Toshiya CHIHARA,M.D. and Takakazu SHIBATA, M.D.

Toshiya CHIHARA,M.D. and Takakazu SHIBATA, M.D.

Fig. 1 Clinical Appearrance on the Head and Face of Case 1 on the First Arrival Fig. 2 Clinical Appearrance on the Shoulder and Arm of Case 1 on the First Arrival Fig. 3 Histopathological Finding of Case 1 (HE stain)

Fig. 4 Clinical Appearrance on the Head and Face of Case 1 at 2 Month Later Fig. 5 Clinical Appearrance on the Shoulder and Arm of Case 1 at 2 Month Later Fig. 6 Clinical Appearrance on the Frontal Scalp of Case 2

Fig. 7 Clinical Appearrance on the Forehead of Case 2 Fig. 8 Histopathological 2 (HE stain) Finding on the Frontal Scalp of Case Fig. 9 Histopathological Finding on the Forehead of Case 2 (HE stain)

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Two Cases of Cutaneous B-cell Lymphoma (CBCL) Toshiya Chihara and Takakazu Shibata Department of Dermatology, Hyogo Prefectural Kaibara Hospital 5208-1, Kaibara,Kaibara-cho, Hikami- gun, Hyogo 669-33, Japan Key words: cutaneous B-cell lymphoma, Ki-67, Ki-1, criteria We report 2 cases of cutaneous B-cell lymphoma (CBCL). The first case was 89 year old man. He had multiple tumor nodules on his head,face,shoulder and left arm.biopsy specimen showed B-cell malignant lymphoma. Searching surface antigens of tumor lymphocytes revealed Ki-67 (+), Ki-1(-). Therapies couldn't save him. The second case was 83 year old woman.she had a solitaly nodule on her frontal scalp. Biopsy spiecimen showed B-cell malignant lymphoma and Ki-67(+), Ki-1(+). Resection operation was carried out. After several month, we cannot find any signs of local recurrence. We think that today's classifications of malignant lymphomas are in kaos and not associated with their clinical features, indications of therapy and prognosis enough. In this paper we have to make it clear that Ki-67 is one of the best factors which is related to malignancy of tumors and that Ki-1 is one of the best factors which is related to a good prognosis. When we choose the therapy, we have to make the diagnosis not only by histopathological findings but by the fine observation of tumor growth speed considering patients'quality of life. Skin Research, 39:337-343, 1997