132015 000606020902010608 0606ｨｬ 57, 014 00090608010603 0801060609060206060808 02020805020407090600060108 0108 0806090402090908050604 ﾁ03090200030808, 0601080600060402000801010403 0006060200030108090200060407050200 08 01. 03. 08020106080609ｨ, 1 05. 05. 03ｨｬ0205ｨｹ07ｨｪ0609ｨ, 2 01. 04. 00ｨｨｨｪ060008ｨ 0109ｨｺｨ 07, 2, 3, * 03. 00. ﾁｨｨ ﾂ0209, 1 08. 00. 00ｨｮ0804ｨ ｨｺ0609ｨ, 1 08. 08. 08ｨｨ08ｨｨ ﾂ02ｨｪｨｺ06, 1 00. 01. 000208ｨ 02ｨｪｨｺ06, 2 08. 08. 08ｨｮｨｴ 1 1 01ｨ ｨｮ ﾂｨｪ06-ｨｨ09090502010609ｨ ｨｰ0205ｨｹ09ｨｺｨｨｨｦ ｨｨｨｪ09ｨｰｨｨｨｰｨｮｨｰ 09ｨｨ08ｨｮ0906050600ｨｨｨｨ ｨｨｨｬ. 02. 06. 0609ｨ ｨｪ060909ｨｺ060006 00ｨｨｨｪｨｨ09ｨｰ020809ｨｰ09ｨ 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07 0408, 000609ｨｺ09ｨ ; 2 0302ｨｰ0208ｨ ｨｮ080009ｨｺｨｨｨｦ ｨｨｨｪ09ｨｰｨｨｨｰｨｮｨｰ 07010208ｨｪ06ｨｦ 00ｨｨ04ｨｨｨｺｨｨ ｨｨｨｬ. 09. 03. 0806ｨｪ09ｨｰｨ ｨｪｨｰｨｨｨｪ0609ｨ, 010600 0008ｨｮ08 ﾂｨ ｨｰ060909ｨｺｨｨｨｦ ｨｨｨｪ09ｨｰｨｨｨｰｨｮｨｰ03, 05ｨ ｨｪｨｺｨｰ-0302ｨｰ0208ｨ ｨｮ0800, ｨｨ 3 08ｨ 00020108ｨ ｨ ｨｨ0600ｨｨ04ｨｨｨｺｨｨ 05.-0302ｨｰ0208ｨ ｨｮ080009ｨｺ060006 000609ｨｮ01ｨ 0809ｨｰ0902ｨｪｨｪ060006 070605ｨｨｨｰ0201ｨｪｨｨ ﾂ0209ｨｺ060006 ｨｮｨｪｨｨ09020809ｨｨｨｰ02ｨｰｨ ; * 050502ｨｺｨｰ0806ｨｪｨｪ04ｨｦ ｨ 01080209: gvinogradskaya@mail.ru 01. 03. 08020106080609ｨ ｨｨ 0108. 0005ｨｨ07ｨｪｨｨ02 ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺｨ 0106ｨｺ090608ｨｮｨ ｨｨ02ｨｨｨｪｨ ｨｪｨ 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ04 ﾂ0205060902ｨｺｨ, ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0402 02ｨｨｨｰ06ｨｬ0200ｨ 050609ｨｨ08ｨｮ0906ｨｬ 030806ｨｰｨｨ090608ｨ ｨｺ060904ｨｦ ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺ 0106ｨｺ090608ｨｮｨ ｨｨ02ｨｨｨｪ (02020805) 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ04ｨｮ02ｨｰ0907 09040906ｨｺ06ｨｦ ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｹ06, 0904040409ｨ 07 0609050603ｨｪ02ｨｪｨｨ07 09 08ｨ ｨ 06ｨｰ02 03ｨｨ04ｨｪ02ｨｪｨｪ06 09ｨ 03ｨｪ0401 060800ｨ ｨｪ0609. 02ｨ ｨｪｨｪ0401 06 0102ｨｦ09ｨｰ09ｨｨｨｨ 02020805 ｨｪｨ ｨｪ0608ｨｬｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ 060800ｨ ｨｪｨｨ04ｨｬｨ ｨｪ02010609ｨｰｨ ｨｰ06 ﾂｨｪ06. 03080201070605ｨ 00ｨ 06ｨｰ, ﾂｨｰ06 02020805 ｨｨｨｪ01ｨｮ02ｨｨ08ｨｮ02ｨｰ 00ｨｨｨ 0205ｨｹ 08ｨ ｨｺ06090401 ｨｺ0502ｨｰ06ｨｺ 07ｨｮｨｰ02ｨｬ ｨ 070607ｨｰ0604ｨ, 0601ｨｪｨ ｨｺ06 0909020102ｨｪｨｨ07 06 080605ｨｨ ｨ 0205ｨｺｨ 0873, ﾂ0502ｨｪｨ 0902ｨｬ02ｨｦ09ｨｰ09ｨ 0607ｨｮ0106050209060006 09ｨｮ07080209090608ｨ 0853, 0708ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺｨｨ 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｮ06ｨｰ. 0604090209ｨｰｨｪ06, ﾂｨｰ06 02ｨｨｨｰ06ｨｬ0200ｨ 050609ｨｨ08ｨｮ09 (000000) ｨｨｨｪ01ｨｮ02ｨｨ08ｨｮ02ｨｰ ｨ ｨｪｨｰｨｨｨ 070607ｨｰ0604ｨｪｨｮ06 0708060008ｨ ｨｬｨｬｨｮ, 0706040906050706ｨｴｨｮ06 09ｨｨ08ｨｮ09ｨｮ 0609ｨｮｨｴ0209ｨｰ09ｨｨｨｰｨｹ 08020705ｨｨｨｺｨ 02ｨｨ06 090906020006 0002ｨｪ06ｨｬｨ 0106 00ｨｨｨ 0205ｨｨ ｨｺ0502ｨｰｨｺｨｨ-ｨｬｨｨ0302ｨｪｨｨ. 000205ｨｹ ｨｪｨ 09ｨｰ0607ｨｴ02ｨｦ 08ｨ ｨ 06ｨｰ04 090609ｨｰ060705ｨ 09 ｨｨ04ｨｮ ﾂ02ｨｪｨｨｨｨ 0102ｨｦ09ｨｰ09ｨｨ07 02020805 ｨｪｨ ｨｪ0608ｨｬｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ, ｨ ｨｪｨ 05ｨｨ0402 0907060906ｨ ｨｪ0609ｨｰｨｨ ｨ ｨｪｨｰｨｨｨ 070607ｨｰ0604ｨｪ06ｨｦ 0708060008ｨ ｨｬｨｬ04, 04ｨ 07ｨｮ09ｨｺｨ 02ｨｬ06ｨｦ 000000, 06ｨｺｨ 040409ｨ ｨｰｨｹ 0905ｨｨ07ｨｪｨｨ02 ｨｪｨ ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｹ 02020805 ｨｨ 09 060202ｨｪｨｺ02 ｨｮ ﾂｨ 09ｨｰｨｨ07 ｨ 0205ｨｺｨ 0873 ｨｨ 020006 ｨｨ0406000608ｨｬ 09 080200ｨｮ050702ｨｨｨｨ 00ｨｨｨ 0205ｨｨ ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 070601 0102ｨｦ09ｨｰ09ｨｨ02ｨｬ 02020805. 03060109 ﾂ02ｨｰ ｨｺ0502ｨｰ06ｨｺ 09 02ｨｨｨｰ06050600ｨｨ ﾂ0209ｨｺｨｨ01 07080207ｨ 08ｨ ｨｰｨ 01 0706ｨｺｨ 04ｨ 05, ﾂｨｰ06 09 ｨｰ02 ﾂ02ｨｪｨｨ02 24 ﾂ 02020805 0904040409ｨ 02ｨｰ 00ｨｨｨ 0205ｨｹ 06ｨｺ060506 70 % 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ0609 050200ｨｺ060006 05ｨｬｨ 08ｨｨ06ｨｪｨ ﾂ0205060902ｨｺｨ (080906 ﾁ) 09 ｨｺｨｮ05ｨｹｨｰｨｮ0802 in vitro, ｨ 0708ｨｨ 0906 ﾂ02ｨｰｨ ｨｪｨｪ06ｨｬ 0102ｨｦ09ｨｰ09ｨｨｨｨ 02020805 ｨｨ 000000 00ｨｨｨ 0205ｨｹ ｨｺ0502ｨｰ06ｨｺ ｨｮｨｬ02ｨｪｨｹ03ｨ 02ｨｰ0907. 0002ｨｰ060106ｨｬ TUNEL 0607080201020502ｨｪ06, ﾂｨｰ06 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 ｨｺ0502ｨｰ06ｨｺ 09 08ｨ 04080409ｨ ｨｬｨｨ 020108 0708ｨｨ 0102ｨｦ09ｨｰ09ｨｨｨｨ 02020805 09ｨｪｨｨ03ｨ 02ｨｰ0907 09 5.2 0106 3.2 % (P < 0.05) 0708ｨｨ 0906040102ｨｦ09ｨｰ09ｨｨｨｨ ｨｪｨ 000000-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ. 08ｨｪｨ 05ｨｨ04 ｨｬｨｨｨｰ06ｨｰｨｨ ﾂ0209ｨｺｨｨ01 00ｨｨ00ｨｮ08 09040709ｨｨ05 ｨｪｨ ｨｺ06070502ｨｪｨｨ02 ｨｺ0502ｨｰ06ｨｺ 09 ｨｬｨｨｨｰ060402 070601 0102ｨｦ09ｨｰ09ｨｨ02ｨｬ 02020805, ｨｰ060001ｨ ｨｺｨ ｨｺ 09 ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 000000 ｨｺ0502ｨｰｨｺｨ 01 07060106ｨ ｨｪ060006 07090502ｨｪｨｨ07 ｨｪ02 ｨｪｨ ｨ 050601ｨ 05ｨｨ. 08ｨｪｨ 05ｨｨ04 ｨｬ040108 0109ｨｮ01 ｨｨ0406000608ｨｬ ｨ 0205ｨｺｨ 0873 (06080873 ｨｨ dnp73) 0706ｨｺｨ 04ｨ 05, ﾂｨｰ06 09 ｨｪ02ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 ｨｺ0502ｨｰｨｺｨ 01 05ｨｺ090708020909ｨｨ07 ｨｨ0406000608ｨｬ04 06080873 06 ﾂ02ｨｪｨｹ ｨｪｨｨ04ｨｺｨ 07, ｨｰ060001ｨ ｨｺｨ ｨｺ 09 000000-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 080906 ﾁ ｨｮ08060902ｨｪｨｹ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨｨｨ ｨｨ0406000608ｨｬ04 06080873 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06 070609040302ｨｪ, ｨｨ 09070208090402 06ｨ ｨｪｨ 08ｨｮ0302ｨｪｨ 05ｨｺ090708020909ｨｨ07 ｨｨ0406000608ｨｬ04 dn0873. 00 ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 ｨｺ0502ｨｰｨｺｨ 01, 06ｨ 08ｨ ｨ 06ｨｰｨ ｨｪｨｪ0401 02020805, ｨｪ02 070806ｨｨ09010601ｨｨ0506 ｨ 0506ｨｺｨ ｨｬｨｨｨｰ0604ｨ, ｨｪ06 ｨｪｨ ｨ 050601ｨ 05ｨ 09ｨｹ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 ｨｺｨ 0907ｨ 04 8, 9 ｨｨ 3, ｨｺ06ｨｰ0608ｨ 07 090607080609060301ｨ 05ｨ 09ｨｹ 00ｨｨｨ 0205ｨｹ06 ｨｺ0502ｨｰ06ｨｺ, 0601ｨｪｨ ｨｺ06 ｨｪ02 09ｨｰ0605ｨｹ ｨｬｨ 0909060906ｨｦ, ｨｺｨ ｨｺ 0708ｨｨ 0102ｨｦ09ｨｰ09ｨｨｨｨ 02020805. 030605ｨｮ ﾂ02ｨｪｨｪ0402 01ｨ ｨｪｨｪ0402 0706040906050706ｨｰ 04ｨ ｨｺ0506 ﾂｨｨｨｰｨｹ, ﾂｨｰ06 000000 060905ｨ ｨ 050702ｨｰ 07060908020301ｨ 06ｨｴ0202 0102ｨｦ09ｨｰ09ｨｨ02 02020805 ｨｪｨ ｨｪ0608ｨｬｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ. 000603ｨｪ06 070802010706050603ｨｨｨｰｨｹ, ﾂｨｰ06 ｨｨｨｪ01ｨｮｨｺ02ｨｨ07 06080873 ｨｨ 070607090502ｨｪｨｨ02 ｨｮｨｺ060806 ﾂ02ｨｪｨｪ06ｨｦ ｨｨ0406000608ｨｬ04 0873 09060401ｨ 06ｨｰ ｨｮ09050609ｨｨ07 010507 ｨ ｨｰｨｰ02ｨｪｨｮｨ 02ｨｨｨｨ 0905ｨｨ07ｨｪｨｨ07 02020805 ｨｪｨ 0706090802030102ｨｪｨｨ02 020108 ｨｨ 00ｨｨｨ 0205ｨｹ ｨｪ0608ｨｬｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ. 080506 ﾂ02090402 09050609ｨ : 0106ｨｺ090608ｨｮｨ ｨｨ02ｨｨｨｪ, 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ04 ﾂ0205060902ｨｺｨ, 02ｨｨｨｰ06ｨｬ0200ｨ 050609ｨｨ08ｨｮ09, ｨｨ0406000608ｨｬ04 06080873 ｨｨ dnp73 ｨ 0205ｨｺｨ 0873. 0308ｨｨｨｪ07ｨｰ0402 0906ｨｺ08ｨ ｨｴ02ｨｪｨｨ07: 02020805 ｪ 0106ｨｺ090608ｨｮｨ ｨｨ02ｨｨｨｪ, 000000 ｪ 02ｨｨｨｰ06ｨｬ0200ｨ 050609ｨｨ08ｨｮ09, 080906 ﾁ ｪ 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ04 050200ｨｺ060006 05ｨｬｨ 08ｨｨ06ｨｪｨ ﾂ0205060902ｨｺｨ. 02020805 ｪ 070806ｨｰｨｨ090608ｨ ｨｺ060904ｨｦ ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺ, ｨ 06050202 40 0502ｨｰ 0708ｨｨｨｬ02ｨｪ0702ｨｬ04ｨｦ 010507 0502 ﾂ02ｨｪｨｨ07 03ｨｨ0806ｨｺ060006 090702ｨｺｨｰ08ｨ 06ｨｪｨｺ06050600ｨｨ ﾂ0209ｨｺｨｨ01 04ｨ ｨ 06050209ｨ ｨｪｨｨｨｦ. 030006 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ04ｨｬ ｨｪ02010609ｨｰｨ ｨｰｨｺ06ｨｬ 0709050702ｨｰ0907 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪｨ 07 ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｹ, ｨｺ06ｨｰ0608ｨ 07 0708ｨｨ090601ｨｨｨｰ ｨｺ 0609050603ｨｪ02ｨｪｨｨ07ｨｬ 09 08ｨ ｨ 06ｨｰ02 0902080102ｨ ｨｨ 0702 ﾂ02ｨｪｨｨ, ｨｺ 0706ｨｰ020802 0905ｨｮ01ｨ ｨｨ 0108ｨｮ00ｨｨｨｬ 07ｨ ｨｰ06050600ｨｨ07ｨｬ. 00 ｨｪｨ 09ｨｰ0607ｨｴ0202 090802ｨｬ07 090201ｨｮｨｰ0907 ｨｨｨｪｨｰ02ｨｪ09ｨｨ09ｨｪ0402 ｨｨ09090502010609ｨ ｨｪｨｨ07, ｨｪｨ 0708ｨ 090502ｨｪｨｪ0402 ｨｪｨ 0706ｨｨ09ｨｺ 0908020109ｨｰ09, 09ｨｪｨｨ03ｨ 06ｨｴｨｨ01 ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｹ ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺｨ ｨｨ 0706090403ｨ 06ｨｴｨｨ01 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ ｨｺ ｨｪ02ｨｬｨｮ (Wang et al., 2014; Yu et al., 2014), ｨｺ06ｨｰ06080402 0706ｨｺｨ ｨｪ02 0708ｨｨ090205ｨｨ ｨｺ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ04ｨｬ ｨｮ09070201ｨ ｨｬ. 0201ｨｪｨ ｨｨ04 0708ｨｨ ﾂｨｨｨｪ 090609ｨｰ06ｨｨｨｰ 09 ｨｪ02010609ｨｰｨ ｨｰ06 ﾂｨｪ06ｨｦ ｨｨ04ｨｮ ﾂ02ｨｪｨｪ0609ｨｰｨｨ 0102ｨｦ09ｨｰ09ｨｨ07 02020805 ｨｪｨ ｨｪ020607ｨｮ01060502090402 ｨｺ0502ｨｰｨｺｨｨ 09 ｨｰｨｺｨ ｨｪ0701, 06ｨｺ08ｨｮ03ｨ 06ｨｴｨｨ01 0607ｨｮ010605ｨｹ, 09 090208010202, 0702 ﾂ02ｨｪｨｨ ｨｨ 060800ｨ ｨｪｨｨ04ｨｬ02 09 02020506ｨｬ. 0604ｨｮ ﾂ02ｨｪｨｨ02 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ0609 070806ｨｰｨｨ09060607ｨｮ0106050209060006 0102ｨｦ09ｨｰ09ｨｨ07 ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺｨ 0708ｨｨ09020506 ｨｺ 04ｨ ｨｺ0506 ﾂ02ｨｪｨｨ06 06 ｨｰ06ｨｬ, ﾂｨｰ06 02020805 ｨｨｨｪ01ｨｮ02ｨｨ08ｨｮ02ｨｰ 00ｨｨｨ 0205ｨｹ ｨｺ0502ｨｰ06ｨｺ 07ｨｮｨｰ02ｨｬ ｨ 070607ｨｰ0604ｨ 09 ｨｮ ﾂｨ 09ｨｰｨｨ02ｨｬ ｨ 0205ｨｺｨ 0853, 0601ｨｪｨ ｨｺ06 ｨｨｨｬ0206ｨｴｨｨ020907 01ｨ ｨｪｨｪ0402 070806ｨｰｨｨ09060802 ﾂｨｨ0904, ｨ 06 080605ｨｨ 0108ｨｮ00ｨｨ01 ｨ 0205ｨｺ0609 05ｨｰ060006 0902ｨｬ02ｨｦ09ｨｰ09ｨ 09 02020805-ｨｨｨｪ01ｨｮ02ｨｨ080609ｨ ｨｪｨｪ06ｨｬ ｨ 070607ｨｰ060402 0909020102ｨｪｨｨ07 ｨｪ02ｨｬｨｪ060006 ﾂｨｨ090502ｨｪｨｪ04 (Minotti et al., 2004). 00 ｨｰ06 0302 090802ｨｬ07 0706ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨ 020506ｨｺ 0873 ｪ ﾂ0502ｨｪ 0902ｨｬ02ｨｦ09ｨｰ09ｨ 070806ｨｰｨｨ09060607ｨｮ01060502090401 ｨ 0205ｨｺ0609 0853 ｪ ｨｮ ﾂｨ 09ｨｰ09ｨｮ02ｨｰ 09 080200ｨｮ050702ｨｨｨｨ ｨｺ0502ｨｰ06 ﾂｨｪ060006 01020502ｨｪｨｨ07 ｨｨ 00ｨｨｨ 0205ｨｨ ｨｺ0502ｨｰ06ｨｺ, ｨｨｨｬ0202ｨｰ ｨｪ0209ｨｺ0605ｨｹｨｺ06 ｨｨ0406000608ｨｬ, ｨｺ06ｨｰ06080402 ｨｬ0600ｨｮｨｰ 06ｨｺｨ 040409ｨ ｨｰｨｹ ｨｺｨ ｨｺ 070806ｨ 070607ｨｰ0604ｨｪ0602, ｨｰｨ ｨｺ ｨｨ 06ｨｪｨｺ060002ｨｪｨｪ0602 0102ｨｦ09ｨｰ09ｨｨ02. 0604090209ｨｰｨｪ06, ﾂｨｰ06 000000 ﾂ0205060902ｨｺｨ, 070607ｨ 01ｨ 07 09 ｨｺ0502ｨｰｨｺｨｮ, ｨｨｨｪ01ｨｮ02ｨｨ08ｨｮ02ｨｰ ｨ ｨｪｨｰｨｨｨ 070607ｨｰ0604ｨｪｨｮ06 0708060008ｨ ｨｬｨｬｨｮ, 0706040906050706ｨｴｨｮ06 09ｨｨ08ｨｮ09ｨｮ 0609ｨｮｨｴ0209ｨｰ09ｨｨｨｰｨｹ 08020705ｨｨｨｺｨ 02ｨｨ06 09090602-260
130005ｨｨ07ｨｪｨｨ02 ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺｨ 0106ｨｺ090608ｨｮｨ ｨｨ02ｨｨｨｪｨ ｨｪｨ 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ04 ﾂ0205060902ｨｺｨ, ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0402 02ｨｨｨｰ06ｨｬ0200ｨ 050609ｨｨ08ｨｮ0906ｨｬ 261 0006 0002ｨｪ06ｨｬｨ 0106 00ｨｨｨ 0205ｨｨ ｨｺ0502ｨｰｨｺｨｨ-ｨｬｨｨ0302ｨｪｨｨ. 0308020109ｨｰｨ 0905070506 ｨｨｨｪｨｰ02080209 09040709ｨｪｨｨｨｰｨｹ, 0907060906ｨ ｨｪｨ 05ｨｨ ｨ ｨｪｨｰｨｨｨ 070607ｨｰ0604ｨｪｨ 07 0708060008ｨ ｨｬｨｬｨ, 04ｨ 07ｨｮ09ｨｺｨ 02ｨｬｨ 07 000000, 06ｨｺｨ 040409ｨ ｨｰｨｹ 0905ｨｨ07ｨｪｨｨ02 ｨｪｨ ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｹ 02020805 09 06ｨｰｨｪ060302ｨｪｨｨｨｨ ｨｪ0608ｨｬｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ｪ 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ0609 ﾂ0205060902ｨｺｨ, ｨ ｨｰｨ ｨｺ0302 ｨｺｨ ｨｺ060906 ｨｮ ﾂｨ 09ｨｰｨｨ02 ｨ 0205ｨｺｨ 0873 ｨｨ 020006 ｨｨ0406000608ｨｬ 09 080200ｨｮ050702ｨｨｨｨ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 00ｨｨｨ 0205ｨｨ 070601 0102ｨｦ09ｨｰ09ｨｨ02ｨｬ 02020805 09 ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 ｨｺ0502ｨｰｨｺｨ 01. 02ｨｰ0902ｨｰ04 ｨｪｨ 070609ｨｰｨ 090502ｨｪｨｪ0402 09060708060904 0106070605ｨｪ07ｨｰ ｨｨｨｬ0206ｨｴｨｨ020907 0909020102ｨｪｨｨ07 06 ｨｬ0201ｨ ｨｪｨｨ04ｨｬｨ 01 0102ｨｦ09ｨｰ09ｨｨ07 ｨｨ ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｨ 02020805, ｨ ｨｰｨ ｨｺ0302 0706ｨｬ0600ｨｮｨｰ 09 08ｨ 0408ｨ ｨ 06ｨｰｨｺ02 ｨｪ06090401 09ｨｰ08ｨ ｨｰ0200ｨｨｨｦ 0502 ﾂ02ｨｪｨｨ07 06ｨｪｨｺ0604ｨ ｨ 06050209ｨ ｨｪｨｨｨｦ. 00ｨ ｨｰ0208ｨｨｨ 05 ｨｨ ｨｬ02ｨｰ0601ｨｨｨｺｨ 08 05 02 ｨｰ ｨｺ ｨｨ. 02ｨ ｨｲ02ｨｺｨｰ06ｨｬ ｨｨ09090502010609ｨ ｨｪｨｨ07 0905ｨｮ03ｨｨ05ｨｨ 01ｨｨ070506ｨｨ01ｨｪ0402 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ04 050200ｨｺ060006 05ｨｬｨ 08ｨｨ06ｨｪｨ ﾂ0205060902ｨｺｨ (080906 ﾁ), 070605ｨｮ ﾂ02ｨｪｨｪ0402 ｨｨ04 ｨｺ06050502ｨｺ02ｨｨｨｨ ｨｺ0502ｨｰ06 ﾂｨｪ0401 05ｨｨｨｪｨｨｨｦ 01ｨ ｨｮ ﾂｨｪ06-ｨｨ09090502010609ｨ ｨｰ0205ｨｹ09ｨｺ060006 ｨｨｨｪ09ｨｰｨｨｨｰｨｮｨｰｨ 09ｨｨ08ｨｮ0906050600ｨｨｨｨ ｨｨｨｬ. 02. 06. 0609ｨ ｨｪ060909ｨｺ060006 00ｨｨｨｪｨｨ09ｨｰ020809ｨｰ09ｨ 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07 0408 (000609ｨｺ09ｨ ). 08ｨｮ05ｨｹｨｰｨｮ08ｨｮ ｨｺ0502ｨｰ06ｨｺ 090408ｨ ｨｴｨｨ09ｨ 05ｨｨ ｨｪｨ 0908020102 02000300, 090601020803ｨ ｨｴ02ｨｦ 10 % 05ｨｬｨ 08ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨｰ020507 ﾂｨｹ02ｨｦ 090409060806ｨｰｨｺｨｨ (060605), 2 ｨｬ00 L-0005ｨｮｨｰｨ ｨｬｨｨｨｪｨ ｨｨ 50 ｨｬｨｺ00/ｨｬ05 0002ｨｪｨｰｨ ｨｬｨｨ02ｨｨｨｪｨ (03ｨ ｨｪ06ｨｺ06, 04060909ｨｨ07). 00ｨｨ08ｨｮ09. 0609070605ｨｹ040609ｨ 05ｨｨ 080200020802ｨｪ09-03ｨｰｨ ｨｬｨｬ 000000 AD 169, 0506ｨ 0204ｨｪ06 070802010609ｨｰｨ 090502ｨｪｨｪ04ｨｦ 01-0806ｨｬ 02. 06ｨｬｨ ｨｪｨｮ0505ｨｹ (D. Emanuel, 050108). 00ｨｨ08ｨｮ09 08ｨ 04ｨｬｨｪ0603ｨ 05ｨｨ 07ｨｮｨｰ02ｨｬ 07ｨ 0909ｨｨ080609ｨ ｨｪｨｨ07 ｨｪｨ ｨｺｨｮ05ｨｹｨｰｨｮ0802 ｨｺ0502ｨｰ06ｨｺ 080906 ﾁ. 08ｨｨｨ 0806ｨ 05ｨ 09ｨｰ04 04ｨ 08ｨ 03ｨ 05ｨｨ 09 ｨｨｨｪ0002ｨｺ02ｨｨ06ｨｪｨｪ06ｨｦ ｨｬｨｪ06030209ｨｰ0902ｨｪｨｪ0609ｨｰｨｹ06 3 ｪ5 090203/ｨｺ05. 0801090608ｨ 02ｨｨ06 09ｨｨ08ｨｮ09ｨ 070806090601ｨｨ05ｨｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 1 ﾂ 0708ｨｨ 37 縺05, 04ｨ ｨｰ02ｨｬ 09ｨｨ08ｨｮ0906090601020803ｨ ｨｴｨｮ06 03ｨｨ01ｨｺ0609ｨｰｨｹ 06ｨｰｨｬ0409ｨ 05ｨｨ ｨｨ 09ｨｪ0609ｨｨ05ｨｨ 07060101020803ｨｨ09ｨ 06ｨｴｨｮ06 09080201ｨｮ ｪ 02000300 09 2 % 060605. 02ｨ 08ｨ ｨ 06ｨｰｨｺｨ 080906 ﾁ ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺ06ｨｬ.080502ｨｰｨｺｨｨ 090409ｨ 03ｨｨ09ｨ 05ｨｨ 09 ｨｺｨｮ05ｨｹｨｰｨｮ08ｨ 05ｨｹｨｪ0402 0005ｨ ｨｺ06ｨｪ04 (Coster, 050108) ｨｨ05ｨｨ 09 24-05ｨｮｨｪ06 ﾂｨｪ0402 07ｨ ｨｪ0205ｨｨ (Corning, 050108) 09 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ 200 ｨｰ0409. ｨｺ0502ｨｰ06ｨｺ ｨｪｨ 1 ｨｬ05 0908020104 ｨｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ 05ｨｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 48 ﾂ 0708ｨｨ 37 縺05 09 ｨ ｨｰｨｬ060900020802 5 % 0502 2. 02020805 C 27 H 29 NO 11 (Sigma, 050108) 09ｨｪ0609ｨｨ05ｨｨ 09 ｨｺｨｮ05ｨｹｨｰｨｮ08ｨｮ 080906 ﾁ 09 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ 5 ｨｬｨｺ00/ｨｬ05 ｨｨ ｨｨｨｪｨｺｨｮｨ ｨｨ080609ｨ 05ｨｨ 8 ｨｨ05ｨｨ 24 ﾂ. 0202ｨｦ09ｨｰ09ｨｨ02 02020805 ｨｪｨ 080906 ﾁ 060202ｨｪｨｨ09ｨ 05ｨｨ 09 0802ｨ ｨｺ02ｨｨ0701, 0607ｨｨ09ｨ ｨｪｨｪ0401 ｨｪｨｨ0302. 02ｨ 08ｨ ｨ 06ｨｰｨｺｨ 02020805 000000-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ. 080502ｨｰｨｺｨｨ 080906 ﾁ 090409ｨ 03ｨｨ09ｨ 05ｨｨ 09 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ 200 ｨｰ0409. ｨｺ0502ｨｰ06ｨｺ 09 1 ｨｬ05 0908020104 ｨｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ 05ｨｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 24 ﾂ, ｨｺｨ ｨｺ 0607ｨｨ09ｨ ｨｪ06 09040302. 05ｨ ｨｰ02ｨｬ 04ｨ 08ｨ 03ｨ 05ｨｨ 000000 09 ｨｨｨｪ0002ｨｺ02ｨｨ06ｨｪｨｪ06ｨｦ ｨｬｨｪ06030209ｨｰ0902ｨｪｨｪ0609ｨｰｨｹ06 3 ｪ5 090203/ｨｺ05. ﾁ02080204 24 ﾂ 0706090502 04ｨ 08ｨ 0302ｨｪｨｨ07 09 ｨｺｨｮ05ｨｹｨｰｨｮ08ｨｮ ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 0106ｨ ｨ 09050705ｨｨ 02020805 09 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ 5 ｨｬｨｺ00/ｨｬ05 ｨｨ ｨｨｨｪｨｺｨｮｨ ｨｨ080609ｨ 05ｨｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 09050201ｨｮ06ｨｴｨｨ01 24 ﾂ. 0306090502 24- ﾂｨ 09060906ｨｦ ｨｨｨｪｨｺｨｮｨ ｨ 02ｨｨｨｨ 09 02020805 ( ﾂ02080204 48 ﾂ 0706090502 04ｨ 08ｨ 0302ｨｪｨｨ07 000000) ｨｺ0502ｨｰｨｺｨｨ 06ｨｰｨｬ0409ｨ 05ｨｨ ｨｨ 070806090601ｨｨ05ｨｨ 0908ｨ 09ｨｪｨｨｨｰ0205ｨｹｨｪ0602 ｨｨ04ｨｮ ﾂ02ｨｪｨｨ02 ｨｺｨｮ05ｨｹｨｰｨｮ0804 080906 ﾁ 09 0706ｨｬ06ｨｴｨｹ06 ｨｬ02ｨｰ06010609, 0607ｨｨ09ｨ ｨｪｨｪ0401 ｨｪｨｨ0302. 00ｨｨｨｰ06ｨｰ06ｨｺ09ｨｨ ﾂ0209ｨｺ0602 0102ｨｦ09ｨｰ09ｨｨ02 02020805 060202ｨｪｨｨ09ｨ 05ｨｨ 07ｨｮｨｰ02ｨｬ 07060109 ﾂ02ｨｰｨ 080906 ﾁ 09 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ (ｨ 0204 02020805) ｨｨ 060704ｨｰｨｪ06ｨｦ (06ｨ 08ｨ ｨ 06ｨｰｨ ｨｪｨｪ06ｨｦ 02020805) 070607ｨｮ050702ｨｨ0701. 020507 05ｨｰ060006 ｨｺ0502ｨｰｨｺｨｨ 090409ｨ 03ｨｨ09ｨ 05ｨｨ 09 24-05ｨｮｨｪ06 ﾂｨｪ0402 0705ｨ ｨｪ0302ｨｰ04 09 0706ｨｺ080609ｨｪ04ｨｬｨｨ 09ｨｰ02ｨｺ05ｨ ｨｬｨｨ ｨｨ 0106ｨ ｨ 09050705ｨｨ 02020805 09 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ 5 ｨｬｨｺ00/ｨｬ05. 0306090502 24- ﾂｨ 09060906ｨｦ ｨｨｨｪｨｺｨｮｨ ｨ 02ｨｨｨｨ ｨｺ0502ｨｰｨｺｨｨ 070806ｨｬ0409ｨ 05ｨｨ 0.1 00 00060900ｨ ｨｰｨｪ06-090605020904ｨｬ ｨ ｨｮ00020806ｨｬ (0801 7.4) (080509), 04ｨ ｨｰ02ｨｬ 00ｨｨｨｺ09ｨｨ080609ｨ 05ｨｨ ｨ ｨ 09060506ｨｰｨｪ04ｨｬ ｨｬ02ｨｰｨ ｨｪ060506ｨｬ 20 ｨｬｨｨｨｪ 0708ｨｨ ｨC20 縺05. 08ｨｨｨｺ09ｨｨ080609ｨ ｨｪｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ 06ｨｺ08ｨ 03ｨｨ09ｨ 05ｨｨ 0002ｨｬｨ ｨｰ06ｨｺ09ｨｨ05ｨｨｨｪ06ｨｬ 08ｨ 08ｨ ﾂ ﾂｨｨ (090608ｨｨ0900-08090600ｨ 010806, 04060909ｨｨ07) ｨｨ 07060109 ﾂｨｨｨｰ0409ｨ 05ｨｨ 070601 ｨｬｨｨｨｺ080609ｨｺ060706ｨｬ (AxioCamMRc 5, Zeizz, 010208ｨｬｨ ｨｪｨｨ07). 03060109 ﾂｨｨｨｰ0409ｨ 05ｨｨ ｨｺ0502ｨｰｨｺｨｨ ｨｪ02 ｨｬ02ｨｪ0202 ﾂ02ｨｬ 09 10 0706050701 040802ｨｪｨｨ07 ｨｨ 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 090408ｨ 03ｨ 05ｨｨ 09 ｨｺ0605ｨｨ ﾂ0209ｨｰ0902 ｨｺ0502ｨｰ06ｨｺ ｨｪｨ 07060502 040802ｨｪｨｨ07 ｨｬｨｨｨｺ080609ｨｺ0607ｨ (06ｨｺ. 101 7, 06ｨ. 401 7). 02060506 ｨｺ0502ｨｰ06ｨｺ 09 060704ｨｰｨｪ06ｨｦ ｨｺｨｮ05ｨｹｨｰｨｮ0802 090408ｨ 03ｨ 05ｨｨ 09 0708060202ｨｪｨｰｨ 01 06ｨｰ ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ 070607ｨｮ050702ｨｨｨｨ. 02ｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨ02 ｨｬｨ 08ｨｺ02080609 ｨ 070607ｨｰ0604ｨ ｨｨ ｨ ｨｮｨｰ0600 ｨ 00 ｨｨ ｨｨ. 00 ｨｺｨ ﾂ0209ｨｰ0902 ｨｬｨ 08ｨｺ02080609 ｨ 070607ｨｰ0604ｨ 09040709050705ｨｨ ｨ ｨｺｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｪ0402 ｨｺｨ 0907ｨ 0404 3, 8 ｨｨ 9,09 ｨｺｨ ﾂ0209ｨｰ0902 ｨｬｨ 08ｨｺ0208ｨ ｨ ｨｮｨｰ0600ｨ 00ｨｨｨｨ ｪ ｨ 020506ｨｺ LCP3A/B. 030806090601ｨｨ05ｨｨ ｨｨｨｬｨｬｨｮｨｪ0602ｨｨｨｰ0601ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨｨｦ ｨ ｨｪｨ 05ｨｨ04 09 0802ｨ ｨｺ02ｨｨｨｨ ｨｪ02070807ｨｬ06ｨｦ ｨｨｨｬｨｬｨｮｨｪ060005ｨｮ060802090202ｨｪ02ｨｨｨｨ in situ 09 ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨ02ｨｬ 09070202ｨｨ00ｨｨ ﾂ0209ｨｺｨｨ01 ｨ ｨｪｨｰｨｨｨｰ0205. 080502ｨｰｨｺｨｨ 00ｨｨｨｺ09ｨｨ080609ｨ 05ｨｨ 060105ｨ 030102ｨｪｨｪ04ｨｬ ｨｬ02ｨｰｨ ｨｪ060506ｨｬ, ｨｺｨ ｨｺ ｨｮｨｺｨ 04ｨ ｨｪ06 09040302, 0706090502 070806ｨｬ0409ｨｺｨｨ 00ｨｨｨｺ09ｨｨ080609ｨ ｨｪｨｪ0401 07080207ｨ 08ｨ ｨｰ0609 080509 ｨｪｨ ｨｺ0502ｨｰｨｺｨｨ ｨｪｨ ｨｪ0609ｨｨ05ｨｨ 08ｨ 09ｨｰ090608 09070202ｨｨ00ｨｨ ﾂ0209ｨｺｨｨ01 ｨ ｨｪｨｰｨｨｨｰ0205 09 080509, 090601020803ｨ ｨｴｨｨｨｦ 1 % ｨ 04 ﾂｨｹ020006 090409060806ｨｰ06 ﾂｨｪ060006 ｨ 05ｨｹｨ ｨｮｨｬｨｨｨｪｨ (Sigma, 050108). 06ｨｪｨｺｨｮｨ ｨｨ080609ｨ 05ｨｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 1 ﾂ 0708ｨｨ 37 縺05. 020507 090407090502ｨｪｨｨ07 ｨｺｨ 0907ｨ 04 ｨｨ09070605ｨｹ040609ｨ 05ｨｨ ｨ ｨｪｨｰｨｨｨｰ0205ｨ ｨｺ ｨｺｨ 0907ｨ 0402 3 (ab52293, Abcam, 000205ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨ07) ｨｨ ｨｺｨ 0907ｨ 0402 8 (ab4052, Abcam, 000205ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨ07) 09 08ｨ 0409020102ｨｪｨｨｨｨ 1 : 50 ｨｨ ｨ ｨｪｨｰｨｨｨｰ0205ｨ ｨｺ ｨｺｨ 0907ｨ 0402 9 (ab32539, Abcam, 000205ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨ07) 09 08ｨ 0409020102ｨｪｨｨｨｨ 1 : 100. 020507 090407090502ｨｪｨｨ07 ｨｬｨ 08ｨｺ0208ｨ ｨ ｨｮｨｰ0600ｨ 00ｨｨｨｨ ｨｨ09070605ｨｹ040609ｨ 05ｨｨ ｨ ｨｪｨｰｨｨｨｰ0205ｨ ｨｺ ｨ 0205ｨｺｨｮ LC3A/B (ab58610, Abcam, 000205ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨ07) 09 08ｨ 0409020102ｨｪｨｨｨｨ 1 : 50. 0306090502 ｨｨｨｪｨｺｨｮｨ ｨ 02ｨｨｨｨ 09 0702080904ｨｬｨｨ ｨ ｨｪｨｰｨｨｨｰ0205ｨ ｨｬｨｨ ｨｺ0502ｨｰｨｺｨｨ 070806ｨｬ0409ｨ 05ｨｨ ｨｨ ｨｨｨｪｨｺｨｮｨ ｨｨ080609ｨ 05ｨｨ 0906 09ｨｰ060804ｨｬｨｨ ｨ ｨｪｨｰｨｨｨｰ0205ｨ ｨｬｨｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 30 ｨｬｨｨｨｪ 0708ｨｨ 37 縺05. 00 ｨｺｨ ﾂ0209ｨｰ0902 09ｨｰ06080401 ｨ ｨｪｨｰｨｨｨｰ0205 ｨｨ09070605ｨｹ040609ｨ 05ｨｨ ｨｺ0604ｨｹｨｨ ｨ ｨｪｨｰｨｨｨｺ080605ｨｨ ﾂｨｹｨｨ 070605ｨｨｨｺ0506ｨｪｨ 05ｨｹｨｪ0402 ｨ ｨｪｨｰｨｨｨｰ0205ｨ, ｨｺ06ｨｪｨｲ0600ｨｨ080609ｨ ｨｪｨｪ0402 09 0005ｨｮ060806010806ｨｬ06ｨｬ 08060600 (ab98502, Abcam, 000205ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨ07), 09 08ｨ 0409020102ｨｪｨｨｨｨ 1 : 100. 080108ｨ ｨｺ0502ｨｰ06ｨｺ 06ｨｺ08ｨ 03ｨｨ09ｨ 05ｨｨ 020108-ｨｰ080607ｨｪ04ｨｬ ｨｺ08ｨ 09ｨｨｨｰ020502ｨｬ DAPI (Sigma, 050108) 09 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ 1 ｨｬｨｺ00/ｨｬ05. 03080207ｨ 08ｨ ｨｰ04 09 ｨｺ0502ｨｰｨｺｨ ｨｬｨｨ 04ｨ ｨｺ0506 ﾂｨ 05ｨｨ 09 ｨｬ0609ｨｨ0605 (Calbiochem, 050108) ｨｨ 07080609ｨｬｨ ｨｰ08ｨｨ09ｨ 05ｨｨ 09 0005ｨｮ060802090202ｨｪｨｰｨｪ06ｨｬ ｨｬｨｨｨｺ080609ｨｺ060702 (AxioCamMRc 5, Zeizz, 010208ｨｬｨ ｨｪｨｨ07, 06ｨｺ. 101 7, 06ｨ. 1001 7). 000407090502ｨｪｨｨ02 0008ｨ 00ｨｬ02ｨｪｨｰｨｨ080609ｨ ｨｪｨｪ06ｨｦ 020108. 020507 06ｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 08ｨ 040804090609 09 020108 ｨｨ09070605ｨｹ040609ｨ 05ｨｨ ｨｬ02ｨｰ0601 TUNEL. 080502ｨｰｨｺｨｨ 00ｨｨｨｺ09ｨｨ080609ｨ 05ｨｨ ｨｨ 06ｨｺ08ｨ 03ｨｨ09ｨ 05ｨｨ 09 0706ｨｬ06ｨｴｨｹ06 ｨｪｨ ｨ 0608ｨ 0802ｨ 0002ｨｪｨｰ0609 Dead End6ｾ4 Colorimetric TUNEL System (Promega, 050108). 0402ｨ ｨｺ02ｨｨ06 070806090601ｨｨ05ｨｨ 09060005ｨ 09ｨｪ06 070806ｨｰ06ｨｺ0605ｨｮ 00ｨｨ08ｨｬ04-070806ｨｨ04090601ｨｨｨｰ020507. 000401020502ｨｪｨｨ02 040108 ｨｨ 0206-030004 09 080203ｨｨｨｬ02 0802ｨ 05ｨｹｨｪ060006 090802ｨｬ02ｨｪｨｨ (TaqMan). 02ｨ ｨｴｨｮ06 040108 (0708ｨｨｨｬ0208ｨｪ06 ｨｨ04 2 ｨｬ05ｨｪ ｨｺ0502ｨｰ06ｨｺ) 09040102050705ｨｨ 09 0706ｨｬ06ｨｴｨｹ06 ｨｪｨ ｨ 0608ｨ Aurum Total RNA Minikit (BioRad, 050108) 09 0106ｨ ｨ 090502ｨｪｨｨ02ｨｬ 020108ｨ 0404 I (BioRad, 050108) 010507 01020008ｨ 01ｨ 02ｨｨｨｨ 0002ｨｪ06ｨｬｨｪ06ｨｦ 020108. 020507 06ｨ 08ｨ ｨｰｨｪ06ｨｦ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨｨｨ ｨｨ09070605ｨｹ040609ｨ 05ｨｨ 0708ｨ ｨｦｨｬ020804, 0708020109ｨｰｨ 09050706ｨｴｨｨ02 0906ｨ 06ｨｦ 09ｨｬ0209ｨｹ 0605ｨｨ0006-dT ｨｨ 0905ｨｮ ﾂｨ ｨｦｨｪ0401 0002ｨｺ09ｨ ｨｬ02080609, ｨｨ 0108ｨｮ00ｨｨ02 0802ｨ 0002ｨｪｨｰ04 ｨｨ04 ｨｪｨ ｨ 0608ｨ iscriptcdna Synthesis Kit (Bio- Rad, 050108) 09 090606ｨｰ0902ｨｰ09ｨｰ09ｨｨｨｨ 09 070806ｨｰ06ｨｺ060506ｨｬ 00ｨｨ08ｨｬ04-070806ｨｨ04090601ｨｨｨｰ020507. 020507 07080609020102ｨｪｨｨ07 030004 ｨｨ09070605ｨｹ040609ｨ 05ｨｨ 0708ｨ ｨｦｨｬ020804 ｨｨ 0406ｨｪ0104, 08ｨ 0408ｨ ｨ 06ｨｰｨ ｨｪｨｪ0402 ｨｪｨ ｨｬｨｨ 08ｨ ｨｪ0202 (000605ｨｪｨｨ02ｨｺｨｨｨｦ ｨｨ 0108., 2012). 0402ｨ ｨｺ02ｨｨ06ｨｪｨｪｨ 07 09ｨｬ0209ｨｹ (50 ｨｬｨｺ05) 090601020803ｨ 05ｨ 0601ｨｪ06ｨｺ08ｨ ｨｰｨｪ04ｨｦ ｨ ｨｮ000208 010507 Taq-070605ｨｨｨｬ0208ｨ 0404 (ph 8.6), 1 ｨｬ00 01050608ｨｨ01 Mg, 2.5 0201. Taq-070605ｨｨｨｬ0208ｨ 0404 (05ｨｨ0502ｨｺ09, 04060909ｨｨ07), 250 ｨｬｨｺ00 ｨｺｨ 0301060006 dntp, 300 ｨｪ00 070807ｨｬ060006 ｨｨ 06ｨ 08ｨ ｨｰｨｪ060006 0708ｨ ｨｦｨｬ02080609, 250 ｨｪ00 0005ｨｮ060802090202ｨｪｨｰｨｪ06 ｨｬ02 ﾂ02ｨｪｨｪ060006 0406ｨｪ01ｨ (05ｨｨｨｪｨｰ0605, 04060909ｨｨ07) ｨｨ 2 ｨｬｨｺ05 ｨｺ020108. 0402ｨ ｨｺ02ｨｨ06 070806090601ｨｨ05ｨｨ ｨｪｨ 0102ｨｰ02ｨｺｨｰｨｨ08ｨｮ06ｨｴ02ｨｬ ｨ ｨｬ0705ｨｨ00ｨｨｨｺｨ ｨｰ060802 CFX96 (BioRad, 050108). 0202ｨｪｨ ｨｰｨｮ08ｨ 02ｨｨ06 0109ｨｮ01ｨｪｨｨｨｰ020906ｨｦ 020108 ｨｪｨ ｨｺｨ 030106ｨｬ ｨｨ04 45 02ｨｨｨｺ050609 0609ｨｮｨｴ0209ｨｰ09050705ｨｨ 0708ｨｨ 95 紊 09 ｨｰ02 ﾂ02ｨｪｨｨ02 15 09, ｨ 06ｨｰ03ｨｨ00 0708ｨ ｨｦｨｬ02080609 ｨｨ 0102ｨｰ02ｨｺｨｰｨｨ080609ｨ ｨｪｨｨ02 ｪ 0708ｨｨ 60 紊 09 ｨｰ02 ﾂ02ｨｪｨｨ02 1 ｨｬｨｨｨｪ. 0207080201020502ｨｪｨｨ02 070608060006090401 02ｨｨｨｺ050609 070806090601ｨｨ05ｨｨ 09 0706ｨｬ06ｨｴｨｹ06 0909ｨｰ080602ｨｪｨｪ06ｨｦ 09 0708ｨｨｨ 0608 0708060008ｨ ｨｬｨｬ04 CFXManager. 04ｨ 09 ﾂ02ｨｰ 06ｨｰｨｪ0609ｨｨｨｰ0205ｨｹｨｪ0401 ｨｮ080609ｨｪ02ｨｦ 070806ｨｨ04090601ｨｨ05ｨｨ 09 0706ｨｬ06ｨｴｨｹ06 000608ｨｬｨｮ0504R=2 cqref-cq, 000102 09q ｨｨ cqref ｪ 070608060006090402 02ｨｨｨｺ0504 010507 ｨｨ09ｨｺ06ｨｬ06ｨｦ ｨｨ 080200020802ｨｪ09ｨｪ06ｨｦ ｨｺ020108 0002ｨｪｨ GAPDH. 040204ｨｮ05ｨｹｨｰｨ ｨｰ04 0708020109ｨｰｨ 090502ｨｪ04 09 09ｨｨ0102 090606ｨｰｨｪ060302ｨｪｨｨ07 ｨｮ080609ｨｪ02ｨｦ ｨｨ0406000608ｨｬ-09070202ｨｨ00ｨｨ ﾂ0209ｨｺｨｨ01 ｨｬ040108 0002ｨｪｨ TP73 ｨｨ ｨｪ0608ｨｬｨｨ08060906 ﾂｨｪ060006 0002ｨｪｨ GAPDH. 05ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨ 07 06ｨ 08ｨ ｨ 06ｨｰｨｺｨ 080204ｨｮ05ｨｹｨｰｨ ｨｰ0609. 08ｨ 030104ｨｦ 05ｨｺ09070208ｨｨｨｬ02ｨｪｨｰ 070806090601ｨｨ05ｨｨ ｨｪ02 ｨｬ02ｨｪ0202 3 08ｨ 04 09 ｨｰ080201-
13262 01. 03. 08020106080609ｨ ｨｨ 0108. ｨｺ08ｨ ｨｰｨｪ04ｨｬｨｨ 070609ｨｰ0608ｨ ｨｬｨｨ. 03060109 ﾂ02ｨｰ 09080201ｨｪｨｨ01 04ｨｪｨ ﾂ02ｨｪｨｨｨｦ ｨｨ 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ0401 0603ｨｨｨ 06ｨｺ 070806090601ｨｨ05ｨｨ 09 ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨ02ｨｬ 07ｨ ｨｺ02ｨｰｨ STATISTICA 6.0. 020609ｨｰ06090208ｨｪ0609ｨｰｨｹ 08ｨ 0405ｨｨ ﾂｨｨｨｦ 060202ｨｪｨｨ09ｨ 05ｨｨ 0706 t-ｨｺ08ｨｨｨｰ0208ｨｨ06 05ｨｰｨｹ060102ｨｪｨｰｨ. 04ｨ 0405ｨｨ ﾂｨｨ07 09 ﾂｨｨｨｰｨ 05ｨｨ 010609ｨｰ06090208ｨｪ04ｨｬｨｨ 0708ｨｨ 04 < 0.05. 0609070605ｨｹ040609ｨ ｨｪｨｪ0402 0802ｨ ｨｺｨｰｨｨ0904. 05080201ｨ 02000300 09 10%-ｨｪ06ｨｦ 05ｨｬｨ 08ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨｰ020507 ﾂｨｹ02ｨｦ 090409060806ｨｰｨｺ06ｨｦ (060605), L-0005ｨｮｨｰｨ ｨｬｨｨｨｪ06ｨｬ ｨｨ 0002ｨｪｨｰｨ ｨｬｨｨ02ｨｨｨｪ06ｨｬ (03ｨ ｨｪ06ｨｺ06, 04060909ｨｨ07); 02020805 C 27 H 29 NO 11 (Sigma, 050108); 0002ｨｬｨ ｨｰ06ｨｺ09ｨｨ05ｨｨｨｪ 08ｨ 08ｨ ﾂ ﾂｨｨ (090608ｨｨ0900-08090600ｨ 010806, 04060909ｨｨ07); 09070202ｨｨ00ｨｨ ﾂ0209ｨｺｨｨ02 ｨ ｨｪｨｰｨｨｨｰ0205ｨ ab52293, ab4052, ab32539 ｨｨ ab58610 (Abcam, 000205ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨ07); ｨｺ0604ｨｹｨｨ ｨ ｨｪｨｰｨｨｨｺ080605ｨｨ ﾂｨｹｨｨ 070605ｨｨｨｺ0506ｨｪｨ 05ｨｹｨｪ0402 09ｨｰ06080402 ｨ ｨｪｨｰｨｨｨｰ0205ｨ, ｨｺ06ｨｪｨｲ0600ｨｨ080609ｨ ｨｪｨｪ0402 09 0005ｨｮ060806010806ｨｬ06ｨｬ 08060600, ｪ ab98502; DAPI (Sigma, 050108); ｨｬ0609ｨｨ0605 (Calbiochem, 050108); ｨｪｨ ｨ 0608 0802ｨ 0002ｨｪｨｰ0609 DeadEnd TM ColorimetricTUNEL- System (Promega, 050108); ｨｪｨ ｨ 0608 AurumTotalRNAMinikit 09 020108ｨ 0406ｨｦ I (BioRad, 050108); ｨｪｨ ｨ 0608 iscriptcdnasynthesis- Kit (BioRad, 050108); ｨ ｨｮ000208 010507 Taq-070605ｨｨｨｬ0208ｨ 0404, 01050608ｨｨ01 ｨｬｨ 00ｨｪｨｨ07, Taq-070605ｨｨｨｬ0208ｨ 04ｨ ｨｨ dntp (05ｨｨ0502ｨｺ09, 04060909ｨｨ07); 0708ｨ ｨｦｨｬ020804 ｨｨ 0005ｨｮ060802090202ｨｪｨｰｨｪ06 ｨｬ02 ﾂ02ｨｪｨｪ0402 0406ｨｪ0104 (05ｨｨｨｪｨｰ0605, 04060909ｨｨ07). 040204ｨｮ05ｨｹｨｰｨ ｨｰ04 00ｨｨｨｰ06ｨｰ06ｨｺ09ｨｨ ﾂ0209ｨｺ0602 0102ｨｦ09ｨｰ09ｨｨ02 02020805 ｨｪｨ 00ｨｨｨ 08 06 ｨ 05 ｨ 09 ｨｰ 04 ﾂ 02 05 06 09 02 ｨｺ ｨ. 03060109 ﾂ02ｨｰ ｨｺ0502ｨｰ06ｨｺ 080906 ﾁ ｨｪｨ 02ｨｨｨｰ06050600ｨｨ ﾂ0209ｨｺｨｨ01 07080207ｨ 08ｨ ｨｰｨ 01 0706ｨｺｨ 04ｨ 05, ﾂｨｰ06 ﾂ02080204 24 ﾂ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 ﾂｨｨ090506 ｨｺ0502ｨｰ06ｨｺ 09 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ (ｨｪ02ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ06ｨｦ ｨｨ ｨｪ02 06ｨ 08ｨ ｨ 06ｨｰｨ ｨｪｨｪ06ｨｦ 02020805) ｨｺｨｮ05ｨｹｨｰｨｮ0802 090609ｨｰｨ 0905070506 112 1 7 11 ｨｪｨ 07060502 040802ｨｪｨｨ07 ｨｬｨｨｨｺ080609ｨｺ0607ｨ. 00 ｨｬ06ｨｬ02ｨｪｨｰ 09ｨｪ020902ｨｪｨｨ07 02020805 09 ｨｺｨｮ05ｨｹｨｰｨｮ08ｨｮ ( ﾂ02080204 48 ﾂ 0706090502 ｨｪｨ ﾂｨ 05ｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07) ﾂｨｨ090506 ｨｺ0502ｨｰ06ｨｺ ｨｮ090205ｨｨ ﾂｨｨ050609ｨｹ ｨｨ 090609ｨｰｨ 09ｨｨ0506 164 1 7 18 ｨｪｨ 07060502 040802ｨｪｨｨ07. 05ｨ 09050201ｨｮ06ｨｴｨｨ02 24 ﾂ (72 ﾂ 0706090502 070609ｨ 01ｨｺｨｨ) 09 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ (ｨｪ02 06ｨ 08ｨ ｨ 06ｨｰｨ ｨｪｨｪ06ｨｦ 02020805) ｨｺｨｮ05ｨｹｨｰｨｮ0802 ﾂｨｨ090506 ｨｺ0502ｨｰ06ｨｺ ｨｮ090205ｨｨ ﾂｨｨ050609ｨｹ ｨｨ 010609ｨｰｨｨ000506 193 1 7 16 ｨｪｨ 07060502 040802ｨｪｨｨ07. 00 ｨｰ06 0302 090802ｨｬ07 09 ｨｺｨｮ05ｨｹｨｰｨｮ0802, 06ｨ 08ｨ ｨ 06ｨｰｨ ｨｪｨｪ06ｨｦ 02020805 09 ｨｰ02 ﾂ02ｨｪｨｨ02 24 ﾂ, 06ｨｰｨｬ02ｨｰｨｨ05ｨｨ 080204ｨｺ0602 09ｨｪｨｨ0302ｨｪｨｨ02 ﾂｨｨ0905ｨ 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ0609 0106 48 1 7 5 ｨｪｨ 07060502 040802ｨｪｨｨ07 (P <0.05) (08ｨｨ09. 1; 2, ｨ ). 06ｨｰ06 0604ｨｪｨ ﾂｨ 02ｨｰ, ﾂｨｰ06 06ｨ 08ｨ ｨ 06ｨｰｨｺｨ 080906 ﾁ ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺ06ｨｬ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 24 ﾂ 09 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ 5 ｨｬｨｺ00/ｨｬ05 0904040409ｨ 02ｨｰ 00ｨｨｨ 0205ｨｹ 06ｨｺ060506 70 % ｨｺ0502ｨｰ06ｨｺ, ｨｨ 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ02ｨｰ 06 09040906ｨｺ06ｨｦ ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｨ 02020805 09 06ｨｰｨｪ060302ｨｪｨｨｨｨ 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ0609 ﾂ0205060902ｨｺｨ. 030605ｨｮ ﾂ02ｨｪｨｪ0402 01ｨ ｨｪｨｪ0402 09010601ｨｪ04 09 080204ｨｮ05ｨｹｨｰｨ ｨｰｨ ｨｬｨｨ ｨ 09ｨｰ06080609, ｨｺ06ｨｰ06080402 0706ｨｺｨ 04ｨ 05ｨｨ 02ｨｨｨｰ06ｨｰ06ｨｺ09ｨｨ ﾂ0209ｨｺ0602 0102ｨｦ09ｨｰ09ｨｨ02 02020805 ｨｪｨ 01ｨｨ0000020802ｨｪ02ｨｨ080609ｨ ｨｪｨｪ0402 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ04 ﾂ0205060902ｨｺｨ (080603ｨｮ01ｨ 080609ｨ ｨｨ 0108., 2012). 04ｨｨ09. 1. 0005ｨｨ07ｨｪｨｨ02 02020805 ｨｪｨ 00ｨｨｨ 0205ｨｹ ｨｺ0502ｨｰ06ｨｺ 09 ｨｪ02ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ06ｨｦ (000000ｨC) ｨｨ ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ06ｨｦ 000000 (000000+) ｨｺｨｮ05ｨｹｨｰｨｮ08ｨ 01 080906 ﾁ. 080502ｨｰｨｺｨｨ 080906 ﾁ ﾂ02080204 24 ﾂ 0706090502 0706090209ｨ 04ｨ 08ｨ 03ｨ 05ｨｨ 000000. ﾁ02080204 24 ﾂ 0706090502 04ｨ 08ｨ 0302ｨｪｨｨ07 09ｨｪ0609ｨｨ05ｨｨ 02020805 ｨｨ ｨｨｨｪｨｺｨｮｨ ｨｨ080609ｨ 05ｨｨ 070609050201ｨｮ06ｨｴｨｨ02 24 ﾂ. 0202ｨｦ09ｨｰ09ｨｨ02 02020805 ｨｪｨ 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ04 ﾂ0205060902ｨｺｨ, ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0402 000000. 020507 060202ｨｪｨｺｨｨ 0102ｨｦ09ｨｰ09ｨｨ07 000000 ｨｺ0502ｨｰｨｺｨｨ 080906 ﾁ ﾂ02080204 24 ﾂ 0706090502 ｨｪｨ ﾂｨ 05ｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 04ｨ 08ｨ 03ｨ 05ｨｨ 09ｨｨ08ｨｮ0906ｨｬ ｨｨ 090401020803ｨｨ09ｨ 05ｨｨ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 09050201ｨｮ06ｨｴｨｨ01 24 ｨｨ 48 ﾂ (48 ｨｨ 72 ﾂ 0706090502 070609ｨ 01ｨｺｨｨ ｨｺ0502ｨｰ06ｨｺ 090606ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06). ﾁｨｨ090506 ｨｺ0502ｨｰ06ｨｺ 09 07080207ｨ 08ｨ ｨｰ02 09ｨｪｨｨ04ｨｨ050609ｨｹ 0706 0908ｨ 09ｨｪ02ｨｪｨｨ06 09 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ ｨｺｨｮ05ｨｹｨｰｨｮ0806ｨｦ ｨｨ 090609ｨｰｨ 09ｨｨ0506 99 1 7 10 ｨｨ 79 1 7 13 ｨｪｨ 07060502 040802ｨｪｨｨ07 (09 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ ｨｺｨｮ05ｨｹｨｰｨｮ0802 ｪ 164 1 7 18 ｨｨ 193 1 7 16 090606ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06) (08ｨｨ09. 1). 01ｨｨｨ 0205ｨｹ ｨｺ0502ｨｰ06ｨｺ 09 000000-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ06ｨｦ ｨｺｨｮ05ｨｹｨｰｨｮ0802 090609ｨｰｨ 09ｨｨ05ｨ 40 % ﾂ02080204 24 ﾂ ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｨ07 ｨｨ 59 % ﾂ02080204 48 ﾂ 0706 0908ｨ 09ｨｪ02ｨｪｨｨ06 09 ｨｪ0204ｨ 08ｨ 0302ｨｪｨｪ06ｨｦ ｨｺｨｮ05ｨｹｨｰｨｮ0806ｨｦ. 0308ｨｨ 09ｨｪ020902ｨｪｨｨｨｨ 02020805 09 000000-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪｨｮ06 ｨｺｨｮ05ｨｹｨｰｨｮ08ｨｮ 080906 ﾁ ﾂｨｨ090506 ｨｺ0502ｨｰ06ｨｺ ﾂ02080204 24 ﾂ 090609ｨｰｨ 09ｨｨ0506 70 1 7 15 ｨｪｨ 07060502 040802ｨｪｨｨ07, ﾂｨｰ06 0708ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺｨｨ ｨｪ02 06ｨｰ05ｨｨ ﾂｨ 050609ｨｹ 06ｨｰ ｨｺ0605ｨｨ ﾂ0209ｨｰ09ｨ ｨｺ0502ｨｰ06ｨｺ 09 000000-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ06ｨｦ ｨｺｨｮ05ｨｹｨｰｨｮ0802 ｨ 0204 06ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ 02020805 ｨｨ ｨ 040506 09 1.5 08ｨ 04ｨ ｨ 0605ｨｹ0302, ﾂ02ｨｬ 09 ｨｪ0204ｨ 08ｨ 0302ｨｪｨｪ06ｨｦ ｨｺｨｮ05ｨｹｨｰｨｮ0802 080906 ﾁ, ｪ 48 1 7 5 ｨｺ0502ｨｰ06ｨｺ ｨｪｨ 07060502 040802ｨｪｨｨ07 (04 < 0.05). 06ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 080906 ﾁ, ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0402 000000, 0708060102ｨｬ06ｨｪ09ｨｰ08ｨｨ080609ｨ 05ｨｨ ｨ 0605ｨｹ03ｨｮ06 ｨｮ09ｨｰ06ｨｦ ﾂｨｨ090609ｨｰｨｹ ｨｺ 02ｨｨｨｰ06ｨｰ06ｨｺ09ｨｨ ﾂ0209ｨｺ06ｨｬｨｮ 0102ｨｦ09ｨｰ09ｨｨ06 02020805, ﾂ02ｨｬ ｨｪ0204ｨ 08ｨ 0302ｨｪｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ. 000603ｨｪ06 04ｨ ｨｺ0506- ﾂｨｨｨｰｨｹ, ﾂｨｰ06 08ｨ 0409ｨｨｨｰｨｨ02 000000-ｨｨｨｪ0002ｨｺ02ｨｨｨｨ 09 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰｨ 01 060905ｨ ｨ 050702ｨｰ ｨｰ06ｨｺ09ｨｨ ﾂ0209ｨｺ0602 0102ｨｦ09ｨｰ09ｨｨ02 02020805 ｨｪｨ 070607ｨｮ050702ｨｨ06 ｨｺ0502ｨｰ06ｨｺ 080906 ﾁ. 0005ｨｨ07ｨｪｨｨ02 02020805 ｨｪｨ 07080605ｨｨ000208ｨ 02ｨｨ06 01ｨｨ070506ｨｨ01ｨｪ0401 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ0609 ﾂ0205060902ｨｺｨ. 020507 ｨｨ04ｨｮ ﾂ02ｨｪｨｨ07 0905ｨｨ07ｨｪｨｨ07 02020805 ｨｪｨ 07080605ｨｨ000208ｨ 02ｨｨ06 ｨｨ09070605ｨｹ040609ｨ 05ｨｨ ｨｬ06080006050600ｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｺ08ｨｨｨｰ0208ｨｨｨｦ ｪ ｨｨ0102ｨｪｨｰｨｨ00ｨｨｨｺｨ 02ｨｨ06 ｨｺ0502ｨｰ06ｨｺ, ｨｪｨ 01060107ｨｴｨｨ010907 09 ｨｬｨｨｨｰ060402, ｨｪｨ 02ｨｨｨｰ06050600ｨｨ ﾂ0209ｨｺ06ｨｬ 07080207ｨ 08ｨ ｨｰ02 ｨｨ 060202ｨｪｨｺｨｮ ｨｨ01 ｨｺ0605ｨｨ ﾂ0209ｨｰ09ｨ. 03060109 ﾂ02ｨｰ ｨｬｨｨｨｰ06ｨｰｨｨ ﾂ0209ｨｺｨｨ01 00ｨｨ00ｨｮ08 0706090502 06ｨｺ08ｨ 09ｨｺｨｨ 020108-090907040409ｨ 06ｨｴｨｨｨｬ ｨｺ08ｨ 09ｨｨｨｰ020502ｨｬ DAPI 0706ｨｺｨ 04ｨ 05, ﾂｨｰ06 09 ｨｬ06ｨｬ02ｨｪｨｰ 09ｨｪ020902ｨｪｨｨ07 ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺｨ 080906 ﾁ ｨｪｨ 010601ｨｨ05ｨｨ09ｨｹ 09 090609ｨｰ0607ｨｪｨｨｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ060006 01020502ｨｪｨｨ07 ｪ 01060507 ｨｺ0502ｨｰ06ｨｺ 09 00ｨ 0402 00 ｨｺ0502ｨｰ06 ﾂｨｪ060006 02ｨｨｨｺ05ｨ 090609ｨｰｨ 09ｨｨ05ｨ 15 1 7 3. ﾁ02080204 24 ﾂ 09 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ (ｨｪ02 06ｨ 08ｨ ｨ 06ｨｰｨ ｨｪｨｪ06ｨｦ ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺ06ｨｬ) ｨｺｨｮ05ｨｹｨｰｨｮ0802 01060507 ｨｬｨｨｨｰ06040609 ｨｮｨｬ02ｨｪｨｹ03ｨｨ05ｨ 09ｨｹ 0706 ﾂｨｰｨｨ 09 2 08ｨ 04ｨ, 090609ｨｰｨ 09ｨｨ09 8 1 7 2 (P < 0.05). 05ｨｪｨｨ0302ｨｪｨｨ02 010605ｨｨ ｨｬｨｨｨｰ06ｨｰｨｨ ﾂ0209ｨｺｨｨ01 ｨｺ0502ｨｰ06ｨｺ ｨｬ0603ｨｪ06 06ｨ ｨｲ0709ｨｪｨｨｨｰｨｹ ｨｰ02ｨｬ, ﾂｨｰ06 ﾂｨ 09ｨｰｨｹ ｨｺ0502ｨｰ06ｨｺ 0708060305ｨ 090902 00ｨ 0404 ｨｬｨｨｨｰ0604ｨ ｨｨ 08ｨ 04010205ｨｨ05ｨ 09ｨｹ, ｨ 0609ｨｰｨ 0903ｨｨ020907 ｨｺ0502ｨｰｨｺｨｨ 04ｨ ｨｬ020105ｨｨ05ｨｨ ｨｬｨｨｨｰ06ｨｰｨｨ ﾂ0209ｨｺ0602 01020502ｨｪｨｨ02 ｨｨ 0609ｨｰｨ ｨｪ0609ｨｨ05ｨｨ09ｨｹ 09 00ｨ 04ｨ 01, 07080201030209ｨｰ09ｨｮ06ｨｴｨｨ01 ｨｬｨｨｨｰ0604ｨｮ, 09 09090704ｨｨ 09 010609ｨｰｨｨ0302ｨｪｨｨ02ｨｬ ｨ 0605ｨｹ0302ｨｦ 070506ｨｰｨｪ0609ｨｰｨｨ ｨｬ06ｨｪ0609050607, ｨｰｨ ｨｺ ｨｺｨ ｨｺ 080906 ﾁ ｪ ｨｪ020607ｨｮ01060502090402 ｨｺ0502ｨｰｨｺｨｨ, 06ｨ 05ｨ 01ｨ 06ｨｴｨｨ02 090906ｨｦ09ｨｰ0906ｨｬ ｨｺ06ｨｪｨｰｨ ｨｺｨｰｨｪ060006 ｨｰ0608ｨｬ060302ｨｪｨｨ07 01020502ｨｪｨｨ07. 00 ｨｺｨｮ05ｨｹｨｰｨｮ0802, 06ｨ 08ｨ ｨ 06ｨｰｨ ｨｪｨｪ06ｨｦ 02020805, 01060507 ｨｬｨｨｨｰ06ｨｰｨｨ ﾂ0209ｨｺｨｨ01 00ｨｨ00ｨｮ08 09060108ｨ ｨｪ0705ｨ 09ｨｹ ｨｪｨ 09040906ｨｺ06ｨｬ ｨｮ080609ｨｪ02 (18 1 7 2 ). 030605ｨｮ ﾂ02ｨｪｨｪ0402 01ｨ ｨｪｨｪ0402 0706040906050706ｨｰ 070802010706050603ｨｨｨｰｨｹ, ﾂｨｰ06 02020805 ｨ 0506ｨｺｨｨ08ｨｮ02ｨｰ ｨｺ0502ｨｰｨｺｨｨ 09 ｨｬｨｨｨｰ060402, ｨｨ 05ｨｰ06, 0706-09ｨｨ01ｨｨｨｬ06ｨｬｨｮ, 0709050702ｨｰ0907 0601ｨｪｨｨｨｬ ｨｨ04 07080607090502ｨｪｨｨｨｦ 020006 02ｨｨｨｰ0609ｨｰｨ ｨｰｨｨ ﾂ0209ｨｺ060006 0102ｨｦ09ｨｰ09ｨｨ07. 00 08070102 08ｨ ｨ 06ｨｰ, 0904070605ｨｪ02ｨｪｨｪ0401 ｨｬ02ｨｰ060106ｨｬ 070806ｨｰ06 ﾂｨｪ06ｨｦ 02ｨｨｨｰ06ｨｬ02ｨｰ08ｨｨｨｨ 020108, 06ｨｰｨｬ02 ﾂｨ 05ｨｨ, ﾂｨｰ06 02020805 ｨ 0506ｨｺｨｨ08ｨｮ02ｨｰ ｨｺ0502ｨｰｨｺｨｨ 09 00ｨ 04ｨ 01 G 2 /M ｨｺ0502ｨｰ06 ﾂｨｪ060006 02ｨｨｨｺ05ｨ (Cruet-Hennequart et al., 2012; Fan et al., 2014). 06ｨ ｨｺ ｨｺｨ ｨｺ ｨｬ02ｨｰ0601 ｨｪ02 0706040906050702ｨｰ 08ｨ 0405ｨｨ ﾂｨｨｨｰｨｹ 00ｨ 0404 ｨｺ0502ｨｰ06 ﾂｨｪ060006 02ｨｨｨｺ05ｨ, 090606ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴｨｨ02 ｨｮ01090602ｨｪｨｪ06ｨｬｨｮ 090601020803ｨ ｨｪｨｨ06 020108 (4N), ｨ 09ｨｰ060804 090409ｨｺｨ 04ｨ 05ｨｨ 07080201070605060302ｨｪｨｨ02 06 ｨｰ06ｨｬ, ﾂｨｰ06 ﾂｨ 09ｨｰｨｹ 06ｨ 08ｨ ｨ 06ｨｰｨ ｨｪｨｪ0401 02020805 ｨｺ0502ｨｰ06ｨｺ ｨｬ060302ｨｰ 0609ｨｰｨ ｨｪｨ 0905ｨｨ09ｨ ｨｰｨｹ0907 ｨｪ02 09 00ｨ 04ｨ 01 G 2 /M, ｨ 07020802010601ｨｨｨｰｨｹ 09 00ｨ 04ｨｮ G 1 09 ｨｮ01090602ｨｪｨｪ04ｨｬ 090601020803ｨ ｨｪｨｨ02ｨｬ 020108 ｪ ｨｰｨ ｨｺ ｨｪｨ 040409ｨ 02ｨｬｨｮ06 00ｨ 04ｨｮ 4NG 1, ｨｪ02 070806ｨｦ0107 ｨｬｨｨｨｰ06ｨｰｨｨ ﾂ0209ｨｺ060006 01020502ｨｪｨｨ07 (Bielak-Zmijewska et al., 2014). 030605ｨｮ ﾂ02ｨｪｨｪ0402 ｨｪｨ ｨｬｨｨ 01ｨ ｨｪｨｪ0402 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ06ｨｰ 06 ｨｰ06ｨｬ, ﾂｨｰ06 09 ｨｮ09050609ｨｨ0701 ｨｪｨ 03ｨｨ01 060704ｨｰ0609 ｨ 0605ｨｹ03ｨ 07 ﾂｨ 09ｨｰｨｹ ｨｺ0502ｨｰ06ｨｺ 080906 ﾁ 070601 0102ｨｦ09ｨｰ09ｨｨ02ｨｬ 02020805 0609ｨｰｨ ｨｪｨ 0905ｨｨ09ｨ 02ｨｰ0907 09 ｨｬｨｨｨｰ060402 ｨｨ ｨｪ02 07020802010601ｨｨｨｰ 09 09ｨｰｨ 01ｨｨ06 G 1. 08ｨｪｨ 05ｨｨ04 ｨｬｨｨｨｰ06ｨｰｨｨ ﾂ0209ｨｺｨｨ01 00ｨｨ00ｨｮ08 09 ｨｺ0502ｨｰｨｺｨ 01 080906 ﾁ, ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 000000, 0706ｨｺｨ 04ｨ 05, ﾂｨｰ06 01060507 ｨｺ0502ｨｰ06ｨｺ, ｨｪｨ 01060107ｨｴｨｨ010907 09 ｨｬｨｨｨｰ060402, 090609ｨｰｨ 09ｨｨ05ｨ 5 1 7 1. 0306090502 0102ｨｦ09ｨｰ09ｨｨ07 02020805 ｨｪｨ ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ 05ｨｰ06ｨｰ 0706ｨｺｨ 04ｨ -
0005ｨｨ07ｨｪｨｨ02 ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺｨ 0106ｨｺ090608ｨｮｨ ｨｨ02ｨｨｨｪｨ ｨｪｨ 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ04 ﾂ0205060902ｨｺｨ, ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0402 02ｨｨｨｰ06ｨｬ0200ｨ 050609ｨｨ08ｨｮ0906ｨｬ 263 04ｨｨ09. 2. 0202ｨｦ09ｨｰ09ｨｨ02 02020805 (ｨ, 09) ｨｨ 000000 (01, 03) ｨｪｨ 080906 ﾁ in vitro. ｨ ｪ 02ｨｨｨｰ06ｨｰ06ｨｺ09ｨｨ ﾂ0209ｨｺ0602 0102ｨｦ09ｨｰ09ｨｨ02 02020805 ｨｪｨ 080906 ﾁ ﾂ02080204 24 ﾂ 0706090502 09ｨｪ020902ｨｪｨｨ07 ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺｨ 09 ｨｺｨｮ05ｨｹｨｰｨｮ08ｨｮ; ｨ ｪ ｨｺ06ｨｪｨｰ080605ｨｹ, 06ｨｺ08ｨ 03ｨｨ09ｨ ｨｪｨｨ02 0002ｨｬｨ ｨｰ06ｨｺ09ｨｨ05ｨｨｨｪ06ｨｬ 08ｨ 08ｨ ﾂ ﾂｨｨ; 09 ｪ 09ｨｨ04ｨｮｨ 05ｨｨ04ｨ 02ｨｨ07 0008ｨ 00ｨｬ02ｨｪｨｰｨｨ080609ｨ ｨｪｨｪ06ｨｦ 020108 ｨｬ02ｨｰ060106ｨｬ TUNEL 09 ｨｺ0502ｨｰｨｺｨ 01 ﾂ02080204 24 ﾂ 0706090502 06ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ 02020805; 00, ｨ ｨｰｨ ｨｺ0302 02, 04 ｪ ｨｰ02 0302 ｨｺ0502ｨｰｨｺｨｨ, 06ｨｺ08ｨ 0302ｨｪｨｪ0402 DAPI; 01 ｪ 0102ｨｰ02ｨｺ02ｨｨ07 09 0706ｨｬ06ｨｴｨｹ06 ｨ ｨｪｨｰｨｨｨｰ0205 ｨ ｨｺｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｪ06ｨｦ ｨｺｨ 0907ｨ 0404 3 09 ｨｺ0502ｨｰｨｺｨ 01 ﾂ02080204 48 ﾂ 0706090502 04ｨ 08ｨ 0302ｨｪｨｨ07 000000; 03 ｪ 0102ｨｰ02ｨｺ02ｨｨ07 ｨｬｨ 08ｨｺ0208ｨ ｨ ｨｮｨｰ0600ｨ 00ｨｨｨｨ LCP3A/B 09 0706ｨｬ06ｨｴｨｹ06 ｨ ｨｪｨｰｨｨｨｰ0205 09 ｨｺ0502ｨｰｨｺｨ 01 ﾂ02080204 48 ﾂ 0706090502 04ｨ 08ｨ 0302ｨｪｨｨ07 000000. ｨｰ0205ｨｹ ｨｪ02 ｨｨ04ｨｬ02ｨｪｨｨ050907 ｪ 6 ) 2. 06ｨｰ06 04ｨｪｨ ﾂ02ｨｪｨｨ02 09 3 08ｨ 04ｨ ｨｪｨｨ0302, ﾂ02ｨｬ 05ｨｰ06ｨｰ 0302 0706ｨｺｨ 04ｨ ｨｰ0205ｨｹ 010507 070607ｨｮ050702ｨｨｨｨ ｨｪ02ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 080906 ﾁ, 06ｨ 08ｨ ｨ 06ｨｰｨ ｨｪｨｪ0401 02020805 (18 ) 2 ). 030605ｨｮ ﾂ02ｨｪｨｪ0402 01ｨ ｨｪｨｪ0402 0706040906050706ｨｰ 04ｨ ｨｺ0506 ﾂｨｨｨｰｨｹ, ﾂｨｰ06 0708ｨｨ 0906040102ｨｦ09ｨｰ09ｨｨｨｨ 02020805 ｨｪｨ 000000-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0402 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ04 0708020106ｨｰ0908ｨ ｨｴｨ 02ｨｰ0907 ｨ 0506ｨｺ ｨｬｨｨｨｰ0604ｨ 09 06ｨｰ05ｨｨ ﾂｨｨ02 06ｨｰ 070607ｨｮ050702ｨｨｨｨ ｨｪ0204ｨ 08ｨ 0302ｨｪｨｪ0401 080906 ﾁ, 06ｨ 08ｨ ｨ 06ｨｰｨ ｨｪｨｪ0401 05ｨｰｨｨｨｬ ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺ06ｨｬ. 03 06 09 08 02 03 01 02 ｨｪ ｨｨ 02 02 01 08. 0201ｨｪｨｨｨｬ ｨｨ04 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ0609 070806ｨｰｨｨ09060607ｨｮ0106050209060006 0102ｨｦ09ｨｰ09ｨｨ07 02020805 0709050702ｨｰ0907 020006 0907060906ｨ ｨｪ0609ｨｰｨｹ 0904040409ｨ ｨｰｨｹ 0601ｨｨｨｪ06 ﾂｨｪ0402 ｨｨ 010906ｨｦｨｪ0402 08ｨ 0408040904 020108 (Burden, Osheroff, 1998; Tsang et al., 2003). 0308020109ｨｰｨ 0905070506 ｨｨｨｪｨｰ02080209 09040709ｨｪｨｨｨｰｨｹ 0905ｨｨ07ｨｪｨｨ02 02020805 ｨｪｨ 0202050609ｨｰｨｪ0609ｨｰｨｹ 020108 09 080906 ﾁ. 020507 05ｨｰ060006 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ0402 (ｨｪ0206ｨ 08ｨ ｨ 06ｨｰｨ ｨｪｨｪ0402) ｨｨ 060704ｨｰｨｪ0402 (06ｨ 08ｨ ｨ 06ｨｰｨ ｨｪｨｪ0402 02020805) ｨｺ0502ｨｰｨｺｨｨ ｨｨ04ｨｮ ﾂｨ 05ｨｨ 09 0706ｨｬ06ｨｴｨｹ06
13264 01. 03. 08020106080609ｨ ｨｨ 0108. 04ｨｨ09. 3. 0207080201020502ｨｪｨｨ02 ｨｺｨ 0907ｨ 04 9, 8 ｨｨ 3 09 000000-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 ｨｺ0502ｨｰｨｺｨ 01 ｨ 0204 06ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ 02020805 ｨｨ ﾂ02080204 24 ﾂ 0706090502 0906040102ｨｦ09ｨｰ09ｨｨ07 ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺｨ. ｨｬ02ｨｰ0601ｨ TUNEL, 0706040906050706ｨｴ020006 06ｨ ｨｪｨ 08ｨｮ03ｨｨｨｰｨｹ 08ｨ 0408040904 09 020108. 01ｨ 08ｨｨ09. 2, 09 0708020109ｨｰｨ 090502ｨｪ04 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 06ｨｺ08ｨ 03ｨｨ09ｨ ｨｪｨｨ07 080906 ﾁ ｨｬ02ｨｰ060106ｨｬ TUNEL. 03060109 ﾂ02ｨｰ TUNEL-0706050603ｨｨｨｰ0205ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ (080906 ﾁ 09 0008ｨ 00ｨｬ02ｨｪｨｰｨｨ080609ｨ ｨｪｨｪ06ｨｦ 020108) 0706ｨｺｨ 04ｨ 05, ﾂｨｰ06 09 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ ｨｺｨｮ05ｨｹｨｰｨｮ0802 01060507 ｨｺ0502ｨｰ06ｨｺ 09 0706090802030102ｨｪｨｪ06ｨｦ 020108 ｨ 0405ｨ ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｪ 0.5 1 7 0.3 %. 0306090502 0905ｨｨ07ｨｪｨｨ07 02020805 01060507 ｨｺ0502ｨｰ06ｨｺ 09 0008ｨ 00ｨｬ02ｨｪｨｰｨｨ080609ｨ ｨｪｨｪ06ｨｦ 020108 080204ｨｺ06 09060408060905ｨ, 010609ｨｰｨｨ00ｨｪｨｮ09 5.2 1 7 0.8 %, ﾂｨｰ06 09 10 08ｨ 04 070802090403ｨ 0506 05ｨｰ06ｨｰ 0706ｨｺｨ 04ｨ ｨｰ0205ｨｹ 09 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ ｨｺｨｮ05ｨｹｨｰｨｮ0802 (04 <0.05). 000603ｨｪ06 04ｨ ｨｺ0506 ﾂｨｨｨｰｨｹ, ﾂｨｰ06 0601ｨｪｨｨｨｬ ｨｨ04 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ0609, 0708ｨｨ09060107ｨｴｨｨ01 ｨｺ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｬｨｮ 02ｨｨｨｰ06ｨｰ06ｨｺ09ｨｨ ﾂ0209ｨｺ06ｨｬｨｮ 0102ｨｦ09ｨｰ09ｨｨ06 02020805 ｨｪｨ 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ04, 0709050702ｨｰ0907 ｨｨｨｪ01ｨｮｨｺ02ｨｨ07 08ｨ 040804090609 09 ｨｬ060502ｨｺｨｮ0502 020108. 03060106ｨ ｨｪ0602 0102ｨｦ09ｨｰ09ｨｨ02 06ｨｰｨｬ02 ﾂ02ｨｪ06 0708ｨｨ 0906040102ｨｦ09ｨｰ09ｨｨｨｨ 02020805 ｨｨ ｨｪｨ 0108ｨｮ00ｨｨ02 ｨｺ0502ｨｰｨｺｨｨ ｪ 09ｨｺ020502ｨｰｨｪ0401 ｨｬ040302 (Yu et al., 2014), 0702 ﾂ02ｨｪｨｨ (Wang et al., 2014) ｨｨ 0902080102ｨ (Lian et al., 2013). 0306090502 0906040102ｨｦ09ｨｰ09ｨｨ07 ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺｨ ｨｪｨ ｨｺ0502ｨｰｨｺｨｨ 080906 ﾁ, 04ｨ 08ｨ 0302ｨｪｨｪ0402 000000, 01060507 ｨｺ0502ｨｰ06ｨｺ 09 090407090502ｨｪｨｪ04ｨｬｨｨ 08ｨ 04080409ｨ ｨｬｨｨ 020108 ｨｮ090205ｨｨ ﾂｨｨ05ｨ 09ｨｹ 0706 0908ｨ 09ｨｪ02ｨｪｨｨ06 09 ｨｺ0502ｨｰｨｺｨ ｨｬｨｨ, ｨｪ02 06ｨ 08ｨ ｨ 06ｨｰｨ ｨｪｨｪ04ｨｬｨｨ 02020805, ｨｨ 090609ｨｰｨ 09ｨｨ05ｨ 3.2 1 7 0.7 070806ｨｰｨｨ09 0.8 1 7 0.3 % (P < 0.05). 0201ｨｪｨ ｨｺ06 09 ｨｪ02ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ06ｨｦ 070607ｨｮ050702ｨｨｨｨ 01060507 ｨｺ0502ｨｰ06ｨｺ 09 0706090802030102ｨｪｨｪ06ｨｦ 020108 0706090502 0906040102ｨｦ09ｨｰ09ｨｨ07 02020805 ｨｮ090205ｨｨ ﾂｨｨ05ｨ 09ｨｹ ｨ 06050202 ﾂ02ｨｬ 09 10 08ｨ 04, ｨｰ060001ｨ ｨｺｨ ｨｺ 09 ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ06ｨｦ 070607ｨｮ050702ｨｨｨｨ ｪ 09 4 08ｨ 04ｨ. 030605ｨｮ ﾂ02ｨｪｨｪ0402 01ｨ ｨｪｨｪ0402 0706ｨｺｨ 040409ｨ 06ｨｰ, ﾂｨｰ06 09 000000-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 ｨｺ0502ｨｰｨｺｨ 01 ｨｨｨｪ01ｨｮ02ｨｨ08ｨｮ06ｨｰ0907 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ04, 0708020707ｨｰ09ｨｰ09ｨｮ06ｨｴｨｨ02 08ｨ 0409ｨｨｨｰｨｨ06 070806020209090609, 0708ｨｨ09060107ｨｴｨｨ01 ｨｺ 08ｨ 04080409ｨ ｨｬ 020108 0708ｨｨ 0906040102ｨｦ09ｨｰ09ｨｨｨｨ 02020805. 000407090502ｨｪｨｨ02 ｨｬｨ 08ｨｺ02080609 ｨ 070607ｨｰ0604ｨ ｨｨ ｨ ｨｮｨｰ0600ｨ 00 ｨｨ ｨｨ. 0002ｨｰ060106ｨｬ ｨｨｨｬｨｬｨｮｨｪ060005ｨｮ060802090202ｨｪ02ｨｨｨｨ in situ ｨｪ02 ｨｮ01ｨ 050609ｨｹ 09040709ｨｨｨｰｨｹ 09 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ ｨｺｨｮ05ｨｹｨｰｨｮ0802 ｨｺ0502ｨｰ06ｨｺ, 090601020803ｨ ｨｴｨｨ01 ｨ ｨｺｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｪ0402 000608ｨｬ04 ｨｺｨ 0907ｨ 04 3, 8 ｨｨ 9,ｨｺ06ｨｰ06080402 0709050706ｨｰ0907 ｨｬｨ 08ｨｺ0208ｨ ｨｬｨｨ 0708060008ｨ ｨｬｨｬｨｨ08ｨｮ02ｨｬ06ｨｦ 00ｨｨｨ 0205ｨｨ ｨｺ0502ｨｰ06ｨｺ. 0306090502 06ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ 02020805 09 ｨｰ02 ﾂ02ｨｪｨｨ02 8 ﾂ 09 ｨｪ0204ｨ 08ｨ 0302ｨｪｨｪ0401 ｨｺ0502ｨｰｨｺｨ 01 ｨｺｨ 0907ｨ 04ｨｮ 3 09040709ｨｨ05ｨｨ 09 47 1 7 8 % ｨｺ0502ｨｰ06ｨｺ, ｨ ｨｺｨ 0907ｨ 04 8ｨｨ906ｨ ｨｪｨ 08ｨｮ0302ｨｪ06 ｨｪ02 ｨ 040506. ﾁ02080204 24 ﾂ 0706090502 06ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ 02020805 01060507 ｨｺ0502ｨｰ06ｨｺ, 090601020803ｨ ｨｴｨｨ01 ｨ ｨｺｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｪｨｮ06 ｨｺｨ 0907ｨ 04ｨｮ 3, ｨｮｨｬ02ｨｪｨｹ03ｨｨ05ｨ 09ｨｹ 0106 7 1 7 1 %. 00 ｨｰ06 0302 090802ｨｬ07 ｨｺ0502ｨｰ06ｨｺ, 090601020803ｨ ｨｴｨｨ01 ｨｺｨ 0907ｨ 0404 8 ｨｨ 9, 09 070607ｨｮ050702ｨｨｨｨ 06ｨ ｨｪｨ 08ｨｮ0302ｨｪ06 ｨｪ02 ｨ 040506. 02ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨ02 ｨｺｨ 0907ｨ 04 8 ｨｨ 9, ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｴｨｨ01 09 ｨｨｨｪｨｨ02ｨｨｨ 02ｨｨｨｨ ｨ 070607ｨｰ0604ｨ, ｨｬ0603ｨｪ06 06ｨ ｨｲ0709ｨｪｨｨｨｰｨｹ ｨｪ02010609ｨｰｨ ｨｰ06 ﾂｨｪ06ｨｦ ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ06 ｨｬ02ｨｰ0601ｨ 0102ｨｰ02ｨｺ02ｨｨｨｨ. 0102 ｨｨ09ｨｺ0506 ﾂ02ｨｪ06 ｨｰｨ ｨｺ0302, ﾂｨｰ06 ｨｺｨ 0907ｨ 04ｨ 8 ｨｪ02 ｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ02ｨｰ0907 09 ｨｺ0502ｨｰｨｺｨ 01 080906 ﾁ, 07060106ｨ ｨｪ06 ｨｰ06ｨｬｨｮ ｨｺｨ ｨｺ 05ｨｰ06 06ｨｰｨｬ02- ﾂ02ｨｪ06 0708ｨｨ ｨｨ04ｨｮ ﾂ02ｨｪｨｨｨｨ 09ｨｰ0806ｨｬｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ (S-type) 09 ｨｪ02ｨｦ0806ｨ 05ｨ 09ｨｰ06ｨｬ02 (Bian et al., 2004). 000407090502ｨｪｨｨ02 ｨ ｨｺｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｪ06ｨｦ 000608ｨｬ04 05000002ｨｺｨｰ0608ｨｪ06ｨｦ ｨｺｨ 0907ｨ 0404 3 (executioner) 09 0706050609ｨｨｨｪ02 ｨｺ0502ｨｰ06ｨｺ 080906 ﾁ ﾂ02080204 8 ﾂ 0706090502 06ｨ 08ｨ ｨ 06ｨｰｨｺｨｨ ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺ06ｨｬ ｨｮｨｺｨ 040409ｨ 02ｨｰ ｨｪｨ ｨｮ ﾂｨ 09ｨｰｨｨ02 ｨｺｨ 0907ｨ 040604ｨ 09ｨｨ09ｨｨｨｬ0401 070806020209090609 09 ｨｬｨ 0909060906ｨｦ 00ｨｨｨ 0205ｨｨ 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ0609 ﾂ0205060902ｨｺｨ ｨｺ 24 ﾂ 0706090502 0906040102ｨｦ09ｨｰ09ｨｨ07 02020805. 05ｨｪｨｨ0302ｨｪｨｨ02 010605ｨｨ ｨｺ0502ｨｰ06ｨｺ, 090601020803ｨ ｨｴｨｨ01 ｨｺｨ 0907ｨ 04ｨｮ 3, 0106 7 %, ｨｺ 05ｨｰ06ｨｬｨｮ 090806ｨｺｨｮ, 090604ｨｬ0603ｨｪ06, 09090704ｨ ｨｪ06 09 00ｨｨｨ 0205ｨｹ06 ｨｰ0201 ｨｺ0502ｨｰ06ｨｺ, 09 ｨｺ06ｨｰ06080401 ｨｺｨ 0907ｨ 04ｨ 3 ｨ ｨｺｨｰｨｨ09ｨｨ080609ｨ 05ｨ 09ｨｹ ｨｪｨ ｨ 06050202 08ｨ ｨｪｨｪｨｨ01 090806ｨｺｨ 01 (8 ﾂ 0906040102ｨｦ09ｨｰ09ｨｨ07 02020805). 0208ｨｮ00ｨｨｨｬ 06ｨ ｨｲ0709ｨｪ02ｨｪｨｨ02ｨｬ ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨ 06050202 07060401ｨｪ0707 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 ｨ 070607ｨｰ0604ｨ 09 0609ｨｰｨ 0903ｨｨ010907 ｨｺ0502ｨｰｨｺｨ 01 ｨｨ05ｨｨ ｨｬ02ｨｪｨｹ03ｨ 07 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ ｨｨ01 ｨｺ 0102ｨｦ09ｨｰ09ｨｨ06 ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺｨ. 00 000000-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0402 080906 ﾁ 02020805 0106ｨ ｨ 09050705ｨｨ ﾂ02080204 24 ﾂ 0706090502 04ｨ 08ｨ 0302ｨｪｨｨ07. 08 05ｨｰ06ｨｬｨｮ ｨｬ06ｨｬ02ｨｪｨｰｨｮ 09 04ｨ 08ｨ 0302ｨｪｨｪ0401 ｨｺ0502ｨｰｨｺｨ 01 09040709ｨｨ05ｨｨ ｨｺｨ 0907ｨ 0404 3, 8 ｨｨ 9. 02060507 0706050603ｨｨｨｰ0205ｨｹｨｪ06 06ｨｺ08ｨ 0302ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 090609ｨｰｨ 09050705ｨ 49 1 7 5, 44 1 7 3 ｨｨ 51 1 7 4 % 090606ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06. 00 ｨｰ02 ﾂ02ｨｪｨｨ02 09050201ｨｮ06ｨｴｨｨ01 24 ﾂ (48 ﾂ 0706090502 ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｨ07) 09 04ｨ 08ｨ 0302ｨｪｨｪ06ｨｦ 070607ｨｮ050702ｨｨｨｨ 080906 ﾁ, ｨｪ02 06ｨ 08ｨ ｨ 06ｨｰｨ ｨｪｨｪ0401 02020805, 01060507 0706050603ｨｨｨｰ0205ｨｹｨｪ06 06ｨｺ08ｨ 0302ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ｨｮ090205ｨｨ ﾂｨｨ05ｨ 09ｨｹ ｨｨ 010609ｨｰｨｨ0005ｨ 77 1 7 5, 60 1 7 4 ｨｨ 781 7 6 % 090606ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06 (08ｨｨ09. 2, 01; 3). 0306090502 0906040102ｨｦ09ｨｰ09ｨｨ07 02020805 09 ｨｰ02 ﾂ02ｨｪｨｨ02 24 ﾂ 09 ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ06ｨｦ 070607ｨｮ050702ｨｨｨｨ (48 ﾂ 0706090502 04ｨ 08ｨ 0302ｨｪｨｨ07) 01060507 ｨｺ0502ｨｰ06ｨｺ, 090601020803ｨ ｨｴｨｨ01 ｨｺｨ 0907ｨ 0404 8ｨｨ9,09ｨｪｨｨ04ｨｨ05ｨ 09ｨｹ 09 1.5 08ｨ 04ｨ, 090609ｨｰｨ 09ｨｨ09 29 1 7 5ｨｨ 35 1 7 3 % 090606ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06 (04 <0.05). 02060507 ｨｺ0502ｨｰ06ｨｺ, 06ｨｺ08ｨ 0302ｨｪｨｪ0401 ｨ ｨｪｨｰｨｨｨｰ0205ｨ ｨｬｨｨ ｨｺ ｨｺｨ 0907ｨ 0402 3, 090609ｨｰｨ 09ｨｨ05ｨ 58 1 7 4% ｨｨ ｨ 0405ｨ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06 ｨｬ02ｨｪｨｹ0302, ﾂ02ｨｬ 09 ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ06ｨｦ 070607ｨｮ050702ｨｨｨｨ ｨ 0204 0102ｨｦ09ｨｰ09ｨｨ07 02020805 ｪ 77 1 7 5%(04 < 0.05) (08ｨｨ09. 3). 000603ｨｪ06 ｨｺ06ｨｪ09ｨｰｨ ｨｰｨｨ080609ｨ ｨｰｨｹ, ﾂｨｰ06 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 ｨｺ0502ｨｰ06ｨｺ 09 ｨ ｨｺｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｪ04ｨｬｨｨ ｨｺｨ 0907ｨ 04ｨ ｨｬｨｨ 09 000000-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ06ｨｦ 070607ｨｮ050702ｨｨｨｨ 080906 ﾁ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06 ｨｮｨｬ02ｨｪｨｹ03ｨ 02ｨｰ0907 0708ｨｨ 0906040102ｨｦ09ｨｰ09ｨｨｨｨ ｨｪｨ 05ｨｰｨｨ ｨｺ0502ｨｰｨｺｨｨ 02020805. 030605ｨｮ ﾂ02ｨｪｨｪ0402 01ｨ ｨｪｨｪ0402 0706ｨｺｨ 040409ｨ 06ｨｰ, ﾂｨｰ06 ｨｨ 000000, ｨｨ 02020805 ｨｨｨｪ01ｨｮ02ｨｨ08ｨｮ06ｨｰ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ06 ｨｺｨ 0907ｨ 040604ｨ 09ｨｨ09ｨｨｨｬ060006 ｨ 070607ｨｰ0604ｨ. 00 ｨｰ06 0302 090802ｨｬ07 ｨｪ02 ｨｨ09ｨｺ0506 ﾂ02ｨｪ06, ﾂｨｰ06 01ｨｨｨｪｨ ｨｬｨｨｨｺｨ ｨ 070607ｨｰ0604ｨ 0708ｨｨ 05ｨｰｨｨ01 0906040102ｨｦ09ｨｰ09ｨｨ0701 08ｨ 0405ｨｨ ﾂｨ 02ｨｰ0907. 00 ｨｪｨ 09ｨｰ0607ｨｴ0202 090802ｨｬ07 0706ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 00ｨｨｨ 0205ｨｹ ｨｺ0502ｨｰ06ｨｺ ｨｬ060302ｨｰ 0609ｨｮｨｴ0209ｨｰ090507ｨｰｨｹ0907 09 ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨ02ｨｬ 08ｨ 04ｨｪ0401 ｨｬ060502ｨｺｨｮ050708ｨｪ0401 ｨｨ ｨｺ0502ｨｰ06 ﾂｨｪ0401 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ0609, 09080201ｨｨ ｨｺ06ｨｰ06080401 ｨｪｨ 080701ｨｮ 09 ｨ 070607ｨｰ060406ｨｬ 06ｨｰｨｬ02 ﾂ02ｨｪｨ ｨ ｨｮｨｰ0600ｨ 00ｨｨ07. 00 09090704ｨｨ 09 05ｨｰｨｨｨｬ 0708020109ｨｰｨ 090507050609ｨｹ ｨｨｨｪｨｰ02080209ｨｪ04ｨｬ 09040709ｨｪｨｨｨｰｨｹ 09ｨｺ05ｨ 01 070806020209090609 ｨ ｨｮｨｰ0600ｨ 00ｨｨｨｨ 09 00ｨｨｨ 0205ｨｹ ｨｺ0502ｨｰ06ｨｺ 080906 ﾁ 070601 0102ｨｦ09ｨｰ09ｨｨ02ｨｬ 02020805. 0207080201020502ｨｪｨｨ02 ｨｬｨ 08ｨｺ0208ｨ ｨ ｨｮｨｰ0600ｨ 00ｨｨｨｨ ｪ ｨ 0205ｨｺｨ LCP3A/B ｪ ｨｬ02ｨｰ060106ｨｬ ｨｨｨｬｨｬｨｮｨｪ0602ｨｨｨｰ0601ｨｨｨｬｨｨ ﾂ0209ｨｺ060006 ｨ ｨｪｨ 05ｨｨ04ｨ 0706ｨｺｨ 04ｨ 0506, ﾂｨｰ06 ｨｺｨ ｨｺ 09 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ0401 ｨｺ0502ｨｰｨｺｨ 01, ｨｰｨ ｨｺ ｨｨ 09 ｨｺ0502ｨｰｨｺｨ 01, 06ｨ 08ｨ ｨ 06ｨｰｨ ｨｪｨｪ0401 02020805, 01ｨ ｨｪｨｪ04ｨｦ ｨ 020506ｨｺ 0708ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺｨｨ ｨｪ02 06ｨ ｨｪｨ 08ｨｮ03ｨｨ09ｨ 050907. 00 ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 000000 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰｨ 01 ﾂ02080204 24 ﾂ 0706090502 04ｨ 08ｨ 0302ｨｪｨｨ07 01060507 ｨｺ0502ｨｰ06ｨｺ, 06ｨｺ08ｨ 0302ｨｪｨｪ0401 ｨ ｨｪｨｰｨｨｨｰ0205ｨ ｨｬｨｨ ｨｺ ｨ 0205ｨｺｨｮ
130005ｨｨ07ｨｪｨｨ02 ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺｨ 0106ｨｺ090608ｨｮｨ ｨｨ02ｨｨｨｪｨ ｨｪｨ 00ｨｨｨ 0806ｨ 05ｨ 09ｨｰ04 ﾂ0205060902ｨｺｨ, ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0402 02ｨｨｨｰ06ｨｬ0200ｨ 050609ｨｨ08ｨｮ0906ｨｬ 265 ｨｬ040302ｨ 01 ｨｬ040302ｨｦ 070601 0906040102ｨｦ09ｨｰ09ｨｨ02ｨｬ 02020805 (Yu et al., 2014). 0208ｨｮ00ｨｨ02 ｨ 09ｨｰ060804 ｨｪｨ ｨ 050601ｨ 05ｨｨ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 ｨｮ080609ｨｪ07 05ｨｺ090708020909ｨｨｨｨ ｨ 0205ｨｺ0609, ｨｨｨｪ01ｨｮ02ｨｨ08ｨｮ02ｨｬ0401 0708ｨｨ ｨ ｨｮｨｰ0600ｨ 00ｨｨｨｨ: 0708ｨｨ 0906040102ｨｦ09ｨｰ09ｨｨｨｨ 02020805 ｨｪｨ ｨｺ0502ｨｰｨｺｨｨ 0609ｨｰ020609ｨ 08ｨｺ06ｨｬ04 U2OSandSaos-2 (Zhao et al., 2014), 000207ｨ ｨｰ06ｨｬ04 Hep3B (Chen et al., 2014) ｨｨ ｨｪｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ0402 ｨｺ0502ｨｰｨｺｨｨ 08ｨ ｨｺｨ 07ｨｨ ﾂｨｪｨｨｨｺｨ (Fong et al., 2012). 04ｨ 090106030102ｨｪｨｨ07 01ｨ ｨｪｨｪ0401 ｨｬ0600ｨｮｨｰ ｨ 04ｨｰｨｹ 06ｨ ｨｲ0709ｨｪ02ｨｪ04 08ｨ 04ｨｪ04ｨｬｨｨ 07ｨｮｨｰ07ｨｬｨｨ 06ｨｰ0902ｨｰｨ ｨｺ0502ｨｰ06ｨｺ ｨｪｨ 0102ｨｦ09ｨｰ09ｨｨ02 02020805 in vitro ｨｨ in vivo, 08ｨ 04ｨｪ04ｨｬｨｨ ｨｺ0502ｨｰ06 ﾂｨｪ04ｨｬｨｨ ｨｬ0601020507ｨｬｨｨ ｨｨ 01ｨ 0302 08ｨ 04ｨｪ04ｨｬｨｨ 09ｨｨ01ｨ ｨｬｨｨ 070601060704ｨｰｨｪ0401 03ｨｨ0906ｨｰｨｪ0401 (Dirks-Naylor, 2013). ﾁｨｰ06 ｨｺｨ 09ｨ 02ｨｰ0907 0905ｨｨ07ｨｪｨｨ07 02020805 ｨｪｨ 000000-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0402 080906 ﾁ, ｨｰ06 ｨｬ0603ｨｪ06 070802010706050603ｨｨｨｰｨｹ, ﾂｨｰ06 09 ｨｮ09050609ｨｨ0701 ｨｪｨ 03ｨｨ01 060704ｨｰ0609 ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺ ｨｪ02 06ｨｺｨ 040409ｨ 02ｨｰ 0905ｨｨ07ｨｪｨｨ07 ｨｪｨ ｨ ｨｮｨｰ0600ｨ 00ｨｨ06 080906 ﾁ, 06ｨｰｨｬ02 ﾂ02ｨｪｨｪｨｮ06 09 ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ0902 04ｨ 08ｨ 0302ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ｨｪｨ 07060401ｨｪｨｨ01 09ｨｰｨ 01ｨｨ0701 ｨｨｨｪ0002ｨｺ02ｨｨｨｨ. 0604ｨｬ02ｨｪ02ｨｪｨｨ02 ｨｮ080609ｨｪ07 ｨｬ040108 010507 ｨｨ0406000608ｨｬ ｨ 0205ｨｺｨ 0873 09 ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 080906 ﾁ. 0609090502010609ｨ ｨｪｨｨ02 ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨｨｨ 0002ｨｪｨ 060473 ｨｬ02ｨｰ060106ｨｬ 0206-030004 0706ｨｺｨ 04ｨ 0506 0708ｨｨ09ｨｮｨｰ09ｨｰ09ｨｨ02 09 ｨｪ02ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ06ｨｦ ｨｺｨｮ05ｨｹｨｰｨｮ0802 080906 ﾁ ｨｬ040108 010507 070605ｨｪ0608ｨ 04ｨｬ0208ｨｪ06ｨｦ ｨｨ0406000608ｨｬ04 ｨ 0205ｨｺｨ 06080873. 0201ｨｪｨ ｨｺ06 ｨｮ080609ｨｪｨｨ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨｨｨ ｨ 0405ｨｨ ｨｪｨｨ04ｨｺｨｨｨｬｨｨ (10 ｨC4 ｪ10 ｨC5 06ｨｰ ｨｮ080609ｨｪ07 ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨｨｨ 080200020802ｨｪ09ｨｪ060006 0002ｨｪｨ ) ｨｨ ｨｺ060502ｨ ｨ ｨｪｨｨ07 09 01ｨｨｨｪｨ ｨｬｨｨｨｺ02 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07 09 ｨｰ02 ﾂ02ｨｪｨｨ02 48 ﾂ ｨ 0405ｨｨ 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ- ﾂ0209ｨｺｨｨ ｨｪ0204ｨｪｨ ﾂｨｨｨｬ04 (08ｨｨ09. 4, ｨ ). 07ｨｺ060806 ﾂ02ｨｪｨｪｨ 07 ｨｨ0406000608ｨｬｨ dn0873 090606ｨ ｨｴ02 ｨｪ02 060708020102050705ｨ 09ｨｹ. 00 000000-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ06ｨｦ ｨｺｨｮ05ｨｹｨｰｨｮ0802 080906 ﾁ ｨｮ0302 ﾂ02080204 8 ﾂ 0706090502 04ｨ 08ｨ 0302ｨｪｨｨ07 ｨｮ08060902ｨｪｨｹ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨｨｨ 070605ｨｪ0608ｨ 04ｨｬ0208ｨｪ06ｨｦ ｨｨ0406000608ｨｬ04 06080873 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ06 0706090403ｨ 050907 (08ｨｨ09. 4, ｨ ). 08 24 ﾂ 0706090502 04ｨ 08ｨ 0302ｨｪｨｨ07 ｨｮ08060902ｨｪｨｹ 06080873 070802090403ｨ 05 ｨｮ08060902ｨｪｨｹ 09 ｨｺ06ｨｪｨｰ08060502 09 15 ｪ20 08ｨ 04. 00040906ｨｺｨｨｨｦ ｨｮ08060902ｨｪｨｹ ｨｬ040108 010507 06080873 ｨｪｨ ｨ 050601ｨ 050907 ｨｨ ｨｪｨ 09050201ｨｮ06ｨｴｨｨ01 090806ｨｺｨ 01 09070506ｨｰｨｹ 0106 48 ﾂ 0706090502 ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｨ07. 010206ｨ 010601ｨｨｨｬ06 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ 070607090502ｨｪｨｨ02 ｨｨ0406000608ｨｬ04 dn0873 09 ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 080906 ﾁ, ｨｪ0209ｨｬ06ｨｰ0807 ｨｪｨ ｨｰ06 ﾂｨｰ06 ｨｮ08060902ｨｪｨｹ ｨｬ040108 010507 05ｨｰ06ｨｦ ｨｨ0406000608ｨｬ04 (ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨｨ ｨｨ08ｨｮ02ｨｬ06ｨｦ 0906 09ｨｰ0608060006 070806ｨｬ06ｨｰ0608ｨ, 08ｨ 09070605060302ｨｪｨｪ060006 09 ｨ 05ｨｹｨｰ0208ｨｪｨ ｨｰｨｨ09ｨｪ06ｨｬ ｨｰ0802ｨｰｨｹ02ｨｬ ｨｨｨｪｨｰ0806ｨｪ02) 06ｨｰｨｪ0609ｨｨｨｰ0205ｨｹｨｪ06 ｨｪ02ｨ 0605ｨｹ0306ｨｦ. 08ｨｺｨｰｨｨ09ｨ 02ｨｨ07 ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨｨｨ 0002ｨｪｨ 060473 ｨｨ 070607090502ｨｪｨｨ02 ｨｨ0406000608ｨｬ04 dn0873 09 000000 ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 ｨｪ0608ｨｬｨ 05ｨｹｨｪ0401 (ｨｪ020607ｨｮ01060502090401) 080906 ﾁ, ｨｪｨ 09ｨｺ0605ｨｹｨｺ06 ｨｪｨ ｨｬ ｨｨ04090209ｨｰｨｪ06, 0706ｨｺｨ 04ｨ ｨｪ04 ｨｪｨ ｨｬｨｨ 09070208090402. 04ｨｨ09. 4. 0604ｨｬ02ｨｪ02ｨｪｨｨ02 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪｨ TP73 09 ｨｺ0502ｨｰｨｺｨ 01 080906 ﾁ ｨｪｨ 08ｨ 04ｨｪ0401 09ｨｰｨ 01ｨｨ0701 000000-ｨｨｨｪ0002ｨｺ02ｨｨｨｨ. 0306 000608ｨｨ0406ｨｪｨｰｨ 05ｨｨ ｪ 090802ｨｬ07 ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07, ﾂ; 0706 090208ｨｰｨｨｨｺｨ 05ｨｨ ｪ 06ｨｰｨｪ060302ｨｪｨｨ02 ｨｮ080609ｨｪ02ｨｦ ｨｨ0406000608ｨｬ-09070202ｨｨ00ｨｨ ﾂ0209ｨｺｨｨ01 ｨｬ040108 0002ｨｪｨ TP73 ｨｨ 080200020802ｨｪ09ｨｪ060006 0002ｨｪｨ GAPDH. ｨ ｪ ｨｺ06ｨｪｨｰ080605ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ, 06ｨｰ09 ﾂ02ｨｰ 090802ｨｬ02ｨｪｨｨ ｨｪｨ ﾂｨｨｨｪｨ 05ｨｨ ﾂ02080204 24 ﾂ 0706090502 ｨｪｨ ﾂｨ 05ｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07; ｨ ｪｨｺ0502ｨｰｨｺｨｨ ｨｪｨ 08ｨ 04ｨｪ0401 09ｨｰｨ 01ｨｨ0701 0706090502 04ｨ 08ｨ 0302ｨｪｨｨ07 000000. LCP3A/B, ｨｪｨ 010601ｨｨ05ｨ 09ｨｹ ｨｪｨ ｨｮ080609ｨｪ02 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ 070607ｨｮ050702ｨｨｨｨ ｨｨ ｨｪ02 070802090403ｨ 05ｨ 0.2 1 7 0.1 %. 0201ｨｪｨ ｨｺ06 ﾂ02080204 48 ﾂ 0706090502 ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｨ07 ｨｬｨ 08ｨｺ0208 ｨ ｨｮｨｰ0600ｨ 00ｨｨｨｨ 09040709ｨｨ05ｨｨ ｨｮ0302 09 83 1 7 6% ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ (08ｨｨ09. 2, 03). 0202ｨｦ09ｨｰ09ｨｨ02 02020805 ｨｪｨ ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0402 080906 ﾁ ｨｪ02 ｨｨ04ｨｬ02ｨｪｨｨ0506 01060506 LCP3A/B-0706050603ｨｨｨｰ0205ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ. 06ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, ｨｬ0603ｨｪ06 070802010706050603ｨｨｨｰｨｹ, ﾂｨｰ06 09 00ｨｨｨ 0205ｨｨ 080906 ﾁ (ｨｪ02 ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 000000) 070601 0906040102ｨｦ09ｨｰ09ｨｨ02ｨｬ 02020805 09 ｨｮ09050609ｨｨ0701 ｨｪｨ 03ｨｨ01 060704ｨｰ0609 ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｰ 0708060202090904 ｨ 070607ｨｰ0604ｨ ｨｨ ｨｪ02 0906090502 ﾂ02ｨｪ04 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ04 ｨ ｨｮｨｰ0600ｨ 00ｨｨｨｨ 09 ｨｮ ﾂｨ 09ｨｰｨｨ02ｨｬ ｨ 0205ｨｺｨ LCP3A/B. 040204ｨｮ05ｨｹｨｰｨ ｨｰ04 0607ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪｨｪ0401 08ｨ ｨ 06ｨｰ 06ｨ ｨｮ ﾂｨ 09ｨｰｨｨｨｨ ｨ ｨｮｨｰ0600ｨ 00ｨｨｨｨ 09 06ｨｰ0902ｨｰ02 ｨｪｨ 02020805 070806ｨｰｨｨ09060802 ﾂｨｨ0904. 01ｨ 03ｨｨ 01ｨ ｨｪｨｪ0402 09060005ｨ 09ｨｮ06ｨｰ0907 09 080204ｨｮ05ｨｹｨｰｨ ｨｰｨ ｨｬｨｨ ｨ 09ｨｰ06080609, ｨｪ02 06ｨ ｨｪｨ 08ｨｮ03ｨｨ0903ｨｨ01 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ 09 05ｨｺ090708020909ｨｨｨｨ 0707ｨｰｨｨ ｨｨ04ｨｮ ﾂ02ｨｪｨｪ0401 ｨｨｨｬｨｨ ｨｬｨ 08ｨｺ02080609 ｨ ｨｮｨｰ0600ｨ 00ｨｨｨｨ 09 09ｨｺ020502ｨｰｨｪ0401 02ｨ 09ｨｮ030102ｨｪｨｨ02 05060906ｨｺｨｮ07ｨｪ0609ｨｰｨｹ 070605ｨｮ ﾂ02ｨｪｨｪ0401 01ｨ ｨｪｨｪ0401, 06ｨ 06ｨ ｨｴ02ｨｪｨｪ0401 09 ｨｰｨ ｨ 05ｨｨ0202, 0706ｨｺｨ 040409ｨ 02ｨｰ, ﾂｨｰ06 0708ｨｨ 0906 ﾂ02ｨｰｨ ｨｪｨｪ06ｨｬ 0102ｨｦ09ｨｰ09ｨｨｨｨ 02020805 ｨｨ 000000 ｨｮｨｬ02ｨｪｨｹ03ｨ 02ｨｰ0907 00ｨｨｨ 0205ｨｹ ｨｺ0502ｨｰ06ｨｺ 080906 ﾁ, 09ｨｪｨｨ03ｨ 02ｨｰ0907 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 ｨｺ0502ｨｰ06ｨｺ 09 0706090802030102ｨｪｨｪ06ｨｦ 020108 ｨｨ ｨｪ02 ｨｪｨ ｨ 050601ｨ 02ｨｰ0907 ｨ 0506ｨｺｨ ｨｬｨｨｨｰ0604ｨ 0706 0908ｨ 09ｨｪ02ｨｪｨｨ06 09 ｨｪ0204ｨ 08ｨ 0302ｨｪｨｪ04ｨｬｨｨ ｨｺ0502ｨｰｨｺｨ ｨｬｨｨ, 06ｨ 08ｨ ｨ 06ｨｰｨ ｨｪｨｪ04ｨｬｨｨ 02020805. 000603ｨｪ06 070802010706050603ｨｨｨｰｨｹ, ﾂｨｰ06 000000 ｨ ｨｰｨｰ02ｨｪｨｮｨｨ08ｨｮ02ｨｰ 07060908020301ｨ 06ｨｴ0202 0102ｨｦ09ｨｰ09ｨｨ02 02020805 ｨｪｨ ｨｪ0608ｨｬｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ. 02020805 06ｨｺｨ 040409ｨ 02ｨｰ 070806ｨｰｨｨ09060607ｨｮ01060502090602 0102ｨｦ09ｨｰ09ｨｨ02, 07060908020301ｨ 07 020108 08ｨ ｨｺ060906ｨｦ ｨｺ0502ｨｰｨｺｨｨ. 00 ｨｰ06 0302 090802ｨｬ07 0002ｨｪ06ｨｰ06ｨｺ09ｨｨ ﾂ0209ｨｺｨｨｨｦ 05000002ｨｺｨｰ 02020805 06ｨｺｨ 040409ｨ 02ｨｰ ｨｰｨ ｨｺ0302 ｨｪｨ 0108ｨｮ00ｨｨ02 ｨｺ0502ｨｰｨｺｨｨ 060800ｨ ｨｪｨｨ04ｨｬｨ, 09 ｨｰ06ｨｬ ﾂｨｨ090502 0902080102ｨ, 09 ｨｰｨｺｨ ｨｪｨｨ ｨｺ06ｨｰ0608060006 ｨｨ04ｨｬ02ｨｪ0702ｨｰ0907 05ｨｺ090708020909ｨｨ07 11 0002ｨｪ0609, ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｴｨｨ01 09 0706090802030102ｨｪｨｨｨｨ 020108 ｨｨ 080207ｨ 08ｨ 02ｨｨｨｨ (Manjanatha et al., 2014). 05ｨｪ07ｨｰｨｨ02 07060908020301ｨ 06ｨｴ020006 0102ｨｦ09ｨｰ09ｨｨ07 02020805 ｨｪｨ ｨｪ0608ｨｬｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ 060800ｨ ｨｪｨｨ04ｨｬｨ ｪ 09ｨ 03ｨｪｨ 07 04ｨ 01ｨ ﾂｨ, 08020302ｨｪｨｨ02 ｨｺ06ｨｰ060806ｨｦ 04ｨ 09ｨｨ09ｨｨｨｰ 06ｨｰ ｨｪｨ 0106030102ｨｪｨｨ07 00ｨ ｨｺｨｰ06080609, ｨｺ06ｨｰ06080402 070604090605ｨｨ05ｨｨ ｨ 04 0708020106ｨｰ0908ｨ ｨｰｨｨｨｰｨｹ 00ｨｨｨ 0205ｨｹ ｨｪ0608ｨｬｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ, 09060108ｨ ｨｪｨｨ09 070806ｨｰｨｨ09060607ｨｮ0106050209ｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨ ｨｪｨｰｨｨｨ ｨｨ06ｨｰｨｨｨｺｨ. 01ｨ 0708ｨ 090502ｨｪｨｨ02 0706ｨｨ09ｨｺｨ ｨｰｨ ｨｺｨｨ01 00ｨ ｨｺｨｰ06080609 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｪｨ ｨｦ0102ｨｪ06 0708ｨｨ ｨｨ04ｨｮ ﾂ02ｨｪｨｨｨｨ 000000-ｨｨｨｪ0002ｨｺ02ｨｨｨｨ ｨｨ 070806ｨｰｨｨ090609ｨｨ08ｨｮ09ｨｪ060006 06ｨｰ0902ｨｰｨ ｨｺ0502ｨｰｨｺｨｨ.
13266 01. 03. 08020106080609ｨ ｨｨ 0108. 0005ｨｨ07ｨｪｨｨ02 02020805 ｨｪｨ 080906 ﾁ, ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0402 ｨｨ ｨｪ02ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0402 000000 080502ｨｰｨｺｨｨ ｨ ﾁｨｨ090506 ｨｺ0502ｨｰ06ｨｺ 09 07060502 040802ｨｪｨｨ07 ﾁｨｨ090506 ｨｬｨｨｨｰ06040609, 02060507 TUNEL0706050603ｨｨｨｰ0205ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ, % 02060507 ｨｺ0502ｨｰ06ｨｺ (%), 090601020803ｨ ｨｴｨｨ01 ｨｺｨ 0907ｨ 04ｨｮ 3 ｨｺｨ 0907ｨ 04ｨｮ 8 ｨｺｨ 0907ｨ 04ｨｮ 9 LC3A/B 000000 ｨC 02020805 ｨC 000000 + 02020805 ｨC 000000 ｨC 02020805 + 000000 + 02020805 + 193 1 7 16 8 1 7 2 0.5 1 7 0.3 0 0 0 0.2 1 7 0.1 79 1 7 13 ｨ 5 1 7 1 0.8 1 7 0.3 77 1 7 5 ｨ 60 1 7 4 ｨ 78 1 7 6 ｨ 83 1 7 6 ｨ 48 1 7 5 ｨ 18 1 7 2 ｨ 5.2 1 7 0.8 ｨ 7 1 7 1 ｨ 0 0 0 70 1 7 15 ｨ 6 1 7 2 3.2 1 7 0.7 ｨ 58 1 7 4 ｨ 29 1 7 5 ｨ 35 1 7 3 ｨ 79 1 7 8 ｨ ｨ 080502ｨｰｨｺｨｨ 080906 ﾁ ﾂ02080204 24 ﾂ 0706090502 070609ｨ 01ｨｺｨｨ 04ｨ 08ｨ 03ｨ 05ｨｨ 000000. ﾁ02080204 24 0706090502 04ｨ 08ｨ 0302ｨｪｨｨ07 09ｨｪ0609ｨｨ05ｨｨ 02020805 ｨｨ ｨｨｨｪｨｺｨｮｨ ｨｨ080609ｨ 05ｨｨ 09050201ｨｮ06ｨｴｨｨ02 24 ﾂ. 0806ｨｪｨｰ080605ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ (000000ｨC02020805ｨC) ｨ ｨｪｨ 05ｨｨ04ｨｨ080609ｨ 05ｨｨ 09 ｨｺ06ｨｪ0202 060704ｨｰｨ ( ﾂ02080204 72 ﾂ 0706090502 070609ｨ 01ｨｺｨｨ). ｨ 05ｨｪｨ ﾂ02ｨｪｨｨ07, 06ｨｰ05ｨｨ ﾂｨ 06ｨｴｨｨ020907 06ｨｰ ｨｺ06ｨｪｨｰ080605ｨｹｨｪ0401 (000000ｨC02020805ｨC) 09 ｨｺｨ 030106ｨｬ 09ｨｰ0605ｨ 0202 (04 < 0.05, ｨｺ08ｨｨｨｰ0208ｨｨｨｦ 05ｨｰｨｹ060102ｨｪｨｰｨ ). 0604090209ｨｰｨｪ06, ﾂｨｰ06 ｨｪｨ 08ｨ ｨｪｨｪｨｨ01 09ｨｰｨ 01ｨｨ0701 ｨｨｨｪ0002ｨｺ02ｨｨｨｨ 000000 0907060906ｨ 02ｨｪ 0708020707ｨｰ09ｨｰ090609ｨ ｨｰｨｹ 08ｨ 0409ｨｨｨｰｨｨ06 ｨ 070607ｨｰ0604ｨ, 09060108ｨ ｨｪ0707 03ｨｨ04ｨｪ020907060906ｨ ｨｪ0609ｨｰｨｹ ｨｺ0502ｨｰ06ｨｺ 0106 06ｨｺ06ｨｪ ﾂｨ ｨｪｨｨ07 08020705ｨｨｨｺｨ ｨｰｨｨ09ｨｪ060006 02ｨｨｨｺ05ｨ 090906020006 0002ｨｪ06ｨｬｨ. 0306ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 080701 0002ｨｪ0609 000000 ｨｮ ﾂｨ 09ｨｰ09ｨｮ02ｨｰ 09 070806ｨｰｨｨ09060102ｨｦ09ｨｰ09ｨｨｨｨ ｨ 070607ｨｰ0604ｨｮ, 09 ｨｰ06ｨｬ ﾂｨｨ090502 UL36 (vica), ｨｺ06ｨｰ060804ｨｦ 070601ｨ 09050702ｨｰ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ06 070806ｨｺｨ 0907ｨ 0404 8; UL37 (vmia) ｪ ｨｬｨｨｨｰ060106ｨｪ0108ｨｨｨ 05ｨｹｨｪ04ｨｦ ｨｨｨｪ00ｨｨｨ ｨｨｨｰ0608 ｨ 070607ｨｰ0604ｨ, ｨｺ06ｨｰ060804ｨｦ 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｮ02ｨｰ 09 ｨ 0205ｨｺ06ｨｬ Bax ｨｨ 0708020106ｨｰ0908ｨ ｨｴｨ 02ｨｰ 070208ｨｬ02ｨ ｨ ｨｨ05ｨｨ04ｨ 02ｨｨ06 ｨｬｨｨｨｰ060106ｨｪ0108ｨｨｨ 05ｨｹｨｪ06ｨｦ ｨｬ02ｨｬｨ 08ｨ ｨｪ04 (Goldmacher, 2005). 00 ｨｺ0502ｨｰｨｺｨ 01, 04ｨ 08ｨ 0302ｨｪｨｪ0401 000000, ｨｪｨ 08ｨ ｨｪｨｪｨｨ01 09ｨｰｨ 01ｨｨ0701 ｨｪ02 070806ｨｨ09010601ｨｨｨｰ 08ｨ 040804090609 020108, 09040709050702ｨｬ0401 ｨｬ02ｨｰ060106ｨｬ TUNEL (Chiou et al., 2001; 08020106080609ｨ ｨｨ 0108., 2008), ｨ ｨｰｨ ｨｺ0302 06ｨ ｨｪｨ 08ｨｮ0302ｨｪ04 ｨ 0205ｨｺｨｨ, 09060108ｨ ｨｪ0706ｨｴｨｨ02 0202050609ｨｰｨｪ0609ｨｰｨｹ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 020108 0708ｨｨ 000000-ｨｨｨｪ0002ｨｺ02ｨｨｨｨ (Fortunato, Spector, 1998). 0207ｨｮｨ 05ｨｨｨｺ0609ｨ ｨｪ04 01ｨ ｨｪｨｪ0402 06 ｨｰ06ｨｬ, ﾂｨｰ06 070601 0102ｨｦ09ｨｰ09ｨｨ02ｨｬ 000000 0706090403ｨ 02ｨｰ0907 ｨｮ09ｨｰ06ｨｦ ﾂｨｨ090609ｨｰｨｹ ｨｺ0502ｨｰ06ｨｺ ｨｺ 08ｨ 0405ｨｨ ﾂｨｪ04ｨｬ 00ｨ ｨｺｨｰ0608ｨ ｨｬ, ｨｨｨｪ01ｨｮ02ｨｨ08ｨｮ06ｨｴｨｨｨｬ ｨ 070607ｨｰ0604, 09 ｨｰ06ｨｬ ﾂｨｨ090502 ｨｺ 02ｨｨｨｰ06ｨｰ06ｨｺ09ｨｨ- ﾂ0209ｨｺｨｨｨｬ 0902ｨｴ0209ｨｰ09ｨ ｨｬ, ｨｰｨ ｨｺｨｨｨｬ ｨｺｨ ｨｺ ｨ ｨｺｨｰｨｨｨｪ06ｨｬｨｨ02ｨｨｨｪ 02 ｨｨ 02ｨｨ090705ｨ ｨｰｨｨｨｪ (Cinatl et al., 1998; Terrasson et al., 2005). 00 070609050201ｨｪ0202 090802ｨｬ07 09ｨｪｨｨｨｬｨ ｨｪｨｨ02 ｨｨ09090502010609ｨ ｨｰ020502ｨｦ 0708ｨｨ090502ｨｺｨ 02ｨｰ ｨ 020506ｨｺ 0873, 0002ｨｪ ｨｺ06ｨｰ0608060006 ｨｨｨｬ0202ｨｰ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0602 0901060109ｨｰ0906 09 0706090502010609ｨ ｨｰ0205ｨｹｨｪ0609ｨｰ07ｨｬｨｨ 070806ｨｰ06ｨｰｨｨ07ｨｪ060006 0607ｨｮ0106050209060006 09ｨｮ07080209090608ｨ ｪ ｨ 0205ｨｺｨ 0853. 02ｨｰ05ｨｨ ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｦ 060906ｨ 02ｨｪｨｪ0609ｨｰｨｹ06 ｨ 0205ｨｺｨ 0873 0709050702ｨｰ0907 06ｨ 08ｨ 040609ｨ ｨｪｨｨ02 ｨ 0605ｨｹ03060006 ｨｺ0605ｨｨ ﾂ0209ｨｰ09ｨ C- ｨｨ N-ｨｺ06ｨｪ0202090401 ｨｨ0406000608ｨｬ ｨｺｨ ｨｺ 080204ｨｮ05ｨｹｨｰｨ ｨｰ ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨ07 ｨ 05ｨｹｨｰ0208ｨｪｨ ｨｰｨｨ09ｨｪ060006 090705ｨ ｨｦ09ｨｨｨｪ00ｨ ｨｨ ｨ 05ｨｹｨｰ0208ｨｪｨ ｨｰｨｨ09ｨｪ060006 070806ｨｬ06ｨｰ0608ｨ. 02 080605ｨｨ ｨｨ0406000608ｨｬ ｨ 0205ｨｺｨ 0873 0909020102ｨｪｨｨｨｦ ｨｪ02010609ｨｰｨ ｨｰ06 ﾂｨｪ06, ｨｪ06 01ｨ ｨｪｨｪ0402 06ｨ ｨ ｨｪｨｰｨ 0006ｨｪｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨｨ01 00ｨｮｨｪｨｺ02ｨｨ0701 ｨｪ02ｨｺ06ｨｰ06080401 ｨｨ0406000608ｨｬ 070604090605ｨｨ05ｨｨ ｨｨ09090502010609ｨ ｨｰ020507ｨｬ 070609ｨｰｨ 09ｨｨｨｰｨｹ 090607080609: ﾂ02ｨｬ 0302 0709050702ｨｰ0907 0873 ｪ 0607ｨｮ010605020904ｨｬ 09ｨｮ0708020909060806ｨｬ ｨｨ05ｨｨ 06ｨｪｨｺ060002ｨｪ06ｨｬ (Stiewe, Pｨｹtzer, 2002)? 00ｨ 0506 ｨｨ04090209ｨｰｨｪ06 ｨｨ 06ｨ ｨｮ ﾂｨ 09ｨｰｨｨｨｨ ｨｨ0406000608ｨｬ 0873 09 080200ｨｮ050702ｨｨｨｨ 07080605ｨｨ000208ｨ 02ｨｨｨｨ ｨｨ 00ｨｨｨ 0205ｨｨ ｨｪ0608ｨｬｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ, 09 ｨｰ06ｨｬ ﾂｨｨ090502 070601 0102ｨｦ09ｨｰ09ｨｨ02ｨｬ 02020805. 0004 ｨｨ04ｨｬ0208ｨｨ05ｨｨ ｨｮ080609ｨｪｨｨ ｨｬ040108 0109ｨｮ01 ｨｨ0406000608ｨｬ ｨ 0205ｨｺｨ 0873 ｪ 06080873 ｨｨ dnp73 ｪ 09 080906 ﾁ ｨｨ 070806ｨ ｨｪｨ 05ｨｨ04ｨｨ080609ｨ 05ｨｨ 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 07080607090502ｨｪｨｨ07 ｨｬｨ 08ｨｺ02080609 0708060008ｨ ｨｬｨｬｨｨ080609ｨ ｨｪｨｪ06ｨｦ 00ｨｨｨ 0205ｨｨ ｨｺ0502ｨｰ06ｨｺ ｪ ｨ ｨｺｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｪ0401 ｨｺｨ 0907ｨ 04. 030605ｨｮ ﾂ02ｨｪｨｪ0402 01ｨ ｨｪｨｪ0402 0706ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ06 ｨｮ08060902ｨｪｨｹ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨｨｨ ｨｨ0406000608ｨｬ04 06080873 09 ｨｪ02ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 080906 ﾁ 0106ｨｰ07 ｨｨ ｨｪｨｨ0406ｨｺ, ｨｪ06 010609ｨｰｨ ｨｰ06 ﾂ02ｨｪ 010507 ｨｨｨｪ01ｨｮｨｺ02ｨｨｨｨ ｨ 070607ｨｰ0604ｨ 070601 0102ｨｦ09ｨｰ09ｨｨ02ｨｬ 02020805. 0604090209ｨｰｨｪ06, ﾂｨｰ06 09 06ｨｰ0902ｨｰ ｨｪｨ 0706090802030102ｨｪｨｨ02 020108 ｨｰ08ｨ ｨｪ09ｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ06ｨｴｨ 07 00ｨｮｨｪｨｺ02ｨｨ07 ｨ 0205ｨｺｨ 0873 0706090403ｨ 02ｨｰ0907 09 0609ｨｪ0609ｨｪ06ｨｬ ｨｪ02 ﾂ02080204 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ06 ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨｨｨ 020006 0002ｨｪｨ, ｨ ｨｪｨ ｨ 0205ｨｺ060906ｨｬ ｨｮ080609ｨｪ02 09 0706ｨｬ06ｨｴｨｹ06 ｨｬｨｪ060006 ﾂｨｨ090502ｨｪｨｪ0401 070609ｨｰｨｰ08ｨ ｨｪ09050702ｨｨ06ｨｪｨｪ0401 ｨｬ0601ｨｨ00ｨｨｨｺｨ 02ｨｨｨｦ. 080806ｨｬ02 ｨｰ060006, 0706ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨｨ0406000608ｨｬｨ 06080873 ｨｪ0206ｨ 010601ｨｨｨｬｨ 010507 ｨｺ06ｨｪｨｰｨ ｨｺｨｰｨｪ060006 ｨｰ0608ｨｬ060302ｨｪｨｨ07 080609ｨｰｨ ｨｺ0502ｨｰ06ｨｺ (Beitzinger et al., 2008). 040605ｨｹ ｨ 0205ｨｺｨ 06080873 09 0708020106ｨｰ0908ｨ ｨｴ02ｨｪｨｨｨｨ ｨｺ06ｨｪｨｰｨ ｨｺｨｰｨｪ06-ｨｪ0204ｨ 09ｨｨ09ｨｨｨｬ06ｨｦ 07080605ｨｨ000208ｨ 02ｨｨｨｨ 09090704ｨ ｨｪｨ 09 020006 ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪ06ｨｦ 0708060008ｨ ｨｬｨｬ06ｨｦ (06ｨｰ05ｨｨ ﾂｨｪ06ｨｦ 06ｨｰ 0853), ｨ ｨｨｨｬ02ｨｪｨｪ06 09 ｨｪｨ 01060107ｨｴｨｨｨｬｨｨ0907 070601 020006 ｨｺ06ｨｪｨｰ08060502ｨｬ ｨｬ02ｨｬｨ 08ｨ ｨｪｨｪ04ｨｬｨｨ ｨ 0205ｨｺｨ ｨｬｨｨ FAM38B ｨｨ KCNK1. 02ｨｰｨｬ02 ﾂ02ｨｪｨｪ0602 ｨｪ0204ｨｪｨ - ﾂｨｨｨｰ0205ｨｹｨｪ0602 070609040302ｨｪｨｨ02 ｨｮ080609ｨｪ07 ｨｬ040108 010507 ｨｨ0406000608ｨｬ04 06080873 ｨｺ 48 ﾂ ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ 09090704ｨ ｨｪ06 09 ｨｮ0302 ｨｪｨ ﾂｨ 0903ｨｨｨｬ0907 ｨｰ0608ｨｬ060302ｨｪｨｨ02ｨｬ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 07080605ｨｨ000208ｨ 02ｨｨｨｨ (72 ﾂ 0706090502 ｨｪｨ ﾂｨ 05ｨ ｨｺｨｮ05ｨｹｨｰｨｨ09ｨｨ080609ｨ ｨｪｨｨ07). 0508ｨ 09ｨｪｨｨｨｰ0205ｨｹｨｪ04ｨｦ ｨ ｨｪｨ 05ｨｨ04 ｨｮ080609ｨｪ02ｨｦ ｨｬ040108 ｨｨ0406000608ｨｬ ｨ 0205ｨｺｨ 0873 0706ｨｺｨ 04ｨ 05, ﾂｨｰ06 09 080906 ﾁ, ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 000000, 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06 0706090403ｨ 02ｨｰ0907 ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ07 0002ｨｪｨ 060473, 0708ｨｨ ﾂ02ｨｬ 09 06ｨ 06ｨｨ01 070806ｨｬ06ｨｰ06080609. 0102 ｨｨ09ｨｺ0506 ﾂ02ｨｪ06, ﾂｨｰ06 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 ｨｮ080609ｨｪ07 ｨｬ040108 010507 ｨｨ0406000608ｨｬ04 06080873 09 05ｨｰ06ｨｦ 09ｨｨｨｰｨｮｨ 02ｨｨｨｨ 0709050702ｨｰ0907 07080607090502ｨｪｨｨ02ｨｬ 080200ｨｮ0507ｨｰ0608ｨｪ060006 ｨｬ0201ｨ ｨｪｨｨ04ｨｬｨ, 0708020106ｨｰ0908ｨ ｨｴｨ 06ｨｴ020006 070607090502ｨｪｨｨ02 ｨ ｨ 020808ｨ ｨｪｨｰｨｪ0401 ｨｬｨｨｨｰ06040609 ｨｨ ｨｪ0209ｨｰｨ ｨ ｨｨ05ｨｹｨｪ0609ｨｰｨｨ 0002ｨｪ06ｨｬｨ (Talos et al., 2007). 000604ｨｬ0603ｨｪ06, 09 05ｨｰｨｨｨｬ 09090704ｨ ｨｪ06 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨ02 ｨｪｨ ｨｺ06070502ｨｪｨｨ07 ｨｺ0502ｨｰ06ｨｺ 09 ｨｬｨｨｨｰ060402, ｨｪｨ ｨ 050601ｨ 090302020907 ｨｪｨ ｨｬｨｨ 0708ｨｨ 0102ｨｦ09ｨｰ09ｨｨｨｨ 02020805 ｨｪｨ 000000-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0402 080906 ﾁ. 030607090502ｨｪｨｨ02 ｨｮｨｺ060806 ﾂ02ｨｪｨｪ06ｨｦ ｨｨ0406000608ｨｬ04 dn0873 0708020109ｨｰｨ 09050702ｨｰ 060906ｨ 04ｨｦ ｨｨｨｪｨｰ02080209, ｨｰｨ ｨｺ ｨｺｨ ｨｺ 05ｨｰｨ ｨｨ0406000608ｨｬｨ, 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｮ07 09 06080873, ｨｨｨｪ00ｨｨｨ ｨｨ08ｨｮ02ｨｰ 0202 ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ, ﾂｨｰ06 09 09090606 06 ﾂ02080201ｨｹ ｨｨｨｪ00ｨｨｨ ｨｨ08ｨｮ02ｨｰ ｨｨｨｪ01ｨｮ02ｨｨ080609ｨ ｨｪｨｪ04ｨｦ ｨ 070607ｨｰ0604. 00ｨｰ060806ｨｦ ｨｬ0201ｨ ｨｪｨｨ04ｨｬ, 09 0706ｨｬ06ｨｴｨｹ06 ｨｺ06ｨｰ0608060006 05ｨｰｨ ｨｮｨｺ060806 ﾂ02ｨｪｨｪｨ 07 ｨｨ0406000608ｨｬｨ ｨ 0205ｨｺｨ 0873 ｨｬ060302ｨｰ ｨｮ090205ｨｨ ﾂｨｨ09ｨ ｨｰｨｹ ｨｮ09ｨｰ06ｨｦ ﾂｨｨ090609ｨｰｨｹ ｨｺ0502ｨｰ06ｨｺ ｨｺ 02020805, ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ 09090704ｨ ｨｪ 09 ｨｪ0201ｨ 09ｨｪ06 06ｨｰｨｺ0804ｨｰ06ｨｦ ｨｪ060906ｨｦ 00ｨｮｨｪｨｺ02ｨｨ02ｨｦ ｨ 0205ｨｺｨ dn0873 (Wilhelm et al., 2010). 0306ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 dn0873 0506ｨｺｨ 05ｨｨ04ｨｮ02ｨｰ0907 ｨｪ0207060908020109ｨｰ0902ｨｪｨｪ06 ｨｪｨ 09ｨ ｨｦｨｰ02 0706090802030102ｨｪｨｨ07 020108, 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｮ02ｨｰ 09 0902ｨｪ090608ｨｪ04ｨｬ ｨ 0205ｨｺ06ｨｬ 5300041 ｨｨ ｨｨｨｪ00ｨｨｨ ｨｨ08ｨｮ02ｨｰ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ06 080600 ｨｨ 070609050201ｨｮ06ｨｴ0202 000609000608ｨｨ05ｨｨ080609ｨ ｨｪｨｨ02 0853, ｨｰｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ 0905ｨｨ0707 ｨｨ ｨｪｨ 0853-04ｨ 09ｨｨ09ｨｨｨｬ04ｨｦ ｨ 070607ｨｰ0604. 01ｨ ｨ 050601ｨ 02ｨｬｨ 07 ｨｪｨ ｨｬｨｨ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 ｨｺｨ 0907ｨ 04 09 ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ0902 000000-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 090607080609060301ｨ 05ｨ 09ｨｹ 00ｨｨｨ 0205ｨｹ06 ｨｺ0502ｨｰ06ｨｺ, 0601ｨｪｨ ｨｺ06 ｨｪ02 09ｨｰ0605ｨｹ ｨｬｨ 0909060906ｨｦ, ｨｺｨ ｨｺ 0708ｨｨ 0102ｨｦ09ｨｰ09ｨｨｨｨ 02020805 (09ｨｬ. ｨｰｨ ｨ 05ｨｨ02ｨｮ). 000603ｨｪ06 070802010706050603ｨｨｨｰｨｹ, ﾂｨｰ06 09 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ 00ｨｨｨ 0205ｨｨ 080906 ﾁ 09ｨｺ0506 ﾂｨ 02ｨｰ0907 ｨｨｨｪ01ｨｮｨｺ02ｨｨ07 05ｨｺ090708020909ｨｨｨｨ ｨｨ0406000608ｨｬ04 dn0873. 030607090502ｨｪｨｨ02 ｨｮｨｺ060806- ﾂ02ｨｪｨｪ06ｨｦ ｨｨ0406000608ｨｬ04 09060401ｨ 02ｨｰ ｨｮ09050609ｨｨ07 010507 ｨ ｨｰｨｰ02ｨｪｨｮｨ 02ｨｨｨｨ 0905ｨｨ07ｨｪｨｨ07 02020805 ｨｪｨ 0706090802030102ｨｪｨｨ02 020108 ｨｨ 00ｨｨｨ 0205ｨｹ ｨｺ0502ｨｰ06ｨｺ. 0604ｨｮ ﾂ02ｨｪｨｪｨ 07 ｨｺ0502ｨｰ06 ﾂｨｪｨ 07 09ｨｨ09ｨｰ02ｨｬｨ 06ｨｰｨｺ080409ｨ 02ｨｰ 070208090702ｨｺｨｰｨｨ09ｨｮ 0706ｨｨ09ｨｺｨ 00ｨ ｨｺｨｰ06080609, 09ｨｪｨｨ03ｨ 06ｨｴｨｨ01 ｨｰ06ｨｺ09ｨｨ ﾂ0209ｨｺ0602 0102ｨｦ09ｨｰ09ｨｨ02 02020805 ｨｪｨ ｨｪ0608ｨｬｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ 060800ｨ ｨｪｨｨ04ｨｬｨ.