The vaginal smears obtained from a 63-year-old woman revealed malignant features such as hyperchromasia, coarse gnanular chromatin and enlarge- ment of N/C ratio. Tadpole and fiber shaped malignant cells were also seen. The smear cytological diagnosis was Pap. class and early invasive carcinoma. The punch biopsy IV specimen obtained from uterine cervix was histologically interpreted as epidermoid carcinoma. She underwent bilateral sarpingoophorectomy. The tumors measuring about 15 cm in diameter was histologically interpreted as serous cystadenocarcinoma. In tumor stamping smears and in ascites, the grape-like clusters were seen and composed of malignant cells with prominent nucleoli and vacuole.
- Morphological properties of carcinosarcoma in smear cytology and in vitro culture- A 50-year-old woman, gravida 2, para 2, noticed postmenopausal uterine bleeding after 3 months. The uterus was fist size and a tumor was prot- from the cervical OS. ruding Smear cytology: Malignant cells with prominent nucleoli and large vacuoli in grape-like clusters and fibrous shaped neoplastic cells were seen in the curattage smears of the uterine cavity. Cytological diagnosis was Pap. class V, and suspected carcinosarcoma. Culture cell: The tumors (leiomyosarcoma plus adenocarcinoma) were placed into culture on June 22, 1979. The cultured cells were composed of two types (sarcoma cell and adenocarcinoma cell) The nuclei revealed neoplastic features such as a bizarre aggregation of chromatin granules, an. irregular thickening membrane, and multiple large nucleoli. -A case of uteruscarcinosarcoma-