 176 132 44 24.8 3.9 24.8 3.9 24.9 4.0 24.0 24.0 23.5 kg 20-39 20-39 20-36 62.79 6.40 62.52 6.26 63.59 6.82 62.80 62.90 62.40 50.9-82.5 50.9-82.2 53.7-82.5 2.7.4.1.3.2 ADH 16 ADH 12 ADH 10 62.5% 6 37.5% 63.9±8.1 48 78 65 8 50.0%65 8 50.0% ADH 8 50.0% 4 25.0% 2 12.5% 2.7.4-8 2.7.4 134
ADH 10 83.3% 2 16.7% 65.3±7.1 52 76 65 4 33.3%65 8 66.7% ADH 3 25.0 9 75.0 10 83.3% 4 33.3% 2 16.7% 1 8.3% 2.7.4-8 ADH ADH 2.7.4 135
2.7.4-8 ADH 129-C*-001P ADH 129-C*-003P 1 28 16 12 64.5 7.6 63.9 8.1 65.3 7.1 65.0 64.5 67.5 48-78 48-78 52-76 30 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 30 40 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 40 50 1 ( 3.6) 1 ( 6.3) 0 ( 0.0) 50 60 5 (17.9) 2 (12.5) 3 (25.0) 60 70 16 (57.1) 10 (62.5) 6 (50.0) 70 6 (21.4) 3 (18.8) 3 (25.0) 65 12 (42.9) 8 (50.0) 4 (33.3) 65 16 (57.1) 8 (50.0) 8 (66.7) 20 (71.4) 10 (62.5) 10 (83.3) 8 (28.6) 6 (37.5) 2 (16.7) ADH 16 (57.1) 16 (100) 0 ( 0.0) ADH 3 (10.7) 0 ( 0.0) 3 (25.0) 9 (32.1) 0 ( 0.0) 9 (75.0) 18 (64.3) 8 (50.0) 10 (83.3) 10 (35.7) 8 (50.0) 2 (16.7) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 8 (28.6) 4 (25.0) 4 (33.3) 4 (14.3) 2 (12.5) 2 ( 16.7) 1 ( 3.6) 0 ( 0.0) 1 ( 8.3) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 11 (39.3) 5 (31.3) 6 (50.0) 12 (42.9) 5 (31.3) 7 (58.3) 7 (25.0) 6 (37.5) 1 ( 8.3) 15 (53.6) 9 (56.3) 6 (50.0) 7 (25.0) 3 (18.8) 4 (33.3) 3 (10.7) 2 (12.5) 1 ( 8.3) 5 (17.9) 3 (18.8) 2 (16.7) 11 (39.3) 7 (43.8) 4 (33.3) 4 (14.3) 0 ( 0.0) 4 (33.3) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 7 (25.0) 3 (18.8) 4 (33.3) 4 (14.3) 2 (12.5) 2 (16.7) 0 ( 0.0) 0 ( 0.0) 0 ( 0.0) 1 2.7.4.1.3.3 169 169 100 59.2% 69 40.8% 57.4±11.0 22 79 65 123 72.8%65 46 27.2% 39 23.1% 52 30.8% 73 43.2% 5 3.0% 43 25.4% 2.7.4 136
26 15.4% 54 32.0% 60 35.5% 85 50.3% 2.7.4-9 2.7.4-9 1 169 57.4 11.0 58.0 22-79 30 4 ( 2.4) 30 40 7 ( 4.1) 40 50 26 (15.4) 50 60 57 (33.7) 60 70 54 (32.0) 70 21 (12.4) 65 123 (72.8) 65 46 (27.2) 100 (59.2) 69 (40.8) 39 (23.1) 52 (30.8) 73 (43.2) 2 5 ( 3.0) 43 (25.4) 26 (15.4) 54 (32.0) 60 (35.5) 85 (50.3) 33 (19.5) 124 (73.4) 9 ( 5.3) 93 (55.0) 34 (20.1) 22 (13.0) 34 (20.1) 45 (26.6) 71 (42.0) 10 ( 5.9) 23 (13.6) 7 ( 4.1) 13 ( 7.7) 1 2 2.7.4.2 2.7.4.2.1 2.7.4.1.1.1 2.7.4 137
2.7.4.2.1.1 (1) 2.7.4-10 286 51 17.8 80 33 14 42.4 27 27 9.4 22 7.7 13 4.5 1 0.3 14 4.9% 13 4.5 8 2.8 8 2.8% 8 24.2% 6 18.2% 3 9.1% 286 46 16.1 61 33 21 7.3% 18 6.3% 13 4.5% 1 0.3% 13 4.5% 10 3.5% 7 2.4% 7 2.4% 2.7.4-11 2.7.4-12 60 mg 90 mg 100 mg 200 mg 60 mg 2.7.4 138
2.7.4-10 a) / 286 242 44 33 24 9 80 53 27 27 18 9 N % N % N % N % N % N % 51 17.8 37 15.3 14 31.8 14 42.4 9 37.5 5 55.6 22 7.7 12 5.0 10 22.7 8 24.2 4 16.7 4 44.4 8 2.8 2 0.8 6 13.6 0 0.0 0 0.0 0 0.0 14 4.9 9 3.7 5 11.4 7 21.2 3 12.5 4 44.4 1 0.3 1 0.4 0 0.0 0 0.0 0 0.0 0 0.0 4 1.4 1 0.4 3 6.8 1 3.0 1 4.2 0 0.0 13 4.5 10 4.1 3 6.8 0 0.0 0 0.0 0 0.0 13 4.5 10 4.1 3 6.8 0 0.0 0 0.0 0 0.0 27 9.4 20 8.3 7 15.9 6 18.2 4 16.7 2 22.2 4 1.4 2 0.8 2 4.5 0 0.0 0 0.0 0 0.0 2 0.7 2 0.8 0 0.0 0 0.0 0 0.0 0 0.0 8 2.8 7 2.9 1 2.3 2 6.1 2 8.3 0 0.0 1 0.3 0 0.0 1 2.3 0 0.0 0 0.0 0 0.0 1 0.3 1 0.4 0 0.0 0 0.0 0 0.0 0 0.0 5 1.7 5 2.1 0 0.0 1 3.0 1 4.2 0 0.0 0 0.0 0 0.0 0 0.0 1 3.0 0 0.0 1 11.1 2 0.7 2 0.8 0 0.0 1 3.0 1 4.2 0 0.0 1 0.3 0 0.0 1 2.3 1 3.0 1 4.2 0 0.0 1 0.3 0 0.0 1 2.3 1 3.0 1 4.2 0 0.0 1 0.3 0 0.0 1 2.3 1 3.0 1 4.2 0 0.0 1 0.3 1 0.4 0 0.0 1 3.0 0 0.0 1 11.1 2 0.7 0 0.0 2 4.5 0 0.0 0 0.0 0 0.0 2 0.7 1 0.4 1 2.3 1 3.0 0 0.0 1 11.1 2 0.7 2 0.8 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 1 3.0 1 4.2 0 0.0 1 0.3 1 0.4 0 0.0 0 0.0 0 0.0 0 0.0 1 0.3 1 0.4 0 0.0 0 0.0 0 0.0 0 0.0 1 0.3 1 0.4 0 0.0 3 9.1 2 8.3 1 11.1 1 0.3 1 0.4 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 1 3.0 1 4.2 0 0.0 0 0.0 0 0.0 0 0.0 1 3.0 1 4.2 0 0.0 0 0.0 0 0.0 0 0.0 1 3.0 1 4.2 0 0.0 0 0.0 0 0.0 0 0.0 1 3.0 0 0.0 1 11.1 b) / 286 242 44 33 24 9 61 42 19 0 0 0 N % N % N % N % N % N % 46 16.1 33 13.6 13 29.5 0 0 0 18 6.3 8 3.3 10 22.7 0 0.0 0 0.0 0 0.0 7 2.4 1 0.4 6 13.6 0 0.0 0 0.0 0 0.0 10 3.5 5 2.1 5 11.4 0 0.0 0 0.0 0 0.0 1 0.3 1 0.4 0 0.0 0 0.0 0 0.0 0 0.0 4 1.4 1 0.4 3 6.8 0 0.0 0 0.0 0 0.0 13 4.5 10 4.1 3 6.8 0 0.0 0 0.0 0 0.0 13 4.5 10 4.1 3 6.8 0 0.0 0 0.0 0 0.0 21 7.3 19 7.9 2 4.5 0 0.0 0 0.0 0 0.0 4 1.4 2 0.8 2 4.5 0 0.0 0 0.0 0 0.0 2 0.7 2 0.8 0 0.0 0 0.0 0 0.0 0 0.0 7 2.4 7 2.9 0 0.0 0 0.0 0 0.0 0 0.0 1 0.3 1 0.4 0 0.0 0 0.0 0 0.0 0 0.0 5 1.7 5 2.1 0 0.0 0 0.0 0 0.0 0 0.0 2 0.7 2 0.8 0 0.0 0 0.0 0 0.0 0 0.0 2.7.4 139
/ 286 242 44 33 24 9 61 42 19 0 0 0 N % N % N % N % N % N % 46 16.1 33 13.6 13 29.5 0 0 0 1 0.3 1 0.4 0 0.0 0 0.0 0 0.0 0 0.0 2 0.7 2 0.8 0 0.0 0 0.0 0 0.0 0 0.0 1 0.3 1 0.4 0 0.0 0 0.0 0 0.0 0 0.0 1 0.3 1 0.4 0 0.0 0 0.0 0 0.0 0 0.0 2.7.4-11 / < < 15 mg 30 mg 60 mg 242 12 184 46 24 53 7 21 25 18 N % N % N % N % N % 37 15.3 5 41.7 13 7.1 19 41.3 9 37.5 12 5.0 1 8.3 5 2.7 6 13.0 4 16.7 2 0.8 0 0.0 1 0.5 1 2.2 0 0.0 9 3.7 0 0.0 4 2.2 5 10.9 3 12.5 1 0.4 1 8.3 0 0.0 0 0.0 0 0.0 1 0.4 0 0.0 1 0.5 0 0.0 1 4.2 10 4.1 0 0.0 0 0.0 10 21.7 0 0.0 10 4.1 0 0.0 0 0.0 10 21.7 0 0.0 20 8.3 4 33.3 9 4.9 7 15.2 4 16.7 2 0.8 1 8.3 1 0.5 0 0.0 0 0.0 2 0.8 0 0.0 2 1.1 0 0.0 0 0.0 7 2.9 3 25.0 0 0.0 4 8.7 2 8.3 1 0.4 0 0.0 1 0.5 0 0.0 0 0.0 5 2.1 0 0.0 4 2.2 1 2.2 1 4.2 2 0.8 0 0.0 0 0.0 2 4.3 1 4.2 0 0.0 0 0.0 0 0.0 0 0.0 1 4.2 0 0.0 0 0.0 0 0.0 0 0.0 1 4.2 0 0.0 0 0.0 0 0.0 0 0.0 1 4.2 1 0.4 0 0.0 0 0.0 1 2.2 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 1 0.4 0 0.0 1 0.5 0 0.0 0 0.0 2 0.8 0 0.0 1 0.5 1 2.2 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 1 4.2 1 0.4 1 8.3 0 0.0 0 0.0 0 0.0 1 0.4 1 8.3 0 0.0 0 0.0 0 0.0 1 0.4 0 0.0 1 0.5 0 0.0 2 8.3 1 0.4 0 0.0 1 0.5 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 1 4.2 0 0.0 0 0.0 0 0.0 0 0.0 1 4.2 0 0.0 0 0.0 0 0.0 0 0.0 1 4.2 3mg 15mg 60mg 90mg 100mg 200mg 2.7.4 140
2.7.4-12 / < < 15 mg 30 mg 60 mg 44 6 32 6 9 27 11 4 12 9 N % N % N % N % N % 14 31.8 5 83.3 3 9.4 6 100 5 55.6 10 22.7 5 83.3 1 3.1 4 66.7 4 44.4 6 13.6 4 66.7 0 0.0 2 33.3 0 0.0 5 11.4 3 50.0 0 0.0 2 33.3 4 44.4 3 6.8 1 16.7 1 3.1 1 16.7 0 0.0 3 6.8 0 0.0 0 0.0 3 50.0 0 0.0 3 6.8 0 0.0 0 0.0 3 50.0 0 0.0 7 15.9 1 16.7 3 9.4 3 50.0 2 22.2 2 4.5 0 0.0 2 6.3 0 0.0 0 0.0 1 2.3 0 0.0 1 3.1 0 0.0 0 0.0 1 2.3 0 0.0 0 0.0 1 16.7 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 1 11.1 1 2.3 1 16.7 0 0.0 0 0.0 0 0.0 1 2.3 1 16.7 0 0.0 0 0.0 0 0.0 1 2.3 1 16.7 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0 1 11.1 2 4.5 0 0.0 0 0.0 2 33.3 0 0.0 1 2.3 0 0.0 0 0.0 1 16.7 1 11.1 0 0.0 0 0.0 0 0.0 0 0.0 1 11.1 0 0.0 0 0.0 0 0.0 0 0.0 1 11.1 14 C- 013873 2.7.2.1.2.1 4 60 mg 3 5 1 2 2 (2) 2.7.4-13 ADH 16 11 68.8% 35 9 56.3% 5 31.3% 2 12.5% 1 6.3% 16 6 37.5% 15 5 31.3% 4 25.0% 1 6.3% ADH 12 9 75.0% 25 6 50.0% 2 16.7% 1 8.3% 2.7.4 141
12 5 41.7% 8 3 25.0% 1 8.3% 2.7.4-13 a) ADH ADH 129-C*-001P 129-C*-003P 28 16 12 60 35 25 N % N % N % 20 71.4 11 68.8 9 75.0 2 7.1 2 12.5 0 0.0 6 21.4 5 31.3 1 8.3 1 3.6 0 0.0 1 8.3 1 3.6 1 6.3 0 0.0 15 53.6 9 56.3 6 50.0 3 10.7 1 6.3 2 16.7 1 3.6 0 0.0 1 8.3 1 3.6 1 6.3 0 0.0 1 3.6 0 0.0 1 8.3 b) ADH ADH 129-C*-003P 129-C*-001P 28 16 12 23 15 8 N % N % N % 11 39.3 6 37.5 5 41.7 6 21.4 5 31.3 1 8.3 1 3.6 0 0.0 1 8.3 7 25.0 4 25.0 3 25.0 1 3.6 1 6.3 0 0.0 1 3.6 1 6.3 0 0.0 1 3.6 0 0.0 1 8.3 2.7.4-14 ADH 5 31.3% 2 12.5% ADH 5 31.3% 2 12.5% ADH γ- 2.7.4 142
2 16.7% ADH 1 ADH 1 3 2.7.4-14 a) ADH ADH 129-C*-003P 129-C*-001P 28 16 12 60 35 25 N % N % N % 20 71.4 11 68.8 9 75.0 2 7.1 2 12.5 0 0.0 1 3.6 1 6.3 0 0.0 1 3.6 1 6.3 0 0.0 6 21.4 5 31.3 1 8.3 1 3.6 1 6.3 0 0.0 6 21.4 5 31.3 1 8.3 1 3.6 0 0.0 1 8.3 1 3.6 0 0.0 1 8.3 1 3.6 1 6.3 0 0.0 1 3.6 1 6.3 0 0.0 15 53.6 9 56.3 6 50.0 3 10.7 1 6.3 2 16.7 3 10.7 1 6.3 2 16.7 2 7.1 1 6.3 1 8.3 1 3.6 1 6.3 0 0.0 1 3.6 1 6.3 0 0.0 1 3.6 0 0.0 1 8.3 1 3.6 1 6.3 0 0.0 2 7.1 0 0.0 2 16.7 1 3.6 1 6.3 0 0.0 2 7.1 2 12.5 0 0.0 1 3.6 1 6.3 0 0.0 1 3.6 1 6.3 0 0.0 1 3.6 1 6.3 0 0.0 2 7.1 0 0.0 2 16.7 1 3.6 1 6.3 0 0.0 1 3.6 0 0.0 1 8.3 2 7.1 2 12.5 0 0.0 2 7.1 2 12.5 0 0.0 1 3.6 0 0.0 1 8.3 1 3.6 0 0.0 1 8.3 2 7.1 1 6.3 1 8.3 2 7.1 2 12.5 0 0.0 1 3.6 0 0.0 1 8.3 1 3.6 1 6.3 0 0.0 1 3.6 0 0.0 1 8.3 1 3.6 1 6.3 0 0.0 1 3.6 0 0.0 1 8.3 1 3.6 0 0.0 1 8.3 2 7.1 1 6.3 1 8.3 1 3.6 1 6.3 0 0.0 3 10.7 1 6.3 2 16.7 2.7.4 143
ADH ADH 129-C*-003P 129-C*-001P 28 16 12 60 35 25 N % N % N % 20 71.4 11 68.8 9 75.0 1 3.6 0 0.0 1 8.3 2 7.1 1 6.3 1 8.3 1 3.6 0 0.0 1 8.3 1 3.6 0 0.0 1 8.3 1 3.6 1 6.3 0 0.0 1 3.6 1 6.3 0 0.0 1 3.6 0 0.0 1 8.3 1 3.6 0 0.0 1 8.3 b) ADH ADH 129-C*-003P 129-C*-001P 28 16 12 23 15 8 N % N % N % 11 39.3 6 37.5 5 41.7 6 21.4 5 31.3 1 8.3 1 3.6 1 6.3 0 0.0 6 21.4 5 31.3 1 8.3 1 3.6 0 0.0 1 8.3 1 3.6 0 0.0 1 8.3 7 25.0 4 25.0 3 25.0 2 7.1 1 6.3 1 8.3 2 7.1 1 6.3 1 8.3 1 3.6 1 6.3 0 0.0 1 3.6 0 0.0 1 8.3 1 3.6 1 6.3 0 0.0 2 7.1 2 12.5 0 0.0 1 3.6 1 6.3 0 0.0 1 3.6 0 0.0 1 8.3 1 3.6 0 0.0 1 8.3 1 3.6 1 6.3 0 0.0 1 3.6 1 6.3 0 0.0 1 3.6 1 6.3 0 0.0 1 3.6 1 6.3 0 0.0 1 3.6 0 0.0 1 8.3 1 3.6 0 0.0 1 8.3 (3) 2.7.4-15 171 115 67.3% 329 90 52.6% 26 15.2% 23 13.5% 5% 2.7.4 144
171 82 48.0% 148 50 29.2% 24 14.0% 19 11.1% 5% 2.7.4-15 a) 129-B*-006P 129-B*-007P 129-C*-004P 129-D*-001P 171 28 8 106 29 329 66 8 203 52 N % N % N % N % N % 115 67.3 16 57.1 6 75.0 74 69.8 19 65.5 4 2.3 0 0.0 0 0.0 3 2.8 1 3.4 1 0.6 0 0.0 0 0.0 1 0.9 0 0.0 23 13.5 1 3.6 1 12.5 15 14.2 6 20.7 26 15.2 3 10.7 5 62.5 15 14.2 3 10.3 90 52.6 15 53.6 2 25.0 59 55.7 14 48.3 6 3.5 0 0.0 0 0.0 3 2.8 3 10.3 1 0.6 0 0.0 0 0.0 1 0.9 0 0.0 2 1.2 1 3.6 0 0.0 1 0.9 0 0.0 2 1.2 0 0.0 0 0.0 2 1.9 0 0.0 3 1.8 1 3.6 0 0.0 2 1.9 0 0.0 2 1.2 0 0.0 0 0.0 2 1.9 0 0.0 1 0.6 0 0.0 0 0.0 1 0.9 0 0.0 b) 129-B*-006P 129-B*-007P 129-C*-004P 129-D*-001P 171 28 8 106 29 148 29 6 96 17 N % N % N % N % N % 82 48.0 11 39.3 6 75.0 53 50.0 12 41.4 4 2.3 0 0.0 0 0.0 3 2.8 1 3.4 19 11.1 1 3.6 1 12.5 13 12.3 4 13.8 24 14.0 3 10.7 5 62.5 14 13.2 2 6.9 50 29.2 8 28.6 0 0.0 35 33.0 7 24.1 3 1.8 0 0.0 0 0.0 2 1.9 1 3.4 2 1.2 1 3.6 0 0.0 1 0.9 0 0.0 1 0.6 0 0.0 0 0.0 1 0.9 0 0.0 1 0.6 0 0.0 0 0.0 1 0.9 0 0.0 2.7.4-54 5% 2.7.4-16 16 9.4% 12 7.0% 11 6.4% 10 5.8% 9 5.3% 2.7.4 145
14 8.2% 12 7.0% 11 6.4% 10 5.8% 16 14 11 10 1 3 2 6 2.7.4-16 5% a) 129-B*-006P 129-B*-007P 129-C*-004P 129-D*-001P 171 28 8 106 29 329 66 8 203 52 N % N % N % N % N % 115 67.3 16 57.1 6 75.0 74 69.8 19 65.5 16 9.4 0 0.0 0 0.0 12 11.3 4 13.8 11 6.4 0 0.0 0 0.0 10 9.4 1 3.4 12 7.0 3 10.7 5 62.5 2 1.9 2 6.9 9 5.3 2 7.1 0 0.0 7 6.6 0 0.0 9 5.3 0 0.0 0 0.0 6 5.7 3 10.3 9 5.3 0 0.0 0 0.0 8 7.5 1 3.4 16 9.4 5 17.9 0 0.0 7 6.6 4 13.8 10 5.8 1 3.6 0 0.0 3 2.8 6 20.7 10 5.8 4 14.3 0 0.0 6 5.7 0 0.0 12 7.0 4 14.3 0 0.0 8 7.5 0 0.0 10 5.8 4 14.3 0 0.0 6 5.7 0 0.0 b) 129-B*-006P 129-B*-007P 129-C*-004P 129-D*-001P 171 28 8 106 29 148 29 6 96 17 N % N % N % N % N % 82 48.0 11 39.3 6 75.0 53 50.0 12 41.4 14 8.2 0 0.0 0 0.0 11 10.4 3 10.3 10 5.8 0 0.0 0 0.0 10 9.4 0 0.0 12 7.0 3 10.7 5 62.5 2 1.9 2 6.9 11 6.4 4 14.3 0 0.0 4 3.8 3 10.3 2.7.4 146