132013 000606020902010608 0606ｨｬ 55, 0112 03020506020801010203 080709050606000604020008010603 0007090506060302060301060409 0003050301090600010409 0506040200080905010409 080903060208 030406 03020106040301010200 05020203040408010606 080605090204020208 08 07. 00. 0404050609ｨ, 09. 09. 09ｨｮ08ｨ 09ｨｺ0609ｨ 06ｨｪ09ｨｰｨｨｨｰｨｮｨｰ ｨｬ0201ｨｨｨｺ06-ｨ ｨｨ06050600ｨｨ ﾂ0209ｨｺｨｨ01 070806ｨ 0502ｨｬ 040801, 000609ｨｺ09ｨ ; 050502ｨｺｨｰ0806ｨｪｨｪ04ｨｦ ｨ 01080209: yuliaril@mail.ru 07. 00. 0404050609ｨ, 09. 09. 09ｨｮ08ｨ 09ｨｺ0609ｨ 030609ｨｰ0607ｨｪｨｪ0602 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ02 00000508 0708ｨｨ 0706ｨｪｨｨ0302ｨｪｨｪ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ 0306ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 09ｨｪｨｨ0302ｨｪｨｨ02 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ090506080601ｨ 09 0908020102 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 ｨｬｨｮ05ｨｹｨｰｨｨ0706ｨｰ02ｨｪｨｰｨｪ0401 ｨｬ020402ｨｪ01ｨｨｨｬｨｪ0401 09ｨｰ0806ｨｬｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ (00000508) 0904040409ｨ 0506 ｨｺ08ｨ ｨｰｨｺ06090802ｨｬ02ｨｪｨｪ0602 ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 010605ｨｨ CD73 + -ｨｺ0502ｨｰ06ｨｺ 09 070607ｨｮ050702ｨｨｨｨ, ｨｪ02 0905ｨｨ0707 ｨｪｨ ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 ｨｺ0502ｨｰ06ｨｺ, ｨｪ0209ｨｮｨｴｨｨ01 ｨｪｨ 070609020801ｨｪ0609ｨｰｨｨ 0108ｨｮ00ｨｨ02 ｨｺ06ｨｪ09ｨｰｨｨｨｰｨｮｨｰｨｨ09ｨｪ0402 ｨｬｨ 08ｨｺ020804 (CD90 ｨｨ CD105). 0308ｨｨ 05ｨｰ06ｨｬ 0002ｨｰ0208060002ｨｪｨｪ0609ｨｰｨｹ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 070607ｨｮ050702ｨｨｨｨ 09ｨｪｨｨ03ｨ 05ｨ 09ｨｹ: ｨｨ09 ﾂ0204ｨ 05ｨｨ ｨｺ08ｨｮ07ｨｪ0402 08ｨ 090705ｨ 09ｨｰｨ ｨｪｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ. 03080605ｨｨ000208ｨ ｨｰｨｨ09ｨｪｨ 07 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 00000508 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06 09060408ｨ 09ｨｰｨ 05ｨ ｨｨ 09ｨｰｨ ｨ ｨｨ05ｨｹｨｪ06 09060108ｨ ｨｪ0705ｨ 09ｨｹ 09 ｨｮ09050609ｨｨ0701, 0708ｨｨ ｨｺ06ｨｰ06080401 090601020803ｨ ｨｪｨｨ02 ｨｺｨｨ090506080601ｨ (5 % 02 2 ) ｨ 05ｨｨ04ｨｺ06 ｨｺ ｨｰｨｺｨ ｨｪ020906ｨｬｨｮ ｨｮ080609ｨｪ06. 0308ｨｨ ｨ 06050202 ｨｪｨｨ04ｨｺ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ 06ｨｪｨ 070609ｨｰ020702ｨｪｨｪ06 09ｨｪｨｨ03ｨ 05ｨ 09ｨｹ ｨｪｨ ﾂｨｨｨｪｨ 07 09 3 ｪ4-0006 07ｨ 0909ｨ 03ｨ. 00060408ｨ 09ｨｰｨ ｨｪｨｨ02 07080605ｨｨ000208ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｪ02 090607080609060301ｨ 050609ｨｹ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02ｨｬ 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪｨ ｨｺｨ ｨｰｨ 05ｨｨｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ0204 ｨｰ020506ｨｬ0208ｨ 0404, ﾂｨｰ06 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ090609ｨ 0506 06ｨ 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨｨｨ 06ｨｪｨｺ060002ｨｪｨｪ06ｨｦ ｨｰ08ｨ ｨｪ09000608ｨｬｨ 02ｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ. 030605ｨｪ060002ｨｪ06ｨｬｨｪ04ｨｦ ｨ ｨｪｨ 05ｨｨ04 ｨｮ080609ｨｪ07 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪ0609 00000508 09040709ｨｨ05 010609ｨｰ06090208ｨｪ0602 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ02 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪ0609 02ｨｨｨｺ05ｨｨｨｪ0609 (CCND2 ｨｨ PCNA), 080200ｨｮ0507ｨｰ0608ｨｪ06ｨｦ 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ0204 02ｨｨｨｺ05ｨｨｨｪ-04ｨ 09ｨｨ09ｨｨｨｬ0401 ｨｺｨｨｨｪｨ 04 (CKS2) ｨｨ ｨｨｨｪ00ｨｨｨ ｨｨｨｰ0608ｨ 02ｨｨｨｺ05ｨｨｨｪ-04ｨ 09ｨｨ09ｨｨｨｬ06ｨｦ ｨｺｨｨｨｪｨ 0404 4ｨｨ6(CDKN2C), ｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｺ0502ｨｰ06 ﾂｨｪ04ｨｦ 02ｨｨｨｺ05 0708ｨｨ 09ｨｪｨｨ0302ｨｪｨｨｨｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ090506080601ｨ. 080506 ﾂ02090402 09050609ｨ : ｨｬｨｮ05ｨｹｨｰｨｨ0706ｨｰ02ｨｪｨｰｨｪ0402 ｨｬ020402ｨｪ01ｨｨｨｬｨｪ0402 09ｨｰ0806ｨｬｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ, ｨｨｨｬｨｬｨｮｨｪ060002ｨｪ06ｨｰｨｨ07, ｨｬ06080006050600ｨｨ07, 07080605ｨｨ000208ｨ 02ｨｨ07. 0308ｨｨｨｪ07ｨｰ0402 0906ｨｺ08ｨ ｨｴ02ｨｪｨｨ07:00000508 ｪ ｨｬｨｮ05ｨｹｨｰｨｨ0706ｨｰ02ｨｪｨｰｨｪ0402 ｨｬ020402ｨｪ01ｨｨｨｬｨｪ0402 09ｨｰ0806ｨｬｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ. 0604ｨｮ ﾂ02ｨｪｨｨ02 00ｨｨ04ｨｨ06050600ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｪｨｨ03ｨｨ ｨｬｨｮ05ｨｹｨｰｨｨ0706ｨｰ02ｨｪｨｰｨｪ0401 ｨｬ020402ｨｪ01ｨｨｨｬｨｪ0401 09ｨｰ0806ｨｬｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ (00000508) 0706ｨｺｨ 04ｨ 0506, ﾂｨｰ06 ｨｨ01 ｨｺ06ｨｬ07ｨ 08ｨｰｨｬ02ｨｪｨｰ 09 070609ｨｰｨｪｨ ｨｰｨ 05ｨｹｨｪ06ｨｬ 070208ｨｨ060102 08ｨ 0907080609ｨｰ08ｨ ｨｪ0702ｨｰ0907 ｨｪｨ 090209ｨｹ 060800ｨ ｨｪｨｨ04ｨｬ 09 080204ｨｮ05ｨｹｨｰｨ ｨｰ02 020006 070208ｨｨ09ｨ 09ｨｺｨｮ050708ｨｪ06ｨｦ 0506ｨｺｨ 05ｨｨ04ｨ 02ｨｨｨｨ (Da Silva Meirelles et al., 2006). 01ｨ ｨｨｨ 06050202 09ｨ 03ｨｪ04ｨｬ 00ｨｨ04ｨｨ ﾂ0209ｨｺｨｨｨｬ 00ｨ ｨｺｨｰ060806ｨｬ ｨｬｨｨｨｺ080606ｨｺ08ｨｮ0302ｨｪｨｨ07 09 05ｨｰｨｨ01 ｨｰｨｺｨ ｨｪ02090401 ｨｪｨｨ03ｨ 01 0709050702ｨｰ0907 07ｨ 0802ｨｨｨ 05ｨｹｨｪ0602 01ｨ 090502ｨｪｨｨ02 ｨｺｨｨ090506080601ｨ. 02 ﾂ0209ｨｨ01ｨｪ06, ﾂｨｰ06 07080609ｨｰ08ｨ ｨｪ09ｨｰ0902ｨｪｨｪ0602 08ｨ 09070605060302ｨｪｨｨ02 ｨｬ020402ｨｪ01ｨｨｨｬｨｪ0401 ｨｺ0502ｨｰ06ｨｺ-07080201030209ｨｰ0902ｨｪｨｪｨｨｨｺ0609 06ｨｰｨｪ0609ｨｨｨｰ0205ｨｹｨｪ06 ｨｰ06ｨｺｨ ｨｺ080609ｨｨ, 09ｨｪｨ ｨ 03ｨ 06ｨｴ020006 ｨｨ01 ｨｺｨｨ09050608060106ｨｬ, 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ06 010507 ｨｨ01 00ｨｮｨｪｨｺ02ｨｨｨｦ. 030807ｨｬ0402 ｨｨ04ｨｬ020802ｨｪｨｨ07 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ090506080601ｨ 09 08ｨ 0405ｨｨ ﾂｨｪ0401 060800ｨ ｨｪｨ 01 0706ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ06 09 ｨｺ0609ｨｰｨｪ06ｨｬ ｨｬ06040002 ｨｨｨｬ0202ｨｰ ｨｬ0209ｨｰ06 00ｨｨ0706ｨｺ09ｨｨ07 ｨｨ ﾂｨｰ06 09 ｨｪ02ｨｺ06ｨｰ06080401 06ｨ 05ｨ 09ｨｰ0701 090601020803ｨ ｨｪｨｨ02 ｨｺｨｨ090506080601ｨ ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ 0106090605ｨｹｨｪ06 ｨｪｨｨ04ｨｺｨｨｨｬ ( 4 ｪ1 %) (Chow et al., 2000; 0609ｨ ｨｪ0609, 2012). 00 0108ｨｮ00ｨｨ01 060800ｨ ｨｪｨ 01 ｨｨ ｨｰｨｺｨ ｨｪ0701 090601020803ｨ ｨｪｨｨ02 ｨｺｨｨ090506080601ｨ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06 09ｨ 08ｨｹｨｨ08ｨｮ02ｨｰ: 09 07ｨ 0802ｨｪ01ｨｨｨｬ02 050200ｨｺｨｨ01 ｨｨ 09 ｨｺ08060906ｨｰ06ｨｺ02, ｨ ｨｰｨ ｨｺ0302 09 07ｨ 0802ｨｪ01ｨｨｨｬｨｪ0401 060800ｨ ｨｪｨ 01, ｨｰｨ ｨｺｨｨ01 ｨｺｨ ｨｺ 0702 ﾂ02ｨｪｨｹ, 0706 ﾂｨｺｨｨ ｨｨ 090208010202, 06ｨｪｨ 090609ｨｰｨ 09050702ｨｰ 06ｨｰ 4 0106 14 % (Jungermann, Kietzmann, 1997; Mik et al., 2004; Wild et al., 2005). 00 0108ｨｮ00ｨｨ01 ｨｰｨｺｨ ｨｪ0701 090601020803ｨ ｨｪｨｨ02 ｨｺｨｨ090506080601ｨ 02ｨｴ02 ｨｪｨｨ0302. 06ｨ ｨｺ, 09 0006050609ｨｪ06ｨｬ ｨｬ06040002 06ｨｪ06 ｨｺ060502ｨ 0502ｨｰ0907 06ｨｰ 0.5 0106 7 % (Hemphill et al., 2005), 09 0902ｨｰ ﾂｨ ｨｰｨｺ02 0005ｨ 04ｨ ｨｨ 09ｨｰ02ｨｺ050609ｨｨ01ｨｪ06ｨｬ ｨｰ020502 ｪ 06ｨｰ 1 0106 5 % (Yu, Cringle, 2005). 0306ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 09 03ｨｨ08060906ｨｦ ｨｰｨｺｨ ｨｪｨｨ ｨｬ0403ｨｨ, ｨｪ0209ｨｬ06ｨｰ0807 ｨｪｨ 09040906ｨｺｨｮ06 09ｨｰ020702ｨｪｨｹ 09ｨ 09ｨｺｨｮ050708ｨｨ04ｨ 02ｨｨｨｨ, 090601020803ｨ ｨｪｨｨ02 ｨｺｨｨ090506080601ｨ 090609ｨｰｨ 09050702ｨｰ 06ｨｺ060506 3 % (Matsumoto et al., 2005). 050502010609ｨ ｨｰ0205ｨｹｨｪ06, 00000508 09 09090704ｨｨ 09 ｨｨ01 070208ｨｨ09ｨ 09ｨｺｨｮ050708ｨｪ06ｨｦ 0506ｨｺｨ 05ｨｨ04ｨ 02ｨｨ02ｨｦ 09 ｨｰｨｺｨ ｨｪ02090401 01020706 ｨｨ ｨｮ ﾂｨ 09ｨｰｨｨ02ｨｬ 09 080207ｨ 08ｨ ｨｰｨｨ09ｨｪ0401 07080602020909ｨ 01 ｨｬ0600ｨｮｨｰ 06ｨｺｨ 040409ｨ ｨｰｨｹ0907 09 ｨｮ09050609ｨｨ0701 09 08ｨ 0405ｨｨ ﾂｨｪ04ｨｬ 07ｨ 0802ｨｨｨ 05ｨｹｨｪ04ｨｬ 01ｨ 090502ｨｪｨｨ02ｨｬ ｨｺｨｨ090506080601ｨ. 030605ｨｰ06ｨｬｨｮ, ｨ ｨｮ01ｨｮ ﾂｨｨ 0906090502 ﾂ02ｨｪｨｪ04ｨｬｨｨ 09 08ｨ 0405ｨｨ ﾂｨｪ0402 00ｨｨ04ｨｨ06050600ｨｨ ﾂ0209ｨｺｨｨ02 ｨｨ 07ｨ ｨｰ0600ｨｨ04ｨｨ06050600ｨｨ ﾂ0209ｨｺｨｨ02 0708060202090904 09 060800ｨ ｨｪｨｨ04ｨｬ02, 06ｨｪｨｨ 01060503ｨｪ04 06ｨ 05ｨ 01ｨ ｨｰｨｹ ｨｬ0201ｨ ｨｪｨｨ04ｨｬｨ ｨｬｨｨ 010507 06ｨ 02090702- ﾂ02ｨｪｨｨ07 0705ｨ 09ｨｰｨｨ ﾂｨｪ0609ｨｰｨｨ 0708ｨｨ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｨ 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ 09 ｨｬｨｨｨｺ080606ｨｺ08ｨｮ0302ｨｪｨｨｨｨ. 020906ｨ 04ｨｦ ｨｨｨｪｨｰ02080209 ｨｺ 00000508 ｨｺｨ ｨｺ ｨｪｨ ｨｨｨ 06050202 070208090702ｨｺｨｰｨｨ09ｨｪ06ｨｬｨｮ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｬｨｮ 050502ｨｬ02ｨｪｨｰｨｮ 010507 ｨｰｨｺｨ ｨｪ020906ｨｦ ｨｨｨｪ0302ｨｪ0208ｨｨｨｨ ｨｨ 09060909ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨｬ0201ｨｨ02ｨｨｨｪ04 01ｨｨｨｺｨｰｨｮ02ｨｰ ｨｪ0206ｨ 010601ｨｨｨｬ0609ｨｰｨｹ 07080609020102ｨｪｨｨ07 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ, 0706090907ｨｴ02ｨｪｨｪ0401 060202ｨｪｨｺ02 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ060006 090609ｨｰ0607ｨｪｨｨ07 00000508 09 0708060202090902 ｨｨ01 05ｨｺ0907ｨ ｨｪ09ｨｨｨｨ ex vivo, ｨ ｨｰｨ ｨｺ0302 0607ｨｰｨｨｨｬｨｨ04ｨ 02ｨｨｨｨ 07080602020909ｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 09 020205ｨｹ06 0708ｨｨｨ 05ｨｨ0302ｨｪｨｨ07 ｨｺ ｨｮ09050609ｨｨ07ｨｬ 00ｨｨ04ｨｨ06050600ｨｨ ﾂ0209ｨｺ060006 ｨｬｨｨｨｺ080606ｨｺ08ｨｮ0302ｨｪｨｨ07 05ｨｰｨｨ01 ｨｺ0502ｨｰ06ｨｺ. 000205ｨｹ06 01ｨ ｨｪｨｪ06ｨｦ 08ｨ ｨ 06ｨｰ04 0709050702ｨｰ0907 060202ｨｪｨｺｨ 0905ｨｨ07ｨｪｨｨ07 08ｨ 0405ｨｨ ﾂｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ in vitro ｨｪｨ ｨｬ0608000600ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0602 090609ｨｰ0607ｨｪｨｨ02 00000508 ｨｺ0502ｨｰ06ｨｺ 03ｨｨ08060906ｨｦ ｨｰｨｺｨ ｨｪｨｨ. 00ｨ ｨｰ0208ｨｨｨ 05 ｨｨ ｨｬ02ｨｰ0601ｨｨｨｺｨ 000401020502ｨｪｨｨ02 00000508 070806090601ｨｨ05ｨｨ ｨｨ04 03ｨｨ08060906ｨｦ ｨｰｨｺｨ ｨｪｨｨ, ｨｨ09070605ｨｹ04ｨｮ07 0607ｨｨ09ｨ ｨｪｨｪｨｮ06 ｨｬ02ｨｰ0601ｨｨｨｺｨｮ (Zuk et al., 2001) 09 ｨｬ0601ｨｨ00ｨｨｨｺｨ 02ｨｨ07ｨｬｨｨ (09ｨｮ08ｨ 09ｨｺ0609ｨ ｨｨ 0108., 2009). 06ｨｺｨ ｨｪｨｹ 06ｨ 08ｨ ｨ ｨ ｨｰ0409ｨ 05ｨｨ 0.075%-ｨｪ04ｨｬ 08ｨ 09ｨｰ09060806ｨｬ ｨｺ060505ｨ 0002ｨｪｨ 0404 IA 09 0908020102 a-000300 09 852
13030609ｨｰ0607ｨｪｨｪ0602 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ02 00000508 0708ｨｨ 0706ｨｪｨｨ0302ｨｪｨｪ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ 853 ｨｰ02 ﾂ02ｨｪｨｨ02 35 ｨｬｨｨｨｪ 0708ｨｨ 37 縺05, 04ｨ ｨｰ02ｨｬ 09ｨｮ090702ｨｪ04ｨｨ06 0202ｨｪｨｰ08ｨｨ00ｨｮ00ｨｨ080609ｨ 05ｨｨ 2 08ｨ 04ｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 5 ｨｬｨｨｨｪ 0708ｨｨ 1000 06ｨ /ｨｬｨｨｨｪ, 0609ｨ 0106ｨｺ 080209ｨｮ090702ｨｪ01ｨｨ080609ｨ 05ｨｨ 09 0908020102 a-000300, 090601020803ｨ ｨｴ02ｨｦ 10 % 05ｨｬｨ 08ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨｰ020507 ﾂｨｹ02ｨｦ 090409060806ｨｰｨｺｨｨ, 0904090209ｨ 05ｨｨ 09 ﾂｨ 03ｨｺｨｨ 0302ｨｰ08ｨｨ ｨｨ 0706ｨｬ02ｨｴｨ 05ｨｨ 09 0502 2 -ｨｨｨｪｨｺｨｮｨ ｨ ｨｰ0608 (5 % 0502 2, 95 % 09060401ｨｮ01ｨ ). 05ｨｬ02ｨｪｨｮ 0908020104 070806090601ｨｨ05ｨｨ ﾂ02080204 ｨｺｨ 03010402 72 ﾂ. 0306090502 010609ｨｰｨｨ0302ｨｪｨｨ07 07080201ｨｬ06ｨｪ0609050607 ｨｺ0502ｨｰｨｺｨｨ 07ｨ 0909ｨｨ080609ｨ 05ｨｨ ｨｨ 0706ｨｬ02ｨｴｨ 05ｨｨ 09 ｨｮ09050609ｨｨ07 0706ｨｪｨｨ0302ｨｪｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ, ｨｺ06ｨｰ06080402 09060401ｨ 09ｨ 05ｨｨ ｨｨ09070605ｨｹ04ｨｮ07 ｨｬｨｮ05ｨｹｨｰｨｨ00ｨ 04060904ｨｦ ｨｨｨｪｨｺｨｮｨ ｨ ｨｰ0608 (Sanyo, 080706ｨｪｨｨ07) ｨｨ05ｨｨ 000208ｨｬ02ｨｰｨｨ ﾂｨｪｨｮ06 ｨｺｨ ｨｬ0208ｨｮ (Stemcell Technologies, 050108), ｨｬ0601ｨｨ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪｨｮ06 01ｨ ｨｰ ﾂｨｨｨｺｨ ｨｬｨｨ 01ｨ 090502ｨｪｨｨ07 ｨｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ090506080601ｨ, ｨｨ 07080601ｨｮ09ｨ 05ｨｨ 00ｨ 04060906ｨｦ 09ｨｬ0209ｨｹ06 (95 % N 2,5%0502 2 ) 0106 ｨｮ09ｨｰｨ ｨｪ06090502ｨｪｨｨ07 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｦ ｨｺｨｨ090506080601ｨ 5, 3ｨｨ1%. 020507 ｨ ｨｪｨ 05ｨｨ04ｨ ｨｪｨ 05ｨｨ ﾂｨｨ07 070609020801ｨｪ0609ｨｰｨｪ0401 ｨｬｨ 08ｨｺ02080609 09ｨｮ090702ｨｪ04ｨｨ06 ｨｺ0502ｨｰ06ｨｺ 07020802ｨｪ0609ｨｨ05ｨｨ 09 070806ｨ ｨｨ08ｨｺｨｨ (ｨｪ02 ｨｬ02ｨｪ0202 100 ｨｰ0409. ｨｺ0502ｨｰ06ｨｺ ｨｪｨ 070806ｨ ｨｮ), 0106ｨ ｨ 09050705ｨｨ FITC- ｨｨ05ｨｨ PE-ｨｺ06ｨｪｨｲ0600ｨｨ080609ｨ ｨｪｨｪ0402 ｨ ｨｪｨｰｨｨｨｰ0205ｨ 09 08ｨ 0409020102ｨｪｨｨｨｨ 09060005ｨ 09ｨｪ06 ｨｨｨｪ09ｨｰ08ｨｮｨｺ02ｨｨｨｨ 00ｨｨ08ｨｬ04-070806ｨｨ04090601ｨｨｨｰ020507 (Immunotec, 0808ｨ ｨｪ02ｨｨ07). 06ｨｪｨｺｨｮｨ ｨｨ080609ｨ 05ｨｨ 20 ｨｬｨｨｨｪ 0708ｨｨ 4 縺05 ｨｨ ｨ ｨｪｨ 05ｨｨ04ｨｨ080609ｨ 05ｨｨ 0706 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ06ｨｦ ｨｬ02ｨｰ0601ｨｨｨｺ02 ｨｪｨ 070806ｨｰ06 ﾂｨｪ06ｨｬ 02ｨｨｨｰ060005ｨｮ0608ｨｨｨｬ02ｨｰ0802 Epics XL (Beckman Coulter, 050108). 020202ｨｪｨｺｨｮ ｨｬ06080006050600ｨｨ ﾂ0209ｨｺｨｨ01 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ09ｨｰｨｨｨｺ 00000508 070806ｨｨ04090601ｨｨ05ｨｨ 0708ｨｨ ｨ ｨｪｨ 05ｨｨ0402 ｨｬｨｨｨｺ08060006ｨｰ060008ｨ 00ｨｨｨｦ 0905ｨｮ ﾂｨ ｨｦｨｪ06 0904ｨ 08ｨ ｨｪｨｪ0401 07060502ｨｦ 040802ｨｪｨｨ07, 070605ｨｮ ﾂ02ｨｪｨｪ0401 09 ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨ02ｨｬ 090902ｨｰ0609060006 00ｨ 04060906-ｨｺ06ｨｪｨｰ08ｨ 09ｨｰｨｪ060006 ｨｬｨｨｨｺ080609ｨｺ0607ｨ Leica DM IL (Leica, 010208ｨｬｨ ｨｪｨｨ07) ｨｨ 09060708070302ｨｪｨｪ06ｨｦ 09 ｨｪｨｨｨｬ 020902ｨｰｨｪ06ｨｦ 09ｨｨ010206ｨｺｨ ｨｬ020806ｨｦ (Leica DC500). 03080605ｨｨ000208ｨ ｨｰｨｨ09ｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 00000508 060202ｨｪｨｨ09ｨ 05ｨｨ, ｨ ｨｪｨ 05ｨｨ04ｨｨ08ｨｮ07 ｨｪ02 ｨｬ02ｨｪ0202 5 07060502ｨｦ 09 ｨｺｨ 030106ｨｬ 0005ｨ ｨｺ06ｨｪ02 ｨｺｨ 03010402 24 ﾂ 0706090502 07ｨ 0909ｨｨ080609ｨ ｨｪｨｨ07. 05 0706ｨｬ06ｨｴｨｹ06 0708060008ｨ ｨｬｨｬ04 Sigma ScanPro 5.0 Image Analysis Software (SPSS Inc., 050108) 09 ﾂｨｨｨｰｨ 05ｨｨ ﾂｨｨ090506 ｨｺ0502ｨｰ06ｨｺ ｨｨ 08ｨ 0909 ﾂｨｨｨｰ0409ｨ 05ｨｨ ﾂｨｨ090506 ｨｮ01090602ｨｪｨｨｨｦ 070607ｨｮ050702ｨｨｨｦ (PD) 0706 000608ｨｬｨｮ0502 PD = log 2 N/No, 000102 N 0 ｨｨN ｪ 090606ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06 ｨｪｨ ﾂｨ 05ｨｹｨｪ0602 ｨｨ ｨｺ06ｨｪ02 ﾂｨｪ0602 ﾂｨｨ090506 ｨｺ0502ｨｰ06ｨｺ. 000802ｨｬ07 ｨｮ01090602ｨｪｨｨ07 070607ｨｮ050702ｨｨｨｨ (TD) 060708020102050705ｨｨ 0706 000608ｨｬｨｮ0502 TD = (log 2 2)1 7t/[log 2 (N/N 0 )], 000102 t ｪ 090802ｨｬ07 0708ｨｨ080609ｨｰｨ 070607ｨｮ050702ｨｨｨｨ, N ｪ ﾂｨｨ090506 ｨｺ0502ｨｰ06ｨｺ ﾂ02080204 090802ｨｬ07 t, N 0 ｪ ｨｨ09010601ｨｪ0602 ﾂｨｨ090506 ｨｺ0502ｨｰ06ｨｺ. 08ｨｪｨ 05ｨｨ04 09ｨｰｨ 01ｨｨｨｨ ｨｺ0502ｨｰ06 ﾂｨｪ060006 02ｨｨｨｺ05ｨ 070806090601ｨｨ05ｨｨ ｨｬ02ｨｰ060106ｨｬ 070806ｨｰ06 ﾂｨｪ06ｨｦ 02ｨｨｨｰ060005ｨｮ0608ｨｨｨｬ02ｨｰ08ｨｨｨｨ, ｨｨ09070605ｨｹ04ｨｮ07 ｨｨ0601ｨｨ01 07080607ｨｨ01ｨｨ07, 090907040409ｨ 06ｨｴｨｨｨｦ0907 09 020108. 05ｨｮ090702ｨｪ04ｨｨ06 ｨｺ0502ｨｰ06ｨｺ 07020802ｨｪ0609ｨｨ05ｨｨ 09 070806ｨ ｨｨ08ｨｺｨｨ (ｨｪ02 ｨｬ02ｨｪ0202 200 ｨｰ0409. ｨｪｨ 070806ｨ ｨｮ), 0202ｨｪｨｰ08ｨｨ00ｨｮ00ｨｨ080609ｨ 05ｨｨ 5 ｨｬｨｨｨｪ 0708ｨｨ 1500 06ｨ /ｨｬｨｨｨｪ, ｨｺ 0609ｨ 01ｨｺｨｮ 0106ｨ ｨ 09050705ｨｨ 500 ｨｬｨｺ05 70%-ｨｪ060006 05ｨｰｨｨ050609060006 0907ｨｨ08ｨｰｨ ｨｨ ｨｨｨｪｨｺｨｮｨ ｨｨ080609ｨ 05ｨｨ 1 ﾂ 09 ｨｰ02ｨｬｨｪ06ｨｰ02 0708ｨｨ 4 縺05. 05ｨ ｨｰ02ｨｬ ｨｺ0502ｨｰｨｺｨｨ 070806ｨｬ0409ｨ 05ｨｨ 00060900ｨ ｨｰｨｪ04ｨｬ ｨ ｨｮ00020806ｨｬ, 0202ｨｪｨｰ08ｨｨ00ｨｮ00ｨｨ080609ｨ 05ｨｨ 5 ｨｬｨｨｨｪ 0708ｨｨ 1500 06ｨ /ｨｬｨｨｨｪ, ｨｺ 0609ｨ 01ｨｺｨｮ 0106ｨ ｨ 09050705ｨｨ 500 ｨｬｨｺ05 08ｨ 09ｨｰ090608ｨ, 090601020803ｨ ｨｴ020006 50 ｨｬｨｺ00/ｨｬ05 ｨｨ0601ｨｨ01ｨ 07080607ｨｨ01ｨｨ07 ｨｨ 20 ｨｬｨｺ00/ｨｬ05 040108ｨ 0404 A, ｨｨｨｪｨｺｨｮｨ ｨｨ080609ｨ 05ｨｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 15 ｨｬｨｨｨｪ 0708ｨｨ ｨｺ06ｨｬｨｪｨ ｨｰｨｪ06ｨｦ ｨｰ02ｨｬ070208ｨ ｨｰｨｮ0802 ｨｨ ｨ ｨｪｨ 05ｨｨ04ｨｨ080609ｨ 05ｨｨ. 080605ｨｨ ﾂ0209ｨｰ0906 ｨｺ0502ｨｰ06ｨｺ 09 0607080201020502ｨｪｨｪ06ｨｦ 00ｨ 0402 02ｨｨｨｺ05ｨ 090606ｨｰ0902ｨｰ09ｨｰ09ｨｮ02ｨｰ 090601020803ｨ ｨｪｨｨ06 020108, 060708020102050702ｨｬ06ｨｬｨｮ 0706 ｨｨｨｪｨｰ02ｨｪ09ｨｨ09ｨｪ0609ｨｰｨｨ 0005ｨｮ060802090202ｨｪ02ｨｨｨｨ ｨｺ08ｨ 09ｨｨｨｰ020507, 09090704ｨ ｨｪｨｪ060006 09 020108. 050601020803ｨ ｨｪｨｨ02 020108 ｨｮ0109ｨ ｨｨ09ｨ 02ｨｰ0907 09 00ｨ 0402 G 2 /M, ﾂｨｰ06 01ｨ 02ｨｰ 07ｨｨｨｺ 09 ｨ 0605ｨｹ0302ｨｦ ｨｨｨｪｨｰ02ｨｪ09ｨｨ09ｨｪ0609ｨｰｨｹ06 0005ｨｮ060802090202ｨｪ02ｨｨｨｨ, ﾂ02ｨｬ 00ｨ 0402 G 1, ｨｰ060001ｨ ｨｺｨ ｨｺ 09 S-00ｨ 0402 ｨｺ0502ｨｰｨｺｨｨ 090601020803ｨ ｨｰ 070806ｨｬ0203ｨｮｨｰ06 ﾂｨｪ0602 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 020108 (09ｨｬ. 08ｨ 04010205 00040204ｨｮ05ｨｹｨｰｨ ｨｰ0403, 08ｨｨ09. 3, ｨ ). 020507 0607080201020502ｨｪｨｨ07 ｨｮ080609ｨｪ07 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪｨ ｨｺｨ ｨｰｨ 05ｨｨｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ0204 ｨｰ020506ｨｬ0208ｨ 0404 (htert) ｨｨ04 ｨｺ0502ｨｰ06ｨｺ 09040102050705ｨｨ 040108 09 0706ｨｬ06ｨｴｨｹ06 TRIZOL 09060005ｨ 09ｨｪ06 ｨｨｨｪ09ｨｰ08ｨｮｨｺ02ｨｨｨｨ 00ｨｨ08ｨｬ04-070806ｨｨ04090601ｨｨｨｰ020507. 0402ｨ ｨｺ02ｨｨ06 06ｨ 08ｨ ｨｰｨｪ06ｨｦ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨｨｨ ｨｨ 070605ｨｮ ﾂ02ｨｪｨｨ02 ｨｺ020108 070806ｨｨ04090601ｨｨ05ｨｨ 09 0706ｨｬ06ｨｴｨｹ06 QuantiTect Reverce Transcription Kit 09060005ｨ 09ｨｪ06 ｨｨｨｪ09ｨｰ08ｨｮｨｺ02ｨｨｨｨ 00ｨｨ08ｨｬ04-070806ｨｨ04090601ｨｨｨｰ020507 (Qiagen, 050108). 020507 0607080201020502ｨｪｨｨ07 ｨｮ080609ｨｪ07 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪ0609 0708ｨｨｨｬ02ｨｪ0705ｨｨ ｨｺ06ｨｬ070502ｨｺｨｰ 0802ｨ 0002ｨｪｨｰ0609 010507 070605ｨｨｨｬ0208ｨ 04ｨｪ06ｨｦ 020207ｨｪ06ｨｦ 0802ｨ ｨｺ02ｨｨｨｨ, 09 ｨｺ06ｨｰ060804ｨｦ 0901060107ｨｰ: 09ｨｬ0209ｨｹ 01020406ｨｺ09ｨｨ08ｨｨｨ 06ｨｪｨｮｨｺ050206ｨｰｨｨ010609, 0802ｨｺ06ｨｬｨ ｨｨｨｪｨ ｨｪｨｰｨｪｨ 07 020108-070605ｨｨｨｬ0208ｨ 04ｨ HotStarTaq, MgCl 2 ｨｨ ｨｺ020108, ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 ｨｺ06ｨｰ060806ｨｦ 010507 0601ｨｪ06ｨｦ 0802ｨ ｨｺ02ｨｨｨｨ 090609ｨｰｨ 0905070506 0.5 ｨｬｨｺ00. 020507 060202ｨｪｨｺｨｨ ｨｮ080609ｨｪ07 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪ0609 ｨｨ09070605ｨｹ040609ｨ 05ｨｨ 07ｨ 0804 0708ｨ ｨｦｨｬ02080609, 090606ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴｨｨ02 ﾂ02ｨｰ040802ｨｬ 000608ｨｬｨ ｨｬ 0002ｨｪｨ htert. 020202ｨｪｨｺｨｮ 01ｨｨ0000020802ｨｪ02ｨｨｨ 05ｨｹｨｪ06ｨｦ 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪ0609 00000508, ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ0401 0708ｨｨ 090601020803ｨ ｨｪｨｨｨｨ 02 2 09 0908020102 20 ｨｨ 5 %, 070806090601ｨｨ05ｨｨ ｨｪｨ 2-ｨｬ 07ｨ 0909ｨ 0302 09 0706ｨｬ06ｨｴｨｹ06 ｨｪｨ ｨ 0608ｨ Human- Ref-8 (Illumina, 050108). 020507 090401020502ｨｪｨｨ07 040108 ｨｨ09070605ｨｹ040609ｨ 05ｨｨ 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ04ｨｦ ｨｬ02ｨｰ0601 09 0706ｨｬ06ｨｴｨｹ06 TRIZOL 09060005ｨ 09ｨｪ06 ｨｨｨｪ09ｨｰ08ｨｮｨｺ02ｨｨｨｨ 00ｨｨ08ｨｬ04-070806ｨｨ04090601ｨｨｨｰ020507. 00 070605ｨｮ ﾂ02ｨｪｨｪ0401 06ｨ 08ｨ 0402ｨ 01 ｨｺ0502ｨｰ06ｨｺ 060708020102050705ｨｨ 090601020803ｨ ｨｪｨｨ02 040108 09 0706ｨｬ06ｨｴｨｹ06 Nanodrop, 0706090502 ﾂ020006 200 ｨｪ00 040108 ｨ ｨｬ0705ｨｨ00ｨｨ02ｨｨ080609ｨ 05ｨｨ 09 0706ｨｬ06ｨｴｨｹ06 ｨｪｨ ｨ 0608ｨ Illumina(r) TotalPrep6ｾ4 RNA Amplification Kit (Ambion, 050108). 08ｨｬ0705ｨｨ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪｨｮ06 040108 07060109020800ｨ 05ｨｨ 00ｨｨｨ 08ｨｨ01ｨｨ04ｨ 02ｨｨｨｨ ｨｪｨ ｨｬｨｨｨｺ0806 ﾂｨｨ07ｨ 01 Human-Ref8 gene expression array (Illumina, 050108) 09060005ｨ 09ｨｪ06 070806ｨｰ06ｨｺ0605ｨｮ 00ｨｨ08ｨｬ04-070806ｨｨ04090601ｨｨｨｰ020507. 03060109 ﾂ02ｨｰ ｨｨ ｨ ｨｪｨ 05ｨｨ04 070605ｨｮ ﾂ02ｨｪｨｪ0401 01ｨ ｨｪｨｪ0401 070806ｨｨ04090601ｨｨ05ｨｨ 09 0706ｨｬ06ｨｴｨｹ06 0708060008ｨ ｨｬｨｬｨｪ060006 06ｨ 02090702 ﾂ02ｨｪｨｨ07 GenomeStudio software (Illumina, 050108) 09 ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨ02ｨｬ 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ- ﾂ0209ｨｺ060006 ｨｬ0601ｨｮ0507 010507 ｨ ｨｪｨ 05ｨｨ04ｨ 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪ0609. 04ｨ 0405ｨｨ ﾂｨｨ07 09 ﾂｨｨｨｰｨ 05ｨｨ09ｨｹ 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨｨ 04ｨｪｨ ﾂｨｨｨｬ04ｨｬｨｨ 0708ｨｨ P 1 7 0.05. 020507 070605ｨｮ ﾂ02ｨｪｨｨ07 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨｨ 04ｨｪｨ ﾂｨｨｨｬ0401 080204ｨｮ05ｨｹｨｰｨ ｨｰ0609 090902 05ｨｺ09070208ｨｨｨｬ02ｨｪｨｰ04 07080609020102ｨｪ04 ｨｬｨｨｨｪｨｨｨｬｨｮｨｬ 09 ｨｰ080201 ｨｪ0204ｨ 09ｨｨ09ｨｨｨｬ0401 070609ｨｰ0608ｨ 01. 020507 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 06ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ 080204ｨｮ05ｨｹｨｰｨ ｨｰ0609 ｨｨ09070605ｨｹ040609ｨ 05ｨｨ 0708060008ｨ ｨｬｨｬｨｮ 00Excel03 010507 WinXP, 010609ｨｰ06090208ｨｪ0609ｨｰｨｹ 08ｨ 0405ｨｨ ﾂｨｨｨｦ ｨｬ020301ｨｮ 0109ｨｮｨｬ07 0008ｨｮ0707ｨ ｨｬｨｨ 01ｨ ｨｪｨｪ0401 060202ｨｪｨｨ09ｨ 05ｨｨ 09 0706ｨｬ06ｨｴｨｹ06 ｨｪ0207ｨ 08ｨ ｨｬ02ｨｰ08ｨｨ ﾂ0209ｨｺ060006 ｨｺ08ｨｨｨｰ0208ｨｨ07 00ｨ ｨｪｨｪｨ ｪ07ｨｨｨｰｨｪｨｨ 0708ｨｨ 0904ｨ 08ｨ ｨｪｨｪ06ｨｬ ｨｮ080609ｨｪ02 04ｨｪｨ ﾂｨｨｨｬ0609ｨｰｨｨ P 1 7 0.05. 00 08ｨ ｨ 06ｨｰ02 ｨｨ09070605ｨｹ040609ｨ 05ｨｨ 09050201ｨｮ06ｨｴｨｨ02 0802ｨ ｨｺｨｰｨｨ0904: 09080201ｨｮ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 a-000300 (MP Biomedicals, 050108), L-0005ｨｮｨｰｨ ｨｬｨｨｨｪ, 08ｨ 09ｨｰ090608 ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺ0609 09 0.85%-ｨｪ06ｨｬ 090605020906ｨｬ ｨ ｨｮ00020802, 090601020803ｨ ｨｴ02ｨｬ 10 000 0201./ｨｬ05 0702ｨｪｨｨ02ｨｨ0505ｨｨｨｪｨ ｨｨ 10 000 ｨｬｨｺ00/ｨｬ05 09ｨｰ080207ｨｰ06ｨｬｨｨ02ｨｨｨｪｨ (03ｨ ｨｪ06ｨｺ06, 04060909ｨｨ07, ｨｨ05ｨｨ 09ｨｨ06050606, 04060909ｨｨ07), 05ｨｬｨ 08ｨｨ06ｨｪｨ 05ｨｹｨｪｨｮ06 ｨｰ020507 ﾂｨｹ06 090409060806ｨｰｨｺｨｮ (Hyclone, 050108), 20 ｨｬ00 00060900ｨ ｨｰｨｪ04ｨｦ ｨ ｨｮ000208 (09ｨｨ060506ｨｰ, 04060909ｨｨ07), 07ｨ 08ｨ 000608ｨｬｨ 05ｨｹ010200ｨｨ01 (Merck, 010208ｨｬｨ ｨｪｨｨ07), 08ｨ 09ｨｰ090608 ｨｰ08ｨｨ0709ｨｨｨｪｨ ｨｨ 06020608 09 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ07ｨｬｨｨ 0902ｨｴ0209ｨｰ09 0.5 ｨｨ 0.2 00/05 090606ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06 (Gibco, 050108 ｨｨ05ｨｨ Sigma, 050108), 0.15%-ｨｪ04ｨｦ 08ｨ 09ｨｰ090608 ｨｺ060505ｨ 0002ｨｪｨ 0404 ｨｰｨｨ07ｨ IA (Sigma, 050108), ｨｬ06ｨｪ06ｨｺ0506ｨｪｨ 05ｨｹｨｪ0402 ｨ ｨｪｨｰｨｨｨｰ0205ｨ 070806ｨｰｨｨ09 ｨ ｨｪｨｰｨｨ0002ｨｪ0609 CD31, CD73, CD90 ｨｨ CD105, ｨｺ06ｨｪｨｲ0600ｨｨ080609ｨ ｨｪｨｪ0402 09 0005ｨｮ060802090202ｨｨｨｪｨｨ0406ｨｰｨｨ0602ｨｨｨ ｨｪｨ ｨｰ06ｨｬ (FITC) ｨｨ05ｨｨ 00ｨｨｨｺ060508ｨｨｨｰ08ｨｨｨｪ06ｨｬ (PE), ｨｨ 090606ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴｨｨ02 ｨｨ0406ｨｰｨｨ07ｨｨ ﾂ0209ｨｺｨｨ02 ｨｺ06ｨｪｨｰ080605ｨｨ (Immunotec, 0808ｨ ｨｪ02ｨｨ07). 040204ｨｮ05ｨｹｨｰｨ ｨｰ04 06ｨｬｨｬｨｮｨｪ060002ｨｪ06ｨｰｨｨ07ｨｨ ﾂ0209ｨｺｨｨｨｦ 07080600ｨｨ05ｨｹ 00000508, ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ0401 09 ｨｮ09050609ｨｨ0701 08ｨ 0405ｨｨ ﾂｨｪ060006 090601 02 08 03 ｨ ｨｪ ｨｨ 07 ｨｺ ｨｨ 09 05 06 08 06 01 ｨ. 01ｨ 070609020801ｨｪ0609ｨｰｨｨ ｨｨ0909050201ｨｮ02ｨｬ0401 ｨｺ0502ｨｰ06ｨｺ 09040709ｨｨ05ｨｨ 080701 ｨ ｨｪｨｰｨｨ0002ｨｪ0609, ｨｺ06ｨｰ06080402 080200ｨｮ05ｨｨ08ｨｮ06ｨｰ ｨｰｨ ｨｺｨｨ02 0708060202090904, ｨｺｨ ｨｺ ｨ 01000204ｨｨ07, ｨｬｨｨ0008ｨ 02ｨｨ07, ｨｺ06080202020702ｨｨ07 ｨｨ 0702080201ｨ ﾂｨ 09ｨｨ00ｨｪｨ 05ｨ 09ｨｪｨｮｨｰ08ｨｹ ｨｺ0502ｨｰｨｺｨｨ, ｨｨ 000608ｨｬｨｨ08ｨｮ06ｨｰ 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ04ｨｦ ｨｨｨｬｨｬｨｮｨｪ060002ｨｪ06ｨｰｨｨ07ｨｨ ﾂ0209ｨｺｨｨｨｦ 07080600ｨｨ05ｨｹ 080204ｨｨ0102ｨｪｨｰｨｪ0401 00000508 03ｨｨ08060906ｨｦ ｨｰｨｺｨ ｨｪｨｨ. 00ｨｨｨｰ060005ｨｮ0608ｨｨｨｬ02ｨｰ08ｨｨ ﾂ0209ｨｺ0602 ｨｨ09090502010609ｨ ｨｪｨｨ02 0706ｨｺｨ 04ｨ 0506, ﾂｨｰ06 01ｨ ｨｪｨｪ04ｨｦ 07080600ｨｨ05ｨｹ, ｨｨ09070605ｨｹ04ｨｮ02ｨｬ04ｨｦ 09 ｨｪｨ 09ｨｰ0607ｨｴ0202 090802ｨｬ07 010507 ｨｨ0102ｨｪｨｰｨｨ00ｨｨｨｺｨ 02ｨｨｨｨ 00000508 (CD73, CD90 ｨｨ CD105), ｨｪ02 ｨｨ04ｨｬ02ｨｪ07050907. 0308ｨｨ 05ｨｰ06ｨｬ ｨｺ0502ｨｰｨｺｨｨ ｨｪ02 ｨｪ020905ｨｨ ｨ ｨｪｨｰｨｨ0002ｨｪｨ CD31, 090906ｨｦ09ｨｰ0902ｨｪｨｪ060006 05ｨｪ0106ｨｰ0205ｨｨｨ 05ｨｹｨｪ04ｨｬ ｨｺ0502ｨｰｨｺｨ ｨｬ. 08ｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ02 0708ｨｨ 090601020803ｨ ｨｪｨｨｨｨ 02 2 5, 3 ｨｨ05ｨｨ 1 % ｨｪｨ 1-ｨｬ 07ｨ 0909ｨ 0302 090607080609060301ｨ 050609ｨｹ 09ｨｪｨｨ0302ｨｪｨｨ02ｨｬ 010605ｨｨ CD73 + -ｨｺ0502ｨｰ06ｨｺ 07080607060802ｨｨ06ｨｪｨ 05ｨｹｨｪ06 ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ06 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ090506080601ｨ
07. 00. 0404050609ｨ, 09. 09. 09ｨｮ08ｨ 09ｨｺ0609ｨ 854 06ｨ ｨ 05ｨｨ02ｨ 1 030609020801ｨｪ0609ｨｰｨｪ0402 ｨｬｨ 08ｨｺ020804 09 00000508 1 ｪ2-0006 07ｨ 0909ｨ 03ｨ, ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ0401 0708ｨｨ 08ｨ 0405ｨｨ ﾂｨｪ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ 03ｨ 0909ｨ 03 00ｨ 08ｨｺ020804 02060507 ｨｺ0502ｨｰ06ｨｺ ( %), ｨｪ0209ｨｮｨｴｨｨ01 ｨｬｨ 08ｨｺ020804 00000508, 0708ｨｨ 08ｨ 04ｨｪ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ 022 20 % 5% 3% 1% 1 CD73 CD90 CD105 87.8 ) 6.4 92.8 ) 4.0 89.6 ) 4.1 76.9 ) 4.6 88.4 ) 4.4 80.4 ) 12.1 69.1 ) 5.8ｨ 73.7 ) 5.4 79.4 ) 9.8 53.3 ) 7.6ｨ 82.2 ) 4.4 87.2 ) 5.5 2 CD73 CD90 CD105 97.6 ) 1.7 97.8 ) 1.5 96.6 ) 0.8 97.4 ) 0.7 97.8 ) 0.4 94.1 ) 5.0 97.3 ) 2.4 92.3 ) 2.7 91.4 ) 6.1 96.7 ) 1.5 95.8 ) 1.2 90.3 ) 8.7 ｨ 020609ｨｰ06090208ｨｪ0602 06ｨｰ05ｨｨ ﾂｨｨ02 06ｨｰ 04ｨｪｨ ﾂ02ｨｪｨｨｨｦ 0708ｨｨ 20%-ｨｪ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ 022, P 7 0.05. 09 0908020102, ｨｪ02 0904040409ｨ 07 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 0108ｨｮ00ｨｨ01 ｨｨ0909050201ｨｮ02ｨｬ0401 ｨｬｨ 08ｨｺ02080609. 02ｨ 05ｨｹｨｪ02ｨｦ030202 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ02 00000508 09 ｨｮ09050609ｨｨ0701 0706ｨｪｨｨ0302ｨｪｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 ｨｰ080201 07ｨ 0909ｨ 0302ｨｦ ｨｪ02 0905ｨｨ070506 ｨｪｨ 01060506 CD105+- ｨｨ CD90+-ｨｺ0502ｨｰ06ｨｺ ｨｨ 0708ｨｨ090601ｨｨ0506 ｨｺ 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨ06 ｨｺ0605ｨｨ ﾂ0209ｨｰ09ｨ CD73+-ｨｺ0502ｨｰ06ｨｺ 0106 ｨｨ09010601ｨｪ060006 ｨｮ080609ｨｪ07 (ｨｰｨ ｨ 05. 1). 0005ｨｨ07ｨｪｨｨ02 08ｨ 0405ｨｨ ﾂｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ09050608 06 01 ｨ ｨｪ ｨ ｨｬ 06 08 00 06 05 06 00 ｨｨ 06 00 00 05 08. 08ｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ02 09 ｨｮ09050609ｨｨ0701 08ｨ 0405ｨｨ ﾂｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ 09040709ｨｨ0506 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0402 ｨｬ06080006050600ｨｨ ﾂ0209ｨｺｨｨ02 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 00000508. 00 ｨｮ09050609ｨｨ0701 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ (20 %) 06ｨｰｨｬ02 ﾂｨ 05ｨｨ 09040906ｨｺｨｮ06 09ｨｰ020702ｨｪｨｹ 0002ｨｰ0208060002ｨｪｨｪ0609ｨｰｨｨ 070607ｨｮ050702ｨｨｨｦ 00000508, ｨｺ06ｨｰ0608ｨ 07 090408ｨ 03ｨ 05ｨ 09ｨｹ 09 0708ｨｨ09ｨｮｨｰ09ｨｰ09ｨｨｨｨ 09 ｨｺｨｮ05ｨｹｨｰｨｮ0802 ｨｺ0502ｨｰ06ｨｺ 08ｨ 04ｨｪ0401 ｨｰｨｨ070609, 06ｨｰ05ｨｨ ﾂｨ 06ｨｴｨｨ010907 0706 ｨｬ06080006050600ｨｨｨｨ. 000603ｨｪ06 ｨ 040506 0904010205ｨｨｨｰｨｹ ｨｰ0802ｨｮ000605ｨｹｨｪ0402 ｨｨ05ｨｨ 0409020401 ﾂｨ ｨｰ0402 ｨｺ0502ｨｰｨｺｨｨ (40 ｪ60 ｨｬｨｺｨｬ), 09020802ｨｰ02ｨｪ0609ｨｨ01ｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ (60 ｪ100 ｨｬｨｺｨｬ) ｨｨ 06 ﾂ02ｨｪｨｹ ｨｺ08ｨｮ07ｨｪ0402 (0106 200 ｨｬｨｺｨｬ) 09 ｨ 0605ｨｹ03ｨｨｨｬ ｨｺ0605ｨｨ ﾂ0209ｨｰ0906ｨｬ 06ｨｰ080609ｨｰｨｺ0609. 0906050202 0105ｨｨｨｰ0205ｨｹｨｪ0602 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ02 (4 07ｨ 0909ｨ 03ｨ ) 0904040409ｨ 0506 070609ｨｰ020702ｨｪｨｪ0602 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 010605ｨｨ ｨｺ08ｨｮ07ｨｪ0401 08ｨ 090705ｨ 09ｨｰｨ ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ (200 ｨｬｨｺｨｬ ｨｨ ｨ 06050202) ｨｨ 0906ｨｺ08ｨ ｨｴ02ｨｪｨｨ02 010605ｨｨ ｨｺ0502ｨｰ06ｨｺ ｨｺ05ｨ 0909ｨｨ ﾂ0209ｨｺ06ｨｦ 09020802ｨｰ02ｨｪ0609ｨｨ01ｨｪ06ｨｦ 000608ｨｬ04 (60 ｪ 100 ｨｬｨｺｨｬ) (08ｨｨ09. 1, ｨ, ｨ ). 07ｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ090506080601ｨ 09 0908020102 ｨｺ06 2-ｨｬｨｮ 07ｨ 0909ｨ 03ｨｮ 0906ｨｺ08ｨ ｨｴｨ 0506 070607ｨｮ050702ｨｨ06 ｨｺ08ｨｮ07ｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ｨｨ 0907060906ｨ 09ｨｰ090609ｨ 0506 07080206ｨ 05ｨ 01ｨ ｨｪｨｨ06 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ0607060106ｨ ｨｪ0401 ｨｺ0502ｨｰ06ｨｺ (08ｨｨ09. 1, 09, 00, 03). 00 ｨｮ09050609ｨｨ0701 1%-ｨｪ060006 090601020803ｨ ｨｪｨｨ07 022 07060709050705ｨｨ09ｨｹ ｨｪ02ｨ 0605ｨｹ03ｨｨ02 ｨｺ0502ｨｰｨｺｨｨ 08ｨ 04ｨｬ020806ｨｬ 40 ｪ60 ｨｬｨｺｨｬ. 02ｨ 05ｨｹｨｪ02ｨｦ030202 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ02 00000508 (3 ｪ4-ｨｦ 07ｨ 0909ｨ 03) 09 ｨｮ09050609ｨｨ0701 0706ｨｪｨｨ0302ｨｪｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ 0907060906ｨ 09ｨｰ090609ｨ 0506 07060101020803ｨ ｨｪｨｨ06 ｨｬ06080006050600ｨｨ ﾂ0209ｨｺ06ｨｦ 0006ｨｬ060002ｨｪｨｪ0609ｨｰｨｨ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 070607ｨｮ050702ｨｨｨｨ. 0308ｨｨ ｨｮ09050609ｨｨ0701, ｨｪｨ ｨｨｨ 06050202 0708ｨｨｨ 05ｨｨ0302ｨｪｨｪ0401 ｨｺ ｨｰｨｺｨ ｨｪ020906ｨｬｨｮ ｨｮ080609ｨｪ06 ｨｺｨｨ090506080601ｨ (3 ｪ5 %), 09060108ｨ ｨｪ0705ｨ 09ｨｹ 0601ｨｪ06080601ｨｪ0609ｨｰｨｹ ｨｺ0502ｨｰ06ｨｺ 09 ｨｺｨｮ05ｨｹｨｰｨｮ0802, ｨｰ060001ｨ ｨｺｨ ｨｺ 0708ｨｨ ｨｺ08ｨ ｨｦｨｪ02 ｨｪｨｨ04ｨｺ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ ｨｪｨ 4-ｨｬ 07ｨ 0909ｨ 0302 07060709050705ｨｨ09ｨｹ 08ｨ 090705ｨ 09ｨｰｨ ｨｪｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ 09 ｨ 0605ｨｹ03ｨｨｨｬ ｨｺ0605ｨｨ ﾂ0209ｨｰ0906ｨｬ 06ｨｰ080609ｨｰｨｺ0609, 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ0402 010507 ｨｺｨｮ05ｨｹｨｰｨｮ08 00000508 0708ｨｨ 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ. 0005ｨｨ07ｨｪｨｨ02 08ｨ 0405ｨｨ ﾂｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ ｨｪｨ 07080605ｨｨ000208ｨ ｨｰｨｨ09ｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 00 00 05 08. 08ｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ02 09 ｨｮ09050609ｨｨ0701 0706ｨｪｨｨ0302ｨｪｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 6 09ｨｮｨｰ (1-ｨｦ 07ｨ 0909ｨ 03) ｨｪ02 0708ｨｨ090601ｨｨ0506 ｨｺ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ06 07080605ｨｨ000208ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 00000508 03ｨｨ08060906ｨｦ ｨｰｨｺｨ ｨｪｨｨ. ﾁｨｨ090506 ｨｮ01090602ｨｪｨｨｨｦ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 070607ｨｮ050702ｨｨｨｨ ｨｪ02 ｨｬ02ｨｪ07050609ｨｹ ｨｨ 090606ｨｰ0902ｨｰ09ｨｰ090609ｨ 0506 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ04ｨｬ 04ｨｪｨ - 04ｨｨ09. 1. 0006080006050600ｨｨ07 00000508 0708ｨｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨｨｨ 09 ｨｮ09050609ｨｨ0701 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ 20 (ｨ, ｨ ), 5 (09, 00), 3 (01, 02) ｨｨ 1 (03, 04) %. 0308020109ｨｰｨ 090502ｨｪ04 ｨｺ0502ｨｰｨｺｨｨ 2-0006 (ｨ, 09, 01, 03) ｨｨ 4-0006 (ｨ, 00, 02, 04) 07ｨ 0909ｨ 03ｨ ; 00ｨ 04060904ｨｦ ｨｺ06ｨｪｨｰ08ｨ 09ｨｰ; ｨｬｨ 0903ｨｰｨ ｨ ｨｪ0402 06ｨｰ080204ｨｺｨｨ ｪ 100 ｨｬｨｺｨｬ.
13030609ｨｰ0607ｨｪｨｪ0602 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ02 00000508 0708ｨｨ 0706ｨｪｨｨ0302ｨｪｨｪ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ 855 ﾂ02ｨｪｨｨ07ｨｬ 09 ｨｮ09050609ｨｨ0701 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ060006 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 (20 % 02 2 ) (08ｨｨ09. 2, ｨ ). 0308ｨｨ 05ｨｰ06ｨｬ 090802ｨｬ07 ｨｮ01090602ｨｪｨｨ07 070607ｨｮ050702ｨｨｨｨ ｨｰｨ ｨｺ0302 09ｨ 08ｨｹｨｨ080609ｨ 0506 09 ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0401 070802010205ｨ 01 06ｨｰ 73 ｪ79 ﾂ 0708ｨｨ 20ｨｨ5%02 2 0106 64 ｪ67 ﾂ 0708ｨｨ 3ｨｨ1%02 2 (ｨｰｨ ｨ 05. 2). 02ｨ 05ｨｹｨｪ02ｨｦ030202 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ02 00000508 09 ｨｮ09050609ｨｨ0701 0706ｨｪｨｨ0302ｨｪｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 2-0006 07ｨ 0909ｨ 03ｨ 06ｨｺｨ 040409ｨ 0506 08ｨ 09ｨｪ0604ｨｪｨ ﾂｨｪ0602 09ｨｰｨｨｨｬｨｮ05ｨｨ08ｨｮ06ｨｴ0202 ｨｺ0502ｨｰ06 ﾂｨｪｨｮ06 07080605ｨｨ000208ｨ 02ｨｨ06 0102ｨｦ09ｨｰ09ｨｨ02 ｨｪ0204ｨ 09ｨｨ09ｨｨｨｬ06 06ｨｰ 09ｨｰ020702ｨｪｨｨ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ07 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ090506080601ｨ ｨｨ 0907060906ｨ 09ｨｰ090609ｨ 0506 0906ｨｺ08ｨ ｨｴ02ｨｪｨｨ06 090802ｨｬ02ｨｪｨｨ ｨｮ01090602ｨｪｨｨ07 070607ｨｮ050702ｨｨｨｨ 0106 56 ｪ54 ﾂ. ﾁｨｨ090506 ｨｮ01090602ｨｪｨｨ07 070607ｨｮ050702ｨｨｨｨ 09 ｨｮ09050609ｨｨ0701 0706ｨｪｨｨ0302ｨｪｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ 09060408ｨ 09ｨｰｨ 0506 09 1.3 08ｨ 04ｨ 0706 0908ｨ 09ｨｪ02ｨｪｨｨ06 0906 04ｨｪｨ ﾂ02ｨｪｨｨ07ｨｬｨｨ ｨｪｨ 1-ｨｬ 07ｨ 0909ｨ 0302. 06060001ｨ ｨｺｨ ｨｺ 09 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ0401 ｨｮ09050609ｨｨ0701 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 07080605ｨｨ000208ｨ ｨｰｨｨ09ｨｪｨ 07 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｮｨｬ02ｨｪｨｹ03ｨ 05ｨ 09ｨｹ, 06 ﾂ02ｨｬ 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ090609ｨ 05ｨｨ 1.5-ｨｺ08ｨ ｨｰｨｪ0602 09ｨｪｨｨ0302ｨｪｨｨ02 ﾂｨｨ0905ｨ ｨｮ01090602ｨｪｨｨ07 ｨｨ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0602 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 090802ｨｬ02ｨｪｨｨ ｨｮ01090602ｨｪｨｨ07 070607ｨｮ050702ｨｨｨｨ. 0808ｨｨ090402 07080605ｨｨ000208ｨ 02ｨｨｨｨ 00000508 ｨｪｨ 2-ｨｬ 07ｨ 0909ｨ 0302 0708ｨｨ 1 ｪ5 % 02 2 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06 06ｨｰ05ｨｨ ﾂｨ 05ｨｨ09ｨｹ 06ｨｰ ｨｺ08ｨｨ0906ｨｦ 07080605ｨｨ000208ｨ 02ｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ 09 ｨｺ06ｨｪｨｰ08060502. 000802ｨｬ07 05ｨ 00-00ｨ 0404, 09 ｨｰ02 ﾂ02ｨｪｨｨ02 ｨｺ06ｨｰ060806ｨｦ ｨｪ02 070806ｨｨ09010601ｨｨ0506 ｨｮ01090602ｨｪｨｨ07 ｨｺ0502ｨｰ06ｨｺ, 0906ｨｺ08ｨ ｨｰｨｨ050609ｨｹ 0106 ｨｪ0209ｨｺ0605ｨｹｨｺｨｨ01 ﾂｨ 090609, 0706090502 ﾂ020006 ｨｪｨ ﾂｨｨｨｪｨ 05ｨ 09ｨｹ 00ｨ 04ｨ ｨ ｨｺｨｰｨｨ09ｨｪ06ｨｦ 07080605ｨｨ000208ｨ 02ｨｨｨｨ. 0308ｨｨ 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ06ｨｬ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨｨｨ 05ｨ 00-00ｨ 04ｨ 0105ｨｨ05ｨ 09ｨｹ ｨｪ02 ｨｬ02ｨｪ0202 2 09ｨｮｨｰ ｨｨ 09ｨｬ02ｨｪ0705ｨ 09ｨｹ 00ｨ 0406ｨｦ ｨｬ02010502ｨｪｨｪ060006 080609ｨｰｨ ｨｺｨｮ05ｨｹｨｰｨｮ0804 (08ｨｨ09. 2, ｨ ). 00 080204ｨｮ05ｨｹｨｰｨ ｨｰ02 ﾂｨｨ090506 00000508 09 ｨｺｨｮ05ｨｹｨｰｨｮ08ｨ 01, 05ｨｺ090706ｨｪｨｨ080609ｨ ｨｪｨｪ0401 0708ｨｨ 0706ｨｪｨｨ0302ｨｪｨｪ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ, ｨ 06050202 ﾂ02ｨｬ 09 3 08ｨ 04ｨ 070802090403ｨ 0506 ﾂｨｨ090506 ｨｺ0502ｨｰ06ｨｺ 09 ｨｺ06ｨｪｨｰ08060502. 010209ｨｬ06ｨｰ0807 ｨｪｨ 090408ｨ 0302ｨｪｨｪ0602 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 07080605ｨｨ000208ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｨ 0906ｨｺ08ｨ ｨｴ02ｨｪｨｨ02 05ｨ 00-00ｨ 0404 09 ｨｮ09050609ｨｨ0701 0706ｨｪｨｨ0302ｨｪｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ, ｨｪ02 090407090502ｨｪ06 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0401 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ 090606ｨｰｨｪ060302ｨｪｨｨ07 ｨｺ0502ｨｰ06ｨｺ, ｨｪｨ 01060107ｨｴｨｨ010907 09 ｨｰ06ｨｦ ｨｨ05ｨｨ ｨｨｨｪ06ｨｦ 00ｨ 0402 ｨｺ0502ｨｰ06 ﾂｨｪ060006 02ｨｨｨｺ05ｨ (08ｨｨ09. 3, ｨ ). 080605ｨｨ ﾂ0209ｨｰ0906 ｨｺ0502ｨｰ06ｨｺ 09 S-00ｨ 0402 ｨｮ090205ｨｨ ﾂｨｨ09ｨ 050609ｨｹ 09 3 0106 5 ｪ6 %, ｨ 09 G 2 /M00ｨ 04ｨ 01 ｪ0917010619%. 3-ｨｦ ｨｨ 4-ｨｦ 07ｨ 0909ｨ 03ｨｨ 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ040609ｨ 05ｨｨ09ｨｹ 070609ｨｰ020702ｨｪｨｪ04ｨｬ 09ｨｪｨｨ0302ｨｪｨｨ02ｨｬ 07080605ｨｨ000208ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 00000508 ｨｪ0204ｨ 09ｨｨ09ｨｨｨｬ06 06ｨｰ 090601020803ｨ ｨｪｨｨ07 02 2 09 0908020102 (08ｨｨ09. 2, ｨ ). 0201ｨｪｨ ｨｺ06 ｨｺ 4-ｨｬｨｮ 07ｨ 0909ｨ 03ｨｮ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 ｨｪｨ ｨｨｨ 0605ｨｹ030202 ﾂｨｨ090506 ｨｮ01090602ｨｪｨｨ07 ｨｨ, 090502010609ｨ ｨｰ0205ｨｹｨｪ06, ｨｪｨ ｨｨｨｬ02ｨｪｨｹ030202 090802ｨｬ07 ｨｮ01090602ｨｪｨｨ07 ｨ 040506 ｨｮ ｨｺ0502ｨｰ06ｨｺ, 05ｨｺ090706ｨｪｨｨ080609ｨ ｨｪｨｪ0401 09 ｨｮ09050609ｨｨ0701, 0708ｨｨｨ 05ｨｨ0302ｨｪｨｪ0401 ｨｺ 00ｨｨ04ｨｨ06050600ｨｨ ﾂ0209ｨｺｨｨｨｬ, 0708ｨｨ ｨｺ06ｨｰ06080401 ｨｮ08060902ｨｪｨｹ 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ 090609ｨｰｨ 09050702ｨｰ 5 %. 08 09 ｨｺｨｮ05ｨｹｨｰｨｮ08ｨ 01, 05ｨｺ090706ｨｪｨｨ080609ｨ ｨｪｨｪ0401 0708ｨｨ ｨ 06050202 ｨｪｨｨ04ｨｺ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ 09 0908020102 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 (1 ｨｨ 3 %), ｨｮ090205ｨｨ ﾂｨｨ09ｨ 050609ｨｹ 090802ｨｬ07 ｨｮ01090602ｨｪｨｨ07 ｨｨ 09ｨｪｨｨ03ｨ 050609ｨｹ ﾂｨｨ090506 ｨｮ01090602ｨｪｨｨ07 070607ｨｮ050702ｨｨｨｨ 0106 1.6 ｪ1.8. 0602ｨｬ ｨｪ02 ｨｬ02ｨｪ0202 05ｨｰｨｨ 04ｨｪｨ ﾂ02ｨｪｨｨ07 04ｨ 6 09ｨｮｨｰ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 09 ｨｰ02 ﾂ02ｨｪｨｨ02 04ｨｨ09. 2. 03080605ｨｨ000208ｨ 02ｨｨ07 00000508, ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ0401 0708ｨｨ 08ｨ 0405ｨｨ ﾂｨｪ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ. ｨ ｪ 09080201ｨｪｨｨ02 04ｨｪｨ ﾂ02ｨｪｨｨ07 ﾂｨｨ0905ｨ ｨｮ01090602ｨｪｨｨ07 070607ｨｮ050702ｨｨｨｦ 00000508, ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ0401 0708ｨｨ 20, 5, 3 ｨｨ 1 % O 2 09 ｨｰ02 ﾂ02ｨｪｨｨ02 1 ｪ4-0006 07ｨ 0909ｨ 0302ｨｦ; ｨ ｪ ｨｺ08ｨｨ090402 07080605ｨｨ000208ｨ 02ｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 2-0006 07ｨ 0909ｨ 03ｨ 0708ｨｨ 090601020803ｨ ｨｪｨｨｨｨ O 2 (%): 20 (ｨｺ08ｨｨ09ｨ 07 1),5(ｨｺ08ｨｨ09ｨ 07 2),3(ｨｺ08ｨｨ09ｨ 07 3)ｨｨ1(ｨｺ08ｨｨ09ｨ 07 4). 050902040106 ﾂｨｺ06ｨｦ 0706ｨｺｨ 04ｨ ｨｪ04 010609ｨｰ06090208ｨｪ0402 06ｨｰ05ｨｨ ﾂｨｨ07 06ｨｰ 04ｨｪｨ ﾂ02ｨｪｨｨｨｦ 010507 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ060006 090601020803ｨ ｨｪｨｨ07 O 2 (20 %), P 1 7 0.05, n = 3. 4-0006 07ｨ 0909ｨ 03ｨ ｨ 06050202 ﾂ02ｨｬ 09 2 08ｨ 04ｨ 070802090403ｨ 05ｨｨ ﾂｨｨ090506 ｨｮ01090602ｨｪｨｨｨｦ 09 0905ｨｮ ﾂｨ 02 20%-ｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ 09 0908020102. 06ｨｺ090708020909ｨｨ07 0002ｨｪｨ ｨｰ020506ｨｬ0208ｨ 0404 09 ｨｮ09050609ｨｨ0701 08ｨ 0405ｨｨ ﾂｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ. 01ｨｨ 09 0601ｨｪ06ｨｬ ｨｨ04 ｨｨ0909050201ｨｮ02ｨｬ0401 06ｨ 08ｨ 04020609 00000508 ｨｪ02 06ｨ ｨｪｨ 08ｨｮ03ｨｨ05ｨｨ 090408ｨ 0302ｨｪｨｪ06ｨｦ 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪｨ htert, ｨｺ0601ｨｨ08ｨｮ06ｨｴ020006 ｨｺｨ ｨｰｨ 05ｨｨ- 06ｨ ｨ 05ｨｨ02ｨ 2 000802ｨｬ07 ｨｮ01090602ｨｪｨｨ07 ( ﾂ) 070607ｨｮ050702ｨｨｨｨ 00000508, ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ0401 0708ｨｨ 08ｨ 04ｨｪ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ, 09 ｨｰ02 ﾂ02ｨｪｨｨ02 1 ｪ4-0006 07ｨ 0909ｨ 0302ｨｦ 03ｨ 0909ｨ 03 050601020803ｨ ｨｪｨｨ02 ｨｺｨｨ090506080601ｨ, % 20 5 3 1 1-ｨｦ 73 1 7 6 79 1 7 9 641 7 3 671 7 4 2-ｨｦ 129 1 7 15 56 1 7 4 ｨ 55 1 7 4 ｨ 54 1 7 3 ｨ 3-ｨｦ 116 1 7 21 63 1 7 7 ｨ 88 1 7 9 ｨ 67 1 7 5 ｨ 4-ｨｦ 209 1 7 28 75 1 7 8 ｨ 104 1 7 15 ｨ 90 1 7 12 ｨ ｨ 020609ｨｰ06090208ｨｪ0602 06ｨｰ05ｨｨ ﾂｨｨ02 06ｨｰ 04ｨｪｨ ﾂ02ｨｪｨｨｨｦ 0708ｨｨ 20%-ｨｪ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ 02 2 ｨｪｨ 090606ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴ02ｨｬ 07ｨ 0909ｨ 0302, P 1 7 0.05(n=3).
13856 07. 00. 0404050609ｨ, 09. 09. 09ｨｮ08ｨ 09ｨｺ0609ｨ ｨｪｨｨ01 0002ｨｪ04 0902ｨｬ02ｨｦ09ｨｰ09ｨ Fos (FOSB ｨｨ FOSL1), ｨｺ0601ｨｨ08ｨｮ06ｨｴｨｨ02 ｨ 0205ｨｺｨｨ, ｨｺ06ｨｰ06080402, 01ｨｨｨｬ0208ｨｨ04ｨｮ0709ｨｹ 09 ｨ 0205ｨｺｨ ｨｬｨｨ 0902ｨｬ02ｨｦ09ｨｰ09ｨ Jun, ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｰ 09 000608ｨｬｨｨ080609ｨ ｨｪｨｨｨｨ ｨ 0205ｨｺｨ -ｨ ｨｺｨｰｨｨ09ｨ ｨｰ0608ｨ 1 (AP1); 0002ｨｪ04 PCNA ｨｨ CCND2, 07080601ｨｮｨｺｨｰ04 ｨｺ06ｨｰ06080401 0708020109ｨｰｨ 09050706ｨｰ 0906ｨ 06ｨｦ 02ｨｨｨｺ05ｨｨｨｪ04, ｨｪ0206ｨ 010601ｨｨｨｬ0402 010507 07020802010601ｨ ｨｺ0502ｨｰ06ｨｺ ｨｨ04 00ｨ 0404 G 1 09 S-00ｨ 04ｨｮ 09ｨｨｨｪｨｰ0204ｨ 020108, ｨ ｨｰｨ ｨｺ0302 0002ｨｪ CKS2, ｨｺ0601ｨｨ08ｨｮ06ｨｴｨｨｨｦ 080200ｨｮ0507ｨｰ0608ｨｪｨｮ06 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ02ｨｮ 02ｨｨｨｺ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ06ｨｦ ｨｺｨｨｨｪｨ 0404. 080806ｨｬ02 ｨｰ060006, 09 06ｨｰ0902ｨｰ ｨｪｨ 0706ｨｪｨｨ0302ｨｪｨｪ0602 090601020803ｨ ｨｪｨｨ02 ｨｺｨｨ090506080601ｨ ｨｮｨｬ02ｨｪｨｹ03ｨ 05ｨ 09ｨｹ 05ｨｺ090708020909ｨｨ07 CDKN2C ｪ 0002ｨｪｨ -ｨｨｨｪ00ｨｨｨ ｨｨｨｰ0608ｨ 02ｨｨｨｺ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ06ｨｦ ｨｺｨｨｨｪｨ 0404. 02ｨ 09ｨｮ030102ｨｪｨｨ02 04ｨｨ09. 3. 09ｨ 08ｨ ｨｺｨｰ0208ｨｨ09ｨｰｨｨｨｺｨ 08ｨ 0907080201020502ｨｪｨｨ07 00000508 0706 00ｨ 04ｨ ｨｬ ｨｺ0502ｨｰ06 ﾂｨｪ060006 02ｨｨｨｺ05ｨ 0708ｨｨ 08ｨ 0405ｨｨ ﾂｨｪ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ. ｨ ｪ 00ｨｨ09ｨｰ060008ｨ ｨｬｨｬｨ 08ｨ 0907080201020502ｨｪｨｨ07 ｨｺ0502ｨｰ06ｨｺ 0706 ｨｨｨｪｨｰ02ｨｪ09ｨｨ09ｨｪ0609ｨｰｨｨ 0005ｨｮ060802090202ｨｪ02ｨｨｨｨ (0608) ｨｨ0601ｨｨ01ｨ 07080607ｨｨ01ｨｨ07 (PI), 090606ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴ02ｨｦ 090601020803ｨ ｨｪｨｨ06 020108; ｨ ｪ ｨｺ0605ｨｨ ﾂ0209ｨｰ0902ｨｪｨｪ0602 090606ｨｰｨｪ060302ｨｪｨｨ02 PI + -ｨｺ0502ｨｰ06ｨｺ 09 070607ｨｮ050702ｨｨ0701 3-0006 07ｨ 0909ｨ 03ｨ 09 08ｨ 04ｨｪ0401 00ｨ 04ｨ 01 ｨｺ0502ｨｰ06 ﾂｨｪ060006 02ｨｨｨｺ05ｨ 0708ｨｨ 090601020803ｨ ｨｪｨｨｨｨ O 2 20,5ｨｨ1%(n=3). 00ｨｪ02010802ｨｪｨｨ02 ｨｺ0502ｨｰ06 ﾂｨｪ0401 ｨｰ0201ｨｪ06050600ｨｨｨｦ, 0609ｨｪ0609ｨ ｨｪｨｪ0401 ｨｪｨ ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨｨｨ ｨｮｨｪｨｨｨｺｨ 05ｨｹｨｪ0401 090906ｨｦ09ｨｰ09 00000508, 09 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｮ06 0708ｨ ｨｺｨｰｨｨｨｺｨｮ 0709050702ｨｰ0907 ｨ ｨｺｨｰｨｮｨ 05ｨｹｨｪ06ｨｦ 04ｨ 01ｨ ﾂ02ｨｦ 0906090802ｨｬ02ｨｪｨｪ06ｨｦ ｨｬ0201ｨｨ02ｨｨｨｪ04 ｨｨ ｨｰ0802ｨ ｨｮ02ｨｰ 09060902080302ｨｪ09ｨｰ090609ｨ ｨｪｨｨ07 ｨｬ02ｨｰ06010609 0706010006ｨｰ0609ｨｺｨｨ ｨｺ0502ｨｰ06 ﾂｨｪ0401 07080207ｨ 08ｨ ｨｰ0609. 00 ｨｪｨ 09ｨｰ0607ｨｴ0202 090802ｨｬ07 010608060306 ｨｨ04090209ｨｰｨｪ04 ｨｬｨｪ0600ｨｨ02 ｨｬ0608000600ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0402 060906ｨ 02ｨｪｨｪ0609ｨｰｨｨ 00000508 in vitro (Caplan, 1991; Gimble et al., 2007). 0201ｨｪｨ ｨｺ06 09ｨｮｨｴ0209ｨｰ09ｨｮ02ｨｰ ｨｪ02010609ｨｰｨ ｨｰ06 ﾂｨｪ06 05ｨｺ09070208ｨｨｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ0401 01ｨ ｨｪｨｪ0401 06ｨｰｨｪ0609ｨｨｨｰ0205ｨｹｨｪ06 0905ｨｨ07ｨｪｨｨ07 0209ｨｰ0209ｨｰ0902ｨｪｨｪ060006 ｨｬｨｨｨｺ080606ｨｺ08ｨｮ0302ｨｪｨｨ07, ｨｺ06ｨｰ06080602 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ06 06ｨｰ05ｨｨ ﾂｨ 02ｨｰ0907 06ｨｰ ｨｮ09050609ｨｨｨｦ, 09060401ｨ 09ｨ 02ｨｬ0401 in vitro. 0201ｨｪｨｨｨｬ ｨｨ04 ｨｪｨ ｨｨｨ 06050202 09ｨ 03ｨｪ0401 00ｨ ｨｺｨｰ06080609 0709050702ｨｰ0907 00ｨ 04060904ｨｦ 090609ｨｰｨ 09 0908020104, 07ｨ 08ｨ ｨｬ02ｨｰ0804 ｨｺ06ｨｰ060806ｨｦ ｨｰ08ｨ 01ｨｨ02ｨｨ06ｨｪｨｪ06 0609ｨｰｨ 06ｨｰ0907 ｨｪｨ ｨｨｨ 06050202 ｨｺ06ｨｪ09020809ｨ ｨｰｨｨ09ｨｪ04ｨｬ 0708ｨｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ. 0308ｨｨ 05ｨｰ06ｨｬ ｨｮ08060902ｨｪｨｹ 0502 2 0708ｨｨｨ 05ｨｨ03ｨ 02ｨｰ0907 ｨｺ ｨｰｨｺｨ ｨｪ020906ｨｬｨｮ (5 %), ｨｰ060001ｨ ｨｺｨ ｨｺ 090601020803ｨ ｨｪｨｨ02 ｨｺｨｨ090506080601ｨ 09 06ｨ 04 ﾂｨｪ0401 0502 2 -ｨｨｨｪｨｺｨｮｨ ｨ ｨｰ0608ｨ 01 090606ｨｰ0902ｨｰ09ｨｰ09ｨｮ02ｨｰ 020006 090601020803ｨ ｨｪｨｨ06 09 09060401ｨｮ0102 (06ｨｺ060506 20 %), ﾂｨｰ06 070802090403ｨ 02ｨｰ 020006 ｨｮ08060902ｨｪｨｹ 09 ｨｰｨｺｨ ｨｪ020906ｨｬ ｨｬｨｨｨｺ080606ｨｺ08ｨｮ0302ｨｪｨｨｨｨ ｨｨ ｨｬ060302ｨｰ 09ｨｰｨ ｨｰｨｹ 0708ｨｨ ﾂｨｨｨｪ06ｨｦ 090604ｨｬ0603ｨｪ0401 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ 090906ｨｦ09ｨｰ09 00000508. 00 09090704ｨｨ 09 05ｨｰｨｨｨｬ 090409ｨｺｨ 040409ｨ 06ｨｰ0907 07080201070605060302ｨｪｨｨ07 06 ｨｰ06ｨｬ, ﾂｨｰ06 00ｨｨ04ｨｨ06050600ｨｨ ﾂ0209ｨｺ0602 090601020803ｨ ｨｪｨｨ02 ｨｺｨｨ090506080601ｨ (3 ｪ7 %) 0709050702ｨｰ0907 0607ｨｰｨｨｨｬｨ 05ｨｹｨｪ04ｨｬ 010507 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 0708060002ｨｪｨｨｨｰ0608ｨｪ0401 ｨｺ0502ｨｰ06ｨｺ (Fehrer et. al., 2007; 09ｨｮ08ｨ 09ｨｺ0609ｨ ｨｨ 0108., 2009), ｨ ｨ 06050202 ｨｪｨｨ04ｨｺｨｨｨｦ ｨｮ08060902ｨｪｨｹ ｨｬ060302ｨｰ 06ｨｺｨ 04ｨ ｨｰｨｹ 00ｨｨ0706ｨｺ09ｨｨ ﾂ0209ｨｺｨｨｨｦ 05000002ｨｺｨｰ. 05050201ｨｮ02ｨｰ 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ ｨｰｨ ｨｺ0302, ﾂｨｰ06 00000508 09 09090704ｨｨ 09 0904070605ｨｪ02ｨｪｨｨ02ｨｬ 08020002ｨｪ0208ｨ ｨｰｨｨ09ｨｪ0401 00ｨｮｨｪｨｺ02ｨｨｨｦ ｨｪ02080201ｨｺ06 06ｨｺｨ 040409ｨ 06ｨｰ0907 09 ｨｮ09050609ｨｨ0701 ｨｺ08ｨ ｨｦｨｪ02 ｨｪｨｨ04ｨｺ060006 0906010208- ｨｰｨｨ ﾂ0209ｨｺｨｮ06 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ02ｨｮ 000208ｨｬ02ｨｪｨｰｨ ｨｰ020506ｨｬ0208ｨ 0404, 09 ｨｮ09050609ｨｨ0701 ｨｺｨ ｨｺ 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ060006 (20 % 02 2 ), ｨｰｨ ｨｺ ｨｨ 0706ｨｪｨｨ0302ｨｪｨｪ060006 (5 % 02 2 ) ｨｮ080609ｨｪ07 (ｨ 05ｨｨ04ｨｺ060006 ｨｺ 00ｨｨ04ｨｨ06050600ｨｨ ﾂ0209ｨｺ06ｨｬｨｮ) 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ. 0602ｨｬ ｨｪ02 ｨｬ02ｨｪ0202 ｨｪ02ｨ 0605ｨｹ030602 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 07080601ｨｮｨｺｨｰｨ 0102ｨｰ02ｨｺｨｰｨｨ080609ｨ 05ｨｨ 09 0601ｨｪ06ｨｬ ｨｨ04 06ｨ 08ｨ 04020609 ｨｺ0502ｨｰ06ｨｺ, ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ0401 0708ｨｨ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ 20 % (08ｨｨ09. 4, ｨ, 0106080603ｨｺｨ 3), ｨｨ 09 0109ｨｮ01 06ｨ 08ｨ 0402ｨ 01 ｨｺ0502ｨｰ06ｨｺ, ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ0401 0708ｨｨ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ 5 % (08ｨｨ09. 4, ｨ, 0106080603ｨｺｨｨ 1 ｨｨ 3), ﾂｨｰ06 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ02ｨｰ 06 ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｬ ｨｮ080609ｨｪ02 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 05ｨｰ060006 000208ｨｬ02ｨｪｨｰｨ 09 00000508 ｨｪｨ 01ｨ ｨｪｨｪ06ｨｬ 05ｨｰｨ 0702 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07. 0708060902ｨｪｨｹ 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪ0609, 06070609080201ｨｮ06ｨｴｨｨ01 07080605ｨｨ000208ｨ 02ｨｨ06. 0508ｨ 09ｨｪｨｨｨｰ0205ｨｹｨｪ04ｨｦ ｨ ｨｪｨ 05ｨｨ04 080204ｨｮ05ｨｹｨｰｨ ｨｰ0609, 070605ｨｮ ﾂ02ｨｪｨｪ0401 0708ｨｨ 070605ｨｪ060002ｨｪ06ｨｬｨｪ06ｨｬ ｨｨ09090502010609ｨ ｨｪｨｨｨｨ 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪ0609 00000508 03ｨｨ08060906ｨｦ ｨｰｨｺｨ ｨｪｨｨ, 0706ｨｺｨ 04ｨ 05, ﾂｨｰ06 09 ｨｮ09050609ｨｨ0701 0706ｨｪｨｨ0302ｨｪｨｪ060006 0106 5 % 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ 070806ｨｨ09010601ｨｨ0506 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 ｨｮ080609ｨｪ07 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪ0609, 06ｨｰ0902- ﾂｨ 06ｨｴｨｨ01 04ｨ 0909ｨｰｨｮ070502ｨｪｨｨ02 ｨｺ0502ｨｰ06ｨｺ 09 ｨｺ0502ｨｰ06 ﾂｨｪ04ｨｦ 02ｨｨｨｺ05 ｨｨ 070604ｨｨｨｰｨｨ09ｨｪ06 080200ｨｮ05ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｨ01 07080605ｨｨ000208ｨ 02ｨｨ06 (ｨｰｨ ｨ 05. 3). 05080201ｨｨ 04ｨｨ09. 4. 08ｨｪｨ 05ｨｨ04 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪｨ, ｨｺ0601ｨｨ08ｨｮ06ｨｴ020006 ｨｪ02090705ｨ ｨｦ09ｨｨ080609ｨ ｨｪｨｪｨｮ06 ｨｨ0406000608ｨｬｨｮ ｨｺｨ ｨｰｨ 05ｨｨｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ0204 ｨｰ020506ｨｬ0208ｨ 0404 (htert) 09 ｨｰ02 ﾂ02ｨｪｨｨ02 50 02ｨｨｨｺ050609 030004. 03080601ｨｮｨｺｨｰ ｨ ｨｬ0705ｨｨ00ｨｨｨｺｨ 02ｨｨｨｨ (1 7300 07. ｨｪ.) 09ｨｨ0102ｨｪ 09 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ0401 06ｨ 08ｨ 0402ｨ 01 05ｨｨｨｪｨｨｨｦ 0607ｨｮ01060502090401 ｨｺ0502ｨｰ06ｨｺ HeLa, SiHa 09 06ｨ 08ｨ 0402ｨ 01 00000508 40-0006 07ｨ 0909ｨ 03ｨ, ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ0401 0708ｨｨ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ 20 (ｨ ) ｨｨ5(ｨ ) %.
13030609ｨｰ0607ｨｪｨｪ0602 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ02 00000508 0708ｨｨ 0706ｨｪｨｨ0302ｨｪｨｪ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ 857 0604ｨｬ02ｨｪ02ｨｪｨｨ02 ｨｮ080609ｨｪ07 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪ0609, ｨ 09090602ｨｨｨｨ080609ｨ ｨｪｨｪ0401 09 07080605ｨｨ000208ｨ 02ｨｨ02ｨｦ 00000508, 0708ｨｨ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨｨｨ 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ 06ｨｰ 20 0106 5 % 06ｨ ｨ 05ｨｨ02ｨ 3 05090405ｨｺｨ ｨｪｨ 0706090502010609ｨ ｨｰ0205ｨｹｨｪ0609ｨｰｨｹ 09 ｨ ｨ 04ｨ 01 01ｨ ｨｪｨｪ0401 (RefSeq) 05ｨｨｨｬ090605 0002ｨｪｨ 01ｨ 0409ｨ ｨｪｨｨ02 07080601ｨｮｨｺｨｰｨ 06ｨｪｨｰ02ｨｪ09ｨｨ09ｨｪ0609ｨｰｨｹ 09ｨｨ00ｨｪｨ 05ｨ ｨｪｨ ｨｬｨｨｨｺ0806 ﾂｨｨ0702, 06ｨｰｨｪ. 0201. 20 % 02 2 5%02 2 050606ｨｰｨｪ060302ｨｪｨｨ02 09ｨｨ00ｨｪｨ 050609 NM_006732.1 FOSB 090205ｨｺｨｨ 0902ｨｬ02ｨｦ09ｨｰ09ｨ fos, ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｰ 09 000608ｨｬｨｨ080609ｨ ｨｪｨｨｨｨ 356.8 84.2 4.2 ｨ NM_005438.2 FOSL1 ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪ060006 00ｨ ｨｺｨｰ0608ｨ AP-1 301.3 93.3 3.2 ｨ NM_182649.1 PCNA 08010208ｨｪ04ｨｦ ｨ ｨｪｨｰｨｨ0002ｨｪ 07080605ｨｨ000208ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｺ0502ｨｰ06ｨｺ 182.6 85.2 2.1 ｨ NM_001759.2 CCND2 G 1 /S-09070202ｨｨ00ｨｨ ﾂｨｪ04ｨｦ 02ｨｨｨｺ05ｨｨｨｪ D2 315.3 156.1 2.0 ｨ NM_001827.1 CKS2 040200ｨｮ0507ｨｰ0608ｨｪｨ 07 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ02ｨ 02ｨｨｨｺ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ06ｨｦ ｨｺｨｨｨｪｨ 0404 287.6 143.2 2.0 ｨ NM_078626.2 CDKN2C 06ｨｪ00ｨｨｨ ｨｨｨｰ0608 02ｨｨｨｺ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ06ｨｦ ｨｺｨｨｨｪｨ 0404 50.6 136.2 0.4 ｨ ｨ 020609ｨｰ06090208ｨｪ0602 06ｨｰ05ｨｨ ﾂｨｨ02 06ｨｰ 04ｨｪｨ ﾂ02ｨｪｨｨｨｦ 0708ｨｨ 20%-ｨｪ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ 02 2, P 1 7 0.05. 03ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ, ｨｺ06ｨｰ06080602 ｨｨｨｬ0202ｨｰ ｨｬ0209ｨｰ06 0708ｨｨ 07ｨ ｨｰ06050600ｨｨ ﾂ0209ｨｺｨｨ01 07080602020909ｨ 01 ｨｨ05ｨｨ 0706090802030102ｨｪｨｨｨｨ ｨｰｨｺｨ ｨｪ02ｨｦ. 00 09090704ｨｨ 09 05ｨｰｨｨｨｬ 070802010708ｨｨｨｪｨｨｨｬｨ 06ｨｰ0907 07060704ｨｰｨｺｨｨ ｨｨ04ｨｮ ﾂ02ｨｪｨｨ07 090609ｨｰ0607ｨｪｨｨ07 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ0401 ｨｺ0502ｨｰ06ｨｺ 0708ｨｨ 08ｨ 0405ｨｨ ﾂｨｪ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ (09ｨｮ08ｨ 09ｨｺ0609ｨ, 08ｨｪ0601ｨｨｨｪｨ, 2007; Fehrer et al., 2007; 09ｨｮ08ｨ 09ｨｺ0609ｨ ｨｨ 0108., 2009; Dos Santos et al., 2010; Lavrentieva et al., 2010; Basciano et al., 2011). 010206ｨ 010601ｨｨｨｬ04ｨｬ 07ｨ 08ｨ ｨｬ02ｨｰ0806ｨｬ 09 ｨｨ0102ｨｪｨｰｨｨ00ｨｨｨｺｨ 02ｨｨｨｨ 090401020502ｨｪｨｪ0401 ｨｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ0401 ｨｺ0502ｨｰ06ｨｺ 0709050702ｨｰ0907 0607080201020502ｨｪｨｨ02 ｨｨ 070601ｨｰ090208030102ｨｪｨｨ02 09ｨｰｨ ｨｰｨｮ09ｨ ｨｬ020402ｨｪ01ｨｨｨｬｨｪ0401 09ｨｰ0806ｨｬｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ. 08 090603ｨ 0502ｨｪｨｨ06, 09 ｨｪｨ 09ｨｰ0607ｨｴ0202 090802ｨｬ07 ｨｪ02 0708020109ｨｰｨ 09050702ｨｰ0907 090604ｨｬ0603ｨｪ04ｨｬ 090401020502ｨｪｨｨ02 0601ｨｪ060006 ｨｨ05ｨｨ ｨｪ0209ｨｺ0605ｨｹｨｺｨｨ01 0607080201020502ｨｪｨｪ0401 070609020801ｨｪ0609ｨｰｨｪ0401 ｨｬｨ 08ｨｺ02080609, ｨｺ06ｨｰ06080402 070604090605ｨｨ05ｨｨ ｨ 04 ｨｨ0102ｨｪｨｰｨｨ00ｨｨ02ｨｨ080609ｨ ｨｰｨｹ 00000508. 04ｨ 0405ｨｨ ﾂｨｪ0402 05ｨｨｨｰ0208ｨ ｨｰｨｮ08ｨｪ0402 ｨｨ09ｨｰ06 ﾂｨｪｨｨｨｺｨｨ 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ06ｨｰ 06 010609ｨｰｨ ｨｰ06 ﾂｨｪ06 ｨ 0605ｨｹ0306ｨｬ ｨｺ0605ｨｨ ﾂ0209ｨｰ0902 ｨ ｨｪｨｰｨｨ0002ｨｪ0609, ｨｺ06ｨｰ06080402 ｨｬ0600ｨｮｨｰ ｨ 04ｨｰｨｹ 09 08ｨ 04ｨｪ06ｨｦ 09ｨｰ020702ｨｪｨｨ 05ｨｺ090708020909ｨｨ080609ｨ ｨｪ04 ｨｪｨ 070609020801ｨｪ0609ｨｰｨｨ 00000508 08ｨ 0405ｨｨ ﾂｨｪ060006 070806ｨｨ090106030102ｨｪｨｨ07, 09 ｨｰ06ｨｬ ﾂｨｨ090502 ｨｨ 03ｨｨ08060906ｨｦ ｨｰｨｺｨ ｨｪｨｨ (Gronthos et al., 2001; Gimble et al., 2007; 05ｨ ｨｬ06ｨｦ050609ｨｨ ﾂ ｨｨ 0108., 2013). 00 ｨｪｨ 0302ｨｬ ｨｨ09090502010609ｨ ｨｪｨｨｨｨ 09 ｨｮ09050609ｨｨ0701 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ 00000508 09ｨｰｨ ｨ ｨｨ05ｨｹｨｪ06 05ｨｺ090708020909ｨｨ080609ｨ 05ｨｨ ｨｰｨ ｨｺｨｨ02 070609020801ｨｪ0609ｨｰｨｪ0402 ｨｬｨ 08ｨｺ020804, ｨｺｨ ｨｺ CD105 (05ｨｪ01060005ｨｨｨｪ), CD90 (0802020207ｨｰ0608ｨｪｨ 07 ｨｰｨｨ080604ｨｨｨｪｨｺｨｨｨｪｨ 04ｨ -1) ｨｨ CD73 (5R-ｨｪｨｮｨｺ050206ｨｰｨｨ01ｨ 04ｨ ), 000608ｨｬｨｨ08ｨｮ07 ｨｰ02ｨｬ 09ｨ ｨｬ04ｨｬ 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ04ｨｦ ｨｨｨｬｨｬｨｮｨｪ060002ｨｪ06ｨｰｨｨ07ｨｨ ﾂ0209ｨｺｨｨｨｦ 07080600ｨｨ05ｨｹ. 05ｨｪｨｨ0302ｨｪｨｨ02 010605ｨｨ CD73 + -ｨｺ0502ｨｰ06ｨｺ 0708ｨｨ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨｨｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ090506080601ｨ ｨ 040506 ｨｰ08ｨ ｨｪ04ｨｨｨｰ0608ｨｪ04ｨｬ, ｨｨ 09 01ｨ 05ｨｹｨｪ02ｨｦ0302ｨｬ ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 05ｨｰｨｨ01 ｨｺ0502ｨｰ06ｨｺ 09060909ｨｰｨ ｨｪｨ 0905ｨｨ09ｨ 050609ｨｹ 0106 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ060006 ｨｮ080609ｨｪ07. 0604090209ｨｰｨｪ06, ﾂｨｰ06 CD73 0708020109ｨｰｨ 09050702ｨｰ 0906ｨ 06ｨｦ ｨｬ02ｨｬｨ 08ｨ ｨｪｨｪ06-09090704ｨ ｨｪｨｪ04ｨｦ 000208ｨｬ02ｨｪｨｰ, ｨｺ06ｨｰ060804ｨｦ 0708ｨｨｨｪｨｨｨｬｨ 02ｨｰ ｨ ｨｺｨｰｨｨ09ｨｪ0602 ｨｮ ﾂｨ 09ｨｰｨｨ02 09 ｨｺｨ ｨｰｨ ｨ 0605ｨｨ04ｨｬ02 07ｨｮ08ｨｨｨｪ0609 ｨｨ 07ｨｨ08ｨｨｨｬｨｨ01ｨｨｨｪ0609, ｨｺｨ ｨｰｨ 05ｨｨ04ｨｨ08ｨｮ02ｨｰ 0708020908ｨ ｨｴ02ｨｪｨｨ02 080008 0106 ｨ 0102ｨｪ0604ｨｨｨｪｨ ｨｨ 04ｨ 09ｨｨ09ｨｨｨｰ 06ｨｰ ｨｮ080609ｨｪ07 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ (Ledoux et al., 2003). 0308ｨｨ ｨｨ09090502010609ｨ ｨｪｨｨｨｨ 08ｨ ｨ 06ｨｰ04 05ｨｰ060006 000208ｨｬ02ｨｪｨｰｨ 09 ｨｮ09050609ｨｨ0701 0706ｨｪｨｨ0302ｨｪｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ ｨ 040506 0706ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ02 020006 ｨｮ080609ｨｪ07 ｨｪｨ 070609020801ｨｪ0609ｨｰｨｨ 09 ｨｮ09050609ｨｨ0701 00ｨｨ0706ｨｺ09ｨｨｨｨ ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ 060706090802010609ｨ ｨｪ06 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ02ｨｦ 08ｨ 0405ｨｨ ﾂｨｪ0401 ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪ0401 00ｨ ｨｺｨｰ06080609, 09 ｨｰ06ｨｬ ﾂｨｨ090502 HIF-1 (Synnestvedt et al., 2002). 01ｨ ｨ 050601ｨ 02ｨｬ0602 09 ｨｪｨ 0302ｨｦ 08ｨ ｨ 06ｨｰ02 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ02 ｨｬ06080006050600ｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ 09 ｨｮ09050609ｨｨ0701 00ｨｨ0706ｨｺ09ｨｨｨｨ ｨ 040506 06ｨｰｨｬ02 ﾂ02ｨｪ06 ｨｨ 09 06ｨｰｨｪ060302ｨｪｨｨｨｨ 00000508 ｨｺ0609ｨｰｨｪ060006 ｨｬ060400ｨ ﾂ0205060902ｨｺｨ : 48- ﾂｨ 0906090602 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ02 ｨｺ0502ｨｰ06ｨｺ 09 ｨｮ09050609ｨｨ0701 1%-ｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ 0708ｨｨ090601ｨｨ0506 ｨｺ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ06 ｨｨ01 08ｨ 04ｨｬ02080609, ｨｺ0806ｨｬ02 ｨｰ060006, ｨｺ0502ｨｰｨｺｨｨ 0708ｨｨ06ｨ 0802ｨｰｨ 05ｨｨ ｨ 06050202 0904ｨｰ07ｨｪｨｮｨｰｨｮ06 000608ｨｬｨｮ (Raheja et al., 2011). 01ｨ ｨｺ06070502ｨｪｨｨ02 09 ｨｺｨｮ05ｨｹｨｰｨｮ08ｨ 01 00000508 09 0708060202090902 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 09ｨｨ05ｨｹｨｪ06 08ｨ 090705ｨ 09ｨｰｨ ｨｪｨｪ0401 ｨｪ0207080605ｨｨ000208ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｺ0502ｨｰ06ｨｺ ｨ 0605ｨｹ03060006 08ｨ 04ｨｬ0208ｨ ｨｨ09090502010609ｨ ｨｰ0205ｨｨ 090907040409ｨ 06ｨｰ 0906 09ｨｰｨ 0802ｨｪｨｨ02ｨｬ 070607ｨｮ050702ｨｨｨｨ, 06 ﾂ02ｨｬ 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ02ｨｰ ｨ ｨｺｨｰｨｨ09ｨｪｨ 07 05ｨｺ090708020909ｨｨ07 b-00ｨ 05ｨ ｨｺｨｰ0604ｨｨ01ｨ 0404 09 05ｨｰｨｨ01 ｨｺ0502ｨｰｨｺｨ 01 (Safwani et al., 2012). 05ｨｪｨｨ0302ｨｪｨｨ02 010605ｨｨ ｨｺ08ｨｮ07ｨｪ0401 08ｨ 090705ｨ 09ｨｰｨ ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 09 ｨｮ09050609ｨｨ0701 0706ｨｪｨｨ0302ｨｪｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ 0706040906050702ｨｰ 070802010706050603ｨｨｨｰｨｹ, ﾂｨｰ06 06ｨｰｨｪ0609ｨｨｨｰ0205ｨｹｨｪｨ 07 00ｨｨ07020806ｨｺ09ｨｨ07 ｨｬ060302ｨｰ 07090507ｨｰｨｹ0907 00ｨ ｨｺｨｰ060806ｨｬ, 070806090602ｨｨ08ｨｮ06ｨｴｨｨｨｬ 070607090502ｨｪｨｨ02 ｨｰｨ ｨｺｨｨ01 ｨｺ0502ｨｰ06ｨｺ 09 ｨｺｨｮ05ｨｹｨｰｨｮ08ｨ 01 00000508. 020607ｨｮ09ｨｺｨ 07, ﾂｨｰ06 05ｨｰ06 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ02ｨｰ 06ｨ ｨｨ01 0706090802030102ｨｪｨｨｨｨ 09 0708060202090902 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07, ｨｬ0603ｨｪ06 070802010706050603ｨｨｨｰｨｹ, ﾂｨｰ06 0708ｨｨｨ 05ｨｨ0302ｨｪｨｨ02 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ090506080601ｨ 09 0908020102 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 ｨｺ ｨｰｨｺｨ ｨｪ020906ｨｬｨｮ ｨｮ080609ｨｪ06 06ｨ 02090702 ﾂｨｨ09ｨ 02ｨｰ 09ｨｪｨｨ0302ｨｪｨｨ02 09ｨｰ020702ｨｪｨｨ 06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪ060006 09ｨｰ08020909ｨ ｨｨ 0002ｨｰ0208060002ｨｪｨｪ0609ｨｰｨｨ ｨｺｨｮ05ｨｹｨｰｨｮ08 00000508. 0201ｨｪｨ ｨｺ06 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ02 0708ｨｨ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ 1 %, 0902080607ｨｰｨｪ06 06ｨｺｨ 040409ｨ 07 07060908020301ｨ 06ｨｴ0202 0906040102ｨｦ09ｨｰ09ｨｨ02, 09ｨｪ0609ｨｹ 0708ｨｨ090601ｨｨｨｰ ｨｺ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ06 0002ｨｰ0208060002ｨｪｨｪ0609ｨｰｨｨ ｨｺｨｮ05ｨｹｨｰｨｮ0804, ﾂｨｰ06 0708060709050702ｨｰ0907 09 070607090502ｨｪｨｨｨｨ 09ｨｨ05ｨｹｨｪ06 08ｨ 090705ｨ 09ｨｰｨ ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ｨｺ 4-ｨｬｨｮ 07ｨ 0909ｨ 03ｨｮ. 0308020109ｨｰｨ 090502ｨｪｨｪ0402 01ｨ ｨｪｨｪ0402 06 0905ｨｨ07ｨｪｨｨｨｨ 0706ｨｪｨｨ0302ｨｪｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ ｨｪｨ 07080605ｨｨ000208ｨ ｨｰｨｨ09ｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 00000508 03ｨｨ08060906ｨｦ ｨｰｨｺｨ ｨｪｨｨ 09060005ｨ 09ｨｮ06ｨｰ0907 09 08070106ｨｬ ｨｨ09090502010609ｨ ｨｪｨｨｨｦ, 0102ｨｬ06ｨｪ09ｨｰ08ｨｨ08ｨｮ06ｨｴｨｨ01 090604ｨｬ0603ｨｪ0609ｨｰｨｹ 09ｨｰｨｨｨｬｨｮ050702ｨｨｨｨ 07080605ｨｨ000208ｨ 02ｨｨｨｨ ｨｪ0201ｨｨ0000020802ｨｪ02ｨｨ080609ｨ ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ｨｨ04 08ｨ 0405ｨｨ ﾂｨｪ0401 ｨｨ09ｨｰ06 ﾂｨｪｨｨｨｺ0609 0708ｨｨ 09ｨｪｨｨ0302ｨｪｨｨｨｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ02ｨｦ ｨｺｨｨ090506080601ｨ. 06ｨ ｨｺ, 0706ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 12-09ｨｮｨｰ06 ﾂｨｪ0602 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ02 00000508 ｨｺ0609ｨｰｨｪ060006 ｨｬ060400ｨ ﾂ0205060902ｨｺｨ ｨｪｨ 08ｨ ｨｪｨｪｨｨ01 07ｨ 0909ｨ 03ｨ 01 0708ｨｨ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ 2 % 090607080609060301ｨ 050609ｨｹ ｨ 0605ｨｹ03ｨｨｨｬ 0708ｨｨ080609ｨｰ06ｨｬ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 070607ｨｮ050702ｨｨｨｨ, 0708ｨｨ 05ｨｰ06ｨｬ ｨｰｨ ｨｺ0302 06ｨｰｨｬ02 ﾂｨ 05ｨｨ 0906ｨｺ08ｨ ｨｴ02ｨｪｨｨ02 05ｨ 00-00ｨ 0404 0706 0908ｨ 09ｨｪ02ｨｪｨｨ06 09 ｨｰｨ ｨｺ060906ｨｦ 0708ｨｨ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ 20 % (Dos Santos et al., 2010). 03060106ｨ ｨｪ0402 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 ｨｪｨ ｨ 050601ｨ 05ｨｨ ｨｨ 0708ｨｨ 0105ｨｨｨｰ0205ｨｹｨｪ06ｨｬ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨｨｨ 09 ｨｮ09050609ｨｨ0701 3%-ｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ (Fehrer et al., 2007). 00060408ｨ 09ｨｰｨ 06ｨｴｨｨｨｦ 07080605ｨｨ000208ｨ ｨｰｨｨ09ｨｪ04ｨｦ 0706ｨｰ02ｨｪ02ｨｨｨ 05 06ｨｰｨｬ02 ﾂ02ｨｪ 010507 00000508 07ｨｮ070609ｨｨｨｪ04 09 ｨｮ09050609ｨｨ0701 08ｨ 0405ｨｨ ﾂｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ. 070302 ﾂ02080204 72 ﾂ 09 ｨｮ09050609ｨｨ0701 5 ｨｨ 2.5 % 02 2 07080605ｨｨ000208ｨ 02ｨｨ07 ｨｮ090205ｨｨ ﾂｨｨ09ｨ 05ｨ 09ｨｹ, 0601ｨｪｨ ｨｺ06 0708ｨｨ 1.5%-ｨｪ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ 02 2, ｨｪｨ 06ｨ 060806ｨｰ, ｨｪ0209ｨｺ0605ｨｹｨｺ06 09ｨｪｨｨ03ｨ 05ｨ 09ｨｹ (Lavrentieva et al., 2010). 0508ｨ 09ｨｪｨｨｨｰ0205ｨｹｨｪ04ｨｦ ｨ ｨｪｨ 05ｨｨ04 07080605ｨｨ000208ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 00000508, 090401020502ｨｪｨｪ0401 ｨｨ04 07ｨｮ05ｨｹ0704 04ｨｮｨ ｨ, 0708ｨｨ 08ｨ 0405ｨｨ ﾂｨｪ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ (1, 3, 10 ｨｨ 20 %) 0706ｨｺｨ 04ｨ 05, ﾂｨｰ06 ｨｪｨ ｨｪｨ ﾂｨ 05ｨｹｨｪ0401 05ｨｰｨ 07ｨ 01 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 (4 09ｨｮｨｰ) ｨｪｨ ｨｨｨ 0605ｨｹ0302ｨｦ 09ｨｺ06080609ｨｰｨｹ06 07080605ｨｨ000208ｨ 02ｨｨｨｨ 06ｨ 05ｨ 01ｨ 05ｨｨ ｨｺ0502ｨｰｨｺｨｨ 09 ｨｮ09050609ｨｨ0701 3%-ｨｪ060006 090601020803ｨ ｨｪｨｨ07 02 2, ｨｰ060001ｨ ｨｺｨ ｨｺ 09 0108ｨｮ00ｨｨ01 0905ｨｮ- ﾂｨ 0701 09ｨｺ06080609ｨｰｨｹ 07080605ｨｨ000208ｨ 02ｨｨｨｨ ｨ 0405ｨ 0906ｨｨ04ｨｬ0208ｨｨｨｬ06ｨｦ. 0906050202 0105ｨｨｨｰ0205ｨｹｨｪ0602 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ02 0708ｨｨ090601ｨｨ0506 ｨｺ 090408ｨ 09ｨｪｨｨ09ｨ ｨｪｨｨ06
13858 07. 00. 0404050609ｨ, 09. 09. 09ｨｮ08ｨ 09ｨｺ0609ｨ 05ｨｰ060006 0706ｨｺｨ 04ｨ ｨｰ020507 0708ｨｨ 09090201 ｨｨ0909050201ｨｮ02ｨｬ0401 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ0701 ｨｺｨｨ090506080601ｨ (Iida et al., 2010). 0604090209ｨｰｨｪ06, ﾂｨｰ06 09 ｨｺ06ｨｪｨｰ08060502 04ｨ 07080605ｨｨ000208ｨ 02ｨｨ02ｨｦ ｨｺ0502ｨｰｨｺｨｨ 09ｨ 03ｨｪｨｮ06 080605ｨｹ ｨｨ0008ｨ 02ｨｰ ｨｰ020506ｨｬ0208ｨ 04ｨ ｪ 000208ｨｬ02ｨｪｨｰ, 010609ｨｰ08ｨ ｨｨ09ｨ 06ｨｴｨｨｨｦ ｨｰ020506ｨｬ0208ｨｪ0402 070609ｨｰ060804 020108. 00 ｨｺ0502ｨｰｨｺｨ 01 08ｨ 0405ｨｨ ﾂｨｪ0401 ｨｰｨｨ070609 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 ｨｰ020506ｨｬ0208ｨ 0404 09ｨｰ08060006 080200ｨｮ05ｨｨ08ｨｮ02ｨｰ0907. 040701 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ 0706ｨｺｨ 04ｨ 05, ﾂｨｰ06 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 ｨｰ020506ｨｬ0208ｨ 0404 09090704ｨ ｨｪｨ 09 ｨｰ08ｨ ｨｪ09000608ｨｬｨ 02ｨｨ02ｨｦ ｨｺ0502ｨｰ06ｨｺ, 0708ｨｨ06ｨ 0802ｨｰｨ 06ｨｴｨｨ01 0706ｨｰ02ｨｪ02ｨｨｨ 05 ｨｺ ｨｪ02060008ｨ ｨｪｨｨ ﾂ02ｨｪｨｪ06ｨｬｨｮ 01020502ｨｪｨｨ06. 0201ｨｪｨ ｨｺ06 ｨｪｨ 05ｨｨ ﾂｨｨ02 ｨ ｨｺｨｰｨｨ09ｨｪ06ｨｦ ｨｰ020506ｨｬ0208ｨ 0404 0706ｨｺｨ 04ｨ ｨｪ06 ｨｨ 09 09ｨｰ09060506090401 ｨｺ0502ｨｰｨｺｨ 01 060800ｨ ｨｪｨｨ04ｨｬｨ (050902080209ｨ ｨｨ 0108., 2010). 030605ｨｮ ﾂ02ｨｪｨｪ0402 ｨｪｨ ｨｬｨｨ 01ｨ ｨｪｨｪ0402 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ06ｨｰ 06 ｨｰ06ｨｬ, ﾂｨｰ06 ｨｬ020402ｨｪ01ｨｨｨｬｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ 09ｨｰ0806ｨｬ04 090408060905060006 060800ｨ ｨｪｨｨ04ｨｬｨ 06ｨ 05ｨ 01ｨ 06ｨｰ ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ04ｨｬ ｨｮ080609ｨｪ02ｨｬ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 05ｨｰ060006 000208ｨｬ02ｨｪｨｰｨ, ｨｺ06ｨｰ0608ｨ 07 ｨｪ02 09060408ｨ 09ｨｰｨ 02ｨｰ 0708ｨｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨｨｨ 09 ｨｮ09050609ｨｨ0701 0706ｨｪｨｨ0302ｨｪｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ, ｨｪ0209ｨｬ06ｨｰ0807 ｨｪｨ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0602 09060408ｨ 09ｨｰｨ ｨｪｨｨ02 07080605ｨｨ000208ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ. 05ｨｪｨｨ0302ｨｪｨｨ02 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ090506080601ｨ 09 0908020102 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 0106 5 % ｨｪ02 0708ｨｨ090601ｨｨｨｰ ｨｺ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｰ020506ｨｬ0208ｨ 0404, ｨｨ 05ｨｰ06 0706040906050702ｨｰ 070802010706050603ｨｨｨｰｨｹ, ﾂｨｰ06 ｨ 0605ｨｹ03ｨ 07 0706 0908ｨ 09ｨｪ02ｨｪｨｨ06 0906 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ04ｨｬｨｨ ｨｮ09050609ｨｨ07ｨｬｨｨ (20 % 02 2 ) 07080605ｨｨ000208ｨ ｨｰｨｨ09ｨｪｨ 07 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 00000508 ｨｪ02 0709050702ｨｰ0907 080204ｨｮ05ｨｹｨｰｨ ｨｰ06ｨｬ ｨｨ01 ｨｰ08ｨ ｨｪ09000608ｨｬｨ 02ｨｨｨｨ. 02ｨ ｨｪｨｪ0602 ｨｪｨ ｨ 05060102ｨｪｨｨ02 09060005ｨ 09ｨｮ02ｨｰ0907 09 080204ｨｮ05ｨｹｨｰｨ ｨｰｨ ｨｬｨｨ 0108ｨｮ0006ｨｦ 0008ｨｮ070704 ｨｨ09090502010609ｨ ｨｰ020502ｨｦ, 0706ｨｺｨ 04ｨ 0903ｨｨ01, ﾂｨｰ06 09 ｨｮ09050609ｨｨ0701 0706ｨｪｨｨ0302ｨｪｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ 00000508 ｨｺ0609ｨｰｨｪ060006 ｨｬ060400ｨ, 090609020803ｨ 07 ｨ 0605ｨｹ030202 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 ｨｮ01090602ｨｪｨｨｨｦ, ｨｨｨｬ0206ｨｰ ｨｬ02ｨｪｨｹ03ｨｮ06 0105ｨｨｨｪｨｮ ｨｰ020506ｨｬ0208, ﾂ02ｨｬ 09 ｨｮ09050609ｨｨ0701 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ060006 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 (Dos Santos et al., 2010). 0806ｨｬ070502ｨｺ09ｨｪ0602 ｨｨ04ｨｮ ﾂ02ｨｪｨｨ02 07080600ｨｨ0507 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪ0609 09 00000508, ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ0401 0708ｨｨ 20 ｨｨ 5 % 02 2, 09040709ｨｨ0506 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0402 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 ｨｮ080609ｨｪ07 05ｨｺ090708020909ｨｨｨｨ 06ｨｰ010205ｨｹｨｪ0401 0002ｨｪ0609, 0708ｨｨｨｪｨｨｨｬｨ 06ｨｴｨｨ01 ｨｮ ﾂｨ 09ｨｰｨｨ02 09 09ｨ ｨｬ0401 08ｨ 0405ｨｨ ﾂｨｪ0401 09ｨｪｨｮｨｰ08ｨｨｨｺ0502ｨｰ06 ﾂｨｪ0401 07080602020909ｨ 01, 09 ｨｰ06ｨｬ ﾂｨｨ090502 ｨｨ 0002ｨｪ0609, 07080601ｨｮｨｺｨｰ04 ｨｺ06ｨｰ06080401 0708ｨｨｨｪｨｨｨｬｨ 06ｨｰ ｨ ｨｺｨｰｨｨ09ｨｪ0602 ｨｮ ﾂｨ 09ｨｰｨｨ02 09 080200ｨｮ050702ｨｨｨｨ 0708060106030102ｨｪｨｨ07 ｨｺ0502ｨｰｨｺｨ ｨｬｨｨ ｨｺ0502ｨｰ06 ﾂｨｪ060006 02ｨｨｨｺ05ｨ. 06ｨ ｨｺ, 05ｨｺ090708020909ｨｨ07 FOSB, FOSL1 ｨｨ CCND2 ｨｬ060302ｨｰ ｨｺ06090902ｨｪｨｪ06 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ090609ｨ ｨｰｨｹ 06ｨ ｨｮ ﾂｨ 09ｨｰｨｨｨｨ AP-1 09 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ 07080605ｨｨ000208ｨ 02ｨｨｨｨ 00000508 09 ｨｮ09050609ｨｨ0701 0706ｨｪｨｨ0302ｨｪｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ. 0608ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪ04ｨｦ 00ｨ ｨｺｨｰ0608 AP-1 080200ｨｮ05ｨｨ08ｨｮ02ｨｰ 05ｨｺ090708020909ｨｨ06 080701ｨ 0002ｨｪ0609 09 06ｨｰ0902ｨｰ ｨｪｨ 08ｨ 0405ｨｨ ﾂｨｪ0402 09ｨｰｨｨｨｬｨｮ0504, 09ｨｺ0506 ﾂｨ 07 02ｨｨｨｰ06ｨｺｨｨｨｪ04, 00ｨ ｨｺｨｰ060804 080609ｨｰｨ ｨｨ 09ｨｰ08020909 (Puntschart et al., 1998). 080806ｨｬ02 ｨｰ060006, ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪｨ 02ｨｨｨｺ05ｨｨｨｪｨ D (CCND2) ｨ 09090602ｨｨｨｨ080609ｨ ｨｪｨ 09 0702080201060106ｨｬ ｨｺ0502ｨｰ06ｨｺ ｨｨ04 00ｨ 0404 G 1 09 00ｨ 04ｨｮ S 02ｨｨｨｺ05ｨ ｨｨ ｨｬ060005ｨ 070806ｨｨ09010601ｨｨｨｰｨｹ 070601 0906040102ｨｦ09ｨｰ09ｨｨ02ｨｬ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪ060006 00ｨ ｨｺｨｰ0608ｨ AP-1 (Brooks et al., 1996). 07090205ｨｨ ﾂ02ｨｪｨｨ02 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪｨ 0108ｨｮ00060006 02ｨｨｨｺ05ｨｨｨｪｨ (PCNA), ｨｨ04090209ｨｰｨｪ060006 ｨｺｨ ｨｺ 07010208ｨｪ04ｨｦ ｨ ｨｪｨｰｨｨ0002ｨｪ 07080605ｨｨ000208ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｺ0502ｨｰ06ｨｺ, ｨｰ060302 ｨｬ060005ｨ 0708ｨｨ090601ｨｨｨｰｨｹ ｨｺ 0102ｨｰ02ｨｺｨｰｨｨ08ｨｮ02ｨｬ06ｨｦ ｨｪｨ ｨｬｨｨ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ 07080605ｨｨ000208ｨ 02ｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ, ｨｰｨ ｨｺ ｨｺｨ ｨｺ, 070905070709ｨｹ ｨｺ0600ｨ ｨｺｨｰ060806ｨｬ 020108-070605ｨｨｨｬ0208ｨ 0404 d, 06ｨｪ ｨｮ ﾂｨ 09ｨｰ09ｨｮ02ｨｰ 09 08020705ｨｨｨｺｨ 02ｨｨｨｨ 020108. 0604090209ｨｰｨｪ06, ﾂｨｰ06 ｨｪｨ ｨｨｨ 06050202 090408ｨ 0302ｨｪｨｪｨ 07 05ｨｺ090708020909ｨｨ07 05ｨｰ060006 ｨ 0205ｨｺｨ ｨｪｨ ﾂｨｨｨｪｨ 02ｨｰ0907 ｨｪｨ 0008ｨ ｨｪｨｨ0202 00ｨ 04 G 1 /S ｨｨ 04ｨ ｨｺｨ ｨｪ ﾂｨｨ09ｨ 02ｨｰ0907 09 ｨｺ06ｨｪ0202 S-00ｨ 0404 ｨｺ0502ｨｰ06 ﾂｨｪ060006 02ｨｨｨｺ05ｨ (Matsumoto et al., 1987). 0608ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ07 0002ｨｪｨ ｨｺｨ ｨｰｨ 05ｨｨｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 09ｨｮｨ ｨｲ0201ｨｨｨｪｨｨ0204 02ｨｨｨｺ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ06ｨｦ ｨｺｨｨｨｪｨ 0404 (CKS2) ｨｺ0608080205ｨｨ08ｨｮ02ｨｰ 09 0904070605ｨｪ02ｨｪｨｨ02ｨｬ 0206 00ｨｮｨｪｨｺ02ｨｨｨｦ 09 0607080201020502ｨｪｨｪｨｮ06 00ｨ 04ｨｮ ｨｺ0502ｨｰ06 ﾂｨｪ060006 02ｨｨｨｺ05ｨ. 0604090209ｨｰｨｪ06, ﾂｨｰ06 00ｨｬ0605 ﾂｨ ｨｪｨｨ0203 05ｨｰ060006 0002ｨｪｨ 09 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰｨ 01 0708ｨｨ090601ｨｨｨｰ ｨｺ 0609ｨｰｨ ｨｪ0609ｨｺ02 ｨｺ0502ｨｰ06 ﾂｨｪ060006 02ｨｨｨｺ05ｨ 09 00ｨ 0402 G 2 (Martinsson-Ahlzen et al., 2008). 05ｨｪｨｨ0302ｨｪｨｨ02 ｨｮ080609ｨｪ07 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪｨ ｨｨｨｪ00ｨｨｨ ｨｨｨｰ0608ｨ 02ｨｨｨｺ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ06ｨｦ ｨｺｨｨｨｪｨ 0404 (CDKN2C) 09 09090606 06 ﾂ02080201ｨｹ ｨｬ060302ｨｰ 090607080609060301ｨ ｨｰｨｹ0907 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ02ｨｦ 02ｨｨｨｺ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ0401 ｨｺｨｨｨｪｨ 04 4-0006 ｨｨ 6-0006 ｨｰｨｨ070609, 09ｨｪｨｨｨｬｨ 07 060008ｨ ｨｪｨｨ ﾂ02ｨｪｨｨ02 ｨｺ0502ｨｰ06 ﾂｨｪ060006 02ｨｨｨｺ05ｨ 09 00ｨ 0402 G 1 (Jeffrey et al., 2000). 03060106ｨ ｨｪ0402 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪ0609 0706ｨｺｨ 04ｨ ｨｪ04 ｨｨ09090502010609ｨ ｨｰ020507ｨｬｨｨ 0108ｨｮ0006ｨｦ 0008ｨｮ070704, 070601ｨｰ09020801ｨｨ0903ｨｨｨｬｨｨ, ﾂｨｰ06 ｨ ｨｺｨｰｨｨ09ｨｪｨ 07 07080605ｨｨ000208ｨ 02ｨｨ07 00000508 09 ｨｮ09050609ｨｨ0701 1%-ｨｪ06ｨｦ 00ｨｨ0706ｨｺ09ｨｨｨｨ 090607080609060301ｨ 05ｨ 09ｨｹ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02ｨｬ 05ｨｺ090708020909ｨｨｨｨ ｨｰｨ ｨｺ060006 ｨｬｨ 08ｨｺ0208ｨ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 07080605ｨｨ000208ｨ 02ｨｨｨｨ, ｨｺｨ ｨｺ 07010208ｨｪ04ｨｦ ｨ ｨｪｨｰｨｨ0002ｨｪ 07080605ｨｨ000208ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｺ0502ｨｰ06ｨｺ (PCNA). 0308ｨｨ 05ｨｰ06ｨｬ 05ｨｺ090708020909ｨｨ07 02ｨｨｨｺ05ｨｨｨｪｨ D ｨｮ090205ｨｨ ﾂｨｨ09ｨ 05ｨ 09ｨｹ 0906 090802ｨｬ02ｨｪｨｨ, ｨ 05ｨｺ090708020909ｨｨ07 ｨｨｨｪ00ｨｨｨ ｨｨｨｰ0608ｨ 02ｨｨｨｺ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ06ｨｦ ｨｺｨｨｨｪｨ 0404 p27 09ｨｪｨｨ03ｨ 05ｨ 09ｨｹ (Hung et al., 2012). 01ｨ ｨ 050601ｨ 02ｨｬ0602 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ02 ｨｮ080609ｨｪ07 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪ0609 09040409ｨ ｨｪ06 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ02ｨｦ 0607080201020502ｨｪｨｪ0401 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 07ｨｮｨｰ02ｨｦ, 06070609080201ｨｮ06ｨｴｨｨ01 05ｨｺ090708020909ｨｨ06 ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪ0401 00ｨ ｨｺｨｰ06080609 ｨｨ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ06 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ0609, ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｺ0502ｨｰ06 ﾂｨｪ04ｨｦ 02ｨｨｨｺ05. 00 08070102 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ 070601ｨｰ090208030102ｨｪ06, ﾂｨｰ06 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 07ｨｮｨｰ02ｨｦ, 06070609080201ｨｮ02ｨｬ0401 ｨｬｨｨｨｰ060002ｨｪｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ04ｨｬｨｨ 070806ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 04ｨ ｨｬｨｨ (ERK, JNK ｨｨ p38), 09 ｨｮ09050609ｨｨ0701 00ｨｨ0706ｨｺ09ｨｨｨｨ 090607080609060301ｨ 02ｨｰ0907 09ｨｰｨｨｨｬｨｮ050702ｨｨ02ｨｦ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 07080605ｨｨ000208ｨ 02ｨｨｨｨ (Laderoute, Webster, 1997; Scott et al., 1998; Kunz, Ibrahim, 2003). 06ｨ ｨｺ, ｨｬ0201ｨ ｨｪｨｨ04ｨｬ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ 07080605ｨｨ000208ｨ 02ｨｨｨｨ 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ0609 ｨｨ 0005ｨ 01ｨｺ06ｨｬ040302 ﾂｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 09 06ｨｰ0902ｨｰ ｨｪｨ ｨｪｨｨ04ｨｺｨｨｨｦ ｨｮ08060902ｨｪｨｹ ｨｺｨｨ090506080601ｨ 09 0908020102 (1 %, 30 ﾂ) 070802010706050603ｨｨｨｰ0205ｨｹｨｪ06 0609ｨｮｨｴ0209ｨｰ090507050907 07060908020109ｨｰ0906ｨｬ 09ｨｰ08020909ｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ0401 ｨｺｨｨｨｪｨ 04 JNK ｨｨ p38 ｨｨ ｨ 09090602ｨｨｨｨ080609ｨ 050907 09 0702080201060106ｨｬ ｨｺ0502ｨｰ06ｨｺ ｨｨ04 00ｨ 0404 ｨｺ0502ｨｰ06 ﾂｨｪ060006 02ｨｨｨｺ05ｨ G 1 09 00ｨ 04ｨｮ S (Scott et al., 1998). 05 0108ｨｮ0006ｨｦ 09ｨｰ060806ｨｪ04, 09ｨｰｨｨｨｬｨｮ050702ｨｨ07 07080605ｨｨ000208ｨ 02ｨｨｨｨ 0609ｨｰ0206ｨ 05ｨ 09ｨｰ0609 0708ｨｨ ｨｮｨｬ020802ｨｪｨｪ06 ｨｪｨｨ04ｨｺ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ (5 %) 09 06ｨｰ05ｨｨ ﾂｨｨ02 06ｨｰ 0108ｨｮ00ｨｨ01 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ 06ｨｺｨ 04ｨ 05ｨ 09ｨｹ 09060708070302ｨｪｨ 09 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02ｨｬ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｺ05ｨ 0909ｨｨ ﾂ0209ｨｺ060006 MAP-ｨｺｨｨｨｪｨ 04ｨｪ060006 ｨｺｨ 09ｨｺｨ 01ｨ ﾂ02080204 ｨｺｨｨｨｪｨ 0404 ERK1/2 0708ｨｨ 070609ｨｰ0607ｨｪｨｪ06ｨｬ ｨｮ080609ｨｪ02 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｺｨｨｨｪｨ 0404 p38 (Matsuda et al., 1998). 050502010609ｨ ｨｰ0205ｨｹｨｪ06, 09 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ ｨｮ09ｨｨ0502ｨｪｨｨ07 ｨｺ0502ｨｰ06 ﾂｨｪ060006 01020502ｨｪｨｨ07, 0706-09ｨｨ01ｨｨｨｬ06ｨｬｨｮ, ｨｬ0600ｨｮｨｰ ｨ 04ｨｰｨｹ 0906090502 ﾂ02ｨｪ04 ｨｺｨ ｨｺ ERK-ｨｺｨｨｨｪｨ 0404, ｨｰｨ ｨｺ ｨｨ JNK ｨｨ 0838. 0308ｨｨ 05ｨｰ06ｨｬ 09ｨｮｨｴ0209ｨｰ09ｨｮ02ｨｰ 07080201070605060302ｨｪｨｨ02 06 ｨｰ06ｨｬ, ﾂｨｰ06 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ04 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ 05ｨｰｨｨ01 ｨｺｨｨｨｪｨ 04 0708ｨｨ 09ｨｪｨｨ0302ｨｪｨｨｨｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｺｨｨ090506080601ｨ 06ｨｰ05ｨｨ ﾂｨ 06ｨｰ0907 06ｨｰ ｨｬ0201ｨ ｨｪｨｨ04ｨｬ0609, 0102ｨｦ09ｨｰ09ｨｮ06ｨｴｨｨ01 09 0905ｨｮ ﾂｨ 02 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ 07080605ｨｨ000208ｨ 02ｨｨｨｨ 080609ｨｰ060904ｨｬｨｨ 00ｨ ｨｺｨｰ0608ｨ ｨｬｨｨ 090409060806ｨｰｨｺｨｨ (Das et al., 2001). 00 ｨｪ02ｨｺ06ｨｰ06080401 ｨｨ09090502010609ｨ ｨｪｨｨ0701 090409ｨｺｨ 040409ｨ 02ｨｰ0907 07080201070605060302ｨｪｨｨ02 06 ｨｰ06ｨｬ, ﾂｨｰ06 07080605ｨｨ000208ｨ ｨｰｨｨ09ｨｪｨ 07 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 00000508 03ｨｨ08060906ｨｦ ｨｰｨｺｨ ｨｪｨｨ ｨｰ060302 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ 09090704ｨ ｨｪｨ 09 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ02ｨｦ 05ｨｰｨｨ01 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 ｨｺｨ 09ｨｺｨ 010609 (Lee et al., 2011; Zonca et al., 2012). 06ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 00000508 03ｨｨ08060906ｨｦ ｨｰｨｺｨ ｨｪｨｨ ﾂ0205060902ｨｺｨ 09 ｨｮ09050609ｨｨ0701 0706ｨｪｨｨ0302ｨｪｨｪ060006 090601020803ｨ ｨｪｨｨ07 ｨｺｨｨ090506080601ｨ ｨｨ04ｨｬ02ｨｪ0706ｨｰ 090906ｨｨ ｨｬ0608000600ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0402 090906ｨｦ09ｨｰ09ｨ, ﾂｨｰ06 0708060709050702ｨｰ0907 09 ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨｨｨ 08ｨ 04ｨｬ02080609 ｨｨ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｨ 000608ｨｬ04 ｨｺ0502ｨｰ06ｨｺ, ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ 07080605ｨｨ000208ｨ 02ｨｨｨｨ, ｨｺ06ｨｰ0608ｨ 07, 0706 090902ｨｦ 09ｨｨ01ｨｨｨｬ0609ｨｰｨｨ, ｨｪ02 0709050702ｨｰ0907 080204ｨｮ05ｨｹｨｰｨ ｨｰ06ｨｬ ｨｰ08ｨ ｨｪ09000608ｨｬｨ 02ｨｨｨｨ ｨｺ0502ｨｰ06ｨｺ, 0708ｨｨ09060107ｨｴ02ｨｦ ｨｺ ｨｪ02060008ｨ ｨｪｨｨ ﾂ02ｨｪｨｪ06ｨｬｨｮ 080609ｨｰｨｮ ｨｺｨｮ05ｨｹｨｰｨｮ0804, 0601ｨｪｨ ｨｺ06 090607080609060301ｨ 02ｨｰ0907 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ02ｨｬ 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪ0609, ｨｺ0601ｨｨ08ｨｮ06ｨｴｨｨ01 080200ｨｮ0507ｨｰ060804 ｨｺ0502ｨｰ06 ﾂｨｪ060006 02ｨｨｨｺ05ｨ. 04ｨ ｨ 06ｨｰｨ 0904070605ｨｪ02ｨｪｨ 0708ｨｨ 00ｨｨｨｪｨ ｨｪ09060906ｨｦ 07060101020803ｨｺ02 0308060008ｨ ｨｬｨｬ04 02080800 040801. 0507ｨｨ0906ｨｺ 05ｨｨｨｰ0208ｨ ｨｰｨｮ0804 09ｨｮ08ｨ 09ｨｺ0609ｨ 09. 09., 08ｨｪ0601ｨｨｨｪｨ 03. 09. 2007. 0005ｨｨ07ｨｪｨｨ02 00ｨｨ0706ｨｺ09ｨｨｨｨ ｨｪｨ 09ｨｰ0806ｨｬｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ-07080201030209ｨｰ0902ｨｪｨｪｨｨｨｺｨｨ ｨｨ04 ｨｺ0609ｨｰｨｪ060006 ｨｬ060400ｨ ｨｺ080409 ｨｪｨ 08ｨ ｨｪｨｪｨｨ01 05ｨｰｨ 07ｨ 01 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07. 090605. 05ｨｺ09070208ｨｨｨｬ. ｨ ｨｨ0605. ｨｬ0201. 4 : 386 ｪ389. 09ｨｮ08ｨ 09ｨｺ0609ｨ 09. 09., 0108ｨｨｨｪｨ ｨｺ060909ｨｺｨ 07 02. 05., 08ｨｪ0108020209ｨ 03. 04., 04ｨ ｨｬｨ ｨ 050609ｨ 08. 03., 080604ｨｨ06ｨｪ0609ｨ 00. 03. 2009. 09ｨ 08ｨ ｨｺｨｰ0208ｨｨ09ｨｰｨｨｨｺｨ ｨｬ020402ｨｪ01ｨｨｨｬｨｪ0401 09ｨｰ0806ｨｬｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ｨｨ04 05ｨｨ0706ｨ 0907ｨｨ08ｨ ｨｰｨ ﾂ0205060902ｨｺｨ, ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ0401 0708ｨｨ 0706ｨｪｨｨ0302ｨｪｨｪ06ｨｬ 090601020803ｨ ｨｪｨｨｨｨ ｨｺｨｨ090506080601ｨ. 00ｨｨｨｰ06050600ｨｨ07. 51(1) : 5 ｪ11. 050902080209ｨ 00. 06., 020208ｨ ｨ ｨｺ0609ｨ 02. 00., 0206ｨｪ020609ｨ 02. 08. 2010. 06020506ｨｬ0208ｨ 04ｨ : 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨ, 00ｨｮｨｪｨｺ02ｨｨｨｨ ｨｨ 07ｨｮｨｰｨｨ 080200ｨｮ050702ｨｨｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ. 0709070201ｨｨ ｨ ｨｨ0605. 01ｨｨｨｬ. 50 : 155 ｪ202.