132014 000606020902010608 0606ｨｬ 56, 0111 05060101080905010403 05060506030004 0002050108, 040301070906040703000403 060105070906010200, 060804-1 06 0903030606010200, 00 0705090200060809 0304030202060809030608 06 050809080401020102 02060809030608 2-0102 06060308 08 08. 02. 0107ｨ ｨｺ0609 06ｨｪ09ｨｰｨｨｨｰｨｮｨｰ 050906050602ｨｨ06ｨｪｨｪ06ｨｦ 00ｨｨ04ｨｨ06050600ｨｨｨｨ ｨｨ ｨ ｨｨ0601ｨｨｨｬｨｨｨｨ ｨｨｨｬ. 06. 00. 0502 ﾂ02ｨｪ0609ｨ 040801, 05ｨ ｨｪｨｺｨｰ-0302ｨｰ0208ｨ ｨｮ0800, e-mail: alex_shpakov@list.ru 08. 02. 0107ｨ ｨｺ0609 05ｨｨ00ｨｪｨ 05ｨｹｨｪ0402 09ｨｨ09ｨｰ02ｨｬ04 ｨｬ060400ｨ, 080200ｨｮ05ｨｨ08ｨｮ02ｨｬ0402 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ, 060804-1 ｨｨ 050207ｨｰｨｨｨｪ06ｨｬ 0201ｨｪｨｨｨｬ ｨｨ04 09ｨ 03ｨｪ02ｨｦ03ｨｨ01 00ｨ ｨｺｨｰ06080609, 090201ｨｮｨｴｨｨ01 ｨｺ 08ｨ 0409ｨｨｨｰｨｨ06 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 09ｨ 01ｨ 08ｨｪ060006 01ｨｨｨ ｨ 02ｨｰｨ 2-0006 ｨｰｨｨ07ｨ (05022), 0709050706ｨｰ0907 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 09 000608ｨｬ06ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ09ｨｰ02ｨｬｨ 01 ｨｬ060400ｨ, 080200ｨｮ05ｨｨ08ｨｮ02ｨｬ0401 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ, ｨｨｨｪ09ｨｮ05ｨｨｨｪ0607060106ｨ ｨｪ04ｨｬ 00ｨ ｨｺｨｰ060806ｨｬ 080609ｨｰｨ -1 (060804-1) ｨｨ 050207ｨｰｨｨｨｪ06ｨｬ. 0308ｨｨ ﾂｨｨｨｪｨ ｨｬｨｨ 05ｨｰｨｨ01 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ 0709050706ｨｰ0907 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪ06-09060909ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ060006 ｨ ｨ 05ｨ ｨｪ09ｨ ｨｨ 05ｨｨ07ｨｨ01ｨｪ060006 06ｨ ｨｬ02ｨｪｨ, 090201ｨｮｨｴｨｨ02 ｨｺ 05ｨｨ0706ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｨ ｨｨ 09ｨｰ08020909ｨｮ 05ｨｪ01060705ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ060006 0802ｨｰｨｨｨｺｨｮ05ｨｮｨｬｨ 09 ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰｨｺｨ 01, ｨ ｨｰｨ ｨｺ0302 01ｨｨ0900ｨｮｨｪｨｺ02ｨｨｨｨ 09 ｨｪ02ｨｦ0806ｨｬ0201ｨｨｨ ｨｰ0608ｨｪ0401 09ｨｨ09ｨｰ02ｨｬｨ 01 ｨｬ060400ｨ, 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06 09090704ｨ ｨｪｨｪ0401 09 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ, 060804-1 ｨｨ 050207ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ04ｨｬｨｨ 09ｨｨ09ｨｰ02ｨｬｨ ｨｬｨｨ. 060102ｨｪｨｰｨｨ00ｨｨｨｺｨ 02ｨｨ07 ｨｬ060502ｨｺｨｮ050708ｨｪ0401 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ 09 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ, 060804-1 ｨｨ 050207ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ09ｨｰ02ｨｬｨ 01 ｨｬ060400ｨ 09 ｨｮ09050609ｨｨ0701 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｨ09070605ｨｹ040609ｨ ｨｪｨ 010507 08ｨ ｨｪｨｪ02ｨｦ 01ｨｨｨ 00ｨｪ0609ｨｰｨｨｨｺｨｨ 05ｨｰｨｨ01 04ｨ ｨ 06050209ｨ ｨｪｨｨｨｦ, ｨ ｨｰｨ ｨｺ0302 010507 08ｨ 0408ｨ ｨ 06ｨｰｨｺｨｨ ｨｪ06090401 09ｨｰ08ｨ ｨｰ0200ｨｨｨｦ 010507 0708020902ｨｪｨｰｨｨ09ｨｪ060006 0502 ﾂ02ｨｪｨｨ07 05022 ｨｪｨ 09ｨｰｨ 01ｨｨｨｨ 0708020101ｨｨｨ ｨ 02ｨｰｨ. 00 06ｨ 04060802 070806ｨ ｨｪｨ 05ｨｨ04ｨｨ080609ｨ ｨｪ04 01ｨ ｨｪｨｪ0402 05ｨｨｨｰ0208ｨ ｨｰｨｮ0804 ｨｨ 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 0906ｨ 09ｨｰ0902ｨｪｨｪ0401 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ, ｨｺｨ 09ｨ 06ｨｴｨｨ020907 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ 09 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ, 060804-1 ｨｨ 050207ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ09ｨｰ02ｨｬｨ 01 ｨｬ060400ｨ 09 ｨｮ09050609ｨｨ0701 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022 ｨｨ ｨｨ01 080605ｨｨ 09 05ｨｰｨｨ06050600ｨｨｨｨ ｨｨ 07ｨ ｨｰ060002ｨｪ020402 05022, ｨ ｨｰｨ ｨｺ0302 06ｨ 09ｨｮ0301ｨ 06ｨｰ0907 07060101060104, ｨｪｨ 0708ｨ 090502ｨｪｨｪ0402 ｨｪｨ 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨ02 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 05ｨｰｨｨ01 09ｨｨ09ｨｰ02ｨｬ. 080506 ﾂ02090402 09050609ｨ : 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ09, ｨｨｨｪ09ｨｮ05ｨｨｨｪ, ｨｨｨｪ09ｨｮ05ｨｨｨｪ0607060106ｨ ｨｪ04ｨｦ 00ｨ ｨｺｨｰ0608 080609ｨｰｨ -1, 050207ｨｰｨｨｨｪ, ｨｬ060400, 0802020207ｨｰ0608 ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ, 09ｨ 01ｨ 08ｨｪ04ｨｦ 01ｨｨｨ ｨ 02ｨｰ. 0308ｨｨｨｪ07ｨｰ0402 0906ｨｺ08ｨ ｨｴ02ｨｪｨｨ07: 0604 ｪ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060904ｨｦ 0802020207ｨｰ0608, 060804-1 ｪ ｨｨｨｪ09ｨｮ05ｨｨｨｪ0607060106ｨ ｨｪ04ｨｦ 00ｨ ｨｺｨｰ0608 080609ｨｰｨ -1, 060804104 ｪ 0802020207ｨｰ0608 ｨｨｨｪ09ｨｮ05ｨｨｨｪ0607060106ｨ ｨｪ060006 00ｨ ｨｺｨｰ0608ｨ 080609ｨｰｨ -1, 0608040509 ｪ 060804-090907040409ｨ 06ｨｴｨｨｨｦ ｨ 020506ｨｺ, 000501 ｪ ｨｬ0205ｨ ｨｪ0602ｨｨｨｰ09ｨｰｨｨｨｬｨｮ05ｨｨ08ｨｮ06ｨｴｨｨｨｦ 000608ｨｬ06ｨｪ, 05022 ｪ 09ｨ 01ｨ 08ｨｪ04ｨｦ 01ｨｨｨ ｨ 02ｨｰ 2-0006 ｨｰｨｨ07ｨ, 050604 ｪ 09ｨｰ08020909 05ｨｪ01060705ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ060006 0802ｨｰｨｨｨｺｨｮ05ｨｮｨｬｨ, IRS1 ｨｨ IRS2 ｪ ｨｨｨｪ09ｨｮ05ｨｨｨｪ-0802020207ｨｰ0608ｨｪ0402 09ｨｮｨ 09ｨｰ08ｨ ｨｰ04 1-0006 ｨｨ 2-0006 ｨｰｨｨ070609, PI3K ｪ 00060900ｨ ｨｰｨｨ01ｨｨ05ｨｨｨｪ0604ｨｨｨｰ0605-3-ｨｺｨｨｨｪｨ 04ｨ. 00 ｨｪｨ 09ｨｰ0607ｨｴ0202 090802ｨｬ07 09 ｨｬｨｨ0802 ｨｪ02 ｨｬ02ｨｪ0202 30 ｪ40 % ｨｪｨ 09020502ｨｪｨｨ07 ｨｨｨｬ0206ｨｰ ｨｨ04ｨ 04ｨｰ06 ﾂｨｪｨｮ06 ｨｬｨ 0909ｨｮ ｨｰ0205ｨ ｨｨ 0108ｨｮ00ｨｨ02 ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ02 08ｨ 0909ｨｰ0806ｨｦ09ｨｰ09ｨ. 0308ｨｨ 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨｨｨ ｨ 0102ｨｺ09ｨ ｨｰｨｪ06ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ 06ｨｪｨｨ 09ｨｪｨ ﾂｨ 05ｨ 0702080201060107ｨｰ 09 09ｨｰｨ 01ｨｨ06 0708020101ｨｨｨ ｨ 02ｨｰｨ, 010507 ｨｺ06ｨｰ0608060006 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ06 09ｨｪｨｨ0302ｨｪｨｨ02 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨｰｨｺｨ ｨｪ02ｨｦ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ, ｨｨ 01ｨ 050202, 0708ｨｨ ｨｪ02ｨ 05ｨ 00060708ｨｨ07ｨｰｨｪ06ｨｬ 090202ｨｪｨ 08ｨｨｨｨ, 09 0709ｨｪ04ｨｦ 09ｨ 01ｨ 08ｨｪ04ｨｦ 01ｨｨｨ ｨ 02ｨｰ 2-0006 ｨｰｨｨ07ｨ (05022), ｨｺ06ｨｰ060804ｨｦ 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ04ｨｮ02ｨｰ0907 03ｨｨ0806ｨｺｨｨｨｬ 090702ｨｺｨｰ0806ｨｬ 0609050603ｨｪ02ｨｪｨｨｨｦ 0906 09ｨｰ060806ｨｪ04 0902080102 ﾂｨｪ06-090609ｨｮ01ｨｨ09ｨｰ06ｨｦ, 0904010205ｨｨｨｰ0205ｨｹｨｪ06ｨｦ, ｨｪ020809ｨｪ06ｨｦ, 05ｨｪ0106ｨｺ08ｨｨｨｪｨｪ06ｨｦ ｨｨ 0108ｨｮ00ｨｨ01 09ｨｨ09ｨｰ02ｨｬ 060800ｨ ｨｪｨｨ04ｨｬｨ. 0201ｨｪｨｨｨｬ ｨｨ04 070208090702ｨｺｨｰｨｨ09ｨｪ0401 ｨｨ ｨｬｨｪ06000606ｨ 02ｨｴｨ 06ｨｴｨｨ01 0706010106010609 010507 0708020106ｨｰ0908ｨ ｨｴ02ｨｪｨｨ07 08ｨ 0409ｨｨｨｰｨｨ07 0709ｨｪ060006 05022 0709050702ｨｰ0907 020006 0708020902ｨｪｨｰｨｨ09ｨｪ0602 0502 ﾂ02ｨｪｨｨ02 ｨｪｨ 09ｨｰｨ 01ｨｨｨｨ 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 08ｨ ｨｪｨｪ020006 05022, ｨｺ060001ｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 09 060800ｨ ｨｪｨｨ04ｨｬ02, 09040409ｨ ｨｪｨｪ0402 ｨｪｨ 08ｨ 09ｨｰｨ 06ｨｴ02ｨｦ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｹ06, 01ｨｨ0905ｨｨ07ｨｨ0102ｨｬｨｨ02ｨｦ ｨｨ 06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪ04ｨｬ 09ｨｰ0802090906ｨｬ, 02ｨｴ02 06ｨ 08ｨ ｨｰｨｨｨｬ04. 00 ｨｰ06 0302 090802ｨｬ07 0106 09ｨｨ01 070608 0609ｨｪ0609ｨｪ0602 09ｨｪｨｨｨｬｨ ｨｪｨｨ02 ｨｮ0102050706ｨｰ 0502 ﾂ02ｨｪｨｨ06 ｨｮ0302 08ｨ 0409ｨｨ09030200060907 04ｨ ｨ 06050209ｨ ｨｪｨｨ07, 010507 ｨｺ06ｨｰ0608060006 01ｨ 08ｨ ｨｺｨｰ0208ｨｪｨ ｨｰ07030205ｨ 07 09ｨｨｨｬ07ｨｰ06ｨｬｨ ｨｰｨｨｨｺｨ. 0308ｨｨ 05ｨｰ06ｨｬ ｨｺ06080802ｨｺ02ｨｨｨｨ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ01 ｨｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ, 090604ｨｪｨｨｨｺｨ 06ｨｴｨｨ01 ｨｪｨ 09ｨｰｨ 01ｨｨｨｨ 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 08ｨ ｨｪｨｪ020006 05022, 06ｨ 04 ﾂｨｪ06 ｨｪ02 ｨｮ0102050706ｨｰ 01060503ｨｪ060006 09ｨｪｨｨｨｬｨ ｨｪｨｨ07. 02ｨ ｨｴ020708ｨｨｨｪ07ｨｰ06ｨｦ 0709050702ｨｰ0907 ｨｰ06 ﾂｨｺｨ 040802ｨｪｨｨ07 06 ｨｰ06ｨｬ, ﾂｨｰ06 060708020102050706ｨｴｨｮ06 080605ｨｹ 09 05ｨｰｨｨ06050600ｨｨｨｨ ｨｨ 07ｨ ｨｰ060002ｨｪ020402 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022 ｨｨ0008ｨ 06ｨｰ ｨｨｨｪ09ｨｮ05ｨｨｨｪ0609ｨ 07 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｹ, 06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪ04ｨｦ 09ｨｰ08020909, 01ｨｨ0905ｨｨ07ｨｨ0102ｨｬｨｨ07, 05ｨｨ0706ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｹ. 0201ｨｪｨ ｨｺ06 09 070609050201ｨｪｨｨ02 00060104 ｨｪｨ ｨｺｨ 0705ｨｨ09ｨ 02ｨｰ0907 090902 ｨ 0605ｨｹ0302 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09 ｨｰ060006, ﾂｨｰ06 09ｨ 03ｨｪｨｮ06 080605ｨｹ 04010209ｨｹ ｨｨ0008ｨ 06ｨｰ 000608ｨｬ06ｨｪｨ 05ｨｹｨｪ0402 00ｨ ｨｺｨｰ060804 (Shpakov, Derkach, 2013). 030609ｨｺ0605ｨｹｨｺｨｮ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 09 000608ｨｬ06ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ09ｨｰ02ｨｬｨ 01 09040709050706ｨｰ0907 ｨｪｨ 09ｨｰｨ 01ｨｨｨｨ 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 08ｨ ｨｪｨｪ020006 05022, ｨｨ01 ｨｺ06080802ｨｺ02ｨｨ06 ｨｬ0603ｨｪ06 08ｨ 0909ｨｬｨ ｨｰ08ｨｨ09ｨ ｨｰｨｹ ｨｺｨ ｨｺ 0601ｨｨｨｪ ｨｨ04 07ｨｮｨｰ02ｨｦ 0708020902ｨｪｨｰｨｨ09ｨｪ060006 0502 ﾂ02ｨｪｨｨ07 ｨｨ 07080600ｨｨ05ｨ ｨｺｨｰｨｨｨｺｨｨ 05022. 00 070605ｨｪ06ｨｦ ｨｬ020802 05ｨｰ06 06ｨｰｨｪ0609ｨｨｨｰ0907 ｨｺ 000608ｨｬ06ｨｪｨ 05ｨｹｨｪ04ｨｬ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ04ｨｬ 09ｨｨ09ｨｰ02ｨｬｨ ｨｬ ｨｬ060400ｨ, ｨｺ06ｨｰ06080402 080200ｨｮ05ｨｨ08ｨｮ06ｨｰ0907 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ ｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ0607060106ｨ ｨｪ04ｨｬ 00ｨ ｨｺｨｰ060806ｨｬ 080609ｨｰｨ -1 (060804-1), 050207ｨｰｨｨｨｪ06ｨｬ, ｨｪ02ｨｦ0806070207ｨｰｨｨ01ｨ ｨｬｨｨ, ｨｬ06ｨｪ06ｨ ｨｬｨｨｨｪｨ ｨｬｨｨ ｨｨ ｨｪ02ｨｦ0806ｨｰ080600ｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ 00ｨ ｨｺｨｰ0608ｨ ｨｬｨｨ (Cole et al., 2007; de la Monte, 2009; de la Monte et al., 2010; Shpakov et al., 2011; Shpakov, 2012). 080506 ﾂ0209ｨｮ06 080605ｨｹ 04010209ｨｹ ｨｨ0008ｨ 06ｨｰ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 09 000608ｨｬ06ｨｪｨ 05ｨｹｨｪ06ｨｬ 09ｨｰｨ ｨｰｨｮ0902 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ09ｨ, 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0402 09ｨｨ09ｨｰ02ｨｬ04 ｨｺ06ｨｰ0608060006 ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｰ 09 080200ｨｮ050702ｨｨｨｨ 090902ｨｦ 000608ｨｬ06ｨｪｨ 05ｨｹｨｪ06ｨｦ 0902ｨｰｨｨ ｨｬ060400ｨ ｨｨ ﾂ02080204 ｨｪ0202 0906090502 ﾂ02ｨｪ04 09 ｨｺ06ｨｪｨｰ080605ｨｹ ｨｮ000502090601ｨｪ060006 ｨｨ 03ｨｨ080609060006 06ｨ ｨｬ02ｨｪ0609 09 070208ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 060800ｨ ｨｪｨ 01 ｨｨ ｨｰｨｺｨ ｨｪ0701 (Obici et al., 2002b; Gelling et al., 2006; Morton, 2007; Purkayastha et al., 2011; Meek, Morton, 2012; Abraham et al., 2013). 01ｨ 08ｨｮ0302ｨｪｨｨ07 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 000608ｨｬ06ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ09ｨｰ02ｨｬ ｨｬ060400ｨ 06ｨ ｨｮ090506090502ｨｪ04 ｨｬｨｪ0600ｨｨｨｬｨｨ 0708ｨｨ- ﾂｨｨｨｪｨ ｨｬｨｨ, 09080201ｨｨ ｨｺ06ｨｰ06080401 09ｨｪｨｨ0302ｨｪｨｨ02 ｨｮ080609ｨｪ07 000608ｨｬ06ｨｪ0609 ｨｨ ｨｪ02ｨｦ- 789
13790 08. 02. 0107ｨ ｨｺ0609 0806ｨｬ0201ｨｨｨ ｨｰ06080609, ｨｪｨ 08ｨｮ0302ｨｪｨｨ02 ｨｨ01 ｨｰ08ｨ ｨｪ09070608ｨｰｨ ｨｨ 07080602020909ｨｨｨｪ00ｨ 09 ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰｨｺｨ 01, ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ02 05ｨｺ090708020909ｨｨｨｨ ｨｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 ｨ 0205ｨｺ0609 ｪ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰ0609 05ｨｰｨｨ01 09ｨｨ09ｨｰ02ｨｬ. 000604ｨｪｨｨｨｺｨｪｨｮ09 09 0601ｨｪ06ｨｬ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｬ ｨｺｨ 09ｨｺｨ 0102, ｨｰｨ ｨｺｨｨ02 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 060109ｨ ｨｰ0409ｨ 06ｨｰ 090906 0902ｨｰｨｹ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ09ｨｰ02ｨｬ ｨｬ060400ｨ, ﾂｨｰ06 09020102ｨｰ ｨｺ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ06 0202ｨｪｨｰ08ｨ 05ｨｹｨｪ06ｨｦ 080200ｨｮ050702ｨｨｨｨ 00ｨｮｨｪｨｺ02ｨｨｨｦ 070208ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｰｨｺｨ ｨｪ02ｨｦ, 09ｨｪｨｨ0302ｨｪｨｨ06 ｨｨ01 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ ｨｨ 0108ｨｮ00ｨｨｨｬ 000608ｨｬ06ｨｪｨ ｨｬ, 000608ｨｬｨｨ080609ｨ ｨｪｨｨ06 0708020101ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺ060006 09ｨｨｨｬ07ｨｰ06ｨｬ06ｨｺ06ｨｬ070502ｨｺ09ｨ (Shpakov, 2012). 05090602090802ｨｬ02ｨｪｨｪ0602, ｨｪｨ 09ｨｰｨ 01ｨｨｨｨ 0708020101ｨｨｨ ｨ 02ｨｰｨ, 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨ02 00ｨｮｨｪｨｺ02ｨｨｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ09ｨｰ02ｨｬ ｨｬ060400ｨ 0907060906ｨ ｨｪ06 ｨｪ0608ｨｬｨ 05ｨｨ040609ｨ ｨｰｨｹ 0202ｨｪｨｰ08ｨ 05ｨｹｨｪｨｮ06 080200ｨｮ050702ｨｨ06 070208ｨｨ000208ｨｨ ﾂ0209ｨｺ060006 ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬｨ ｨｨ 0708020106ｨｰ0908ｨ ｨｰｨｨｨｰｨｹ 07020802010601 0708020101ｨｨｨ ｨ 02ｨｰｨ 09 0709ｨｪ04ｨｦ 05022. 0201ｨｪｨ ｨｺ06 010507 08ｨ 0408ｨ ｨ 06ｨｰｨｺｨｨ 05000002ｨｺｨｰｨｨ09ｨｪ0401 0706010106010609, 0706040906050706ｨｴｨｨ01 09060909ｨｰｨ ｨｪ0609ｨｨｨｰｨｹ 0202ｨｪｨｰ08ｨ 05ｨｹｨｪｨｮ06 080200ｨｮ050702ｨｨ06 ｨｪｨ 09ｨｰｨ 01ｨｨｨｨ 0708020101ｨｨｨ ｨ 02ｨｰｨ, ｨｪ0206ｨ 010601ｨｨｨｬ06 ｨｨ0102ｨｪｨｰｨｨ00ｨｨ02ｨｨ080609ｨ ｨｰｨｹ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 09 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ09ｨｰ02ｨｬｨ 01 ｨｬ060400ｨ, 090604ｨｪｨｨｨｺｨ 06ｨｴｨｨ02 ｨｪｨ 08ｨ ｨｪｨｪｨｨ01 09ｨｰｨ 01ｨｨ0701 01ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 07ｨ ｨｰ06050600ｨｨｨｨ, ｨ ｨｰｨ ｨｺ0302 09040709ｨｪｨｨｨｰｨｹ ｨｬ060502ｨｺｨｮ050708ｨｪ0402 0708ｨｨ ﾂｨｨｨｪ04 ｨｨ 07ｨ ｨｰ060002ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ02 07060905020109ｨｰ09ｨｨ07 ｨｰｨ ｨｺｨｨ01 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ. 01ｨ ｨｨｨ 0605ｨｹ03ｨｨｨｦ ｨｨｨｪｨｰ02080209 09 05ｨｰ06ｨｬ 06ｨｰｨｪ060302ｨｪｨｨｨｨ 0708020109ｨｰｨ 09050706ｨｰ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0402 09ｨｨ09ｨｰ02ｨｬ04 ｨｬ060400ｨ, 080200ｨｮ05ｨｨ08ｨｮ02ｨｬ0402 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ, 060804-1 ｨｨ 050207ｨｰｨｨｨｪ06ｨｬ, ｨｺ06ｨｰ06080402 ｨｨ0008ｨ 06ｨｰ ｨｨ09ｨｺ0506 ﾂｨｨｨｰ0205ｨｹｨｪ06 09ｨ 03ｨｪｨｮ06 080605ｨｹ 09 ｨｺ06ｨｪｨｰ08060502 05ｨｪ0106ｨｺ08ｨｨｨｪｨｪ06ｨｦ, ｨｪ020809ｨｪ06ｨｦ, 0902080102 ﾂｨｪ06-090609ｨｮ01ｨｨ09ｨｰ06ｨｦ ｨｨ 0108ｨｮ00ｨｨ01 09ｨｨ09ｨｰ02ｨｬ 060800ｨ ｨｪｨｨ04ｨｬｨ, 080200ｨｮ050702ｨｨｨｨ ｨｮ000502090601ｨｪ060006 ｨｨ 05ｨｨ07ｨｨ01ｨｪ060006 06ｨ ｨｬ02ｨｪ0609, 0202ｨｪｨｰ08ｨ 05ｨｹｨｪ06ｨｦ ｨｨ 070208ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ. 08ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｬｨｮ 090609ｨｰ0607ｨｪｨｨ06 05ｨｰｨｨ01 09ｨｨ09ｨｰ02ｨｬ ｨｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07ｨｬ 09 ｨｪｨｨ01 ｨｪｨ 09ｨｰｨ 01ｨｨｨｨ 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022 ｨｨ ｨ ｨｮ0102ｨｰ 0706090907ｨｴ02ｨｪ ｨｪｨ 09ｨｰ0607ｨｴｨｨｨｦ 06ｨ 040608. 0308ｨｨ ﾂｨｨｨｪ04 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ 000608ｨｬ06ｨｪｨ 05ｨｹｨｪ06ｨｦ 080200ｨｮ050702ｨｨｨｨ 09 ｨｬ06040002 09 ｨｮ09050609ｨｨ0701 01ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 07ｨ ｨｰ06050600ｨｨｨｨ 0308ｨｨ ﾂｨｨｨｪ04, ｨｺ06ｨｰ06080402 090201ｨｮｨｰ ｨｺ ｨｪｨ 08ｨｮ0302ｨｪｨｨ06 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ09ｨｰ02ｨｬ, 080200ｨｮ05ｨｨ08ｨｮ02ｨｬ0401 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ, 060804-1 ｨｨ 050207ｨｰｨｨｨｪ06ｨｬ, ｨｮ09050609ｨｪ06 ｨｬ0603ｨｪ06 08ｨ 04010205ｨｨｨｰｨｹ ｨｪｨ 010902 0008ｨｮ070704. 03020809ｨ 07 ｨｨ04 ｨｪｨｨ01 09ｨｺ0506 ﾂｨ 02ｨｰ 09 0902ｨ 07 ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ02 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07, 01ｨｨ0905ｨｨ07ｨｨ0102ｨｬｨｨ06 ｨｨ 06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪ04ｨｦ 09ｨｰ08020909, 0709050706ｨｴｨｨ020907 0905020109ｨｰ09ｨｨ02ｨｬ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｨ 00ｨｨ0702080005ｨｨｨｺ02ｨｬｨｨｨｨ, 09 ｨｰ06 090802ｨｬ07 ｨｺｨ ｨｺ 09ｨｰ0608ｨ 07 09090704ｨ ｨｪｨ 09 ｨｪｨ 08ｨｮ0302ｨｪｨｨ02ｨｬ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨｨ080609ｨ ｨｪｨｨ07 ｨｪ02ｨｦ0806ｨｬ0201ｨｨｨ ｨｰ0608ｨｪ0401 09ｨｨ09ｨｰ02ｨｬ ｨｬ060400ｨ, 080200ｨｮ05ｨｨ08ｨｮ02ｨｬ0401 ｨｬ06ｨｪ06ｨ ｨｬｨｨｨｪｨ ｨｬｨｨ ｨｨ ｨｪ02ｨｦ0806070207ｨｰｨｨ01ｨ ｨｬｨｨ, ｨｺ06ｨｰ06080402 0906090502 ﾂ02ｨｪ04 09 ｨｺ06ｨｪｨｰ080605ｨｹ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ, 060804-1 ｨｨ 050207ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ09ｨｰ02ｨｬ ｨｬ060400ｨ. 01ｨ ｨｨｨ 0605ｨｹ030202 04ｨｪｨ ﾂ02ｨｪｨｨ02 ｨｨｨｬ0206ｨｰ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 ｨｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07, 090604ｨｪｨｨｨｺｨ 06ｨｴｨｨ02 09 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ02ｨｦ0806ｨｪｨ 01, ｨｺ06ｨｰ06080402 ｨｨ0008ｨ 06ｨｰ ｨｺ0506 ﾂ0209ｨｮ06 080605ｨｹ 09 ｨｨｨｪｨｰ020008ｨｨ080609ｨ ｨｪｨｨｨｨ 09ｨｨ00ｨｪｨ 050609 09 000105 ｨｨ 06ｨ 02090702 ﾂ02ｨｪｨｨｨｨ 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ07 ｨｬ020301ｨｮ ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ06ｨｦ 0902ｨｰｨｹ06 ｨｬ060400ｨ ｨｨ 09ｨｨ00ｨｪｨ 05ｨ ｨｬｨｨ, 070609ｨｰｨｮ07ｨ 06ｨｴｨｨｨｬｨｨ 09 070208ｨｨ000208ｨｨｨｨ (Sahu, 2011; Williams et al., 2011). 0201ｨｪｨｨｨｬ ｨｨ04 09ｨ 03ｨｪ02ｨｦ03ｨｨ01 00ｨ ｨｺｨｰ06080609, 0904040409ｨ 06ｨｴｨｨ01 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ09ｨｰ02ｨｬ 09 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ02ｨｦ0806ｨｪｨ 01 09 ｨｮ09050609ｨｨ0701 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022, 0709050706ｨｰ0907 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 05ｨｨ07ｨｨ01ｨｪ060006 06ｨ ｨｬ02ｨｪｨ (Martinez de Morentin et al., 2010). 06ｨｺｨｰ0607ｨｨ ﾂ0209ｨｺ0602 ｨｪｨ ｨｺ06070502ｨｪｨｨ02 05ｨｨ07ｨｨ010609 09 b-ｨｺ0502ｨｰｨｺｨ 01 070601030205ｨｮ0106 ﾂｨｪ06ｨｦ 030205020404, 0702 ﾂ02ｨｪｨｨ, 090208010202, 09ｨｺ020502ｨｰｨｪ0401 ｨｬ040302ｨ 01, 0706 ﾂｨｺｨ 01 ｨｨ 0108ｨｮ00ｨｨ01 060800ｨ ｨｪｨ 01 09 ｨｮ09050609ｨｨ0701 0603ｨｨ0802ｨｪｨｨ07 ｨｨ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺ060006 09ｨｨｨｪ010806ｨｬｨ 09020102ｨｰ ｨｺ 05ｨｨ0706ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｨ, ﾂｨｰ06 09 01ｨ 05ｨｹｨｪ02ｨｦ0302ｨｬ 0904040409ｨ 02ｨｰ 09ｨｨ05ｨｹｨｪ06 090408ｨ 0302ｨｪｨｪｨｮ06 ｨｨｨｪ09ｨｮ05ｨｨｨｪ0609ｨｮ06 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｹ, ｨ ｨｰ0208060002ｨｪｨｪｨｮ06 01ｨｨ0905ｨｨ07ｨｨ0102ｨｬｨｨ06 ｨｨ 00ｨｨ070208ｨｨｨｪ09ｨｮ05ｨｨｨｪ02ｨｬｨｨ06. 00 ｨｺ06ｨｪ02 ﾂｨｪ06ｨｬ ｨｨｨｰ060002, 05ｨｨ0706ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｹ 0709050702ｨｰ0907 ｨｰ08ｨｨ0000020806ｨｬ 0708020101ｨｨｨ ｨ 02ｨｰｨ, 0709ｨｪ060006 05022 ｨｨ 020006 0609050603ｨｪ02ｨｪｨｨｨｦ ｪ 0902080102 ﾂｨｪ06-090609ｨｮ01ｨｨ09ｨｰ0401 04ｨ ｨ 06050209ｨ ｨｪｨｨｨｦ, 03ｨｨ08060906ｨｦ 01ｨｨ09ｨｰ080600ｨｨｨｨ 0702 ﾂ02ｨｪｨｨ ｨｨ 01ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｪ0200080607ｨ ｨｰｨｨｨｨ. 08ｨｮｨｪｨｺ02ｨｨ06 04ｨ ｨｴｨｨｨｰ04 070208ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｰｨｺｨ ｨｪ02ｨｦ 06ｨｰ 05ｨｺｨｰ0607ｨｨ- ﾂ0209ｨｺ060006 ｨｪｨ ｨｺ06070502ｨｪｨｨ07 05ｨｨ07ｨｨ010609 0904070605ｨｪ0706ｨｰ 050207ｨｰｨｨｨｪ ｨｨ 0108ｨｮ00ｨｨ02 ｨ 01ｨｨ0706ｨｺｨｨｨｪ04 (Minocci et al., 2000; Yadav et al., 2011). 01ｨ 08ｨｮ0302ｨｪｨｨ02 ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬｨ 05ｨｨ07ｨｨ010609 ｨｨ ｨｪｨ ｨｺ06070502ｨｪｨｨ02 ｨｨ01 070806ｨｨ04090601ｨｪ0401, ｨｪ0200ｨ ｨｰｨｨ09ｨｪ06 0905ｨｨ0706ｨｴｨｨ01 ｨｪｨ ｨ ｨｨ0601ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨ02 0708060202090904, 070806ｨｨ0901060107ｨｰ ｨｰｨ ｨｺ0302 ｨｨ 09 08ｨ 0405ｨｨ ﾂｨｪ0401 06ｨｰ010205ｨ 01 ｨｬ060400ｨ, ﾂｨｰ06 0708ｨｨ090601ｨｨｨｰ ｨｺ 0202ｨｪｨｰ08ｨ 05ｨｹｨｪ06ｨｦ 05ｨｨ0706ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｨ ｨｨ 0904040409ｨ 02ｨｰ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ. 01ｨ ｨｨｨ 0605ｨｹ030202 04ｨｪｨ ﾂ02ｨｪｨｨ02 ｨｨｨｬ0202ｨｰ 070608ｨ 0302ｨｪｨｨ02 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ02ｨｦ0806ｨｪ0609, ｨｺ06ｨｰ06080402 0709050706ｨｰ0907 0609ｨｪ0609ｨｪ04ｨｬｨｨ 0902ｨｪ090608ｨ ｨｬｨｨ 02ｨｨ08ｨｺｨｮ05ｨｨ08ｨｮ06ｨｴｨｨ01 09 ｨｺ080609ｨｨ 000506ｨｺ060404 ｨｨ 05ｨｨ07ｨｨ010609 ｨｨ 0609ｨｮｨｴ0209ｨｰ09050706ｨｰ ｨｬ0601ｨｮ050702ｨｨ06 05ｨｪ02080002ｨｰｨｨ ﾂ0209ｨｺ060006 0006ｨｬ020609ｨｰｨ 04ｨ 09 000105 ｨｨ 070208ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 060800ｨ ｨｪｨ 01 ｨｨ ｨｰｨｺｨ ｨｪ0701. 09ｨｨ0706ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｹ 09 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ0902 ｨｨ 0108ｨｮ00ｨｨ01 06ｨｰ010205ｨ 01 ｨｬ060400ｨ ｨｰｨ ｨｺ0302 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ 080204ｨｮ05ｨｹｨｰｨ ｨｰ06ｨｬ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 ｨｬ0601ｨｮ05ｨｨ08ｨｮ06ｨｴ020006 0905ｨｨ07ｨｪｨｨ07 080200ｨｮ0507ｨｰ0608ｨｪ0401 070207ｨｰｨｨ010609 ｨｨ 080609ｨｰ06090401 00ｨ ｨｺｨｰ06080609 ｨｪｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ01 07ｨｮｨｰ02ｨｦ 05ｨｪ01060002ｨｪｨｪ0401 03ｨｨ08ｨｪ0401 ｨｺｨｨ090506ｨｰ ｨｨ 05ｨｨ07ｨｨ010609. 00ｨ 03ｨｪ02ｨｦ03ｨｨｨｬｨｨ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰｨ ｨｬｨｨ 05ｨｰｨｨ01 07ｨｮｨｰ02ｨｦ 09 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ02ｨｦ0806ｨｪｨ 01 0709050706ｨｰ0907 000208ｨｬ02ｨｪｨｰ04 ｪ 080008-ｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ02ｨｬｨ 07 070806ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 04ｨ ｨｨ 09ｨｨｨｪｨｰｨ 04ｨ 03ｨｨ08ｨｪ0401 ｨｺｨｨ090506ｨｰ, ｨ ｨｰｨ ｨｺ0302 070806ｨｬ0203ｨｮｨｰ06 ﾂｨｪ0402 07080601ｨｮｨｺｨｰ04 ｨ ｨｨ0601ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨ01 0708020908ｨ ｨｴ02ｨｪｨｨｨｦ ｪ ｨｬｨ 0506ｨｪｨｨ05-ｨｺ0605ｨｪ04ｨｨｨｬ 08 ｨｨ ｨｺ0605ｨｪ04ｨｨｨｬ 08, 09060201ｨｨｨｪ02ｨｪｨｪ04ｨｦ 09 0105ｨｨｨｪｨｪ0602020706 ﾂ02 ﾂｨｪ04ｨｬｨｨ 03ｨｨ08ｨｪ06ｨｺｨｨ090506ｨｰｨｪ04ｨｬｨｨ 08ｨ 01ｨｨｨｺｨ 05ｨ ｨｬｨｨ (Martinez de Morentin et al., 2010). 09ｨｨ0706ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｹ 09 000105 0708ｨｨ090601ｨｨｨｰ ｨｺ 08ｨ 0409ｨｨｨｰｨｨ06 09ｨｰ08020909ｨ 05ｨｪ01060705ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ060006 0802ｨｰｨｨｨｺｨｮ05ｨｮｨｬｨ (050604), 010507 ｨｺ06ｨｰ0608060006 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ04 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 07080602020909ｨ ｨｺ06ｨｪ000608ｨｬｨ 02ｨｨ06ｨｪｨｪ060006 090604080209ｨ ｨｪｨｨ07 ｨ 0205ｨｺ0609 09 05ｨｪ01060705ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｬ 0802ｨｰｨｨｨｺｨｮ05ｨｮｨｬ02, 09ｨｪｨｨ0302ｨｪｨｨ02 ｨｨ01 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ, ｨ ｨｰｨ ｨｺ0302 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 09 05ｨｺ090708020909ｨｨｨｨ ｨ 0605ｨｹ03060006 ﾂｨｨ0905ｨ 0002ｨｪ0609. 00ｨ 03ｨｪｨｮ06 080605ｨｹ 09 08ｨ 0409ｨｨｨｰｨｨｨｨ 050604 ｨｨ0008ｨ 02ｨｰ 070609040302ｨｪｨｨ02 090601020803ｨ ｨｪｨｨ07 0006ｨｬ0602ｨｨ09ｨｰ02ｨｨｨｪｨ 09 0705ｨ 04ｨｬ02 ｨｺ080609ｨｨ 090905020109ｨｰ09ｨｨ02 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 06ｨｺｨｨ0905ｨｨｨｰ0205ｨｹｨｪ06-09060909ｨｰｨ ｨｪ0609ｨｨｨｰ0205ｨｹｨｪ060006 ｨ ｨ 05ｨ ｨｪ09ｨ ｨｨ 0706090802030102ｨｪｨｨ07 05ｨｪ0106ｨｰ0205ｨｨｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 09 ｨｮ09050609ｨｨ0701 ｨｮｨｬ020802ｨｪｨｪ06ｨｦ 00ｨｨ0702080005ｨｨｨｺ02ｨｬｨｨｨｨ ｨｨ 01ｨｨ0905ｨｨ07ｨｨ0102ｨｬｨｨｨｨ, ｨｺ06ｨｰ06080402 ｨｪｨ ｨ 050601ｨ 06ｨｰ0907 09 ｨｮ09050609ｨｨ0701 0603ｨｨ0802ｨｪｨｨ07, ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺ060006 09ｨｨｨｪ010806ｨｬｨ ｨｨ 0708020101ｨｨｨ ｨ 02ｨｰｨ. 040605ｨｹ 050604 09 08ｨ 0409ｨｨｨｰｨｨｨｨ 09ｨｨ05ｨｹｨｪ06 090408ｨ 0302ｨｪｨｪ06ｨｦ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ ｨｮ000502090601ｨｪ060006 06ｨ ｨｬ02ｨｪｨ, 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ0401 010507 05022, ｨ 0405ｨ 0708060102ｨｬ06ｨｪ09ｨｰ08ｨｨ080609ｨ ｨｪｨ 010507 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0401 ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ 070208ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｰｨｺｨ ｨｪ02ｨｦ ｨｨ 07ｨ ｨｪｨｺ0802ｨ ｨｰｨｨ ﾂ0209ｨｺｨｨ01 b-ｨｺ0502ｨｰ06ｨｺ (Ozcan et al., 2004; Huang et al., 2007; Wang et al., 2009). 00 01ｨ 05ｨｹｨｪ02ｨｦ0302ｨｬ ｨ 040506 0706ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨｨ04ｨ 04ｨｰ06 ﾂｨｪ0602 0706ｨｰ0802ｨ 0502ｨｪｨｨ02 07ｨｨｨｴｨｨ 0708ｨｨ090601ｨｨｨｰ ｨｺ 08ｨ 0409ｨｨｨｰｨｨ06 010806ｨｪｨｨ ﾂ0209ｨｺ060006 050604 09 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ0902 ｨｨ 0904040409ｨ 02ｨｰ 09ｨｪｨｨ0302ｨｪｨｨ02 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨｬ060400ｨ ｨｨ 070208ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｰｨｺｨ ｨｪ02ｨｦ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ ｨｨ 050207ｨｰｨｨｨｪｨｮ, ﾂｨｰ06 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ06 010507 0708020101ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺｨｨ01 090609ｨｰ0607ｨｪｨｨｨｦ (Zhang et al., 2008; Ozcan et al., 2009). 0206ｨｺｨ 04ｨ ｨｰ0205ｨｹ09ｨｰ0906ｨｬ 09 070605ｨｹ04ｨｮ 0904ｨ ｨｨｨｬ0609090704ｨｨ ｨｬ020301ｨｮ 050604 09 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ0902 ｨｨ 08ｨ 0409ｨｨｨｰｨｨ02ｨｬ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ 0709050706ｨｰ0907 080204ｨｮ05ｨｹｨｰｨ ｨｰ04, 070605ｨｮ ﾂ02ｨｪｨｪ0402 09 0706ｨｬ06ｨｴｨｹ06 00ｨ 08ｨｬｨ ｨｺ06050600ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｬ06010205ｨｨ 050604, 09040409ｨ ｨｪｨｪ06ｨｦ ｨｨｨｪｨｰ08ｨ 02020802ｨ 08ｨ 05ｨｹｨｪ04ｨｬ 0909020102ｨｪｨｨ02ｨｬ ｨｬ0403ｨ ｨｬ ｨｰｨ 0709ｨｨ00ｨ 0800ｨｨｨｪｨ, 09070202ｨｨ00ｨｨ ﾂ0209ｨｺ060006 ｨｨｨｪ00ｨｨｨ ｨｨｨｰ0608ｨ Ca 2+ -080604ｨ 0404 ｨｬ02ｨｬｨ 08ｨ ｨｪ04 05ｨｪ01060705ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ060006 0802ｨｰｨｨｨｺｨｮ05ｨｮｨｬｨ (Purkayastha et al., 2011). 02ｨ 0302 ｨｺ08ｨ ｨｰｨｺ06090802ｨｬ02ｨｪｨｪ04ｨｦ, 09 ｨｰ02 ﾂ02ｨｪｨｨ02 3 09ｨｮｨｰ, 050604 09 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ02ｨｦ0806ｨｪｨ 01 0904040409ｨ 05 ｨｪｨ 08ｨｮ0302ｨｪｨｨ02 ｨｰ06050208ｨ ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｺ 000506ｨｺ060402, 09ｨｨ09ｨｰ02ｨｬｨｪｨｮ06 ｨｨｨｪ09ｨｮ05ｨｨｨｪ0609ｨｮ06 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｹ ｨｨ 070609040302ｨｪｨｨ02 ｨ 08ｨｰ0208ｨｨｨ 05ｨｹｨｪ060006 01ｨ 090502ｨｪｨｨ07. 06ｨｪ00ｨｨｨ ｨｨ080609ｨ ｨｪｨｨ02 00ｨ ｨｺｨｰ0608ｨ NF-kB, ｨｺ06ｨｰ060804ｨｦ 0906090502 ﾂ02ｨｪ 09 ｨｬ060502ｨｺｨｮ050708ｨｪ0402 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ04 08ｨ 0409ｨｨｨｰｨｨ07 050604, ｨｨ 06ｨ 08ｨ ｨ 06ｨｰｨｺｨ 03ｨｨ0906ｨｰｨｪ0401 ｨｰｨ ｨｮ0806ｨｮ08090601020406ｨｺ09ｨｨ010605020906ｨｦ ｨｺｨｨ090506ｨｰ06ｨｦ ｪ ｨｬ06ｨｴｨｪ04ｨｬ ｨｨｨｪ00ｨｨｨ ｨｨｨｰ060806ｨｬ 050604 ｪ 070605ｨｪ0609ｨｰｨｹ06 0708020106ｨｰ0908ｨ ｨｴｨ 05ｨｨ ｨｪ0200ｨ ｨｰｨｨ09ｨｪ0602 0905ｨｨ07ｨｪｨｨ02 ｨｰｨ 0709ｨｨ00ｨ 0800ｨｨｨｪｨ ｨｪｨ 00ｨｮｨｪｨｺ02ｨｨｨｨ ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ (Purkayastha et al., 2011). 09ｨｨ0706ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｹ ｨｨ 050604 0904040409ｨ 06ｨｰ ｨｪｨ -
1305ｨｨ00ｨｪｨ 05ｨｹｨｪ0402 09ｨｨ09ｨｰ02ｨｬ04 ｨｬ060400ｨ, 080200ｨｮ05ｨｨ08ｨｮ02ｨｬ0402 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ, 060804-1 ｨｨ 050207ｨｰｨｨｨｪ06ｨｬ 791 08ｨｮ0302ｨｪｨｨ07 09 08ｨ 0405ｨｨ ﾂｨｪ0401 040902ｨｪｨｹ0701 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ, 060804-1 ｨｨ 050207ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ09ｨｰ02ｨｬ 09 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ02ｨｦ0806ｨｪｨ 01, ｨｬｨｪ0600ｨｨ02 ｨｨ04 ｨｺ06ｨｰ06080401 0709050706ｨｰ0907 06ｨ ｨｴｨｨｨｬｨｨ ｨｨ 0708ｨｨ09060107ｨｰ ｨｺ 09ｨｨ09ｨｰ02ｨｬｨｪ06ｨｦ 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｺ 070207ｨｰｨｨ01ｨ ｨｬ ｨｨｨｪ09ｨｮ05ｨｨｨｪ0609060006 0902ｨｬ02ｨｦ09ｨｰ09ｨ ｨｨ 050207ｨｰｨｨｨｪｨｮ. 08 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ06 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ 050207ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ09ｨｰ02ｨｬ ｨｬ060400ｨ ｨｬ0600ｨｮｨｰ ｨｰｨ ｨｺ0302 0708ｨｨ090601ｨｨｨｰｨｹ 000608ｨｬ06ｨｪｨ 05ｨｹｨｪ0402 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07, 090604ｨｪｨｨｨｺｨ 06ｨｴｨｨ02 09 0108ｨｮ00ｨｨ01 0202ｨｪｨｰ08ｨ 05ｨｹｨｪ0401 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ09ｨｰ02ｨｬｨ 01, 09 07020809ｨｮ06 06 ﾂ02080201ｨｹ 09 ｨｬ0205ｨ ｨｪ06ｨｺ0608ｨｰｨｨｨｪ060906ｨｦ, 09020806ｨｰ06ｨｪｨｨｨｪ020800ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｨ 010600ｨ ｨｬｨｨｨｪ020800ｨｨ ﾂ0209ｨｺ06ｨｦ (Lustman, Clouse, 2005; Nogueiras et al., 2007; Zhou et al., 2007; 0107ｨ ｨｺ0609, 2012; 0107ｨ ｨｺ0609, 020208ｨｺｨ ﾂ, 2012; Shpakov et al., 2012a, 2012b; Garber et al., 2013). 05010209ｨｹ 0708ｨ 0906ｨｬ0208ｨｪ06 0006090608ｨｨｨｰｨｹ 06 0202ｨｪｨｰ08ｨ 05ｨｹｨｪ06ｨｬ 0002ｨｪ020402 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022. 00 0609ｨｪ060902 05ｨｰ060006 050203ｨ ｨｰ ｨｰ0209ｨｪ0402 0904ｨ ｨｨｨｬ0609090704ｨｨ ｨｬ020301ｨｮ ｨｪ02ｨｦ0806ｨｬ0201ｨｨｨ ｨｰ0608ｨｪ04ｨｬｨｨ 09ｨｨ09ｨｰ02ｨｬｨ ｨｬｨｨ ｨｬ060400ｨ, ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 09 0601ｨｪ06ｨｦ ｨｨ05ｨｨ ｨｪ0209ｨｺ0605ｨｹｨｺｨｨ01 ｨｨ04 ｨｺ06ｨｰ06080401 0706 000708ｨｨｨｪ02ｨｨ07ｨｮ 0106ｨｬｨｨｨｪ0603 0708ｨｨ09060107ｨｰ ｨｺ 04ｨ 07ｨｮ09ｨｺｨｮ ｨｺ06ｨｬ0702ｨｪ09ｨ ｨｰ0608ｨｪ0401 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ0609 09 0108ｨｮ00ｨｨ01 09ｨｨ09ｨｰ02ｨｬｨ 01, ﾂｨｰ06 0907ｨｮ09ｨｰ07 0607080201020502ｨｪｨｪ0602 090802ｨｬ07 0904040409ｨ 02ｨｰ 010204ｨｨｨｪｨｰ020008ｨ 02ｨｨ06 090902ｨｦ 000608ｨｬ06ｨｪｨ 05ｨｹｨｪ06ｨｦ 0902ｨｰｨｨ ｨｬ060400ｨ. 080506- ﾂ0209ｨｮ06 080605ｨｹ 04010209ｨｹ ｨｨ0008ｨ 06ｨｰ ｨｺ06ｨｬ0702ｨｪ09ｨ ｨｰ0608ｨｪ0402 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 ｨ 0205ｨｺ0609 ｨｨ05ｨｨ ｨｨ01 ｨｺｨ 09ｨｺｨ 010609, ｨｺ06ｨｰ06080402 0709050706ｨｰ0907 06ｨ ｨｴｨｨｨｬｨｨ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰｨ ｨｬｨｨ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ09ｨｰ02ｨｬ, 080200ｨｮ05ｨｨ08ｨｮ02ｨｬ0401 08ｨ 0405ｨｨ ﾂｨｪ04ｨｬｨｨ 000608ｨｬ06ｨｪｨ ｨｬｨｨ ｨｨ ｨｪ02ｨｦ0806ｨｬ0201ｨｨｨ ｨｰ0608ｨ ｨｬｨｨ (Shpakov et al., 2011; Shpakov, 2012). 08ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0602 090609ｨｰ0607ｨｪｨｨ02 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ 060804-1 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ09ｨｰ02ｨｬ ｨｬ060400ｨ 09 ｨｮ09050609ｨｨ0701 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022 0608ｨ 01ｨｨ02ｨｨ06ｨｪｨｪ06 070208090609ｨｰ020702ｨｪｨｪ0602 04ｨｪｨ ﾂ02ｨｪｨｨ02 09 05ｨｰｨｨ06050600ｨｨｨｨ ｨｨ 07ｨ ｨｰ060002ｨｪ020402 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022 06ｨｰ090601ｨｨｨｰ0907 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｬｨｮ 090609ｨｰ0607ｨｪｨｨ06 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04. 0102 0709050702ｨｰ0907 ｨｨ09ｨｺ0506 ﾂ02ｨｪｨｨ02ｨｬ ｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ0609ｨ 07 09ｨｨ00ｨｪｨ 05ｨｹｨｪｨ 07 09ｨｨ09ｨｰ02ｨｬｨ ｨｬ060400ｨ, ｨｺ06ｨｰ0608ｨ 07 0906090502 ﾂ02ｨｪｨ 09 080200ｨｮ050702ｨｨ06 00ｨｮｨｪ01ｨ ｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06 ﾂｨｪ0401 070806020209090609 09 ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰｨｺｨ 01 ｨｨ ﾂ02080204 0202ｨｪｨｰ08ｨ 05ｨｹｨｪ0402 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ04 ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ02ｨｰ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ02 ｨｨ 080609ｨｰ06090402 0708060202090904 ｨｪｨ 070208ｨｨ000208ｨｨｨｨ, 09 ｨｰ06ｨｬ ﾂｨｨ090502 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ ｨｰｨｺｨ ｨｪ02ｨｦ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ. 01ｨ 08ｨｮ0302ｨｪｨｨ07 09 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ02 ｨｬ060400ｨ, 0904040409ｨ 06ｨｴｨｨ02 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｹ ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ, 09040709050706ｨｰ0907 ｨｪ02 ｨｰ0605ｨｹｨｺ06 0708ｨｨ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺ06ｨｬ 09ｨｨｨｪ010806ｨｬ02, 0708020101ｨｨｨ ｨ 02ｨｰ02 ｨｨ 05022, ｨｪ06 ｨｨ 0709050706ｨｰ0907 0601ｨｪ06ｨｦ ｨｨ04 ｨｺ0506 ﾂ02090401 0708ｨｨ ﾂｨｨｨｪ ｨ 06050204ｨｪｨｨ 0805ｨｹ020002ｨｦｨｬ0208ｨ, 08ｨ 0909ｨｬｨ ｨｰ08ｨｨ09ｨ 02ｨｬ06ｨｦ ｨｺｨ ｨｺ 0502 3-0006 ｨｰｨｨ07ｨ, ｨｨ 0108ｨｮ00ｨｨ01 ｨｪ02ｨｦ080601020002ｨｪ0208ｨ ｨｰｨｨ09ｨｪ0401 04ｨ ｨ 06050209ｨ ｨｪｨｨｨｦ (de la Monte, 2010; de la Monte, Tong, 2014). 0306ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 09 ｨｰｨｺｨ ｨｪ0701 ｨｬ060400ｨ ｨｨｨｬ0206ｨｰ0907 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06 ｨ ｨｺｨｰｨｨ09ｨｪ0402 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06090402 0802020207ｨｰ060804 (0604) (Boura-Halfon, Zick, 2009). 06ｨｪ09ｨｮ05ｨｨｨｪ, 09ｨｨｨｪｨｰ0204ｨｨ08ｨｮ02ｨｬ04ｨｦ 09 0609ｨｪ0609ｨｪ06ｨｬ b-ｨｺ0502ｨｰｨｺｨ ｨｬｨｨ 0609ｨｰ080609ｨｺ0609 09ｨ ｨｪ00020800ｨ ｨｪ09ｨ 070601030205ｨｮ0106 ﾂｨｪ06ｨｦ 030205020404, 050200ｨｺ06 070806ｨｪｨｨｨｺｨ 02ｨｰ 09 ｨｬ060400 ﾂ02080204 0002ｨｬｨ ｨｰ0605ｨｪ020200ｨ 05ｨｨ ﾂ0209ｨｺｨｨｨｦ ｨ ｨ 08ｨｹ0208, 090907040409ｨ 02ｨｰ0907 ｨｰｨ ｨｬ 09 0604, 09ｨｰｨｨｨｬｨｮ05ｨｨ08ｨｮ02ｨｰ ｨｨ01 ｨｰｨｨ080604ｨｨｨｪｨｺｨｨｨｪｨ 04ｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨ 0904040409ｨ 02ｨｰ 000609000608ｨｨ05ｨｨ080609ｨ ｨｪｨｨ02 ｨ 0205ｨｺ0609 ｪ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060802020207ｨｰ0608ｨｪ0401 09ｨｮｨ 09ｨｰ08ｨ ｨｰ0609 1-0006 ｨｨ 2-0006 ｨｰｨｨ070609 (IRS1 ｨｨ IRS2) (08ｨｨ09. 1). 06ｨｰ06 0708ｨｨ090601ｨｨｨｰ ｨｺ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨｨｨ ｨｪｨｨ0302050203ｨ ｨｴｨｨ01 05000002ｨｺｨｰ0608ｨｪ0401 ｨ 0205ｨｺ0609, ｨｺ06ｨｰ06080402 0906090502 ﾂ02ｨｪ04 09 ｨｺ06ｨｪｨｰ080605ｨｹ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 04ｨ 09ｨｨ09ｨｨｨｬ0401 06ｨｰ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪ0401 00ｨ ｨｺｨｰ06080609, 06ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ0401 04ｨ 080609ｨｰ, 01ｨｨ0000020802ｨｪ02ｨｨ080609ｨ ｨｪｨｨ02, ｨ 070607ｨｰ0604 ｨｨ 0108ｨｮ00ｨｨ02 00ｨｮｨｪ01ｨ ｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰ06 ﾂｨｪ0402 0708060202090904. 05010601ｨｪ04ｨｦ ｨｬ0201ｨ ｨｪｨｨ04ｨｬ 0102ｨｦ09ｨｰ09ｨｨ07 ｨｮ09ｨｰｨ ｨｪ06090502ｨｪ ｨｨ 010507 060804-1, ｨｺ06ｨｰ060804ｨｦ, ｨｰｨ ｨｺ 0302 ｨｺｨ ｨｺ ｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ, 06ｨｰｨｪ0609ｨｨｨｰ0907 ｨｺ 070207ｨｰｨｨ01ｨ ｨｬ ｨｨｨｪ09ｨｮ05ｨｨｨｪ0609060006 0902ｨｬ02ｨｦ09ｨｰ09ｨ. 060804-1 09ｨｨｨｪｨｰ0204ｨｨ08ｨｮ02ｨｰ0907 09 0702 ﾂ02ｨｪｨｨ ｨｨ ｨｬ06040002 ｨｨ 0609ｨｮｨｴ0209ｨｰ09050702ｨｰ 090906ｨｨ 080200ｨｮ0507ｨｰ0608ｨｪ0402 05000002ｨｺｨｰ04 ｨｪｨ ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0402 ｨｨ 0005ｨｨｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ ﾂ02080204 ｨｪｨ 01020502ｨｪｨｪ0402 ｨｰｨｨ080604ｨｨｨｪｨｺｨｨｨｪｨ 04ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 0802020207ｨｰ060804 060804-1 (060804104). 0604 ｨｨ 060804104 0506ｨｺｨ 05ｨｨ040609ｨ ｨｪ04 0906 ｨｬｨｪ0600ｨｨ01 06ｨｰ010205ｨ 01 ｨｬ060400ｨ 09 ｨｪｨ ｨｨｨ 0605ｨｹ0302ｨｦ ｨｨ01 070506ｨｰｨｪ0609ｨｰｨｹ06 09 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ0401 05ｨｮｨｺ0609ｨｨ02ｨ 01, 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ0902, 00ｨｨ070706ｨｺｨ ｨｬ0702 ｨｨ ｨｺ060802 0006050609ｨｪ060006 ｨｬ060400ｨ, ﾂｨｰ06 ｨｮｨｺｨ 040409ｨ 02ｨｰ ｨｪｨ ｨｺ0506 ﾂ0209ｨｮ06 080605ｨｹ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ ｨｨ 060804-1 09 ｨｺ06ｨｪｨｰ08060502 05ｨｪ02080002ｨｰｨｨ ﾂ0209ｨｺ060006 0006ｨｬ020609ｨｰｨ 04ｨ, 080200ｨｮ050702ｨｨｨｨ ｨｪ02ｨｦ08060002ｨｪ0204ｨ ｨｨ 09ｨｨｨｪｨ 07ｨｰ060002ｨｪ0204ｨ. 05ｨｨ00ｨｪｨ 05ｨｹｨｪ0402 09ｨｨ09ｨｰ02ｨｬ04 ｨｬ060400ｨ, 080200ｨｮ05ｨｨ08ｨｮ02ｨｬ0402 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ ｨｨ 060804-1, ｨｨｨｬ0206ｨｰ ｨｬｨｪ060006 06ｨ ｨｴｨｨ01 040902ｨｪｨｹ0209 ｨｨ ｨｰ0209ｨｪ06 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｮ06ｨｰ 09 0108ｨｮ00ｨｨｨｬｨｨ ｨｪ02ｨｦ0806ｨｬ0201ｨｨｨ ｨｰ0608ｨｪ04ｨｬｨｨ 09ｨｨ09ｨｰ02ｨｬｨ ｨｬｨｨ. 000905020109ｨｰ09ｨｨ02 05ｨｰ060006 ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨｨ 060804-1 060706090802010609ｨ ｨｪｨｪ06 ｨｮ ﾂｨ 09ｨｰ09ｨｮ06ｨｰ 09 ｨｺ06ｨｪｨｰ08060502 07ｨｨｨｴ0209060006 070609020102ｨｪｨｨ07, 07ｨ ｨｬ07ｨｰｨｨ, 06ｨ ｨｮ ﾂ02ｨｪｨｨ07, 01020708020909ｨｨ09ｨｪ0401 090609ｨｰ0607ｨｪｨｨｨｦ ｨｨ ｨｰ0208ｨｬ06080200ｨｮ050702ｨｨｨｨ, 09 080200ｨｮ050702ｨｨ06 ｨｺ06ｨｰ06080401 0906090502 ﾂ02ｨｪ06 ｨｬｨｪ06030209ｨｰ0906 0108ｨｮ00ｨｨ01 000608ｨｬ06ｨｪ0609 ｨｨ 080609ｨｰ06090401 00ｨ ｨｺｨｰ06080609. 02ｨｺｨ 040409ｨ 07 0905ｨｨ07ｨｪｨｨ02 ｨｪｨ 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ02 ｨｪ02ｨｦ0806ｨｪ04, ｨｨｨｪ09ｨｮ05ｨｨｨｪ ｨｨ 060804-1 ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ06ｨｰ 090902 0609ｨｪ0609ｨｪ0402 040902ｨｪｨｹ07 05ｨｪ0106ｨｺ08ｨｨｨｪｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04 ｨｨ 080200ｨｮ05ｨｨ08ｨｮ02ｨｬ0402 ﾂ02080204 ｨｪ0202 ｨ ｨｨ0601ｨｨｨｬｨｨ- ﾂ0209ｨｺｨｨ02 ｨｨ 00ｨｨ04ｨｨ06050600ｨｨ ﾂ0209ｨｺｨｨ02 0708060202090904 (D ｯErcole et al., 2002; Bondy, Cheng, 2004; Gerozissis, 2008). 0201ｨｪｨｨｨｬ ｨｨ04 09ｨ 03ｨｪ02ｨｦ03ｨｨ01 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 ｨｺｨ 09ｨｺｨ 010609, 080200ｨｮ05ｨｨ08ｨｮ02ｨｬ0401 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ ｨｨ 060804-1, 0709050702ｨｰ0907 3-0006090006ｨｨｨｪ0604ｨｨｨｰｨｨ01ｨｪ04ｨｦ 07ｨｮｨｰｨｹ, 09ｨｺ0506 ﾂｨ 06ｨｴｨｨｨｦ 09 0902ｨ 07 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06 09060708070302ｨｪｨｪｨｮ06 09 IRS-ｨ 0205ｨｺｨ ｨｬｨｨ p110/p85-0002ｨｰ02080601ｨｨｨｬ0208ｨｪｨｮ06 00060900ｨ ｨｰｨｨ01ｨｨ05ｨｨｨｪ0604ｨｨｨｰ0605-3-ｨｺｨｨｨｪｨ 04ｨｮ (PI3K), ｨｺｨ ｨｰｨ 05ｨｨ04ｨｨ08ｨｮ06ｨｴｨｮ06 06ｨ 08ｨ 040609ｨ ｨｪｨｨ02 09ｨｰ0608ｨｨ ﾂｨｪ0401 070609080201ｨｪｨｨｨｺ0609 00060900ｨ ｨｰｨｨ01ｨｨ05ｨｨｨｪ0604ｨｨｨｰ0605-3,4-01ｨｨ00060900ｨ ｨｰｨ ｨｨ 00060900ｨ ｨｰｨｨ01ｨｨ05ｨｨｨｪ0604ｨｨｨｰ0605-3,4,5-ｨｰ08ｨｨ00060900ｨ ｨｰｨ, ｨｨ 010902 090208ｨｨｨｪ/ｨｰ080206ｨｪｨｨｨｪ06090402 070806ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 0404 ｪ 3-0006090006ｨｨｨｪ0604ｨｨｨｰｨｨ0104ｨ 09ｨｨ09ｨｨｨｬｨｮ06 ｨｺｨｨｨｪｨ 04ｨｮ-1 ｨｨ 070806ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 04ｨｮ B (AKT-ｨｺｨｨｨｪｨ 04ｨｮ). 0004040409ｨ 02ｨｬｨ 07 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 AKTｨｺｨｨｨｪｨ 0404 0708ｨｨ090601ｨｨｨｰ ｨｺ ｨｰ08ｨ ｨｪ090506ｨｺｨ 02ｨｨｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ060006 ｨｰ08ｨ ｨｪ09070608ｨｰ0208ｨ GLUT4 09 0705ｨ 04ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺｨｮ06 ｨｬ02ｨｬｨ 08ｨ ｨｪｨｮ ｨｨ 0904040409ｨ 02ｨｰ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ06 04ｨ 0109ｨ ｨｰｨ 000506ｨｺ060404 ｨｺ0502ｨｰｨｺｨ ｨｬｨｨ. AKT-ｨｺｨｨｨｪｨ 04ｨ ｨｰｨ ｨｺ0302 ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ02ｨｰ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｺｨｨｨｪｨ 0404-3 0005ｨｨｨｺ060002ｨｪ09ｨｨｨｪｨｰ02ｨｰｨ 0404, ｨｺ06ｨｰ0608ｨ 07 080200ｨｮ05ｨｨ08ｨｮ02ｨｰ 09ｨｨｨｪｨｰ0204 090906ｨ 0601ｨｪ0401 03ｨｨ08ｨｪ0401 ｨｺｨｨ090506ｨｰ ｨｨ 0005ｨｨｨｺ060002ｨｪｨ, ｨｨｨｪ00ｨｨｨ ｨｨ08ｨｮ02ｨｰ ｨ 070607ｨｰ0604, 09ｨｰｨｨｨｬｨｮ05ｨｨ08ｨｮ02ｨｰ 090403ｨｨ09ｨ 02ｨｬ0609ｨｰｨｹ ｨｺ0502ｨｰ06ｨｺ ﾂ02080204 07060908020109ｨｰ0906 000609000608ｨｨ05ｨｨ080609ｨ ｨｪｨｨ07 ｨ 0205ｨｺ0609 BAD (BCL2 Antagonist of Cell Death) ｨｨ FKHRL1 (ForKHead-ReLated Family of Mammalian Transcription Factor-1). 01ｨ 080701ｨｮ 09 05ｨｰｨｨｨｬ AKT-ｨｺｨｨｨｪｨ 04ｨ ｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ02ｨｰ 070806ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 04ｨｮ mtor (mammalian Target Of Rapamycin), ﾂｨｰ06 0708ｨｨ090601ｨｨｨｰ ｨｺ 000609000608ｨｨ05ｨｨ080609ｨ ｨｪｨｨ06 08ｨｨｨ 060906ｨｬｨ 05ｨｹｨｪ06ｨｦ S6-ｨｺｨｨｨｪｨ 0404 ｨｨ 050203ｨｨｨｰ 09 0609ｨｪ060902 080200ｨｮ050702ｨｨｨｨ ｨｰ08ｨ ｨｪ09050702ｨｨｨｨ ｨｬｨｪ06030209ｨｰ09ｨ ｨｺ05ｨ 09090609 ｨｬ040108 (08ｨｨ09. 1). 0306ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨｬｨｨ0302ｨｪｨｹ06 AKT-ｨｺｨｨｨｪｨ 0404 0709050702ｨｰ0907 ｨ 020506ｨｺ FBP-1 (forkhead-box protein-1), ｨｪ0200ｨ ｨｰｨｨ09ｨｪ04ｨｦ 080200ｨｮ0507ｨｰ0608 ｨｨｨｪ09ｨｮ05ｨｨｨｪ0609060006 09ｨｨ00ｨｪｨ 05ｨｨｨｪ00ｨ, ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ07 ｨｺ06ｨｰ0608060006 0904040409ｨ 02ｨｰ ｨｮ09ｨｨ0502ｨｪｨｨ02 0706ｨｰ0802ｨ 0502ｨｪｨｨ07 07ｨｨｨｴｨｨ ｨｨ 0603ｨｨ0802ｨｪｨｨ02 (Kitamura et al., 2006). 00 06ｨｰ05ｨｨ ﾂｨｨ02 06ｨｰ 0502 1-0006 ｨｰｨｨ07ｨ, 010507 ｨｺ06ｨｰ0608060006 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ04 010200ｨｨ02ｨｨｨｰ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ ｨｨ 09ｨｪｨｨ0302ｨｪｨｨ02 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ 060804-1 09 ｨｬ06040002, 09 ｨｮ09050609ｨｨ0701 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ0401 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ ｨｮ080609ｨｪ07 05ｨｰｨｨ01 000608ｨｬ06ｨｪ0609 ｨｪ02 ｨ 040506 090407090502ｨｪ06 (Clauson et al., 1998; Varewijck et al., 2012). 05ｨｪｨｨ0302ｨｪｨｨ02 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨ ｨｨ06010609ｨｰｨｮ07ｨｪ060006 (090906ｨ 0601ｨｪ060006) 060804-1 ｨｪｨ ｨ 050601ｨ 05ｨｨ 0708ｨｨ 0105ｨｨｨｰ0205ｨｹｨｪ06 ｨｰ02ｨｺｨｮｨｴ02ｨｬ 05022 ｨｨ 09 ｨｮ09050609ｨｨ0701 ｨｪ02ｨ 0102ｨｺ09ｨ ｨｰｨｪ060006 0005ｨｨｨｺ02ｨｬｨｨ ﾂ0209ｨｺ060006 ｨｺ06ｨｪｨｰ08060507, 0708ｨｨ ﾂ02ｨｬ 0708ｨｨ ﾂｨｨｨｪ06ｨｦ 05ｨｰ060006 07090507050609ｨｹ ｨｪ02 09ｨｪｨｨ0302ｨｪｨｨ02 06ｨ ｨｴ020006 060804-1, ｨ 0109ｨｮｨｺ08ｨ ｨｰｨｪ0602 070609040302ｨｪｨｨ02 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ 060804-090907040409ｨ 06ｨｴ020006 ｨ 0205ｨｺｨ 1-0006 ｨｰｨｨ07ｨ (06080405091) (Clauson et al., 1998; Akturk et al., 2007). 06ｨｪｨｰ02080209ｨｪ06 07080609050201ｨｨｨｰｨｹ 01ｨｨｨｪｨ ｨｬｨｨｨｺｨｮ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ 06080405091 ｨｪｨ 08ｨ 0405ｨｨ ﾂｨｪ0401 09ｨｰｨ 01ｨｨ0701 08ｨ 0409ｨｨｨｰｨｨ07 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｨ 09090704ｨ ｨｪｨｪ0401 09 05ｨｰｨｨｨｬ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ01 08ｨ 0909ｨｰ0806ｨｦ09ｨｰ09. 06ｨ ｨｺ, ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 0603ｨｨ0802ｨｪｨｨ02ｨｬ, ｨｮ ｨｺ06ｨｰ06080401 06ｨｰｨｬ02- ﾂｨ 05ｨｨ 05ｨｨ03ｨｹ ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0602 09ｨｪｨｨ0302ｨｪｨｨ02 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨｰｨｺｨ ｨｪ02ｨｦ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ, ｨｮ08060902ｨｪｨｹ 06ｨ ｨｴ020006 060804-1 04ｨ ｨｬ02ｨｰｨｪ06 ｨｪ02 ｨｬ02ｨｪ07050907, 09 ｨｰ06 090802ｨｬ07 ｨｺｨ ｨｺ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ07 090906ｨ 0601ｨｪ060006 060804-1
13792 08. 02. 0107ｨ ｨｺ0609 04ｨｨ09. 1. 1,3-0006090006ｨｨｨｪ0604ｨｨｨｰｨｨ01ｨｪ0402 07ｨｮｨｰｨｨ, 080200ｨｮ05ｨｨ08ｨｮ02ｨｬ0402 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ. IRS1/2 ｪ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060802020207ｨｰ0608ｨｪ0402 09ｨｮｨ 09ｨｰ08ｨ ｨｰ04 1-0006 ｨｨ 2-0006 ｨｰｨｨ070609, PI3K ｪ 00060900ｨ ｨｰｨｨ01ｨｨ05ｨｨｨｪ0604ｨｨｨｰ0605-3-ｨｺｨｨｨｪｨ 04ｨ, PI-3,4,5-P 3 ｪ 00060900ｨ ｨｰｨｨ01ｨｨ05ｨｨｨｪ0604ｨｨｨｰ0605-3,4,5-ｨｰ08ｨｨ00060900ｨ ｨｰ, GLUT4 ｪ ｨｨｨｪ09ｨｮ05ｨｨｨｪ04ｨ 09ｨｨ09ｨｨｨｬ04ｨｦ 000506ｨｺ0604ｨｪ04ｨｦ ｨｰ08ｨ ｨｪ09070608ｨｰ0208 4-0006 ｨｰｨｨ07ｨ, PDK ｪ 0006090006ｨｨｨｪ0604ｨｨｨｰ060504ｨ 09ｨｨ09ｨｨｨｬｨ 07 070806ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 04ｨ, AKT ｪ 070806ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 04ｨ B (AKT-ｨｺｨｨｨｪｨ 04ｨ ), PKC ｪ 070806ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 04ｨ C, GSK3 ｪ ｨｺｨｨｨｪｨ 04ｨ -3 0005ｨｨｨｺ060002ｨｪ09ｨｨｨｪｨｰ02ｨｰｨ 0404, FKHRL1 ｪ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪ04ｨｦ 00ｨ ｨｺｨｰ0608-1 0902ｨｬ02ｨｦ09ｨｰ09ｨ Forkhead (For- KHead-ReLated Family of Mammalian Transcription Factor-1), BAD ｪ ｨ ｨｪｨｰｨ 0006ｨｪｨｨ09ｨｰ BCL2 09 ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 00ｨｨｨ 0205ｨｨ (BCL2 Antagonist of Cell Death), mtor ｪ 090208ｨｨｨｪ/ｨｰ080206ｨｪｨｨｨｪ0609ｨ 07 070806ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 04ｨ (mammalian Target Of Rapamycin), p70s6k ｪ p70-08ｨｨｨ 060906ｨｬｨ 05ｨｹｨｪｨ 07 S6-ｨｺｨｨｨｪｨ 04ｨ. ｨｪ02ｨｬｨｪ060006 0706090403ｨ 05ｨ 09ｨｹ 090905020109ｨｰ09ｨｨ02 09ｨｪｨｨ0302ｨｪｨｨ07 ｨｮ080609ｨｪ07 06080405091. 00 01ｨ 05ｨｹｨｪ02ｨｦ0302ｨｬ 0708ｨｨ ｨｮ09ｨｨ0502ｨｪｨｨｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｨ 08ｨ 0409ｨｨｨｰｨｨｨｨ 0708020101ｨｨｨ ｨ 02ｨｰｨ, ｨ 0907060905020109ｨｰ09ｨｨｨｨ ｨｨ 0709ｨｪ060006 05022 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ07 06080405091 0706090403ｨ 05ｨ 09ｨｹ, ﾂｨｰ06 0708ｨｨ090601ｨｨ0506 ｨｺ 09ｨｪｨｨ0302ｨｪｨｨ06 ｨｮ080609ｨｪ07 090906ｨ 0601ｨｪ060006 060804-1 (Frystyk et al., 1999). 0308ｨｨ ﾂｨｨｨｪ06ｨｦ 09ｨｪｨｨ0302ｨｪｨｨ07 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ 090906ｨ 0601ｨｪ060006 060804-1 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｰｨ ｨｺ0302 070609040302ｨｪｨｨ02 ｨｮ080609ｨｪ07 06080405093, ｨｪｨ ﾂｨｰ06 ｨｮｨｺｨ 040409ｨ 02ｨｰ 06ｨｰ ﾂ02ｨｰ05ｨｨ0906 090408ｨ 0302ｨｪｨｪ0602 09ｨｪｨｨ0302ｨｪｨｨ02 090606ｨｰｨｪ060302ｨｪｨｨ07 060804-1/06080405093 ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 05022 (Cortizo et al., 1998). 03080201070605ｨ 00ｨ 02ｨｰ0907, ﾂｨｰ06 070609040302ｨｪｨｨ02 ｨｮ080609ｨｪ07 08ｨ 0405ｨｨ ﾂｨｪ0401 000608ｨｬ 0608040509 09090704ｨ ｨｪ06 09 ｨｮ09ｨｨ0502ｨｪｨｨ02ｨｬ ｨｪ0205ｨｪ04ｨｨｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ060006 0005ｨｨｨｺ0604ｨｨ05ｨｨ080609ｨ ｨｪｨｨ07 05ｨｰｨｨ01 ｨ 0205ｨｺ0609 09 ｨｮ09050609ｨｨ0701 ｨｮｨｬ020802ｨｪｨｪ06ｨｦ 00ｨｨ0702080005ｨｨｨｺ02ｨｬｨｨｨｨ, ｨｺ06ｨｰ0608ｨ 07 01ｨ 08ｨ ｨｺｨｰ0208ｨｪｨ 010507 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022. 030609040302ｨｪｨｨ02 ｨｮ080609ｨｪ07 06080405091 09 ｨｮ09050609ｨｨ0701 0708020101ｨｨｨ ｨ 02ｨｰｨ 0706050603ｨｨｨｰ0205ｨｹｨｪ06 ｨｺ0608080205ｨｨ08ｨｮ02ｨｰ 09 08ｨ 0409ｨｨｨｰｨｨ02ｨｬ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ 09 000105 ｨｨ 070208ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 ｨｰｨｺｨ ｨｪ0701 ｨｨ ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｨ09070605ｨｹ040609ｨ ｨｪ06 09 ｨｺｨ ﾂ0209ｨｰ0902 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ060006 ｨｬｨ 08ｨｺ0208ｨ 010507 ｨｨ0102ｨｪｨｰｨｨ00ｨｨｨｺｨ 02ｨｨｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 ｨｪｨ 08ｨｮ0302ｨｪｨｪ06ｨｦ ｨｰ06050208ｨ ｨｪｨｰｨｪ0609ｨｰｨｹ06 ｨｺ 000506ｨｺ060402 ｨｨ 09ｨｪｨｨ0302ｨｪｨｪ06ｨｦ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ06, 07080201030209ｨｰ09ｨｮ06ｨｴｨｨ01 08ｨ 0409ｨｨｨｰｨｨ06 0709ｨｪ060006 05022 (Lopez-Bermejo et al., 2006; Ruan, Lai, 2010). 06ｨｬ0206ｨｰ0907 0609ｨｪ0609ｨ ｨｪｨｨ07 070605ｨ 00ｨ ｨｰｨｹ, ﾂｨｰ06 070609040302ｨｪｨｨ02 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ 06ｨ ｨｴ020006 07ｨｮ05ｨ 0608040509 0709050702ｨｰ0907 0601ｨｪ06ｨｦ ｨｨ04 0708ｨｨ ﾂｨｨｨｪ ｨｪ02090806050600ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ ｨｨ ｨｪ02ｨｦ080601020002ｨｪ0208ｨ ｨｰｨｨ09ｨｪ0401 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ, 090604ｨｪｨｨｨｺｨ 06ｨｴｨｨ01 09 ｨｮ09050609ｨｨ0701 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022, ｨｰ02ｨｬ ｨ 06050202 ﾂｨｰ06 09ｨｪｨｨ0302ｨｪｨｨ02 090606ｨｰｨｪ060302ｨｪｨｨ07 060804-1/0608040509 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ06 010507 ｨ 06050204ｨｪｨｨ 0805ｨｹ020002ｨｦｨｬ0208ｨ ｨｨ 090609ｨｮ01ｨｨ09ｨｰ06ｨｦ 0102ｨｬ02ｨｪ02ｨｨｨｨ, ｨｺ06ｨｰ06080402 ﾂｨ 09ｨｰ06 0909ｨｰ0802 ﾂｨ 06ｨｰ0907 ｨｮ 01ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺｨｨ01 07ｨ 02ｨｨ02ｨｪｨｰ0609 (Zhu et al., 2005). 06ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 09ｨｪｨｨ0302ｨｪｨｨ02 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ 090906ｨ 0601ｨｪ060006 060804-1 09 ｨｮ09050609ｨｨ0701 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 08ｨ ｨｪｨｪ020006 05022 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ 0601ｨｪｨｨｨｬ ｨｨ04 00ｨ ｨｺｨｰ06080609, 0904040409ｨ 06ｨｴｨｨ01 060905ｨ ｨ 0502ｨｪｨｨ02 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 060804-1-04ｨ 09ｨｨ09ｨｨｨｬ0401 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 07ｨｮｨｰ02ｨｦ 09 ｨｬ06040002. 0201ｨｪｨ ｨｺ06 06ｨ ｨｴ020708ｨｨｨｪ07ｨｰ06ｨｦ 0709050702ｨｰ0907 ｨｰ06 ﾂｨｺｨ 040802ｨｪｨｨ07 06 ｨｰ06ｨｬ, ﾂｨｰ06 0609ｨｪ0609ｨｪ04ｨｬｨｨ 0708ｨｨ ﾂｨｨｨｪｨ ｨｬｨｨ 09ｨｪｨｨ0302ｨｪｨｨ07 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 060804-1 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04 0708ｨｨ 05ｨｰｨｨ01 07ｨ ｨｰ06050600ｨｨ0701, ｨｺｨ ｨｺ ｨｨ 09 0905ｨｮ ﾂｨ 02 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04, 0709050706ｨｰ0907 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｨ01 0802020207ｨｰ0608ｨｪ0401 ｨｨ 05000002ｨｺｨｰ0608ｨｪ0401 ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰ0609. 07 ｨｬ040302ｨｦ, 05ｨｨ0302ｨｪｨｪ0401 0604 09 ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰｨｺｨ 01 (neuron-specific IR knockout, NIRKO), ｨｪｨ ｨ 050601ｨ 02ｨｰ0907 00ｨｨ07020800ｨ 00ｨｨ07 ｨｨ 08ｨ 0409ｨｨ09ｨ 02ｨｰ0907 04ｨ 09ｨｨ09ｨｨｨｬ0602 06ｨｰ 01ｨｨ02ｨｰ04 0708020101ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺ0602 090609ｨｰ0607ｨｪｨｨ02, ｨｺ06ｨｰ06080602 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ04ｨｮ02ｨｰ0907 070609040302ｨｪｨｨ02ｨｬ ｨｬｨ 090904 ｨｰ0205ｨ, 08ｨ 0409ｨｨｨｰｨｨ02ｨｬ ｨｮｨｬ020802ｨｪｨｪ06ｨｦ 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ, 00ｨｨ0702080005ｨｨｨｺ02ｨｬｨｨ02ｨｦ, 070609040302ｨｪｨｨ02ｨｬ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ, 050207ｨｰｨｨｨｪｨ ｨｨ ｨｰ08ｨｨ0005ｨｨ020208ｨｨ010609 (Bruning et al., 2000; Koch et al., 2008). 01ｨｨ07020800ｨ 00ｨｨ06 ｨｨ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ06 ｨｬｨ 090904 ｨｰ0205ｨ 0904040409ｨ 02ｨｰ ｨｨ 070601ｨ 090502ｨｪｨｨ02 05ｨｺ090708020909ｨｨｨｨ 0002ｨｪｨ, ｨｺ0601ｨｨ08ｨｮ06ｨｴ020006 0604, 09 06ｨｰ010205ｨｹｨｪ0401 070108ｨ 01 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ09ｨ ｨｬ040302ｨｦ (Obici et al., 2002a). 06ｨｰｨｨ 01ｨ ｨｪｨｪ0402 ｨｮｨｺｨ 040409ｨ 06ｨｰ ｨｪｨ ｨｺ0506 ﾂ0209ｨｮ06 080605ｨｹ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ ｨｬ060400ｨ 09 080200ｨｮ050702ｨｨｨｨ 00ｨｮｨｪｨｺ02ｨｨｨｦ 03ｨｨ08060906ｨｦ ｨｰｨｺｨ ｨｪｨｨ ｨｨ 07080601ｨｮｨｺ02ｨｨｨｨ 000506ｨｺ060404 0702 ﾂ02ｨｪｨｹ06. 07 09ｨ ｨｬ020609 ｨｬ040302ｨｦ, ｨｪ06ｨｺｨ ｨｮｨｰｨｪ0401 0706 0002ｨｪｨｮ 0604 09 ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰｨｺｨ 01, ｨｪｨ 08ｨｮ03ｨ 02ｨｰ0907 09070208ｨｬｨ ｨｰ060002ｨｪ0204 ｨｨ 09ｨｪｨｨ03ｨ 02ｨｰ0907 000208ｨｰｨｨ05ｨｹｨｪ0609ｨｰｨｹ, 09 ｨｰ06 090802ｨｬ07 ｨｺｨ ｨｺ ｨｮ 09ｨ ｨｬ06ｨｺ 0906 09010601ｨｪ06ｨｦ ｨｬｨｮｨｰｨ 02ｨｨ02ｨｦ ｨｪｨ 08ｨｮ03ｨ 02ｨｰ0907 07080602020909 090604080209ｨ ｨｪｨｨ07 00060505ｨｨｨｺｨｮ050708ｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 07ｨｨ ﾂｨｪｨｨｨｺ0609. 05ｨｪｨｨ0302ｨｪｨｨ02 080207080601ｨｮｨｺｨｰｨｨ09ｨｪ06ｨｦ 00ｨｮｨｪｨｺ02ｨｨｨｨ 0709050702ｨｰ0907 0905020109ｨｰ09ｨｨ02ｨｬ 060905ｨ ｨ 0502ｨｪｨｨ07 0902ｨｺ080202ｨｨｨｨ 08ｨｨ05ｨｨ04ｨｨｨｪ00-00ｨ ｨｺｨｰ0608ｨ 0506ｨｰ02ｨｨｨｪｨｨ04ｨｨ08ｨｮ06ｨｴ020006 000608ｨｬ06ｨｪｨ 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ ｨｪ02ｨｦ0806ｨｪｨ ｨｬｨｨ 09 ｨｮ09050609ｨｨ0701 ｨｪｨ 08ｨｮ0302ｨｪｨｪ060006 ｨｨｨｪ09ｨｮ05ｨｨｨｪ0609060006 09ｨｨ00ｨｪｨ 05ｨｨｨｪ00ｨ. 00060909ｨｰｨ ｨｪ06090502ｨｪｨｨ02 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 0604 ｨｮ
1305ｨｨ00ｨｪｨ 05ｨｹｨｪ0402 09ｨｨ09ｨｰ02ｨｬ04 ｨｬ060400ｨ, 080200ｨｮ05ｨｨ08ｨｮ02ｨｬ0402 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ, 060804-1 ｨｨ 050207ｨｰｨｨｨｪ06ｨｬ 793 ｨｪ06ｨｺｨ ｨｮｨｰｨｪ0401 ｨｬ040302ｨｦ 0708ｨｨ090601ｨｨｨｰ ｨｺ ｨｪ0608ｨｬｨ 05ｨｨ04ｨ 02ｨｨｨｨ 05ｨｪ02080002ｨｰｨｨ ﾂ0209ｨｺ060006 0006ｨｬ020609ｨｰｨ 04ｨ, 0708020106ｨｰ0908ｨ ｨｴｨ 02ｨｰ 08ｨ 0409ｨｨｨｰｨｨ02 0708020101ｨｨｨ ｨ 02ｨｰｨｨ- ﾂ0209ｨｺ060006 090609ｨｰ0607ｨｪｨｨ07 ｨｨ ﾂｨ 09ｨｰｨｨ ﾂｨｪ06 09060909ｨｰｨ ｨｪｨ 0905ｨｨ09ｨ 02ｨｰ ｨｨ01 080207080601ｨｮｨｺｨｰｨｨ09ｨｪ0402 00ｨｮｨｪｨｺ02ｨｨｨｨ (Okamoto et al., 2004). 06ｨｺ090708020909ｨｨ07 0002ｨｪｨ 0604 09 ｨｬ06040002 ｨｬ040302ｨｦ, ｨｪ06ｨｺｨ ｨｮｨｰｨｪ0401 0908ｨ 04ｨｮ 0706 0109ｨｮｨｬ 0002ｨｪｨ ｨｬ ｪ 0604 ｨｨ 000506ｨｺ0604ｨｪ060006 ｨｰ08ｨ ｨｪ09070608ｨｰ0208ｨ GLUT4, 0706090403ｨ 02ｨｰ ｨｨ01 090403ｨｨ09ｨ 02ｨｬ0609ｨｰｨｹ ｨｨ ｨｮ05ｨｮ ﾂ03ｨ 02ｨｰ 0706ｨｺｨ 04ｨ ｨｰ0205ｨｨ 05ｨｪ02080002ｨｰｨｨ ﾂ0209ｨｺ060006 06ｨ ｨｬ02ｨｪｨ, ｨｪ06 09 070605ｨｪ06ｨｦ ｨｬ020802 ｨｪ02 ｨｮ09ｨｰ08ｨ ｨｪ0702ｨｰ 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ0402 ﾂ0208ｨｰ04 0708020101ｨｨｨ ｨ 02ｨｰｨ, ﾂｨｰ06 09090704ｨ ｨｪ06 09 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨ02ｨｬ ｨｮ 03ｨｨ0906ｨｰｨｪ0401 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06 ｨ ｨｺｨｰｨｨ09ｨｪ060006 GLUT4, 06ｨ 02090702 ﾂｨｨ09ｨ 06ｨｴ020006 04ｨ 0109ｨ ｨｰ 000506ｨｺ060404 ｨｺ0502ｨｰｨｺｨ ｨｬｨｨ (Lin, Accili, 2011). 00 ｨｬ06040002 NIRKO-ｨｬ040302ｨｦ 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｮ02ｨｰ 09ｨｰｨｨｨｬｨｮ050702ｨｨ07 ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ PI3K, 09 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｦ 09ｨｰ020702ｨｪｨｨ 070601ｨ 090502ｨｪ06 000609000608ｨｨ05ｨｨ080609ｨ ｨｪｨｨ02 AKT-ｨｺｨｨｨｪｨ 0404 ｨｨ ｨｺｨｨｨｪｨ 0404-3b 0005ｨｨｨｺ060002ｨｪ09ｨｨｨｪｨｰ02ｨｰｨ 0404, 080204ｨｮ05ｨｹｨｰｨ ｨｰ06ｨｬ ﾂ020006 0709050702ｨｰ0907 ｨｮ09ｨｨ0502ｨｪｨｨ02 000609000608ｨｨ05ｨｨ080609ｨ ｨｪｨｨ07 ｨ 09090602ｨｨｨｨ080609ｨ ｨｪｨｪ060006 09 ｨｬｨｨｨｺ0806ｨｰ08ｨｮｨ 06 ﾂｨｺｨ ｨｬｨｨ Tau-ｨ 0205ｨｺｨ 0706 09ｨ ｨｦｨｰｨ ｨｬ, ｨｺ06ｨｰ06080402 09090704ｨ ｨｪ04 09 ｨｪ02ｨｦ080601020002ｨｪ0208ｨ ｨｰｨｨ09ｨｪ04ｨｬｨｨ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07ｨｬｨｨ 09 ｨｬ06040002 (Koch et al., 2008). 03080201070605ｨ 00ｨ 02ｨｰ0907, ﾂｨｰ06 09ｨ ｨｦｨｰ-09070202ｨｨ00ｨｨ ﾂｨｪ0602 000609000608ｨｨ05ｨｨ080609ｨ ｨｪｨｨ02 Tau-ｨ 0205ｨｺｨ 0709050702ｨｰ0907 0601ｨｪｨｨｨｬ ｨｨ04 ｨｬ0201ｨ ｨｪｨｨ04ｨｬ0609, ｨｺ06ｨｰ060804ｨｦ 090907040409ｨ 02ｨｰ 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ0402 010507 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｹ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ ｨｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 ｨｨｨｪ09ｨｮ05ｨｨｨｪ0609060006 09ｨｨ00ｨｪｨ 05ｨｨｨｪ00ｨ 09 08ｨ 0409ｨｨｨｰｨｨ02ｨｬ ｨｪ02ｨｦ080601020002ｨｪ0208ｨ ｨｰｨｨ09ｨｪ0401 04ｨ ｨ 06050209ｨ ｨｪｨｨｨｦ (Schubert et al., 2004). 00 ｨｬ06040002 00080404ｨｮｨｪ0609 09 ｨｪ020002ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ ｨｬ0601020507ｨｬｨｨ 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022, ｨｺ06ｨｰ06080402 0904040409ｨ 05ｨｨ 09040906ｨｺ0603ｨｨ08060906ｨｦ 01ｨｨ02ｨｰ06ｨｦ ｨｨ 0706ｨｰ0802ｨ 0502ｨｪｨｨ02ｨｬ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0401 ｨｺ0605ｨｨ ﾂ0209ｨｰ09 000506ｨｺ060404 ｨｨ 0008ｨｮｨｺｨｰ060404, 010609ｨｰ06090208ｨｪ0401 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ 05ｨｺ090708020909ｨｨｨｨ ｨｨ 090907040409ｨ 06ｨｴｨｨ01 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ09ｨｰｨｨｨｺ 0604 09 0908ｨ 09ｨｪ02ｨｪｨｨｨｨ 0906 04010608060904ｨｬｨｨ 03ｨｨ0906ｨｰｨｪ04ｨｬｨｨ 090407090502ｨｪ06 ｨｪ02 ｨ 040506 (Li et al., 2007). 030609ｨｺ0605ｨｹｨｺｨｮ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060904ｨｦ 09ｨｨ00ｨｪｨ 05ｨｨｨｪ00 09 ｨｬ06040002 ｨｮ ｨｪｨｨ01 ｨ 0405 060905ｨ ｨ 0502ｨｪ, ｨｪｨ 08ｨｮ0302ｨｪｨｨ07, ｨｺｨ ｨｺ ｨｬ0603ｨｪ06 070605ｨ 00ｨ ｨｰｨｹ, 0506ｨｺｨ 05ｨｨ040609ｨ ｨｪ04 09 0108ｨｮ00ｨｨ01 ｨ 0506ｨｺｨ 01 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04. 0308ｨｨ 05ｨｰ06ｨｬ 06ｨｰｨｬ02 ﾂｨ 05ｨｨ 04ｨ ｨｬ02ｨｰｨｪ0602 09ｨｪｨｨ0302ｨｪｨｨ02 05ｨｺ090708020909ｨｨｨｨ ｨｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 060804104, ﾂｨｰ06 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ02ｨｰ 06ｨ 060905ｨ ｨ 0502ｨｪｨｨｨｨ 060804-1 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04 09 ｨｬ06040002 01ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺｨｨ01 ｨｺ080409 (Li et al., 2007). 05050201ｨｮ02ｨｰ 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ, ﾂｨｰ06 ｨｪ020002ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ02 ｨｬ06010205ｨｨ 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022 ｨ 06050202 ｨ 05ｨｨ04ｨｺｨｨ 090606ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴｨｨｨｬ 04ｨ ｨ 06050209ｨ ｨｪｨｨ07ｨｬ ﾂ0205060902ｨｺｨ. 06ｨｪ000608ｨｬｨ 02ｨｨ07 09 06ｨｰｨｪ060302ｨｪｨｨｨｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ060006 090609ｨｰ0607ｨｪｨｨ07 IRS-ｨ 0205ｨｺ0609 09 ｨｬ06040002 09 ｨｮ09050609ｨｨ0701 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022 060008ｨ ｨｪｨｨ ﾂ02ｨｪｨｪｨ. IRS-ｨ 0205ｨｺｨｨ 0709050706ｨｰ0907 ｨｺ0506 ﾂ020904ｨｬ 040902ｨｪ06ｨｬ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨｰ08ｨ ｨｪ0901ｨｮｨｺ02ｨｨｨｨ, 070609ｨｺ0605ｨｹｨｺｨｮ 06ｨｪｨｨ ｨｪ02 ｨｰ0605ｨｹｨｺ06 0609ｨｮｨｴ0209ｨｰ09050706ｨｰ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0602 09060708070302ｨｪｨｨ02 ｨｬ020301ｨｮ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰｨ ｨｬｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ｨｨ 060804-1 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ09ｨｰ02ｨｬ, ｨｪ06 ｨｨ 06070609080201ｨｮ06ｨｰ cross-talk ｨｬ020301ｨｮ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ04ｨｬｨｨ 09ｨｨ09ｨｰ02ｨｬｨ ｨｬｨｨ ｨｬ060400ｨ, 080200ｨｮ05ｨｨ08ｨｮ02ｨｬ04ｨｬｨｨ 08ｨ 0405ｨｨ ﾂｨｪ04ｨｬｨｨ 000608ｨｬ06ｨｪｨ ｨｬｨｨ ｨｨ ｨｪ02ｨｦ0806ｨｬ0201ｨｨｨ ｨｰ0608ｨ ｨｬｨｨ. 05ｨｪｨｨ0302ｨｪｨｨ02 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ IRS-ｨ 0205ｨｺ0609 ｨｨ05ｨｨ ｨｨ01 0904ｨｺ0506 ﾂ02ｨｪｨｨ02 0708ｨｨ090601ｨｨｨｰ ｨｺ 08ｨ 0409ｨｨｨｰｨｨ06 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ, 00ｨｨ07020800ｨ 00ｨｨｨｨ, ｨｪｨ 08ｨｮ0302ｨｪｨｨ07ｨｬ ｨｮ000502090601ｨｪ060006 ｨｨ 05ｨｨ07ｨｨ01ｨｪ060006 06ｨ ｨｬ02ｨｪｨ ｨｨ 09 ｨｺ06ｨｪ02 ﾂｨｪ06ｨｬ ｨｨｨｰ060002 ｪ ｨｺ 0708020101ｨｨｨ ｨ 02ｨｰｨｮ ｨｨ 05022 (Lee, White, 2004). 0202050202ｨｨ07 0002ｨｪｨ irs2 09 ｨｪ02ｨｺ06ｨｰ06080401 06ｨｰ010205ｨ 01 ｨｬ060400ｨ ｨｬ040302ｨｦ, 09 ｨｰ06ｨｬ ﾂｨｨ090502 09 070108ｨ 01 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ09ｨ, 0904040409ｨ 02ｨｰ 070609040302ｨｪｨｨ02 ｨ 070702ｨｰｨｨｨｰｨ, ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 03ｨｨ08060906ｨｦ ｨｨ ｨｬ040302 ﾂｨｪ06ｨｦ ｨｬｨ 090904, ｨｮ09ｨｺ06080702ｨｰ 05ｨｨｨｪ02ｨｦｨｪ04ｨｦ 080609ｨｰ ｨｨ 0708ｨｨ090601ｨｨｨｰ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ. 070302 09 09060408ｨ 09ｨｰ02 6 ｪ10 ｨｬ0209 ｨｮ ｨｬ040302ｨｦ, ｨｪ06ｨｺｨ ｨｮｨｰｨｪ0401 0706 0002ｨｪｨｮ irs2, 09040709050705ｨｨ09ｨｹ 0708ｨｨ04ｨｪｨ ｨｺｨｨ 05022 (Lin et al., 2004). 05050201ｨｮ02ｨｰ 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ, ﾂｨｰ06 ｨｬｨｮｨｰｨ ｨｪｨｰｨｪ0402 ｨｬ0403ｨｨ ｨｨｨｬ0205ｨｨ 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ06 ｨｬ02ｨｪｨｹ03ｨｨ02 08ｨ 04ｨｬ020804 ｨｬ060400ｨ 090905020109ｨｰ09ｨｨ02 09ｨｪｨｨ0302ｨｪｨｨ07 07080605ｨｨ000208ｨ ｨｰｨｨ09ｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ, ｨｺ06ｨｰ0608ｨ 07 080200ｨｮ05ｨｨ08ｨｮ02ｨｰ0907 ﾂ02080204 IRS2-04ｨ 09ｨｨ09ｨｨｨｬ0402 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0402 07ｨｮｨｰｨｨ. 00 00ｨｨ070706ｨｺｨ ｨｬ0702 IRS2-010200ｨｨ02ｨｨｨｰｨｪ0401 ｨｬ040302ｨｦ 06ｨｰｨｬ02 ﾂｨ 05ｨｨ 09040906ｨｺｨｮ06 070506ｨｰｨｪ0609ｨｰｨｹ ｨｪ02ｨｦ080600ｨｨｨ 08ｨｨ05050708ｨｪ0401 ｨｺ05ｨｮｨ ｨｺ0609, 090601020803ｨ ｨｴｨｨ01 000609000608ｨｨ05ｨｨ080609ｨ ｨｪｨｪ0402 000608ｨｬ04 Tau-ｨ 0205ｨｺｨ, ﾂｨｰ06 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ06 010507 ｨｪ02ｨｦ080601020002ｨｪ0208ｨ ｨｰｨｨ09ｨｪ0401 04ｨ ｨ 06050209ｨ ｨｪｨｨｨｦ, 09 ｨｰ06ｨｬ ﾂｨｨ090502 010507 ｨ 06050204ｨｪｨｨ 0805ｨｹ020002ｨｦｨｬ0208ｨ (Schubert et al., 2003). 0308ｨｨ ﾂｨｨｨｪｨ 05ｨｰ060006 090609ｨｰ06ｨｨｨｰ 09 09ｨｪｨｨ0302ｨｪｨｨｨｨ ｨｪ02ｨｦ0806070806ｨｰ02ｨｺｨｰ0608ｨｪ060006 0102ｨｦ09ｨｰ09ｨｨ07 ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ ｨｨ 060804-1 ｨｪｨ 09ｨｰ08ｨｮｨｺｨｰｨｮ0804 ｨｬ060400ｨ, 0609ｨｮｨｴ0209ｨｰ09050702ｨｬ060006 ﾂ02080204 IRS2. 06ｨｬ0206ｨｰ0907 01ｨ ｨｪｨｪ0402 06 ｨｰ06ｨｬ, ﾂｨｰ06 ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 ｨｬｨｨｨｺ0806020200ｨ 05ｨｨ02ｨｦ ﾂｨ 09ｨｰ06 06ｨ ｨｪｨ 08ｨｮ03ｨｨ09ｨ 06ｨｰ0907 0706090802030102ｨｪｨｨ07 09 01ｨｨ09ｨｰｨ 05ｨｹｨｪ06ｨｦ ﾂｨ 09ｨｰｨｨ 010806ｨｬ060906ｨｬ04 13 (13q) 09ｨ 05ｨｨ04ｨｨ 0002ｨｪｨ irs2 ｨｬ020301ｨｮ ｨｬｨｨｨｺ080609ｨ ｨｰ020505ｨｨｨｰｨ ｨｬｨｨ D13S285 ｨｨ D13S1295, ｨ ｨ 06050202 01ｨｨ09ｨｰｨ 05ｨｹｨｪ0402 0102050202ｨｨｨｨ ｨｬ020301ｨｮ ｨｬｨｨｨｺ080609ｨ ｨｰ020505ｨｨｨｰｨ ｨｬｨｨ D13S274 ｨｨ D13S1311 09040709050706ｨｰ0907 ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 0906 ﾂ02ｨｰｨ ｨｪｨｪ04ｨｬｨｨ ｨｬｨｨｨｺ0806020200ｨ 05ｨｨ02ｨｦ ｨｨ 01020002ｨｺｨｰｨ ｨｬｨｨ 000608ｨｬｨｨ080609ｨ ｨｪｨｨ07 ｨｪ020809ｨｪ06ｨｦ ｨｰ08ｨｮｨ ｨｺｨｨ (Luo et al., 2000). 06ｨｰ06 ｨｮｨｺｨ 040409ｨ 02ｨｰ ｨｪｨ 09ｨ 03ｨｪｨｮ06 080605ｨｹ IRS2 ｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ06090401 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 ｨｺｨ 09ｨｺｨ 010609 09 080200ｨｮ050702ｨｨｨｨ 080609ｨｰｨ ｨｨ 01ｨｨ0000020802ｨｪ02ｨｨ080609ｨ ｨｪｨｨ07 ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 09 ｨｬ06040002 ﾂ0205060902ｨｺｨ. 020905ｨ ｨ 0502ｨｪｨｨ02 ｨｪｨｨ0302050203ｨ ｨｴｨｨ01 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 ｨｺｨ 09ｨｺｨ 010609, 09 07020809ｨｮ06 06 ﾂ02080201ｨｹ PI3K ｨｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06 09090704ｨ ｨｪｨｪ06ｨｦ 09 ｨｪ02ｨｦ AKT-ｨｺｨｨｨｪｨ 0404, ｨｰｨ ｨｺ0302 09ｨｪ0609ｨｨｨｰ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ04ｨｦ 09ｨｺ05ｨ 01 09 08ｨ 0409ｨｨｨｰｨｨ02 05022 ｨｨ ｨｪ02ｨｦ080601020002ｨｪ0208ｨ ｨｰｨｨ09ｨｪ0401 04ｨ ｨ 06050209ｨ ｨｪｨｨｨｦ, ｨ 09090602ｨｨｨｨ080609ｨ ｨｪｨｪ0401 09 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｹ06 (O ｯNeill, 2013). 0201ｨｪｨ ｨｺ06 070807ｨｬ0401 05ｨｺ09070208ｨｨｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ0401 0106ｨｺｨ 04ｨ ｨｰ0205ｨｹ09ｨｰ09 09 070605ｨｹ04ｨｮ 09ｨｪｨｨ0302ｨｪｨｨ07 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰ0609 3-0006090006ｨｨｨｪ0604ｨｨｨｰｨｨ01ｨｪ060006 07ｨｮｨｰｨｨ 09 ｨｬ06040002 0708ｨｨ 0708020101ｨｨｨ ｨ 02ｨｰ02 ｨｨ 05022 09 ｨｪｨ 09ｨｰ0607ｨｴ0202 090802ｨｬ07 ｨｪ02 070605ｨｮ ﾂ02ｨｪ06. 00 ｨｰ06 0302 090802ｨｬ07 ｨｨｨｬ0206ｨｰ0907 ｨｺ06090902ｨｪｨｪ0402 01ｨ ｨｪｨｪ0402 06 0904ｨ ｨｨｨｬ0609090704ｨｨ ｨｬ020301ｨｮ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07ｨｬｨｨ 09 05ｨｰ06ｨｬ 07ｨｮｨｰｨｨ ｨｨ 08ｨ 0409ｨｨｨｰｨｨ02ｨｬ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ, 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022. 0306ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 080200ｨｮ050702ｨｨ07 ｨｬ0205ｨ ｨｰ06ｨｪｨｨｨｪ06ｨｬ ｨｮ000502090601ｨｪ060006 0006ｨｬ020609ｨｰｨ 04ｨ 09ｨｺ0506 ﾂｨ 02ｨｰ 09 0902ｨ 07 020006 09070202ｨｨ00ｨｨ ﾂｨｪ0602 090907040409ｨ ｨｪｨｨ02 09 ｨｬ0205ｨ ｨｰ06ｨｪｨｨｨｪ060904ｨｬｨｨ 0802020207ｨｰ0608ｨ ｨｬｨｨ 09ｨｮ0708ｨ 01ｨｨｨ 04ｨｬｨ 05ｨｹｨｪ060006 070108ｨ 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ09ｨ, 06ｨｰ0902 ﾂｨ 06ｨｴ020006 04ｨ 0002ｨｪ0208ｨ 02ｨｨ06 02ｨｨ08ｨｺｨ 01ｨｪ0401 08ｨｨｨｰｨｬ0609, 09 070609050201ｨｮ06ｨｴ02ｨｦ ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ02ｨｦ 0604, IRS1 ｨｨ 04ｨ 09ｨｨ09ｨｨｨｬ0401 06ｨｰ ｨｪｨｨ01 ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰ0609 3-0006090006ｨｨｨｪ0604ｨｨｨｰｨｨ01ｨｪ060006 07ｨｮｨｰｨｨ (Anhe et al., 2004). 01ｨ 08ｨｮ0302ｨｪｨｨ02 ｨｬ0205ｨ ｨｰ06ｨｪｨｨｨｪ0609060006 09ｨｨ00ｨｪｨ 05ｨｨｨｪ00ｨ 09 0706ｨｬ06ｨｴｨｹ06 ｨ ｨｪｨｰｨ 0006ｨｪｨｨ09ｨｰ0609 ｨｬ0205ｨ ｨｰ06ｨｪｨｨｨｪ06090401 0802020207ｨｰ06080609 1-0006 ｨｨ 2-0006 ｨｰｨｨ070609 ｨｨ05ｨｨ 0708ｨｨ ｨｨｨｪｨｰ08ｨ 02020802ｨ 08ｨ 05ｨｹｨｪ06ｨｬ 0909020102ｨｪｨｨｨｨ ｨｨｨｪ00ｨｨｨ ｨｨｨｰ0608ｨ PI3K 0708ｨｨ090601ｨｨ0506 ｨｺ 09ｨｪ07ｨｰｨｨ06 ｨｨｨｪ00ｨｨｨ ｨｨ08ｨｮ06ｨｴ020006 0905ｨｨ07ｨｪｨｨ07 ｨｬ0205ｨ ｨｰ06ｨｪｨｨｨｪｨ ｨｪｨ 000506ｨｺ06ｨｪ02060002ｨｪ0204 09 0702 ﾂ02ｨｪｨｨ ｨｨ 0904040409ｨ 0506 070609040302ｨｪｨｨ02 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｰｨｺｨ ｨｪ02ｨｦ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ (Faria et al., 2013). 00 06ｨ 06ｨｨ01 0905ｨｮ ﾂｨ 0701 06ｨｰｨｬ02 ﾂｨ 05ｨｨ 09ｨｪｨｨ0302ｨｪｨｨ02 000609000608ｨｨ05ｨｨ080609ｨ ｨｪｨｨ07 AKT-ｨｺｨｨｨｪｨ 0404 09 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ0902 05ｨｺ09070208ｨｨｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ0401 03ｨｨ0906ｨｰｨｪ0401. 0009020102ｨｪｨｨ02 ｨｬ0205ｨ ｨｰ06ｨｪｨｨｨｪｨ, ｨｪｨ 070806ｨｰｨｨ09, 09 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｦ 09ｨｰ020702ｨｪｨｨ 0706090403ｨ 0506 000609000608ｨｨ05ｨｨ080609ｨ ｨｪｨｨ02 05ｨｰ060006 000208ｨｬ02ｨｪｨｰｨ. 05050201ｨｮ02ｨｰ 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ, ﾂｨｰ06 09ｨｪｨｨ0302ｨｪｨｨ02 ｨｮ080609ｨｪ07 ｨｬ0205ｨ ｨｰ06ｨｪｨｨｨｪｨ 06ｨｰｨｬ02 ﾂ02ｨｪ06 ｨｮ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｦ ﾂｨ 09ｨｰｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 0708020101ｨｨｨ ｨ 02ｨｰｨｨ- ﾂ0209ｨｺｨｨｨｬｨｨ 090609ｨｰ0607ｨｪｨｨ07ｨｬｨｨ ｨｨ 05022 (Srinivasan et al., 2013). 0906050202 ｨｰ060006, ｨｮ01ｨ 0502ｨｪｨｨ02 ｨｮ ｨｺ080409 03ｨｨ03ｨｺ0609ｨｨ01ｨｪ06ｨｦ 030205020404, 07080601ｨｮ02ｨｨ08ｨｮ06ｨｴ02ｨｦ ｨｬ0205ｨ ｨｰ06ｨｪｨｨｨｪ, 0708ｨｨ090601ｨｨｨｰ ｨｺ ｨｮ09ｨｨ0502ｨｪｨｨ06 000506ｨｺ06ｨｪ02060002ｨｪ0204ｨ ｨｨ ｨ 0409ｨｰ0806ｨｬｨｮ 08ｨ 0409ｨｨｨｰｨｨ06 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ 0702 ﾂ02ｨｪｨｨ, 0905020109ｨｰ09ｨｨ02ｨｬ ﾂ020006 0709050702ｨｰ0907 08ｨ 0409ｨｨｨｰｨｨ02 0708020101ｨｨｨ ｨ 02ｨｰｨ (Nogueira et al., 2011). 030605ｨｮ ﾂ02ｨｪｨｪ0402 01ｨ ｨｪｨｪ0402 ｨｮｨｺｨ 040409ｨ 06ｨｰ ｨｪｨ ｨｰ0209ｨｪｨｮ06 0904ｨ ｨｨｨｬ0609090704ｨｹ ｨｬ020301ｨｮ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07ｨｬｨｨ 02ｨｨ08ｨｺｨ 01ｨｪ060006 08ｨｨｨｰｨｬｨ ｨｨ 08ｨ 0409ｨｨｨｰｨｨ02ｨｬ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ0609ｨｰｨｨ, 09 0609ｨｪ060902 ﾂ020006 050203ｨｨｨｰ 060905ｨ ｨ 0502ｨｪｨｨ02 ｨｬ0205ｨ ｨｰ06ｨｪｨｨｨｪ06090401 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 07ｨｮｨｰ02ｨｦ 09 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ0902, 080200ｨｮ05ｨｨ08ｨｮ06ｨｴｨｨ01 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ PI3K, ｨｨ 04ｨ 09ｨｨ09ｨｨｨｬ0401 06ｨｰ ｨｪ0202 05000002ｨｺｨｰ0608ｨｪ0401 ｨ 0205ｨｺ0609 ｨｨ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪ0401 00ｨ ｨｺｨｰ06080609 (Lucassen et al., 2012). 0201ｨｪｨｨｨｬ ｨｨ04 0706010106010609, ｨｪｨ 0708ｨ 090502ｨｪｨｪ0401 ｨｪｨ 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨ02 ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04 ｨｬ060400ｨ 09 ｨｮ09050609ｨｨ0701 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022, 0709050702ｨｰ0907 070609040302ｨｪｨｨ02 ｨｮ080609ｨｪ07 ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ 09 ｨｬ06040002 090905020109ｨｰ09ｨｨ02 020006 ｨｨｨｪｨｰ08ｨ 02020802ｨ 08ｨ 05ｨｹｨｪ060006 ｨｨ05ｨｨ ｨｨｨｪｨｰ08ｨ ｨｪｨ 04ｨ 05ｨｹｨｪ060006 0907060906ｨ ｨ 0909020102ｨｪｨｨ07, 0708ｨｨ ﾂ02ｨｬ 09 ｨｰ06 ﾂｨｺｨｨ 040802ｨｪｨｨ07 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ 0708ｨ ｨｺｨｰｨｨｨｺｨｨ ｨｨｨｪｨｰ08ｨ ｨｪｨ 04ｨ 05ｨｹｨｪ0602 0909020102ｨｪｨｨ02 ｨ 06050202 070802010706 ﾂｨｰｨｨｨｰ0205ｨｹｨｪ06 (Subramanian, John, 2012; de la Monte, 2013; Novak et al., 2014). 01ｨ ｨｬｨｨ 0708ｨｨ 0105ｨｨｨｰ0205ｨｹｨｪ06ｨｬ 0502 ﾂ02ｨｪｨｨｨｨ ｨｺ080409 09 ｨｪ0206ｨｪｨ ｨｰｨ 05ｨｹｨｪ06ｨｦ ｨｬ06010205ｨｹ06 05022 09 0706ｨｬ06ｨｴｨｹ06 ｨｨｨｪｨｰ08ｨ ｨｪｨ 04ｨ 05ｨｹｨｪ060006 ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ (09ｨｮｨｰ06 ﾂｨｪｨ 07 010604ｨ 0.48 0302 ｨｪｨ ｨｺ080409ｨｮ) ｨ 040506 0706ｨｺｨ 04ｨ -
13794 08. 02. 0107ｨ ｨｺ0609 ｨｪ06, ﾂｨｰ06 ｨｮ0302 ｨｪｨ ｨｪｨ ﾂｨ 05ｨｹｨｪ0401, 0708020101ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺｨｨ01, 09ｨｰｨ 01ｨｨ0701 ｨｮ 03ｨｨ0906ｨｰｨｪ0401 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ06 ｨｮ05ｨｮ ﾂ03ｨ 02ｨｰ0907 0005ｨｨｨｺ02ｨｬｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｺ06ｨｪｨｰ080605ｨｹ, ﾂｨｰ06 090408ｨ 03ｨ 050609ｨｹ 09 ｨｪ0608ｨｬｨ 05ｨｨ04ｨ 02ｨｨｨｨ ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨｰｨｺｨ ｨｪ02ｨｦ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ ｨｨ ｨｮ080609ｨｪ07 000506ｨｺ060404 (Shpakov et al., 2012; 0107ｨ ｨｺ0609 ｨｨ 0108., 2013). 0308ｨｨ 05ｨｰ06ｨｬ ｨｪｨ ｨ 050601ｨ 05ｨｨ 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨ02 000608ｨｬ06ｨｪｨ 05ｨｹｨｪ06ｨｦ ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨ 0102ｨｪｨｨ05ｨ ｨｰ02ｨｨｨｺ05ｨ 04ｨｪ06ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04 09 ｨｬ06040002 01ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺｨｨ01 ｨｺ080409, ｨｺ06ｨｰ0608ｨ 07 07060109020800ｨ 05ｨ 09ｨｹ 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ04ｨｬ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07ｨｬ 09 ｨｮ09050609ｨｨ0701 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022. 030609ｨｺ0605ｨｹｨｺｨｮ ｨｨ04ｨｮ ﾂ02ｨｪｨｪ0402 ｨｪｨ ｨｬｨｨ 000608ｨｬ06ｨｪ04, 080200ｨｮ0507ｨｰ060804 ｨ 0102ｨｪｨｨ05ｨ ｨｰ02ｨｨｨｺ05ｨ 04ｨｪ06ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04, ｨｰｨ ｨｺｨｨ02 ｨｺｨ ｨｺ 09020806ｨｰ06ｨｪｨｨｨｪ, 010600ｨ ｨｬｨｨｨｪ, ｨｪ0608ｨ 010802ｨｪｨ 05ｨｨｨｪ, 0906ｨｬｨ ｨｰ0609ｨｰｨ ｨｰｨｨｨｪ ｨｨ 080205ｨ ｨｺ09ｨｨｨｪ, ｨｪ0207060908020109ｨｰ0902ｨｪｨｪ06 0906090502 ﾂ02ｨｪ04 09 080200ｨｮ050702ｨｨ06 00ｨｮｨｪｨｺ02ｨｨｨｦ 000105, 05ｨｪ0106ｨｺ08ｨｨｨｪｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04, 05ｨｪ02080002ｨｰｨｨ ﾂ0209ｨｺ060006 06ｨ ｨｬ02ｨｪｨ, 0202ｨｪｨｰ08ｨ 05ｨｹｨｪ06ｨｦ ｨｨ 070208ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｨｨｪ09ｨｮ05ｨｨｨｪ060906ｨｦ ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ, 09060909ｨｰｨ ｨｪ06090502ｨｪｨｨ02 080200ｨｮ05ｨｨ08ｨｮ02ｨｬ0401 ｨｨｨｬｨｨ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 ｨｺｨ 09ｨｺｨ 010609 09 ｨｬ06040002 09 0706ｨｬ06ｨｴｨｹ06 0105ｨｨｨｰ0205ｨｹｨｪ060006 0502 ﾂ02ｨｪｨｨ07 01ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺｨｨ01 ｨｺ080409 ｨｨｨｪｨｰ08ｨ ｨｪｨ 04ｨ 05ｨｹｨｪ04ｨｬ ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ 0706040906050702ｨｰ 07080201ｨｮ07080201ｨｨｨｰｨｹ 03ｨｨ0806ｨｺｨｨｨｦ 090702ｨｺｨｰ08 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ ｨｨ 0609050603ｨｪ02ｨｪｨｨｨｦ, ｨ 09090602ｨｨｨｨ080609ｨ ｨｪｨｪ0401 09 0708020101ｨｨｨ ｨ 02ｨｰ06ｨｬ ｨｨ 05022. 0605050609ｨｰ08ｨ 02ｨｨ02ｨｦ 05ｨｰ060006 0709050702ｨｰ0907 ｨｰ06ｨｰ 00ｨ ｨｺｨｰ, ﾂｨｰ06 0502 ﾂ02ｨｪｨｨ02 ｨｨｨｪｨｰ08ｨ ｨｪｨ 04ｨ 05ｨｹｨｪ04ｨｬ ｨｨｨｪ09ｨｮ05ｨｨｨｪ06ｨｬ 09 04ｨｪｨ - ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｦ 09ｨｰ020702ｨｪｨｨ 09060909ｨｰｨ ｨｪｨ 0905ｨｨ09ｨ 02ｨｰ ｨｺ0600ｨｪｨｨｨｰｨｨ09ｨｪ0402 00ｨｮｨｪｨｺ02ｨｨｨｨ (07080609ｨｰ08ｨ ｨｪ09ｨｰ0902ｨｪｨｪｨｮ06 07ｨ ｨｬ07ｨｰｨｹ, 0907060906ｨ ｨｪ0609ｨｰｨｹ ｨｺ 06ｨ ｨｮ ﾂ02ｨｪｨｨ06) ｨｮ ｨｺ080409 09 05022 (05ｨｮ010609 ｨｨ 0108., 2013). 0709ｨｰｨ ｨｪ06090502ｨｪ06 ｨｰｨ ｨｺ0302, ﾂｨｰ06 ｨｨｨｪｨｰ08ｨ ｨｪｨ 04ｨ 05ｨｹｨｪ04ｨｦ ｨｨｨｪ09ｨｮ05ｨｨｨｪ 070601ｨ 09050702ｨｰ 05ｨｨ070605ｨｨ04 09 ｨ 020506ｨｦ 03ｨｨ08060906ｨｦ ｨｰｨｺｨ ｨｪｨｨ, 09 0609ｨｪ060902 ﾂ020006 050203ｨｨｨｰ 070609040302ｨｪｨｨ02 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ ｨ 01ｨｨ070602ｨｨｨｰ0609 ｨｺ 0102ｨｦ09ｨｰ09ｨｨ06 ｨｨｨｪ09ｨｮ05ｨｨｨｪｨ, ﾂｨｰ06 09020102ｨｰ ｨｺ ｨｪ0608ｨｬｨ 05ｨｨ04ｨ 02ｨｨｨｨ 05ｨｨ07ｨｨ01ｨｪ060006 06ｨ ｨｬ02ｨｪｨ ｨｨ 09ｨｪｨｨ0302ｨｪｨｨ06 05ｨｨ0706ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｨ ｨｨ 0907060906ｨ ｨｪ06, ｨｰｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 0708020106ｨｰ0908ｨ ｨｰｨｨｨｰｨｹ 07020802010601 0708020101ｨｨｨ ｨ 02ｨｰｨ 09 0709ｨｪ04ｨｦ 05022 (Iwen et al., 2014). 08ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0602 090609ｨｰ0607ｨｪｨｨ02 050207ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04 ｨｬ060400ｨ 09 ｨｮ09050609ｨｨ0701 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022 090207ｨｰｨｨｨｪ, 07080601ｨｮｨｺｨｰ 0002ｨｪｨ ob, 0902ｨｺ0802ｨｰｨｨ08ｨｮ02ｨｬ04ｨｦ 070802ｨｨｨｬｨｮｨｴ0209ｨｰ0902ｨｪｨｪ06 070208ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨｨｬｨｨ ｨ 01ｨｨ070602ｨｨｨｰｨ ｨｬｨｨ, 080200ｨｮ05ｨｨ08ｨｮ02ｨｰ 05ｨｪ02080002ｨｰｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬ ｨｨ ｨｬｨ 0909ｨｮ ｨｰ0205ｨ. 030006 010200ｨｨ02ｨｨｨｰ ｨｮ ﾂ0205060902ｨｺｨ ｨｨ 05ｨｺ09070208ｨｨｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ0401 03ｨｨ0906ｨｰｨｪ0401 0708ｨｨ090601ｨｨｨｰ ｨｺ ｨｰ0703020504ｨｬ 000608ｨｬｨ ｨｬ 0603ｨｨ0802ｨｪｨｨ07. 090207ｨｰｨｨｨｪ 070806ｨｪｨｨｨｺｨ 02ｨｰ 09 ｨｬ060400 ﾂ02080204 0002ｨｬｨ ｨｰ0605ｨｪ020200ｨ 05ｨｨ ﾂ0209ｨｺｨｨｨｦ ｨ ｨ 08ｨｹ0208 090905020109ｨｰ09ｨｨ02 0802020207ｨｰ060806070609080201ｨｮ02ｨｬ060006 05ｨｪ010602ｨｨｨｰ0604ｨ. 06ｨ ｨｬ 06ｨｪ 090907040409ｨ 02ｨｰ0907 09 0802020207ｨｰ0608ｨ ｨｬｨｨ 050207ｨｰｨｨｨｪｨ, 0506ｨｺｨ 05ｨｨ040609ｨ ｨｪｨｪ04ｨｬｨｨ 09 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ02ｨｦ0806ｨｪｨ 01, 010507 ｨｺ06ｨｰ06080401 01ｨ 08ｨ ｨｺｨｰ0208ｨｪｨ 09040906ｨｺｨ 07 ｨｨ01 070506ｨｰｨｪ0609ｨｰｨｹ, ｨ ｨｰｨ ｨｺ0302 09 0802020207ｨｰ0608ｨ ｨｬｨｨ 050207ｨｰｨｨｨｪｨ, 08ｨ 09070605060302ｨｪｨｪ04ｨｬｨｨ 09 0108ｨｮ00ｨｨ01 06ｨｰ010205ｨ 01 ｨｬ060400ｨ ｪ ｨｺ060802, ｨｰｨ 05ｨ ｨｬｨｮ0902, ｨｬ06040302 ﾂｨｺ02, 06ｨ 06ｨｪ07ｨｰ0205ｨｹｨｪ0401 05ｨｮｨｺ0609ｨｨ02ｨ 01 ｨｨ 090609ｨｮ01ｨｨ09ｨｰ06ｨｬ 09070502ｨｰ02ｨｪｨｨｨｨ (Mutze et al., 2006; Marino et al., 2011). 090207ｨｰｨｨｨｪ06090402 0802020207ｨｰ060804 06ｨｰｨｪ060907ｨｰ0907 ｨｺ 0902ｨｬ02ｨｦ09ｨｰ09ｨｮ 02ｨｨｨｰ06ｨｺｨｨｨｪ06090401 0802020207ｨｰ06080609 ｨｨ ｨｨｨｬ0206ｨｰ ｨｪ0209ｨｺ0605ｨｹｨｺ06 ｨｨ0406000608ｨｬ, ｨｪ06 ｨｰ0605ｨｹｨｺ06 070605ｨｪ0608ｨ 04ｨｬ0208ｨｪｨ 07 000608ｨｬｨ 0802020207ｨｰ0608ｨ 0709050702ｨｰ0907 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06 ｨ ｨｺｨｰｨｨ09ｨｪ06ｨｦ ｨｨ 0907060906ｨ ｨｪｨ 0702080201ｨ 09ｨ ｨｰｨｹ 09ｨｨ00ｨｪｨ 05 09 ｨｺ0502ｨｰｨｺｨｮ. 08ｨｺｨｰｨｨ09ｨ 02ｨｨ07 000608ｨｬ06ｨｪ06ｨｬ 050207ｨｰｨｨｨｪ0609060006 0802020207ｨｰ0608ｨ 0708ｨｨ090601ｨｨｨｰ ｨｺ 09ｨｰｨｨｨｬｨｮ050702ｨｨｨｨ ｨｪ020802020207ｨｰ0608ｨｪ06ｨｦ ｨｰｨｨ080604ｨｨｨｪｨｺｨｨｨｪｨ 0404 JAK2, ｨｺ06ｨｰ0608ｨ 07 000609000608ｨｨ05ｨｨ08ｨｮ02ｨｰ 09ｨｪｨｮｨｰ08ｨｨｨｺ0502ｨｰ06 ﾂｨｪ04ｨｦ 0106ｨｬ02ｨｪ 0802020207ｨｰ0608ｨ ｨｨ 06ｨ 02090702 ﾂｨｨ09ｨ 02ｨｰ 020006 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0602 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ02 09 IRS-ｨ 0205ｨｺｨ ｨｬｨｨ ｨｨ 01ｨ 05ｨｹｨｪ02ｨｦ03ｨｮ06 ｨ ｨｺｨｰｨｨ09ｨ 02ｨｨ06 PI3K ｨｨ ｨｺｨ 09ｨｺｨ 01ｨ ｨｬｨｨｨｰ060002ｨｪｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ02ｨｬ0401 070806ｨｰ02ｨｨｨｪｨｺｨｨｨｪｨ 04 (Hegyi et al., 2004). 06ｨｨ080604ｨｨｨｪｨｺｨｨｨｪｨ 04ｨ JAK2 ｨｰｨ ｨｺ0302 ｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ02ｨｰ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪ04ｨｦ 00ｨ ｨｺｨｰ0608 STAT3, ｨｺ06ｨｰ060804ｨｦ 0706090502 000609000608ｨｨ05ｨｨ080609ｨ ｨｪｨｨ07 07060109020800ｨ 02ｨｰ0907 0006ｨｬ0601ｨｨｨｬ0208ｨｨ04ｨ 02ｨｨｨｨ, ｨｰ08ｨ ｨｪ09050602ｨｨ08ｨｮ02ｨｰ0907 09 07010806 ｨｨ 080200ｨｮ05ｨｨ08ｨｮ02ｨｰ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ STAT3-04ｨ 09ｨｨ09ｨｨｨｬ0401 0002ｨｪ0609 (Mutze et al., 2006; Sahu et al., 2011) (08ｨｨ09. 2). 030609ｨｺ0605ｨｹｨｺｨｮ IRS-ｨ 0205ｨｺｨｨ ｨｨ ｨｪｨｨ0302050203ｨ ｨｴｨｨｨｦ 3-0006090006ｨｨｨｪ0604ｨｨｨｰｨｨ01ｨｪ04ｨｦ ｨｺｨ 09ｨｺｨ 01 0709050706ｨｰ0907 09ｨ 03ｨｪ02ｨｦ03ｨｨｨｬｨｨ ｨ 0506ｨｺｨ ｨｬｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ0609060006 ｨｨ 060804-1 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ09ｨｰ02ｨｬ, 06ｨｪｨｨ ｨｨ 06ｨ 02090702 ﾂｨｨ09ｨ 06ｨｰ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0602 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｨ02 ｨｬ020301ｨｮ ｨｪｨｨｨｬｨｨ ｨｨ 050207ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ06ｨｦ ｨｺｨ ｨｺ 09 ｨｪ0608ｨｬ02, ｨｰｨ ｨｺ ｨｨ 09 ｨｮ09050609ｨｨ0701 01ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 07ｨ ｨｰ06050600ｨｨｨｨ. 090207ｨｰｨｨｨｪ ｨｬ060400ｨ 0904ｨ ｨｨｨｬ060102ｨｦ09ｨｰ09ｨｮ02ｨｰ 0906 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨ ｨｬｨｨ 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｮ09ｨ ｨｨ 080200ｨｮ05ｨｨ08ｨｮ02ｨｰ 08ｨ 09010601 05ｨｪ020800ｨｨｨｨ ｨｨ 0706ｨｰ0802ｨ 0502ｨｪｨｨ02 07ｨｨｨｴｨｨ, 0609ｨｮｨｴ0209ｨｰ09050707 ｨｺ06ｨｪｨｰ080605ｨｹ 09ｨｨｨｪｨｰ0204ｨ ｨｨ 0902ｨｺ080202ｨｨｨｨ ｨｪ02ｨｦ0806070207ｨｰｨｨ01ｨ Y, ｨ ｨｰｨ ｨｺ0302 a-ｨｬ0205ｨ ｨｪ0602ｨｨｨｰ09ｨｰｨｨｨｬｨｮ05ｨｨ08ｨｮ06ｨｴ020006 000608ｨｬ06ｨｪｨ (a-000501) ｨｨ ｨ 00ｨｮｨｰｨｨ-07060106ｨ ｨｪ060006 070207ｨｰｨｨ01ｨ 090606ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06 ｨ 0006ｨｪｨｨ09ｨｰｨ ｨｨ ｨ ｨｪｨｰｨ 0006ｨｪｨｨ09ｨｰｨ ｨｬ0205ｨ ｨｪ06ｨｺ0608ｨｰｨｨｨｪ06090401 0802020207ｨｰ06080609 3-0006 ｨｨ 4-0006 ｨｰｨｨ070609 (Schwartz et al., 2000; Signore et al., 2008; Williams et al., 2011). 01ｨ 08ｨｮ0302ｨｪｨｨ02 05ｨｰ060006 ｨｺ06ｨｪｨｰ08060507 0708ｨｨ090601ｨｨｨｰ ｨｺ 00ｨｨ07020800ｨ 00ｨｨｨｨ, 0603ｨｨ0802ｨｪｨｨ06 ｨｨ 08ｨ 0409ｨｨｨｰｨｨ06 0708020101ｨｨｨ ｨ 02ｨｰｨｨ ﾂ0209ｨｺｨｨ01 090609ｨｰ0607ｨｪｨｨｨｦ. 090207ｨｰｨｨｨｪ, ｨｺｨ ｨｺ ｨｨ ｨｨｨｪ09ｨｮ05ｨｨｨｪ, 080200ｨｮ05ｨｨ08ｨｮ02ｨｰ 090604ｨ ｨｮ01ｨｨｨｬ0609ｨｰｨｹ 00ｨｨ0706ｨｰｨ 05ｨ ｨｬｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ02ｨｦ0806ｨｪ0609, ｨｬ0601ｨｮ05ｨｨ08ｨｮ02ｨｰ 09ｨｨｨｪｨ 07ｨｰｨｨ ﾂ0209ｨｺｨｮ06 0705ｨ 09ｨｰｨｨ ﾂｨｪ0609ｨｰｨｹ, ｨｮ ﾂｨ 09ｨｰ09ｨｮ02ｨｰ 09 07080602020909ｨ 01 06ｨ ｨｮ ﾂ02ｨｪｨｨ07 ｨｨ 000608ｨｬｨｨ080609ｨ ｨｪｨｨ07 07ｨ ｨｬ07ｨｰｨｨ. 02ｨｪ 06ｨ 050200 ﾂｨ 02ｨｰ 07080209ｨｨｨｪｨ 07ｨｰｨｨ ﾂ0209ｨｺ0602 0904090906ｨ 06030102ｨｪｨｨ02 ｨｪ02ｨｦ0806ｨｰ08ｨ ｨｪ09ｨｬｨｨｨｰｨｰ02080609 ｨｨ 0706090403ｨ 02ｨｰ 070609ｨｰ09ｨｨｨｪｨ 07ｨｰｨｨ ﾂ0209ｨｺｨｮ06 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ ｨｺ ｨｪｨｨｨｬ 09 ｨｪ02ｨｦ0806ｨｪｨ 01 00ｨｨ070706ｨｺｨ ｨｬ07ｨ, ｨ ｨｰｨ ｨｺ0302 080200ｨｮ05ｨｨ08ｨｮ02ｨｰ 00ｨｨ070706ｨｺｨ ｨｬ07ｨ 05ｨｹｨｪｨｮ06 09ｨｨｨｪｨ 07ｨｰｨｨ ﾂ0209ｨｺｨｮ06 0705ｨ 09ｨｰｨｨ ﾂｨｪ0609ｨｰｨｹ. 01080404ｨｮｨｪ04 09 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07ｨｬｨｨ 09 050207ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ02 0102ｨｬ06ｨｪ09ｨｰ08ｨｨ08ｨｮ06ｨｰ 09ｨｪｨｨ0302ｨｪｨｨ02 00ｨｨ070706ｨｺｨ ｨｬ07ｨ 05ｨｹｨｪ06ｨｦ 09ｨｨｨｪｨ 07ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 0705ｨ 09ｨｰｨｨ ﾂｨｪ0609ｨｰｨｨ, 0708ｨｨ ﾂ02ｨｬ 06ｨ 08ｨ ｨ 06ｨｰｨｺｨ 050207ｨｰｨｨｨｪ06ｨｬ 070605ｨｪ0609ｨｰｨｹ06 09060909ｨｰｨ ｨｪｨ 0905ｨｨ09ｨ 02ｨｰ 00ｨｮｨｪｨｺ02ｨｨｨｨ 00ｨｨ070706ｨｺｨ ｨｬ07ｨ (Li et al., 2002). 030609020102ｨｪ ﾂ0209ｨｺｨｨ02 05ｨｺ09070208ｨｨｨｬ02ｨｪｨｰ04 0706ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ06 09 ｨｪｨｨ04ｨｺｨｨ01 00ｨｨ04ｨｨ06050600ｨｨ ﾂ0209ｨｺｨｨ01 010604ｨ 01 050207ｨｰｨｨｨｪ ｨｮ05ｨｮ ﾂ03ｨ 02ｨｰ 07080609ｨｰ08ｨ ｨｪ09ｨｰ0902ｨｪｨｪ0602 06ｨ ｨｮ ﾂ02ｨｪｨｨ02 ｨｨ 0106050006090802ｨｬ02ｨｪｨｪ0602 0706ｨｰ02ｨｪ02ｨｨ080609ｨ ｨｪｨｨ02, 09 ｨｰ06 090802ｨｬ07 ｨｺｨ ｨｺ 09040906ｨｺｨｨ02 01060404 000608ｨｬ06ｨｪｨ, ｨｪｨ 070806ｨｰｨｨ09, ｨｮ01ｨｮ0103ｨ 06ｨｰ 05ｨｰｨｨ 0706ｨｺｨ 04ｨ ｨｰ0205ｨｨ (Oomura et al., 2011). 090207ｨｰｨｨｨｪ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨｨ08ｨｮ02ｨｰ 09 ｨｪ02ｨｦ0806ｨｪｨ 01, ｨｺｨ ｨｺ ｨ ｨｪｨｰｨｨｨ 070607ｨｰ06ｨｰｨｨ ﾂ0209ｨｺｨｨｨｦ 00ｨ ｨｺｨｰ0608, ｨｨ 020006 0102ｨｦ09ｨｰ09ｨｨ02 0802ｨ 05ｨｨ04ｨｮ02ｨｰ0907 0706 ｨｪ0209ｨｺ0605ｨｹｨｺｨｨｨｬ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ04ｨｬ 07ｨｮｨｰ07ｨｬ, 060708020102050706ｨｴｨｮ06 080605ｨｹ 09080201ｨｨ ｨｺ06ｨｰ06080401 ｨｨ0008ｨ 02ｨｰ 3-0006090006ｨｨｨｪ0604ｨｨｨｰｨｨ01ｨｪ04ｨｦ 07ｨｮｨｰｨｹ, 09ｨｺ0506 ﾂｨ 06ｨｴｨｨｨｦ 09 0902ｨ 07 PI3K ｨｨ AKT-ｨｺｨｨｨｪｨ 04ｨｮ (Morton et al., 2005) (08ｨｨ09. 2). 090207ｨｰｨｨｨｪ ｨｰｨ ｨｺ0302 0709050702ｨｰ0907 ｨｪ02ｨｦ0806ｨｰ080600ｨｨ ﾂ0209ｨｺｨｨｨｬ 00ｨ ｨｺｨｰ060806ｨｬ, ｨｪｨ ﾂｨｰ06 ｨｮｨｺｨ 040409ｨ 02ｨｰ 020006 0907060906ｨ ｨｪ0609ｨｰｨｹ 0708020106ｨｰ0908ｨ ｨｴｨ ｨｰｨｹ 01020008ｨ 01ｨ 02ｨｨ06 010600ｨ ｨｬｨｨｨｪ020800ｨｨ ﾂ0209ｨｺｨｨ01 ｨｪ02ｨｦ0806ｨｪ0609, 09040409ｨ ｨｪｨｪｨｮ06 0102ｨｦ09ｨｰ09ｨｨ02ｨｬ ｨｰ06ｨｺ09ｨｨｨｪ0609, ｨｨ 09060909ｨｰｨ ｨｪｨ 0905ｨｨ09ｨ ｨｰｨｹ 070609020102ｨｪ ﾂ0209ｨｺｨｨ02 0802ｨ ｨｺ02ｨｨｨｨ, ｨｪｨ 08ｨｮ0302ｨｪｨｪ0402 09 ｨｮ09050609ｨｨ0701 ｨｨｨｪｨｰ06ｨｺ09ｨｨｨｺｨ 02ｨｨｨｨ (Weng et al., 2007). 050502010609ｨ ｨｰ0205ｨｹｨｪ06, 050207ｨｰｨｨｨｪ ｨｪ02 ｨｰ0605ｨｹｨｺ06 04ｨ ｨｴｨｨｨｴｨ 02ｨｰ ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ 06ｨｰ ｨｰ06ｨｺ09ｨｨ ﾂｨｪ0609ｨｰｨｨ, ｨｪ06 ｨｨ 0708020106ｨｰ0908ｨ ｨｴｨ 02ｨｰ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 09 09ｨｨ00ｨｪｨ 05ｨｹｨｪ0401 09ｨｨ09ｨｰ02ｨｬｨ 01 ｨｬ060400ｨ, 080200ｨｮ05ｨｨ08ｨｮ02ｨｬ0401 010600ｨ ｨｬｨｨｨｪ06ｨｬ ｨｨ 0108ｨｮ00ｨｨｨｬｨｨ ｨｪ02ｨｦ0806ｨｬ0201ｨｨｨ ｨｰ0608ｨ ｨｬｨｨ, ﾂｨｰ06 ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ ｨｨ09070605ｨｹ040609ｨ ｨｪ06 010507 07080201ｨｮ070802030102ｨｪｨｨ07 08ｨ 0409ｨｨｨｰｨｨ07 ｨｪ02ｨｦ080601020002ｨｪ0208ｨ ｨｰｨｨ09ｨｪ0401 070806020209090609 09 ｨｮ09050609ｨｨ0701 0708020101ｨｨｨ ｨ 02ｨｰｨ ｨｨ 05022. 0306ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 ｨｮ ｨｺ080409 Zucker fa/fa ｨｨ ｨｬ040302ｨｦ db/db 09010200ｨｨ02ｨｨｨｰ06ｨｬ 050207ｨｰｨｨｨｪ0609060006 0802020207ｨｰ0608ｨ ｨｨｨｬ0206ｨｰ0907 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 070806020209090609 00ｨｨ070706ｨｺｨ ｨｬ07ｨ 05ｨｹｨｪ06ｨｦ 0106050006090802ｨｬ02ｨｪｨｪ06ｨｦ 0706ｨｰ02ｨｪ02ｨｨｨ 02ｨｨｨｨ ｨｨ 08ｨ 0409ｨｨｨｰｨｨ02 0105ｨｨｨｰ0205ｨｹｨｪ06ｨｦ 01020708020909ｨｨｨｨ (Li et al., 2002; Ramos-Rodriguez et al., 2014). 07 ｨｪｨｨ01 090407090502ｨｪｨ ｨｪ02010609ｨｰｨ ｨｰ06 ﾂｨｪ0609ｨｰｨｹ ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ06ｨｦ ｨｨ 070609020102ｨｪ ﾂ0209ｨｺ06ｨｦ 0705ｨ 09ｨｰｨｨ ﾂｨｪ0609ｨｰｨｨ, 0708ｨｨ- ﾂ02ｨｬ 0909020102ｨｪｨｨ02 050207ｨｰｨｨｨｪｨ ｨｪ02 ｨｮ09ｨｰ08ｨ ｨｪ0702ｨｰ 05ｨｰｨｨ ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 090905020109ｨｰ09ｨｨ02 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨ07 0902ｨｪ090608ｨｪ060006 ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰｨ 050207ｨｰｨｨｨｪ060906ｨｦ 09ｨｨ00ｨｪｨ 05ｨｹｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04. 00 ｨｮ09050609ｨｨ0701 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨ07 09ｨ ｨｬ060006 050207ｨｰｨｨｨｪｨ ｨｮ ｨｬｨｮｨｰｨ ｨｪｨｰｨｪ0401 Lep ob/ob -ｨｬ040302ｨｦ 09 0603ｨｨ0802ｨｪｨｨ02ｨｬ 09ｨｪｨｨ03ｨ 02ｨｰ0907 ｨｺｨ ｨｺ 090601020803ｨ ｨｪｨｨ02 010600ｨ ｨｬｨｨｨｪｨ 09 090204ｨｨｨｺｨｮ05ｨ 01 ｨｪ02ｨｦ0806ｨｪｨ 05ｨｹｨｪ0401 ｨｺ0502ｨｰ06ｨｺ, ｨｰｨ ｨｺ ｨｨ ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 0904090906ｨ 060301ｨ 02ｨｬ060006 ｨｨ04 ｨｪｨｨ01 ｨｪ02ｨｦ0806ｨｬ0201ｨｨｨ ｨｰ0608ｨ (Roseberry et al., 2007). 06ｨｰ06 09090704ｨ ｨｪ06 09 ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02ｨｬ ﾂｨｨ0905ｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06 ｨ ｨｺｨｰｨｨ09ｨｪ0401 ｨｰ08ｨ ｨｪ09070608ｨｰ02080609 010600ｨ ｨｬｨｨｨｪｨ, ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ06ｨｴｨｨ01 ｨｮ08060902ｨｪｨｹ 010600ｨ ｨｬｨｨｨｪｨ 09 09ｨｨｨｪｨ 07ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｴ0205ｨｨ. 06ｨｪｨｰ08ｨ 02020802ｨ 08ｨ 05ｨｹｨｪ0602 0909020102ｨｪｨｨ02 050207ｨｰｨｨｨｪｨ MCR-ｨｬ0403ｨ ｨｬ, ｨｺ06ｨｰ06080402 ｨｨｨｬ0206ｨｰ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06 ｨｪ02ｨ ｨｺｨｰｨｨ09ｨｪ04ｨｦ 060804104 09 09ｨｺ020502ｨｰｨｪ0401 ｨｬ040302ｨ 01 ｨｨ 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ04ｨｮ06ｨｰ0907 00ｨｨ0702080005ｨｨｨｺ02ｨｬｨｨ02ｨｦ, 00ｨｨ070208ｨｨｨｪ09ｨｮ05ｨｨｨｪ02ｨｬｨｨ02ｨｦ ｨｨ 01ｨｨ0905ｨｨ07ｨｨ0102ｨｬｨｨ02ｨｦ,