ANTENATAL EXPOSURE FOLLOWING THE CHERNOBYL ACCIDENT: NEUROPSYCHIATRIC ASPECTS 08010603010806080905010203 02090907 ﾁ03010603 00050903020506000603 080008040606 0108 ﾁ030401020904090505080207 080605: 0103070402030506090608060406 ﾁ0305080603 08050303080604 S.A. Igumnov 1, V.V. Drozdovitch 2 1 Belarusian State Pedagogical University,Department of Psychology,Minsk,Belarus 2 Joint Institute of Power and Nuclear Research - "Sosny",Branch "Institute of Power Engineering Problems", Minsk, Republic of Belarus 05.08. 0600ｨｮｨｬｨｪ0609 1, 00.00. 02080604010609ｨｨ ﾂ 2 1 0902050608ｨｮ0909ｨｺｨｨｨｦ 000609ｨｮ01ｨ 0809ｨｰ0902ｨｪｨｪ04ｨｦ 070201ｨ 000600ｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｮｨｪｨｨ09020809ｨｨｨｰ02ｨｰ,ｨｺｨ 00020108ｨ 0709ｨｨ0106050600ｨｨｨｨ,00ｨｨｨｪ09ｨｺ,090205ｨ 08ｨｮ09ｨｹ 2 02ｨ ｨｲ0201ｨｨｨｪ02ｨｪｨｪ04ｨｦ ｨｨｨｪ09ｨｰｨｨｨｰｨｮｨｰ 05ｨｪ02080002ｨｰｨｨ ﾂ0209ｨｺｨｨ01 ｨｨ 07010208ｨｪ0401 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ - "050609ｨｪ04", 06ｨｰ01020502ｨｪｨｨ02 "06ｨｪ09ｨｰｨｨｨｰｨｮｨｰ 070806ｨ 0502ｨｬ 05ｨｪ02080002ｨｰｨｨｨｺｨｨ", 00ｨｨｨｪ09ｨｺ, 04020907ｨｮｨ 05ｨｨｨｺｨ 090205ｨ 08ｨｮ09ｨｹ Abstract Ten years follow-up investigation of intellectual development of 250 persons from Belarus exposed in utero following the Chernobyl accident and a control group of 250 persons from non- and slightly contaminated regions has been conducted. Neuropsychiatry and psychological examinations were performed among persons of both groups at the age of 6-7, 10-12, and 15-16 years. Mean antenatal internal dose to thyroid arising from the intake of 131I among persons of exposed group is 390 ﾀ550 mgy (maximal dose - 4100 mgy), in control group - 35 ﾀ65 mgy. Mean antenatal external dose among persons of exposed group is 10 ﾀ13 mgy,maximal dose - 91 mgy. At the age of 6-7 years the persons in the exposed group had a mean Full Scale IQ lower than the control group (89.6 ﾀ10.2 vs 92.1 ﾀ10.5,p=0.007). At the age of 10-12 years there was no statistically significant difference between the two groups (94.3 ﾀ10.4 vs 95.8 ﾀ10.9,p=0.117). Positive dynamics of intellectual development in persons of both groups has been observed up to age of 15-16 years (98.7 ﾀ10.2 ｨｨ 99.5 ﾀ10.5,p=0.171). No statistically significant correlation was found in exposed group between individual thyroid dose as well as individual antenatal external dose and IQ at the different ages. In both groups we notice a positive moderate correlation between IQ of persons and the educational level of their parents. We conclude that probably a significant role in the genesis of borderline intellectual functioning and emotional disorders in the exposed group of persons was played by unfavorable social-psychological and social-cultural factors. Keywords: Chernobyl accident, exposure in utero, intellectual development, borderline intellectual functioning,emotional disorders INTRODUCTION 0000030203010603 Antenatal exposure of the thyroid gland to ionizing radiation is one of the factors that might unfavorably influence on the intellectual development. Radiation affecting of the thyroid gland leads to involvement of other endocrine glands in the pathological process through the thyroid-hypophysis-hypothalamus system (Lyaginskaya A.M. et al.,1992). Among the unfavorable psychosocial factors capable to affect the mental health of children there are to be taken into account the effects of forced relocation or adaptation to new conditions of living in areas exposed after the contamination. These factors lead to psycho-emotional stress in parents,and affected family relations (Kolominsky Ya.I., Igumnov S.A., 1995). Thus in estimating the influence of the Chernobyl nuclear power plant accident on the psychological development of persons,it is necessary to take into account both ante- and postnatal irradiation,nonradiation burdening exogenous and psychosocial factors (Nyagu A.I. et al., 1996). The present study was concerning the clinical- 08ｨｪｨｰ02ｨｪｨ ｨｰｨ 05ｨｹｨｪ0602 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ02 ｨｴｨｨｨｰ0609ｨｨ01ｨｪ06ｨｦ 030205020404 (0204) 0709050702ｨｰ0907 00ｨ ｨｺｨｰ060806ｨｬ, 0907060906ｨ ｨｪ04ｨｬ 06ｨｺｨ 04ｨ ｨｰｨｹ ｨｪ0200ｨ ｨｰｨｨ09ｨｪ0602 0905ｨｨ07ｨｪｨｨ02 ｨｪｨ ｨｨｨｪｨｰ02050502ｨｺｨｰｨｮｨ 05ｨｹｨｪ0602 08ｨ 0409ｨｨｨｰｨｨ02. 0006040102ｨｦ09ｨｰ09ｨｨ02 ｨｪｨ 0204 08ｨ 01ｨｨ06ｨｨ0406ｨｰ06070609 ｨｦ0601ｨ ｨｬ060302ｨｰ 0709ｨｨｨｰｨｹ0907 ｨｪｨ ﾂｨ 05ｨｹｨｪ04ｨｬ 040902ｨｪ06ｨｬ 0906090502 ﾂ02ｨｪｨｨ07 09 07ｨ ｨｰ06050600ｨｨ- ﾂ0209ｨｺｨｨｨｦ 07080602020909 ｨｨ 0108ｨｮ00ｨｨ01 05ｨｪ0106ｨｺ08ｨｨｨｪｨｪ0401 0302050204 ﾂ02080204 09ｨｨ09ｨｰ02ｨｬｨｮ 0204-00ｨｨ070600ｨｨ04-00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ09 (090700ｨｨｨｪ09ｨｺｨ 07 08.00. ｨｨ 0906ｨ 09ｨｰ.,1992). 05080201ｨｨ ｨｪ02ｨ 05ｨ 00060708ｨｨ07ｨｰｨｪ0401 0709ｨｨ0106090602ｨｨｨ 05ｨｹｨｪ0401 00ｨ ｨｺｨｰ06080609, 0907060906ｨ ｨｪ0401 06ｨｺｨ 04ｨ ｨｰｨｹ 0905ｨｨ07ｨｪｨｨ02 ｨｪｨ 0709ｨｨ01ｨｨ ﾂ0209ｨｺ0602 040106080609ｨｹ02 0102ｨｰ02ｨｦ, ｨｪ0205ｨｹ0407 ｨｪ02 ｨｮ ﾂｨｨｨｰ0409ｨ ｨｰｨｹ 05000002ｨｺｨｰ04 0904ｨｪｨｮ030102ｨｪｨｪ06ｨｦ ｨｬｨｨ0008ｨ 02ｨｨｨｨ ｨｨ05ｨｨ 0708ｨｨ0907060906ｨ 0502ｨｪｨｨ07 ｨｺ ｨｪ060904ｨｬ ｨｮ09050609ｨｨ07ｨｬ 03ｨｨ04ｨｪｨｨ ｨｪｨ 070609ｨｰ08ｨ 01ｨ 0903ｨｨ01 ｨｰ020808ｨｨｨｰ0608ｨｨ0701. 06ｨｰｨｨ 00ｨ ｨｺｨｰ060804 0708ｨｨ09060107ｨｰ ｨｺ 0709ｨｨ010605ｨｬ0602ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｬｨｮ 09ｨｰ08020909ｨｮ ｨｮ 080601ｨｨｨｰ020502ｨｦ ｨｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨ06 0902ｨｬ02ｨｦｨｪ0401 0904ｨ ｨｨｨｬ0606ｨｰｨｪ060302ｨｪｨｨｨｦ (08060506ｨｬｨｨｨｪ09ｨｺｨｨｨｦ 08.09.,0600ｨｮｨｬｨｪ0609 05.08.,1995). 0308ｨｨ 060202ｨｪｨｺ02 0905ｨｨ07ｨｪｨｨ07 ﾁ0208ｨｪ06ｨ 0405ｨｹ09ｨｺ06ｨｦ ｨ 09ｨ 08ｨｨｨｨ ｨｪｨ 0709ｨｨ0106050600ｨｨ ﾂ0209ｨｺ0602 08ｨ 0409ｨｨｨｰｨｨ02 05ｨｨ02, 0706010902080003ｨｨ010907 0906040102ｨｦ09ｨｰ09ｨｨ06 09 ｨ ｨｪｨｰ02ｨｪｨ ｨｰｨ 05ｨｹｨｪ06ｨｬ 070208ｨｨ060102, ｨｪ0206ｨ 010601ｨｨｨｬ06 ｨｮ ﾂｨｨｨｰ0409ｨ ｨｰｨｹ ｨｪ02 ｨｰ0605ｨｹｨｺ06 ｨ ｨｪｨｰ02ｨｪｨ ｨｰｨ 05ｨｹｨｪ0602 ｨｨ 070609ｨｰｨｪｨ ｨｰｨ 05ｨｹｨｪ0602 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ02 ｨｨ ｨｪ0208ｨ 01ｨｨｨ 02ｨｨ06ｨｪｨｪ0402 06ｨｰ070006ｨｴｨ 06ｨｴｨｨ02 00ｨ ｨｺｨｰ060804, ｨｪ06 ｨｨ 0709ｨｨ0106090602ｨｨｨ 05ｨｹｨｪ0402 00ｨ ｨｺｨｰ060804 (010700ｨｮ 08.06. ｨｨ 0906ｨ 09ｨｰ.,1996). 108
13psychological estimation if intellectual progress in children exposed to antenatal exposure to ionizing radiation after the Chernobyl NPP accident. Reconstruction of individual radiation doses of antenatal exposure on thyroid and whole body external irradiation was held under study conduction with application within further clinicaldosimetry analysis. Igumnov, Drozdovitch / International Journal of Radiation Medicine 2004, 6(1-4): 108-115 01ｨ 09ｨｰ0607ｨｴ0202 ｨｨ09090502010609ｨ ｨｪｨｨ02 0706090907ｨｴ02ｨｪ06 ｨｺ05ｨｨｨｪｨｨｨｺ06-0709ｨｨ0106050600ｨｨ ﾂ0209ｨｺ06ｨｦ 060202ｨｪｨｺ02 ｨｨｨｪｨｰ02050502ｨｺｨｰｨｮｨ 05ｨｹｨｪ060006 08ｨ 0409ｨｨｨｰｨｨ07 0102ｨｰ02ｨｦ,0706010902080003ｨｨ010907 ｨ ｨｪｨｰ02ｨｪｨ ｨｰｨ 05ｨｹｨｪ06ｨｬｨｮ 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ06 090905020109ｨｰ09ｨｨ02 ｨ 09ｨ 08ｨｨｨｨ ｨｪｨ ﾁ0208ｨｪ06ｨ 0405ｨｹ09ｨｺ06ｨｦ 080605. 00 01060102 ｨｨ09090502010609ｨ ｨｪｨｨ07 0609ｨｮｨｴ0209ｨｰ090502ｨｪｨ 0802ｨｺ06ｨｪ09ｨｰ08ｨｮｨｺ02ｨｨ07 ｨｨｨｪ01ｨｨ09ｨｨ01ｨｮｨ 05ｨｹｨｪ0401 010604 ｨ ｨｪｨｰ02ｨｪｨ ｨｰｨ 05ｨｹｨｪ060006 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 0204 ｨｨ ｨ ｨｪｨｰ02ｨｪｨ ｨｰｨ 05ｨｹｨｪ060006 09ｨｪ0203ｨｪ020006 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07,ｨｺ06ｨｰ06080402 ｨ 0405ｨｨ ｨｨ09070605ｨｹ040609ｨ ｨｪ04 09 01060102 ｨｺ05ｨｨｨｪｨｨｨｺ06-010604ｨｨｨｬ02ｨｰ08ｨｨ ﾂ0209ｨｺ060006 ｨ ｨｪｨ 05ｨｨ04ｨ. OBJECTIVE OF THE STUDY * prospective investigation of the intellectual development at the age of 6-7 years till age 15-16 years among persons exposed in utero following the Chernobyl accident; * comparative analysis of the data obtained as a result of the clinical and psychological investigation and dosimetry data; * investigation of the role of unfavorable socialpsychological and social-cultural factors stipulated by the Chernobyl accident and its consequences in the genesis of the disturbances of intellectual development of exposed children. MATERIALS AND METHODS Participants 05080208 ﾁ06 060505090302020008010608 * 070806090702ｨｺｨｰｨｨ09ｨｪ0602 ｨｨ09090502010609ｨ ｨｪｨｨ02 ｨｨｨｪｨｰ02050502ｨｺｨｰｨｮｨ 05ｨｹｨｪ060006 08ｨ 0409ｨｨｨｰｨｨ07 05ｨｨ02, 0706010902080003ｨｨ010907 ｨ ｨｪｨｰ02ｨｪｨ ｨｰｨ 05ｨｹｨｪ06ｨｬｨｮ 06ｨ 05ｨｮ- ﾂ02ｨｪｨｨ06 09 080204ｨｮ05ｨｹｨｰｨ ｨｰ02 ｨ 09ｨ 08ｨｨｨｨ ｨｪｨ ﾁ0208ｨｪ06ｨ 0405ｨｹ09ｨｺ06ｨｦ 080605, 09 09060408ｨ 09ｨｰ02 06ｨｰ 6-7 0106 15-16 0502ｨｰ; * 0908ｨ 09ｨｪｨｨｨｰ0205ｨｹｨｪ04ｨｦ ｨ ｨｪｨ 05ｨｨ04 01ｨ ｨｪｨｪ0401, 070605ｨｮ ﾂ02ｨｪｨｪ0401 09 01060102 ｨｺ05ｨｨｨｪｨｨｨｺ06-0709ｨｨ0106050600ｨｨ ﾂ0209ｨｺ060006 ｨｨ09090502010609ｨ ｨｪｨｨ07, ｨｨ 010604ｨｨｨｬ02ｨｰ08ｨｨ ﾂ0209ｨｺｨｨ01 01ｨ ｨｪｨｪ0401; * 060202ｨｪｨｺｨ 080605ｨｨ ｨｪ02ｨ 05ｨ 00060708ｨｨ07ｨｰｨｪ0401 0709ｨｨ0106050600ｨｨ ﾂ0209ｨｺｨｨ01 ｨｨ 090602ｨｨｨ 05ｨｹｨｪ06-0102ｨｬ060008ｨ 00ｨｨ ﾂ0209ｨｺｨｨ01 00ｨ ｨｺｨｰ06080609, 06ｨ ｨｮ090506090502ｨｪｨｪ0401 ﾁ0208ｨｪ06ｨ 0405ｨｹ09ｨｺ06ｨｦ ｨ 09ｨ 08ｨｨ02ｨｦ ｨｨ 0202 07060905020109ｨｰ09ｨｨ07ｨｬｨｨ, 09 070806ｨｨ090106030102ｨｪｨｨｨｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ ｨｨｨｪｨｰ02050502ｨｺｨｰｨｮｨ 05ｨｹｨｪ060006 08ｨ 0409ｨｨｨｰｨｨ07 ｨｮ 06ｨ 05ｨｮ ﾂ02ｨｪｨｪ0401 0102ｨｰ02ｨｦ. 000806030406080904 06 000306020204 07 ﾂｨ 09ｨｰｨｪｨｨｨｺｨｨ ｨｨ09090502010609ｨ ｨｪｨｨ07 The exposed group was of 250 persons, born between May 1986 and February 1987. During the Chernobyl accident their pregnant mothers lived in the highly contaminated settlements where 137 Cs soil deposition densities ranged from 555 to 18,500 kbq m -2. The control group was formed by random selection and consisted of 250 persons had been born between May 1986 and February 1987. Their mothers had constantly lived in settlements with low and mild contamination (from 2 to 200 kbq m -2 of 137 Cs). The distribution of persons according to sex and the period of gestation at the time of the Chernobyl accident is given in table 1. Also there were no relevant distinctions of social status of parents of persons belonging to the exposed and control group. 02ｨ 05ｨｮ ﾂ02ｨｪｨｪｨ 07 0008ｨｮ0707ｨ 090609ｨｰ060705ｨ ｨｨ04 250 05ｨｨ02, 0806030102ｨｪｨｪ0401 09 070208ｨｨ0601 09 ｨｬｨ 07 1986 0706 00020908ｨ 05ｨｹ 1987 000601ｨ 06ｨｰ ｨｬｨ ｨｰ020802ｨｦ, ｨｺ06ｨｰ06080402 ｨｪｨ ｨｬ06ｨｬ02ｨｪｨｰ ｨ 09ｨ 08ｨｨｨｨ ｨｪｨ ﾁ0208ｨｪ06ｨ 0405ｨｹ09ｨｺ06ｨｦ 080605 07080603ｨｨ09ｨ 05ｨｨ ｨｪｨ ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ02ｨｬ0401 ｨｰ020808ｨｨｨｰ0608ｨｨ0701 09 ｨｮ080609ｨｪ02ｨｬ 137 04ｨ 00080704ｨｪ02ｨｪｨｨ07 0706 ﾂ09 Cs 555-18500 ｨｺ09ｨｺ ｨｬ -2. 0806ｨｪｨｰ080605ｨｹｨｪｨ 07 0008ｨｮ0707ｨ ｨ 0405ｨ 09000608ｨｬｨｨ080609ｨ ｨｪｨ ｨｬ02ｨｰ060106ｨｬ 0905ｨｮ ﾂｨ ｨｦｨｪ06ｨｦ 0904ｨ 0608ｨｺｨｨ ｨｨ 090609ｨｰ060705ｨ ｨｨ04 250 0102ｨｰ02ｨｦ, 0806030102ｨｪｨｪ0401 09 070208ｨｨ0601 09 ｨｬｨ 07 1986 0706 00020908ｨ 05ｨｹ 1987 000601ｨ. 0601 ｨｬｨ ｨｰ0208ｨｨ 070609ｨｰ0607ｨｪｨｪ06 07080603ｨｨ09ｨ 05ｨｨ 09 08ｨ ｨｦ06ｨｪｨ 01 09 ｨｪｨｨ04ｨｺｨｨｨｬ ｨｮ080609ｨｪ02ｨｬ 08ｨ 01ｨｨ06ｨ ｨｺｨｰｨｨ09ｨｪ060006 04ｨ 00080704ｨｪ02ｨｪｨｨ07 (2-200 ｨｺ09ｨｺ ｨｬ -2 0706 137 Cs). 04ｨ 0907080201020502ｨｪｨｨ02 0102ｨｰ02ｨｦ 09 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ 070605ｨ ｨｨ 090806ｨｺｨ 000209ｨｰｨ 02ｨｨｨｨ 09 ｨｬ06ｨｬ02ｨｪｨｰ ｨ 09ｨ 08ｨｨｨｨ ｨｪｨ ﾁ0208ｨｪ06ｨ 0405ｨｹ09ｨｺ06ｨｦ 080605 0708020109ｨｰｨ 090502ｨｪ06 09 ｨｰｨ ｨ 05ｨｨ0202 1. 02ｨｰ09ｨｮｨｰ09ｨｰ090609ｨ 05ｨｨ ｨｰｨ ｨｺ0302 010609ｨｰ06090208ｨｪ0402 08ｨ 0405ｨｨ ﾂｨｨ07 09 090602ｨｨｨ 05ｨｹｨｪ06ｨｬ 09ｨｰｨ ｨｰｨｮ0902 080601ｨｨｨｰ020502ｨｦ 0102ｨｰ02ｨｦ 06ｨ 05ｨｮ ﾂ02ｨｪｨｪ06ｨｦ ｨｨ ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ 0008ｨｮ0707. AGE AND SEX DISTRIBUTIONS OF PERSONS OF EXPOSED AND CONTROL GROUPS 04080503040302030903010603 090600 0205010200010207 06 0802010604020905010207 0104070303 0302 0303040602020800 0103050608000606 06 03020907 Gestation Number of persons in Comparison between period, exposed group control group groups, p weeks male female total male female total in gender total 0ｨC7 35 24 59 38 32 70 0.57 0.26 8ｨC15 29 24 53 28 24 52 0.93 0.91 16ｨC25 29 27 56 30 28 58 0.99 0.83 > 25 33 49 82 32 38 70 0.50 0.24 Total 126 124 250 128 122 250 0.86 6ﾓ1 TABLE 1 06080909060008 1 109
Estimation of the period of gestation at the time of the Chernobyl accident was based upon the inferred first day of the last menstrual period and has been calculated with the modified formula of Schull et al. (1988). The mean duration of gestation was assumed as 280 days (assayed since the last menstrual cycle onset). The day of birth was obtained by interview with the mothers of the persons. To obtain the age after fertilization, 14 days have been subtracted from the term of gestation at the time of the Chernobyl accident. 050806ｨｺ 000209ｨｰｨ 02ｨｨｨｨ 09 ｨｬ06ｨｬ02ｨｪｨｰ ﾁ0208ｨｪ06ｨ 0405ｨｹ09ｨｺ06ｨｦ ｨｺｨ ｨｰｨ 09ｨｰ08060004 0904 ﾂｨｨ09050705ｨｨ 0706 ｨｬ0601ｨｨ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ06ｨｦ 000608ｨｬｨｮ0502,0708020105060302ｨｪｨｪ06ｨｦ W. Schull et al. (1989), 07ｨｮｨｰ02ｨｬ 0904 ﾂｨｨｨｰｨ ｨｪｨｨ07 ｨｨ04 280 09ｨｮｨｰ06ｨｺ (09080201ｨｪ0707 07080601060503ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ ｨ 020802ｨｬ02ｨｪｨｪ0609ｨｰｨｨ, ｨｨ04ｨｬ020802ｨｪｨｪｨ 07 0906 01ｨｪ07 ｨｪｨ 09ｨｰｨｮ070502ｨｪｨｨ07 070609050201ｨｪ020006 ｨｬ02ｨｪ09ｨｰ08ｨｮｨ 05ｨｹｨｪ060006 02ｨｨｨｺ05ｨ ) 070208ｨｨ0601ｨ 090802ｨｬ02ｨｪｨｨ ｨｬ020301ｨｮ ｨｬ06ｨｬ02ｨｪｨｰ06ｨｬ ｨｺｨ ｨｰｨ 09ｨｰ08060004 ｨｨ 01ｨ ｨｰ06ｨｦ 0806030102ｨｪｨｨ07 0802ｨ 02ｨｪｨｺｨ. 0604 090806ｨｺｨ ｨ 020802ｨｬ02ｨｪｨｪ0609ｨｰｨｨ 09 ｨｬ06ｨｬ02ｨｪｨｰ ｨ 09ｨ 08ｨｨｨｨ 04ｨ ｨｰ02ｨｬ 0904 ﾂｨｨｨｰｨ 05ｨｨ 14 01ｨｪ02ｨｦ 010507 09ｨｪ020902ｨｪｨｨ07 07060708ｨ 09ｨｺｨｨ ｨｪｨ 090802ｨｬ07 ｨｬ020301ｨｮ ｨｪｨ 09ｨｰｨｮ070502ｨｪｨｨ02ｨｬ 070609050201ｨｪ020006 ｨｬ02ｨｪ09ｨｰ08ｨｮｨ 05ｨｹｨｪ060006 02ｨｨｨｺ05ｨ ｨｨ 0609ｨｮ050702ｨｨ02ｨｦ 09 060705060106ｨｰ09060802ｨｪｨｨ02ｨｬ 07ｨｦ0202ｨｺ0502ｨｰｨｺｨｨ. Dosimetry Thyroid doses from iodine intake were reconstructed on the basis of results of 131 I activity direct measurements in thyroid (if such data were available from measurements held in mothers of children included in the study),or from an 131 I environmental transfer model adapted to the local Belarusian conditions (Drozdovitch V.V. et al., 1997). The regional-specific values were received for the following radio-ecological parameters according to the respective local conditions: (a) ratio between activities of 131 I and 137 Cs in ground deposition; (b) initial interception of 131 I by vegetation; (c) elimination rate of 131 I from grass and milk due to airing and growth; and (d) transfer factor for 131I from grass to cow's milk. Model was validated with the received results validity estimation for 292 settlements where average thyroid radiation doses calculated according to the model were compared to the values of direct 131 I activity measurements in thyroid gland (Gavrilin Yu.I. et al.,1999). For 95% of these settlements the results of the radio-ecological model and the measurements agree within a factor of 2.5 (Drozdovitch V.V.,1999). Thyroid doses for persons exposed in utero were estimated from results of individual thyroid radiation dose estimates for the mother, and from a transfer coefficient from maternal radiation dose to the fetal one with taking into account the period of gestation at the time of exposure (Zvonova I.A., Balonov M.I., 1993). To estimate the individual thyroid doses the following information about the life-style of the mother during the iodine period was obtained by personal interview: (a) consumption rates of fresh milk and diary products; (b) origin of consumed foodstuffs; (c) cessation of consumption of locally produced foodstuffs; (d) place of residence at the time of accident; (e) migration during April-May 1986; (f) stable iodine prophylaxis, etc. Antenatal external doses from radionuclides deposited onto ground were reconstructed also for persons of the exposed and control group. Reconstruction has been performed based on the values of dose rate in uterus per unit of radionuclide deposition density (Jacob P. et al., 1988), radionuclide composition in fallout measured in different 020604ｨｨｨｬ02ｨｰ08ｨｨ07 02060404 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 0204 06ｨｰ 070609ｨｰｨｮ070502ｨｪｨｨ07 ｨｦ0601ｨ ｨ 0405ｨｨ 0802ｨｺ06ｨｪ09ｨｰ08ｨｮｨｨ080609ｨ ｨｪ04 ｨｪｨ 0609ｨｪ060902 080204ｨｮ05ｨｹｨｰｨ ｨｰ0609 070807ｨｬ0401 ｨｨ04ｨｬ020802ｨｪｨｨｨｦ 020006 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 09 0204 (020905ｨｨ 05ｨｰｨｨ ｨｨ04ｨｬ020802ｨｪｨｨ07 ｨ 0405ｨｨ 07080609020102ｨｪ04 010507 ｨｬｨ ｨｰ020802ｨｦ 05ｨｨ02, 09ｨｺ0506 ﾂ02ｨｪｨｪ0401 09 ｨｨ09090502010609ｨ ｨｪｨｨ02) ｨｨ05ｨｨ ｨｨ09070605ｨｹ04ｨｮ07 ｨｬ06010205ｨｹ 07020802ｨｪ0609ｨ 131 I 09 06ｨｺ08ｨｮ03ｨ 06ｨｴ02ｨｦ 0908020102, ｨ 01ｨ 07ｨｰｨｨ080609ｨ ｨｪｨｪｨｮ06 ｨｺ ｨｬ0209ｨｰｨｪ04ｨｬ ｨｮ09050609ｨｨ07ｨｬ (Drozdovitch V.V. et al.,1997). 040200ｨｨ06ｨｪｨ 05ｨｹｨｪ06-09070202ｨｨ00ｨｨ ﾂ0209ｨｺｨｨ02 04ｨｪｨ ﾂ02ｨｪｨｨ07 ｨ 0405ｨｨ 070605ｨｮ ﾂ02ｨｪ04 010507 09050201ｨｮ06ｨｴｨｨ01 08ｨ 01ｨｨ0605ｨｺ06050600ｨｨ ﾂ0209ｨｺｨｨ01 07ｨ 08ｨ ｨｬ02ｨｰ080609 ｨｬ06010205ｨｨ: 1) 06ｨｰｨｪ060302ｨｪｨｨ02 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰ02ｨｦ 131 I ｨｺ 137 Cs 09 090407ｨ 0102ｨｪｨｨ0701; 2) 00ｨ ｨｺｨｰ0608 ｨｪｨ ﾂｨ 05ｨｹｨｪ060006 ｨｮ01020803ｨ ｨｪｨｨ07 131 I 08ｨ 09ｨｰｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ06; 3) 09ｨｺ06080609ｨｰｨｹ 06 ﾂｨｨ09ｨｰｨｺｨｨ 08ｨ 09ｨｰｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ 06ｨｰ 131 I ｨｨ04-04ｨ 070806020209090609 09040902ｨｰ08ｨｨ09ｨ ｨｪｨｨ07 ｨｨ 080609ｨｰｨ ; 4) ｨｺ06050000ｨｨ02ｨｨ02ｨｪｨｰ 07020802010601ｨ 131 I 09 ｨｬ060506ｨｺ06 ｨｺ0608060904. 020507 090208ｨｨ00ｨｨｨｺｨ 02ｨｨｨｨ ｨｬ06010205ｨｨ ｨｨ 060202ｨｪｨｺｨｨ 010609ｨｰ06090208ｨｪ0609ｨｰｨｨ 070605ｨｮ ﾂｨ 02ｨｬ0401 080204ｨｮ05ｨｹｨｰｨ ｨｰ0609 010507 292 ｨｪｨ 09020502ｨｪｨｪ0401 07ｨｮｨｪｨｺｨｰ0609 07080609020102ｨｪ06 0908ｨ 09ｨｪ02ｨｪｨｨ02 09080201ｨｪｨｨ01 010604 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 0204,08ｨ 0909 ﾂｨｨｨｰｨ ｨｪｨｪ0401 0706 ｨｬ06010205ｨｨ, ｨｨ 060202ｨｪ02ｨｪｨｪ0401 0706 080204ｨｮ05ｨｹｨｰｨ ｨｰｨ ｨｬ 070807ｨｬ0401 ｨｨ04ｨｬ020802ｨｪｨｨｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 131 I 09 0204. (Gavrilin Yu.I. et al., 1999). 020507 95% ｨｪｨ 09020502ｨｪｨｪ0401 07ｨｮｨｪｨｺｨｰ0609 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 08ｨ 09 ﾂ02ｨｰｨ 0706 ｨｬ06010205ｨｨ ｨｨ 0706 070807ｨｬ04ｨｬ ｨｨ04ｨｬ020802ｨｪｨｨ07ｨｬ 09060005ｨ 09ｨｮ06ｨｰ0907 09 070802010205ｨ 01 00ｨ ｨｺｨｰ0608ｨ 2,5 (Drozdovitch, V.V. 1998). 02060404 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 0204 010507 ｨ ｨｪｨｰ02ｨｪｨ ｨｰｨ 05ｨｹｨｪ06 06ｨ 05ｨｮ ﾂ02ｨｪｨｪ0401 05ｨｨ02 060202ｨｪｨｨ09ｨ 05ｨｨ09ｨｹ ｨｪｨ 0609ｨｪ060902 080204ｨｮ05ｨｹｨｰｨ ｨｰ0609 0802ｨｺ06ｨｪ09ｨｰ08ｨｮｨｺ02ｨｨｨｨ ｨｨｨｪ01ｨｨ09ｨｨ01ｨｮｨ 05ｨｹｨｪ0401 010604 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 010507 ｨｬｨ ｨｰ020802ｨｦ ｨｨ ｨｺ06050000ｨｨ02ｨｨ02ｨｪｨｰ0609 07020802010601ｨ 06ｨｰ 01060404 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 0204 ｨｬｨ ｨｰ0208ｨｨ ｨｺ 01060402 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 0204 07050601ｨ 09 ｨｮ ﾂ02ｨｰ06ｨｬ 090806ｨｺｨ ｨ 020802ｨｬ02ｨｪｨｪ0609ｨｰｨｨ 09 ｨｬ06ｨｬ02ｨｪｨｰ 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 (Zvonova I.A., Balonov M.I., 1993). 020202ｨｪｨｺｨｮ ｨｨｨｪ01ｨｨ09ｨｨ01ｨｮｨ 05ｨｹｨｪ0401 010604 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 0204 070806090601ｨｨ05ｨｨ ｨｪｨ 0609ｨｪ0609ｨ ｨｪｨｨｨｨ 01ｨ ｨｪｨｪ0401 06ｨ 08ｨ 04ｨ 03ｨｨ04ｨｪｨｨ ｨｬｨ ｨｰ0208ｨｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 ｨｦ0601ｨｪ060006 070208ｨｨ0601ｨ,070605ｨｮ ﾂ02ｨｪｨｪ06ｨｦ 07ｨｮｨｰ02ｨｬ 0702080906ｨｪｨ 05ｨｹｨｪ0401 06070806090609: 1) ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 0706ｨｰ0802ｨ 050702ｨｬ060006 ｨｬ060506ｨｺｨ ｨｨ ｨｬ060506 ﾂｨｪ0401 07080601ｨｮｨｺｨｰ0609 2) ｨｨ09ｨｰ06 ﾂｨｪｨｨｨｺｨｨ 0706ｨｰ0802ｨ 050702ｨｬ0401 07080601ｨｮｨｺｨｰ0609; 3) 01ｨ ｨｰｨ 070802ｨｺ08ｨ ｨｴ02ｨｪｨｨ07 ｨｮ0706ｨｰ0802ｨ 0502ｨｪｨｨ07 07080601ｨｮｨｺｨｰ0609 07ｨｨｨｰｨ ｨｪｨｨ07 ｨｬ0209ｨｰｨｪ060006 070806ｨｨ0409060109ｨｰ09ｨ ; 4) ｨｬ0209ｨｰ06 03ｨｨｨｰ0205ｨｹ09ｨｰ09ｨ 09 ｨｬ06ｨｬ02ｨｪｨｰ ｨ 09ｨ 08ｨｨｨｨ; 5) 0702080202040104 09 ｨｰ02 ﾂ02ｨｪｨｨ02 ｨ 0708020507-ｨｬｨ 07 1986 00.; 6) ｨｦ0601ｨｪｨ 07 07080600ｨｨ05ｨ ｨｺｨｰｨｨｨｺｨ ｨｨ 0108. 020507 05ｨｨ02 0609ｨｪ0609ｨｪ06ｨｦ ｨｨ ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ 0008ｨｮ0707 ｨ 0405ｨｨ ｨｰｨ ｨｺ0302 0802ｨｺ06ｨｪ09ｨｰ08ｨｮｨｨ080609ｨ ｨｪ04 ｨ ｨｪｨｰ02ｨｪｨ ｨｰｨ 05ｨｹｨｪ0402 01060404 09ｨｪ0203ｨｪ020006 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 06ｨｰ 08ｨ 01ｨｨ06ｨｪｨｮｨｺ05ｨｨ010609, 090407ｨ 0903ｨｨ01 ｨｪｨ 070609020801ｨｪ0609ｨｰｨｹ 0706 ﾂ0904, 09 ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨ02ｨｬ 04ｨｪｨ ﾂ02ｨｪｨｨｨｦ ｨｬ06ｨｴｨｪ0609ｨｰｨｨ 01060404, 0706000506ｨｴ02ｨｪｨｪ06ｨｦ ｨｬｨ ｨｰ0208ｨｨｨｪ09ｨｺ06ｨｦ ｨｬｨ ｨｰｨｺ06ｨｦ,ｨｪｨ 0201ｨｨｨｪｨｨ02ｨｮ 070506ｨｰｨｪ0609ｨｰｨｨ 04ｨ 00080704ｨｪ02ｨｪｨｨ07 (Jacob P. et al.,1988),090606ｨｰｨｪ060302ｨｪｨｨｨｦ 08ｨ 01ｨｨ06ｨｪｨｮｨｺ05ｨｨ010609 09 090407ｨ 0102ｨｪｨｨ0701 09 08ｨ 04ｨｪ0401 080200ｨｨ06-110
13territories, and individual behavior of mothers after the accident. The last one included: (a) residence place at the time of accident; (b) migration within period since the accident till childbirth; (c) type of dwelling; (d) time spent outdoors. Igumnov, Drozdovitch / International Journal of Radiation Medicine 2004, 6(1-4): 108-115 ｨｪｨ 01 ｨｨ 01ｨ ｨｪｨｪ0401 06ｨ 06ｨ 08ｨ 0402 03ｨｨ04ｨｪｨｨ ｨｬｨ ｨｰ0208ｨｨ 0706090502 ｨ 09ｨ 08ｨｨｨｨ: 1) ｨｬ0209ｨｰ06 03ｨｨｨｰ0205ｨｹ09ｨｰ09ｨ 09 ｨｬ06ｨｬ02ｨｪｨｰ ｨ 09ｨ 08ｨｨｨｨ; 2) 0702080202040104 09 ｨｰ02 ﾂ02ｨｪｨｨ02 0706090502ｨ 09ｨ 08ｨｨｨｦｨｪ060006 070208ｨｨ0601ｨ 0106 0806030102ｨｪｨｨ07 0802ｨ 02ｨｪｨｺｨ ; 3) ｨｰｨｨ07 0401ｨ ｨｪｨｨ07, 09 ｨｺ06ｨｰ060806ｨｬ 07080603ｨｨ09ｨ 05ｨ ｨ 020802ｨｬ02ｨｪｨｪｨ 07; 4) 090802ｨｬ02ｨｪｨｨ, 07080609020102ｨｪｨｪ06ｨｬ ｨｪｨ 06ｨｰｨｺ0804ｨｰ06ｨｬ 09060401ｨｮ0102. Psychological examination The intellectual development of these persons was examined by means of psychological testing using the modified Wechsler Intelligence Scale for Children - WISC-III-UK (Wechsler D., 1992). We also applied clinical-psychological and socialpsychological methods: studying of microsocial surrounding of persons and comparative analysis conduction of the education level of their parents (i.e. incomplete secondary,secondary,special secondary and higher education). RESULTS AND DISCUSSION Dosimetry For 64 persons from the exposed group and for 72 persons from the control group a zero thyroid dose from 131 I mother's intake was estimated. It is mainly due to the fact that gestation age of the fetus at the time of the accident was less than 10 weeks and there was no uptake of 131 I by undeveloped thyroid. The mean internal thyroid doses from 131 I were estimated to be 390 ﾀ550 and 35 ﾀ65 mgy in exposed and control group respectively, medians of distributions in both groups - 230 and 14 mgy respectively. In exposed group the maximal individual internal antenatal thyroid dose was 4,100 mgy. The mean doses from external exposure to fetus of 10 ﾀ3 mgy and 0.2 ﾀ0.4 mgy were estimated in exposed and control group, accordingly. Medians of external thyroid dose distribution in exposed and control group were 6 and 0.1 mgy respectively. Among persons of the exposed group the maximal individual external antenatal thyroid dose was 91 mgy. IQ test results At the age 6-7 years persons of the exposed group had a lower mean full-scale Intelligence Quotient (IQ) compared to the control group (89.6 ﾀ10.2 vs. 92.1 ﾀ10.5,p=0.007). We found that persons of the exposed group had a relatively more cases of a low average range of full-scale IQ (IQ=80-89) as compared to the control group (92 persons (36.8%) vs. 66 persons (26.4%) in control group, P=0.012). Clinically the children having low average level of intellectual norm were characterized by moderate disorders of cognitive processes,poor motivation to school education and lack of intellectual prerequisites (active attention, short-term memory, constructional functions, etc.). There were no statistically significant differences between mean IQs 0309ｨｨ0106050600ｨｨ ﾂ0209ｨｺ0602 ｨｨ09090502010609ｨ ｨｪｨｨ02 06ｨｪｨｰ02050502ｨｺｨｰｨｮｨ 05ｨｹｨｪ0602 08ｨ 0409ｨｨｨｰｨｨ02 060202ｨｪｨｨ09ｨ 05ｨｨ 07ｨｮｨｰ02ｨｬ 0709ｨｨ0106050600ｨｨ ﾂ0209ｨｺ060006 ｨｰ0209ｨｰｨｨ080609ｨ ｨｪｨｨ07 0706 ｨ 01ｨ 07ｨｰｨｨ080609ｨ ｨｪｨｪ06ｨｦ 09020809ｨｨｨｨ 01ｨｺｨ 0504 0002ｨｺ09050208ｨ 010507 ｨｨ04ｨｬ020802ｨｪｨｨ07 ｨｨｨｪｨｰ02050502ｨｺｨｰｨ 0102ｨｰ02ｨｦ (Wechsler Intelligence Scale for Children-WISC-III- UK) (Wechsler D., 1992). 0609070605ｨｹ040609ｨ 05ｨｨ ｨｰｨ ｨｺ0302 ｨｺ05ｨｨｨｪｨｨｨｺ06-0709ｨｨ0106050600ｨｨ ﾂ0209ｨｺｨｨ02 ｨｨ 090602ｨｨｨ 05ｨｹｨｪ06-0709ｨｨ0106050600ｨｨ ﾂ0209ｨｺｨｨ02 ｨｬ02ｨｰ060104: ｨｨ04ｨｮ ﾂ02ｨｪｨｨ02 ｨｬｨｨｨｺ0806090602ｨｨｨ 05ｨｹｨｪ060006 06ｨｺ08ｨｮ0302ｨｪｨｨ07 ｨｨ 0908ｨ 09ｨｪｨｨｨｰ0205ｨｹｨｪ04ｨｦ ｨ ｨｪｨ 05ｨｨ04 06ｨ 08ｨ 040609ｨ ｨｰ0205ｨｹｨｪ060006 ｨｮ080609ｨｪ07 080601ｨｨｨｰ020502ｨｦ (ｨｪ0204ｨ ｨｺ06ｨｪ ﾂ02ｨｪｨｪ0602 09080201ｨｪ0202, 09080201ｨｪ0202, 09080201ｨｪ0202 09070202ｨｨｨ 05ｨｹｨｪ0602,090409030202 06ｨ 08ｨ 040609ｨ ｨｪｨｨ02). 04030507090506080604 06 02090507040203010603 020604ｨｨｨｬ02ｨｰ08ｨｨ07 020507 64 0102ｨｰ02ｨｦ ｨｨ04 0609ｨｪ0609ｨｪ06ｨｦ 0008ｨｮ070704 ｨｨ 010507 72 0102ｨｰ02ｨｦ ｨｨ04 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ 0008ｨｮ070704 0802ｨｺ06ｨｪ09ｨｰ08ｨｮｨｨ080609ｨ ｨｪｨ ｨｪｨｮ050209ｨ 07 010604ｨ 09ｨｪｨｮｨｰ0802ｨｪｨｪ020006 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 0204 131 I. 06ｨｰ06 06ｨ ｨｮ090506090502ｨｪ06,09 0609ｨｪ0609ｨｪ06ｨｬ,ｨｰ02ｨｬ 00ｨ ｨｺｨｰ06ｨｬ, ﾂｨｰ06 090806ｨｺ 000209ｨｰｨ 02ｨｨｨｨ ｨｪｨ ｨｬ06ｨｬ02ｨｪｨｰ ｨ 09ｨ 08ｨｨｨｨ ｨｪｨ ﾁ080605 090609ｨｰｨ 09050705 ｨｬ02ｨｪ0202 10 ｨｪ02010205ｨｹ ｨｨ ｨｪ02 ｨ 040506 070609ｨｰｨｮ070502ｨｪｨｨ07 08ｨ 01ｨｨ06ｨ ｨｺｨｰｨｨ09ｨｪ060006 ｨｦ0601ｨ 09 ｨｪ0208ｨ 0409ｨｨｨｰｨｮ06 0204 07050601ｨ. 05080201ｨｪｨｨ02 01060404 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 0204 131 I 09 0609ｨｪ0609ｨｪ06ｨｦ ｨｨ ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ 0008ｨｮ0707ｨ 01 090609ｨｰｨ 09ｨｨ05ｨｨ,090606ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06,390 ﾀ550 ｨｬ0108 ｨｨ 35 ﾀ65 ｨｬ0108,ｨｬ0201ｨｨｨ ｨｪ04 08ｨ 0907080201020502ｨｪｨｨ07-230 ｨｨ 14 ｨｬ0108. 05080201ｨｨ 05ｨｨ02 0609ｨｪ0609ｨｪ06ｨｦ 0008ｨｮ070704 ｨｬｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪｨ 07 ｨｨｨｪ01ｨｨ09ｨｨ01ｨｮｨ 05ｨｹｨｪｨ 07 070802ｨｪｨ ｨｰｨ 05ｨｹｨｪｨ 07 010604ｨ 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 0204 090609ｨｰｨ 09ｨｨ05ｨ 4100 ｨｬ0108. 05080201ｨｪｨｨ02 01060404 09ｨｪ0203ｨｪ020006 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 ｨｪｨ 07050601 10 ﾀ13 ｨｬ0108 ｨｨ 0,2 ﾀ0,4 ｨｬ0108 ｨ 0405ｨｨ 060202ｨｪ02ｨｪ04 010507 05ｨｨ02 0609ｨｪ0609ｨｪ06ｨｦ ｨｨ ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ 0008ｨｮ0707. 000201ｨｨｨ ｨｪｨ 08ｨ 0907080201020502ｨｪｨｨ07 010604 09ｨｪ0203ｨｪ020006 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 090609ｨｰｨ 09ｨｨ05ｨ 6 ｨｨ 0,1 ｨｬ0108 010507 05ｨｨ02 0609ｨｪ0609ｨｪ06ｨｦ ｨｨ ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ 0008ｨｮ0707. 05080201ｨｨ 05ｨｨ02 0609ｨｪ0609ｨｪ06ｨｦ 0008ｨｮ070704 ｨｬｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪｨ 07 ｨｨｨｪ01ｨｨ09ｨｨ01ｨｮｨ 05ｨｹｨｪｨ 07 ｨ ｨｪｨｰ02ｨｪｨ ｨｰｨ 05ｨｹｨｪｨ 07 010604ｨ 09ｨｪ0203ｨｪ020006 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 090609ｨｰｨ 09ｨｨ05ｨ 91 ｨｬ0108. 060209ｨｰ04 ｨｨｨｪｨｰ02050502ｨｺｨｰｨｮｨ 05ｨｹｨｪ060006 08ｨ 0409ｨｨｨｰｨｨ07 00 6-7-0502ｨｰｨｪ02ｨｬ 09060408ｨ 09ｨｰ02 05ｨｨ02ｨ 06ｨ 05ｨｮ ﾂ02ｨｪｨｪ06ｨｦ 0008ｨｮ070704 ｨｨｨｬ0205ｨｨ ｨ 06050202 ｨｪｨｨ04ｨｺｨｨｨｦ 09080201ｨｪｨｨｨｦ 06ｨ ｨｴｨｨｨｦ ｨｺ06050000ｨｨ02ｨｨ02ｨｪｨｰ ｨｨｨｪｨｰ02050502ｨｺｨｰｨｮｨ 05ｨｹｨｪ0609ｨｰｨｨ (IQ) 09 0908ｨ 09ｨｪ02ｨｪｨｨｨｨ 09 ｨｺ06ｨｪｨｰ08060502ｨｬ (89,6 ﾀ10,2 ｨｨ 92,1 ﾀ10,5; 08=0,007). 000407090502ｨｪ06 ｨｰｨ ｨｺ0302 06ｨｰｨｪ0609ｨｨｨｰ0205ｨｹｨｪ0602 07080206ｨ 05ｨ 01ｨ ｨｪｨｨ02 0905ｨｮ ﾂｨ 0209 "ｨｪｨｨ03ｨｪ020006 ｨｮ080609ｨｪ07 ｨｨｨｪｨｰ02050502ｨｺｨｰｨｮｨ 05ｨｹｨｪ06ｨｦ ｨｪ0608ｨｬ04" (IQ=80-89) 09 06ｨ 05ｨｮ ﾂ02ｨｪｨｪ06ｨｦ 0008ｨｮ070702,09 0908ｨ 09ｨｪ02ｨｪｨｨｨｨ 09 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ (92 (36,8%) ｨｨ 66 0102ｨｰ02ｨｦ (26,4%),090606ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06; 08=0,012). 0805ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ 0102ｨｰｨｨ 09 "ｨｪｨｨ03ｨｪｨｨｨｬ ｨｮ080609ｨｪ02ｨｬ ｨｨｨｪｨｰ02050502ｨｺｨｰｨｮｨ 05ｨｹｨｪ06ｨｦ ｨｪ0608ｨｬ04" 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ040609ｨ 05ｨｨ09ｨｹ ｨｮｨｬ020802ｨｪｨｪ06ｨｦ 04ｨ 01020803ｨｺ06ｨｦ 000608ｨｬｨｨ080609ｨ ｨｪｨｨ07 070604ｨｪｨ 09ｨ ｨｰ0205ｨｹｨｪ0401 070806020209090609, ｨｪｨｨ04ｨｺｨｨｨｬ ｨｮ080609ｨｪ02ｨｬ ｨｬ06ｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｺ 03ｨｺ0605ｨｹｨｪ06ｨｬｨｮ 06ｨ ｨｮ ﾂ02ｨｪｨｨ06 ｨｨ ｨｪ02010609ｨｰｨ ｨｰ06 ﾂｨｪ04ｨｬ ｨｮ080609ｨｪ02ｨｬ 08ｨ 0409ｨｨｨｰｨｨ07 "07080201070609040506ｨｺ ｨｨｨｪｨｰ02050502ｨｺｨｰｨ " (ｨ ｨｺｨｰｨｨ09ｨｪ060006 09ｨｪｨｨｨｬｨ ｨｪｨｨ07, ｨｺ08ｨ ｨｰｨｺ06090802ｨｬ02ｨｪｨｪ06ｨｦ 07ｨ ｨｬ07ｨｰｨｨ, ｨｺ06ｨｪ09ｨｰ08ｨｮｨｺｨｰｨｨ09ｨｪ060006 0708ｨ ｨｺ09ｨｨ09ｨ ｨｨ ｨｰ.01.). 0102 090407090502ｨｪ06 09ｨｰｨ ｨｰｨｨ- 111
of the exposed and control groups at the age 10-12 years (94.3 ﾀ10.4 vs. 95.8 ﾀ10.9, p=0.117), and at the age 15-16 years (98.2 ﾀ10.7 vs. 99.5 ﾀ10.5, p=0.171). Dynamics of IQ in persons of exposed and control group from the age of 6-7 years till the age of 15-16 years are given in table 2. 09ｨｰｨｨ ﾂ0209ｨｺｨｨ 010609ｨｰ06090208ｨｪ0401 08ｨ 0405ｨｨ ﾂｨｨｨｦ 09080201ｨｪｨｨ01 IQ 06ｨ 05ｨｮ ﾂ02ｨｪｨｪ06ｨｦ ｨｨ ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ 0008ｨｮ0707 09 09060408ｨ 09ｨｰ02 10-12 0502ｨｰ (94,3 ﾀ10,4 ｨｨ 95,8 ﾀ10,9; 08=0,117) ｨｨ 09 09060408ｨ 09ｨｰ02 15-16 0502ｨｰ (98,2 ﾀ10,7 ｨｨ 99,5 ﾀ10,5; 08=0,171). 02ｨｨｨｪｨ ｨｬｨｨｨｺｨ IQ 05ｨｨ02 06ｨ 05ｨｮ ﾂ02ｨｪｨｪ06ｨｦ ｨｨ ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ 0008ｨｮ0707 09 09060408ｨ 09ｨｰ02 06ｨｰ 6-7 0106 15-16 0502ｨｰ 0708ｨｨ09020102ｨｪｨ 09 ｨｰｨ ｨ 05ｨｨ0202 2. DYNAMICS OF INTELLECTUAL DEVELOPMENT IN PERSONS OF EXPOSED AND CONTROL GROUP FROM THE AGE OF 6-7, 10-12 AND 15-16 YEARS Full Scale Intelligence Quotient (IQ) Exposed group 0206010800060808 070402000108 IQ 090600 0205010200010207 06 0802010604020905010207 0104070303 00 0002050408050603 6-7, 10-12 06 15-16 090306 Persons of group at the age of 66ﾓ17 years 106ﾓ112 years 156ﾓ116 years* N % N % N % ﾝ 90 (average and high average range) 125 50.0 177 70.8 206 84.1 80-89 (low average range) 92 36.8 56 22.4 28 11.4 70-79 (borderline intellectual functioning) 27 10.8 11 4.4 6 2.5 ﾜ 69 (exceptionally low range) 6 2.4 6 2.4 5 2.0 Control group ﾝ 90 (average and high average range) 158 63.2 193 77.2 195 81.5 80-89 (low average range) 66 26.4 42 16.8 37 15.5 70-79 (borderline intellectual functioning) 22 8.8 10 4.0 3 1.3 ﾜ 69 (exceptionally low range) 4 1.6 5 2.0 4 1.7 Note. *Due to migration at the age 15-16 years 5 persons had left the exposed group and 11 persons had left the control group. 0308ｨｨｨｬ02 ﾂｨ ｨｪｨｨ02. *0604-04ｨ ｨｬｨｨ0008ｨ 02ｨｨｨｨ 5 ﾂ0205060902ｨｺ 0706ｨｺｨｨｨｪｨｮ05ｨｨ 0609ｨｪ0609ｨｪｨｮ06 0008ｨｮ0707ｨｮ ｨｨ 11 ﾂ0205060902ｨｺ 0706ｨｺｨｨｨｪｨｮ05ｨｨ ｨｺ06ｨｪｨｰ080605ｨｹｨｪｨｮ06 0008ｨｮ0707ｨｮ. TABLE 2 06080909060008 2 The distribution of IQ among persons of the exposed group for the gestational age at the time of the Chernobyl accident is given in table 3. No statistically significant differences in average IQ were found between subgroups. The distribution of average IQ among persons of the exposed group in relation to the thyroid dose from 131 I ranges is given in table 4. Subgroup of persons with thyroid doses over 1,000 mgy had relatively lower mean full-scale IQ compared to the entire exposed group at the age 6-7 years (86.5 ﾀ7.4 vs. 89.6 ﾀ10.2, p=0.162), at the age 10-12 years (90.0 ﾀ7.9 vs. 94.3 ﾀ10.4, p=0.066), and at the age 15-16 years (94.1 ﾀ9.4 vs. 98.2 ﾀ10.7, p=0.091). No significant correlation was also found in exposed group between individual thyroid dose from 131 I and IQ at the age of 6-7 years (r = -0.11; 08>0.1),at the age of 10-12 years (r = -0.21; 08>0.1),and at the age of 15-16 years (r = -0.29; 08>0.05) (figure 1). 112 04ｨ 0907080201020502ｨｪｨｨ02 IQ 05ｨｨ02 06ｨ 05ｨｮ ﾂ02ｨｪｨｪ06ｨｦ 0008ｨｮ070704 09 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ 090806ｨｺｨ 000209ｨｰｨ 02ｨｨｨｨ ｨｪｨ ｨｬ06ｨｬ02ｨｪｨｰ ｨ 09ｨ 08ｨｨｨｨ ｨｪｨ ﾁ0208ｨｪ06ｨ 0405ｨｹ09ｨｺ06ｨｦ 080605 0708ｨｨ09020102ｨｪ06 09 ｨｰｨ ｨ 05ｨｨ0202 3. 05ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨｨ 010609ｨｰ06090208ｨｪ0401 08ｨ 0405ｨｨ ﾂｨｨｨｦ 09080201ｨｪｨｨ01 IQ ｨｬ020301ｨｮ 0706010008ｨｮ0707ｨ ｨｬｨｨ ｨｪ02 ｨｪｨ ｨ 050601ｨ 050609ｨｹ. THE DISTRIBUTION OF IQ AMONG THE PERSONS OF THE EXPOSED GROUP IN RELATION TO THE GESTATIONAL AGE AT THE TIME OF THE CHERNOBYL ACCIDENT 04080503040302030903010603 IQ 090600 0205010200010207 010407030304 00 0508000605060002050606 0206 0504020808 0103050608000606 0108 000200030106 080008040606 0108 ﾁ080605 Gestational age, weeks Full scale IQ (mean ﾀ SD) N 66ﾓ17 years 106ﾓ112 years 156ﾓ116 years 06ﾓ17 59 87.1 ﾀ 12.1 91.8 ﾀ 13.0 95.8 ﾀ 13.0 86ﾓ115 53 89.6 ﾀ 8.8 95.4 ﾀ 8.7 99.7 ﾀ 9.4 166ﾓ125 56 89.4 ﾀ 9.8 94.0 ﾀ 9.9 98.1 ﾀ 10.0 > 25 82 91.5 ﾀ 9.5 95.5 ﾀ 9.6 99.1 ﾀ 10.0 Total 250 89.6 ﾀ 10.2 94.3 ﾀ 10.4 98.2 ﾀ 10.7 TABLE 3 06080909060008 3 04ｨ 0907080201020502ｨｪｨｨ02 ｨｨｨｪｨｰ02050502ｨｺｨｰｨｮｨ 05ｨｹｨｪ0401 0706ｨｺｨ 04ｨ ｨｰ020502ｨｦ 05ｨｨ02 06ｨ 05ｨｮ ﾂ02ｨｪｨｪ06ｨｦ 0008ｨｮ070704 09 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ ｨｮ080609ｨｪ07 01060404 ｨ ｨｪｨｰ02ｨｪｨ ｨｰｨ 05ｨｹｨｪ060006 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 0204 131 I 0708ｨｨ09020102ｨｪ06 09 ｨｰｨ ｨ 05ｨｨ0202 4. IQ 05ｨｨ02, 01060404 ｨ ｨｪｨｰ02ｨｪｨ ｨｰｨ 05ｨｹｨｪ060006 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 0204 ｨｺ06ｨｰ06080401 070802090403ｨ 06ｨｰ 1000 ｨｬ0108, ｨ 0405ｨｨ 06ｨｰｨｪ0609ｨｨｨｰ0205ｨｹｨｪ06 ｨｪｨｨ0302, ﾂ02ｨｬ 0706 06ｨ 05ｨｮ ﾂ02ｨｪｨｪ06ｨｦ 0008ｨｮ070702 09 02020506ｨｬ, 09 09060408ｨ 09ｨｰ02 6-7 0502ｨｰ (86,5 ﾀ7,4 ｨｨ 89,6 ﾀ10,2; 08=0,162), 09 10-12 0502ｨｰ (90,0 ﾀ7,9 ｨｨ 94,3 ﾀ10,4; 08=0,066) ｨｨ 09 15-16 0502ｨｰ (94,1 ﾀ9,4 ｨｨ 98,2 ﾀ10,7; 08=0,091). 0102 090407090502ｨｪ06 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨｨ 010609ｨｰ06090208ｨｪ06ｨｦ ｨｺ06080802050702ｨｨ06ｨｪｨｪ06ｨｦ 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ ｨｬ020301ｨｮ ｨｨｨｪ01ｨｨ09ｨｨ01ｨｮｨ 05ｨｹｨｪ06ｨｦ 01060406ｨｦ ｨ ｨｪｨｰ02ｨｪｨ ｨｰｨ 05ｨｹｨｪ060006 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 0204 131 I ｨｨ IQ 09 09060408ｨ 09ｨｰ02 6-7 0502ｨｰ (r=-0,11; 08>0,1),10-12 0502ｨｰ (r=-0,21; 08>0,1) ｨｨ 15-16 0502ｨｰ (r=-0,29; 08>0,05) (08ｨｨ09ｨｮｨｪ06ｨｺ 1).
THE DISTRIBUTION OF IQ AMONG THE PERSONS OF THE EXPOSED GROUP IN RELATION TO THE THYROID DOSE RANGES 04080503040302030903010603 IQ 090600 0205010200010207 010407030304 00 0508000605060002050606 0206 02020504 0801060301080608090501020102 02090907 ﾁ03010608 0204 TABLE 4 06080909060008 4 Thyroid dose range, Full scale IQ (mean ﾀ SD) N mgy 66ﾓ17 years 106ﾓ112 years 156ﾓ116 years 0 72 87.6 ﾀ10.9 92.2 ﾀ11.5 98.3 ﾀ11.9 106ﾓ1299 63 91.7 ﾀ8.3 96.7 ﾀ7.2 100.7 ﾀ8.9 3006ﾓ1599 62 89.18 ﾀ9.7 93.9 ﾀ10.6 98.9 ﾀ9.9 6006ﾓ1999 32 90.8 ﾀ10.8 95.3 ﾀ10.5 98.4 ﾀ9.7 > 1000 21 86.5 ﾀ7.4 90.0 ﾀ7.9 94.1 ﾀ9.4 Total 250 89.6 ﾀ10.2 94.3 ﾀ10.4 98.2 ﾀ10.7 FIGURE 1. DEPENDENCE OF FULL-SCALE IQ FROM INDIVIDUAL THYROID DOSES FROM AT THE AGE OF 15-16 YEARS AMONG PERSONS OF EXPOSED GROUP 04060507010208 1. 0508000605060002050605 0209020609 06010603090903080607080905010409 0302080805080603090307 (IQ) 00 0002050408050603 15-16 090306 06 0601020600060207080905010207 02020504 0801060301080608090501020102 02090907 ﾁ03010608 0204 020908 090600 0205010200010207 010407030304 The distribution of average IQ among the persons of the exposed group in relation to the external dose ranges is given in table 5. Subgroup of persons with the highest external antenatal doses (over than 30 mgy) has relatively lower mean full-scale IQ compared to the whole exposed group at the age 6-7 years (85.5 ﾀ6.3 vs. 89.6 ﾀ10.2; p=0.185), at the age 10-12 years (90.2 ﾀ6.3 vs. 94.3 ﾀ10.4; p=0.199),and at the age 15-16 years (92.4 ﾀ9.4 vs. 98.2 ﾀ10.7; p=0.057). At the same time,no statistically significant correlation was found in exposed group between individual external antenatal dose and IQ at the age of 6-7 years (r=-0.14),at the age of 10-12 years (r=-0.13), and at the age of 15-16 years (r=- 0.19). Figure 2 shows dependence of full-scale IQ from individual external antenatal doses at the age of 15-16 years among persons of exposed group. 04ｨ 0907080201020502ｨｪｨｨ02 IQ 05ｨｨ02 06ｨ 05ｨｮ ﾂ02ｨｪｨｪ06ｨｦ 0008ｨｮ070704 09 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ ｨｮ080609ｨｪ07 01060404 ｨ ｨｪｨｰ02ｨｪｨ ｨｰｨ 05ｨｹｨｪ060006 09ｨｪ0203ｨｪ020006 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 0706ｨｺｨ 04ｨ ｨｪ06 09 ｨｰｨ ｨ 05ｨｨ0202 5. 0306010008ｨｮ0707ｨ ｨｨ04 11 05ｨｨ02 09 ｨｪｨ ｨｨｨ 06050202 09040906ｨｺｨｨｨｬｨｨ 010604ｨ ｨｬｨｨ ｨ ｨｪｨｰ02ｨｪｨ ｨｰｨ 05ｨｹｨｪ060006 09ｨｪ0203ｨｪ020006 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 (ｨ 06050202 30 ｨｬ0108) 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ040609ｨ 05ｨ 09ｨｹ ｨ 06050202 ｨｪｨｨ04ｨｺｨｨｨｬ IQ 09 0908ｨ 09ｨｪ02ｨｪｨｨｨｨ 09 06ｨ 05ｨｮ ﾂ02ｨｪｨｪ06ｨｦ 0008ｨｮ070706ｨｦ 09 02020506ｨｬ 09 09060408ｨ 09ｨｰ02 6-7 0502ｨｰ (85,5 ﾀ6,3 ｨｨ 89,6 ﾀ10,2 090606ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06; 08=0,185),09 09060408ｨ 09ｨｰ02 10-12 0502ｨｰ (90,2 ﾀ6,3 ｨｨ 94,3 ﾀ10,4; 08=0,199) ｨｨ 09 09060408ｨ 09ｨｰ02 15-16 0502ｨｰ (92,4 ﾀ9,4 ｨｨ 98,2 ﾀ10,7; 08=0,057). 00 ｨｰ06 0302 090802ｨｬ07, 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨｨ 04ｨｪｨ ﾂｨｨｨｬ06ｨｦ ｨｺ06080802050702ｨｨｨｨ ｨｬ020301ｨｮ 010604ｨ ｨｬｨｨ 09ｨｪ0203ｨｪ020006 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 ｨｰ0205ｨ 07050601ｨ ｨｨ 0706ｨｺｨ 04ｨ ｨｰ020507ｨｬｨｨ ｨｨｨｪｨｰ02050502ｨｺｨｰｨｮｨ 05ｨｹｨｪ060006 08ｨ 0409ｨｨｨｰｨｨ07 09 09060408ｨ 09ｨｰ02 6-7 (r = -0,14), 10-12 (r = -0,13),ｨｨ 15-16 0502ｨｰ (r = -0,20) 090407090502ｨｪ06 ｨｪ02 ｨ 040506. 04ｨｨ09ｨｮｨｪ06ｨｺ 2 0706ｨｺｨ 040409ｨ 02ｨｰ 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｹ 06ｨ ｨｴ020006 IQ 09 09060408ｨ 09ｨｰ02 15-16 0502ｨｰ 06ｨｰ ｨｨｨｪ01ｨｨ09ｨｨ01ｨｮｨ 05ｨｹｨｪ06ｨｦ 01060404 ｨ ｨｪｨｰ02ｨｪｨ ｨｰｨ 05ｨｹｨｪ060006 09ｨｪ0203ｨｪ020006 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 010507 05ｨｨ02 06ｨ 05ｨｮ ﾂ02ｨｪｨｪ06ｨｦ 0008ｨｮ070704. 113
TABLE 5 THE DISTRIBUTION OF IQ AMONG THE PERSONS OF THE EXPOSED GROUP IN RELATION TO THE EXTERNAL ANTENATAL DOSE RANGES 06080909060008 5 04080503040302030903010603 IQ 090600 0205010200010207 010407030304 00 0508000605060002050606 0206 02020504 0801060301080608090501020102 0001030101030102 02090907 ﾁ03010608 External dose range, Full scale IQ (mean ﾀ SD) N mgy 66ﾓ17 years 106ﾓ112 years 156ﾓ116 years < 2.99 54 90.9 ﾀ11.3 95.1 ﾀ11.3 98.8 ﾀ11.4 3.06ﾓ15.99 70 91.2 ﾀ9.9 96.0 ﾀ10.8 100.0 ﾀ10.9 6.06ﾓ19.99 52 90.1 ﾀ10.6 94.3 ﾀ10.5 98.5 ﾀ10.2 10.06ﾓ129.99 63 87.0 ﾀ9.4 92.2 ﾀ9.5 96.7 ﾀ9.9 > 30.0 11 85.5 ﾀ6.3 90.2 ﾀ6.3 92.4 ﾀ9.6 Total 250 89.6 ﾀ10.2 94.3 ﾀ10.4 98.2 ﾀ10.7 FIGURE 2. DEPENDENCE OF FULL-SCALE IQ FROM INDIVIDUAL EXTERNAL ANTENATAL DOSES AT THE AGE OF 15-16 YEARS AMONG PERSONS OF EXPOSED GROUP 04060507010208 2. 0508000605060002050605 0209020609 06010603090903080607080905010409 0302080805080603090307 (IQ) 00 0002050408050603 15-16 090306 06 0601020600060207080905010207 02020504 0801060301080608090501020102 0001030101030102 02090907 ﾁ03010608 020908 090600 0205010200010207 010407030304 Family study In the exposed group we found a positive moderate correlation between the IQ of persons and the educational level of their parents - mothers (r=0.50; p<0.01) and fathers (r=0.52; p<0.01). A weaker correlation was found between the intellectual level of persons of the control group and the educational level of their parents - mothers (r=0.41; p<0.05) and fathers (r=0.42; p<0.05). CONCLUSIONS 1. The positive dynamics of intellectual development in persons of exposed group has been observed at the age from 6-7 till 15-16. 2. No statistically significant correlation was found in exposed group between individual thyroid dose as well as individual antenatal external dose and IQ at the age of 6-7 years, 10-12 years, and 15-16 years. 3. Disorders of intellectual development in the exposed group of children were caused mainly by unfavorable social-psychological and social-cultural factors such as a low educational level of parents, break of microsocial contacts and difficulties of adaptation,which appeared in the wake of the evacuation and relocation from the contaminated areas. 0609090502010609ｨ ｨｪｨｨ02 0902ｨｬ02ｨｦｨｪ060006 06ｨｺ08ｨｮ0302ｨｪｨｨ07 00 06ｨ 05ｨｮ ﾂ02ｨｪｨｪ06ｨｦ 0008ｨｮ070702 09040709ｨｨ05ｨｨ 0706050603ｨｨｨｰ0205ｨｹｨｪｨｮ06 ｨｺ06080802050702ｨｨ06ｨｪｨｪｨｮ06 0904ｨ ｨｨｨｬ0609090704ｨｹ IQ 0102ｨｰ02ｨｦ 0609ｨｪ0609ｨｪ06ｨｦ 0008ｨｮ070704 ｨｨ 06ｨ 08ｨ 040609ｨ ｨｰ0205ｨｹｨｪ060006 ｨｮ080609ｨｪ07 ｨｨ01 080601ｨｨｨｰ020502ｨｦ - ｨｬｨ ｨｰ020802ｨｦ (r = 0,50; p<0,01 ) ｨｨ 06ｨｰ020609 (r= 0,52; p<0,01). 0906050202 ｨｪｨｨ04ｨｺｨ 07 ｨｺ06080802050702ｨｨ07 ｨ 0405ｨ 090407090502ｨｪｨ ｨｬ020301ｨｮ ｨｨｨｪｨｰ02050502ｨｺｨｰｨｮｨ 05ｨｹｨｪ04ｨｬ ｨｮ080609ｨｪ02ｨｬ 05ｨｨ02 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ 0008ｨｮ070704 ｨｨ 06ｨ 08ｨ 040609ｨ ｨｰ0205ｨｹｨｪ04ｨｬ ｨｮ080609ｨｪ02ｨｬ ｨｨ01 080601ｨｨｨｰ020502ｨｦ (010507 ｨｬｨ ｨｰ020802ｨｦ r = 0,41; p<0,01; 010507 06ｨｰ020609 r = 0,42; p<0,01). 000400020204 1.06ｨｪｨｰ02050502ｨｺｨｰｨｮｨ 05ｨｹｨｪ0602 08ｨ 0409ｨｨｨｰｨｨ02 05ｨｨ02 06ｨ 05ｨｮ ﾂ02ｨｪｨｪ06ｨｦ 0008ｨｮ070704 09 09060408ｨ 09ｨｰ02 06ｨｰ 6-7 0106 15-16 0502ｨｰ 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ040609ｨ 050609ｨｹ 0706050603ｨｨｨｰ0205ｨｹｨｪ06ｨｦ 01ｨｨｨｪｨ ｨｬｨｨｨｺ06ｨｦ. 2. 00 06ｨ 05ｨｮ ﾂ02ｨｪｨｪ06ｨｦ 0008ｨｮ070702 ｨｪ02 090407090502ｨｪ06 ｨｺ06080802050702ｨｨ06ｨｪｨｪ06ｨｦ 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ ｨｨｨｪ01ｨｨ09ｨｨ01ｨｮｨ 05ｨｹｨｪ0401 010604 ｨ ｨｪｨｰ02ｨｪｨ ｨｰｨ 05ｨｹｨｪ060006 06ｨ 05ｨｮ- ﾂ02ｨｪｨｨ07 0204 ｨｨ ｨ ｨｪｨｰ02ｨｪｨ ｨｰｨ 05ｨｹｨｪ060006 09ｨｪ0203ｨｪ020006 06ｨ 05ｨｮ ﾂ02ｨｪｨｨ07 ｨｨ IQ 09 09060408ｨ 09ｨｰ02 6-7 0502ｨｰ,10-12 0502ｨｰ ｨｨ 15-160502ｨｰ. 3. 0209ｨｪ0609ｨｪｨｮ06 080605ｨｹ 09 070806ｨｨ090106030102ｨｪｨｨｨｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ ｨｨｨｪｨｰ02050502ｨｺｨｰｨｮｨ 05ｨｹｨｪ060006 08ｨ 0409ｨｨｨｰｨｨ07 09 06ｨ 05ｨｮ ﾂ02ｨｪｨｪ06ｨｦ 0008ｨｮ070702 0102ｨｰ02ｨｦ ｨｨ0008ｨ 05ｨｨ ｨｪ02ｨ 05ｨ 00060708ｨｨ07ｨｰｨｪ0402 0709ｨｨ0106050600ｨｨ ﾂ0209ｨｺｨｨ02 ｨｨ 090602ｨｨｨ 05ｨｹｨｪ06-0102ｨｬ060008ｨ 00ｨｨ ﾂ0209ｨｺｨｨ02 00ｨ ｨｺｨｰ060804, ｨｰｨ ｨｺｨｨ02 ｨｺｨ ｨｺ ｨｪｨｨ04ｨｺｨｨｨｦ 06ｨ 08ｨ 040609ｨ ｨｰ0205ｨｹｨｪ04ｨｦ ｨｮ08060902ｨｪｨｹ 080601ｨｨｨｰ020502ｨｦ, 010200ｨｨ02ｨｨｨｰ ｨｨｨｪ000608ｨｬｨ 02ｨｨｨｨ, 08ｨ 04080409 ｨｬｨｨｨｺ0806090602ｨｨｨ 05ｨｹｨｪ0401 ｨｺ06ｨｪｨｰｨ ｨｺｨｰ0609 ｨｨ ｨｰ08ｨｮ01ｨｪ0609ｨｰｨｨ ｨ 01ｨ 07ｨｰｨ 02ｨｨｨｨ, 090604ｨｪｨｨｨｺ03ｨｨ02 09 0708060202090902 0702080209020502ｨｪｨｨ07 ｨｨ04 070609ｨｰ08ｨ 01ｨ 0903ｨｨ01 08ｨ ｨｦ06ｨｪ0609. 114
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