短 報 小動物臨床関連部門 要 約 Helicobacter Helicobacter pylorih. pylori H. pylori Helicobacter heilmannii H. heilmannii Mucosa associated lymphoid tissuemlt H. pylori H. heilmannii, Helicobacter felish. heilmannii H. pylori ridgeford H. heilmannii 症例.kg /. X mm FX E-mail : makototsuji@gmail.com 523 70
m arm H. pylori m lymphoepithelial lesionlel. CD CD PCR DN 治療と経過及び再検査 Meiji Seika mg/kg ID mg/kg ID.mg/kg SID Pure- 70 524
HE arm LEL arm Link Genomic DN Mini Kit DN DN KOD FX Neo S RN PCR bp PCR bp H. heilmannii H. heilmannii 考察 MLT CD arm CD arm Diffuse large -cell lymphoma DLCL MLT MLT H. pylori H. pylori 525 70
HE arm arm LEL DLCL MLT LEL MLT MLT MLT H. heilmannii H. heilmannii H. heilmannii MLT, H. heilmannii MLT 70 526
引用文献 Kamada T, Haruma K, Ito M, Inoue K, Manabe N, Matsumoto H, Kusunoki H, Hata J, Yoshihara M, Sumii K, kiyama T, Tanaka S, Shiotani, Graham DY : Time trends in Helicobacter pylori infection and atrophic gastritis over years in Japan, Helicobacter,,, () Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M, Taniyama K, Sasaki N, Schlemper RJ : Helicobacter pylori infection and the development of gastric cancer, N Engl J Med,,, () Van den ulck K, Decostere, aele M, Driessen, Debongnie JC, urette, Stolte M, Ducatelle R, Haesebrouck F : Identification of non-helicobacter pylori spiral organisms in gastric samples from humans, dogs, and cats, J Clin Microbiol,, () Wotherspoon C, Ortiz-Hidalgo C, Falzon MR, Isaacson PG : Helicobacter pylori-associated gastritis and primary -cell gastric lymphoma, Lancet,, () Morgner, Lehn N, ndersen LP, Thiede C, ennedsen M, Trebesius K, Neubauer, Neubauer, Stolte M, ayerdörffer E : Helicobacter heilmannii-associated primary gastric low-grade MLT lymphoma: complete remission after curing the infection, Gastroenterology,, () Nakamura S, Sugiyama T, Matsumoto T, Iijima K, Ono S, Tajika M, Tari, Kitadai Y, Matsumoto H, Nagaya T, Kamoshida T, Watanabe N, Chiba T, Origasa H, saka M : Long-term clinical outcome of gastric MLT lymphoma after eradication of Helicobacter pylori: a multicentre cohort follow-up study of patients in Japan, Gut,, () Jalava K, On SL, Vandamme P, Happonen I, Sukura, Hänninen ML : Isolation and identification of Helicobacter spp. from canine and feline gastric mucosa, ppl Environ Microbiol,, () Neiger R, Dieterich C, urnens, Waldvogel, Corthésy-Theulaz I, Halter F, Lauterburg, Schmassmann : Detection and prevalence of Helicobacter infection in pet cats, J Clin Microbiol,, () Handt LK, Fox JG, Dewhirst FE, Fraser GJ, Paster J, Yan LL, Rozmiarek H, Rufo R, Stalis IH : Helico- bacter pylori isolated from the domestic cat: public health implications, Infect Immun,, () ridgeford EC, Marini RP, Feng Y, Parry NM, Rickman, Fox JG : Gastric Helicobacter species as a cause of feline gastric lymphoma: a viable hypothesis, Vet Immunol Immunopathol,, () Trebesius K, dler K, Vieth M, Stolte M, Haas R : Specific detection and prevalence of Helicobacter heilmannii-like organisms in the human gastric mucosa by fluorescent in situ hybridization and partial S ribosomal DN sequencing, J Clin Microbiol,, () ORourke JL, Solnick JV, Neilan, Seidel K, Hayter R, Hansen LM, Lee : Description of Candidatus Helicobacter heilmannii based on DN sequence analysis of S rrn and urease genes, Int J Syst Evol Microbiol,, () Wotherspoon, Chot, Gascoyne RD, Müller-Hermelink HK : Lymphoma of the stomac, Pathology and Genetics of Tumours of the Digestive System, WHO/ IRC Classification of Tumours, rd,,, IRC Press, Lyon () Moore PF, Rodriguez-ertos, Kass PH : Feline gastrointestinal lymphoma: mucosal architecture, immunophenotype, and molecular clonality, Vet Pathol,, () Mochizuki H, Nakamura K, Sato H, Goto-Koshino Y, Sato M, Takahashi M, Fujino Y, Ohno K, Uchida K, Nakayama H, Tsujimoto H : Multiplex PCR and Genescan analysis to detect immunoglobulin heavy chain gene rearrangement in feline -cell neoplasms, Vet Immunol Immunopathol,, () Stephen CThe -minute veterinary consult clinical companion: canine and feline infection diseases and parasitology Fischbach W, Goebeler ME, Ruskone-Fourmestraux, Wündisch T, Neubauer, Raderer M, Savio : Most patients with minimal histological residuals of gastric MLT lymphoma after successful eradication of Helicobacter pylori can be managed safely by a watch and wait strategy: experience from a large international series, Gut,, () Robert CDHelicobacter Handbook of small animal gastroenterology 527 70
Case Report of Complete Remission in Feline Gastric Small -cell Lymphoma fter Helicobacter Eradication Therapy Makoto TSUJI ), Koki UEMOTO ), Tetsuya KWSKI ), Yasuo ISHIZUK ) and Takeshi IZW ) ) Ishizuka nimal Hospital, 11213 Fujiicho, Kishiwada, 5960046, Japan ) Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 158 Rinku-oraikita, Izumisano, 5988531, Japan SUMMRY -year-old spayed female byssinian cat had intermittent vomitting. Using gastrointestinal endoscopy, a massive lesion was found in the gastric mucosa. diagnosis of Helicobacter infection was made, and gastric small -cell lymphoma was diagnosed using cytopathology and histopathology of endoscopic samples. However, the samples were negative for lymphoid clonality. The cat was treated with Helicobacter eradication therapy for days without any anticancer drugs. s a result, the symptoms resolved, and the lymphoma achieved complete remission. The recurrence of lymphoma in the gastric mucosa was not observed after one year of therapy, although a mild Helicobacter infection presisted. Key words : cat, gastric lymphoma, Helicobacter eradication therapy. Correspondence to : Makoto TSUJI (Ishizuka nimal Hospital) 11213 Fujiicho, Kishiwada, 5960046, Japan TEL 0724304666FX 0724305667E-mail : makototsuji0530@gmail.com J. Jpn. Vet. Med. ssoc.,, () 70 528