Similar documents
Fig. 1 Clinical findings and extent of inflammation area in female urethrocystitis Fig. 2 Classification and distribution of female patients with blad

Key words : 7432-S, Oral cephem, Urinary tract infection Fig. 1. Chemical structure of 7432-S.

VOL. 34 S-2 CHEMOTH8RAPY 913

VOL.42 S-1

Studies of Foot Form for Footwear Design (Part 9) : Characteristics of the Foot Form of Young and Elder Women Based on their Sizes of Ball Joint Girth

CHEMOTHERAPY JUN Citrobacter freundii 27, Enterobacter aerogenes 26, Enterobacter cloacae 27, Proteus rettgeri 7, Proteus inconstans 20, Proteus

THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec LVFX 100 mg 3 / mg 2 / LVFX PK PD mg mg 1 1 AUC/MIC


Visual Evaluation of Polka-dot Patterns Yoojin LEE and Nobuko NARUSE * Granduate School of Bunka Women's University, and * Faculty of Fashion Science,

CHEMOTHERAPY JUNE 1993 Table 1. Background of patients in pharmacokinetic study

０８０１２９７，繊維学会ファイバ１１月号／報文－０１－青山

Fig. 1 Chemical structure of DL-8280

VOL.35 S-2 CHEMOTHERAPY Table 1 Sex and age distribution Table 2 Applications of treatment with carumonam Table 3 Concentration of carumonam in human

Fig. 1 Chemical structure of norfioxacin (AM-715)

CHEMOTHERAPY

A Nutritional Study of Anemia in Pregnancy Hematologic Characteristics in Pregnancy (Part 1) Keizo Shiraki, Fumiko Hisaoka Department of Nutrition, Sc


Fig. 1 Chemical structure of KW-1070

CHEMOTHERAPY Table 1 Urinary excretion of mezlocillin Fig. 4 Urinary excretion of mezlocillin Fig. 3 Blood levels of mezlocillin


Table1MIC of BAY o 9867 against standard strains


Fig. 1 Photography of exercise test by Arm Crank Ergometer. Fig. 2 Photography of exercise test by chair with caster. Arm Crank Ergometer Wheelchair T

Study on Application of the cos a Method to Neutron Stress Measurement Toshihiko SASAKI*3 and Yukio HIROSE Department of Materials Science and Enginee

VOL.39 S-3

8 The Bulletin of Meiji University of Integrative Medicine API II 61 ASO X 11 7 X-4 6 X m 5 X-2 4 X 3 9 X 11 7 API 0.84 ASO X 1 1 MR-angio

CHEMOTHERAPY Table 1 Clinical effect of Sultamicillin

epidermidis, Enterococcus faecalis, Enterococcus Klebsiella pneumoniae, Proteus mirabilis, indolepositive Proteus spp., Enterobacter spp., Serratia

CHEMOTHERAPY FEB Table 1. Activity of cefpirome and others against clinical isolates

特殊病態下感染症における抗菌薬治験の手引き作成委員会報告書（案）

Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates


CHEMOTHERAPY FEB Table 1 Background of volunteers

CHEMOTHERAPY APR Fig. 1 Chemical structure of cefotetan (CTT, YM09330)

CHEMOTHERAPY Fig. 1 Chemical structure of CXM-AX



2 The Bulletin of Meiji University of Integrative Medicine 3, Yamashita 10 11

Table 1. Antibacterial spectrum SBT ABPC ABPC CPZ : sulbactamiampicillin : ampicillin : cefoperazone

Fig. 1 Trends of TB incidence rates for all forms and smear-positive pulmonary TB in Kawasaki City and Japan. Incidence=newly notified cases of all fo

社会学部紀要　１１８号☆／６．藤原


Continuous Cooling Transformation Diagrams for Welding of Mn-Si Type 2H Steels. Harujiro Sekiguchi and Michio Inagaki Synopsis: The authors performed

988 CHEMOTHERAPY NOV. 1971

Title 泌尿器科領域に於ける17-Ketosteroidの研究 17-Ketosteroidの臨床的研究 第 III 篇 : 尿 Author(s) 卜部, 敏入 Citation 泌尿器科紀要 (1958), 4(1): 3-31 Issue Date URL

Key words: bacterial meningitis, Haemophilus influenzae type b, Streptococcus pneumoniae, rapid diagnosis, childhood

〈企業特集：検査機器・試薬・技術の新たな展開〉新規マイコプラズマ抗原検査キット—プロラスト®Myco

CHEMOTHERAPY MAY. 1988


Journal of Geography 116 (6) Configuration of Rapid Digital Mapping System Using Tablet PC and its Application to Obtaining Ground Truth

56 pp , 2005 * ******* *** ** CA CAMA


320 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /., No.1, -,* -,/ (,**1) 8 * ** *** * ** *** E#ect of Superheated Steam Treatment on the Preservation an

Web Stamps 96 KJ Stamps Web Vol 8, No 1, 2004

九州大学学術情報リポジトリ Kyushu University Institutional Repository 看護師の勤務体制による睡眠実態についての調査 岩下, 智香九州大学医学部保健学科看護学専攻 出版情報 : 九州大学医学部保健学

untitled

MV X 5 6 Common Terminology Criteria for Adverse Events Grade 1 Grade Gy 16 QOL QOL 5 6 7, 8 9, VOL.3 NO

(43) Vol.33, No.6(1977) T-239 MUTUAL DIFFUSION AND CHANGE OF THE FINE STRUCTURE OF WET SPUN ANTI-PILLING ACRYLIC FIBER DURING COAGULATION, DRAWING AND

_念3）医療2009_夏.indd

Kyoto University * Filipino Students in Japan and International Relations in the 1930s: An Aspect of Soft Power Policies in Imperial Japan


渡辺(2309)_渡辺(2309)

36:378 第 38 回日本脳卒中学会講演シンポジウム 原著 36: , 要旨 TIA 2 t-pa Key words: stroke registry, stroke subtype, onset-visi

Clostridium difficile ciprofloxacin, ofloxacin, norfloxacin Bifidobacterium Lactobacillus Lactobacillus Bacteroides fragilis B. fragilis C. difficile


(1 ) (2 ) Table 1. Details of each bar group sheared simultaneously (major shearing unit). 208

Transcription:

Table 1.Distribution and number of cases with acute upper respiratory tract infections classified according to antimicrobial agents administered

Table 2. Distribution of cases which were enrolled to set up new diagnostic criteria of acute upper respiratory tract infections a) 2,257 cases selected by investigators b) 1,172 cases in which 5 laboratory examinations were performed New inclusion criteria require five laboratory examinations, i.e., microbiological study, white blood cell counts, stab count, C-reactive protein level and body temperature for the evaluation of new antimicrobial agents. Table 3. Comparison of the severity of the disease as judged by the investigator with that according to the new criteria a) Pharyngitis (170 cases) b) Tonsillitis (651 cases) * conformity rate: 45.2 % c) Bronchitis (697 cases)

Acute pharyngitis Body temperature White blood cell C-reactive protein Severity of infection Acute tonsillitis Body temperature White blood cell C-reactive protein Acute bronchitis Body temperature C-reactive protein Fig. 1. Distribution of body temperature, white blood cell counts and CRP levels in cases with acute pharyngitis (a), acute tonsillitis (b) or acute bronchitis (c) which received oral or parenteral antimicrobials classified by severity as judged by the investigators. Results are mean } 1 Ý. Data obtained from groups with less than 5 cases are not shown. Columns (,ƒ, ) indicate disease severity (mild, moderate and severe). Numbers in parenthesis under the number of cases which received oral or parenteral antimicrobials indicate the number of cases divided into the three degrees of severity (mild, moderate and severe).

Table 4. Distribution of cases in which clinical effectiveness assessed by investigators (A) was in agreement with that according to new criteria (B) a) 155 cases which fulfilled new inclusion criteria b) 79 cases which did not fulfill new inclusion criteria

DEC. 1998 Beam T R Jr., Gilbert D N, Kunin C M: General guidelines for the chinical evaluation of anti-infective drug products. Clin. Infect. Dis. 15 (Suppl. 1): S 5 `32, 1992 European Society of Clinical Microbiology and Infectious Disease: European guidelines for the clinical evaluation of anti-infective drug products 1993 Chow A W, Hall C B, Klein J 0, et al.: General guidelines for the evaluation of new anti-infective drugs for the treatment of respiratory tract infections. Clin. Infect. Dis. 15 (Suppl. 1): S 62 `88, 1992

Studies on general guidelines for the evaluation of new antimicrobial agents for the treatment of respiratory tract infections respiratory tract Akira Watanabe, Fumio Miki, Kotaro Ohizumi, Naoto Rikitomi, Hironobu Koga, Yoshihito Niki, Nobuchika Kusano and Atsushi Saito Committee for the Chinical Guidelines of New Antimicrobial Agents for the Treatment of Respirarory Tract Infections, Japan Society of Chemotherapy, 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan "General guidelines for the evaluation of the new antimicrobial agents for the treatment of res - piratory tract infections" was reported by our committee in the Japanese Journal of Chemotherapy ("General Guidelines" Vol. 45: 762 `778, 1997). The aim of the present paper is to discuss the validity of the above "General Guidelines", when applied for the study of the cases with acute upper respiratory tract infections (AURTI), and, if necessary, to set up a new guideline of the therapeutics of AURTI. For this purpose, a total of 2,257 cases with acute pharyngitis, acute tonsillitis or with acute bronchitis, which had been enlisted for the phase II and phase III clinical studies of new antimicrobials in Japan, were enrolled in the present study.most of them were selected and enrolled on the basis of the judgement by investigators, and 1,518 cases (67%) were found to fulfil the criteria of "General Guidelines". All of the 5 different measurements recommended by the ad hoc committee (microbial study, WBC counts, stab count, CRP level and body temperature) were done only in 1,172 enrolled cases, and 947 cases (81%) were found to fulfil the new diagnostic criteria. The degree of the severity of the disease judged by investigators differed somewhat each other between the per os medication cases and the parenteral medication cases, and the number of moderate cases was the largest.however, the number of mild cases was the largest according to the "General Guidelines". Of 1,518 cases which fulfilled the new criteria, the ratio of mild/moderate/severe cases by the judgement of investigators was 41/50/9 and that by the new criteria was 50/39/11. The ad hoc committee stated that laboratory examinations at the 7 th day after initiation of chemotherapy were "a must" for the correct evaluation of the effectiveness of antimicrobials administered. However, laboratory examinations at the 7 th day were done only in 234 cases, the judgemnt by investigators was comparable to that by the committee in 203 of 234 cases (87%). As a conclusion, the new guideline set up by the ad hoc committee is appropriate for the diagnosis, evaluation of severity of diseases, and for the evaluation of the effectiveness of antimicrobial agents used for the treatment of AURTI.

2026 © docsplayer.net プライバシー | 利用規約 | フィードバック