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FDG-PET 2005 PET

1 2 3 FDG-PET 3 FDG-PET 4 FDG 5 PET 5 6 10 FDG-PET 10 12 FDG 14 PET 14 17 18 19

Positron emission tomography PET PET 11 C 15 O 18 F PET PET 511keV 180 2 PET PET PET 2-deoxy-2-[F-18] fluoro-d-glucosefdg FDG PET PET PET PET PET PET PET 18 F 99m Tc 7 FDG-PET 1

FDG-PET PET PET 10 1. FDG-PET 2. FDG-PET 3. FDG 4. PET 5. 6. 7. FDG-PET 8. 9. FDG 10. PET FDG FDG FDG-PET FDG-PET 16 8 16 8 1 0801001 2

1. 24 7 FDG FDG FDG FDG 2. 1. 2. 1. FDG-PET 1.1 FDG-PET ALARAas low as reasonably achievable 1 1.2 FDG-PET 3

1.3 (1 FDG-PET (2 (3 FDG-PET (4 (5 FDG-PET FDG FDG FDG PET (6 FDG-PET (7 (8) FDG-PET 2. FDG-PET PETFDG-PET 1FDG-PET 2FDG-PET 3FDG 4FDG 5PET 6 7 8 FDG FDG-PET (9) 4

3. FDG FDG FDG PET (1) (2) (3) (4) (5) (6) (7) 2--2--D- ( 18 F) (8) 4. PET PET 1 FDG-PET 2 FDG-PET 3 4 PET FDG PET 5

(1) PET (2) (3) (4) (5) (6) (7) (8) PET-CT CT (9) (10) 2D 3D (11) (12) (13) (14) (15) 5. FDG-PET 1 2FDG 3FDG 4FDG-PET 5 6FDG-PET 5.1 FDG-PET FDG ICRP Publication 80 1 185 MBq(5mCi) 3.5mSv 68Ge 68 Ga 0.25mSv PET-CT X CT 1.43.5mSv CT 10mSv 6

1 FDG 15 10 5 1 (mgy/mbq) 0.011 0.014 0.022 0.032 0.061 (mgy/mbq) 0.160 0.210 0.280 0.320 0.590 (msv/mbq) 0.019 0.025 0.036 0.050 0.095 FDG-PET 2004 FDG PET MIRD 5.2 5.2.1 FDG PET PET FDG PET PET 30 18 30 27 PET 5mSv6mSv 7

FDG 5mSv PET 5.2.2 PET PET FDG FDG PET FDG PET FDG 5.2.3 1mSv 2mSv 5.2.4 FDG FDG (1) FDG (2) (3) (4) (5) FDG FDG 8

FDG 5.2.5 FDG FDG FDG PET 1 2PET 3FDG FDG FDG 5.2.6 PET PET 2 5.2.7 PET 400500 MBq 4050Sv/hr80100Sv/hr 510Sv/hr 9

. 1 FDG 2 FDG 2 10 3 FDG-PET 4 FDG-PET ICRP Publication 60(1991)10 7. FDG-PET 7.1 FDG-PET 30 8 2 PET 1 FDG 2 FDG PET PET 3FDG FDG-PET 3 3 10

4PET 5(1) (4) FDG 7.2 (1) 1 1mSv (2) 3 1.3mSv (3) 3 250Sv (4) 3 1.3mSv 7.3 PET PET PET 11

1mSv 50 50mSv 5 100mSv 1 20mSv PET PET PET PET 8. 8.1 19 1 13 30 11 1 5 30 14 2 1 16 3 25 18 F PET 7 1 18 F 5TBq 2 PET 3 12

FDG-PET 5 4 5 1 1mSv 8.2 30 11 1 2 30 26 1 FDG-PET 8.3 30 11 1 3 30 26 1 30 26 1 FDG 13

9. FDG FDG 9.1 FDG FDG 18 18 56 5 16 10 30 10 9.2 FDG FDG FDG FDG 10. PET PET PET 10.1 28 1 (1) 24 7 (2) 24 8 (3) 24 12 14

28 1 1 2 3 4 5 10.2 10.1 1 28 1 28 1 4 (1) PET PET (2) 28 1 5 PET 1 28 1 5 29 2 (1) (2) PET (3) 3 (4) PET 15

FDG FDG 16

ICRP Publication 80 1998: 49. National Council on Radiation Protection and Measurements. Limitations of exposure to ionizing radiation. National Council on Radiation Protection and Measurements ; NCRP Report No.116; 1993 Medical and Dental Guidance Notes: A good practice guide on all aspects of ionising radiation protection in the clinical environment. IPEM, 2002 17

10 t A A 0 e t 1 Adt t A 0 t 0 0 e t E T A 0 t 1 0 t 1 A t0 0 0 e t dt 1 2 f L 0 2 1 e t 1 3 A 0 1et 1 1 2 f L 0 4 E T Sv A t t MBq 0.693/T Svm MBq -1 h -1 Th=1.83h Lm 1

PET FDG-PET 185MBq/ A 3 50 A 3 A 0 e t A 3 185 e 0.693 1.83 50 60 135MBq 40min/ m E T 1.83 135 1 0.693 e 0.693 40 1.83 60 1 0.140 1 2 1 11.1Sv/1 50 11.1Sv/1 /5/50/ 1000Sv/mSv19.5mSv/ 50 11.1Sv/1 /5/50/ 1000Sv/mSv22.2mSv/ T 1mSv 50mSv 250Sv 100mSv 20Sv 1.3GB 19.5mSv 20mSv PET 2

1.38GBq 22.2mSv 20mSv PET A/20SvmSv msva. 0.98 0.24 0.11. 1.11 0.28 0.12. 1.39 0.35 0.15. 1.81 0.45 0.20 20mSv 20Sv 1 20Sv 1 20mSv 20mSv 65 1 11.1Sv/1 1/5/13/ 1000Sv/mSv0.72mSv/ 130 3

11.1Sv/1 2/5/13/ 1000Sv/mSv1.44mSv/ PET 1.3mSv 185MBq 0.72mSv 1.3mSv/ 370MBq 1.45mSv 1.3mSv/ PET B/1.3SvmSv msvb. 0.56 0.14 0.06. 1.11 0.28 0.12. 1.67 0.42 0.19. 2.22 0.56 0.25. 2.78 0.69 0.31. 3.33 0.83 0.37. 4.45 1.11 0.49. 5.55 1.39 0.62. 7.22 1.8 0.8.3mSv 1.3mSv 4

PET FDG-PET 185MBq/ A 3 50 A 3 185 e 0.693 1.83 50 60 135MBq 20min/ m E T 135 1.83 1e 0.693 0.693 1.83 20 60 0.140 1 2 1 1 6.09Sv/1 13 50 6.09Sv/1 13/5/50/ 1000Sv/mSv19.8mSv/ 14 50 6.09Sv/1 14/5/50/ 1000Sv/mSv21.4mSv/ PET 1mSv 50mSv 250 Sv 100mSv 20 Sv 3 13 1 2.4GBq 19.8mSv 20mSv PET 3 14 2.6GBq 1m 5

21.4mSv 20mSv PET C/20SvmSv msvc. 0.77 0.19 0.09. 0.99 0.25 0.11. 1.07 0.27 0.12. 1.15 0.29 0.13. 1.53 0.38 0.17. 1.91 0.48 0.21. 2.29 0.57 0.25 20mSv 20Sv 20Sv 20mSv 20mSv (1) (2) 13 195 6.09Sv/1 3/5/13/ 1000Sv/mSv1.19mSv/ 13 260 6

6.09Sv/1 2/5/13/ 1000Sv/mSv1.58mSv/ T 1.3mSv 555MBq 1.19mSv 1.3mSv/ 740MBq 1.58mSv 1.3Sv/ PET D/1.3SvmSv msvd. 0.92 0.23 0.1. 1.22 0.31 0.14. 1.52 0.38 0.17. 1.83 0.46 0.2. 2.43 0.61 0.27. 3.05 0.76 0.34. 3.95 0.99 0.44. 6.09 1.52 0.68. 9.14 2.29 1.02.3mSv 1 1.3mSv 7

FDG-PET 185MBq/ A 185MBq 10 0.693 1.83 A 2 185 e 10 60 174MBq 40min/ m E T 1.83 174 1 0.693 e 0.693 40 1.83 60 1 0.140 1 2 1 14.4Sv 14.4Sv/1 50 14.4Sv/1 /5// 1000Sv/mSv18mSv/ 50 14.4Sv/1 /5// 1000Sv/mSv21.6mSv/ 1mSv 50mSv 250Sv 100mSv 20Sv 925MBq 20mSv 8

1.11GBq 21.6mSv 20mSv E/20SvmSv msve. 1.08 0.27 0.12. 1.44 0.36 0.16. 1.80 0.45 0.20. 2.34 0.59 0.26. 2.52 0.63 0.28. 2.70 0.68 0.3. 3.6 0.9 0.4. 5.4 1.35 0.6 21.6mSv 20mSv 20Sv 1 20Sv 20mSv 20mSv (1) (2) 13 65 14.4Sv/1 /5/13/ 1000Sv/mSv0.94mSv/ 13 130 9

14.4Sv/1 2/5/13/ 1000Sv/mSv1.88mSv/ T 1.3mSv 185MBq 0.94mSv 1.3mSv/ 374MBq 1.88mSv 1.3Sv/ PET F/1.3SvmSv msvf. 0.72 0.18 0.08. 1.45 0.36 0.16. 2.16 0.54 0.24. 2.88 0.72 0.32. 3.6 0.9 0.4. 4.32 1.08 0.48. 5.76 1.44 0.64. 7.2 1.8 0.8. 10.8 2.7 1.2. 14.4 3.6 1.6. 21.6 5.4 2.4.3mSv 1 1.3mSv 10

PET 1. FDG-PET10185MBq 27.8mSv D5.4m 27.85.4 2 =0.95mSv 0.9520=0.0481 2. 27.22mSv A3.15m 7.223.15 2 =0.73mSv 0.731.3=0.5621 3. 20 7.2223.15 2 =1.46mSv 1.461.3=1.123 1 1.3mSv 18 F 3mm 0.690 1.1230.69=0.775 3mm 4. 1FDG 20mSv msv/20msv 1 1 2 20mSv (msv)/20msv 1 1 11

20mSv 1m 1 / 1 /m 2 1 1 9 m2.5m 2 1m 0.975 3mm 0.69 0.9759/70.69/2.5 2 =0.138 12

CT-PET 13

PET PET 18

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1. 2. 40 2-1 20 3. 4. PET 1. PET