134 07ｨｺ08ｨ 07ｨｪ09ｨｹｨｺｨｨｨｦ ｨｪ02ｨｦ0806010608ｨｮ080006 ﾂｨｪｨｨｨｦ 03ｨｮ08ｨｪｨ 05, 014, 2006 0200050701060906 09ｨｰｨ ｨｰｨｰ06 070208 611.813.3ｨC018.46(048.8): 616ｨC089.843: 616.832+616.833ｨC001 0306ｨｰ02ｨｪ02ｨｨｨ 05ｨｹｨｪｨ 07 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 06ｨ 090605ｨ ｨｺｨｨ09ｨ 06ｨｴｨｨ01 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ0401 0005ｨｨ0602ｨｨｨｰ0609 09 09060909ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ06ｨｬ 0502 ﾂ02ｨｪｨｨｨｨ 070608ｨ 0302ｨｪｨｨ07 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ ｨｨ 070208ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ0208090609 0004ｨｬｨ ｨ 0506ｨｺ 00.06., 0502ｨｬ02ｨｪ0609ｨ 00.00., 08ｨｬｨｨｨｪ09ｨｺｨｨｨｦ 07.08., 0002010902010209 00.00. 06ｨｪ09ｨｰｨｨｨｰｨｮｨｰ ｨｪ02ｨｦ080601ｨｨ08ｨｮ0800ｨｨｨｨ ｨｨｨｬ. ｨ ｨｺｨ 01. 08.03. 0406ｨｬ0601ｨ ｨｪ0609ｨ 080001 07ｨｺ08ｨ ｨｨｨｪ04, 00. 08ｨｨ0209, 07ｨｺ08ｨ ｨｨｨｪｨ 04ｨ 0909ｨｬ06ｨｰ0802ｨｪ04 0906090802ｨｬ02ｨｪｨｪ0402 0708020109ｨｰｨ 090502ｨｪｨｨ07 06 00ｨｨ09ｨｰ06ｨ ｨｨ06050600ｨｨ ﾂ0209ｨｺｨｨ01 090906ｨｦ09ｨｰ09ｨ 01 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ0401 06ｨ 090605ｨ ｨｺｨｨ09ｨ 06ｨｴｨｨ01 0005ｨｨ0602ｨｨｨｰ0609 (020201) ｨｬ0502ｨｺ0607ｨｨｨｰｨ 06ｨｴｨｨ01. 07 ﾂｨｨｨｰ0409ｨ 07 09ｨ 03ｨｪｨｮ06 080605ｨｹ ｨｺ0502ｨｰ06ｨｺ 05ｨｰ060006 ｨｰｨｨ07ｨ 09 ｨｪｨ 0708ｨ 090502ｨｪｨｨｨｨ 080609ｨｰｨ ｨｪ02ｨｦ08ｨｨｨｰ0609 0902ｨｪ090608ｨｪ0401 ｨｪ02ｨｦ0806ｨｪ0609 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ060006 0507ｨｨｨｰ0205ｨｨ07 ｨｨ 06ｨ 02090702 ﾂ02ｨｪｨｨｨｨ ｨｨ01 0908ｨ 09ｨｰｨ ｨｪｨｨ07 09 ｨｰｨｺｨ ｨｪｨｹ 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ06ｨｦ 05ｨｮｨｺ0609ｨｨ0204, 09 05ｨｺ09070208ｨｨｨｬ02ｨｪｨｰ02 ｨｨ04ｨｮ ﾂ02ｨｪ04 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨ 070208090702ｨｺｨｰｨｨ0904 ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ 020201 010507 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨ07 070806090601ｨｨｨｬ0609ｨｰｨｨ 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ ｨｨ 070208ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ0208090609. 080506 ﾂ02090402 09050609ｨ : 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪｨ 07 05ｨｮｨｺ0609ｨｨ02ｨ, 06ｨ 090605ｨ ｨｺｨｨ09ｨ 06ｨｴｨｨ02 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ0402 0005ｨｨ0602ｨｨｨｰ04, ｨｪ02ｨｦ08060002ｨｪｨｪ0402 09ｨｰ09060506090402 ｨｺ0502ｨｰｨｺｨｨ, ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ07 ｨｺ0502ｨｰ06ｨｺ, ｨｰ08ｨ 09ｨｬｨ 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ. 05060902080302ｨｪ09ｨｰ090609ｨ ｨｪｨｨ02 ｨｬ02ｨｰ06010609 09060909ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ060006 0502 ﾂ02ｨｪｨｨ07 0706090802030102ｨｪｨｨ07 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ 01ｨｨｨｺｨｰｨｮ02ｨｰ ｨｪ0206ｨ 010601ｨｨｨｬ0609ｨｰｨｹ 0904ｨ 0608ｨ 05000002ｨｺｨｰｨｨ09ｨｪ0401 ｨｨ09ｨｰ06 ﾂｨｪｨｨｨｺ0609 ｨｺ0502ｨｰ06 ﾂｨｪ060006 ｨｬｨ ｨｰ0208ｨｨｨ 05ｨ 010507 ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ. 0201ｨｪｨｨｨｬ ｨｨ04 ｨｪ06090401 0706010106010609 09 05ｨｰ06ｨｦ 06ｨ 05ｨ 09ｨｰｨｨ 0709ｨｨ05ｨ 09ｨｹ 05ｨｺ09070208ｨｨｨｬ02ｨｪｨｰｨ 05ｨｹｨｪｨ 07 08ｨ 0408ｨ ｨ 06ｨｰｨｺｨ 0907060906ｨ 0609 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 020201 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ060006 ｨｰ08ｨ ｨｺｨｰｨ, ｨｺ06ｨｰ060804ｨｦ 09ｨｺ0506 ﾂｨ 02ｨｰ 010902 070607ｨｮ050702ｨｨｨｨ ｨｪ02ｨｦ08060002ｨｪｨｪ0401 09ｨｰ09060506090401 ｨｺ0502ｨｰ06ｨｺ (010508) ｪ 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ06ｨｦ 05ｨｮｨｺ0609ｨｨ0204 (0209) ｨｨ 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ06ｨｦ 0406ｨｪ04 ｨｪｨ 04ｨ 05ｨｹｨｪ060006 0507ｨｨｨｰ0205ｨｨ07. 00 ｨｪｨ 09ｨｰ0607ｨｴ0202 090802ｨｬ07 0209 08ｨ 0909ｨｬｨ ｨｰ08ｨｨ09ｨ 06ｨｰ ｨｺｨ ｨｺ 080204020809ｨｮｨ 08 ｨｪ02ｨｦ08060002ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ, ｨｺ06ｨｰ06080402 ｨｬｨｨ0008ｨｨ08ｨｮ06ｨｰ 09 ｨｪ0202 ｨｨ04 09ｨｮｨ 0902ｨｪｨｰ08ｨｨｨｺｨｮ050708ｨｪ06ｨｦ 0406ｨｪ04 ｨ 06ｨｺ06090401 030205ｨｮ0106 ﾂｨｺ0609 09 070609050201ｨｮ06ｨｴ02ｨｦ 01ｨｨ0000020802ｨｪ02ｨｨ080609ｨｺ06ｨｦ 09 040802050402 ｨｪ02ｨｦ080602ｨｨｨｰ04 [25, 38]. 03080201070605ｨ 00ｨ 06ｨｰ, ﾂｨｰ06 08ｨ 04ｨｬｨｪ060302ｨｪｨｪ0402 0708ｨｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨｨｨ ｨｪ02ｨｦ08060002ｨｪｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ 0209 ｨｨ05ｨｨ 0202 01ｨｨ0000020802ｨｪ02ｨｨ080609ｨ ｨｪｨｪ0402 010600ｨ ｨｬｨｨｨｪ020800ｨｨ ﾂ0209ｨｺｨｨ02 ｨｪ02ｨｦ0806ｨｪ04 ｨｬ0600ｨｮｨｰ ｨ 04ｨｰｨｹ ｨｨ09070605ｨｹ040609ｨ ｨｪ04 010507 ｨ ｨｮｨｰ06ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ, ｨｪｨ 0708ｨｨｨｬ0208, 0708ｨｨ 0502 ﾂ02ｨｪｨｨｨｨ 07ｨ 08ｨｺｨｨｨｪ0906ｨｪｨｨ04ｨｬｨ. 0102 ｨｬ02ｨｪ0202 070208090702ｨｺｨｰｨｨ09ｨｪ04ｨｬ ｨｨ09ｨｰ06 ﾂｨｪｨｨｨｺ06ｨｬ 070605ｨｮ- ﾂ02ｨｪｨｨ07 ｨｪ02ｨｦ0806ｨｺ0502ｨｰ06ｨｺ 010507 04ｨ ｨｬ0209ｨｰｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ 0709050702ｨｰ0907 070208ｨｨ000208ｨｨ ﾂ0209ｨｺｨ 07 ﾂｨ 09ｨｰｨｹ 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ060006 ｨ ｨｪｨ 05ｨｨ04ｨ ｨｰ0608ｨ ｪ 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪｨ 07 0406ｨｪｨ ｨｪｨ 04ｨ 05ｨｹｨｪ060006 0507ｨｨｨｰ0205ｨｨ07. 0306 0906090802ｨｬ02ｨｪｨｪ04ｨｬ 0708020109ｨｰｨ 090502ｨｪｨｨ07ｨｬ, 010508 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ060006 0507ｨｨｨｰ0205ｨｨ07 01ｨ 06ｨｰ ｨｪｨ ﾂｨ 0506 0902ｨｪ090608ｨｪ04ｨｬ ｨｪ02ｨｦ0806ｨｪｨ ｨｬ, 07060101020803ｨｨ09ｨ 06ｨｴｨｨｨｬ ｨｺ0502ｨｰｨｺｨ ｨｬ, ｨ ｨｰｨ ｨｺ0302 020201 [2], ｨｺ06ｨｰ06080402 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ04ｨｨ08ｨｮ06ｨｰ0907 ｨｰ06ｨｪｨｺｨｨｨｬｨｨ 02ｨｨｨｰ060705ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ 06ｨｰ080609ｨｰｨｺｨ ｨｬｨｨ, 06ｨｺｨｮｨｰ0409ｨ 06ｨｴｨｨｨｬｨｨ ｨ ｨｺ0906ｨｪ04 0902ｨｪ090608ｨｪ0401 ｨｪ02ｨｦ0806ｨｪ0609 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ060006 0507ｨｨｨｰ0205ｨｨ07 ｨｪｨ 090902ｨｬ 070806ｨｰ070302ｨｪｨｨｨｨ 0106 0908ｨ 09ｨｰｨ ｨｪｨｨ07 09 000506ｨｬ0208ｨｮ050708ｨｪ04ｨｦ 090506ｨｦ 0209 [28]. 06ｨｰｨｨ 0909060206ｨ 08ｨ 04ｨｪ0402 0005ｨｨｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ, 09070208090402 0607ｨｨ09ｨ ｨｪｨｪ0402 Golgi ｨｨ Blanes 09 ｨｺ06ｨｪ0202 XIX 09ｨｰ060502ｨｰｨｨ07 ｨｨ 070605ｨｮ ﾂｨｨ0903ｨｨ02 ｨｪｨ 0409ｨ ｨｪｨｨ02 ｰｨ 0502ｨｦｨｪ0209060909ｨｺ06ｨｦ 0005ｨｨｨｨ ｱ [31], 070802010706050603ｨｨｨｰ0205ｨｹｨｪ06 070806ｨｨ0901060107ｨｰ ｨｨ04 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ0401 0705ｨ ｨｺ0601. 060205ｨ 020201 08ｨ 09070605ｨ 00ｨ 06ｨｰ0907 ｨｺｨ ｨｺ 09 09050602 050000020802ｨｪｨｰｨｪ0401 09060506ｨｺ06ｨｪ 0209, ｨｰｨ ｨｺ ｨｨ 09 ｨ ｨ 04ｨ 05ｨｹｨｪ06ｨｦ ｨｬ02ｨｬｨ 08ｨ ｨｪ02 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ060006 0507ｨｨｨｰ0205ｨｨ07 [9, 22, 31]. 020201 ｨ ｨ 04ｨ 05ｨｹｨｪ06ｨｦ ｨｬ02ｨｬｨ 08ｨ ｨｪ04 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ060006 0507ｨｨｨｰ0205ｨｨ07 06ｨｰ05ｨｨ ﾂｨ 06ｨｰ0907 ｨ 06050202 090408ｨ 0302ｨｪｨｪ06ｨｦ 07080605ｨｨ000208ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 ｨｨ ｨｬｨｨ0008ｨ 02ｨｨ06ｨｪｨｪ06ｨｦ 0907060906ｨ ｨｪ0609ｨｰｨｹ06 in vitro [33]. 07 ﾂｨｨｨｰ0409ｨ 07, ﾂｨｰ06 ｨｪ02ｨｦ0806ｨｪ060002ｨｪ0204 09 070208ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 06ｨｰ010205ｨ 01 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ060006 ｨ ｨｪｨ 05ｨｨ04ｨ ｨｰ0608ｨ 070806ｨｨ09010601ｨｨｨｰ ｨｪｨ 070806ｨｰ070302ｨｪｨｨｨｨ 090902ｨｦ 03ｨｨ04ｨｪｨｨ ﾂ0205060902ｨｺｨ, 020201, 0706-09ｨｨ01ｨｨｨｬ06ｨｬｨｮ, 09050201ｨｮ02ｨｰ 08ｨ 0909ｨｬｨ ｨｰ08ｨｨ09ｨ ｨｰｨｹ ｨｺｨ ｨｺ 0201ｨｨｨｪ09ｨｰ0902ｨｪｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ 000105 090408060905060006 ﾂ0205060902ｨｺｨ, 06ｨ 02090702 ﾂｨｨ09ｨ 06ｨｴｨｨ02 ｨｪｨ 0708ｨ 090502ｨｪｨｪ04ｨｦ 080609ｨｰ ｨｬ060506010401 ｨ ｨｺ0906ｨｪ0609 09 0406ｨｪｨｮ 0902ｨｴ0209ｨｰ09ｨ ｨｬ060400ｨ. 06ｨｰｨ 060906ｨ 02ｨｪｨｪ0609ｨｰｨｹ 020201 07060905ｨｮ03ｨｨ05ｨ 0609ｨｪ0609ｨ ｨｪｨｨ02ｨｬ 010507 ｨｨｨｪｨｰ02ｨｪ09ｨｨ09ｨｪ060006 ｨｨ04ｨｮ ﾂ02ｨｪｨｨ07 ｨｨ01 090906ｨｦ09ｨｰ09 ｨｨ 0708060002ｨｪｨｨｨｰ0608ｨｪ060006 0706ｨｰ02ｨｪ02ｨｨｨ 05ｨ, ｨ ｨｰｨ ｨｺ0302 060202ｨｪｨｺｨｨ 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｨ01 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 09 09060909ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ06ｨｬ 0502 ﾂ02ｨｪｨｨｨｨ 0706090802030102ｨｪｨｨ07 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ. 0608ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ07 020201 010507 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨ07 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ 0708ｨｨ ｨｰ08ｨ 09ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｬ 0706090802030102ｨｪｨｨｨｨ. 00 ｨｪｨ 09ｨｰ0607ｨｴ0202 090802ｨｬ07 09 05ｨｺ09070208ｨｨｨｬ02ｨｪｨｰ02 ｨ ｨｺｨｰｨｨ09ｨｪ06 ｨｨ04ｨｮ ﾂｨ 02ｨｰ0907 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 020201 010507 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨ07 070806090601ｨｨｨｬ0609ｨｰｨｨ 0706090802030102ｨｪｨｪ0401 ｨｪ020809ｨｪ0401 09060506ｨｺ06ｨｪ 0708ｨｨ ｨｬ0201ｨ ｨｪｨｨ ﾂ0209ｨｺ06ｨｦ ｨｰ08ｨ 09ｨｬ02 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ ｨｨ 070208ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ0208090609. A. Ramon-Cueto ｨｨ 0906ｨ 09ｨｰ060804 [32] ｨｬ06010205ｨｨ080609ｨ 05ｨｨ ｨ ｨｪｨ ｨｰ06ｨｬｨｨ ﾂ0209ｨｺｨｨｨｦ 08ｨ 04080409 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ ｨｺ08040904 07ｨｮｨｰ02ｨｬ ｨｮ01ｨ 0502ｨｪｨｨ07 090200ｨｬ02ｨｪｨｰｨ TIX. 07 ﾂｨ 09ｨｰ06ｨｺ 0706090802030102ｨｪｨｨ07 06ｨｺｨｮｨｰ0409ｨ 05ｨｨ 09050602ｨｬ 09060201ｨｨｨｪｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨｰｨｺｨ ｨｪｨｨ ｨｨ 09090601ｨｨ05ｨｨ 020201 ｨｺｨ ｨｺ 09 06ｨ 08ｨ 040609ｨ 0903ｨｨｨｦ0907 01020002ｨｺｨｰ, ｨｰｨ ｨｺ ｨｨ 09 09ｨｬ0203ｨｪｨｮ06 ｨｰｨｺｨ ｨｪｨｹ 070806ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪ060006 ｨｨ 01ｨｨ09ｨｰｨ 05ｨｹｨｪ060006 ｨｮ ﾂｨ 09ｨｰｨｺ0609 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ.
130306ｨｰ02ｨｪ02ｨｨｨ 05ｨｹｨｪｨ 07 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 06ｨ 090605ｨ ｨｺｨｨ09ｨ 06ｨｴｨｨ01 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ0401 0005ｨｨ0602ｨｨｨｰ0609 ｭ 5 0709ｨｰｨ ｨｪ06090502ｨｪｨ 08020002ｨｪ0208ｨ 02ｨｨ07 ｨ ｨｺ0906ｨｪｨ 05ｨｹｨｪ0401 06ｨｺ06ｨｪ- ﾂｨ ｨｪｨｨｨｦ ｨｪ02ｨｦ0806ｨｪ0609 09 080609ｨｰ08ｨ 05ｨｹｨｪ06ｨｬ ｨｨ ｨｺｨ ｨｮ01ｨ 05ｨｹｨｪ06ｨｬ ｨｪｨ 0708ｨ 090502ｨｪｨｨ0701 ｨｪｨ 08ｨ 0909ｨｰ0607ｨｪｨｨ02 06ｨｺ060506 1,5 09ｨｬ 06ｨｰ 090606ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴｨｨ01 ｨｺ08ｨ 0209 ｨｺｨｮ05ｨｹｨｰ02ｨｦ 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ 09 07080608ｨ 09ｨｰｨ ｨｪｨｨ02ｨｬ ｨｪ02ｨｦ08ｨｨｨｰ0609 ﾂ02080204 09060201ｨｨｨｪｨｨｨｰ0205ｨｹｨｪ06ｨｰｨｺｨ ｨｪｨｪｨｮ06 06ｨ 060506 ﾂｨｺｨｮ 01020002ｨｺｨｰｨ. N. Keyvan-Foulad06 ｨｨ 0906ｨ 09ｨｰ060804 [15] ｨｨ09070605ｨｹ040609ｨ 05ｨｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ06 09ｨｮ090702ｨｪ04ｨｨｨｨ 020201 09 0706090802030102ｨｪｨｪ04ｨｦ ｨｮ ﾂｨ 09ｨｰ06ｨｺ 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ ｨｺ080409, ｨｮ ｨｺ06ｨｰ06080401 ﾂ02080204 2 ｨｬ0209 0706090502 ｨｬ06010205ｨｨ080609ｨ ｨｪｨｨ07 ｨｰ08ｨ 09ｨｬ04 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0602 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨ02 ｨｪ02 06ｨｰｨｬ02 ﾂ02ｨｪ06. 070302 09 ｨｰ02 ﾂ02ｨｪｨｨ02 1 ｨｪ0201 0706090502 ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ 020201 ｨｮ 03ｨｨ0906ｨｰｨｪ0401 ｨｮ05ｨｮ ﾂ03ｨ 050609ｨｹ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨｨ080609ｨ ｨｪｨｨ02 ｨｨ0709ｨｨ05ｨ ｨｰ0208ｨ 05ｨｹｨｪ0401 0706 06ｨｰｨｪ060302ｨｪｨｨ06 ｨｺ 0406ｨｪ02 070608ｨ 0302ｨｪｨｨ07 ｨｺ06ｨｪ02 ﾂｨｪ0609ｨｰ02ｨｦ. 05 ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨ02ｨｬ ｨｬ02ｨｰ0601ｨ ｨ ｨｺ0906ｨｪｨ 05ｨｹｨｪ060006 ｨｰ08ｨ ｨｪ09070608ｨｰｨ ｨｬ060502ｨｺｨｮ05 ｨ ｨｨ06ｨｰｨｨｨｪ0102ｨｺ09ｨｰ08ｨ ｨｪｨ ｨｮ09ｨｰｨ ｨｪ06090502ｨｪ06, ﾂｨｰ06 0706090802030102ｨｪｨｪ0402 ｨ ｨｺ0906ｨｪ04 ｨｺ0608ｨｰｨｨｨｺ060907ｨｨｨｪｨ 05ｨｹｨｪ060006 ｨｰ08ｨ ｨｺｨｰｨ 06ｨ 08ｨ 04ｨｮ06ｨｰ ｨｬ0609ｨｰｨｨｨｺｨｨ ﾂ02080204 0406ｨｪｨｮ 0706090802030102ｨｪｨｨ07, 07080608ｨ 09ｨｰｨ 06ｨｰ 09 ｨｺｨ ｨｮ01ｨ 05ｨｹｨｪ06ｨｬ ｨｪｨ 0708ｨ 090502ｨｪｨｨｨｨ ｨｪｨ 08ｨ 0909ｨｰ0607ｨｪｨｨ02 0106 10 ｨｬｨｬ ｨｨ 04ｨ ｨｺｨ ｨｪ ﾂｨｨ09ｨ 06ｨｰ0907 08ｨ 040902ｨｰ090502ｨｪｨｨ07ｨｬｨｨ 09 09020806ｨｬ 0902ｨｴ0209ｨｰ0902 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ. 0308ｨｨ 05ｨｰ06ｨｬ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ04ｨｦ 05000002ｨｺｨｰ 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨ07 ｨｪｨ ｨ 050601ｨ 05ｨｨ ｨｮ0302 0708ｨｨ 08020002ｨｪ0208ｨ 02ｨｨｨｨ 1% ｨ ｨｺ0906ｨｪ0609 ｨｺ0608ｨｰｨｨｨｺ060907ｨｨｨｪｨ 05ｨｹｨｪ060006 ｨｰ08ｨ ｨｺｨｰｨ, ﾂｨｰ06 070601ｨｰ0902080301ｨ 02ｨｰ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0402 ｨｺ06ｨｬ0702ｨｪ09ｨ ｨｰ0608ｨｪ0402 090604ｨｬ0603ｨｪ0609ｨｰｨｨ ｨｪ020809ｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04 00080404ｨｮｨｪ0609 [15]. 00.I. Chuah ｨｨ 0906ｨ 09ｨｰ060804 [7] ｨｨ09070605ｨｹ040609ｨ 05ｨｨ 010507 ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ 09 0406ｨｪｨｮ 0706090802030102ｨｪｨｨ07 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ ｨｺ08040904 0706090502 07020802080204ｨｺｨｨ 01060804ｨ 05ｨｹｨｪ0401 09ｨｰ0605ｨ 0609 ｨｪｨ ｨｮ080609ｨｪ02 TVIIIｨCTIX ｨｺｨ 0709ｨｮ0504 ｨｨ04 070608ｨｨ09ｨｰ060006 070605ｨｨｨｬ0208ｨ, ｨｪｨ 070605ｨｪ02ｨｪｨｪ0402 020201. ﾁ02080204 3 ｨｪ0201 ｨ 09ｨｰ060804 06ｨ ｨｪｨ 08ｨｮ03ｨｨ05ｨｨ 0601ｨｨｨｪ06 ﾂｨｪ0402 08020002ｨｪ0208ｨｨ08ｨｮ06ｨｴｨｨ02 ｨ ｨｺ0906ｨｪ04, 08ｨ 09070605060302ｨｪｨｪ0402 09ｨ 05ｨｨ04ｨｨ ｨｺｨ 0709ｨｮ05. 00 06ｨｰ05ｨｨ- ﾂｨｨ02 06ｨｰ 05ｨｰ060006, 0708ｨｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ 020201 ｨ 0204 ｨｪ0609ｨｨｨｰ020507 ｨｪｨ ｨ 050601ｨ 05ｨｨ 06ｨ 08ｨ 040609ｨ ｨｪｨｨ02 ｨｺ060505ｨ ｨｰ0208ｨ 05ｨｹｨｪ0401 08ｨ 040902ｨｰ090502ｨｪｨｨｨｦ 09060506ｨｺ06ｨｪ ｨｨｨｪｨｰｨ ｨｺｨｰｨｪ060006 0902ｨｪｨｰ08ｨ 05ｨｹｨｪ060006 ｨｺ0608ｨｰｨｨｨｺ060907ｨｨｨｪｨ 05ｨｹｨｪ060006 ｨｰ08ｨ ｨｺｨｰｨ 09 ｨｪｨ 0708ｨ 090502ｨｪｨｨｨｨ ｨｮ ﾂｨ 09ｨｰｨｺｨ 0909020102ｨｪｨｨ07 ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ ｨｰｨ. 0306 01ｨ ｨｪｨｪ04ｨｬ M.W. Richter ｨｨ 0906ｨ 09ｨｰ06080609 [33], 020201 ｨ ｨ 04ｨ 05ｨｹｨｪ06ｨｦ ｨｬ02ｨｬｨ 08ｨ ｨｪ04 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ060006 0507ｨｨｨｰ0205ｨｨ07 0708ｨｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ 09 0406ｨｪｨｮ ｨｮｨｪｨｨ05ｨ ｨｰ0208ｨ 05ｨｹｨｪ060006 0706090802030102ｨｪｨｨ07 04ｨ 01ｨｪ02ｨ 06ｨｺ06090401 06ｨｰ0102050609 ｨ 0205060006 0902ｨｴ0209ｨｰ09ｨ 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ 0708060709050706ｨｰ 070609040302ｨｪｨｪｨｮ06 0907060906ｨ ｨｪ0609ｨｰｨｹ ｨｺ ｨｬｨｨ0008ｨ 02ｨｨｨｨ, 09ｨｰｨｨｨｬｨｮ050702ｨｨｨｨ ｨ ｨｺ0906ｨｪｨ 05ｨｹｨｪ060006 080609ｨｰｨ ｨｨ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ06 08ｨ 04ｨｬ02080609 0406ｨｪ04 ｨｮ03ｨｨｨ ｨ. J. Lu ｨｨ 0906ｨ 09ｨｰ060804 [21] 0106ｨｺｨ 04ｨ 05ｨｨ 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨ 050506ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ 020205ｨｹｨｪ0401 ｨ 0506ｨｺ0609 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ06ｨｦ 0406ｨｪ04 ｨｪｨ 04ｨ 05ｨｹｨｪ060006 0507ｨｨｨｰ0205ｨｨ07 ｨｺ08040904 0708ｨｨ 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨｨｨ ｨ ｨｪｨ ｨｰ06ｨｬｨｨ ﾂ0209ｨｺ060006 08ｨ 04080409ｨ 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ. 0201ｨｪｨ ｨｺ06 ｨｪ02 ｨｮ09ｨｰｨ ｨｪ06090502ｨｪ06, 04ｨ 09 ﾂ02ｨｰ ｨｺｨ ｨｺｨｨ01 ｨｨｨｬ02ｨｪｨｪ06 ｨｺ0502ｨｰ06 ﾂｨｪ0401 050502ｨｬ02ｨｪｨｰ0609 ｨ 0405 010609ｨｰｨｨ00ｨｪｨｮｨｰ 0706050603ｨｨｨｰ0205ｨｹｨｪ04ｨｦ 05000002ｨｺｨｰ. 0201ｨｪｨｨｨｬ ｨｨ04 07080201070605060302ｨｪｨｨｨｦ 0709050702ｨｰ0907 090604ｨｬ0603ｨｪ0609ｨｰｨｹ 01ｨｨ0000020802ｨｪ02ｨｨ080609ｨｺｨｨ 0708060002ｨｪｨｨｨｰ06080609 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ060006 0507ｨｨｨｰ0205ｨｨ07 09 020201 0708ｨｨ 05ｨｺ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ 09 ｨｺｨｮ05ｨｹｨｰｨｮ08ｨ 05ｨｹｨｪ0401 ｨｮ09050609ｨｨ0701 ｨｨ05ｨｨ 0706090502 ｨｨ01 ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ 09 0406ｨｪｨｮ 08ｨ 04080409ｨ 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ [21, 38]. 01. Huang ｨｨ 0906ｨ 09ｨｰ060804 [13] 070806090205ｨｨ ｨｺ05ｨｨｨｪｨｨ- ﾂ0209ｨｺ0602 ｨｨ09090502010609ｨ ｨｪｨｨ02 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ 020201 09 0502 ﾂ02ｨｪｨｨｨｨ 0907ｨｨｨｪｨ 05ｨｹｨｪ06ｨｦ ｨｰ08ｨ 09ｨｬ04. 0608ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ06 020201 0609ｨｮｨｴ0209ｨｰ09050705ｨｨ 0906 090802ｨｬ07 06070208ｨ ｨｰｨｨ09ｨｪ0401 09ｨｬ0203ｨ ｨｰ0205ｨｹ09ｨｰ09, 07080201ｨｮ09ｨｬｨ ｨｰ08ｨｨ09ｨ 06ｨｴｨｨ01 ｨｮ09ｨｰ08ｨ ｨｪ02ｨｪｨｨ02 ｨｺ06ｨｬ0708020909ｨｨｨｨ 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ ｨｨ 09ｨｰｨ ｨ ｨｨ05ｨｨ04ｨ 02ｨｨ06 0706040906ｨｪ06 ﾂｨｪｨｨｨｺｨ. 02ｨｰｨｬ02 ﾂ02ｨｪ06 ｨｪ0204ｨｪｨ - ﾂｨｨｨｰ0205ｨｹｨｪ0602 ｨｮ05ｨｮ ﾂ0302ｨｪｨｨ02 ｨｪ02090806050600ｨｨ ﾂ0209ｨｺ060006 09ｨｰｨ ｨｰｨｮ09ｨ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09090201 09060408ｨ 09ｨｰｨｪ0401 0008ｨｮ0707. 0306-09ｨｨ01ｨｨｨｬ06ｨｬｨｮ, 0607080201020502ｨｪｨｪ0602 04ｨｪｨ ﾂ02ｨｪｨｨ02 ｨｨｨｬ0205ｨ 0105ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ 070208ｨｨ0601ｨ ｨｬ020301ｨｮ 090604ｨｪｨｨｨｺｨｪ060902ｨｪｨｨ02ｨｬ ｨｰ08ｨ 09ｨｬ04 ｨｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ02ｨｦ 020201. 0306 01ｨ ｨｪｨｪ04ｨｬ J.E. Collazos-Castro ｨｨ 0906ｨ 09ｨｰ06080609 [8], ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ07 020201 09 05ｨｺ09070208ｨｨｨｬ02ｨｪｨｰ02 06ｨｺｨ 04ｨ 05ｨ 09ｨｹ ｨｪ0205000002ｨｺｨｰｨｨ09ｨｪ06ｨｦ 0708ｨｨ ｨｰ08ｨ 09ｨｬ02 0302ｨｦｨｪ0401 06ｨｰ0102050609 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ ｨｺ08040904 (ｨｮ03ｨｨｨ ｨｪｨ ｨｮ080609ｨｪ02 090200ｨｬ02ｨｪｨｰｨ 05VII) ｨｨ ﾂｨ 09ｨｰ06 090607080609060301ｨ 05ｨ 09ｨｹ ｨ ｨｪ06ｨｬｨ 05ｨｹｨｪ04ｨｬ 080609ｨｰ06ｨｬ ｨ ｨｺ0906ｨｪ0609 09 06ｨ 08ｨ 040609ｨ ｨｪｨｨ02ｨｬ 0702ｨｰ0205ｨｹ. 00ｨｨ0008ｨ 02ｨｨ07 020201 04ｨ 07080201020504 0406ｨｪ04 0909020102ｨｪｨｨ07 ｨｨ05ｨｨ 07080608ｨ 09ｨｰｨ ｨｪｨｨ02 ｨ ｨｺ0906ｨｪ0609 ﾂ02080204 ｨｮ ﾂｨ 09ｨｰ06ｨｺ ｨｮ03ｨｨｨ ｨ 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ ｨｪ02 06ｨ ｨｪｨ 08ｨｮ0302ｨｪ04. V.M. Gomez ｨｨ 0906ｨ 09ｨｰ060804 [12] ｨｨ04ｨｮ ﾂｨｨ05ｨｨ 090604ｨｬ0603ｨｪ0609ｨｰｨｹ 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨ07 07020809ｨｨ ﾂｨｪ0401 ｨ 0000020802ｨｪｨｰ0609 04ｨ 01ｨｪｨｨ01 0806000609 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ 0904080609050401 ｨｺ080409 0706090502 05ｨｺ09070208ｨｨｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ06ｨｦ DREZ06ｨｰ06ｨｬｨｨｨｨ ｨｪｨ ｨｮ080609ｨｪ02 05IIIｨCTIII 07ｨｮｨｰ02ｨｬ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ 020201 09 0406ｨｪｨｮ 0706090802030102ｨｪｨｨ07. 05ｨｰ020702ｨｪｨｹ 08020002ｨｪ0208ｨ 02ｨｨｨｨ ｨ ｨｺ0906ｨｪｨ 05ｨｹｨｪ0401 06ｨｺ06ｨｪ ﾂｨ ｨｪｨｨｨｦ 060708020102050705ｨｨ 09 0706ｨｬ06ｨｴｨｹ06 0802ｨｰ08060008ｨ 01ｨｪ060006 ｨｬ02 ﾂ02ｨｪｨｨ07 0106050208ｨｪ04ｨｬ ｨｰ06ｨｺ09ｨｨｨｪ06ｨｬ 00, ｨ ｨｰｨ ｨｺ0302 05ｨｺ090708020909ｨｨｨｨ 070207ｨｰｨｨ01ｨ CGRP ｨｨ 07ｨｮ08ｨｨｨｪ060802020207ｨｰ0608ｨ 042093. 0809ｨｰ060804 ｨｮ09ｨｰｨ ｨｪ0609ｨｨ05ｨｨ, ﾂｨｰ06 CGRP- ｨｨ P2X3-0706050603ｨｨｨｰ0205ｨｹｨｪ0402 ｨ ｨｺ0906ｨｪ04 0905ｨ ｨ 06 07080608ｨ 09ｨｰｨ 05ｨｨ ﾂ02080204 ｨｮ ﾂｨ 09ｨｰ06ｨｺ 0706090802030102ｨｪｨｨ07, ｨｪ06 ｨｨ09ｨｺ0506 ﾂｨｨｨｰ0205ｨｹｨｪ06 ｨ 05ｨ 000601ｨ 0807 020201. 04020002ｨｪ0208ｨ 02ｨｨ06 ｨ ｨｺ0906ｨｪ0609 09 ｨｰ0605ｨｴ02 01060804ｨ 05ｨｹｨｪ060006 080600ｨ ｨｪ02 ｨｪｨ ｨ 050601ｨ 05ｨｨ, 0601ｨｪｨ ｨｺ06 0708ｨｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨｨｨ 020201 09ｨｬ0209ｨｰ02 09 ｨｪ020809ｨｪ04ｨｬｨｨ ｨｺ0502ｨｰｨｺｨ ｨｬｨｨ 0907ｨｨｨｪｨ 05ｨｹｨｪ0401 00ｨ ｨｪ0005ｨｨ0209 06ｨｰｨｬ02 ﾂｨ 05ｨｨ ｨｨｨｪｨｰ02ｨｪ09ｨｨ09ｨｪ04ｨｦ 080609ｨｰ ｨｪ02ｨｦ08ｨｨｨｰ0609. Y. Li ｨｨ 0906ｨ 09ｨｰ060804 [19] 0708ｨｨ09060107ｨｰ 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 05000002ｨｺｨｰｨｨ09ｨｪ060006 ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨ07 020201 010507 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨ07 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ 0706090502 DREZ06ｨｰ06ｨｬｨｨｨｨ. 0709ｨｰｨ ｨｪ06090502ｨｪ06, ﾂｨｰ06 020201 06ｨ 050200 ﾂｨ 06ｨｰ 0908ｨ 09ｨｰｨ ｨｪｨｨ02 ｨ ｨｺ0906ｨｪ0609 09 ｨｰｨｺｨ ｨｪｨｹ 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ. 00 ｨｰ06 0302 090802ｨｬ07, L.M. Ramer ｨｨ 0906ｨ 09ｨｰ060804 [29] ｨｮ09ｨｰｨ ｨｪ0609ｨｨ05ｨｨ, ﾂｨｰ06 ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ07 020201 ｨｨ04 ｨ ｨ 04ｨ 05ｨｹｨｪ06ｨｦ ｨｬ02ｨｬｨ 08ｨ ｨｪ04 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ060006 0507ｨｨｨｰ0205ｨｨ07 ｨｬ0403ｨｨ ｨｪ02 0706ｨｰ02ｨｪ02ｨｨ08ｨｮ02ｨｰ 07080608ｨ 09ｨｰｨ ｨｪｨｨ02 ｨ ｨｺ0906ｨｪ0609 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0401 ｨｪ02ｨｦ0806ｨｪ0609 0907ｨｨｨｪｨｪ06ｨｬ06040006090401 ｨｮ04050609 ｨｺ08040904 0706090502 DREZ06ｨｰ06ｨｬｨｨｨｨ. 06ｨｰｨｨ ｨｪ02ｨｮ01ｨ ﾂｨｪ0402 07060704ｨｰｨｺｨｨ 06ｨ ｨｮ09050609ｨｨ05ｨｨ ｨｪ0206ｨ 010601ｨｨｨｬ0609ｨｰｨｹ 08ｨ 0408ｨ ｨ 06ｨｰｨｺｨｨ ｨｪ06090401 0706010106010609 ｨｺ 08020302ｨｪｨｨ06 070806ｨ 0502ｨｬ04 ｨ ｨｪｨ ｨｰ06ｨｬｨｨ ﾂ0209ｨｺ060006 ｨｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ060006 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨ07 0706090802030102ｨｪｨｪ060006 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ 07ｨｮｨｰ02ｨｬ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ. 06ｨ ｨｺ, 010507 09060401ｨ ｨｪｨｨ07 ｨｮ09050609ｨｨｨｦ 0105ｨｨｨｰ0205ｨｹｨｪ060006 ｨｮ01020803ｨｨ09ｨ ｨｪｨｨ07 09ｨｮ090702ｨｪ04ｨｨｨｨ 020201 09 ｨｬ0209ｨｰ02 0202 0909020102ｨｪｨｨ07 09 07ｨ ｨｰ06050600ｨｨ ﾂ0209ｨｺｨｨｨｦ 06 ﾂｨ 00 09 ｨｪｨ 09ｨｰ0607ｨｴ0202 090802ｨｬ07 08ｨ 0408ｨ ｨ ｨ ｨｰ0409ｨ 06ｨｰ 09070202ｨｨｨ 05ｨｹｨｪ0402 070605ｨｨｨｬ0208ｨｪ0402 ｨｪ0609ｨｨｨｰ0205ｨｨ 010507
136 0004ｨｬｨ ｨ 0506ｨｺ 00.06., 0502ｨｬ02ｨｪ0609ｨ 00.00., 08ｨｬｨｨｨｪ09ｨｺｨｨｨｦ 07.08., 0002010902010209 00.00. ｨｺ0502ｨｰ06 ﾂｨｪ0401 ｨｬｨｨｨｺ09ｨｰ0609 ｨｨ 00ｨ ｨｺｨｰ06080609 080609ｨｰｨ. 03080201070605ｨ 00ｨ 06ｨｰ, ﾂｨｰ06 05ｨｰｨｨ 0708ｨｨ02ｨｬ04 ｨ ｨｮ01ｨｮｨｰ 0907060906ｨ 09ｨｰ090609ｨ ｨｰｨｹ 0607ｨｰｨｨｨｬｨｨ04ｨ 02ｨｨｨｨ 0706050603ｨｨｨｰ0205ｨｹｨｪ060006 0906040102ｨｦ09ｨｰ09ｨｨ07 020201 ｨｪｨ 09060909ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ0402 0708060202090904 09 0406ｨｪ02 0706090802030102ｨｪｨｨ07 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ. 04ｨ ｨ 06ｨｰ04 09 05ｨｰ06ｨｬ ｨｪｨ 0708ｨ 090502ｨｪｨｨｨｨ 09 ｨｪｨ 09ｨｰ0607ｨｴ0202 090802ｨｬ07 ｨ ｨｺｨｰｨｨ09ｨｪ06 090201ｨｮｨｰ0907. 01ｨ 0708ｨｨｨｬ0208, L.N. Novikova ｨｨ 0906ｨ 09ｨｰ060804 [24] ｨｮ09ｨｰｨ ｨｪ0609ｨｨ05ｨｨ, ﾂｨｰ06 ｨ ｨｨ06070605ｨｨｨｬ0208ｨｪ04ｨｦ ｨｬｨ ｨｰ08ｨｨｨｺ09ｨｪ04ｨｦ 07080207ｨ 08ｨ ｨｰ, 070609ｨｰ080602ｨｪｨｪ04ｨｦ ｨｪｨ 0609ｨｪ060902 ｨ 05ｨｹ00ｨｨｨｪｨ ｨｰｨｪ0401 00ｨｨ01080600020502ｨｦ ｪ ｨｬｨ ｨｰ08ｨｨ000205ｨｹ ｨｨｨｪ01ｨｮ02ｨｨ08ｨｮ02ｨｰ ｨｬｨ 0909ｨｨ09ｨｪ04ｨｦ 090708ｨ ｨｮｨｰｨｨｨｪ00 ｨｪ02ｨｦ0806ｨｪ0609 0907ｨｨｨｪｨ 05ｨｹｨｪ0401 00ｨ ｨｪ0005ｨｨ0209 in vitro 09 0708ｨｨ09ｨｮｨｰ09ｨｰ09ｨｨｨｨ 020201 ｨｨ 0605ｨｨ00060102ｨｪ01080602ｨｨｨｰ0609. 06000002ｨｺｨｰｨｨ09ｨｪ04ｨｬ ｨｬ02ｨｰ060106ｨｬ 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨ07 0706090802030102ｨｪｨｪ060006 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ 09 ﾂｨｨｨｰｨ 06ｨｰ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ06 020201 ｨｨ 0605ｨｨ00060102ｨｪ01080602ｨｨｨｰ0609 ﾂ02080204 1 ｨｪ0201 0706090502 ｨｰ08ｨ 09ｨｬ04 ｨｪｨ 0006ｨｪ02 0909020102ｨｪｨｨ07 ｨｬ02ｨｰｨｨ0507080201ｨｪｨｨ04060506ｨｪｨ ｨｨ ｨｨｨｪｨｰ02080502ｨｦｨｺｨｨｨｪｨ -12 09 0609ｨｰ0806ｨｬ 070208ｨｨ060102 ｨｰ08ｨ 09ｨｬ04 [26]. 0306 ｨｬｨｪ02ｨｪｨｨ06 ｨｨ09090502010609ｨ ｨｰ020502ｨｦ, 0607ｨｰｨｨｨｬｨ 05ｨｹｨｪ04ｨｬ 010507 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨ ｨｺ0906ｨｪｨ 05ｨｹｨｪ060006 080609ｨｰｨ 09 ｨｺｨｮ05ｨｹｨｰｨｮ0802 0709050702ｨｰ0907 ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨ02 0002ｨｰ0208060002ｨｪ06ｨｰｨｨ07ｨｨ ﾂ0209ｨｺｨｨ01 ｨｺｨｮ05ｨｹｨｰｨｮ08 020201, 09ｨｺ0506 ﾂｨ 06ｨｴｨｨ01 0875-0706050603ｨｨｨｰ0205ｨｹｨｪ0402 ｨｨ 0875-06ｨｰ08ｨｨ02ｨ ｨｰ0205ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ [16]. 0308ｨｨ 05ｨｰ06ｨｬ 0708ｨｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ 020201 ｨｪｨ ｨｬ06010205ｨｨ ｨｬ0201ｨ ｨｪｨｨ ﾂ0209ｨｺ06ｨｦ ｨｰ08ｨ 09ｨｬ04 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 ｨ 09ｨｰ080602ｨｨｨｰｨ 08ｨｪ06ｨｦ 0005ｨｨｨｨ ｨｨ 09ｨｨｨｪｨｰ0204 0106ｨｪ010806ｨｨｨｰｨｨｨｪ09ｨｮ05ｨｹ00ｨ ｨｰ0609 ｨｬ02ｨｪ0202 090408ｨ 0302ｨｪ04, ﾂ02ｨｬ 0909020102ｨｪｨｨ02 ｨｺ0502ｨｰ06ｨｺ 0605ｨｨ00060102ｨｪ0108060005ｨｨｨｨ [17]. 030605ｨｰ06ｨｬｨｮ K. Fouad ｨｨ 0906ｨ 09ｨｰ060804 [10] 0708020105ｨ 00ｨ 06ｨｰ 09090601ｨｨｨｰｨｹ 09 ｨｮ ﾂｨ 09ｨｰ06ｨｺ 0706090802030102ｨｪｨｨ07 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ 020201 09 ｨｺ06ｨｬ070502ｨｺ0902 09 ｨｺ0502ｨｰｨｺｨ ｨｬｨｨ 0605ｨｨ00060102ｨｪ0108060005ｨｨｨｨ ｨｨ 0106ｨｪ010806ｨｨｨｰｨｨｨｪｨ 0404 080005. 06ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 09 ｨｪｨ 09ｨｰ0607ｨｴ0202 090802ｨｬ07 070208090702ｨｺｨｰｨｨ09ｨｪ04ｨｬ 09ｨ 08ｨｨｨ ｨｪｨｰ06ｨｬ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ 0708ｨｨ 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨｨｨ 070806090601ｨｨｨｬ0609ｨｰｨｨ 0706090802030102ｨｪｨｪ060006 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ 09 ﾂｨｨｨｰｨ 06ｨｰ 0909020102ｨｪｨｨ02 ｨｺ0502ｨｰ06 ﾂｨｪ0401 ｨｬｨｨｨｺ09ｨｰ0609 ｨｨ 090607ｨｮｨｰ09ｨｰ09ｨｮ06ｨｴｨｨ01 ｨｰ080600ｨｨ ﾂ0209ｨｺｨｨ01 00ｨ ｨｺｨｰ06080609 09 ｨｺ06ｨｬ070502ｨｺ0902 09 ｨｨ09ｨｺｨｮ0909ｨｰ0902ｨｪｨｪ04ｨｬｨｨ 070605ｨｨｨｬ0208ｨｪ04ｨｬｨｨ ｨｪ0609ｨｨｨｰ020507ｨｬｨｨ. 06000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ 020201 ｨｪｨ ｨｬ06010205ｨｨ ｨｰ08ｨ 09ｨｬ04 070208ｨｨ000208ｨｨ ﾂ0209ｨｺ060006 ｨｪ020809ｨ. 0608ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ07 020201 ｨｬ060302ｨｰ 06ｨｺｨ 04ｨ ｨｰｨｹ0907 05000002ｨｺｨｰｨｨ09ｨｪ06ｨｦ ｨｰｨ ｨｺ0302 0708ｨｨ 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨｨｨ 0202050609ｨｰｨｪ0609ｨｰｨｨ 070208ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ0208090609. S.Y. Cheng ｨｨ 0906ｨ 09ｨｰ060804 [5] 0706090502 07020802080204ｨｺｨｨ 090201ｨ 05ｨｨｨｴｨｪ060006 ｨｪ020809ｨ 09ｨ 05ｨｨ03ｨ 05ｨｨ ｨｨ 00ｨｨｨｺ09ｨｨ080609ｨ 05ｨｨ 020006 070806ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪｨｮ06 ｨｨ 01ｨｨ09ｨｰｨ 05ｨｹｨｪｨｮ06 ﾂｨ 09ｨｰｨｨ. 020201 09090601ｨｨ05ｨｨ 09 07080609ｨｰ08ｨ ｨｪ09ｨｰ0906 ｨｬ020301ｨｮ ｨｺｨｮ05ｨｹｨｰ07ｨｬｨｨ ｨｪ020809ｨ ｨｨ ﾂ02080204 30 ｨｨ 90 09ｨｮｨｰ ｨｨ04ｨｮ ﾂｨ 05ｨｨ 020006 050502ｨｺｨｰ08ｨｨ ﾂ0209ｨｺｨｮ06 070806090601ｨｨｨｬ0609ｨｰｨｹ. 0709ｨｰｨ ｨｪ06090502ｨｪ06 ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 07080601060503ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ 05ｨ ｨｰ02ｨｪｨｰｨｪ060006 070208ｨｨ0601ｨ 05000804, ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 09ｨｺ06080609ｨｰｨｨ 07080609020102ｨｪｨｨ07 ｨｨ ｨ ｨｬ0705ｨｨｨｰｨｮ0104 050502ｨｺｨｰ08ｨｨ ﾂ0209ｨｺ060006 090604ｨ ｨｮ030102ｨｪｨｨ07, ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 ｨｺ0605ｨｨ ﾂ0209ｨｰ09ｨ HRP-0706050603ｨｨｨｰ0205ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 05ｨ ｨｰ0208ｨ 05ｨｹｨｪ060006 070108ｨ 0702080201ｨｪ020006 080600ｨ 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ ｨｨ ｨｪ020809ｨｪ0401 09060506ｨｺ06ｨｪ ｨｪｨ 0201ｨｨｨｪｨｨ02ｨｮ 070506ｨｴｨ 01ｨｨ 070607020802 ﾂｨｪ060006 0902 ﾂ02ｨｪｨｨ07 ｨｪ020809ｨ, ｨ ｨｰｨ ｨｺ0302 ｨｮｨｰ0605ｨｴ02ｨｪｨｨ02 ｨｬｨｨ0205ｨｨｨｪ06090401 06ｨ 060506 ﾂ02ｨｺ ｨ ｨｺ0906ｨｪ0609 0106 0,63 ｨｬｨｺｨｬ. Y. L06 ｨｨ 0906ｨ 09ｨｰ060804 [20] ｨｨ09070605ｨｹ040609ｨ 05ｨｨ 020201 010507 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨ07 0202050609ｨｰｨｪ0609ｨｰｨｨ 0408ｨｨｨｰ0205ｨｹｨｪ060006 ｨｪ020809ｨ 040802050401 ｨｺ080409 0706090502 ｨｬ06010205ｨｨ080609ｨ ｨｪｨｨ07 070605ｨｪ060006 09ｨｪｨｮｨｰ08ｨｨ0608ｨ ｨｨｨｰｨ 05ｨｹｨｪ060006 08ｨ 04080409ｨ. 02 ﾂｨｨｨｴ02ｨｪｨｪ0402 020201 ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨｨ080609ｨ 05ｨｨ 09 070806ｨｬ0203ｨｮｨｰ06ｨｺ ｨｬ020301ｨｮ 09ｨ 05ｨｨ0302ｨｪｨｪ04ｨｬｨｨ ｨｺ06ｨｪ02ｨ ｨｬｨｨ ｨｪ020809ｨ. ﾁ02080204 6 ｨｬ0209 0802ｨｰｨｨｨｪｨ 05ｨｹｨｪ0402 ｨ ｨｺ0906ｨｪ04 09 09060708060906030102ｨｪｨｨｨｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨｨ080609ｨ ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 07080608ｨ 09ｨｰｨ 05ｨｨ 09 070806ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪｨｮ06 ｨｺｨｮ05ｨｹｨｰ06 ｨｪ020809ｨ ｨｪｨ 10 ｨｬｨｬ ｨｨ 04ｨ ｨｺｨ ｨｪ ﾂｨｨ09ｨ 05ｨｨ09ｨｹ 08ｨ 0903ｨｨ0802ｨｪｨｨ07ｨｬｨｨ, 04ｨ ｨｺ06ｨｰ060804ｨｬｨｨ ｨｪｨ ｨ 050601ｨ 05ｨｨ ｨ ｨｰ080600ｨｨ06 0408ｨｨｨｰ0205ｨｹｨｪ060006 ｨｪ020809ｨ 09 ｨｰｨｨ07ｨｨ ﾂｨｪ04ｨｬ ｨ 09ｨｰ08060005ｨｨ060406ｨｬ. 06000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ 020201 ｨｪｨ ｨｬ06010205ｨｨ 0102ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨｨｨ 09 0907ｨｨｨｪｨｪ06ｨｬ ｨｬ06040002. 07 ﾂｨ 09ｨｰｨｨ02 020201 09 0802ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨｨｨ 09060506ｨｺ06ｨｪ 0706090802030102ｨｪｨｪ060006 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ. 0608ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ07 020201 05000002ｨｺｨｰｨｨ09ｨｪｨ ｨｨ 09 0502 ﾂ02ｨｪｨｨｨｨ 0102ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨｨ08ｨｮ06ｨｴｨｨ01 04ｨ ｨ 06050209ｨ ｨｪｨｨｨｦ 09 05ｨｺ09070208ｨｨｨｬ02ｨｪｨｰ02. 06ｨ ｨｺ, S.C. Barnett ｨｨ 0906ｨ 09ｨｰ060804 [1] 0706ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ06 020201, ｨｨ040605ｨｨ080609ｨ ｨｪｨｪ0402 ｨｨ04 0209 ﾂ0205060902ｨｺｨ, ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｰ 09 0802ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨｨｨ ｨ ｨｺ0906ｨｪ0609 ｨｮ ｨｺ080409 0706090502 0708020109ｨ 08ｨｨｨｰ0205ｨｹｨｪ06ｨｦ 0102ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨｨｨ 07ｨｮｨｰ02ｨｬ 0906040102ｨｦ09ｨｰ09ｨｨ07 0802ｨｪｨｰ0002ｨｪ060909ｨｺ060006 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 ｨｪｨ 0006ｨｪ02 0909020102ｨｪｨｨ07 05ｨｰｨｨ01ｨｨ07 ｨ 0806ｨｬｨｨ01ｨ. 01ｨ ｨ ｨｪｨ 050600ｨｨ ﾂｨｪ06ｨｦ ｨｬ06010205ｨｨ 0102ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨｨｨ T. Imaizumi ｨｨ 0906ｨ 09ｨｰ060804 [14] ｨｮ09ｨｰｨ ｨｪ0609ｨｨ05ｨｨ, ﾂｨｰ06 020201-04ｨ 09ｨｨ09ｨｨｨｬｨ 07 ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨ07 ｨ ｨｺ0906ｨｪ0609 0706090802030102ｨｪｨｪ060006 ｨｬ060400ｨ 06ｨ ｨｮ0905060905ｨｨ09ｨ 02ｨｰ ｨｮ05ｨｮ ﾂ0302ｨｪｨｨ02 0706ｨｺｨ 04ｨ ｨｰ020502ｨｦ ｨ ｨｺ0906ｨｪｨ 05ｨｹｨｪ06ｨｦ 070806090601ｨｨｨｬ0609ｨｰｨｨ 050502ｨｺｨｰ08ｨｨ ﾂ0209ｨｺ060006 090604ｨ ｨｮ030102ｨｪｨｨ07. 05. Radtke ｨｨ 0906ｨ 09ｨｰ060804 [27] 0609ｨｮｨｴ0209ｨｰ09050705ｨｨ ｨｺ0902ｨｪ060002ｨｪｨｪｨｮ06 ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ06 09040906ｨｺ06 06 ﾂｨｨｨｴ02ｨｪｨｪ0401 020201 09 ｨｮ ﾂｨ 09ｨｰ06ｨｺ 0102ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨｨｨ 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ ｨ 0008ｨｨｨｺｨ ｨｪ09ｨｺｨｨ01 04020502ｨｪ0401 06ｨ 0204ｨｹ07ｨｪ06ｨｺ. 0102ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ ｨｬ0601ｨｨ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0402 020201, ｨｺ06ｨｰ06080402 070605ｨｮ ﾂｨ 05ｨｨ ｨｨ04 0209 0909ｨｨｨｪｨｹｨｨ, 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ04ｨｨ080609ｨ 05ｨｨ09ｨｹ ｨｺ06ｨｪ09ｨｰｨｨｨｰｨｮ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ 05ｨｺ090708020909ｨｨ02ｨｦ 0002ｨｪｨ H-ｨｰ08ｨ ｨｪ09000208ｨ 0404. ﾁ02080204 1 ｨｬ0209 0706090502 ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ｨｮ 62,5% 03ｨｨ0906ｨｰｨｪ0401 ｨｪｨ ｨ 050601ｨ 05ｨｨ 090408ｨ 0302ｨｪｨｪｨｮ06 0802ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨ06. 0306 01ｨ ｨｪｨｪ04ｨｬ ｨｨｨｬｨｬｨｮｨｪ0600ｨｨ09ｨｰ0601ｨｨｨｬｨｨ ﾂ0209ｨｺ060006 ｨｨ09090502010609ｨ ｨｪｨｨ07 0802ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨ07 ｨｪ020809ｨｪ0401 09060506ｨｺ06ｨｪ 0609ｨｮｨｴ0209ｨｰ09050705ｨ 09ｨｹ ｨ 05ｨ 000601ｨ 0807 020201. 0201ｨｪｨ ｨｺ06 080605ｨｹ 020201 09 000608ｨｬｨｨ080609ｨ ｨｪｨｨｨｨ ｨｬｨｨ0205ｨｨｨｪｨ 09070608ｨｪｨ. M. Sasaki ｨｨ 0906ｨ 09ｨｰ060804 [34] ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨｨ080609ｨ 05ｨｨ 020201, ｨｬ02 ﾂ02ｨｪｨｪ0402 0002ｨｪ06ｨｬ ｨ 0205ｨｺｨ 04020502ｨｪ06ｨｦ 0005ｨｮ060802090202ｨｪ02ｨｨｨｨ, 09 06ｨ 05ｨ 09ｨｰｨｹ 07020802080204ｨｺｨｨ 04ｨ 01ｨｪ020006 ｨｺｨ ｨｪｨ ｨｰｨｨｨｺｨ 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ ｨｺ08040904. 0308ｨｨ ｨｨ04ｨｮ ﾂ02ｨｪｨｨｨｨ 08ｨ 0907080201020502ｨｪｨｨ07 ｨｬ02 ﾂ02ｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 09 06ｨ 05ｨ 09ｨｰｨｨ 0706090802030102ｨｪｨｨ07 ﾂ02080204 5 ｨｪ0201 0706090502 ｨｰ08ｨ 09ｨｬ04 ｨｮ09ｨｰｨ ｨｪ06090502ｨｪ06, ﾂｨｰ06 020201 ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｰ 09 ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨｨｨ ｨ ｨｺ0906ｨｪ0609, 07080608ｨ 09ｨｰｨ 06ｨｴｨｨ01 09 ｨｨ01 0706ｨｬ06ｨｴｨｹ06 ﾂ02080204 0406ｨｪｨｮ 07020802080204ｨｺｨｨ. 00 070806ｨｰｨｨ09060706050603ｨｪ0609ｨｰｨｹ 05ｨｰ06ｨｬｨｮ, J.G. Boyd ｨｨ 0906ｨ 09ｨｰ060804 [4], ｨｨ09070605ｨｹ04ｨｮ07 ｨｬ02 ﾂ02ｨｪｨｨ02 020201 0902ｨｺｨｰ060806ｨｬ LacZ ｨｨ 0909020102ｨｪｨｨ02 ｨｨ01 09 06ｨ 05ｨ 09ｨｰｨｹ ｨｮ03ｨｨｨ ｨ 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ ｨｺ08040904, ﾂ02080204 1 ｨｪ0201 0706090502 ｨｬ06010205ｨｨ080609ｨ ｨｪｨｨ07 0706090802030102ｨｪｨｨ07 ｨｪ02 ｨｪｨ ｨ 050601ｨ 05ｨｨ ｨｮ ﾂｨ 09ｨｰｨｨ07 020201 09 ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨｨｨ ｨ ｨｺ0906ｨｪ0609. 0308ｨｨ 05ｨｰ06ｨｬ 06ｨ ｨｪｨ 08ｨｮ0302ｨｪ06 ｨｮ ﾂｨ 09ｨｰｨｨ02 020201 09 06ｨ 08ｨ 040609ｨ ｨｪｨｨｨｨ 0706050401 09ｨｰ08ｨｮｨｺｨｰｨｮ08, 06ｨｺ08ｨｮ03ｨ 06ｨｴｨｨ01 ｨ ｨｺ0906ｨｪ04, ｨｺ06ｨｰ06080402 ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨｨ0806-
130306ｨｰ02ｨｪ02ｨｨｨ 05ｨｹｨｪｨ 07 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 06ｨ 090605ｨ ｨｺｨｨ09ｨ 06ｨｴｨｨ01 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ0401 0005ｨｨ0602ｨｨｨｰ0609 ｭ 7 09ｨ 05ｨｨ09ｨｹ 04ｨ 09 ﾂ02ｨｰ ｨ ｨｮｨｰ060002ｨｪｨｪ0401 0605ｨｨ00060102ｨｪ01080602ｨｨｨｰ0609 0706090802030102ｨｪｨｪ060006 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ. 00020301ｨｮ 09ｨｪｨｮｨｰ0802ｨｪｨｪ02ｨｦ 070609020801ｨｪ0609ｨｰｨｹ06 ｨｬ02 ﾂ02ｨｪ0401 020201 ｨｨ ｨｪ02ｨｦ08060502ｨｬｨｬ0602ｨｨｨｰｨ ｨｬｨｨ 0609ｨｰｨ 09ｨ 050609ｨｹ 090906ｨ 0601ｨｪ0602 07080609ｨｰ08ｨ ｨｪ09ｨｰ0906 ｨｨ 06ｨｰ09ｨｮｨｰ09ｨｰ090609ｨ 05ｨｨ ｨｺ0502ｨｰ06 ﾂｨｪ0402 ｨｺ06ｨｪｨｰｨ ｨｺｨｰ04. 0306 01ｨ ｨｪｨｪ04ｨｬ T. Takami ｨｨ 0906ｨ 09ｨｰ06080609 [36], ｨｪｨ ｨｨｨ 06050202 05000002ｨｺｨｰｨｨ09ｨｪ04ｨｬｨｨ 09 06ｨｰｨｪ060302ｨｪｨｨｨｨ 0802ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨｨｨ ｨ ｨｺ0906ｨｪ0609 09 0406ｨｪ02 ｨｮ03ｨｨｨ ｨ 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ 0709050706ｨｰ0907 ｨｺ0502ｨｰｨｺｨｨ 0605ｨｨ00060102ｨｪ0108060005ｨｨｨｨ, 0601ｨｪｨ ｨｺ06 ｨ ｨｰｨｰ08ｨ ｨｺ02ｨｨ07 ｨｪ02ｨｦ08ｨｨｨｰ0609 09 0406ｨｪｨｮ 0706090802030102ｨｪｨｨ07 0609ｨｮｨｴ0209ｨｰ09050702ｨｰ0907 ｨ 05ｨ 000601ｨ 0807 020201. 00 09090704ｨｨ 09 05ｨｰｨｨｨｬ 0708020105060302ｨｪ06 ｨｨ09070605ｨｹ040609ｨ ｨｰｨｹ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ06 ｨｺ0502ｨｰ06ｨｺ 0605ｨｨ00060102ｨｪ0108060005ｨｨｨｨ 09 06 ﾂｨ 00 ｨｮ03ｨｨｨ ｨ, ｨ 020201 ｪ 09 0708ｨｨ050203ｨ ｨｴｨｨ02 ｨｰｨｺｨ ｨｪｨｨ 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ. 08ｨ ｨｺ 0601ｨｨｨｪ ｨｨ04 09ｨ 08ｨｨｨ ｨｪｨｰ0609 ｨｰ08ｨ ｨｺｨｰ0609ｨｺｨｨ 070605ｨｮ ﾂ02ｨｪｨｪ0401 00ｨ ｨｺｨｰ0609, 09050201ｨｮ02ｨｰ 0708ｨｨ090209ｨｰｨｨ ｨｰ06 ﾂｨｺｨｮ 040802ｨｪｨｨ07 Y. Li ｨｨ 0906ｨ 09ｨｰ06080609 [18], ｨｺ06ｨｰ06080402 0708ｨｨ ｨｨ04ｨｮ ﾂ02ｨｪｨｨｨｨ 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ 020201 0706090502 0601ｨｪ0609ｨｰ060806ｨｪｨｪ02ｨｦ 07020802080204ｨｺｨｨ ｨｺ0608ｨｰｨｨｨｺ060907ｨｨｨｪｨ 05ｨｹｨｪ060006 ｨｰ08ｨ ｨｺｨｰｨ ｨｺ08040904 ｨｮ09ｨｰｨ ｨｪ0609ｨｨ05ｨｨ, ﾂｨｰ06 ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨ 02ｨｨ07 ｨ ｨｺ0906ｨｪ0609 0609ｨｮｨｴ0209ｨｰ09050705ｨ 09ｨｹ 04ｨ 09 ﾂ02ｨｰ ｨｪ02ｨｦ08060502ｨｬｨｬ0602ｨｨｨｰ0607060106ｨ ｨｪ0401 020201, ｨｰ060001ｨ ｨｺｨ ｨｺ ｨ 09ｨｰ080602ｨｨｨｰ0607060106ｨ ｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ ｨｨ04 ｨｺｨｮ05ｨｹｨｰｨｮ0804 020201 000608ｨｬｨｨ080609ｨ 05ｨｨ 06ｨ ｨｴｨｨ02 ｨｪｨ 0708ｨ 09050706ｨｴｨｨ02 ｨｰ06ｨｪｨｪ0205ｨｨ 010507 07ｨｮ ﾂｨｺ0609 08020002ｨｪ0208ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｪ02ｨｦ08ｨｨｨｰ0609. 06ｨｰ06 04ｨ ｨｺ0506 ﾂ02ｨｪｨｨ02 09060005ｨ 09ｨｮ02ｨｰ0907 09 0708020109ｨｰｨ 090502ｨｪｨｨ07ｨｬｨｨ 06 0002ｨｪ06ｨｰｨｨ07ｨｨ ﾂ0209ｨｺ06ｨｦ 08ｨ 04ｨｪ06080601ｨｪ0609ｨｰｨｨ 020201 09 ｨｮ09050609ｨｨ0701 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07. 0201ｨｪｨ ｨｺ06, J.G. Boyd ｨｨ 0906ｨ 09ｨｰ060804 [3] ｨｮ09ｨｰｨ ｨｪ0609ｨｨ05ｨｨ, ﾂｨｰ06 020201, 09 06ｨｰ05ｨｨ ﾂｨｨ02 06ｨｰ ｨｺ0502ｨｰ06ｨｺ 0605ｨｨ00060102ｨｪ0108060005ｨｨｨｨ, in vitro ｨｨ in vivo 05ｨｺ090708020909ｨｨ08ｨｮ06ｨｰ ｨ ｨｺｨｰｨｨｨｪ090907040409ｨ 06ｨｴｨｨｨｦ ｨ 020506ｨｺ ｨｺｨ 05ｨｹ0706ｨｪｨｨｨｪ. 0308ｨｨ 05ｨｰ06ｨｬ 0706090502 ｨｨｨｪｨｰ08ｨ 0907ｨｨｨｪｨ 05ｨｹｨｪ06ｨｦ ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ｨｪ02 ｨｪｨ ｨ 050601ｨ 05ｨｨ ｨｰ08ｨ ｨｪ09000608ｨｬｨ 02ｨｨｨｨ ｨｺｨ 05ｨｹ0706ｨｪｨｨｨｪ0706050603ｨｨｨｰ0205ｨｹｨｪ0401 020201 09 ｨｰｨ ｨｺ ｨｪｨ 040409ｨ 02ｨｬ0402 ｨｪ02ｨｦ08060502ｨｬｨｬ0602ｨｨｨｰ0607060106ｨ ｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ 09 09060108ｨ ｨｪ02ｨｪｨｨ02ｨｬ 0708ｨｨ09ｨｮｨｴｨｨ01 ｨｨｨｬ ｨｬ06080006050600ｨｨ ﾂ0209ｨｺｨｨ01 ｨｨ ｨｪ02ｨｦ080601ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨ01 090906ｨｦ09ｨｰ09. 000201ｨ ｨｪｨｨ04ｨｬ04 ｨ ｨｰｨｰ08ｨ ｨｺ02ｨｨｨｨ ｨ ｨｺ0906ｨｪｨ 05ｨｹｨｪ0401 ｨｺ06ｨｪｨｮ090609 080609ｨｰｨ 0708ｨｨ ｨｮ ﾂｨ 09ｨｰｨｨｨｨ 020201. 0308ｨｨ ﾂｨｨｨｪ04 0706050603ｨｨｨｰ0205ｨｹｨｪ060006 0905ｨｨ07ｨｪｨｨ07 020201 ｨｪｨ 08020002ｨｪ0208ｨｨ08ｨｮ06ｨｴｨｨｨｦ ｨ ｨｺ0906ｨｪ ｨｪ02 ｨｨ04ｨｮ ﾂ02ｨｪ04. 03080201070605ｨ 00ｨ 06ｨｰ, ﾂｨｰ06 020201 000608ｨｬｨｨ08ｨｮ06ｨｰ ｨｰｨｮｨ ｨｮ050607060106ｨ ｨｪ0402 09ｨｰ08ｨｮｨｺｨｰｨｮ0804 ｨｨ ｨ 05ｨ 000601ｨ 0807 05ｨｺ090708020909ｨｨｨｨ ｨ 01000204ｨｨｨｪ0609, 0902ｨｺ080202ｨｨｨｨ 00ｨ ｨｺｨｰ06080609 080609ｨｰｨ ｨｨ ｨ 0205ｨｺ0609 ｨｰｨｺｨ ｨｪ0209060006 ｨｬｨ ｨｰ08ｨｨｨｺ09ｨ 0902ｨｺｨｰ0608ｨｨ04ｨｨ08ｨｮ06ｨｰ 07020802ｨｬ02ｨｴ02ｨｪｨｨ02 ｨ ｨｺ0906ｨｪｨ 05ｨｹｨｪ0401 ｨｺ06ｨｪｨｮ090609, ﾂｨｰ06 06ｨ 050200 ﾂｨ 02ｨｰ 0908ｨ 09ｨｰｨ ｨｪｨｨ02 ｨｪ02ｨｦ08ｨｨｨｰ0609 09 0406ｨｪｨｮ 0706090802030102ｨｪｨｨ07 ｨｨ 01ｨｨ09ｨｰｨ 05ｨｹｨｪ0402 ｨｺ ｨｪ02ｨｬｨｮ ｨｮ ﾂｨ 09ｨｰｨｺｨｨ 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ. 06ｨ ｨｺ, 020201 ｨｬ0502ｨｺ0607ｨｨｨｰｨ 06ｨｴｨｨ01 in vitro 05ｨｺ090708020909ｨｨ08ｨｮ06ｨｰ PSA-NCAM ｨｨ NCAM, in vivo ｨｨ in vitro 05ｨｺ090708020909ｨｨ08ｨｮ06ｨｰ L1, 05ｨ ｨｬｨｨｨｪｨｨｨｪ ｨｨ 0108ｨｮ00ｨｨ02 ｨ 0205ｨｺｨｨ 09ｨｪ02ｨｺ0502ｨｰ06 ﾂｨｪ060006 ｨｬｨ ｨｰ08ｨｨｨｺ09ｨ, 06ｨ 05ｨ 01ｨ 06ｨｴｨｨ02 090408ｨ 0302ｨｪｨｪ04ｨｬ ｨｪ02ｨｦ08ｨｨｨｰ060002ｨｪｨｪ04ｨｬ 0102ｨｦ09ｨｰ09ｨｨ02ｨｬ [6, 11, 30, 31]. 020201 0902ｨｺ0802ｨｰｨｨ08ｨｮ06ｨｰ NGF, BDNF, GDNF ｨｨ CNTF; 05ｨｺ090708020909ｨｨ08ｨｮ06ｨｰ ｨｺｨｨ090504ｨｦ ｨｨ 0609ｨｪ0609ｨｪ06ｨｦ FGF, TGFｦﾁ, IGF-I, IGF-II, PDGFｦﾁ, PDGFｦﾂ, ｨｪ02ｨｦ0806070207ｨｰｨｨ01 Y, ｨｪ02ｨｺ09ｨｨｨｪ 0005ｨｨｨ 05ｨｹｨｪ060006 070806ｨｨ090106030102ｨｪｨｨ07, trkb, neurturin, 0802020207ｨｰ060804 GFRｦﾁ1 ｨｨ GFRｦﾁ2, ｨｪ06 ｨｪ02 05ｨｺ090708020909ｨｨ08ｨｮ06ｨｰ Ret, ｨ 0204 ｨｺ06ｨｰ0608060006 09ｨｨ00ｨｪｨ 05ｨｹｨｪｨ 07 ｨｰ08ｨ ｨｪ0901ｨｮｨｺ02ｨｨ07 ﾂ02080204 05ｨｰｨｨ 0802020207ｨｰ060804 ｨｪ02090604ｨｬ0603ｨｪｨ [4, 23, 32, 37]. 01ｨ ｨｺ06ｨｪ0202, 020201 in vivo 05ｨｺ090708020909ｨｨ08ｨｮ06ｨｰ 00ｨ 0502ｨｺｨｰｨｨｨｪ-3, ｨｺ06ｨｰ060804ｨｦ 0708ｨｨｨｪｨｨｨｬｨ 02ｨｰ ｨｮ ﾂｨ 09ｨｰｨｨ02 0906 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨｨｨ 05ｨｰｨｨ01 ｨｺ0502ｨｰ06ｨｺ 09 ｨ ｨｺ0906ｨｪｨ ｨｬｨｨ 0902ｨｪ090608ｨｪ0401 ｨｪ02ｨｦ0806ｨｪ0609 [35]. 08ｨｪｨ 05ｨｨ04 0708ｨｨ09020102ｨｪｨｪ0401 01ｨ ｨｪｨｪ0401 05ｨｨｨｰ0208ｨ ｨｰｨｮ0804 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ02ｨｰ, ﾂｨｰ06 020201 ｨｺｨ ｨｺ 060906ｨ 04ｨｦ ｨｬ0608000600ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ04ｨｦ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰ 070208ｨｨ000208ｨｨ ﾂ0209ｨｺ060006 06ｨｰ010205ｨ 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ060006 ｨ ｨｪｨ 05ｨｨ04ｨ ｨｰ0608ｨ ｨｬ0600ｨｮｨｰ ｨ 04ｨｰｨｹ 05000002ｨｺｨｰｨｨ09ｨｪ06 ｨｨ09070605ｨｹ040609ｨ ｨｪ04 010507 ｨｪ02ｨｦ0806ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨｨｨ 0708ｨｨ ｨｰ08ｨ 09ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｬ 0706090802030102ｨｪｨｨｨｨ 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ ｨｨ 070208ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ0208090609, ｨ ｨｰｨ ｨｺ0302 0708ｨｨ 0102ｨｬｨｨ0205ｨｨｨｪｨｨ04ｨｨ08ｨｮ06ｨｴｨｨ01 07080602020909ｨ 01. 0201ｨｪｨ ｨｺ06, ｨｪ0209ｨｬ06ｨｰ0807 ｨｪｨ ｨｪｨ ｨｺ06070502ｨｪｨｪ04ｨｦ ｨ 0605ｨｹ0306ｨｦ 05ｨｺ09070208ｨｨｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ04ｨｦ ｨｬｨ ｨｰ0208ｨｨｨ 05 09 01ｨ ｨｪｨｪ06ｨｬ ｨｪｨ 0708ｨ 090502ｨｪｨｨｨｨ, ｨｬｨｪ0600ｨｨ02 09060708060904 ｨｬ02ｨｰ0601ｨｨ ﾂ0209ｨｺ060006 01ｨ 08ｨ ｨｺｨｰ0208ｨ ｨｪ020709ｨｪ04 ｨｨ ｨｰ0802ｨ ｨｮ06ｨｰ 07080609020102ｨｪｨｨ07 01ｨ 05ｨｹｨｪ02ｨｦ03ｨｨ01 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ. 010206ｨ 010601ｨｨｨｬ06 ｨｮ0005ｨｮｨ 0502ｨｪｨｪ0602 ｨｨ04ｨｮ ﾂ02ｨｪｨｨ02 0706ｨｰ02ｨｪ02ｨｨｨ 05ｨｹｨｪ0401 090604ｨｬ0603ｨｪ0609ｨｰ02ｨｦ 020201, 09 ﾂｨ 09ｨｰｨｪ0609ｨｰｨｨ, ｨｨ01 07080605ｨｨ000208ｨ ｨｰｨｨ09ｨｪ060006 ｨｨ 01ｨｨ0000020802ｨｪ02ｨｨ08060906 ﾂｨｪ060006 0706ｨｰ02ｨｪ02ｨｨｨ 05ｨ 09 ｨｮ09050609ｨｨ01 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07. 060802ｨ ｨｮ06ｨｰ 0106070605ｨｪｨｨｨｰ0205ｨｹｨｪ06ｨｦ 08ｨ 0408ｨ ｨ 06ｨｰｨｺｨｨ ｨｬ02ｨｰ060104 01ｨｨ0000020802ｨｪ02ｨｨｨ 05ｨｹｨｪ060006 08ｨ 0401020502ｨｪｨｨ07 0002ｨｪ06ｨｰｨｨ07ｨｨ ﾂ0209ｨｺｨｨ01 09ｨ 08ｨｨｨ ｨｪｨｰ0609 ｨｺ0502ｨｰ06ｨｺ 09 ｨｺｨｮ05ｨｹｨｰｨｮ08ｨ 01 020201 09 070609050201ｨｮ06ｨｴｨｨｨｬ ｨｨ04ｨｮ ﾂ02ｨｪｨｨ02ｨｬ ｨｨ01 0706ｨｰ02ｨｪ02ｨｨｨ 05ｨｹｨｪ0401 090906ｨｦ09ｨｰ09 ｨｨ 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨ07 09 ｨｺｨ ﾂ0209ｨｰ0902 ｨｺ0502ｨｰ06 ﾂｨｪ060006 ｨｬｨ ｨｰ0208ｨｨｨ 05ｨ 010507 09060909ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ 0708ｨｨ 0706090802030102ｨｪｨｨｨｨ 0907ｨｨｨｪｨｪ060006 ｨｬ060400ｨ. 010206ｨ 010601ｨｨｨｬｨ ｨｰｨ ｨｺ0302 05ｨｺ09070208ｨｨｨｬ02ｨｪｨｰｨ 05ｨｹｨｪｨ 07 ｨ 070806ｨ ｨ 02ｨｨ07 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 08ｨ 0405ｨｨ ﾂｨｪ0401 09ｨｨ010609 070605ｨｨｨｬ0208ｨｪ0401 ｨｪ0609ｨｨｨｰ020502ｨｦ 010507 ｨｺ0502ｨｰ06 ﾂｨｪ0401 09ｨｮ090702ｨｪ04ｨｨｨｦ 020201 09 07ｨ ｨｰ06ｨｬ06080006050600ｨｨ ﾂ0209ｨｺｨｨｨｬ ｨｨ04ｨｮ ﾂ02ｨｪｨｨ02ｨｬ 0802ｨ ｨｺ02ｨｨｨｨ 06ｨｺ08ｨｮ03ｨ 06ｨｴ020006 0902ｨｴ0209ｨｰ09ｨ ｨｬ060400ｨ ｨｪｨ ｨｨｨｬ0705ｨ ｨｪｨｰｨ 02ｨｨ06 ｨｨ09ｨｺｨｮ0909ｨｰ0902ｨｪｨｪ0401 ｨｬｨ ｨｰ0208ｨｨｨ 050609. 04020302ｨｪｨｨ02 05ｨｰｨｨ01 0906070806090609 ｨｨｨｬ0202ｨｰ 09ｨ 03ｨｪ0602 0708ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺ0602 04ｨｪｨ ﾂ02ｨｪｨｨ02 010507 08ｨ 0408ｨ ｨ 06ｨｰｨｺｨｨ ｨｨ 09060902080302ｨｪ09ｨｰ090609ｨ ｨｪｨｨ07 08ｨ 02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｬ02ｨｰ06010609 ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨ07 020201 09 ｨｪ02ｨｦ0806ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰ06050600ｨｨｨｨ. 0507ｨｨ0906ｨｺ 05ｨｨｨｰ0208ｨ ｨｰｨｮ0804 1. 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