1306ｨｺ09070208ｨｰｨｪ0602 ｨｬｨｪ02ｨｪｨｨ02 01060503ｨｪ06 ｨ 04ｨｰｨｹ 090609ｨｰ0802ｨ 0609ｨ ｨｪ06! 01 1 (3) 2011 040201ｨ ｨｺ02ｨｨ06ｨｪｨｪｨ 07 ｨｺ0605050200ｨｨ07 010609ｨｮ01ｨ 0809ｨｰ0902ｨｪｨｪ0602 06ｨ 08ｨ 040609ｨ ｨｰ0205ｨｹｨｪ0602 ｨｮ ﾂ0802030102ｨｪｨｨ02 09040903020006 07080600020909ｨｨ06ｨｪｨ 05ｨｹｨｪ060006 06ｨ 08ｨ 040609ｨ ｨｪｨｨ07 0004060909ｨｨｨｦ09ｨｺｨｨｨｦ 000609ｨｮ01ｨ 0809ｨｰ0902ｨｪｨｪ04ｨｦ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨｨｦ ｨｮｨｪｨｨ09020809ｨｨｨｰ02ｨｰ 0802010208ｨ 05ｨｹｨｪ060006 ｨ 0002ｨｪｨｰ09ｨｰ09ｨ 0706 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ06 ｨｨ 090602ｨｨｨ 05ｨｹｨｪ06ｨｬｨｮ 08ｨ 0409ｨｨｨｰｨｨ0603 (010207 000302 04010007 040609040108ｨ 09ｨ ) 0806ｨｪ01 08ｨ 0409ｨｨｨｰｨｨ07 090602ｨｨｨ 05ｨｹｨｪ06ｨｦ 070605ｨｨｨｰｨｨｨｺｨｨ ｨｨ 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07 00010205ｨｨ060903 0308ｨｨ 07060101020803ｨｺ02 0806ｨｬｨｨｨｰ02ｨｰｨ 0706 090602ｨｨｨ 05ｨｹｨｪ06ｨｦ 070605ｨｨｨｰｨｨｨｺ02 ｨｨ 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ06 05060902ｨｰｨ 0802010208ｨ 02ｨｨｨｨ 0802010208ｨ 05ｨｹｨｪ060006 0506ｨ 08ｨ ｨｪｨｨ07 04060909ｨｨｨｦ09ｨｺ06ｨｦ 0802010208ｨ 02ｨｨｨｨ 040201ｨ ｨｺ02ｨｨ07: 00. 00. 02ｨｬ0205ｨｹ07ｨｪ060909ｨｺｨｨｨｦ 0005ｨ 09ｨｪ04ｨｦ 080201ｨ ｨｺｨｰ0608 00. 00. 0809ｨｺ0902ｨｪｨｰｨｹ0209ｨ 04ｨ ｨｬ. 0005. 080201ｨ ｨｺｨｰ0608ｨ 05. 01. 080604050609 ｨｪｨ ｨｮ ﾂｨｪ04ｨｦ 080201ｨ ｨｺｨｰ0608 03. 01. 00020104ｨｪ09ｨｺｨ 07 04ｨ 090201ｨｮ06ｨｴｨ 07 080201ｨ ｨｺ02ｨｨ02ｨｦ 0801080209 080201ｨ ｨｺ02ｨｨｨｨ: 04060909ｨｨ07, 127473, 00. 000609ｨｺ09ｨ, ｨｮ05. 0808ｨ 09ｨｪ060708060502ｨｰｨ 0809ｨｺｨ 07, 0106ｨｬ 16, 09ｨｰ08. 1. 060205.: + 7 (495) 921-1089 E-mail: fondhelios@yandex.ru 060401ｨ ｨｰ0205ｨｹ: 060401ｨ ｨｰ0205ｨｹ09ｨｰ0906 00080605ｨｨｨｮｨｬ03 0801080209 ｨｨ0401ｨ ｨｰ0205ｨｹ09ｨｰ09ｨ : 04060909ｨｨ07, 127238, 00. 000609ｨｺ09ｨ 02ｨｬｨｨｨｰ08060909ｨｺ0602 0306090902, 0106ｨｬ 58. 060205.: + 7 (495) 482-5544 E-mail: info@folium.ru 0509ｨｨ0102ｨｰ0205ｨｹ09ｨｰ0906 06 080200ｨｨ09ｨｰ08ｨ 02ｨｨｨｨ 0306 01 080577-41344, 090401ｨ ｨｪ06 21 ｨｨ060507 2010 00. 0802010208ｨ 05ｨｹｨｪ06ｨｦ 0905ｨｮ03ｨ 06ｨｦ 0706 ｨｪｨ 01040608ｨｮ 09 0900020802 09090704ｨｨ, ｨｨｨｪ000608ｨｬｨ 02ｨｨ06ｨｪｨｪ0401 ｨｰ0201ｨｪ06050600ｨｨｨｦ ｨｨ ｨｬｨ 090906090401 ｨｺ06ｨｬｨｬｨｮｨｪｨｨｨｺｨ 02ｨｨｨｦ (040609ｨｺ06ｨｬｨｪｨ 01040608). 06ｨｨ08ｨ 03 ｪ 3000 05ｨｺ04. 03080201090201ｨ ｨｰ0205ｨｹ 040201ｨ ｨｺ02ｨｨ06ｨｪｨｪ06ｨｦ ｨｺ0605050200ｨｨｨｨ 01. 01. 0006050601ｨｨｨｪ 0802ｨｺｨｰ0608 04060909ｨｨｨｦ09ｨｺ060006 000609ｨｮ01ｨ 0809ｨｰ0902ｨｪｨｪ060006 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ060006 ｨｮｨｪｨｨ09020809ｨｨｨｰ02ｨｰｨ ｨｨｨｬ. 01. 06. 03ｨｨ0806000609ｨ, 01-08 ｨｬ0201. ｨｪｨ ｨｮｨｺ, 070806000209090608, ｨ ｨｺｨ 0102ｨｬｨｨｨｺ 04080001 05ｨ ｨｬ. 07080201090201ｨ ｨｰ020507 040201ｨ ｨｺ02ｨｨ06ｨｪｨｪ06ｨｦ ｨｺ0605050200ｨｨｨｨ 00. 08. 0302ｨｰ0802ｨｪｨｺ06 03080201090201ｨ ｨｰ0205ｨｹ 0806ｨｬｨｨｨｰ02ｨｰｨ 05060902ｨｰｨ 0802010208ｨ 02ｨｨｨｨ 0706 090602ｨｨｨ 05ｨｹｨｪ06ｨｦ 070605ｨｨｨｰｨｨｨｺ02 ｨｨ 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ06, 04ｨ ｨｬ0209ｨｰｨｨｨｰ0205ｨｹ 07080201090201ｨ ｨｰ020507 05060902ｨｰｨ 0706 010205ｨ ｨｬ ｨｨｨｪ09ｨ 05ｨｨ010609 0708ｨｨ 03080201090201ｨ ｨｰ020502 05060902ｨｰｨ 0802010208ｨ 02ｨｨｨｨ 0802010208ｨ 05ｨｹｨｪ060006 0506ｨ 08ｨ ｨｪｨｨ07 04060909ｨｨｨｦ09ｨｺ06ｨｦ 0802010208ｨ 02ｨｨｨｨ, 01-08 070201. ｨｪｨ ｨｮｨｺ ﾁ0502ｨｪ04 040201ｨ ｨｺ02ｨｨ06ｨｪｨｪ06ｨｦ ｨｺ0605050200ｨｨｨｨ: 01. 00. 08ｨｪｨｰ06ｨｪ0609ｨ (000609ｨｺ09ｨ ) 01. 03. 0808ｨｮｨｰ06ｨｪ0609 (000609ｨｺ09ｨ ) 00. 00. 0005ｨ 090609 (000609ｨｺ09ｨ ) 08. 09. 010201ｨｰ (000609ｨｺ09ｨ ) 05. 00. 010605ｨ ｨｪｨｰ (05ｨ ｨｪｨｺｨｰ-0302ｨｰ0208ｨ ｨｮ0800) 00. 08. 02ｨｬｨｨｨｰ08ｨｨ0209 (000609ｨｺ09ｨ ) 08. 05. 080605ｨ ｨｨｨｪ (05ｨ ｨｪｨｺｨｰ-0302ｨｰ0208ｨ ｨｮ0800) 00. 00. 090206ｨｪ0609ｨ (000609ｨｺ09ｨ ) 03. 08. 00ｨ ｨｺ09ｨｨｨｬｨｺｨｨｨｪｨ (000609ｨｺ09ｨ ) 08. 03. 000203ｨｺ060909ｨｺｨｨｨｦ (000609ｨｺ09ｨ ) 09. 05. 01ｨ ｨｬｨ 040609ｨ -09ｨ 08ｨ ｨｪ0609ｨ (000609ｨｺ09ｨ ) 00. 07. 0502ｨｬ02ｨｪ0609 (000609ｨｺ060909ｨｺｨ 07 06ｨ 05ｨ 09ｨｰｨｹ) 08. 01. 0504 ﾂ0209 (090205ｨ 08ｨｮ09ｨｹ, 00ｨｨｨｪ09ｨｺ) 01. 01. 09ｨ ﾂｨ ｨｰ0807ｨｪ (000609ｨｺ09ｨ ) 06. 03. ﾁｨ 040609ｨ (000609ｨｺ09ｨ ) 01. 09. 01ｨｨｨｬｨ ｨｪ060909ｨｺｨｨｨｦ (000609ｨｺ09ｨ ) 00. 01. 01ｨｨ07ｨｺ0609 (000609ｨｺ09ｨ )
130003020600060105080603 06030901020902010606 020003010808 06 0004090204 01 1 2011 05020203040408010603 2 000201ｨｨ02ｨｨｨｪ09ｨｺｨｨ02 ｨｰ0201ｨｪ06050600ｨｨｨｨ 060202ｨｪｨｺｨ ｨｨ 0904ｨ 0608 0206 0403020808000606 00ｨｨ01ｨ ｨｦ050609ｨ 02. 02. 0009ｨｰｨｮ07ｨｨｨｰ0205ｨｹｨｪ0602 0905060906... 3 0209050204 0102000205060307... 4 060505090302020008010608. 080108090605. 06080503030406060508 0206ｨｺｨ 04ｨ ｨｰ0205ｨｹｨｪｨ 07 ｨｬ0201ｨｨ02ｨｨｨｪｨ 0402ｨ 080609ｨ 02. 07. 01ｨ ｨｮ ﾂｨｪ0602 06ｨ 0609ｨｪ0609ｨ ｨｪｨｨ02 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ06050600ｨｨｨｦ... 9 0805ｨｨｨｪｨｨｨｺ06-05ｨｺ06ｨｪ06ｨｬｨｨ ﾂ0209ｨｺｨｨｨｦ ｨ ｨｪｨ 05ｨｨ04 00ｨ 0800ｨｨ0209ｨ 08. 00., 09ｨ ｨｦ050609 03. 00., 08080409ｨ ｨｪ0609 06. 05., 08060809ｨｮｨｪ09ｨｺｨ 07 06. 00., 0809ｨｺ0902ｨｪｨｰｨｹ0209ｨ 00. 00. 08ｨ 08ｨｬｨ ｨｺ0605ｨｺ06ｨｪ06ｨｬｨｨ ﾂ0209ｨｺｨｨｨｦ ｨ ｨｪｨ 05ｨｨ04 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 ｨｬ02ｨｰｨｨ0507080201ｨｪｨｨ04060506ｨｪｨ ｨ 02020706ｨｪｨ ｨｰｨ (ｨ 0109ｨ ｨｪｨｰｨ ｨｪ) 0708ｨｨ 0502 ﾂ02ｨｪｨｨｨｨ ｨ ｨｰ0607ｨｨ ﾂ0209ｨｺ060006 010208ｨｬｨ ｨｰｨｨｨｰｨ ｨｨ 05ｨｺ0402ｨｬ04... 14 09ｨ ﾂｨ ｨｰ0807ｨｪ 01. 04., 05ｨｺ060806ｨ 0600ｨ ｨｰ0609ｨ 00. 06., 0000ｨ 09ｨｬｨ ｨｪ 08. 00. 07ｨｴ0208ｨ 06ｨｰ ｨ 05ｨｺ06000605ｨｨ04ｨｬｨ 010507 08ｨ ｨ 06ｨｰ0601ｨ ｨｰ020507... 22 04ｨｮ01ｨ ｨｺ0609ｨ 08. 00. 08ｨ 08ｨｬｨ ｨｺ0605ｨｺ06ｨｪ06ｨｬｨｨ ﾂ0209ｨｺｨｨ02 ｨ 090702ｨｺｨｰ04 ｨｨｨｪ00ｨ 050702ｨｨ06ｨｪｨｪ06ｨｦ ｨｨ 09ｨｪｨｮｨｰ08ｨｨ0902ｨｪｨｪ06ｨｦ ｨ ｨｪ0209ｨｰ0204ｨｨｨｨ... 29 06ｨｺ09070208ｨｰｨｪｨ 07 060202ｨｪｨｺｨ 02ｨｬ0205ｨｹ07ｨｪ060909ｨｺｨｨｨｦ 00. 00., 05ｨｮ08ｨ 00. 00., 05090203ｨｪｨｨｨｺ0609ｨ 01. 02. 0106090402 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ0402 07080207ｨ 08ｨ ｨｰ04. 08ｨ ｨｺ 060202ｨｪｨｨｨｰｨｹ ｨｨｨｪｨｪ0609ｨ 02ｨｨ06ｨｪｨｪ0609ｨｰｨｹ?... 34 0002ｨｰ060106050600ｨｨ07 02ｨｬ0205ｨｹ07ｨｪ060909ｨｺｨｨｨｦ 00. 00., 0809ｨｺ0902ｨｪｨｰｨｹ0209ｨ 00. 00., 020208ｨｺｨ ﾂ 03. 00., 05090203ｨｪｨｨｨｺ0609ｨ 01. 02. 0002ｨｰ0601ｨｨ ﾂ0209ｨｺｨｨ02 070806ｨ 0502ｨｬ04 ｨ ｨｪｨ 05ｨｨ04ｨ 09ｨｰ06ｨｨｨｬ0609ｨｰｨｨｨ 06050204ｨｪｨｨ... 42 0302090606060808 06 07030408000903010603 00 050204080002020904080103010606 0006010208ｨｪｨｨ04ｨ 02ｨｨ07 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07 000704ｨｪｨｨｨｺ0609 00. 03. 00ｨｪ02010802ｨｪｨｨ02 01ｨｨｨ 00ｨｪ0609ｨｰｨｨ ﾂ0209ｨｺｨｨ 09090704ｨ ｨｪｨｪ0401 0008ｨｮ0707 09 04060909ｨｨｨｨ 09 ｨｮ ﾂ02ｨｰ06ｨｬ ｨｬ020301ｨｮｨｪｨ 080601ｨｪ060006 060704ｨｰｨ ｨｺｨ ｨｺ 0609ｨｪ0609ｨ 070609040302ｨｪｨｨ07 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨ 0605ｨｹｨｪｨｨ ﾂｨｪ0401 ｨｮ ﾂ0802030102ｨｪｨｨｨｦ... 51 0902ｨｺｨ 0809ｨｰ0902ｨｪｨｪ0602 06ｨ 02090702 ﾂ02ｨｪｨｨ02 080605ｨ ｨｨｨｪ 08. 05., 0609ｨ ｨｪ06ｨｺ 08. 09. 06ｨｪｨｪ0609ｨ 02ｨｨ06ｨｪｨｪ0402 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ0402 0908020109ｨｰ09ｨ ｨｨ ｨｨ01 ｨｬ0209ｨｰ06 09 09ｨｨ09ｨｰ02ｨｬ02 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ060006 06ｨ 02090702 ﾂ02ｨｪｨｨ07. 57 040200ｨｨ06ｨｪ04 04060909ｨｨｨｨ 0209ｨｹｨｺｨｨｨｪｨ 03. 08., 030605ｨｮｨ 02ｨｪ020209ｨ 03. 06., 08ｨｮ04ｨｪ02020609 05. 06., 05ｨｨ0806ｨｰｨｺ06 06. 06. 05060902080302ｨｪ09ｨｰ090609ｨ ｨｪｨｨ02 060800ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ 05ｨｹ0006ｨｰｨｪ060006 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ060006 06ｨ 02090702 ﾂ02ｨｪｨｨ07 09 05ｨ ｨｬｨ 0809ｨｺ06ｨｦ 06ｨ 05ｨ 09ｨｰｨｨ 09 ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨ02ｨｬ 080605... 63 010608ｨｬｨ ｨｰｨｨ09ｨｪ0602 080200ｨｮ05ｨｨ080609ｨ ｨｪｨｨ02 05060501ｨ ｨｰ0609ｨ 06. 01., 0006ｨｦ0907ｨｺ 01. 07. 05060902080302ｨｪ09ｨｰ090609ｨ ｨｪｨｨ02 ｨｪ0608ｨｬｨ ｨｰｨｨ09ｨｪ06-0708ｨ 09060906ｨｦ ｨ ｨ 0404 09 ｨｮ09050609ｨｨ0701 ｨｬ06010208ｨｪｨｨ04ｨ 02ｨｨｨｨ 09ｨｨ09ｨｰ02ｨｬ04 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07... 67 03080600020909ｨｨ06ｨｪｨ 05ｨｹｨｪ0602 08ｨ 0409ｨｨｨｰｨｨ02 06ｨｪｨｰ020809ｨｹ06: 06ｨｪｨｪ0609ｨ 02ｨｨ06ｨｪｨｪ0402 07060101060104 ｨｺ 08020302ｨｪｨｨ06 090607080609ｨ 0706010006ｨｰ0609ｨｺｨｨ 09040906ｨｺ06ｨｺ09ｨ 05ｨｨ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 ｨｺｨ 01080609 010507 00ｨ 08ｨｬ06ｨｰ08ｨ 0905ｨｨ... 74 00030402070108040202010407 02030406 00ｨ ｨｺ09ｨｨｨｬ0609ｨ 09. 00. 00020301ｨｮｨｪｨ 080601ｨｪ04ｨｦ 060704ｨｰ 000609ｨｮ01ｨ 0809ｨｰ0902ｨｪｨｪ060006 09ｨｰｨｨｨｬｨｮ05ｨｨ080609ｨ ｨｪｨｨ07 ｨｨｨｪｨｪ0609ｨ 02ｨｨｨｦ 00ｨ 08ｨｬｨ 020209ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ06ｨｦ 06ｨｰ08ｨ 09050701 070806ｨｬ04030502ｨｪｨｪ0609ｨｰｨｨ.... 83 000805060304-0809080505 0302080609 08. 08. 080608ｨｬｨｨ080609ｨ ｨｪｨｨ02 ｨｰ0201ｨｪｨｨ ﾂ0209ｨｺｨｨ01 04ｨ 01ｨ ｨｪｨｨｨｦ 0708ｨｨ 04ｨ ｨｺｨｮ07ｨｺｨ 01 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ0401 07080207ｨ 08ｨ ｨｰ0609 04ｨ 09 ﾂ02ｨｰ ｨ 06010302ｨｰｨｪ0401 0908020109ｨｰ09.. 91 06050602040608 00020304020508 08060806ｨ 0609 01. 00., 09ｨｨ ﾂ02ｨｪ0609ｨ 08. 08., 0809060809ｨｺｨｨｨｦ 08. 01. 02ｨｰ02 ﾂ0209ｨｰ0902ｨｪｨｪ0402 ｨｨｨｪｨｪ0609ｨ 02ｨｨ06ｨｪｨｪ0402 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ0402 0908020109ｨｰ09ｨ : 09ｨｰｨ ｨｰｨｮ09 09ｨｨｨｪｨｰ02ｨｰｨｨ ﾂ0209ｨｺｨｨ01 070207ｨｰｨｨ01ｨｪ0401 07080207ｨ 08ｨ ｨｰ0609... 98 08 0500030203010607 08000602040200... 103 Medical technology assessment and choice EDITORIAL COLUMN Mikhailova D. O. Opening remarks... 3 NEWS DIGEST... 4 RESEARCH. ANALYSIS. EXAMINATION Evidence-Based Medicine Rebrova O. Yu. Scientific substantiation of medical technologies ｯ efficacy... 9 Clinical and Economic Analysis Margieva A. V., Hajlov P. M., Krysanov I. S., Korsunskaja I. M., Avxentyeva M. V. Pharmacoeconomic analysis of Methylprednisolone aceponate (Advantan) for treatment of atopic dermatitis and eczema... 14 Clinical and Economic Analysis Khachatryan G. R., Skorobogatova V. I., Tsfasman F. M. The burden of alcoholism on an employer... 22 Rudakova A. V. Pharmacoeconomic aspects of inhalation and intravenous anesthesia... 29 Expert Evaluation Omelianovsky V. V., Sura M. V., Sveshnikova N. D. New pharmaceuticals. How can innovativeness be assessed?... 34 Methodology Omelyanovsky V. V., Avxentyeva M. V., Derkach E. V., Sveshnikova N. D. Methodological issues of cost of illness analysis.. 42 POLITICS AND GOVERNANCE IN HEALTHCARE Upgrading Health Vyaznikov V. E. Introduction of internationally accepted Diagnosis-Related Groups methodology in Russia as a factor of increasing effectiveness of hospitals... 51 Drug Provision Kolbin A. S., Ivanuk A. B. Innovative pharmaceuticals and their place in drug supply system... 57 Regions of Russia Oskina E. A., Polubentseva E. I., Kuznetsov S. I., Sirotko I. I. Improvement of Drug Supply for privileged groups of population in Samara region with use of automated information systems... 63 Normative Regulation Soldatova I. G., Moisyak G. Yu. Improving normative and regulatory environment within the framework of healthcare system modernization project... 67 Professional Development Interview: Innovative approaches to addressing the issue of training highly skilled specialists for the pharmaceutical industry 74 INTERNATIONAL EXPERIENCE Maksimova L. V. International experience of state incentives for innovation in pharmaceutical and medical industries... 83 MASTER CLASS Perov K. A. Developing tender specifications for procuring drugs for public needs... 91 BACKGROUND Korobov N. V., Bichenova K. A., Yavorsky A. N. Domestic innovative drugs: synthetic peptides prospects... 98 TO AUTHORS... 103
130009ｨｰｨｮ07ｨｨｨｰ0205ｨｹｨｪ0602 0905060906 0709ｨ 03ｨ 02ｨｬ0402 ﾂｨｨｨｰｨ ｨｰ0205ｨｨ! 0206 0403020808000606 0302080904ｨｦ ｨｪ06ｨｬ0208 2011 00 03ｨｮ08ｨｪｨ 05ｨ 00000201ｨｨ02ｨｨｨｪ09ｨｺｨｨ02 ｨｰ0201ｨｪ06050600ｨｨｨｨ. 020202ｨｪｨｺｨ ｨｨ 0904ｨ 060803 0706090907ｨｴ02ｨｪ 090607080609ｨ ｨｬ ｨｨｨｪｨｪ0609ｨ 02ｨｨ06ｨｪｨｪ0401 08020302ｨｪｨｨｨｦ 09 09ｨｨ09ｨｰ02ｨｬ02 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07. 0906 ﾂｨｮ 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ 09040906ｨｺｨｮ06 ｨ ｨｺｨｰｨｮｨ 05ｨｹｨｪ0609ｨｰｨｹ 05ｨｰ06ｨｦ ｨｰ02ｨｬ04 ｨｨ ｨｬ06ｨｦ 0702080906ｨｪｨ 05ｨｹｨｪ04ｨｦ ｨｨｨｪｨｰ02080209 ｨｺ 01ｨ ｨｪｨｪ06ｨｦ 070806ｨ 0502ｨｬ02. 04ｨ 0409ｨｨｨｰｨｨ02 00ｨ 08ｨｬｨ 020209ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ06ｨｦ ｨｪｨ ｨｮｨｺｨｨ 0902000601ｨｪ07 ｪ 05ｨｰ06 ｨｬｨｮ05ｨｹｨｰｨｨ01ｨｨ0902ｨｨ0705ｨｨｨｪｨ 08ｨｪ04ｨｦ 070601010601 ｨｺ 070806ｨ 0502ｨｬｨ ｨｬ, 09ｨｰ0607ｨｴｨｨｨｬ 0702080201 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ02ｨｬ, 000609ｨｮ01ｨ 0809ｨｰ0906ｨｬ ｨｨ 090902ｨｬ 06ｨ ｨｴ0209ｨｰ0906ｨｬ, ｨｰ0802ｨ ｨｮ06ｨｴｨｨｨｬ 09ｨｨ09ｨｰ02ｨｬｨｪ0401 ｨｨ ｨｨｨｪｨｪ0609ｨ 02ｨｨ06ｨｪｨｪ0401 08020302ｨｪｨｨｨｦ. 0201ｨｪｨ ｨｺ06 ｨｪｨｮ03ｨｪ06 0706ｨｪｨｨｨｬｨ ｨｰｨｹ, ﾂｨｰ06 ｨｰｨ ｨｺ0602 ｨｨｨｪｨｪ0609ｨ 02ｨｨｨｨ, ﾂｨｰ06 ｨｬ0603ｨｪ06 ｨｪｨ 0409ｨ ｨｰｨｹ ｨｨｨｪｨｪ0609ｨ 02ｨｨ07ｨｬｨｨ, ｨｺｨ ｨｺ ｨｨ01 ｨｺ05ｨ 0909ｨｨ00ｨｨ02ｨｨ080609ｨ ｨｰｨｹ ｨｨ 060202ｨｪｨｨｨｰｨｹ, ﾂｨｰ06ｨ 04 ｨｪ02 07060101ｨ ｨｰｨｹ0907 0006090502070502ｨｪｨｨ0603 06ｨｰ 05ｨｬ0602ｨｨ06ｨｪｨ 05ｨｹｨｪ0609ｨｰｨｨ 09ｨ ｨｬ060006 05ｨｰ060006 0706ｨｪ07ｨｰｨｨ07. 0308ｨｨ 05ｨｰ06ｨｬ ｨｨｨｬ02ｨｪｨｪ06 0708020109ｨｰｨ 09ｨｨｨｰ0205ｨｨ ｨｨｨｪ01ｨｮ09ｨｰ08ｨｨｨｨ 04ｨ ﾂｨ 09ｨｰｨｮ06 ｨｨ ｨｪ02 0909020001ｨ 06ｨ 0609ｨｪ0609ｨ ｨｪｨｪ06 ｨｨ09070605ｨｹ04ｨｮ06ｨｰ 0706ｨｪ07ｨｰｨｨ02 00ｨｨｨｪｨｪ0609ｨ 02ｨｨ06ｨｪｨｪ0609ｨｰｨｹ03 ｨｺｨ ｨｺ ｨｨｨｪ09ｨｰ08ｨｮｨｬ02ｨｪｨｰ 0708060109ｨｨ0302ｨｪｨｨ07. 03ｨｮｨｰｨｨ 0708060109ｨｨ0302ｨｪｨｨ07 090702080201 ｨｮ ｨｪｨ 09, ｨｺｨ ｨｺ ｨｨ 0906 090902ｨｬ ｨｬｨｨ0802, 0609ｨｰｨ 06ｨｰ0907 090208ｨｹ0204ｨｪ06ｨｦ 070806ｨ 0502ｨｬ06ｨｦ. 00 ｨｰ06 0302 090802ｨｬ07 09ｨｪ02010802ｨｪｨｨ02 ｨｨｨｪｨｪ0609ｨ 02ｨｨ06ｨｪｨｪ0401 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ06050600ｨｨｨｦ, 09 ｨｰ06ｨｬ ﾂｨｨ090502 ｨｨ ｨｪ06090401 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ0401 07080207ｨ 08ｨ ｨｰ0609, ｨｬ060302ｨｰ 0708ｨｨ090601ｨｨｨｰｨｹ ｨｪ02 ｨｰ0605ｨｹｨｺ06 ｨｺ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ06 0706010106010609 ｨｺ 09020102ｨｪｨｨ06 04ｨ ｨ 06050209ｨ ｨｪｨｨｨｦ, 04ｨｪｨ - ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｬｨｮ ｨｮ05ｨｮ ﾂ0302ｨｪｨｨ06 ｨｨ090106010609 0502 ﾂ02ｨｪｨｨ07 ｨｨ ｨｺｨ ﾂ0209ｨｰ09ｨ 03ｨｨ04ｨｪｨｨ, ｨｪ06ｨｨｨｺｨｮ090205ｨｨ ﾂ02ｨｪｨｨ06 04ｨ ｨｰ08ｨ ｨｰ 09ｨ ｨｬ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07. 020202ｨｪｨｺｨ ｨｪ06090401 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ06050600ｨｨｨｦ 09 070604ｨｨ02ｨｨｨｨ ｨｨ01 0106070605ｨｪｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨｰ0208ｨ 070209ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 0202ｨｪｨｪ0609ｨｰｨｨ ｨｨｨｬ02ｨｪｨｪ06 010507 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｨ 0909020006 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07 09 02020506ｨｬ ｪ 05ｨｰ06 ｨｰｨ 09ｨｨ09ｨｰ02ｨｬｨ ｨｺ06060801ｨｨｨｪｨ ｨｰ, 09 08ｨ ｨｬｨｺｨ 01 ｨｺ06ｨｰ060806ｨｦ ｨｨ 0106050302ｨｪ 0609ｨｮｨｴ0209ｨｰ090507ｨｰｨｹ0907 07080602020909 090408ｨ ｨ 06ｨｰｨｺｨｨ ｨｮ0708ｨ 090502ｨｪ ﾂ0209ｨｺｨｨ01 08020302ｨｪｨｨｨｦ. 01ｨ 0302 000609ｨｮ01ｨ 0809ｨｰ0906 09 ｨｪｨ 09ｨｰ0607ｨｴ0202 090802ｨｬ07 ｨｮ0102050702ｨｰ ｨｬｨｪ060006 09ｨｪｨｨｨｬｨ ｨｪｨｨ07 000608ｨｬｨｨ080609ｨ ｨｪｨｨ06 070605ｨｨｨｰｨｨｨｺｨｨ 0904ｨ 0608ｨ 0708ｨｨ0608ｨｨｨｰ02ｨｰ0609 09 06ｨｺｨ 04ｨ ｨｪｨｨｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ06ｨｦ 0706ｨｬ06ｨｴｨｨ ｨｺｨ ｨｺ 0708ｨｨ ｨ 06050202 ｨｰ070302050401 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 090609ｨｰ0607ｨｪｨｨ0701, ｨｰｨ ｨｺ ｨｨ 0708ｨｨ ｨｮ ﾂ02ｨｰ02 ｨｪｨ ｨｨｨ 06050202 090602ｨｨｨ 05ｨｹｨｪ06 ｨｮ0704090502ｨｪｨｪ0401 0008ｨｮ0707 ｨｪｨ 09020502ｨｪｨｨ07. 0201ｨｪｨ ｨｺ06 0607080201020502ｨｪｨｨ02 0708ｨｨ0608ｨｨｨｰ02ｨｰ0609, 000608ｨｬｨｨ080609ｨ ｨｪｨｨ02 09ｨｰｨ ｨｪ01ｨ 08ｨｰ0609 ｨｨ 0904ｨ 0608 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ0401 07080207ｨ 08ｨ ｨｰ0609 ｪ 05ｨｰ06 ｨｰ02 06ｨ 05ｨ 09ｨｰｨｨ 010207ｨｰ0205ｨｹｨｪ0609ｨｰｨｨ, 000102 0904ｨ 0608 0706ｨｪ07ｨｰｨｪ0401 ｨｨ 09060005ｨ 090609ｨ ｨｪｨｪ0401 ｨｺ08ｨｨｨｰ0208ｨｨ0209 09ｨｰｨ ｨｪ0609ｨｨｨｰ0907 ｨｺ08ｨｨｨｰｨｨ ﾂ0209ｨｺｨｨｨｬ 00ｨ ｨｺｨｰ060806ｨｬ 08ｨ 0408ｨ ｨ 06ｨｰｨｺｨｨ 09ｨｨ09ｨｰ02ｨｬｨｪ0401 08020302ｨｪｨｨｨｦ 04ｨ 01ｨ ﾂ, 09ｨｰ0607ｨｴｨｨ01 0702080201 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ02ｨｬ. 04060909ｨｨｨｦ09ｨｺ0602 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ02 09 ｨｰ02 ﾂ02ｨｪｨｨ02 070609050201ｨｪｨｨ01 0502ｨｰ 07060109020800ｨ 02ｨｰ0907 090208ｨｹ0204ｨｪ04ｨｬ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07ｨｬ, ｨｪｨ 0708ｨ 090502ｨｪｨｪ04ｨｬ ｨｪｨ 07020802010601 06ｨｰ 0102ｨｺ05ｨ 08ｨ ｨｰｨｨ09ｨｪ0401 ｨｰ02ｨｪ0102ｨｪ02ｨｨｨｦ ｨｺ ｨ 06050202 0708ｨ 00ｨｬｨ ｨｰｨｨ ﾂｨｪ04ｨｬ, 090409020302ｨｪｨｪ04ｨｬ 08020302ｨｪｨｨ07ｨｬ, 0609ｨｪ0609ｨ ｨｪｨｪ04ｨｬ ｨｪｨ ｨ 06050202 09ｨｨ09ｨｰ02ｨｬｨｪ06ｨｦ ｨｨ01 05ｨｺ09070208ｨｰｨｨ0402 ｨｨ 00ｨｨｨｪｨ ｨｪ09060906ｨｦ 07080608ｨ ｨ 06ｨｰｨｺ02. 030609050201ｨｪｨｨ02 04ｨ ｨｺ06ｨｪ0601ｨ ｨｰ0205ｨｹｨｪ0402 ｨｨ ｨｪ0608ｨｬｨ ｨｰｨｨ09ｨｪ0402 ｨｪ0609060909020102ｨｪｨｨ07, 0907060906ｨ 09ｨｰ09ｨｮ06ｨｴｨｨ02 070609040302ｨｪｨｨ06 09ｨｨ09ｨｰ02ｨｬｨｪ0609ｨｰｨｨ, 06ｨ ｨｲ02ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 0708ｨｨｨｪ02ｨｨ070609 0708ｨｨｨｪ07ｨｰｨｨ07 08020302ｨｪｨｨｨｦ, 0706090502010609ｨ ｨｰ0205ｨｹｨｪ06ｨｦ 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨｪ06ｨｦ 0702080209ｨｰ0806ｨｦｨｺ02 09 060800ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ 090902ｨｦ 09ｨｨ09ｨｰ02ｨｬ04 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07, ｨｰｨ ｨｺ0302 ｨｪｨ 0305ｨｨ 06ｨｰ08ｨ 0302ｨｪｨｨ02 09 01ｨ ｨｪｨｪ06ｨｬ ｨｪ06ｨｬ020802 03ｨｮ08ｨｪｨ 05ｨ. 0906 ﾂｨｮ 0706030205ｨ ｨｰｨｹ 080201ｨ ｨｺ02ｨｨｨｨ 03ｨｮ08ｨｪｨ 05ｨ 00000201ｨｨ02ｨｨｨｪ09ｨｺｨｨ02 ｨｰ0201ｨｪ06050600ｨｨｨｨ. 020202ｨｪｨｺｨ ｨｨ 0904ｨ 060803 09060108ｨ ｨｪｨｨｨｰｨｹ ｨｪｨ 020006 09ｨｰ08ｨ ｨｪｨｨ02ｨ 01 ｨ ｨｺｨｰｨｮｨ 05ｨｹｨｪ0609ｨｰｨｹ, 06ｨ ｨｲ02ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨ ｨｪ0204ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｹ 07ｨｮｨ 05ｨｨｨｺｨｮ02ｨｬ0401 ｨｬｨ ｨｰ0208ｨｨｨ 050609, ｨｪ02 04ｨ ｨ 0409ｨ 07 06 ｨｺ0802ｨ ｨｰｨｨ09ｨｪ0609ｨｰｨｨ 09 000608ｨｬ02 ｨｨ01 070601ｨ ﾂｨｨ. 3 05 ｨｮ09ｨ 0302ｨｪｨｨ02ｨｬ, 02. 02. 00ｨｨ01ｨ ｨｦ050609ｨ 01ｨｨ0802ｨｺｨｰ0608 020207ｨ 08ｨｰｨ ｨｬ02ｨｪｨｰｨ 08ｨ 0409ｨｨｨｰｨｨ07 00ｨ 08ｨｬｨ 020209ｨｰｨｨ ﾂ0209ｨｺ060006 0804ｨｪｨｺｨ ｨｨ 0804ｨｪｨｺｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ06ｨｦ ｨｰ0201ｨｪｨｨｨｺｨｨ 00ｨｨｨｪｨｨ09ｨｰ020809ｨｰ09ｨ 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07 ｨｨ 090602ｨｨｨ 05ｨｹｨｪ060006 08ｨ 0409ｨｨｨｰｨｨ07 04060909ｨｨｨｦ09ｨｺ06ｨｦ 0802010208ｨ 02ｨｨｨｨ, ｨｺｨ ｨｪ01. ｨｬ0201. ｨｪｨ ｨｮｨｺ
130003020600060105080603 06030901020902010606 020003010808 06 0004090204 01 1 2011 0209050204 0102000205060307 4 0209050204 0102000205060307 0308020105ｨ 00ｨ 02ｨｬ 00ｨ 0302ｨｬｨｮ 09ｨｪｨｨｨｬｨ ｨｪｨｨ06 06ｨ 040608 ｨｨ09ｨｰ06 ﾂｨｪｨｨｨｺ0609 ｨｨｨｪ000608ｨｬｨ 02ｨｨｨｨ 09 06ｨ 05ｨ 09ｨｰｨｨ 060202ｨｪｨｺｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ06050600ｨｨｨｦ, ｨｪｨ ｨｮ ﾂｨｪ0401 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ, ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ01 0802ｨｺ06ｨｬ02ｨｪ01ｨ 02ｨｨｨｦ 0706 08ｨ 0405ｨｨ ﾂｨｪ04ｨｬ ｨｪｨ 0708ｨ 090502ｨｪｨｨ07ｨｬ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ06ｨｦ 0708ｨ ｨｺｨｰｨｨｨｺｨｨ, ｨｰｨ ｨｺｨｨｨｬ, ｨｺｨ ｨｺ ｨｺｨ 0801ｨｨ06050600ｨｨ07, ｨｪ02000806050600ｨｨ07, 07ｨｮ05ｨｹｨｬ06ｨｪ06050600ｨｨ07, 06ｨｪｨｺ06050600ｨｨ07 ｨｨ 05ｨｪ0106ｨｺ08ｨｨｨｪ06050600ｨｨ07, ｨ ｨｰｨ ｨｺ0302 ｨｪ06090609ｨｰｨｨ 09 06ｨ 05ｨ 09ｨｰｨｨ ｨｮ0708ｨ 090502ｨｪｨｨ07 ｨｨ 080200ｨｮ05ｨｨ080609ｨ ｨｪｨｨ07 09ｨｨ09ｨｰ02ｨｬ04 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07. 020003010808 06030901020902010607 00 050204080002020904080103010606 1 71 7 NICE ｨｪ02 0802ｨｺ06ｨｬ02ｨｪ010609ｨ 05 ｨｨ09070605ｨｹ040609ｨ ｨｰｨｹ ｨ 0209ｨ 02ｨｨ04ｨｮｨｬｨ ｨ 09 ｨｺ06ｨｬｨ ｨｨｨｪｨ 02ｨｨｨｨ 09 06ｨｺ09ｨ 05ｨｨ0705ｨ ｨｰｨｨｨｪ06ｨｬ, 5-00ｨｰ0608ｨｮ08ｨ 02ｨｨ0506ｨｬ + 0502ｨｦｨｺ06090608ｨｨｨｪ06ｨｬ ｨｨ05ｨｨ ｨｺｨ 070202ｨｨｨｰｨ ｨ ｨｨｨｪ06ｨｬ ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 ｨｬ02ｨｰｨ 09ｨｰｨ 04ｨｨ08ｨｮ06ｨｴｨｨｨｬ 08ｨ ｨｺ06ｨｬ ｨｰ060509ｨｰ060006 ｨｺｨｨ0302 ﾂｨｪｨｨｨｺｨ. 00 09070202ｨｨｨ 05ｨｹｨｪ06 08ｨ 0408ｨ ｨ 06ｨｰｨ ｨｪｨｪ06ｨｬ NICE 08ｨｮｨｺ0609060109ｨｰ0902 0706 060202ｨｪｨｺ02 ｨｰ0201ｨｪ06050600ｨｨｨｦ, 0708ｨｨｨｬ02ｨｪ0706ｨｴｨｨ010907 ｨｮ ｨｮｨｬｨｨ08ｨ 06ｨｴｨｨ01 07ｨ 02ｨｨ02ｨｪｨｰ0609 (00End of life guideline03), ｨｮｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨｺ 09ｨｬ0203ｨ ｨｰ0205ｨｹ09ｨｰ09ｨ ｨｬ, 07080601050209ｨ 06ｨｴｨｨｨｬ 03ｨｨ04ｨｪｨｹ ｨ 0204ｨｪｨ 010203ｨｪ06 ｨ 0605ｨｹｨｪ0401 05060102ｨｦ, 0708ｨｨｨｬ02ｨｪ0706ｨｰ0907 ｨｬ02ｨｪ0202 030209ｨｰｨｺｨｨ02 ｨｺ08ｨｨｨｰ0208ｨｨｨｨ 060202ｨｪｨｺｨｨ 090606ｨｰｨｪ060302ｨｪｨｨ07 0004ｨ ｨｰ08ｨ ｨｰ04/05000002ｨｺｨｰ03, ﾂ02ｨｬ ｨｺ06 090902ｨｬ 0609ｨｰｨ 05ｨｹｨｪ04ｨｬ ｨｬ02ｨｰ0601ｨ ｨｬ 0502 ﾂ02ｨｪｨｨ07. 0201ｨｪｨ ｨｺ06 05ｨｺ09070208ｨｰ04 04ｨ 0709050706ｨｰ, ﾂｨｰ06 070609ｨｺ0605ｨｹｨｺｨｮ 090606ｨｰｨｪ060302ｨｪｨｨ02 0202ｨｪ04 ｨｨ 0106070605ｨｪｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ 070605ｨｹ0404 06ｨｰ 09ｨｺ0506 ﾂ02ｨｪｨｨ07 ｨ 0209ｨ 02ｨｨ04ｨｮｨｬｨ ｨ ｨ 09 090102ｨｬｨｮ ｨｺ06ｨｬｨ ｨｨｨｪｨｨ080609ｨ ｨｪｨｪ06ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ ｨｮ ｨ 0605ｨｹｨｪ0401 09 ｨｬ02ｨｰｨ 09ｨｰｨ 04ｨｨ08ｨｮ06ｨｴｨｨｨｬ ｨｺ0605060802ｨｺｨｰｨ 05ｨｹｨｪ04ｨｬ 08ｨ ｨｺ06ｨｬ 090902 0302 0709050702ｨｰ0907 ｨｪ02ｨ 05ｨ 00060708ｨｨ07ｨｰｨｪ04ｨｬ, 020006 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ02 0706 01ｨ ｨｪｨｪ06ｨｬｨｮ 0706ｨｺｨ 04ｨ ｨｪｨｨ06 09 01ｨ 02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ 0905ｨｮ03ｨ 02 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07 08ｨｪ0005ｨｨｨｨ ｨｨ 070505ｨｹ09ｨ ｨｪ02 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ 060106ｨ 0802ｨｪ06. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: NICE (http://www.nice.org.uk/ta212) 0507ｨｨ0906ｨｺ 0906ｨｺ08ｨ ｨｴ02ｨｪｨｨｨｦ ACC ｪ 08ｨｬ0208ｨｨｨｺｨ ｨｪ09ｨｺｨ 07 ｨｺ0605050200ｨｨ07 ｨｺｨ 0801ｨｨ060506000609; ACA ｪ 08ｨｬ0208ｨｨｨｺｨ ｨｪ09ｨｺｨ 07 ｨｺｨ 0801ｨｨ06050600ｨｨ ﾂ0209ｨｺｨ 07 ｨ 09090602ｨｨｨ 02ｨｨ07; AHRQ ｪ 080002ｨｪｨｰ09ｨｰ0906 0706 ｨｨ09090502010609ｨ ｨｪｨｨ07ｨｬ ｨｨ 060202ｨｪｨｺ02 ｨｺｨ ﾂ0209ｨｰ09ｨ 09 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨｨｨ 050108; CADTH ｪ 08ｨ ｨｪｨ 0109ｨｺ0602 ｨ 0002ｨｪｨｰ09ｨｰ0906 0706 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ04ｨｬ 07080207ｨ 08ｨ ｨｰｨ ｨｬ ｨｨ ｨｰ0201ｨｪ06050600ｨｨ07ｨｬ 09 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨｨｨ; EASD ｪ 030908060702ｨｦ09ｨｺｨ 07 ｨ 09090602ｨｨｨ 02ｨｨ07 0706 ｨｨ04ｨｮ ﾂ02ｨｪｨｨ06 01ｨｨｨ ｨ 02ｨｰｨ ; egfr ｪ 0802020207ｨｰ0608 ｨｺ 0507ｨｨ010208ｨｬｨ 05ｨｹｨｪ06ｨｬｨｮ 00ｨ ｨｺｨｰ0608ｨｮ 080609ｨｰｨ ; FDA ｪ 070708ｨ 090502ｨｪｨｨ02 0706 ｨｪｨ 01040608ｨｮ 04ｨ 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ04ｨｬｨｨ 07080207ｨ 08ｨ ｨｰｨ ｨｬｨｨ ｨｨ 07ｨｨｨｴ020904ｨｬｨｨ 07080601ｨｮｨｺｨｰｨ ｨｬｨｨ 050108; HAS ｪ 01ｨ 02ｨｨ06ｨｪｨ 05ｨｹｨｪ0602 ｨ 0002ｨｪｨｰ09ｨｰ0906 0706 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ06 0808ｨ ｨｪ02ｨｨｨｨ; IQWiG ｪ 06ｨｪ09ｨｰｨｨｨｰｨｮｨｰ ｨｺｨ ﾂ0209ｨｰ09ｨ ｨｨ 05ｨｺ06ｨｪ06ｨｬｨｨ ﾂ0209ｨｺ06ｨｦ 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07 010208ｨｬｨ ｨｪｨｨｨｨ; NICE ｪ 01ｨ 02ｨｨ06ｨｪｨ 05ｨｹｨｪ04ｨｦ ｨｨｨｪ09ｨｰｨｨｨｰｨｮｨｰ 040106080609ｨｹ07 ｨｨ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ060006 09060902080302ｨｪ09ｨｰ090609ｨ ｨｪｨｨ07 000205ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨｨｨ; SCAI ｪ 02ｨ ｨｴ0209ｨｰ0906 0902080102 ﾂｨｪ06-090609ｨｮ01ｨｨ09ｨｰ0401 09ｨｬ0203ｨ ｨｰ0205ｨｹ09ｨｰ09 ｨｨ ｨ ｨｪ00ｨｨ060008ｨ 00ｨｨｨｨ 050108; 0801 ｪ ｨ 08ｨｰ0208ｨｨｨ 05ｨｹｨｪｨ 07 00ｨｨ070208ｨｰ02ｨｪ04ｨｨ07; 0802 ｪ ｨ 08ｨｰ0208ｨｨｨ 05ｨｹｨｪ0602 01ｨ 090502ｨｪｨｨ02; 1 71 7 06000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 070806ｨ ｨｨ06ｨｰｨｨｨｺ0609 09 0502 ﾂ02ｨｪｨｨｨｨ 0609ｨｰ0806ｨｦ 01ｨｨｨ 0802ｨｨ 070601ｨｰ090208030102ｨｪｨ 0806ｨｺ08ｨ ｨｪ060909ｨｺｨｨｨｬ 09ｨｨ09ｨｰ02ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｨｨｬ 06ｨ 04060806ｨｬ. 02ｨ 06ｨ ｨｴ02ｨｪｨｪ0402 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 63 08ｨ ｨｪ0106ｨｬｨｨ04ｨｨ080609ｨ ｨｪｨｪ0401 ｨｨ ｨｺ09ｨ 04ｨｨ-08ｨ ｨｪ0106ｨｬｨｨ04ｨｨ080609ｨ ｨｪｨｪ0401 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ, 060109ｨ ｨｰｨｨ0903ｨｨ01 09 06ｨ ｨｴ02ｨｦ 09050603ｨｪ0609ｨｰｨｨ ｨ 06050202 8000 07ｨ 02ｨｨ02ｨｪｨｰ0609 (09 0609ｨｪ0609ｨｪ06ｨｬ 0102ｨｰ02ｨｦ), 0706ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ06 070601 0905ｨｨ07ｨｪｨｨ02ｨｬ 070806ｨ ｨｨ06ｨｰｨｨｨｺ0609 ｨｨ040502 ﾂ02ｨｪｨｨ02 ｨｪｨ 09ｨｰｨｮ07ｨ 02ｨｰ ｨ 0409ｨｰ080202. 00 ﾂｨ 09ｨｰｨｨ ｨｨ09090502010609ｨ ｨｪｨｨｨｦ 0906ｨｺ08ｨ ｨｴｨ 05ｨ 09ｨｹ 0105ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ 01ｨｨｨ 0802ｨｨ (09 09080201ｨｪ02ｨｬ ｨｪｨ 0601ｨｨｨｪ 0102ｨｪｨｹ), 09 0108ｨｮ00ｨｨ01 08ｨ ｨ 06ｨｰｨ 01 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ06 09ｨｪｨｨ03ｨ 05ｨ 09ｨｹ 01060507 ｨ 0605ｨｹｨｪ0401, ｨｮ ｨｺ06ｨｰ06080401 01ｨｨｨ 080207 09060108ｨ ｨｪ0705ｨ 09ｨｹ ｨｪｨ ﾂ02ｨｰ090208ｨｰ0402 09ｨｮｨｰｨｺｨｨ ｨｨ 0706040302. 0209ｨｰｨ 02ｨｰ0907 ｨｪ02 0709ｨｪ04ｨｬ, ｨｪｨ 09ｨｺ0605ｨｹｨｺ06 06ｨｰ05ｨｨ ﾂｨ 06ｨｰ0907 0108ｨｮ00 06ｨｰ 0108ｨｮ00ｨ 08ｨ 04ｨｪ0402 07080207ｨ 08ｨ ｨｰ04, 090601020803ｨ ｨｴｨｨ02 0706050204ｨｪ0402 ｨ ｨ ｨｺｨｰ0208ｨｨｨｨ. 0809ｨｰ060804 0108ｨｮ00060006 0806ｨｺ08ｨ ｨｪ060909ｨｺ060006 09ｨｨ09ｨｰ02ｨｬｨ ｨｰｨｨ- ﾂ0209ｨｺ060006 06ｨ 040608ｨ, ｨｨ04ｨｮ ﾂｨ 0903ｨｨ02 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 070806ｨ ｨｨ06ｨｰｨｨｨｺ0609 0708ｨｨ 07020809ｨｨ09ｨｰｨｨ08ｨｮ06ｨｴ02ｨｦ 01ｨｨｨ 080202 ｨｮ 0102ｨｰ02ｨｦ, 0708ｨｨ0305ｨｨ ｨｺ 04ｨ ｨｺ0506 ﾂ02ｨｪｨｨ06, ﾂｨｰ06 09 05ｨｰ06ｨｦ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ 09ｨｨｨｰｨｮｨ 02ｨｨｨｨ 0609ｨｰｨ 02ｨｰ0907 02ｨｴ02 ｨｬｨｪ060006 ｨｪ020607080201020502ｨｪｨｪ060006, 0106ｨｰ07 ｨｨｨｬ0206ｨｴｨｨ020907 0909020102ｨｪｨｨ07 0706040906050706ｨｰ 070802010706050603ｨｨｨｰｨｹ, ﾂｨｰ06 070806ｨ ｨｨ06ｨｰｨｨｨｺｨｨ ｨｨ 09 05ｨｰ06ｨｬ 0905ｨｮ ﾂｨ 02 ｨｬ0600ｨｮｨｰ ｨ 04ｨｰｨｹ 0706050204ｨｪ04. 0201ｨｪ06090802ｨｬ02ｨｪｨｪ06 ｨｬ02ｨｰｨ -ｨ ｨｪｨ 05ｨｨ04 10 040806 09 0705ｨ 0202ｨ 06-ｨｺ06ｨｪｨｰ08060502ｨｬ ｨｨ 06090502070502ｨｪｨｨ02ｨｬ, 0904070605ｨｪ02ｨｪｨｪ04ｨｦ 09 050108, 070601ｨｰ09020801ｨｨ05 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 070806ｨ ｨｨ06ｨｰｨｨｨｺ0609, 090601020803ｨ ｨｴｨｨ01 Lactobacillus, 010507 07080600ｨｨ05ｨ ｨｺｨｰｨｨｨｺｨｨ ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺ-ｨ 09090602ｨｨｨｨ080609ｨ ｨｪｨｪ06ｨｦ 01ｨｨｨ 0802ｨｨ ｨｮ 0904080609050401. 06ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 0601ｨｪｨ ｨｨ04 ｨｰ0201ｨｪ06050600ｨｨｨｦ, 03ｨｨ0806ｨｺ06 ｨｨ09070605ｨｹ04ｨｮ06ｨｴｨｨ010907 09 06ｨｰ02 ﾂ0209ｨｰ0902ｨｪｨｪ06ｨｦ 0708ｨ ｨｺｨｰｨｨｨｺ02, ｨｰ02070208ｨｹ 09ｨｰｨ ｨｪ0609ｨｨｨｰ0907 ｨｪｨ ｨｮ ﾂｨｪ06 06ｨ 0609ｨｪ0609ｨ ｨｪｨｪ06ｨｦ. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: The Cochrane Library (http://www2.cochrane.org/ reviews/en/ab003048.html; http://www2.cochrane.org/reviews/ en/ab007401.html); Pharmacotherapy 2010;Feb;30(2):119ｨC126 1 71 7 HAS 07080609020506 ｨｬ02ｨｰｨ -ｨ ｨｪｨ 05ｨｨ04 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ, 0908ｨ 09ｨｪｨｨ09ｨ 06ｨｴｨｨ01 01ｨｨｨ 00ｨｪ0609ｨｰｨｨ ﾂ0209ｨｺｨｮ06 0202ｨｪｨｪ0609ｨｰｨｹ 09ｨｨ08ｨｰｨｮｨ 05ｨｹｨｪ06ｨｦ ｨｺ060506ｨｪ0609ｨｺ0607ｨｨｨｨ ｨｨ 06ｨ 04 ﾂｨｪ06ｨｦ ｨｺ060506ｨｪ0609ｨｺ0607ｨｨｨｨ 09 0909020102ｨｪｨｨ02ｨｬ ｨｺ060506ｨｪ0609ｨｺ0607ｨ 09 070806090902ｨｰ ｨｺｨｨ0302 ﾂｨｪｨｨｨｺｨ 010507 090407090502ｨｪｨｨ07 070605ｨｨ070609 ｨｨ 01ｨｨｨ 00ｨｪ0609ｨｰｨｨｨｺｨｨ ｨｺ0605060802ｨｺｨｰｨ 05ｨｹｨｪ060006 08ｨ ｨｺｨ, 09 020205ｨｹ06 08ｨ 0408ｨ ｨ 06ｨｰｨｺｨｨ 0802ｨｺ06ｨｬ02ｨｪ01ｨ 02ｨｨｨｦ 0706 060705ｨ ｨｰ02 09ｨｨ08ｨｰｨｮｨ 05ｨｹｨｪ06ｨｦ ｨｺ060506ｨｪ0609ｨｺ0607ｨｨｨｨ ｨｨ04 0908020109ｨｰ09 06ｨ ｨｴ0209ｨｰ0902ｨｪｨｪ060006 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07. 02ｨ 06ｨ ｨｴ02ｨｪ04 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 24 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ, 060109ｨ ｨｰｨｨ0903ｨｨ01 ｨ 06050202 7000 07ｨ 02ｨｨ02ｨｪｨｰ0609. ﾁｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ ｨｨ 09070202ｨｨ00ｨｨ ﾂｨｪ0609ｨｰｨｹ 06ｨ 04 ﾂｨｪ06ｨｦ ｨｺ060506ｨｪ0609ｨｺ0607ｨｨｨｨ 090902 0302 0106 ｪ 0005ｨｨｨｺ02ｨｬｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｨｨｪ0102ｨｺ09; 060905 ｪ ｨｨ0302ｨｬｨｨ ﾂ0209ｨｺｨ 07 ｨ 06050204ｨｪｨｹ 0902080102ｨ ; 060006 ｪ ｨｨｨｪ0102ｨｺ09 ｨｬｨ 090904 ｨｰ0205ｨ ; 0904 ｪ 05020904ｨｦ 030205ｨｮ0106 ﾂ02ｨｺ; 09030103 ｪ 05ｨｨ0706070806ｨｰ02ｨｨ0104 ｨｪｨｨ04ｨｺ06ｨｦ 070506ｨｰｨｪ0609ｨｰｨｨ; 000406 ｪ ｨｬｨ 00ｨｪｨｨｨｰｨｪ06-08020406ｨｪｨ ｨｪ09ｨｪｨ 07 ｨｰ06ｨｬ060008ｨ 00ｨｨ07; 020600 ｪ 0609ｨｰ0804ｨｦ ｨｨｨｪ00ｨ 08ｨｺｨｰ ｨｬｨｨ06ｨｺｨ 0801ｨ ; 02010008 ｪ 0609ｨｰ080602 ｨｪｨ 08ｨｮ0302ｨｪｨｨ02 ｨｬ0604000609060006 ｨｺ0806090606ｨ 08ｨ ｨｴ02ｨｪｨｨ07; 0204 ｪ 06ｨｰｨｪ060302ｨｪｨｨ02 08ｨｨ09ｨｺ0609; 040806 ｪ 08ｨ ｨｪ0106ｨｬｨｨ04ｨｨ080609ｨ ｨｪｨｪ0602 ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ02ｨｬ0602 ｨｨ090704ｨｰｨ ｨｪｨｨ02; 0502 ｪ 09ｨ 01ｨ 08ｨｪ04ｨｦ 01ｨｨｨ ｨ 02ｨｰ; 050904 ｪ 0902080102 ﾂｨｪ06-05000006 ﾂｨｪｨ 07 0802ｨ ｨｪｨｨｨｬｨ 02ｨｨ07; 050003 ｪ 09ｨｺ0608ｨ 07 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨ 07 0706ｨｬ06ｨｴｨｹ; 050403 ｪ 05-0802ｨ ｨｺｨｰｨｨ09ｨｪ04ｨｦ 070806ｨｰ02ｨｨｨｪ; 050505 ｪ 0902080102 ﾂｨｪ06-090609ｨｮ01ｨｨ09ｨｰ0402 04ｨ ｨ 06050209ｨ ｨｪｨｨ07; 050505 ｪ 0902080102 ﾂｨｪ06-090609ｨｮ01ｨｨ09ｨｰｨ 07 09ｨｨ09ｨｰ02ｨｬｨ ; 09020909 ｪ 010806ｨｪｨｨ ﾂ0209ｨｺｨ 07 06ｨ 09ｨｰ08ｨｮｨｺｨｰｨｨ09ｨｪｨ 07 ｨ 06050204ｨｪｨｹ 050000ｨｺｨｨ01; 090301 ｪ 010806ｨｪｨｨ ﾂ0209ｨｺｨ 07 0706 ﾂ02 ﾂｨｪｨ 07 ｨｪ02010609ｨｰｨ ｨｰ06 ﾂｨｪ0609ｨｰｨｹ; 090501 ｪ 010806ｨｪｨｨ ﾂ0209ｨｺｨ 07 0902080102 ﾂｨｪｨ 07 ｨｪ02010609ｨｰｨ ｨｰ06 ﾂｨｪ0609ｨｰｨｹ.
1309ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ06 09040302, ﾂ02ｨｬ 09ｨｨ08ｨｰｨｮｨ 05ｨｹｨｪ06ｨｦ, ｨｪ0204ｨ 09ｨｨ09ｨｨｨｬ06 06ｨｰ 08ｨ 04ｨｬ0208ｨ 070608ｨ 0302ｨｪｨｨ07 0905ｨｨ04ｨｨ09ｨｰ06ｨｦ ｨｺｨｨ0302 ﾂｨｪｨｨｨｺｨ. 080002ｨｪｨｰ09ｨｰ0906 0708ｨｨ030506 ｨｺ 04ｨ ｨｺ0506 ﾂ02ｨｪｨｨ06, ﾂｨｰ06 09ｨｨ08ｨｰｨｮｨ 05ｨｹｨｪｨ 07 ｨｺ060506ｨｪ0609ｨｺ0607ｨｨ07 0706ｨｺｨ ｨｪ02 ｨｬ060302ｨｰ 04ｨ ｨｬ02ｨｪｨｨｨｰｨｹ 06ｨ 04 ﾂｨｪｨｮ06 ｨｨ 0802ｨｺ06ｨｬ02ｨｪ01ｨｮ02ｨｰ0907 ｨｰ0605ｨｹｨｺ06 0708ｨｨ ｨｪ02090604ｨｬ0603ｨｪ0609ｨｰｨｨ 070806090209ｨｰｨｨ 070605ｨｪ0602 06ｨ 090502010609ｨ ｨｪｨｨ02 ｨｰ060509ｨｰ060006 ｨｺｨｨ0302 ﾂｨｪｨｨｨｺｨ ｨｺ060506ｨｪ0609ｨｺ060706ｨｬ 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬ 09 090607ｨｮｨｰ09ｨｰ09ｨｮ06ｨｴｨｨｨｬｨｨ 04ｨ ｨ 06050209ｨ ｨｪｨｨ07ｨｬｨｨ, 06ｨｰｨｺｨ 04ｨ 0903ｨｨｨｬ0907 06ｨｰ 06ｨ 04 ﾂｨｪ06ｨｦ ｨｺ060506ｨｪ0609ｨｺ0607ｨｨｨｨ. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: HAS (http://www.has-sante.fr/portail/ upload/docs/application/pdf/ 2010-109/abstract_virtual_colonoscopy_meta-analysis_of_diagnostic_accuracy_indications_and_conditions_of_use_-_version_anglaise.pdf) 1 71 7 030609ｨｺ0605ｨｹｨｺｨｮ ｨｬ06ｨ ｨｨ05ｨｹｨｪ0402 ｨｰ0205020006ｨｪ04 070806 ﾂｨｪ06 09060305ｨｨ 09 070609090201ｨｪ0209ｨｪｨｮ06 03ｨｨ04ｨｪｨｹ, 02020502090606ｨ 08ｨ 04ｨｪ06 ｨｨ04ｨｮ ﾂｨｨｨｰｨｹ 090604ｨｬ0603ｨｪ0609ｨｰｨｹ ｨｨ01 0905ｨｨ07ｨｪｨｨ07 ｨｪｨ 0108ｨｮ00ｨｨ02 050502ｨｺｨｰ0806ｨｪｨｪ0402 ｨｮ09ｨｰ0806ｨｦ09ｨｰ09ｨ, ﾂｨｰ06 060906ｨ 02ｨｪｨｪ06 09ｨ 03ｨｪ06 09 ｨｮ09050609ｨｨ0701 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ060006 ｨｮ ﾂ0802030102ｨｪｨｨ07. CADTH 0607ｨｮｨ 05ｨｨｨｺ0609ｨ 0506 06ｨｰ ﾂ00ｨｰ 06ｨ ｨｨｨｬ0206ｨｴｨｨ010907 ｨｪｨ 0902000601ｨｪ0703ｨｪｨｨｨｦ 0102ｨｪｨｹ 0106ｨｺｨ 04ｨ ｨｰ0205ｨｹ09ｨｰ09ｨ 01 0706 05ｨｰ06ｨｦ 070806ｨ 0502ｨｬ02. 05060005ｨ 09ｨｪ06 02ｨｬｨｮ, ｨｬ06ｨ ｨｨ05ｨｹｨｪ0402 ｨｰ0205020006ｨｪ04 ｨｬ0600ｨｮｨｰ 09060401ｨ 09ｨ ｨｰｨｹ 0706ｨｬ0201ｨｨ ｨｬ06ｨｪｨｨｨｰ0608ｨ ｨｬ ｨｨ 0409ｨｮｨｺ060904ｨｬ 09ｨｨ00ｨｪｨ 05ｨｨ04ｨ 02ｨｨ07ｨｬ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｮ09ｨｰ0806ｨｦ09ｨｰ09, ｨｪ06 ｨｨ01 0905ｨｨ07ｨｪｨｨ02 ｨｪｨ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ02 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨｬｨ 05060902080607ｨｰｨｪ06. 01ｨ ｨｨｨ 06050202 02020502090606ｨ 08ｨ 04ｨｪ06 01020803ｨ ｨｰｨｹ ｨｬ06ｨ ｨｨ05ｨｹｨｪ0402 ｨｰ0205020006ｨｪ04 ｨｪｨ 08ｨ 0909ｨｰ0607ｨｪｨｨｨｨ 0601ｨｪ060006 ｨｬ02ｨｰ08ｨ 06ｨｰ 050502ｨｺｨｰ0806ｨｪｨｪ060006 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ060006 06ｨ 0608ｨｮ010609ｨ ｨｪｨｨ07. 0609ｨｰ06 ﾂｨｪｨｨｨｺｨｨ: CADTH (http://www.cadth.ca/media/pdf/ K0282_Cell_Phones_Hospitals.pdf) 1 71 7 02 ﾂ02080201ｨｪ06ｨｦ 0708ｨｨｨｬ0208 ｨｰ060006, ﾂｨｰ06 0008ｨ ｨｬ06ｨｰｨｪ0602 ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨ02 ｨｨｨｬ0206ｨｴｨｨ010907 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ06050600ｨｨｨｦ 0709050702ｨｰ0907 ｨｪ02 ｨｰ0605ｨｹｨｺ06 0907060906ｨ 06ｨｬ ｨ 0608ｨｹｨ 04 04ｨ 040106080609ｨｹ02, ｨｪ06 ｨｨ 05ｨｺ06ｨｪ06ｨｬｨｨ ﾂ0209ｨｺｨｨ 0904000601ｨｪ06, 0708060102ｨｬ06ｨｪ09ｨｰ08ｨｨ080609ｨ ｨｪ 09 000205ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨｨｨ. 05060005ｨ 09ｨｪ06 06ｨｰ ﾂ00ｨｰｨｮ 0806080605020909ｨｺ06ｨｦ ｨｺ0605050200ｨｨｨｨ 01ｨｨ08ｨｮ08000609, ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ0906 0908ｨ ﾂ02ｨｦ, 08ｨ ｨ 06ｨｰｨ 06ｨｴｨｨ01 09 ｨｮ09050609ｨｨ0701 07020809ｨｨ ﾂｨｪ06ｨｦ 0706ｨｬ06ｨｴｨｨ, ｨｪ02 0906ｨ 050601ｨ 06ｨｰ 0802ｨｺ06ｨｬ02ｨｪ01ｨ 02ｨｨｨｨ NICE 0706 0502 ﾂ02ｨｪｨｨ06 0603ｨｨ0802ｨｪｨｨ07 09 0706ｨｬ06ｨｴｨｹ06 ｨｬ02ｨｰ06010609 ｨ ｨ 08ｨｨｨ ｨｰ08ｨｨ ﾂ0209ｨｺ06ｨｦ 01ｨｨ08ｨｮ0800ｨｨｨｨ, ｨｺ06ｨｰ0608ｨ 07 0706ｨｺｨ 04ｨ ｨｪｨ 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬ 09 060006 ｨ 06050202 35 ｨｺ00/ｨｬ 2 ｨｨ ｨ 09090602ｨｨｨｨ080609ｨ ｨｪｨｪ04ｨｬｨｨ 09 ｨｪｨｨｨｬ 04ｨ ｨ 06050209ｨ ｨｪｨｨ07ｨｬｨｨ, ｨｪｨ 0708ｨｨｨｬ0208, 0502 2 ｨｰｨｨ07ｨ ｨｨ05ｨｨ 0801. 030807ｨｬ0402 ｨｮｨ 04ｨｰｨｺｨｨ 06ｨｰ 0603ｨｨ0802ｨｪｨｨ07 ｨｨ 09090704ｨ ｨｪｨｪ0401 09 ｨｪｨｨｨｬ ｨｪ060406050600ｨｨｨｦ 09 000205ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨｨｨ 090609ｨｰｨ 09050706ｨｰ ｨ 06050202 4,3 ｨｬ050801 00ｨｮｨｪｨｰ0609 09ｨｰ020805ｨｨｨｪ000609. 0009020006 070601 ｨｺ08ｨｨｨｰ0208ｨｨｨｨ ｨ ｨ 08ｨｨｨ ｨｰ08ｨｨ ﾂ0209ｨｺ06ｨｦ 01ｨｨ08ｨｮ0800ｨｨｨｨ 07060107ｨ 01ｨ 06ｨｰ 06ｨｺ060506 100 ｨｬ05ｨｪ 03ｨｨｨｰ020502ｨｦ 000205ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨｨｨ. 0004070605ｨｪ02ｨｪｨｨ02 06070208ｨ ｨｰｨｨ09ｨｪ060006 09ｨｬ0203ｨ ｨｰ0205ｨｹ09ｨｰ09ｨ 0106ｨｰ07 ｨ 04 ｨｮ 5 % ｨｨ04 ｨｪｨｨ01 070604090605ｨｨｨｰ 0905ｨｺ06ｨｪ06ｨｬｨｨｨｰｨｹ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 3 0502ｨｰ 382 ｨｬ05ｨｪ 00ｨｮｨｪｨｰ0609, ｨｰ060001ｨ ｨｺｨ ｨｺ 07080609020102ｨｪｨｨ02 06070208ｨ 02ｨｨｨｨ ｨｮ ﾂ02ｨｰ090208ｨｰｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ0609 0905ｨｺ06ｨｪ06ｨｬｨｨｨｰ ｨｮ0302 1,3 ｨｬ050801 00ｨｮｨｪｨｰ0609. 080806ｨｬ02 ｨｰ060006, 0603ｨｨ01ｨ 02ｨｬｨ 07 0904000601ｨ 06ｨｰ 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨ07 ｨｰ08ｨｮ01060907060906ｨ ｨｪ0609ｨｰｨｨ ｨｨ 0906040908ｨ ｨｴ02ｨｪｨｨ07 05060102ｨｦ ｨｪｨ 08ｨ ｨ 06ｨｰｨｮ 090609ｨｰｨ 09ｨｨｨｰ 06ｨｰ 35 0106 150 ｨｬ05ｨｪ 00ｨｮｨｪｨｰ0609. 06ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 01ｨ ｨｪｨｪｨ 07 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨ 07 ｨｰ0201ｨｪ06050600ｨｨ07 06 ﾂ02ｨｪｨｹ ｨ 0409ｨｰ0806 0902ｨ 07 06ｨｺｨｮ07ｨｨｨｰ. 00 0102ｨｦ09ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ 0302 04ｨ 07080603020103ｨｨｨｦ 000601 09 000205ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨｨｨ 0904070605ｨｪ02ｨｪ06 020109ｨ 05ｨｨ 4000 06070208ｨ 02ｨｨｨｦ. 0207ｨｨ09ｨ ｨｪｨｪｨ 07 09ｨｨｨｰｨｮｨ 02ｨｨ07 ｨｨｨｬ0202ｨｰ ｨｬｨｪ060006 06ｨ ｨｴ020006 09 08060909ｨｨｨｦ09ｨｺ06ｨｦ 0102ｨｦ09ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ06, 000102 0708ｨ ｨｺｨｰｨｨｨｺｨ 01ｨｨ08ｨｮ0800ｨｨ- ﾂ0209ｨｺ060006 0502 ﾂ02ｨｪｨｨ07 0603ｨｨ0802ｨｪｨｨ07 08ｨ 0907080609ｨｰ08ｨ ｨｪ02ｨｪｨ 09 02ｨｴ00 ｨｬ02ｨｪｨｹ0302ｨｦ 09ｨｰ020702ｨｪｨｨ ｨｨ 09 07020809ｨｮ06 06 ﾂ02080201ｨｹ ｨｨ09070605ｨｹ04ｨｮ02ｨｰ0907 ｨｬｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪ06 ｨｺ06ｨｪ09020809ｨ ｨｰｨｨ09ｨｪ04ｨｦ 070601010601. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: NICE (http://www.nice.org.uk/ newsroom/news/surgeryfor- ObeseCouldSaveMillions.jsp) 1 71 7 05070202ｨｨｨ 05ｨｨ09ｨｰ04 IQWiG 0607ｨｮｨ 05ｨｨｨｺ0609ｨ 05ｨｨ 09 0908ｨｨｨｰｨ ｨｪ09ｨｺ06ｨｬ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ06ｨｬ 03ｨｮ08ｨｪｨ 0502 09ｨｰｨ ｨｰｨｹｨｨ 06 070806ｨ 0502ｨｬｨ 01 0706ｨｨ09ｨｺｨ 010609ｨｰ06090208ｨｪ06ｨｦ ｨｨｨｪ000608ｨｬｨ 02ｨｨｨｨ 0708ｨｨ 07080609020102ｨｪｨｨｨｨ 060202ｨｪｨｺｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ06050600ｨｨｨｦ ｨｪｨ 0708ｨｨｨｬ020802 ｨ ｨｪｨｰｨｨ01020708020909ｨ ｨｪｨｰｨ 0802ｨ 06ｨｺ0902ｨｰｨｨｨｪｨ. 02ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨ02 ｨｰ0802ｨ 0609ｨ ｨｪｨｨ07 ｨｺ 070806ｨｨ04090601ｨｨｨｰ020507ｨｬ 07080207ｨ 08ｨ ｨｰ0609 09 06ｨ 0704ｨ ｨｰ0205ｨｹｨｪ06ｨｬ 0706080701ｨｺ02 07ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｰｨｹ 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 09090201 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ01 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ 0708ｨｨ090601ｨｨｨｰ ｨｺ 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ04ｨｬ ｨｨ09ｨｺｨ 0302ｨｪｨｨ07ｨｬ 0708ｨｨ 060202ｨｪｨｺ02 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｨ ｨ 02040607ｨ 09ｨｪ0609ｨｰｨｨ ｨｰ0201ｨｪ06050600ｨｨｨｦ. 06ｨ ｨｺ, 09ｨ 03ｨｪｨｮ06 ｨｨｨｪ000608ｨｬｨ 02ｨｨ06 06 0802ｨ 06ｨｺ0902ｨｰｨｨｨｪ02, 090601020803ｨ ｨｴｨｮ060907 09 ｨｪ02 0607ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪｨｪ0401 ｨｪｨｨ000102 06ｨｰ ﾂ02ｨｰｨ 01, 05ｨｺ09070208ｨｰｨ ｨｬ IQWiG ｨｮ01ｨ 050609ｨｹ 070605ｨｮ ﾂｨｨｨｰｨｹ ｨｰ0605ｨｹｨｺ06 070601 01ｨ 090502ｨｪｨｨ02ｨｬ 06ｨ ｨｴ0209ｨｰ0902ｨｪｨｪ0609ｨｰｨｨ. 030905ｨｨ ｨｮ ﾂｨｨｨｰ0409ｨ ｨｰｨｹ 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 09090201, 09 ｨｰ06ｨｬ ﾂｨｨ090502 ｨｪ020607ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪｨｪ0401 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ, 070605ｨｹ04ｨ 06ｨｰ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 0802ｨ 06ｨｺ0902ｨｰｨｨｨｪｨ 0906ｨｺ08ｨ ｨｴｨ 02ｨｰ0907 0901090602 0706 0908ｨ 09ｨｪ02ｨｪｨｨ06 09 06ｨ 06ｨ ｨｴ02ｨｪｨｪ04ｨｬｨｨ 01ｨ ｨｪｨｪ04ｨｬｨｨ ｨｰ0605ｨｹｨｺ06 0607ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪｨｪ0401 08ｨ ｨ 06ｨｰ. 05070202ｨｨｨ 05ｨｨ09ｨｰ04 IQWiG 09 ﾂｨｨｨｰｨ 06ｨｰ, ﾂｨｰ06 05ｨｰ06ｨｰ 060704ｨｰ 0905ｨｮ03ｨｨｨｰ 0609ｨｪ0609ｨ ｨｪｨｨ02ｨｬ 010507 09ｨｪ02010802ｨｪｨｨ07 04ｨ ｨｺ06ｨｪ0601ｨ ｨｰ0205ｨｹｨｪ060006 ｨｰ0802ｨ 0609ｨ ｨｪｨｨ07 07ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｰｨｹ 090902 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ0401 07080207ｨ 08ｨ ｨｰ0609, ｨｪ020502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ0401 ｨｬ02ｨｰ06010609 0502 ﾂ02ｨｪｨｨ07 ｨｨ ｨｨ04010205ｨｨｨｦ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ060006 ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｨ07 ｨｨ 080200ｨｨ09ｨｰ08ｨｨ080609ｨ ｨｰｨｹ 090902 ｨｪｨ ﾂｨ ｨｰ0402 ｨｨ090704ｨｰｨ ｨｪｨｨ07. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: IQWiG (https://www.iqwig.de/ index.1133.en.html); BMJ 2010;341:c4942; BMJ 2010;341:c4737 1 71 7 03060806ｨｦ, ﾂｨｰ06ｨ 04 ｨｰ0201ｨｪ06050600ｨｨ07 04ｨ 08ｨ ｨ 06ｨｰｨ 05ｨ, 010609ｨｰｨ ｨｰ06 ﾂｨｪ06 ｨｪｨ ﾂｨ ｨｰｨｹ 0708ｨ 09ｨｨ05ｨｹｨｪ06 0200 ｨｨ09070605ｨｹ040609ｨ ｨｰｨｹ. 00 050108 07080609020102ｨｪ06 ｨｨ09090502010609ｨ ｨｪｨｨ02, 09ｨｰｨ 09ｨｨ09030202 09090602ｨｦ 020205ｨｹ06 ｨｨ04ｨｮ ﾂｨｨｨｰｨｹ ｨｬ02ｨｰ0601ｨｨｨｺｨｮ ｨ 0608ｨｹｨ 04 09 ｨｺｨｮ0802ｨｪｨｨ02ｨｬ 09 0607080201020500ｨｪｨｪ0401 05ｨｰｨｪｨｨ ﾂ0209ｨｺｨｨ01 0008ｨｮ0707ｨ 01, ｨ ｨｰｨ ｨｺ0302 09080201ｨｨ 05ｨｨ02 09 ｨｪｨｨ04ｨｺｨｨｨｬ 010601060106ｨｬ. 020507 05ｨｰ060006 ｨ 0405ｨｨ 0904ｨ 08ｨ ｨｪ04 ｨｪ0209ｨｺ0605ｨｹｨｺ06 000609ｨｮ01ｨ 0809ｨｰ0902ｨｪｨｪ0401 09ｨｰ06ｨｬｨ ｨｰ06050600ｨｨ ﾂ0209ｨｺｨｨ01 ｨｺ05ｨｨｨｪｨｨｨｺ, 09 ﾂｨ 09ｨｰｨｨ ｨｨ04 ｨｺ06ｨｰ06080401 0908ｨ ﾂｨｨ 0706ｨｬｨｨｨｬ06 090906ｨｨ01 0609ｨｪ0609ｨｪ0401 06ｨ 0704ｨ ｨｪｨｪ0609ｨｰ02ｨｦ ｨｪ02 ｨｰ0605ｨｹｨｺ06 0106070605ｨｪｨｨｨｰ0205ｨｹｨｪ06 070806090601ｨｨ05ｨｨ 08ｨ 04ｨｲ0709ｨｪｨｨｨｰ0205ｨｹｨｪｨｮ06 08ｨ ｨ 06ｨｰｨｮ 06 0908020102 ｨｺｨｮ0802ｨｪｨｨ07, ｨｪ06 ｨｨ 0708ｨｨ ｨｪ0206ｨ 010601ｨｨｨｬ0609ｨｰｨｨ ｨｪｨ 04ｨｪｨ - ﾂｨ 05ｨｨ ｨｬ0201ｨｨｨｺｨ ｨｬ02ｨｪｨｰ0604ｨｪｨｮ06 ｨｰ0208ｨ 07ｨｨ06. ﾁ02080204 7,5 ｨｬ020907020209 ﾂｨ 09ｨｰ06ｨｰｨ 09ｨｰ06ｨｦｨｺ060006 09060401020803ｨ ｨｪｨｨ07 06ｨｰ ｨｺｨｮ0802ｨｪｨｨ07 09080201ｨｨ ｨｰ0201, ｨｺ060006 ｨ ｨｺｨｰｨｨ09ｨｪ06 0502 ﾂｨｨ05ｨｨ 09ｨｰ06ｨｬｨ ｨｰ06050600ｨｨ, ｨ 0405ｨ 09040302, ﾂ02ｨｬ ｨｮ ｨｰ0201, ｨｺｨｰ06 0704ｨｰｨ 050907 ｨ 080609ｨｨｨｰｨｹ ｨｺｨｮ08ｨｨｨｰｨｹ 09ｨ ｨｬ0609ｨｰ0607ｨｰ0205ｨｹｨｪ06: 5,3 ｨｨ 1,6 %, 090606ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06 (p < 0,01). 0609ｨｰ06 ﾂｨｪｨｨｨｺ: Am J Public Health 201;Jul;100(7):1307ｨC11312 07030408000903010603 06 04030107090604020008010603 1 71 7 08ｨｪｨ 05ｨｨ04 58 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ, 07080609020100ｨｪｨｪ0401 09 ｨｪ0209ｨｺ0605ｨｹｨｺｨｨ01 09ｨｰ08ｨ ｨｪｨ 01, 0706ｨｺｨ 04ｨ 05, ﾂｨｰ06 00ｨ 08ｨｬｨ 020209ｨｰｨｨ ﾂ0209ｨｺｨｨ02 ｨｺ06ｨｬ07ｨ ｨｪｨｨｨｨ 0907060906ｨ ｨｪ04 06ｨｺｨ 040409ｨ ｨｰｨｹ 0905ｨｨ07ｨｪｨｨ02 ｨｪｨ ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｨ02 07080207ｨ 08ｨ ｨｰ0609 0908ｨ ﾂｨ ｨｬｨｨ. 0006070802ｨｺｨｨ 04ｨ 07090502ｨｪｨｨ07ｨｬ ｨｬｨｪ0600ｨｨ01 0908ｨ ﾂ02ｨｦ 06 ｨｪ0204ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ ｨｨ01 0904ｨ 0608ｨ, 09 38 08ｨ ｨ 06ｨｰｨ 01 ｨ 040506 0706ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 09 0905ｨｮ ﾂｨ 02 070605ｨｮ ﾂ02ｨｪｨｨ07 ｨｨｨｪ000608ｨｬｨ 02ｨｨｨｨ 06 07080207ｨ 08ｨ ｨｰ02 ｨｪｨ 070807ｨｬｨｮ06 06ｨｰ 070806ｨｨ04090601ｨｨｨｰ020507, 0106ｨｺｨｰ0608 ｨ ｨｮ0102ｨｰ 07080607ｨｨ090409ｨ ｨｰｨｹ 020006 ﾂｨ ｨｴ02. 00 01060102 02ｨｴ00 0601ｨｪ060006 ｨｨ09090502010609ｨ ｨｪｨｨ07, 07080609020100ｨｪｨｪ060006 09 000205ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨｨｨ 09080201ｨｨ 1000 0908ｨ ﾂ02ｨｦ 06ｨ ｨｴ02ｨｦ 0708ｨ ｨｺｨｰｨｨｨｺｨｨ, ｨ 040506 ｨｮ09ｨｰｨ ｨｪ06090502ｨｪ06, ﾂｨｰ06 ｨｰ02, ｨｺｨｰ06 ｨｺ06ｨｪｨｰｨ ｨｺｨｰｨｨ080609ｨ 05 09 0708020109ｨｰｨ 09ｨｨｨｰ020507ｨｬｨｨ 06ｨｰ010205ｨ 07080601ｨ 03 00ｨ 08ｨｬｨ 020209ｨｰｨｨ ﾂ0209ｨｺｨｨ01 ｨｺ06ｨｬ07ｨ ｨｪｨｨｨｦ, 09ｨｺ0506ｨｪｨｪ04 07080607ｨｨ090409ｨ ｨｰｨｹ ｨ 06050202 01060806000609ｨｰ0607ｨｴｨｨ02 07080207ｨ 08ｨ ｨｰ04. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: Reuters (http://www.reuters.com/article/ idustre69j4ax20101020) 1 71 7 04ｨ 09ｨｰ00ｨｰ 09ｨｪｨｨｨｬｨ ｨｪｨｨ02 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ060006 090606ｨ ｨｴ0209ｨｰ09ｨ ｨｺ ｨｰ06ｨｬｨｮ, ﾂｨｰ06 ｨｬｨｪ0600ｨｨ02 ｨｨ09090502010609ｨ ｨｪｨｨ07, 07080609020102ｨｪｨｪ0402 ｨｪｨ ｨ 0605ｨｹ03ｨｨ01 0904ｨ 0608ｨｺｨ 01 09 0102ｨｦ09ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ 09040709050706ｨｰ ｨｬｨ 0502ｨｪｨｹｨｺｨｨｨｦ 0706 08ｨ 04ｨｬ0208ｨ ｨｬ 05000002ｨｺｨｰ, 0106ｨｺｨ 040409ｨ 07 ｨｰｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, ﾂｨｰ06 ｨｨ0909050201ｨｮ02ｨｬ04ｨｦ 07080207ｨ 08ｨ ｨｰ ｨｪ02 09ｨｰ0605ｨｹ 05000002ｨｺｨｰｨｨ0902ｨｪ, ｨｺｨ ｨｺ 0106ｨｰ02050609ｨｹ ｨ 04 ｨｺ05ｨｨｨｪｨｨ02ｨｨ09ｨｰｨ ｨｬ, 090408ｨ 03ｨ 06ｨｴｨｨｨｬ ｨｨｨｪｨｰ0208020904 070806ｨｨ04090601ｨｨｨｰ020502ｨｦ. 0207ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪｨ 09ｨｰｨ ｨｰｨｹ07, 0706090907ｨｴ00ｨｪｨｪｨ 07 ｨ ｨｪｨ 05ｨｨ04ｨｮ 01ｨ ｨｪｨｪ06ｨｦ 070806ｨ 0502ｨｬ04 ｨｨ ｨｬ02ｨｰ0601ｨ ｨｬ 0200 08020302ｨｪｨｨ07, ｨｨ04 ｨｺ06ｨｰ060806ｨｦ 09050201ｨｮ02ｨｰ, ﾂｨｰ06 090102ｨｬｨ 0708ｨｨｨｪ07ｨｰｨｨ07 08020302ｨｪｨｨ07 06 08ｨ 0408020302ｨｪｨｨｨｨ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 07080207ｨ 08ｨ ｨｰｨ 010607ｨｮ09ｨｺｨ 02ｨｰ ｨｪ02ｨ 0605ｨｹ03ｨｨ02 04ｨｪｨ ﾂ02ｨｪｨｨ07 ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ07 08ｨｨ09ｨｺｨ. 06ｨｪｨ ﾂ02 000609060807, 010607ｨｮ09ｨｰｨｨｨｬ04ｨｦ 08ｨ 04ｨｬ0208 05000002ｨｺｨｰｨ, 0102ｨｬ06ｨｪ09ｨｰ08ｨｨ08ｨｮ06ｨｴｨｨｨｦ 070802ｨｨｨｬｨｮｨｴ0209ｨｰ09ｨ 07080207ｨ 08ｨ ｨｰｨ, 0106050302ｨｪ ｨ 04ｨｰｨｹ ｨｮ090205ｨｨ ﾂ02ｨｪ. 080806ｨｬ02 ｨｰ060006, ｨｪ02 09050201ｨｮ02ｨｰ 090900 09ｨｪｨｨｨｬｨ ｨｪｨｨ02 ｨｮ01020507ｨｰｨｹ 0706ｨｺｨ 04ｨ ｨｰ020506 0902080607ｨｰｨｪ0609ｨｰｨｨ 0603ｨｨｨ ｨｺｨｨ, ｨ 06ｨ 08ｨ ｨｴｨ ｨｰｨｹ 09ｨｪｨｨｨｬｨ ｨｪｨｨ02 ｨｪｨ 070605ｨｮ ﾂ02ｨｪｨｪ04ｨｦ 0106090208ｨｨｨｰ0205ｨｹｨｪ04ｨｦ ｨｨｨｪｨｰ020809ｨ 05, ｨｺ06ｨｰ060804ｨｦ 0709050702ｨｰ0907 ｨ 06050202 09ｨ 03ｨｪ04ｨｬ, ｨｨ ｨｪｨｨ 09 ｨｺ0602ｨｬ 0905ｨｮ ﾂｨ 02 ｨｪ02 ｨｮ08ｨ 09ｨｪｨｨ09ｨ ｨｰｨｹ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ ｨｨ 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨｨ 04ｨｪｨ ﾂｨｨｨｬ04ｨｦ 05000002ｨｺｨｰ 06ｨｰ 07080207ｨ 08ｨ ｨｰｨ. 0208ｨｮ00ｨｨｨｬ ｨｪ02010609ｨｰｨ ｨｰｨｺ06ｨｬ ｨ 0605ｨｹ03ｨｨ01 0904ｨ 060806ｨｺ 0709050702ｨｰ0907 090604ｨｬ0603ｨｪ0609ｨｰｨｹ 090200ｨｬ02ｨｪｨｰｨｨ080609ｨ ｨｪｨｨ07 07ｨ 02ｨｨ02ｨｪｨｰ0609 ｨｪｨ 0706010008ｨｮ070704 09 0706ｨｨ09ｨｺｨ 01 0706050603ｨｨｨｰ0205ｨｹｨｪ060006 05000002ｨｺｨｰｨ, ｨｰ060001ｨ ｨｺｨ ｨｺ 09 0102ｨｦ09ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ04ｨｦ 05000002ｨｺｨｰ 06ｨｰ 07080207ｨ 08ｨ ｨｰｨ ｨｬ0603ｨｪ06 06ｨ ｨｪｨ 08ｨｮ03ｨｨｨｰｨｹ ｨｨ 09 ｨｬｨ 0506ｨｦ 0706 08ｨ 04ｨｬ0208ｨｮ 0904ｨ 0608ｨｺ02. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: J Natl Cancer Inst 2010;Aug;18;102(16): 1216ｨC1217,1223 1 71 7 FDA 0708ｨｨｨｪ070506 08020302ｨｪｨｨ02 06ｨ 06ｨｰ04040902 09 0804ｨｪｨｺｨ 09ｨｰ08ｨ ｨｪ04 07080207ｨ 08ｨ ｨｰｨ 09ｨｨｨ ｨｮｨｰ08ｨ ｨｬｨｨｨｪ (000208ｨｨ01ｨｨｨ, Abbott Laboratories). 02ｨｪ06 0609ｨｪ06090409ｨ 02ｨｰ0907 ｨｪｨ 080204ｨｮ05ｨｹｨｰｨ ｨｰｨ 01 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ060006 ｨｨ090704ｨｰｨ ｨｪｨｨ07 SCOUT, 0709050709030200060907 ﾂｨ 09ｨｰｨｹ06 0209050204 0102000205060307 5
130003020600060105080603 06030901020902010606 020003010808 06 0004090204 01 1 2011 0209050204 0102000205060307 6 0708060008ｨ ｨｬｨｬ04 070609ｨｰｨｬｨ 08ｨｺ02ｨｰｨｨｨｪ0006090401 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ, 09 ｨｺ06ｨｰ060806ｨｬ ｨｨ04ｨｮ ﾂｨ 050609ｨｹ 0905ｨｨ07ｨｪｨｨ02 09ｨｨｨ ｨｮｨｰ08ｨ ｨｬｨｨｨｪｨ ｨｪｨ 0902080607ｨｰｨｪ0609ｨｰｨｹ 050505. 0306 020006 080204ｨｮ05ｨｹｨｰｨ ｨｰｨ ｨｬ 090407090502ｨｪ06, ﾂｨｰ06 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ02 ｨｮｨｺｨ 04ｨ ｨｪｨｪ060006 07080207ｨ 08ｨ ｨｰｨ 090607080609060301ｨ 050609ｨｹ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02ｨｬ ｨｪｨ 16 % 08ｨｨ09ｨｺｨ 050505, 09080201ｨｨ ｨｺ06ｨｰ06080401 02010008, 020600, 0609ｨｰｨ ｨｪ0609ｨｺｨ 0902080102ｨ ｨｨ 09ｨｬ0208ｨｰｨｹ. 0308ｨｨ 05ｨｰ06ｨｬ 09 0908ｨ 09ｨｪ02ｨｪｨｨｨｨ 09 0705ｨ 0202ｨ 06 ｨｨｨｬ0205ｨ 09ｨｹ ｨｪ02 09ｨｰ0605ｨｹ ｨｮ03 ｨｨ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪｨ 07 0706ｨｰ020807 090209ｨ, 090502010609ｨ ｨｰ0205ｨｹｨｪ06 ｨｪ0200ｨ ｨｰｨｨ09ｨｪ0402 07060905020109ｨｰ09ｨｨ07 09 06ｨｰｨｪ060302ｨｪｨｨｨｨ 050505 0709ｨｪ06 07080209ｨ 05ｨｨ08ｨｮ06ｨｰ. 01ｨ 0609ｨｪ0609ｨ ｨｪｨｨｨｨ 070605ｨｮ ﾂ02ｨｪｨｪ0401 01ｨ ｨｪｨｪ0401 FDA 0802ｨｺ06ｨｬ02ｨｪ010609ｨ 0506 0908ｨ ﾂｨ ｨｬ 070802ｨｺ08ｨ ｨｰｨｨｨｰｨｹ 090407ｨｨ090409ｨ ｨｰｨｹ 0802020207ｨｰ04 ｨｪｨ 09ｨｨｨ ｨｮｨｰ08ｨ ｨｬｨｨｨｪ, ｨ 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬ ｪ 070802ｨｺ08ｨ ｨｰｨｨｨｰｨｹ 020006 0708ｨｨ00ｨｬ. 0306090502 0607ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪｨｨ07 04ｨ 07090502ｨｪｨｨ07 FDA ｨｺ06ｨｬ07ｨ ｨｪｨｨ07-070806ｨｨ04090601ｨｨｨｰ0205ｨｹ 09060005ｨ 09ｨｨ05ｨ 09ｨｹ 0106ｨ 0806090605ｨｹｨｪ06 070802ｨｺ08ｨ ｨｰｨｨｨｰｨｹ 07080601ｨ 03ｨｨ 07080207ｨ 08ｨ ｨｰｨ. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: FDA (http://www.fda.gov/newsevents/ Newsroom/PressAnnouncements/ ucm228812.htm) 1 71 7 AHRQ 07080201050603ｨｨ0506 090604ｨｪｨ 0008ｨ 030102ｨｪｨｨ02 09 08ｨ 04ｨｬ020802 34 ｨｬ05ｨｪ 01060505. 04ｨ 08ｨ 0408ｨ ｨ 06ｨｰｨｺｨｮ 05000002ｨｺｨｰｨｨ09ｨｪ0401 ｨｬ0208 0706 ｨ 0608ｨｹｨ 02 09 0601ｨｪ06ｨｦ ｨｨ04 10 05ｨｨ01ｨｨ08ｨｮ06ｨｴｨｨ01 0708ｨｨ ﾂｨｨｨｪ 09ｨｬ0208ｨｰｨｨ 09 050108 ｪ 09ｨｪｨｮｨｰ08ｨｨｨ 0605ｨｹｨｪｨｨ ﾂｨｪ04ｨｬｨｨ ｨｨｨｪ0002ｨｺ02ｨｨ07ｨｬｨｨ. 0306 0909020102ｨｪｨｨ07ｨｬ 0002ｨｪｨｰ080609 0706 ｨｺ06ｨｪｨｰ08060506 ｨｨ 07080600ｨｨ05ｨ ｨｺｨｰｨｨｨｺ02 04ｨ ｨ 06050209ｨ ｨｪｨｨｨｦ 020302000601ｨｪ06 09 050108 09040709050702ｨｰ0907 06ｨｺ060506 2 ｨｬ05ｨｪ 0905ｨｮ ﾂｨ 0209 09ｨｪｨｮｨｰ08ｨｨｨ 0605ｨｹｨｪｨｨ ﾂｨｪ0401 ｨｨｨｪ0002ｨｺ02ｨｨｨｦ, ﾂｨｰ06 090502 ﾂ00ｨｰ 04ｨ 0906ｨ 06ｨｦ 100 ｨｰ0409. 09ｨｬ0208ｨｰ02ｨｦ. 030806ｨ 0502ｨｬｨ 060906ｨ 02ｨｪｨｪ06 ｨ ｨｺｨｰｨｮｨ 05ｨｹｨｪｨ 09 ｨｮ09050609ｨｨ0701 070609ｨｰ0607ｨｪｨｪ06 08ｨ 09ｨｰｨｮｨｴ020006 ﾂｨｨ0905ｨ ｨ ｨｬｨ ｨｮ05ｨ ｨｰ0608ｨｪ0401 06070208ｨ 02ｨｨｨｦ ｨｨ ｨ 0605ｨｹ03060006 ﾂｨｨ0905ｨ 07ｨ 02ｨｨ02ｨｪｨｰ0609, ｨｪｨ 01060107ｨｴｨｨ010907 09 09ｨｰｨ 02ｨｨ06ｨｪｨ 08ｨ 01 0105ｨｨｨｰ0205ｨｹｨｪ060006 070802ｨ 0409ｨ ｨｪｨｨ07, ｨｪｨ 0708ｨｨｨｬ0208, 09 ｨｰ0208ｨｬｨｨｨｪｨ 05ｨｹｨｪ06ｨｦ 0706 ﾂ02 ﾂｨｪ06ｨｦ ｨｪ02010609ｨｰｨ ｨｰ06 ﾂｨｪ0609ｨｰｨｹ06. 020507 ｨｰ060006, ﾂｨｰ06ｨ 04 05000002ｨｺｨｰ 06ｨｰ 07060106ｨ ｨｪ0401 ｨｬ0208 ｨ 0405 ｨｬｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪ04ｨｬ, AHRQ 09 0906ｨｰ08ｨｮ01ｨｪｨｨ ﾂ0209ｨｰ0902 09 0108ｨｮ00ｨｨｨｬｨｨ 060800ｨ ｨｪｨｨ04ｨ 02ｨｨ07ｨｬｨｨ, 09 ｨｰ06ｨｬ ﾂｨｨ090502 01ｨ 02ｨｨ06ｨｪｨ 05ｨｹｨｪ04ｨｬ ｨｨｨｪ09ｨｰｨｨｨｰｨｮｨｰ06ｨｬ 040106080609ｨｹ07 050108, 090609ｨｰｨ 09ｨｨ0506 0907ｨｨ0906ｨｺ 070806ｨ 0502ｨｬ, 0709050706ｨｴｨｨ010907 07080201ｨｬ02ｨｰ06ｨｬ 010507 ｨｪｨ ｨｮ ﾂｨｪ0401 ｨｨ040409ｨｺｨ ｨｪｨｨｨｦ. 05080201ｨｨ ｨｪｨｨ01: 090407090502ｨｪｨｨ02 ｨｨ09ｨｰ06 ﾂｨｪｨｨｨｺ0609 ｨｨ 07080600ｨｨ05ｨ ｨｺｨｰｨｨｨｺｨ 09ｨｪｨｮｨｰ08ｨｨｨ 0605ｨｹｨｪｨｨ ﾂｨｪ0401 ｨｨｨｪ0002ｨｺ02ｨｨｨｦ, ｨｮ05ｨｮ ﾂ0302ｨｪｨｨ02 0708ｨ ｨｺｨｰｨｨｨｺｨｨ ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｨ07 ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺ0609 ｨｨ ｨ 06050202 ｨｰ0209ｨｪ0602 0906ｨｰ08ｨｮ01ｨｪｨｨ ﾂ0209ｨｰ0906 ｨｬ020301ｨｮ 08ｨ 0405ｨｨ ﾂｨｪ04ｨｬｨｨ 0905ｨｮ03ｨ ｨ ｨｬｨｨ 09 09ｨｨ09ｨｰ02ｨｬ02 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: AHRQ (http://www.ahrq.gov/news/ press/pr2010/haify10pr.htm) 1 71 7 00 09050603ｨｪ06ｨｬ 0708060202090902 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ07 ｨｺ06ｨｬ07ｨ ｨｪｨｨｨｦ-070806ｨｨ04090601ｨｨｨｰ020502ｨｦ 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ0401 07080207ｨ 08ｨ ｨｰ0609 ｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ060006 06ｨ 0608ｨｮ010609ｨ ｨｪｨｨ07 060906ｨ ｨｪ07ｨｺ06ｨｬ 09ｨｰ06ｨｨｨｰ 070806ｨ 0502ｨｬｨ 06090902ｨｴ02ｨｪｨｨ07 ｨｰｨ ｨｺ ｨｪｨ 040409ｨ 02ｨｬ060006 00ｨｺ06ｨｪ0005ｨｨｨｺｨｰｨ ｨｨｨｪｨｰ02080209060903. 0306ｨｪｨｨｨｬｨ 07 090906 09050603ｨｪ0609ｨｰｨｹ ｨｨ 0609ｨｰ0806ｨｰｨｮ 070806ｨ 0502ｨｬ04, ｨｬｨｪ0600ｨｨ02 09ｨｰ08ｨ ｨｪ04 070802010708ｨｨｨｪｨｨｨｬｨ 06ｨｰ 07060704ｨｰｨｺｨｨ 0708ｨｨ01ｨ ｨｰｨｹ 05ｨｰ06ｨｬｨｮ 07080602020909ｨｮ ｨｨ 020006 080204ｨｮ05ｨｹｨｰｨ ｨｰｨ ｨｬ 010609ｨｰｨｮ07ｨｪ0609ｨｰｨｹ ｨｨ 0708060408ｨ ﾂｨｪ0609ｨｰｨｹ. 00 ﾂｨ 09ｨｰｨｪ0609ｨｰｨｨ, 09 050108 09 03ｨｰｨ ｨｰ02 00ｨ 0909ｨ ﾂｨｮ0902ｨｰ09 09 2008 00. ｨ 0405 0708ｨｨｨｪ07ｨｰ 04ｨ ｨｺ06ｨｪ, 09 08ｨ ｨｬｨｺｨ 01 ｨｺ06ｨｰ0608060006 ｨｮｨｰ090208030100ｨｪ 08060102ｨｺ09 070609020102ｨｪｨｨ07 070806ｨｨ04090601ｨｨｨｰ020507 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ0401 07080207ｨ 08ｨ ｨｰ0609 ｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｮ09ｨｰ0806ｨｦ09ｨｰ09. 05060005ｨ 09ｨｪ06 02ｨｬｨｮ, ｨｺ06ｨｬ07ｨ ｨｪｨｨｨｨ 01060503ｨｪ04 070802010609ｨｰｨ 090507ｨｰｨｹ 0909020102ｨｪｨｨ07 06 08ｨ 04ｨｬ020802, 020205ｨｨ ｨｨ 070605ｨｮ ﾂｨ ｨｰ02050701 09090201 0705ｨ ｨｰ020302ｨｦ, 070802090403ｨ 06ｨｴｨｨ01 50 01060505. 01ｨ 0609ｨｪ0609ｨ ｨｪｨｨｨｨ 05ｨｰ06ｨｦ ｨｨｨｪ000608ｨｬｨ 02ｨｨｨｨ ｨ 0405ｨ 0607ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪｨ ｨ ｨ 04ｨ 01ｨ ｨｪｨｪ0401 06 09090201 0705ｨ ｨｰ0203ｨ 01, ｨ 010802090609ｨ ｨｪｨｪ0401 0502 ﾂ02ｨ ｨｪ04ｨｬ ｨｮ ﾂ0802030102ｨｪｨｨ07ｨｬ, 0908ｨ ﾂｨ ｨｬ, ｨｬ0201090009ｨｰ08ｨ ｨｬ ｨｨ 0108ｨｮ0006ｨｬｨｮ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ06ｨｬｨｮ 0702080906ｨｪｨ 05ｨｮ. 00 060607-10 0907ｨｨ09ｨｺｨ 0908ｨ ﾂ02ｨｦ, 070605ｨｮ ﾂｨｨ0903ｨｨ01 ｨｪｨ ｨｨｨ 0605ｨｹ03ｨｨ02 0706 08ｨ 04ｨｬ0208ｨ ｨｬ 09040705ｨ ｨｰ04, ｨ 0605ｨｹ0302 0909020006 06ｨｺｨ 04ｨ 050609ｨｹ ｨｺｨ 0801ｨｨ060506000609 (4 ﾂ0205060902ｨｺｨ ). 00ｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪ04ｨｦ 08ｨ 04ｨｬ0208 09040705ｨ ｨｰ 070802090409ｨｨ05 180 ｨｰ0409. 01060505. 0308ｨｨｨｬ02 ﾂｨ ｨｰ0205ｨｹｨｪ06, ﾂｨｰ06 09040705ｨ ｨｰ04 0908ｨ ﾂｨ ｨｬ 090609ｨｰｨ 09ｨｨ05ｨｨ 0706050609ｨｨｨｪｨｮ 06ｨ ｨｴ02ｨｦ 09ｨｮｨｬｨｬ04. 090605ｨｹ03ｨｨｨｪ09ｨｰ0906 ｨｨ04 ｨｪｨｨ01 06ｨ ｨｲ0709ｨｪ0706ｨｰ 070605ｨｮ ﾂ02ｨｪｨｨ02 0705ｨ ｨｰ020302ｨｦ 090906ｨｨｨｬ ｨｮ ﾂｨ 09ｨｰｨｨ02ｨｬ 09 08ｨ 0408ｨ ｨ 06ｨｰｨｺ02 0708060008ｨ ｨｬｨｬ ｨｨ ｨｬｨ ｨｰ0208ｨｨｨ 050609 09 08ｨ ｨｬｨｺｨ 01 ｨｪ02070802080409ｨｪ060006 07080600020909ｨｨ06ｨｪｨ 05ｨｹｨｪ060006 06ｨ 08ｨ 040609ｨ ｨｪｨｨ07. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: Heartwire (http://www.theheart.org/article/ 1156803.do#bib_1) 1 71 7 0308ｨ 09ｨｨｨｰ0205ｨｹ09ｨｰ0906 000205ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨｨｨ 090604050603ｨｨ0506 06ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ0609ｨｰｨｹ 04ｨ 0904070605ｨｪ02ｨｪｨｨ02 06ｨ ｨｴ0209ｨｰ0902ｨｪｨｪ0401 0708060008ｨ ｨｬｨｬ 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07, ｨｰｨ ｨｺｨｨ01, ｨｺｨ ｨｺ 09ｨ ｨｺ02ｨｨｨｪｨ 02ｨｨ07, 09ｨｺ08ｨｨｨｪｨｨｨｪ00 ｨｨ ｨｰ.01., ｨｪｨ ｨｬ0209ｨｰｨｪ0402 0905ｨ 09ｨｰｨｨ. 020507 ｨｰ060006, ﾂｨｰ06ｨ 04 0706ｨｬ06 ﾂｨｹ ｨｨｨｬ 09 08020302ｨｪｨｨｨｨ 05ｨｰｨｨ01 070806ｨ 0502ｨｬ, 09060401ｨ 02ｨｰ0907 09070202ｨｨｨ 05ｨｹｨｪｨ 07 0905ｨｮ03ｨ ｨ 06ｨ ｨｴ0209ｨｰ0902ｨｪｨｪ060006 040106080609ｨｹ07, ｨｺ06ｨｰ0608ｨ 07 ｨ ｨｮ0102ｨｰ 0906ｨｰ08ｨｮ01ｨｪｨｨ ﾂｨ ｨｰｨｹ 09 NICE 09 020205ｨｹ06 070605ｨｮ ﾂ02ｨｪｨｨ07 ｨｪ0204ｨ 09ｨｨ09ｨｨｨｬ0401 ｨｨ ｨ 09ｨｰ0608ｨｨｨｰ02ｨｰｨｪ0401 01ｨ ｨｪｨｪ0401 06 0106ｨｺｨ 04ｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｨ, ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ ｨｨ 05ｨｺ06ｨｪ06ｨｬｨｨ ﾂ0209ｨｺ06ｨｦ 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｰ0201 ｨｨ05ｨｨ ｨｨｨｪ0401 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ06050600ｨｨｨｦ, ｨｪｨ 0708ｨ 090502ｨｪｨｪ0401 ｨｪｨ 040106080609ｨｹ02 06ｨ ｨｴ0209ｨｰ09ｨ. 020507 0802ｨ 05ｨｨ04ｨ 02ｨｨｨｨ 01ｨ ｨｪｨｪ06ｨｦ 04ｨ 01ｨ ﾂｨｨ ｨ 0405 08ｨ 0408ｨ ｨ 06ｨｰｨ ｨｪ ｨｪ060904ｨｦ ｨ 06010302ｨｰ, 09060005ｨ 09ｨｪ06 ｨｺ06ｨｰ060806ｨｬｨｮ 07080201070605ｨ 00ｨ 02ｨｰ0907 090401020502ｨｪｨｨ02 4 ｨｬ050801 00ｨｮｨｪｨｰ0609 09ｨｰ020805ｨｨｨｪ000609 09 000601, 0708ｨｨ ﾂ02ｨｬ 05ｨｰｨ 09ｨｮｨｬｨｬｨ ｨｪ02 04ｨ 09ｨｨ09ｨｨｨｰ 06ｨｰ 0108ｨｮ00ｨｨ01 09ｨｰｨ ｨｰ02ｨｦ ｨ 06010302ｨｰｨ. 05ｨ 05000002ｨｺｨｰｨｨ09ｨｪ0402 ｨｬ020804 09 ｨ 0608ｨｹｨ 02 09 ｨｰｨ ｨｺｨｨｨｬｨｨ 04ｨ ｨ 06050209ｨ ｨｪｨｨ07ｨｬｨｨ, ｨｺｨ ｨｺ ｨｺｨｮ0802ｨｪｨｨ02 ｨｨ 0603ｨｨ0802ｨｪｨｨ02, 0708ｨ 09ｨｨｨｰ0205ｨｹ09ｨｰ0906ｨｬ 07080201070605ｨ 00ｨ 02ｨｰ0907 090604ｨｪｨ 0008ｨ 030102ｨｪｨｨ02. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: NICE (http://www.nice.org.uk/ newsroom/news/localauthorities- PlacedRightAtTheForefront.jsp) 1 71 7 0604ｨ 04ｨｰ06 ﾂｨｪ0602 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ02 ｨｪ06090401 ｨｰ0201ｨｪ06050600ｨｨｨｦ ｨｬ060302ｨｰ 06ｨｺｨ 04ｨ ｨｰｨｹ0907 ｨｪ02 ｨｬ02ｨｪｨｹ0302ｨｦ 070806ｨ 0502ｨｬ06ｨｦ, ﾂ02ｨｬ ｨｨ01 ｨｪｨｨ04ｨｺｨ 07 010609ｨｰｨｮ07ｨｪ0609ｨｰｨｹ. 0306ｨｺｨ 04ｨ ｨｰ0205ｨｹｨｪｨ 09ｨｨｨｰｨｮｨ 02ｨｨ07, ｨｺ06ｨｰ0608ｨ 07 08ｨ 04090608ｨ - ﾂｨｨ09ｨ 02ｨｰ0907 09 ｨｪ0209ｨｺ0605ｨｹｨｺｨｨ01 03ｨｰｨ ｨｰｨ 01 050108. 00 000608060102 0209ｨｰｨｨｨｪ (060201ｨ 09) ｨｺｨ 0801ｨｨ06050600 06ｨ 09ｨｨｨｪ00ｨｪ 09 0904070605ｨｪ02ｨｪｨｨｨｨ ｨ 0605ｨｹ03060006 ﾂｨｨ0905ｨ 09ｨｰ02ｨｪｨｰｨｨ080609ｨ ｨｪｨｨｨｦ 090609ｨｮ010609 (ｨｮ09ｨｰｨ ｨｪ0609ｨｺｨ ｨ 06050202 30 09ｨｰ02ｨｪｨｰ0609 ｨｮ 0601ｨｪ060006 07ｨ 02ｨｨ02ｨｪｨｰｨ ) ｨ 0204 010609ｨｰｨ ｨｰ06 ﾂｨｪ0401 ｨｪｨ ｨｰ06 0706ｨｺｨ 04ｨ ｨｪｨｨｨｦ, 07080609020102ｨｪｨｨｨｨ ｨｬｨｪ060006ｨｺ08ｨ ｨｰｨｪ0401 ｨ ｨｪ00ｨｨ060008ｨ 00ｨｨｨｦ 0708ｨｨ ｨｪ0608ｨｬｨ 05ｨｹｨｪ0401 080204ｨｮ05ｨｹｨｰｨ ｨｰｨ 01 ｨｪｨ 0008ｨｮ0406 ﾂｨｪ0401 070806ｨ, ｨｨｨｬ0705ｨ ｨｪｨｰｨ 02ｨｨｨｨ ｨｺｨ 0801ｨｨ0609ｨｰｨｨｨｬｨｮ0507ｨｰ0608ｨ 0708ｨｨ 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨｨｨ 0706ｨｺｨ 04ｨ ｨｪｨｨｨｦ ｨｨ ｨｪ02070605ｨｮ ﾂ02ｨｪｨｨｨｨ ｨｨｨｪ000608ｨｬｨｨ080609ｨ ｨｪｨｪ060006 09060005ｨ 09ｨｨ07 06ｨｰ 07ｨ 02ｨｨ02ｨｪｨｰｨ 06ｨ ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ060006 ｨｮ09ｨｰ0806ｨｦ09ｨｰ09ｨ 09ｨｪ02 06ｨ 0604ｨｪｨ ﾂ02ｨｪｨｪ0401 0706ｨｺｨ 04ｨ ｨｪｨｨｨｦ. 0009020006 09 09090704ｨｨ 09 05ｨｰｨｨｨｬ 070601ｨ ｨｪ06 0707ｨｰｨｹ 09ｨｮ0102ｨ ｨｪ0401 ｨｨ09ｨｺ0609. 05010601ｨｪ04ｨｬ 06ｨ 08ｨ 0406ｨｬ 09 03ｨｰｨ ｨｰ02 000508ｨｨ0502ｨｪ01 ｨ 0405ｨｨ ｨｮ09060502ｨｪ04 0109ｨ ｨｺｨ 0801ｨｨ06050600ｨ ｨｨ ｨｰｨ ｨｺ0302 070601ｨ ｨｪ04 09ｨｮ0102ｨ ｨｪ0402 ｨｨ09ｨｺｨｨ ｨｨ04-04ｨ ｨｮ09ｨｰｨ ｨｪ0609ｨｺｨｨ 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬ ｨｬｨｪ06030209ｨｰ09ｨ 09ｨｰ02ｨｪｨｰ0609 0708ｨｨ 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨｨｨ 0706ｨｺｨ 04ｨ ｨｪｨｨｨｦ 010507 05ｨｰ060006. 0309ｨｰ0209ｨｰ0902ｨｪｨｪ06, 090604ｨｪｨｨｨｺｨ 02ｨｰ ｨｬ040905ｨｹ 06 040506ｨｮ0706ｨｰ0802ｨ 0502ｨｪｨｨ0701 06ｨｰ010205ｨｹｨｪ0401 0908ｨ ﾂ02ｨｦ 09 020205ｨｹ06 05ｨｨ ﾂｨｪ06ｨｦ 090400060104. 0201ｨｪｨ ｨｺ06 0906 09090201 0905ｨｮ ﾂｨ 0701 0908ｨ ﾂｨｨ 06ｨｰ09ｨｰｨ ｨｨ09ｨ 06ｨｰ 09090606 070604ｨｨ02ｨｨ06 ｨｨ 000609060807ｨｰ 06 07080600020909ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｬ 070802090502010609ｨ ｨｪｨｨｨｨ 0906 09ｨｰ060806ｨｪ04 ｨｺ0605050200. 00 09ｨｨｨｰｨｮｨ 02ｨｨｨｨ, 08ｨ 04090208ｨｪｨｮ090302ｨｦ0907 09 060201ｨ 0902, 08ｨ 04ｨ ｨｨ08ｨ ｨｰ0205ｨｹ09ｨｰ09ｨ 05ｨｺ09070208ｨｰｨｪ060006 09060902ｨｰｨ ｨｪｨ ﾂｨ 05ｨｨ09ｨｹ 0706090502 01020907ｨｰｨｨ ｨ ｨｪ06ｨｪｨｨｨｬｨｪ0401 090606ｨ ｨｴ02ｨｪｨｨｨｦ 06 040506ｨｮ0706ｨｰ0802ｨ 0502ｨｪｨｨ0701, 07060709ｨｨ0903ｨｨ010907 0706090502 ｨｰ060006, ｨｺｨ ｨｺ 0106ｨｺｨｰ0608ｨｮ ｨ 0405ｨ 0708020105060302ｨｪｨ 01060503ｨｪ0609ｨｰｨｹ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ060006 01ｨｨ0802ｨｺｨｰ0608ｨ 09 09ｨｰ080607ｨｴ02ｨｬ0907 00060907ｨｨｨｰｨ 0502. 08ｨ ｨｺ 07080201070605ｨ 00ｨ 02ｨｰ 09ｨ ｨｬ 09070202ｨｨｨ 05ｨｨ09ｨｰ, ｨ ｨｪ06ｨｪｨｨｨｬｨｪ0402 090606ｨ ｨｴ02ｨｪｨｨ07 ｨｪｨ 0708ｨ 090502ｨｪ04 020006 ｨ 040903ｨｨｨｬｨｨ ｨｺ0605050200ｨ ｨｬｨｨ. 08ｨ 0801ｨｨ06050600 ｨｨ04 000508ｨｨ0502ｨｪ01ｨ ｨｰ060302 09 ﾂｨｨｨｰｨ 02ｨｰ, ﾂｨｰ06 ｨ 0405 ｨｮ09060502ｨｪ ｨｨ 09ｨｰｨ 05 06ｨ ｨｲ02ｨｺｨｰ06ｨｬ 09ｨｮ0102ｨ ｨｪ060006 070802090502010609ｨ ｨｪｨｨ07 ｨｨ04-04ｨ 07050601060006 06ｨｰｨｪ060302ｨｪｨｨ07 ｨｺ ｨｪ02ｨｬｨｮ ｨｺ0605050200 ｨｨ ｨ 01ｨｬｨｨｨｪｨｨ09ｨｰ08ｨ 02ｨｨｨｨ. 010209ｨｬ06ｨｰ0807 ｨｪｨ ｨｺｨ 03ｨｮｨｴｨｮ060907 ｨ ｨ 09ｨｮ0801ｨｪ0609ｨｰｨｹ 07060106ｨ ｨｪ0401 04ｨ 07090502ｨｪｨｨｨｦ, ｨｰｨ ｨｺｨｨ02 0905ｨｮ ﾂｨ ｨｨ 09070605ｨｪ02 ｨｬ0600ｨｮｨｰ ｨｨｨｬ02ｨｰｨｹ ｨｬ0209ｨｰ06, 070609ｨｺ0605ｨｹｨｺｨｮ 09 050108 010609ｨｰｨ ｨｰ06 ﾂｨｪ06 03ｨｨ0806ｨｺ06 0708ｨｨｨｪ07ｨｰｨ 0708ｨ ｨｺｨｰｨｨｨｺｨ ｨｨ04ｨｮ ﾂ02ｨｪｨｨ07 ｨｬｨｪ02ｨｪｨｨ07 ｨｺ0605050200 0708ｨｨ 060202ｨｪｨｺ02 07080600020909ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ 010207ｨｰ0205ｨｹｨｪ0609ｨｰｨｨ. 0306 0708ｨｨ ﾂｨｨｨｪ02 09050603ｨｪ0609ｨｰｨｨ 09ｨｨｨｰｨｮｨ 02ｨｨｨｨ 010507 09060108ｨ ｨｪ02ｨｪｨｨ07 ｨｬｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪ06ｨｦ 06ｨ ｨｲ02ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 070806ｨｨ0901060107ｨｴ020006 09 ｨｪ0200 0904ｨｪｨｮ030102ｨｪ04 ｨ 0405ｨｨ 09ｨｬ0203ｨ ｨｰｨｹ0907 0708020109ｨｰｨ 09ｨｨｨｰ0205ｨｨ ACC ｨｨ SCAI. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: Heartwire (http://www.theheart.org/article/ 1156973.do#bib 1) 010807 ﾁ010403 060505090302020008010608 06 0809060106 ﾁ0305080603 040308020003010208000606 0808040206020902010608 1 71 7 02ｨｺ09ｨｨ0002ｨｪ06ｨｰ0208ｨ 07ｨｨ07 03ｨｨ0806ｨｺ06 0708ｨｨｨｬ02ｨｪ0702ｨｰ0907 ｨｺｨ ｨｺ 0708ｨｨ ｨ ｨｬｨ ｨｮ05ｨ ｨｰ0608ｨｪ06ｨｬ, ｨｰｨ ｨｺ ｨｨ 0708ｨｨ 09ｨｰｨ 02ｨｨ06ｨｪｨ 08ｨｪ06ｨｬ 0502 ﾂ02ｨｪｨｨｨｨ 020600. 0106 ｨｪ0201ｨ 09ｨｪ06 ｨ 0405ｨｨ 090409ｨｺｨ 04ｨ ｨｪ04 0906ｨｬｨｪ02ｨｪｨｨ07 06ｨｰｨｪ0609ｨｨｨｰ0205ｨｹｨｪ06 ｨｪ0206ｨ 010601ｨｨｨｬ0609ｨｰｨｨ ｨｨ 0706050204ｨｪ0609ｨｰｨｨ 05ｨｰ060006 ｨｬ02ｨｰ0601ｨ. 05060005ｨ 09ｨｪ06 ACC/ACA, 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ02 ｨｺｨｨ090506080601ｨ 0708ｨｨ ｨｪ0209ｨｰｨ ｨ ｨｨ05ｨｹｨｪ06ｨｦ 09ｨｰ02ｨｪ06ｨｺｨ 0801ｨｨｨｨ ｨｨ05ｨｨ ｨｪ020609050603ｨｪ00ｨｪｨｪ06ｨｬ 020600 ｨ 0204 070601ｨｲ00ｨｬｨ 090200ｨｬ02ｨｪｨｰｨ ST 06ｨｰｨｪ0609ｨｨｨｰ0907 ｨｺ 0702080906ｨｬｨｮ ｨｺ05ｨ 0909ｨｮ 0802ｨｺ06ｨｬ02ｨｪ01ｨ 02ｨｨｨｦ. 03080201070605ｨ 00ｨ 02ｨｰ0907, ﾂｨｰ06 0106070605ｨｪｨｨｨｰ0205ｨｹｨｪｨ 07 06ｨｺ09ｨｨ0002ｨｪｨ 02ｨｨ07 0706040906050702ｨｰ ｨｮｨｬ02ｨｪｨｹ03ｨｨｨｰｨｹ 0609ｨｰ080602 ｨｨ0302ｨｬｨｨ ﾂ0209ｨｺ0602 0706090802030102ｨｪｨｨ02, 070609ｨｺ0605ｨｹｨｺｨｮ ｨｮ 080701ｨ 07ｨ 02ｨｨ02ｨｪｨｰ0609 ｨｪｨ ｨ 050601ｨ 02ｨｰ0907 00ｨｨ0706ｨｺ09ｨｨ07 090905020109ｨｰ09ｨｨ02 04ｨ 09ｨｰ0607 03ｨｨ01ｨｺ0609ｨｰｨｨ 09 ｨｬｨ 0506ｨｬ ｨｺ08ｨｮ0002 ｨｺ0806090606ｨ 08ｨ ｨｴ02ｨｪｨｨ07 ｨｨ ｨｪ02ｨ 0102ｨｺ09ｨ ｨｰｨｪ060006 090606ｨｰｨｪ060302ｨｪｨｨ07 07020800ｨｮ04ｨｨｨｨ ｨｨ 0902ｨｪｨｰｨｨ050702ｨｨｨｨ. 08ｨ ｨｺ 06ｨｺｨ 04ｨ 050609ｨｹ, 07060106ｨ ｨｪ0402 0802ｨｺ06ｨｬ02ｨｪ01ｨ 02ｨｨｨｨ ｨｪ02 070601ｨｰ090208030102ｨｪ04 09020906ｨｬ06ｨｦ 0106ｨｺｨ 04ｨ ｨｰ0205ｨｹｨｪ06ｨｦ ｨ ｨ 0406ｨｦ 09 09ｨｨ0102 080204ｨｮ05ｨｹｨｰｨ ｨｰ0609 ｨｺｨ ﾂ0209ｨｰ0902ｨｪｨｪ0401 040806. 00 070806ｨｰｨｨ09060706050603ｨｪ0609ｨｰｨｹ 05ｨｰ06ｨｬｨｮ 080701 ｨｨｨｬ0206ｨｴｨｨ010907 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ01 ｨｨ090704ｨｰｨ ｨｪｨｨｨｦ 0706ｨｺｨ 04ｨ 05, ﾂｨｰ06 ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｨ02 ｨｺｨｨ090506080601ｨ 070806090602ｨｨ08ｨｮ02ｨｰ 09ｨ 04060907ｨ 04ｨｬ ｨｨ 070609040302ｨｪｨｨ02
13ｨｮ080609ｨｪ07 ｨｰ08ｨ ｨｪ09ｨ ｨｬｨｨｨｪｨ 04, ﾂｨｰ06 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ02ｨｰ 06ｨ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨｨｨ 0406ｨｪ04 ｨｪ02ｨｺ080604ｨ. 0906050202 ｨｰ060006, ｨｪ0201ｨ 09ｨｪｨｨｨｦ 09ｨｨ09ｨｰ02ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｨｨｦ 06ｨ 040608, 0904070605ｨｪ02ｨｪｨｪ04ｨｦ 0906ｨｰ08ｨｮ01ｨｪｨｨｨｺｨ ｨｬｨｨ 0806ｨｺ08ｨ ｨｪ060909ｨｺ060006 090606ｨ ｨｴ0209ｨｰ09ｨ, 09040709ｨｨ05 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 09ｨｬ0208ｨｰｨｪ0609ｨｰｨｨ ｨ 06050202 ﾂ02ｨｬ 09 3 08ｨ 04ｨ ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 020600, ｨｺ06ｨｰ060804ｨｬ ｨｪｨ 04ｨｪｨ ﾂｨ 050907 ｨｺｨｨ090506080601, 09 0908ｨ 09ｨｪ02ｨｪｨｨｨｨ 09 ｨｰ02ｨｬｨｨ, ｨｺ06ｨｬｨｮ ｨｪｨ 04ｨｪｨ ﾂｨ 050907 06ｨ 04 ﾂｨｪ04ｨｦ 09060401ｨｮ01. 00 09090704ｨｨ 09 05ｨｰｨｨｨｬ 090902 ｨｺ08ｨｮ07ｨｪ0402 ｨｺｨ 0801ｨｨ06050600ｨｨ ﾂ0209ｨｺｨｨ02 ｨ 09090602ｨｨｨ 02ｨｨｨｨ 0901060107ｨｰ0907 0906 ｨｬｨｪ02ｨｪｨｨｨｨ, ﾂｨｰ06 ｨｪ0206ｨ 010601ｨｨｨｬ04 0106070605ｨｪｨｨｨｰ0205ｨｹｨｪ0402 ｨｨ09090502010609ｨ ｨｪｨｨ07 010507 0607080201020502ｨｪｨｨ07 ｨｨ09ｨｰｨｨｨｪｨｪ06ｨｦ 080605ｨｨ 06ｨｺ09ｨｨ0002ｨｪ06ｨｰ0208ｨ 07ｨｨｨｨ 09 0502 ﾂ02ｨｪｨｨｨｨ 020600. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: Heartwire (http://www.theheart.org/ article/1125119.do) 1 71 7 05ｨ 05060006ｨｬ 0907ｨ 0902ｨｪｨｨ07 03ｨｨ04ｨｪｨｨ 07ｨ 02ｨｨ02ｨｪｨｰｨ 09 0609ｨｰｨ ｨｪ0609ｨｺ06ｨｦ 0902080102ｨ 09ｨｪ02 0502 ﾂ02ｨ ｨｪ060006 ｨｮ ﾂ0802030102ｨｪｨｨ07 0709050702ｨｰ0907 07080609020102ｨｪｨｨ02 050904. 08 090603ｨ 0502ｨｪｨｨ06, 09 070601ｨ 09050706ｨｴ02ｨｬ ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ0902 0905ｨｮ ﾂｨ 0209 0802ｨ ｨｪｨｨｨｬｨ 02ｨｨ06ｨｪｨｪ0402 ｨｬ0208060708ｨｨ07ｨｰｨｨ07 0904070605ｨｪ0706ｨｰ0907 0905ｨｮ ﾂｨ ｨｦｨｪ04ｨｬｨｨ 070806010603ｨｨｨｬｨｨ, ｨｪ02 ｨｨｨｬ0206ｨｴｨｨｨｬｨｨ 010609ｨｰｨ ｨｰ06 ﾂｨｪ060006 ｨｮ080609ｨｪ07 0706010006ｨｰ0609ｨｺｨｨ, ｨｨ 08ｨｮｨｺ06090601ｨｨｨｰｨｹ ｨｨ01 0102ｨｦ09ｨｰ09ｨｨ07ｨｬｨｨ 0708ｨｨ010601ｨｨｨｰ0907 01ｨｨ090702ｨｰ ﾂ0208ｨｮ 050003. 0106 ｨｰ02070208ｨｹ 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 07060106ｨ ｨｪ06ｨｦ 0706ｨｬ06ｨｴｨｨ ｨｬ060302ｨｰ 09060408ｨ 09ｨｰｨｨ, 070609ｨｺ0605ｨｹｨｺｨｮ 07080609020100ｨｪｨｪ04ｨｦ 09ｨｨ09ｨｰ02ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｨｨｦ 06ｨ 040608 0706ｨｺｨ 04ｨ 05, ﾂｨｰ06 09 0905ｨｮ ﾂｨ 02 09ｨｪ02ｨ 0605ｨｹｨｪｨｨ ﾂｨｪ06ｨｦ 0609ｨｰｨ ｨｪ0609ｨｺｨｨ 0902080102ｨ 01ｨｨ090702ｨｰ- ﾂ0208ｨｮ 09050201ｨｮ02ｨｰ 09060908020106ｨｰ06 ﾂｨｨｨｰｨｹ0907 ｨｪｨ 06ｨ ｨｲ0709ｨｪ02ｨｪｨｨｨｨ ｨｰ0201ｨｪｨｨｨｺｨｨ 050904 ｨｰ0605ｨｹｨｺ06 09 ｨｺ06ｨｬ0708020909ｨｨ07ｨｬｨｨ 0008ｨｮ01ｨｪ06ｨｦ ｨｺ0502ｨｰｨｺｨｨ, ｨｪ02030205ｨｨ 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ06ｨｦ, 09ｨｺ0506 ﾂｨ 06ｨｴ02ｨｦ 02ｨｴ00 ｨｨ 0708ｨｨｨｪｨｮ01ｨｨｨｰ0205ｨｹｨｪｨｮ06 0902ｨｪｨｰｨｨ050702ｨｨ06 050000ｨｺｨｨ01. 00 0702080906ｨｬ 0905ｨｮ ﾂｨ 02 ｨｪｨ ｨ 050601ｨ 02ｨｰ0907 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 090403ｨｨ09ｨ 02ｨｬ0609ｨｰｨｨ ｨｪｨ 2,4 % (0204 = 1,22; 95 % 0206 1,01ｨC11,46). 0609ｨｰ06 ﾂｨｪｨｨｨｺ: Lancet 2010;Nov;6;376(9752):1522ｨC1524 1 71 7 010209ｨｬ06ｨｰ0807 ｨｪｨ ｨ 0605ｨｹ030602 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 05000002ｨｺｨｰｨｨ09ｨｪ0401 00ｨｨ0706ｨｰ02ｨｪ04ｨｨ09ｨｪ0401 07080207ｨ 08ｨ ｨｰ0609, 070806ｨ 0502ｨｬｨ 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ06ｨｦ ｨｺ ｨｰ0208ｨ 07ｨｨｨｨ 0801 0706-07080203ｨｪ02ｨｬｨｮ 0609ｨｰｨ 00ｨｰ0907 ｨ ｨｺｨｰｨｮｨ 05ｨｹｨｪ06ｨｦ. 0701ｨｨ09ｨｨｨｰ0205ｨｹｨｪ06, ｨｪ06 0601ｨｪｨｨｨｬ ｨｨ04 07ｨｮｨｰ02ｨｦ 0200 08020302ｨｪｨｨ07 ｨｬ060302ｨｰ 09ｨｰｨ ｨｰｨｹ 0906040806030102ｨｪｨｨ02 01ｨｨ08ｨｮ0800ｨｨ ﾂ0209ｨｺｨｨ01 ｨｬ02ｨｰ06010609 0502 ﾂ02ｨｪｨｨ07, 06 ﾂ00ｨｬ 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ06ｨｰ 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 08020906050602ｨｨ06ｨｪｨｪ060006 ｨｨ09090502010609ｨ ｨｪｨｨ07 Symplicity HTN-2. 00 08ｨ ｨｬｨｺｨ 01 020006 0904070605ｨｪ02ｨｪｨｨ07 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬ 09 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ06ｨｦ 0801 070806090601ｨｨ05ｨ 09ｨｹ 09ｨｨｨｬ07ｨ ｨｰｨｨ ﾂ0209ｨｺｨ 07 0102ｨｪ020809ｨ 02ｨｨ07 0706 ﾂ02ｨｺ 0708ｨｨ 0706ｨｬ06ｨｴｨｨ 08ｨ 01ｨｨ06 ﾂｨ 09ｨｰ06ｨｰｨｪ06ｨｦ ｨ ｨ 050702ｨｨｨｨ ﾂ02080204 070806090902ｨｰ 0706 ﾂ02 ﾂｨｪ0401 ｨ 08ｨｰ0208ｨｨｨｦ, 05ｨｨｨ 06 07080601060503ｨ 05ｨ 09ｨｹ ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｪｨ 07 08ｨ ｨｪ0202 ｨｬ0201ｨｨｨｺｨ ｨｬ02ｨｪｨｰ0604ｨｪｨ 07 ｨｰ0208ｨ 07ｨｨ07. ﾁ02080204 030209ｨｰｨｹ ｨｬ020907020209 08ｨ 04ｨｪｨｨ02ｨ ｨｬ020301ｨｮ 0008ｨｮ0707ｨ ｨｬｨｨ 09 ｨｮ080609ｨｪ02 0802 090609ｨｰｨ 09050705ｨ 33/11 ｨｬｨｬ 08ｨｰ.09ｨｰ. (p < 0,0001), 0708ｨｨ ｨｰ06ｨｬ ﾂｨｰ06 01ｨ ｨｪｨｪ04ｨｦ 05000002ｨｺｨｰ 09060108ｨ ｨｪ07050907 ｨｨ 0907060905020109ｨｰ09ｨｨｨｨ, ｨ 09ｨ ｨｬｨ 070806020201ｨｮ08ｨ ｨｪ02 ｨｨｨｬ0205ｨ 0706ｨ 06 ﾂｨｪ0401 05000002ｨｺｨｰ0609. 0808ｨｨｨｰｨｨｨｺｨｨ ｨｨ09090502010609ｨ ｨｪｨｨ07 ｨｮｨｺｨ 040409ｨ 06ｨｰ ｨｪｨ ｨｰ06, ﾂｨｰ06 ｨｪ0209ｨｬ06ｨｰ0807 ｨｪｨ 090702 ﾂｨ ｨｰ050706ｨｴｨｨ02 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 0209ｨｰｨｹ ｨｪ0209ｨｺ0605ｨｹｨｺ06 04ｨ ｨｬ02 ﾂｨ ｨｪｨｨｨｦ. 02ｨｪｨｨ 0909060107ｨｰ0907 ｨｺ ｨｰ06ｨｬｨｮ, ﾂｨｰ06 09 080204ｨｮ05ｨｹｨｰｨ ｨｰｨ 01 ｨ ｨｺ0202ｨｪｨｰ 010205ｨ 02ｨｰ0907 ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｨ07 0802, 070605ｨｮ ﾂ02ｨｪｨｪ0402 0906 090802ｨｬ07 09ｨｨ04ｨｨｨｰｨ ｨｺ 0908ｨ ﾂｨｮ, ｨｰ060001ｨ ｨｺｨ ｨｺ 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 0106ｨｬｨ 03ｨｪｨｨ01 ｨｨ04ｨｬ020802ｨｪｨｨｨｦ ｨｪ02 09ｨｰ0605ｨｹ 0706ｨｺｨ 04ｨ ｨｰ0205ｨｹｨｪ04. 08 ｨｰ06ｨｬｨｮ 0302 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｮ02ｨｰ 070807ｨｬ0602 0908ｨ 09ｨｪ02ｨｪｨｨ02 09 ｨ ｨｪｨｰｨ 0006ｨｪｨｨ09ｨｰｨ ｨｬｨｨ 0802020207ｨｰ06080609 ｨｺ ｨ 05ｨｹ010609ｨｰ020806ｨｪｨｮ, 05000002ｨｺｨｰｨｨ09ｨｪ04ｨｬｨｨ 09 01ｨ ｨｪｨｪ06ｨｦ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ 09ｨｨｨｰｨｮｨ 02ｨｨｨｨ. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: Heartwire (http://www.theheart.org/ article/1151787.do) 1 71 7 0308020109ｨｰｨ 090502ｨｪ04 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨｨ09090502010609ｨ ｨｪｨｨ07 REVEAL, 09ｨｰｨ 0903020006 02ｨｴ00 0601ｨｪ06ｨｦ 08ｨ ｨ 06ｨｰ06ｨｦ, 0102ｨｬ06ｨｪ09ｨｰ08ｨｨ08ｨｮ06ｨｴ02ｨｦ ｨｪ0200ｨ ｨｰｨｨ09ｨｪ04ｨｦ 05000002ｨｺｨｰ 06ｨｰ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 0508ｨｨｨｰ0806070605ｨｰｨｨｨｪｨ. 01ｨｨ0706ｨｰ020406ｨｦ ｨｨ09090502010609ｨ ｨｪｨｨ07 07080201070605ｨ 00ｨ 050609ｨｹ, ﾂｨｰ06 ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｨ02 05ｨｰ060006 07080207ｨ 08ｨ ｨｰｨ 0706090502 ﾂ080209ｨｺ0603ｨｪ06ｨｦ ｨ ｨｪ00ｨｨ060705ｨ 09ｨｰｨｨｨｺｨｨ ｨｺ060806ｨｪｨ 08ｨｪ0401 ｨ 08ｨｰ0208ｨｨｨｦ ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 020600 09 070601ｨｲ00ｨｬ06ｨｬ 090200ｨｬ02ｨｪｨｰｨ ST 070604090605ｨｨｨｰ ｨｮｨｬ02ｨｪｨｹ03ｨｨｨｰｨｹ 08ｨ 04ｨｬ0208 ｨｪ02ｨｺ080604ｨ. 030605ｨｮ ﾂ02ｨｪｨｪ0402 01ｨ ｨｪｨｪ0402 0706ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ06 09 0908ｨ 09ｨｪ02ｨｪｨｨｨｨ 09 0705ｨ 0202ｨ 06 ｨｪｨｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 0702080906ｨｦ ｨｪ02010205ｨｨ, ｨｪｨｨ ﾂ02080204 12 ｨｪ02010205ｨｹ 0706 080204ｨｮ05ｨｹｨｰｨ ｨｰｨ ｨｬ 000406 ｨｪ02 ｨｪｨ ｨ 050601ｨ 050609ｨｹ 08ｨ 04ｨｪｨｨ0204 09 08ｨ 04ｨｬ020802 ｨｨｨｪ00ｨ 08ｨｺｨｰｨ. 0102 06ｨｰｨｬ02 ﾂ02ｨｪ06 ｨｰｨ ｨｺ0302 08ｨ 0405ｨｨ ﾂｨｨｨｦ 0706 0706ｨｺｨ 04ｨ ｨｰ020507ｨｬ 0802ｨｬ06010205ｨｨ080609ｨ ｨｪｨｨ07 ｨｬｨｨ06ｨｺｨ 0801ｨ 0904. 0306ｨｬｨｨｨｬ06 05ｨｰ060006 ｨ 09ｨｰ060804 070601 ﾂ0208ｨｺｨｨ09ｨ 06ｨｰ, ﾂｨｰ06 ｨｪｨ ｨ 050601ｨ 02ｨｰ0907 ｨｰ02ｨｪ0102ｨｪ02ｨｨ07 ｨｺ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ06 08ｨ 04ｨｬ0208ｨ ｨｪ02ｨｺ080604ｨ 0708ｨｨ ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｨｨｨ 0508ｨｨｨｰ0806070605ｨｰｨｨｨｪｨ 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬ 09ｨｰｨ 080302 70 0502ｨｰ. 06ｨｰ06 ｨｨ09090502010609ｨ ｨｪｨｨ02 070601ｨｰ0902080301ｨ 02ｨｰ 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨ 06050202 08ｨ ｨｪｨｪｨｨ01 08ｨ ｨ 06ｨｰ HEBE III ｨｨ REVIVAL-3, ｨｰｨ ｨｺ0302 0708060102ｨｬ06ｨｪ09ｨｰ08ｨｨ080609ｨ 0903ｨｨ01 ｨｪ0205000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 0508ｨｨｨｰ0806070605ｨｰｨｨｨｪｨ ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 020600. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: Heartwire (http://www.theheart.org/ article/1151621.do) 1 71 7 040204ｨｮ05ｨｹｨｰｨ ｨｰ04 03ｨｨ0806ｨｺ06 ｨｨ04090209ｨｰｨｪ060006 ｨｨ09090502010609ｨ ｨｪｨｨ07 JUPITER 0706ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ06 ｨｪｨ 04ｨｪｨ ﾂ02ｨｪｨｨ02 09ｨｰｨ ｨｰｨｨｨｪ0609 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬ 09 ｨｪ0608ｨｬｨ 05ｨｹｨｪ04ｨｬｨｨ 04ｨｪｨ ﾂ02ｨｪｨｨ07ｨｬｨｨ 09030103, ｨｪ06 09040906ｨｺｨｨｨｬ ｨｮ080609ｨｪ02ｨｬ 050403 09ｨｪｨｨ03ｨ 02ｨｰ 08ｨｨ09ｨｺ 050505, 08ｨ 0903ｨｨ080707, ｨｰｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 0706ｨｺｨ 04ｨ ｨｪｨｨ07 010507 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 01ｨ ｨｪｨｪ0401 07080207ｨ 08ｨ ｨｰ0609. 0006070802ｨｺｨｨ 05ｨｰ06ｨｬｨｮ, 090604ｨｪｨｨｨｺ0506 ｨｬｨｪ060006 0906070806090609 06 ｨｪｨ 010003ｨｪ0609ｨｰｨｨ 050403 09 ｨｺｨ - ﾂ0209ｨｰ0902 07080201ｨｨｨｺｨｰ0608ｨ 050505, 090201ｨｹ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 ｨｨ01 ｨ ｨ 09060506ｨｰｨｪ060006 08ｨｨ09ｨｺｨ 09 ｨｮ0706ｨｬ07ｨｪｨｮｨｰ06ｨｦ 08ｨ ｨ 06ｨｰ02 ｨ 040506 06 ﾂ02ｨｪｨｹ ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ04ｨｬ. 0808ｨｮ07ｨｪ0602 ｨｨ09090502010609ｨ ｨｪｨｨ02 MESA ｨｰ060302 09ｨｰｨ 09ｨｨｨｰ 070601 0906ｨｬｨｪ02ｨｪｨｨ02 01ｨｨｨ 00ｨｪ0609ｨｰｨｨ ﾂ0209ｨｺｨｮ06 0202ｨｪｨｪ0609ｨｰｨｹ 050403 ｨｨ 09040109ｨｨ00ｨ 02ｨｰ ｨｪｨ 070208090602 ｨｬ0209ｨｰ06 090601020803ｨ ｨｪｨｨ02 ｨｺｨ 05ｨｹ02ｨｨ07 09 ｨｺ060806ｨｪｨ 08ｨｪ0401 090609ｨｮ01ｨ 01. 05060005ｨ 09ｨｪ06 020006 0708020109ｨ 08ｨｨｨｰ0205ｨｹｨｪ04ｨｬ 080204ｨｮ05ｨｹｨｰｨ ｨｰｨ ｨｬ, ｨｨｨｬ02ｨｪｨｪ06 05ｨｰ06ｨｰ 0706ｨｺｨ 04ｨ ｨｰ0205ｨｹ 0905ｨｮ03ｨｨ05 ｨｪｨ 010003ｨｪ04ｨｬ 07080201ｨｨｨｺｨｰ060806ｨｬ 0609050603ｨｪ02ｨｪｨｨｨｦ 0906 09ｨｰ060806ｨｪ04 050505, ｨｰ060001ｨ ｨｺｨ ｨｺ 050403 ｨｰｨ ｨｺ060904ｨｬ ｨｪ02 07090507050907. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: Medscape (http://www.medscape.com/ viewarticle/733057) 01030804020902010608 1 71 7 00 ｨｮ09050609ｨｨ0701 0906090802ｨｬ02ｨｪｨｪ06ｨｦ ｨｬ0201ｨｨ02ｨｨｨｪ04 0802ｨｪｨｰ0002ｨｪ06050600ｨｨ ﾂ0209ｨｺｨｨ02 ｨｬ02ｨｰ060104 01ｨｨｨ 00ｨｪ0609ｨｰｨｨｨｺｨｨ 09 ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨ02ｨｬ ｨｺ06ｨｪｨｰ08ｨ 09ｨｰｨｪ0401 07080207ｨ 08ｨ ｨｰ0609 070605ｨｮ ﾂｨ 06ｨｰ 090900 ｨ 0605ｨｹ030202 08ｨ 0907080609ｨｰ08ｨ ｨｪ02ｨｪｨｨ02. 010209ｨｬ06ｨｰ0807 ｨｪｨ 090902 06 ﾂ0209ｨｨ01ｨｪ0402 070802ｨｨｨｬｨｮｨｴ0209ｨｰ09ｨ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 0802ｨｪｨｰ0002ｨｪ06ｨｺ06ｨｪｨｰ08ｨ 09ｨｰｨｪ0401 0908020109ｨｰ09, 09 ｨｪｨｨｨｬｨｨ 09090704ｨ ｨｪ 080701 090208ｨｹ0004ｨｪ0401 0706ｨ 06 ﾂｨｪ0401 05000002ｨｺｨｰ0609, 09 ﾂｨ 09ｨｰｨｪ0609ｨｰｨｨ, ｨｺ06ｨｪｨｰ08ｨ 09ｨｰｨｨｨｪ01ｨｮ02ｨｨ080609ｨ ｨｪｨｪｨ 07 ｨｪ0200080607ｨ ｨｰｨｨ07. 05 020205ｨｹ06 0200 07080600ｨｨ05ｨ ｨｺｨｰｨｨｨｺｨｨ 09 ｨｪｨ 09ｨｰ0607ｨｴ0202 090802ｨｬ07 ｨｨ09070605ｨｹ04ｨｮ02ｨｰ0907 N-ｨ 0202ｨｰｨｨ0502ｨｨ09ｨｰ02ｨｨｨｪ, 0106ｨｰ07 05ｨｰ06ｨｰ ｨｬ02ｨｰ0601 0609ｨｰｨ 00ｨｰ0907 07080201ｨｬ02ｨｰ06ｨｬ 01ｨｨ09ｨｺｨｮ0909ｨｨｨｦ. 000902 ｨｰ06 ﾂｨｺｨｨ ｨｪｨ 01 00i03 09 09060708060902 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 07080207ｨ 08ｨ ｨｰｨ 0708ｨｨ 01ｨ ｨｪｨｪ06ｨｬ 090609ｨｰ0607ｨｪｨｨｨｨ 09ｨｰｨ 0907ｨｰ 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ060006 ｨｨ090704ｨｰｨ ｨｪｨｨ07 ACT ｨ 06050202 2000 07ｨ 02ｨｨ02ｨｪｨｰ0609, 0706ｨｺｨ 04ｨ 0903ｨｨ02, ﾂｨｰ06 ｨｪ02ｨｰ 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨｨ 04ｨｪｨ ﾂｨｨｨｬ06ｨｦ 08ｨ 04ｨｪｨｨ0204 0706 ﾂｨ 09ｨｰ06ｨｰ02 08ｨ 0409ｨｨｨｰｨｨ07 ｨｺ06ｨｪｨｰ08ｨ 09ｨｰｨｨｨｪ01ｨｮ02ｨｨ080609ｨ ｨｪｨｪ06ｨｦ ｨｪ0200080607ｨ ｨｰｨｨｨｨ ｨｬ020301ｨｮ N-ｨ 0202ｨｰｨｨ0502ｨｨ09ｨｰ02ｨｨｨｪ06ｨｬ ｨｨ 0705ｨ 0202ｨ 06. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: Heartwire (http://www.theheart.org/ article/1151175.do) 1 71 7 01ｨ ｨｨｨ 06050202 08ｨ 0907080609ｨｰ08ｨ ｨｪ00ｨｪｨｪ06ｨｦ 0708ｨｨ ﾂｨｨｨｪ06ｨｦ 09ｨｬ0208ｨｰｨｨ ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ0609, 070605ｨｮ ﾂｨ 06ｨｴｨｨ01 0502- ﾂ02ｨｪｨｨ02 0002ｨｬ0601ｨｨｨ 05ｨｨ0406ｨｬ 0706 0706090601ｨｮ 090301, 0709050706ｨｰ0907 0609050603ｨｪ02ｨｪｨｨ07 0906 09ｨｰ060806ｨｪ04 050505. 0306 01ｨ ｨｪｨｪ04ｨｬ 07080609020100ｨｪｨｪ060006 040806 FHN, ｨｮ01090602ｨｪｨｨ02 ﾂｨ 09ｨｰ06ｨｰ04 0002ｨｬ0601ｨｨｨ 05ｨｨ04ｨ 0106 030209ｨｰｨｨ 08ｨ 04 09 ｨｪ0201020506 070806ｨｰｨｨ09 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ0401 ｨｰ080201 09020100ｨｰ ｨｺ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ06 ｨｬｨ 090904 0904 0902080102ｨ, 060202ｨｪｨｨ09ｨ 090302ｨｦ0907 0708ｨｨ 0706ｨｬ06ｨｴｨｨ 000406. 04ｨ 04ｨｪｨｨ02ｨ 090609ｨｰｨ 09050705ｨ 13,8 00 (p < 0,001). 0809ｨｰ060804 ｨｨ09090502010609ｨ ｨｪｨｨ07, 0601ｨｪｨ ｨｺ06, ｨｪ02 04ｨ 0709050706ｨｰ 06 ｨｰ06ｨｬ, ﾂｨｰ06 ｨｪ0206ｨ 010601ｨｨｨｬ06 09090201 07ｨ 02ｨｨ02ｨｪｨｰ0609 07020802090601ｨｨｨｰｨｹ ｨｪｨ 01ｨ ｨｪｨｪ04ｨｦ 080203ｨｨｨｬ, 070609ｨｺ0605ｨｹｨｺｨｮ 06ｨｪ ｨｪ02 090902ｨｬ 070601010601ｨｨｨｰ ｨｨ 010609ｨｰｨ ｨｰ06 ﾂｨｪ06 0905060302ｨｪ 010507 0904070605ｨｪ02ｨｪｨｨ07. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: N Engl J Med 2010;363:2287ｨC2300. 03070905000201020902010608 1 71 7 0506090802ｨｬ02ｨｪｨｪ0402 0708020109ｨｰｨ 090502ｨｪｨｨ07 06 ｨ 02ｨｰｨ -ｨ 010802ｨｪ06ｨ 0506ｨｺｨ ｨｰ0608ｨ 01 0601ｨｪ0604ｨｪｨ ﾂｨｪ06 04ｨ 070802ｨｴｨ 06ｨｰ ｨｨ01 ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨ02 ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 04ｨ ｨ 06050209ｨ ｨｪｨｨ07ｨｬｨｨ, 090607080609060301ｨ 06ｨｴｨｨｨｬｨｨ0907 ｨ 0806ｨｪ010606ｨ 09ｨｰ08ｨｮｨｺ02ｨｨ02ｨｦ, 01ｨ 0302 ｨｪ0209ｨｬ06ｨｰ0807 ｨｪｨ ｨｪｨ 05ｨｨ ﾂｨｨ02 060905 ｨｨ05ｨｨ 090501. 000604ｨｬ0603ｨｪ06, ﾂｨｰ06 09 ｨ 05ｨｨ03ｨ ｨｦ03ｨｨ02 ｨｪ0209ｨｺ0605ｨｹｨｺ06 0502ｨｰ 07060106ｨ ｨｪｨ 07 ｨｰ06 ﾂｨｺｨ 040802ｨｪｨｨ07 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ 0702080209ｨｬ06ｨｰ0802ｨｪｨ, 070609ｨｺ0605ｨｹｨｺｨｮ 0802ｨｰ0806090702ｨｺｨｰｨｨ09ｨｪ0602 ｨｺ06000608ｨｰｨｪ0602 ｨｨ09090502010609ｨ ｨｪｨｨ02 09040709ｨｨ0506 09ｨｪｨｨ0302ｨｪｨｨ02 09ｨｬ0208ｨｰｨｪ0609ｨｰｨｨ ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 09020909, 0708ｨｨｨｪｨｨｨｬｨ 0903ｨｨ01 ｨ 02ｨｰｨ -ｨ 010802ｨｪ06ｨ 0506ｨｺｨ ｨｰ060804 09 0908ｨ 09ｨｪ02ｨｪｨｨｨｨ 09 ｨｰ02ｨｬｨｨ, ｨｺ06ｨｬｨｮ 06ｨｪｨｨ ｨｪ02 ｨｪｨ 04ｨｪｨ ﾂｨ 05ｨｨ09ｨｹ (27,2 ｨｨ 32,3 %, 090606ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06, p < 0,02). 0201ｨｪｨ ｨｺ06 09050201ｨｮ02ｨｰ ｨｨｨｬ02ｨｰｨｹ 09 09ｨｨ01ｨｮ, ﾂｨｰ06 ｨｨ04-04ｨ 0802ｨｰ0806090702ｨｺｨｰｨｨ09ｨｪ060006 01ｨｨ04ｨ ｨｦｨｪｨ 09ｨｰ020702ｨｪｨｹ 010609ｨｰ06090208ｨｪ0609ｨｰｨｨ 070605ｨｮ ﾂ02ｨｪｨｪ0401 080204ｨｮ05ｨｹｨｰｨ ｨｰ0609 ｨｪｨｨ04ｨｺｨ ｨｨ ｨｰ0802ｨ ｨｮ02ｨｰ0907 ｨｨ01 070601ｨｰ090208030102ｨｪｨｨ02 09 01060102 040806. 0609ｨｰ06 ﾂｨｪｨｨｨｺ: Arch Int Med 2010;170:880ｨC887 1 71 7 0006070802ｨｺｨｨ 08ｨ 0907080609ｨｰ08ｨ ｨｪ02ｨｪｨｪ06ｨｬｨｮ ｨｬｨｪ02ｨｪｨｨ06 06 ｨｰ06ｨｬ, ﾂｨｰ06 ｨｨｨｪ00ｨ 050702ｨｨ06ｨｪｨｪ0402 010805 ｨｪ02 06ｨｺｨ 040409ｨ 06ｨｰ 09ｨｨ09ｨｰ02ｨｬｨｪ060006 0102ｨｦ09ｨｰ09ｨｨ07, 09 ﾂｨ 09ｨｰｨｪ0609ｨｰｨｨ, ｨｪｨ ｨｮ000502090601ｨｪ04ｨｦ 06ｨ ｨｬ02ｨｪ, ｨｨｨｬ0206ｨｰ0907 0909020102ｨｪｨｨ07 06ｨ 06ｨ 08ｨ ｨｰｨｪ06ｨｬ. 08ｨｪｨ 05ｨｨ04 09ｨｰ08ｨ 0106090401 ｨ ｨ 04 01ｨ ｨｪｨｪ0401, 09ｨｺ0506 ﾂｨ 0903ｨｨｨｦ ｨ 06050202 380 ｨｰ0409. 07ｨ 02ｨｨ02ｨｪｨｰ0609, ｨｺ06ｨｰ060804ｨｬ ｨｪｨ 04ｨｪｨ ﾂｨ 05ｨｨ09ｨｹ ｨｰ0607ｨｨ- ﾂ0209ｨｺｨｨ02 010805, 09040709ｨｨ05 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 08ｨｨ09ｨｺｨ 0502 ｨｰｨｨ07ｨ 2 0708ｨｨ ｨｨ01 ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨｨｨ ｨｪｨ 34 %. 0906050202 ｨｰ060006, 0708ｨｨ ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨｨｨ ｨｬｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪ0401 010604 07080207ｨ 08ｨ ｨｰ0609 08ｨｨ09ｨｺ 09060408ｨ 09ｨｰｨ 05 0209050204 0102000205060307 7