260 250 200 150 10 100 50 0 1960 1965 1970 1975 1980 1985 1985 1995 2000 2005
25% 56% 66% 60%
90 80 70 60 50 40 30 20 10 0 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 4
1999 1990 2003 2005 2010 500,000 70,000 100,000 150,000 200,000 250,000 300,000 350,000 400,000 450,000 600,000 900,000 800,000 700,000 900,000 108,400 77,700 590,000 2001 2013 130,000 250,000 450,000
3.6 11.3 0.3 5.9 5.8 15.6 33.3 9.1 7.4 11.9 8.3 28.5 8.1 1.0 3.2 7.3 47.3 5.8 2.6 3.7 9.2 48.5 3.9 1.2 5.8
900 800 700 600 500 400 300 200 100 0 717 555 702 565 412 337 799 743 842 715 2005 2006 2007 2008 2009 721 697 2010
(Head and neck cancer)
88.2% 11.8% 17% 83% 81.8% 18.2% 14% 86% 93.5% 6.5% 17% 83% 94.7% 5.3% 49% 51%
6.5% 93.5% 17% 83% 18.2% 81.8% 14% 86% 11.8% 88.2% 17% 83% 5.3% 94.7% 49% 51%
(Lung cancer)
IA (T1N0M0) IB (T2N0M0) 72% 71% 50% 44% 10-20%
CT
Onishi H, et al. Cancer 101: 1623-1631, 2004
WJLCG RTOG9410 CALGB39801 BROCAT 20 LAMP GLOT CZECH 18 16 14 12 13.5M 15.5M 14.7M 16.6M 10
WJLCG GLOT CZECH 30 LAMP RTOG9410 BROCAT 25 20 15 10 5 p < 0.05 (Kruskal-Wallis test) 4% 23% 0
Hiroshima Trial of Chemotherapy And Radiotherapy Project; HTCARP
Elective Nodal Irradiation Involved Field Radiation Therapy
30M WJLCG GLOT CZECH 24 LAMP RTOG9410 BROCAT HTCARP 22 p < 0.05 (Kruskal-Wallis test) 20 18 16 14 14M 17M 12 10
WJLCG GLOT CZECH 30 25 20 15 10 5 0 LAMP RTOG9410 p < 0.05 (Kruskal-Wallis test) 4% BROCAT 23% 0% HTCARP
(Esophageal cancer)
Definitive Chamoradiotherapy for T4 and/or M1 Lymph Node Squamous Cell Carcinoma of the Esophagus Ohtsu A, et. al, J Clin Oncol 17: 2915-2921, 1999
ラ ン ダ ム 化 2008 ASCO annual meeting
2008 ASCO annual meeting
2008 ASCO annual meeting
登 録 Kato K, et al. Int J Radiat Biol Phys, in press
Kato K, et al. Int J Radiat Biol Phys, in press
Kato K, et al. Int J Radiat Biol Phys, in press
=
=
100 80 60 40 20 Unfavorable T1-3 PSA>10 Gleason7 81 Gy 3DCRT 75.6 Gy 3DCRT 64.8-70.2 Gy 3DCRT 0 0 12 24 36 48 60 72 84 96 108 Zelefsky MJ, et al. IMRT Workshop, 2001
20 75.6 Gy 3DCRT 15 81 Gy 3DCRT 10 64.8-70.2 Gy 3DCRT 5 81 Gy IMRT 0 0 24 48 72 96 Zelefsky MJ, et al. IMRT Workshop, 2001
3DCRT IMRT
Heidelberger Ionenstrahl-Therapie Therapie; ; HIT Heidelberg, Germany
% 100 80 60 40 20 0 p = 0.0063 0 20 40 60 80 100 120