Preg-82 2002.8
Ⅰ. Nakane Y et al.: Multi-institutional study on the teratogenecity and fetal toxitity of antiepileptic drugs: A report of a collabolative study group in Japan. Epilepsia, 21; 663-680,1980.
Ⅱ. Ⅲ. 16 Otani K: Risk factors for the increased seizure frequency during pregnancy and puerperium. Folia Psychiat Neurol Jpn 39:33-41,1985
Ⅳ. Ⅴ.
Ⅵ. Ⅶ. 1992
all or none 1
Ⅷ.. (Kaneko S.: Antiepileptic drug therapy and reproductive consequences: functional and morphologic effects. Reproductive Toxicol.,5;179-198,1991)
Ⅸ... (Kaneko S,et al.:malformation in infants of mothers with epilepsy receiving antiepileptic drugs.neurology, 42:68-74,1992)
. Kaneko S: Antiepileptic drug therapy and reproductive consequences: functional and morphologic effects. Reproductive Toxicol.5:179-198,1991 Gaily E: Minor anomalies in children of mothers with epilepsy. Neurology 42: 128-131,1992
Ⅹ. 317-341,1992
XI. 150mg/day 200mg/day 1,000mg/day 400mg/day
0.4mg 1g 0.5mg 5mg 4µg/l 1 2mg/day