1 1 Study on the effects of dexamethasone administration in acute coccidiosis accompanied by bloody stools TOMOYASU KUROSE Shoubara Veterinary Clinical Center, P. F. A. M. A. A -1-, Nishihonmachi, Shoubara, Hiroshima 77-13 SUMMARY Acute coccidiosis is accompanied by marked hemorrhage. Its symptoms often progress to pseudomembranous enteritis, which results in death or maldevelopment and complicates treatment. We recognized the importance of the anti-inflammatory and immunosuppressive effects of adrenocortical hormone and examined the effects of dexamethasone in acute coccidiosis accompanied by bloody stools. Treatment outcomes were examined employing medical records and compared among patients who received. mg/kg dexamethasone (Dex) or nonsteroidal anti-inflammatory drugs (NSAIDs) along with the conventional treatment, or the conventional treatment alone at the initial visit. Blood tests were conducted for the Dex group; acute-phase proteins, i.e., haptoglobin (Hp), 1 acid glycoprotein ( 1AG), and ceruloplasmin (Cp), were measured as inflammatory markers. The treatment results for the Dex group were better than those for the other two groups. Inhibiting immune overreaction by Dex administration could markedly suppress tissue damage and pseudomembrane formation, facilitating stronger therapeutic effects than the conventional methods and NSAIDs administration exhibiting strong anti-inflammatory effects. Symptoms at the initial visit included a decrease in the WBC count and increases in Hp and cortisol. However, cases detected earlier showed no marked increase in Hp, whose symptoms did not progress so markedly in spite of severe hemorrhage. Therefore, early Dex administration was considered to be effective for cases showing no increase in acute-phase proteins.
Dex.mg/kg NSAIDs Dex Hp1 1AG Cp Dex Dex NSAIDs Hp Hp Dex Dex 7 8 9 8 37.5 15. 1 Dex.mg/kg
Dex NSAIDs mg/kg NSAIDs 3 1 Dex NSAIDs 9 13 37.7 7. 37. 18. 37.5 17. 3 18 1 1 1 1 8 9 8 7 5 3 1 Dex Dex HtTP WBC Glu Hp1 1AG Cp Ht TP WBC Glu Hp 1 AG Cp SPOTCHEM VIDAS Dex 1 3 Dex 1.7.8 NSAIDs.7 1.5 3.1 3.8 Dex. 3.1 NSAIDs 13.1 7.5 9.5 11.3 p<.5 Dex.5.8 NSAIDs.8 1.8.5. p<.5 1 Dex Dex Ht Dex Glu Hp Dex 535. 39.8 g/ml 51.8 73.9 g/ml 1AG 151. 8. g/ml 193. 79.7 g/ml Cp 11..g/ml 38. 1.9 g/ml
3 1 Hp Hp 1AG Cp Dex 1 3 Dex 7 5 3 1 Dex n=5 1 3 (n=3) (n=) (n=1) Dex n=5 Ht.8.8. 3. WBC / l. 1953. 117. 7. Neut 5. 9.8 1. 1.8 8 7 5 3 1 P.1 Lym 73. 9.1 55..7 Mon.8 1.1 3..1 TP g/1ml 7.3. 7.3. Glu mg/1ml 17.8 1.5 15..5 Hp g/ml 535. 39.8 51.8 73.9 1 AG g/ml 151. 8. 193. 79.7 Cp g/ml 11.. 38. 1.9 Cortisol g/1ml 3.9 1.9 Hp 1AG Cp ( g/ml) NSAIDs A NSAIDs Dex Dex 1 IL-1 TNF Hp 1AG Cp Dex Hp 1AG Cp 3 3 Hp Hp Dex Hp
3 33 15 13 17 1997 1 1 Cynthia R. L. Webster, DVM, DACVIM 1 5 118 119 3 5 731 737 199 71 7 9 1 31 35 1 CAP 8 15 1 7