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Considering past human tolls in natural disasters, failure of low strength masonry houses in earthquakes has been the primary cause of live losses. Majority of population Nepal live in low strength masonry houses. So, I was interested to know whether there are possibilities to make these houses earthquake resistant. I was encouraged when Japanese government provided me scholarship and Professor Charles Scawthorn accepted me in earthquake disaster prevention systems lab, Kyoto University. Low strength masonry houses are constructed by locally trained masons using locally available materials such as stones, bricks, woods etc. Various materials such as fiber reinforced polymer, poly-propylene band, steel beams and columns have been increasingly used for strengthening of structures nowadays. These materials are not available in the remote areas, should be transported from long distances and require skilled manpower. If these materials were used, the cost of strengthening would be three-four times more than the cost of existing houses. Poor people in remote areas are living in these kinds of houses and they can not afford expensive materials. Thus I am looking for the strengthening measures which use local materials and locally trained persons so that people could afford. Focusing the Himalayan region, the specific research interests are to simulate seismic input, to evaluate performance of houses at simulated seismic input, and to optimize the strengthening measures. Like Japan, Himalayan region has also experienced many damaging earthquakes in its history. Notes scribbled on some Nepalese religious tracts indicate that a big quake hit Kathmandu in June 1255 AD. The quake killed one-third of the population of the country. Since then severe earthquakes occurred in 1405, 1408, 1681, 1810, 1833, 1866 and 1934 AD. Historical records show that at least as far back as the early 18th century, damaging earthquakes have occurred in the Himalayan region every few decades. But since 1950, the Himalaya has remained quiet. Calculated slip rate of whole Himalayan-arc from available earthquake data is only one third of observed from GIS maps. It shows that either the earthquakes records are missing or severe earthquakes may be overdue and the worst may be yet to come. Thus, I estimated seismic hazard considering intra-plate slip, historical earthquakes and faults. Evaluation of performance of masonry houses when estimated hazard is given is the next part of the study. A finite element numerical model capable of modeling discontinuities at joints between the masonry units is formulated considering units as linear elastic solid elements and interfaces between the units as non linear joint elements governed by friction. I have taken case study of dry stone masonry houses called Bhatar in Pakistan and Hatil in Turkey. Similar, houses are found in western Nepal also. Non linear dynamic analyses of masonry houses are done varying numbers of rooms, storeys, materials types and patterns, and their effectiveness are investigated. As an alternate idea for strengthening, steel mesh reinforcements are applied in different patterns, so that I could conclude optimized area to be covered, size and spacing of reinforcements.