Keywords : ME1206, renal excretion, tubular secretion, transport system for anions, stop-flow analysis method, <I>p</I>-aminohippuric acid Renal excre

Similar documents
CHEMOTHERAPY MAY 1988


CHEMOTHERAPY APR Fig. 1 Chemical structure of cefotetan (CTT, YM09330)

CHEMOTHERAPY FEB Table 1 Background of volunteers



Jan THE JAPANESE JOURNAL OF ANTIBIOTICS XL-1 Table 1. Outline of administering doses, routes and sampling times *: 4 ml/hr/kg Bacillus subtilis

Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates


CHEMOTHERAPY Fig. 1 Chemical structure of CXM-AX

CHEMOTHERAPY Table 1 Urinary excretion of mezlocillin Fig. 4 Urinary excretion of mezlocillin Fig. 3 Blood levels of mezlocillin

Fig. 1. Structure of [methyl-14c]zonisamide


VOL.35 S-2 CHEMOTHERAPY Table 1 Sex and age distribution Table 2 Applications of treatment with carumonam Table 3 Concentration of carumonam in human

Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII (45)

coccus aureus Corynebacterium sp, Haemophilus parainfluenzae Klebsiella pneumoniae Pseudornonas aeruginosa Pseudomonas sp., Xanthomonas maltophilia, F

Experimental and Clinical Studies of Pregnant Hypertension Takashi SHIMAZU Department of Obstetrics and Gynecology, Osaka City University Medical Scho


VOL. 36 S-3 CHEMOTHERAPY 437

Fig. 1 Chemical structure of DL-8280

VOL.32 S-7 CHEMOTHERAPY Table 1 MIC of standard strains of CTRX Fig. 2 Cumulative curves of MIC S. aureus (26 strains )

Effect of Sympathetic and parasympathetic agents on cholesterol metabolism in mice salivary glands. Eriko, NEZU and Haruo, NAKAMURA (Department of Ora

VOL. 34 S-2 CHEMOTH8RAPY 913

CHEMOTHERAPY JUN Citrobacter freundii 27, Enterobacter aerogenes 26, Enterobacter cloacae 27, Proteus rettgeri 7, Proteus inconstans 20, Proteus


Table 1. Influence of food deprivation on gastric secretion and severity of ulceration in 18 hr pylorus ligated rats.

CHEMOTHERAPY APR. 1982

VOL.47 NO.5 Table 1. Susceptibility distribution of Ĉ- lactams against clinical isolates of MRSA MRSA: rnethicillin- resistant Staphylococcus aureus


CHEMOTHERAPY Fig. 1 Body weight changes of pregnant mice treated orally with AM- 715 Day of sestation

CHEMOTHERAPY NOV S. aureus, S. epidermidis, E. coli, K. pgeumoniae, E. cloacae, S. marcescens, P. mirabilis, Proteus, P. aeruginosa Inoculum siz

CHEMOTHERAPY Proteus mirabilis GN-79 Escherichia coli No. 35 Proteus vulgaris GN-76 Pseudomonas aeruginosa No. 11 Escherichia coli ML-1410 RGN-823 Kle

VOL. 37 NO. 3 Key words: Drug allergy, LMIT, Penams, Cephems, Cross-reactivity


CHEMOTHERAPY SEPT. 1992

CHEMOTHERAPY APR. 1984

Key words : 7432-S, Oral cephem, Urinary tract infection Fig. 1. Chemical structure of 7432-S.

CHEMOTHERAPY JUNE 1988 ( })-1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-l-piperaziny1) 4-oxo-3-quinolinecarboxylic acid hydrochloride Fig. 1. Chemica



untitled

CHEMOTHERAPY JUNE 1987 Table1 Media used *BHIB, brain heart infusion broth (Difco); /3 -NAD, S -nicotinamidoadeninedinucleotide (Sigma Chemical Co.);

VOL. 23 NO. 3 CHEMOTHERAPY 1067 Table 2 Sensitivity of gram positive cocci isolated from various diagnostic materials Table 3 Sensitivity of gram nega

CHEMOTHERAPY FEB Table 1. Activity of cefpirome and others against clinical isolates

_念3）医療2009_夏.indd

報告書 H22-2A-09

Introduction ur company has just started service to cut out sugar chains from protein and supply them to users by utilizing the handling technology of


CHEMOTHERAPY Fig. 1 Chemical structure of TE-031



epidermidis, Enterococcus faecalis, Enterococcus Klebsiella pneumoniae, Proteus mirabilis, indolepositive Proteus spp., Enterobacter spp., Serratia

CHEMOTHERAPY aureus 0.10, Enterococcus faecalis 3.13, Escherichia coli 0.20, Klebsiella pneumoniae, Enterobacter spp., Serratia marcescens 0.78, Prote

.\...pwd

untitled

Study on Application of the cos a Method to Neutron Stress Measurement Toshihiko SASAKI*3 and Yukio HIROSE Department of Materials Science and Enginee

CHEMOTHERAPY MAY. 1988

CHEMOTHERAPY APR Fig. 2 The inactivation of aminoglycoside antibiotics by PC-904 Fig. 3 Serum concentration of PC-904 (1) Fig. 4 Urinary recover


CHEMOTHERAPY

Table1MIC of BAY o 9867 against standard strains

明海大学歯学雑誌　３７‐２／１．秦泉寺

国土技術政策総合研究所　研究資料

Effect of Trimoprostil on Gastric Secretion Takeshi KAWAMURA * Hiroko EBINA * Fumiaki KOIZUMI * and Akira ISHIMORI * *Department of Clinical and Labor

総 説 6 6 PIMs P S J 7

CHEMOTHERAPY APR Fig. 1 Chemical structure of cefotetan (CTT, YM09 Molecular formula (Molecular weight) C17H15N7Na2OS4(619.57)

988 CHEMOTHERAPY NOV. 1971

206“ƒŁ\”ƒ-fl_“H„¤‰ZŁñ

Clostridium difficile ciprofloxacin, ofloxacin, norfloxacin Bifidobacterium Lactobacillus Lactobacillus Bacteroides fragilis B. fragilis C. difficile

Motivation and Purpose There is no definition about whether seatbelt anchorage should be fixed or not. We tested the same test conditions except for t

40B: Satoshi Shimai 1 and Shigehiro Fujimoto 2 1 Center for Liberal Arts and Education, Minami-Kyushu University, Miyakonojo,

VOL. 23 NO. 3 CHEMOTHERAPY 1379 Table 1 Susceptibility of clinical isolated strains to Tobramycin

CHEMOTHERAPY Table 1 Clinical effect of Sultamicillin


untitled

Fig. 1 Schematic construction of a PWS vehicle Fig. 2 Main power circuit of an inverter system for two motors drive

On the Wireless Beam of Short Electric Waves. (VII) (A New Electric Wave Projector.) By S. UDA, Member (Tohoku Imperial University.) Abstract. A new e


<95DB8C9288E397C389C88A E696E6462>

EQUIVALENT TRANSFORMATION TECHNIQUE FOR ISLANDING DETECTION METHODS OF SYNCHRONOUS GENERATOR -REACTIVE POWER PERTURBATION METHODS USING AVR OR SVC- Ju


VOL. 20 NO. 5 CHEMOTHERAPY Methoxy-4-sulfanilamidopyrimidine (OS-3376) Sulfadimethoxine (SDM) Table 1. In vitro antibacterial activities of OS-3

CHEMOTHERAPY

VOL.30 S-1 CHEMOTHERAPY Table 1 Antibacterial activity of CTT against standard strains Table 2 Antibacterial activity of CTT against standard strains

０１３８５８，繊維学会誌ファイバー１月／報文－０２－古金谷

Table 1. Clinical Background of Studied Cases.

202

Studies of Foot Form for Footwear Design (Part 9) : Characteristics of the Foot Form of Young and Elder Women Based on their Sizes of Ball Joint Girth



1. Precise Determination of BaAl2O4 Cell and Certification of the Formation of Iron Bearing Solid Solution. By Hiroshi UCHIKAWA and Koichi TSUKIYAMA (


CHEMOTHERAPY JUNE 1986

Visual Evaluation of Polka-dot Patterns Yoojin LEE and Nobuko NARUSE * Granduate School of Bunka Women's University, and * Faculty of Fashion Science,



..,,...,..,...,,.,....,,,.,.,,.,.,,,.,.,.,.,,.,,,.,,,,.,,, Becker., Becker,,,,,, Becker,.,,,,.,,.,.,,

Title 泌尿器科領域に於ける17-Ketosteroidの研究 17-Ketosteroidの臨床的研究 第 III 篇 : 尿 Author(s) 卜部, 敏入 Citation 泌尿器科紀要 (1958), 4(1): 3-31 Issue Date URL

原稿.indd

1272 CHEMOTHERAPY MAR. 1975

Transcription:

Keywords : ME1206, renal excretion, tubular secretion, transport system for anions, stop-flow analysis method, <I>p</I>-aminohippuric acid Renal excretion mechanism of ME1206, an active form of a novel oral cephalosporin antibiotic ME1207, in rats, rabbits and dogs. Takashi KURIBAYASHI, Jun-ichi OKAMOTO and Izumi KOMIYA Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760, Morooka-cho, Kohoku-ku, Yokohama 222, Japan Summary The renal excretion mechanism of ME1206, an active form of a novel oral cephalosporin antibiotic ME1207, was studied in rats using the renal clearance method and in rabbits and dogs applying the stop-flow analysis method. Excretion ratio (ER) was 3.64 in rats when ME1206 was administered alone. In contrast, the ER was 0.932 when the tubular secretion was inhibited by iodopyracet administered con comitantly. These results indicate that ME1206 is excreted into urine not only by the glome rular filtration but also by the tubular secretion in rats. In dogs, the ME1206 stop-flow pattern showed neither secretion nor reabsorption peak when ME1206 was administered with <I>p</I>-aminohippuric acid(pah) as a marker substance for prox imal tubular function. On the other hand, except for PAH, there was a small peak showing the tubular secretion. These results suggest that ME1206 is mainly excreted in dogs by the glomerular filtration with small contribution of the proximal tubular secretion. PAH inhibite d a weak secretion of ME1206 competing with the transport system for organic anions. In rabbits, there was an obvious secretion peak of ME1206 even in the presence of PAH. This peak disappeared completely by the coadministration of probenecid. Accordingly, ME 1206 is extensively secreted by the proximal tubules in addition to the glomerular filtration in rabbits. In summary, the mechanism of renal excretion of ME1206 differs among animal species. Moreover, it is suggested that the tubular secretion marker in the stop-flow analysis method should be substances which will be secreted by another transport system from that for the test substance.

Fig. 1 Chemical structures of ME 1207 (A) and ME1206 (B)

Table I HPLC conditions of ME1206, iodopyracet and p-aminohippuric acid (PAH)

Table 11 Effect of iodopyracet on the excretion ratio (ER) of ME1206 in rats

Fig. 2 Stop-flow pattern of ME1206 with p-aminohippuric acid in the dog before administration of probenecid ;... after administration of probenecid, (A) ME1206 ; (B) p-aminohippuric acid ; (C) Na ; (D) K ; (E) Creatinine ; (F) Inulin

Fig. 3 Stop-flow pattern of ME1206 without p-aminohippuric acid in the dog before administration of probenecid ;... after administration of probenecid, (A) ME 1206 ; (B) N a ; (C) K ; (D) Creatinine (E) Inulin

Fig. 4 Stop-flow pattern of ME1206 with p aminohippuric acid in the rabbit before administration of probenecid;..., after administration of probenecid, (A) ME 1206 ; (B) p-aminohippuric acid ; (C)Na ; (D)K ; (E)Creatinine; (F) Inulin

1) Tamura, A., Okamoto, R., Yoshida, T., Yamamoto, H., Kondo, S., Inoue, M. and Mitsuhashi, S. : In vitro and in vivo antibacterial activities of ME1207, a new oral cephalosporin. Antimicrob. Agents Chemother., 32: 1421-1426 (1988). 3) Shimada, J., Yamaji, T., Miyahara, T., Ueda, Y., Kawabata, T., Sugeno, K., Yoshida, T. and Nakamura, M.: Renal disposition of moxalactam in experimental animals as revealed by stop-flow analysis. Antimicrob. Agents Chemother., 23 : 8-14 (1983).

6) Inui, K., Okano, T., Takano, M., Kitazawa, S. and Hori, R.: Carrier mediated transport of amino-cephalosporins by brush border membrane - vesicles isolated from rat kidney cortex. Biochem. Pharmacol., 32 : 621 626 (1983). 7) Inui, K., Okano, T., Takano, M., Saito, H. and Hori, R. : Carrier-mediated transport of cephalexin via the dipeptide transport system in rat renal brush-border membrane vesicles. Biochim. Biophys. Acta, 769 : 449-454 (1984). 8) Dische, Z. and Borenfreund, E.: A new spectrophotometric method for detection and determination of keto sugars and trioses. J. Biol. Chem., 192: 583-587 (1951). 9) Malvin, R.L., Wilde, W.S. and Sullivan, L.P. : Localization of nephron transport by stop flow analysis. Am. J. Physiol., 194: 135-142 (1958). 10) Komiya, I.: Urine flow dependence of renal clearance and interrelation of renal reabsorption and physicochemical properties of drugs. Drug Metab. Dispos., 14 : 239-245 (1986). 11) Gower, P.E. and Dash, C.H. : The pharmacokinetics of cefuroxime after intravenous injection. Europ. J. clip. Pharmacol., 12 : 221-227 (1977). 12) Matsui, H. and Okuda, T. : Renal tubular mechanisms for excretion of cefpiramide(sm-1652) in association with its long-lasting pharmacokinetic properties. J. Pharmacobio-Dyn., 11 :67-73 (1988). 13) Yamazaki, I., Shirakawa, Y. and Fugono, T. : Comparison of the renal excretory mechanisms of cefmenoxime and other cephalosporins : effect of para-aminohippurate on renal clearance and intrarenal distribution of cephalosporins in rabbits. J. Antibiot., 34 : 1467-1485 (1981). -

2024 © docsplayer.net プライバシー | 利用規約 | フィードバック