130005ｨｨ07ｨｪｨｨ02 0002ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ01 00ｨ ｨｺｨｰ06080609 ﾂ0205060902ｨｺｨ ｨｪｨ 09040906ｨｺ06ｨ ｨｺｨｰｨｨ09ｨｪｨｮ06 ｨ ｨｪｨｰｨｨ0802ｨｰ080609ｨｨ08ｨｮ09ｨｪｨｮ06 ｨｰ0208ｨ 07ｨｨ06 (0008080406)* 06ｨｮ ｨｬｨ ｨｪ0609 08.05. 08010907 00010606 09ｨｨ08ｨｮ0906050600ｨｨｨｨ ｨｨｨｬ. 02.06. 0609ｨ ｨｪ060909ｨｺ06000603 0005 0408, 123098, 0006 09ｨｺ 09ｨ, ｨｮ05. 01ｨ ｨｬｨ 0502ｨｨ,16, ｨｰ0205./00ｨ ｨｺ09: 8-499-190-30-63, e-ma il: de sep@ma il.ru 0604ｨｮ ﾂ02ｨｪｨｨ02 0002ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ01 00ｨ ｨｺｨｰ06080609 ﾂ0205060902ｨｺｨ, ｨ 09090602ｨｨｨｨ080609ｨ ｨｪｨｪ0401 09 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 0502 ﾂ02ｨｪｨｨ07 0006 ﾁ-ｨｨｨｪ0002ｨｺ02ｨｨｨｨ, 0709050702ｨｰ0907 09ｨ 03 - ｨｪ04ｨｬ ｨｪｨ 0708ｨ 090502ｨｪｨｨ02ｨｬ 09 ｨ 0608ｨｹｨ 02 09 ｨｪ0206 ｨｨ 0503060206ｨｬ. 05ｨ 070609050201ｨｪｨｨ02 0109ｨ 01020907ｨｰｨｨ0502ｨｰｨｨ07 ｨ 040506 06ｨ ｨｪｨ 08ｨｮ0302ｨｪ06 ｨｬｨｪ060006 ｨ 09090602ｨｨｨ 02ｨｨｨｦ ｨｬ020301ｨｮ 08ｨ 0405ｨｨ ﾂｨｪ04ｨｬｨｨ ｨ 05050205ｨｹｨｪ04ｨｬｨｨ 09ｨ 08ｨｨｨ ｨｪｨｰｨ ｨｬｨｨ 0002ｨｪ0609 ﾂ0205060902ｨｺｨ ｨｨ 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 ｨ ｨｪｨｰｨｨ0802ｨｰ080609ｨｨ08ｨｮ09ｨｪ06ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ (080406) 0006 ﾁ-ｨｨｨｪ0002ｨｺ02ｨｨｨｨ. 020906ｨ 02ｨｪｨｪ04ｨｦ ｨｨｨｪｨｰ02080209 010507 ｨｨ09090502010609ｨ ｨｰ020502ｨｦ 0708020109ｨｰｨ 09050706ｨｰ ｨ 05050205ｨｹｨｪ0402 09ｨ 08ｨｨｨ ｨｪｨｰ04 0002ｨｪ0609, ｨ 09090602ｨｨｨｨ080609ｨ ｨｪｨｪ0402 09 ｨｰ0703000504ｨｬｨｨ 0609050603ｨｪ02ｨｪｨｨ07ｨｬｨｨ, 090604ｨｪｨｨｨｺｨ 06ｨｴｨｨｨｬｨｨ 0708ｨｨ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨｨｨ 080406. 00ｨｪ0600ｨｨ02 ｨｨ04 ｨｨ04ｨｮ ﾂ02ｨｪｨｪ0401 ｨ 09090602ｨｨｨ 02ｨｨｨｦ ｨｰ0802ｨ ｨｮ06ｨｰ 07080609020102ｨｪｨｨ07 070601ｨｰ0902080301ｨ 06ｨｴｨｨ01 ｨｨ ｨｮｨｰ06 ﾂ - ｨｪ0706ｨｴｨｨ01 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ. 00 01ｨ ｨｪｨｪ06ｨｦ 09ｨｰｨ ｨｰｨｹ02 07080609020100ｨｪ 06ｨ 040608 0002ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ01 00ｨ ｨｺｨｰ06080609, 01ｨ 06ｨｴｨｨｨｦ ｨｺ0506 ﾂ ｨｺ 0706ｨｪｨｨｨｬｨ ｨｪｨｨ06 090604ｨｬ0603ｨｪ0609ｨｰｨｨ 0706-09040302ｨｪｨｨ07 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 080406 010507 0006 ﾁ-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 07ｨ 02ｨｨ02ｨｪｨｰ0609. 080506 ﾂ02090402 09050609ｨ : 0006 ﾁ-ｨｨｨｪ0002ｨｺ02ｨｨ07, 0002ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨ02 00ｨ ｨｺｨｰ060804 01060407ｨｨｨｪｨ, 09040906ｨｺ06ｨ ｨｺｨｰｨｨ09ｨｪｨ 07 ｨ ｨｪｨｰｨｨ0802ｨｰ080609ｨｨ08ｨｮ09ｨｪｨ 07 ｨｰ0208ｨ 07ｨｨ07 0009020102ｨｪｨｨ02 00ｨｪ02010800ｨｪｨｪｨ 07 09 ｨｬ02 01ｨｨ 02ｨｨｨｪ 09ｨｺｨｮ06 0708ｨ ｨｺ ｨｰｨｨ ｨｺｨｮ 06ｨｺ06 0506 25 0502ｨｰ ｨｪｨ 04ｨ 01 080406 ｨｪｨ 070208 090401 05ｨｰｨ 07ｨ 01 06ｨｺｨ 04ｨ 05ｨ 09ｨｹ ｨｪ02 0106 09ｨｰｨ ｨｰ06 ﾂ ｨｪ06 0500-0002ｨｺ ｨｰｨｨ09 ｨｪ04ｨｬ ｨｨｨｪ 09ｨｰ 08ｨｮ ｨｬ02ｨｪ ｨｰ06ｨｬ 09 ｨ 06 08ｨｹ ｨ 02 09 0006 ﾁ-ｨｨｨｪ 0002ｨｺ 02ｨｨ02ｨｦ ｨｨ 050306 0206ｨｬ, 0601 ｨｪｨ ｨｺ06 0706 090502 01ｨｮ 06 ｨｴ0202 0706 0709 0502 ｨｪｨｨ02 0904 0906 ｨｺ06 ｨ ｨｺ - ｨｰｨｨ09ｨｪ06ｨｦ ｨ ｨｪｨｰｨｨ0802ｨｰ080609ｨｨ08ｨｮ09ｨｪ06ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ (0008080406) 070604090605ｨｨ0506 09ｨｮ ｨｴ02 09ｨｰ 0902ｨｪ ｨｪ06 0706 0904 09ｨｨｨｰｨｹ 0102ｨｦ 09ｨｰ 0902ｨｪ ｨｪ0609ｨｰｨｹ 0502 ﾂ02 ｨｪｨｨ07 0006 ﾁ-ｨｨｨｪ - 00ｨｨ 02ｨｨ 0806 09ｨ ｨｪ ｨｪ0401 05ｨｨ02, ｨｮ0902 05ｨｨ ﾂｨｨｨｰｨｹ 070806 010605 03ｨｨ ｨｰ02 05ｨｹ ｨｪ0609ｨｰｨｹ ｨｨ 0706090409ｨｨｨｰｨｹ ｨｺｨ ﾂ0209ｨｰ0906 ｨｨ01 03ｨｨ04ｨｪｨｨ. 0609070605ｨｹ040609ｨ ｨｪｨｨ02 0008080406 0708ｨｨ09020506 ｨｺ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ06 ﾂｨｨ0905ｨ ｨｪｨ ｨｮ ﾂｨｪ0401 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ 0706 070609040302ｨｪｨｨ06 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 0200 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ07, ﾂｨｰ06, 09 09090606 06 ﾂ02080201ｨｹ, 070604090605ｨｨ0506 06ｨ ｨｪｨ 08ｨｮ03ｨｨｨｰｨｹ 0601ｨｨｨｪ ｨｨ04 09ｨ 03ｨｪ02ｨｦ03ｨｨ01 00ｨ ｨｺｨｰ06080609, 06ｨｺｨ 040409ｨ 06ｨｴｨｨ01 0905ｨｨ07ｨｪｨｨ02 ｨｪｨ 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 0008080406 09 ｨ 0608ｨｹｨ 02 09 0006 ﾁ-ｨｨｨｪ0002ｨｺ02ｨｨ02ｨｦ ｨｨ 0503060206ｨｬ, ｪ 0002ｨｪ06ｨｬ ﾂ0205060902ｨｺｨ. 0306ｨｨ09ｨｺ ｨ 05050205ｨｹｨｪ0401 09ｨ 08ｨｨｨ ｨｪｨｰ0609 0002ｨｪ0609 ﾂ0205060902ｨｺｨ, ｨ 09090602ｨｨｨｨ080609ｨ ｨｪｨｪ0401 09 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 0008080406, 0709050702ｨｰ0907 ｨｪｨ 01ｨ ｨｪｨｪ04ｨｦ ｨｬ06ｨｬ02ｨｪｨｰ 090802ｨｬ02ｨｪｨｨ 0601ｨｪｨｨｨｬ ｨｨ04 09ｨ 03ｨｪ02ｨｦ03ｨｨ01 ｨｪｨ 0708ｨ 090502ｨｪｨｨｨｦ ｨｪｨ ｨｮ ﾂｨｪ0401 ｨｨ040409ｨｺｨ ｨｪｨｨｨｦ 09 0900020802 ｨ 0608ｨｹｨ 04 09 0006 ﾁ-ｨｨｨｪ 0002ｨｺ 02ｨｨ02ｨｦ ｨｨ 050306 0206ｨｬ. 00 01ｨ ｨｪ ｨｪ06ｨｦ 09ｨｰｨ ｨｰｨｹ02 05ｨｰ06 ｨｨ ｨｪｨ 030506 09090600 06ｨｰ08ｨ 0302ｨｪｨｨ02 09 09ｨｨ0102 ｨｪ02ｨ 0605ｨｹ03060006 06ｨ 040608ｨ 0706 0002ｨｪ02ｨｰｨｨ ﾂ0209ｨｺｨｨｨｬ 00ｨ ｨｺｨｰ0608ｨ ｨｬ ﾂ0205060902ｨｺｨ, ｨ 09090602ｨｨｨｨ080609ｨ ｨｪｨｪ04ｨｬ 09 0008080406. 06000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨ ｨｪｨｰｨｨ0802ｨｰ080609ｨｨ08ｨｮ09ｨｪ0401 07080207ｨ 08ｨ ｨｰ0609 05 ｨｺｨ 030104ｨｬ 00060106ｨｬ 09 ｨｬｨｨ0802 070806090601ｨｨｨｰ0907 090900 ｨ 0605ｨｹ0302 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ, 0706090907ｨｴ00ｨｪｨｪ0401 0905ｨｨ07ｨｪｨｨ06 060906ｨ 02ｨｪｨｪ0609ｨｰ02ｨｦ 0002ｨｪ06 - ｨｬｨ ﾂ0205060902ｨｺｨ ｨｪｨ ｨｮ09070203ｨｪ0609ｨｰｨｹ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 080406. 020906ｨ 02ｨｪ - ｨｪ04ｨｦ ｨｨｨｪ ｨｰ02 080209 010507 ｨｨ09 090502 0106 09ｨ ｨｰ02 0502ｨｦ 07080201 09ｨｰｨ 09 0507 02ｨｰ 0905ｨｨ 07 ｨｪｨｨ02 0002 ｨｪ02 ｨｰｨｨ ﾂ02 09ｨｺｨｨ01 00ｨ ｨｺ ｨｰ06 080609 ﾂ0205060902ｨｺｨ ｨｪｨ 0500 0002ｨｺ ｨｰｨｨ09 ｨｪ0609ｨｰｨｹ 0708ｨｨ - ｨｬ02 ｨｪ02 ｨｪｨｨ07 08ｨ 04 ｨｪ0401 0008ｨｮ0707 ｨ ｨｪ ｨｰｨｨ 0802ｨｰ 0806 09ｨｨ 08ｨｮ09 ｨｪ0401 070802 07ｨ 08ｨ ｨｰ0609 ｨｨ 090604ｨｪｨｨｨｺｨｪ060902ｨｪｨｨ02 0708ｨｨ 05ｨｰ06ｨｬ 08ｨ 04ｨｪ0606ｨ 08ｨ 04ｨｪ0401 0609050603ｨｪ02ｨｪｨｨｨｦ ｨｮ 0006 ﾁ-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 07ｨ 02ｨｨ02ｨｪｨｰ0609. 08 ｨｰｨ ｨｺｨｨｨｬ 0002 ｨｪ02 ｨｰｨｨ ﾂ02 09ｨｺｨｨｨｬ 00ｨ ｨｺ ｨｰ0608ｨ ｨｬ 06ｨｰｨｪ060907 ｨｰ 0907 ｨｬ02 ｨｰｨ ｨ 06-05ｨｨ ﾂ02 09ｨｺｨｨ02 000208 ｨｬ02ｨｪ ｨｰ04. 0601 0708 ｨｺｨｨｨｬ 06ｨ 08ｨ 04 0206ｨｬ 0905ｨｮ03ｨｨｨｰ ｨ 06 05ｨｹ - 03ｨ 07 0008ｨｮ07 07ｨ 000208 ｨｬ02ｨｪ ｨｰ0609 09ｨｮ 070208 0902 ｨｬ02ｨｦ 09ｨｰ 09ｨ 02ｨｨ ｨｰ06 010806 ｨｬ0609 P450 (cytochrome P450, CYP450), 0609ｨｪ0609ｨｪ06ｨｦ 00ｨｮｨｪｨｺ02ｨｨ02ｨｦ ｨｺ06ｨｰ06-080401 0709050702ｨｰ0907 ｨｺｨ ｨｰｨ 05ｨｨ04 06ｨｺｨｨ090502ｨｪｨｨ07 060800ｨ ｨｪｨｨ ﾂ0209ｨｺｨｨ01 09ｨｮｨ 09ｨｰｨ ｨｪ02ｨｨｨｦ. 0906 05ｨｹ 03ｨ 07 ﾂｨ 09ｨｰｨｹ 0902 ｨｬ02ｨｦ 09ｨｰ 09ｨ CYP450 0906 090502 ﾂ02ｨｪｨ 09 ｨｬ02 ｨｰｨ - ｨ 06 05ｨｨ04ｨｬ ｨｨ ｨ ｨｨ06 ｨ ｨｺ ｨｰｨｨ 09ｨ 02ｨｨ06 0502 ｨｺｨ 08 09ｨｰ 0902ｨｪ ｨｪ0401 070802 07ｨ 08ｨ ｨｰ0609, ｨｮ ﾂｨ 09ｨｰ 09ｨｮ07 09 75% 06ｨ ｨｴ02 0006 ﾂｨｨ09 05ｨ 08ｨ 04 05ｨｨ ﾂ ｨｪ0401 ｨｬ02 ｨｰｨ ｨ 06 05ｨｨ ﾂ02 09ｨｺｨｨ01 0802 ｨ ｨｺ 02ｨｨｨｦ, 0708ｨｨ 05ｨｰ06ｨｬ, ｨｺｨ ｨｺ 0708ｨ 09ｨｨ 0506, ﾂ02ｨｬ 09ｨｨ 05ｨｹ ｨｪ0202 05ｨｺ 09 07 080209-09ｨｨ07 01ｨ ｨｪ ｨｪ0401 000208 ｨｬ02ｨｪ ｨｰ0609, ｨｰ02ｨｬ ｨｪｨｨ 0302 ｨｺ06ｨｪ 0202ｨｪ ｨｰ 08ｨ 02ｨｨ07 0502 ｨｺｨ 08-09ｨｰ 0902ｨｪ ｨｪ0401 070802 07ｨ 08ｨ ｨｰ0609 09 ｨｺ0502ｨｰ ｨｺ02, ｨｨ ｨｪｨ 06 ｨ 06 0806ｨｰ. 0308ｨｨ ｨｬ02 ｨｪｨｨ ｨｰ02 05ｨｹ ｨｪ06 ｨｺ 080406 06ｨ ｨｲ 02ｨｺ ｨｰ06ｨｬ 0905ｨｨ 07 ｨｪｨｨ07 01ｨ ｨｪ ｨｪ06ｨｦ 0008ｨｮ07 0704 0709 0507 02ｨｰ 0907 0906 010208 03ｨ ｨｪｨｨ02 070802 07ｨ 08ｨ ｨｰ0609 080406 09 ｨｺ0502ｨｰ ｨｺｨ 01, 07080601ｨｮ02ｨｨ08ｨｮ06ｨｴｨｨ01 0006 ﾁ. 07 07ｨ 02ｨｨ02ｨｪｨｰ0609, ｨｨｨｬ0206ｨｴｨｨ01 ｨｪｨｨ04ｨｺｨｮ06 05ｨｺ090708020909ｨｨ06 ｨｨ05ｨｨ ｨｪ02010609ｨｰｨ ｨｰ06ｨｺ ﾂｨ 09ｨｰｨｨ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨ01 000208 - ｨｬ02ｨｪ ｨｰ0609, ｨｪｨ ｨ 0506 01ｨ 02ｨｰ 0907 0904 0906 ｨｺｨ 07 0705ｨ 04 ｨｬｨ ｨｰｨｨ ﾂ02 09ｨｺｨ 07 ｨｺ06ｨｪ 0202ｨｪ ｨｰ - 08ｨ 02ｨｨ07 0502 ｨｺｨ 08 09ｨｰ 0902ｨｪ ｨｪ0401 070802 07ｨ 08ｨ ｨｰ0609, ｨｺ06 ｨｰ06 08ｨ 07, 09 09090606 06 ﾂ02-080201ｨｹ, ｨｬ06 0302ｨｰ 0904 0409ｨ ｨｰｨｹ ｨｰ06ｨｺ09ｨｨ ﾂ ｨｪ0609ｨｰｨｹ. 01ｨ 070806 ｨｰｨｨ09, 0708ｨｨ 0905ｨｨ03 - ｨｺ06ｨｬ 0904 0906 ｨｺ06ｨｦ ｨ ｨｺ ｨｰｨｨ09 ｨｪ06 09ｨｰｨｨ 000208 ｨｬ02ｨｪ ｨｰ0609 0008ｨｮ07 0704 CYP450 ｨｺ06ｨｪ 0202ｨｪ ｨｰ 08ｨ 02ｨｨ07 0502 ｨｺｨ 08 09ｨｰ 0902ｨｪ ｨｪ0401 070802 07ｨ 08ｨ ｨｰ0609 ｨｪ02 0106 09ｨｰｨｨ 00ｨ 02ｨｰ ｨｮ080609ｨｪ07 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ, 010609ｨｰｨ ｨｰ06 ﾂｨｪ06ｨｦ 010507 ｨｨｨｪ00ｨｨｨ ｨｨ080609ｨ - ｨｪｨｨ07 09ｨｨ08ｨｮ09ｨ. 06ｨ ｨｺ, ｨｮ09ｨｰｨ ｨｪ0609 0502 ｨｪ06, ﾂｨｰ06 ｨｨ0406 000208 ｨｬ02ｨｪｨｰ CYP2D6 ｨｬ02 ｨｰｨ ｨ 06-05ｨｨ 04ｨｨ 08ｨｮ 02ｨｰ ｨ 06 05ｨｹ 03ｨｮ06 ﾂｨ 09ｨｰｨｹ ｨ ｨｪ ｨｰｨｨ 0802ｨｰ 0806 09ｨｨ 08ｨｮ09 ｨｪ0401 070802 07ｨ 08ｨ - ｨｰ0609. 0805 0502 05ｨｹ ｨｪ0402 09ｨ 08ｨｨ ｨ ｨｪ ｨｰ04 CYP2D6*9, CYP2D6*10 ｨｨ CYP2D6*17 ｨ 09090602ｨｨｨｨ080609ｨ ｨｪ04 09 ｨｨｨｪ00ｨｨｨ ｨｨ080609ｨ ｨｪｨｨ02ｨｬ ｨｨ0406000208ｨｬ02ｨｪ ｨｰｨ CYP2D6, 09 ｨｰ06 090802ｨｬ07 ｨｺｨ ｨｺ 0708ｨｨ 09ｨｮｨｰ 09ｨｰ 09ｨｨ02 ｨ 05 0502 0507 CYP2D6*2 ｨｮ09ｨｨ 05ｨｨ 09ｨ 02ｨｰ 000208 ｨｬ02ｨｪ ｨｰｨ ｨｰｨｨ09 ｨｪｨｮ06 ｨ ｨｺ ｨｰｨｨ09 ｨｪ0609ｨｰｨｹ. 0805-0502 05ｨｹ ｨｪ0402 09ｨ 08ｨｨ ｨ ｨｪ ｨｰ04 ｨｨ0406 000208 ｨｬ02ｨｪ ｨｰ0609 CYP2C9 ｨｨ CYP2C19 ｨｰｨ ｨｺ 0302 090907 0404 09ｨ 06ｨｰ 09 ｨｨｨｪｨ ｨｺ ｨｰｨｨ 09ｨ 02ｨｨ02ｨｦ 01ｨ ｨｪ ｨｪ0401 ｨｨ0406 000208 ｨｬ02ｨｪ ｨｰ0609 ｨｨ05ｨｨ 09ｨｪｨｨ0302ｨｪｨｨ02ｨｬ ｨｨ01 ｨ 0000ｨｨｨｪｨｪ0609ｨｰｨｨ ｨｺ 09ｨｮｨ 09ｨｰ08ｨ ｨｰｨｮ [9, 13, 17]. * 04ｨ ｨ 06 ｨｰｨ 0904 070605 ｨｪ02 ｨｪｨ 0708ｨｨ 00ｨｨ ｨｪｨ ｨｪ 0906 0906ｨｦ 070601 010208 03 ｨｺ02 0502 01ｨｹ ｨｬ06ｨｦ 08ｨ ｨｬ06 ﾂ ｨｪ06ｨｦ 070806 0008ｨ ｨｬ ｨｬ04 0309 0806 0702ｨｦ 09ｨｺ06 0006 0906 06 04ｨ 0706 070806 02ｨｺ ｨｰｨｮ Col la bo ra ti ve HIV and Anti-HIV Drug Resistance Network (CHAIN) 01223131, ｨ ｨｰｨ ｨｺ0302 00ｨｨｨｪｨｨ09ｨｰ020809ｨｰ09ｨ 06ｨ 08ｨ 040609ｨ ｨｪｨｨ07 ｨｨ ｨｪｨ ｨｮｨｺｨｨ 04060909ｨｨｨｦ09ｨｺ06ｨｦ 0802010208ｨ 02ｨｨｨｨ, 0906-0005ｨ 0302 ｨｪｨｨ07 8148, 8154 ｨｨ 8479. ISSN 2073-7998 13
13010807 ﾁ010403 020905020404 05ｨｨ05ｨｹｨｪ0602 0905ｨｨ07ｨｪｨｨ02 ｨｪｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨ 05ｨｺ090708020909ｨｨ06 0902 - ｨｬ02ｨｦ 09ｨｰ 09ｨ 000208 ｨｬ02ｨｪ ｨｰ0609 06ｨｺｨ 0404 09ｨ 02ｨｰ ｨｪｨ 05ｨｨ ﾂｨｨ02 0601 ｨｪ06 ｨｪｨｮｨｺ 0502 06 ｨｰｨｨ01 - ｨｪ0401 0706 05ｨｨ ｨｬ0608 00ｨｨ04 ｨｬ0609 (SNP) 09 0002 ｨｪｨ 01, 06ｨｰ 0902ｨｰ 09ｨｰ 0902ｨｪ ｨｪ0401 04ｨ ｨｺ06 01ｨｨ 0806 09ｨ ｨｪｨｨ02 01ｨ ｨｪ ｨｪ0401 000208 ｨｬ02ｨｪ ｨｰ0609. 0306 0709 0502 ｨｪｨｨ02 SNP 09 0002 - ｨｪｨ 01 070806 ｨｨ09 0106 01ｨｨｨｰ 09 0802 04ｨｮ 05ｨｹ ｨｰｨ ｨｰ02 ｨｰ06 ﾂｨｺ06090401 ｨｬｨｮ ｨｰｨ 02ｨｨｨｦ (04ｨ ｨｬ02 ｨｪｨ 0601 ｨｪ06 0006 ｨ 0406 ｨｰｨｨ 09ｨｰ06 0006 0609ｨｪ06 09ｨ ｨｪｨｨ07 0108ｨｮ 00ｨｨｨｬ), ﾂｨｰ06, ｨｺｨ ｨｺ 0708ｨ 09ｨｨ 0506, 0708ｨｨ090601ｨｨｨｰ ｨｺ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ06 05ｨｺ090708020909ｨｨｨｨ ｨｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06-09ｨｰｨｨ 0906 06ｨｰ 0902ｨｰ 09ｨｰ 09ｨｮ 06 ｨｴｨｨ01 ｨｺ06 01ｨｨ 08ｨｮ 02 ｨｬ0401 ｨ 0205 ｨｺ0609. 00ｨｪ0600ｨｨ02 ｨｨ09090502010609ｨ ｨｰ0205ｨｨ ｨｮ0102050706ｨｰ 09ｨｪｨｨｨｬｨ ｨｪｨｨ02 0706ｨｨ09ｨｺｨｮ 0601ｨｪ06ｨｪｨｮｨｺ050206ｨｰｨｨ01ｨｪ0401 070605ｨｨｨｬ060800ｨｨ04ｨｬ0609 (SNP) 09 0002ｨｪｨ 01 000208ｨｬ02ｨｪｨｰ0609 0902ｨｬ02ｨｦ09ｨｰ09ｨ CYP450, ｨｺ06ｨｰ06080402 06ｨｺｨ 040409ｨ 06ｨｰ 0905ｨｨ07ｨｪｨｨ02 ｨｪｨ 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 080406 07ｨｮｨｰ00ｨｬ ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 05ｨｺ090708020909ｨｨｨｨ ｨｨ ｨ ｨｺ - ｨｰｨｨ09ｨｪ0609ｨｰｨｨ 000208ｨｬ02ｨｪｨｰ0609 01ｨ ｨｪｨｪ060006 0902ｨｬ02ｨｦ09ｨｰ09ｨ. 00 ｨｰｨ ｨ 05ｨｨ0202 0708020109ｨｰｨ 090502ｨｪ04 ｨｪ02ｨｺ06ｨｰ06080402 ｨｨ04090209ｨｰｨｪ0402 SNP 09 0002ｨｪｨ 01 000208ｨｬ02ｨｪｨｰ0609 0902ｨｬ02ｨｦ09ｨｰ09ｨ CYP450, ｨｪｨ 0708ｨｨｨｬ0208 ｨｮ0302 ｨｮ09ｨｰｨ ｨｪ06090502ｨｪ06, ﾂｨｰ06 00ｨ 070506ｨｰｨｨ07 CYP2B6*6 09090704ｨ ｨｪ 09 ｨｪｨｨ04ｨｺ06ｨｦ 05ｨｺ090708020909ｨｨ02ｨｦ CYP2B6 ｨ 0205ｨｺｨ, ｨｺ06ｨｰ0608ｨ 07 0708ｨｨ090601ｨｨｨｰ ｨｺ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ06 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ 0500ｨ 09ｨｨ 0802ｨｪ 02ｨ 09 02ｨｨ ｨｰ06 0705ｨ 04 ｨｬ02 ｨｺ0502ｨｰ ｨｺｨｨ [1, 9, 13, 23, 26]. 00ｨ 03ｨｪ04ｨｬ 00ｨ ｨｺｨｰ060806ｨｬ ｨｮ09070203ｨｪ0609ｨｰｨｨ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 080406 0709-0507 02ｨｰ 0907 070802 06 0106 0502 ｨｪｨｨ02 ｨｰｨ ｨｺ ｨｪｨ 0404 09ｨ 02 ｨｬ06ｨｦ ｨｬｨｪ06 0302 09ｨｰ 0902ｨｪ ｨｪ06ｨｦ 0502 - ｨｺｨ 0809ｨｰ0902ｨｪｨｪ06ｨｦ ｨｮ09ｨｰ06ｨｦ ﾂｨｨ090609ｨｰｨｨ 060800ｨ ｨｪｨｨ04ｨｬｨ, 0708020109ｨｰｨ 09050706ｨｴ02ｨｦ 0906ｨ 06ｨｦ 04ｨ ｨｴｨｨｨｰｨｪ04ｨｦ ｨｬ0201ｨ ｨｪｨｨ04ｨｬ, 09ｨｪｨｨ03ｨ 06ｨｴｨｨｨｦ 09ｨｪｨｮｨｰ08ｨｨｨｺ0502ｨｰ06 ﾂ - ｨｪｨｮ06 ｨｺ06ｨｪ 0202ｨｪ ｨｰ 08ｨ 02ｨｨ06 0706 ｨｰ02ｨｪ 02ｨｨ ｨ 05ｨｹ ｨｪ06 ｨｰ06ｨｺ09ｨｨ ﾂ ｨｪ0401 ｨ 0002ｨｪ ｨｰ0609 03ｨｨ0806ｨｺ060006 090702ｨｺｨｰ08ｨ 01ｨｨｨｬｨｨ ﾂ0209ｨｺｨｨ01 0902ｨｴ0209ｨｰ09 (ｨｺ0902ｨｪ06ｨ ｨｨ06ｨｰｨｨ - ｨｺ0609), 09ｨｺ0506 ﾂｨ 07 0502 ｨｺｨ 08 09ｨｰ 0902ｨｪ ｨｪ0402 070802 07ｨ 08ｨ ｨｰ04. 08 09ｨｪｨｮｨｰ 08ｨｨ ｨｺ0502 ｨｰ06 ﾂ ｨｪ04ｨｬ 00ｨ ｨｺ ｨｰ0608ｨ ｨｬ, 0802 ｨ 05ｨｨ 04ｨｮ 06 ｨｴｨｨｨｬ 01ｨ ｨｪ - ｨｪ04ｨｦ ｨｬ0201ｨ ｨｪｨｨ04ｨｬ, 06ｨｰｨｪ060907ｨｰ0907 ｨｰ08ｨ ｨｪ09070608ｨｰｨｪ04ｨｦ ｨ 020506ｨｺ ｨｬｨｪ060302-09ｨｰ 0902ｨｪ ｨｪ06ｨｦ 0502 ｨｺｨ 08 09ｨｰ 0902ｨｪ ｨｪ06ｨｦ ｨｮ09ｨｰ06ｨｦ ﾂｨｨ 0906 09ｨｰｨｨ (MDR) P-0005ｨｨ - ｨｺ0607 0806 ｨｰ02 ｨｨｨｪ (04-gly cop ro te in, P-gp). P-gp 0708ｨｨ ｨｪｨ 01 0502 03ｨｨｨｰ ｨｺ ｨ 06 05ｨｹ 0306 ｨｬｨｮ 0902 ｨｬ02ｨｦ 09ｨｰ 09ｨｮ ABC-ｨｰ08ｨ ｨｪ09 070608 ｨｰ ｨｪ0401 ｨ 0205 ｨｺ0609, 09 0906-09ｨｰｨ 0902 ｨｺ06 ｨｰ06 0806 0006 ｨｨｨｬ02 02ｨｰ 0907 ABCB1. 0806 01ｨｨ 08ｨｮ 02ｨｰ 0907 P-gp ｨｮ ﾂ02 0506-0902 ｨｺｨ 0002 ｨｪ06ｨｬ MDR1, ｨｺ06 ｨｰ06 0804ｨｦ 06ｨｰ 05ｨｨ ﾂｨ 02ｨｰ 0907 04ｨ ｨｬ02ｨｰ ｨｪ04ｨｬ 0706 05ｨｨ - ｨｬ0608 00ｨｨ04 ｨｬ06ｨｬ. 06ｨ ｨｺ, ｨｪｨ 0708ｨｨ ｨｬ0208, 0706 05ｨｨ ｨｬ0608 00ｨｨ04ｨｬ C3435T (04ｨ ｨｬ02 ｨｪｨ 02ｨｨｨｰ0604ｨｨ ｨｪｨ ｨｪｨ ｨｰｨｨ ｨｬｨｨｨｪ) 09 26-ｨｬ 05ｨｺ 0406 ｨｪ02 0002 ｨｪｨ MDR1, 0706 0802 04ｨｮ 05ｨｹ ｨｰｨ - ｨｰｨ ｨｬ ｨｪ02 ｨｺ06 ｨｰ06 080401 08ｨ ｨ 06 ｨｰ, ｨ 09 0906 02ｨｨ ｨｨ 0806 09ｨ ｨｪ 09 00ｨ 08 ｨｬｨ ｨｺ06 ｨｺｨｨ ｨｪ02 ｨｰｨｨ - ｨｺ06ｨｦ ｨｨｨｪ00ｨｨｨ ｨｨｨｰ0608ｨ 070806ｨｰ02ｨ 0404 (0603) 0006 ﾁ-1 ｨｪ020500ｨｨｨｪｨ 09ｨｨ08ｨ. 0308ｨｨ ｨｪｨ 05ｨｨ ﾂｨｨｨｨ 04ｨ ｨｬ02ｨｪ04 05 ｨｪｨ 06 070806ｨｨ09010601ｨｨｨｰ ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 05ｨｺ090708020909ｨｨｨｨ ｨ 0205ｨｺｨ, ﾂｨｰ06 090408ｨ 03ｨ 02ｨｰ0907 09ｨｪｨｨ0302ｨｪｨｨ02ｨｬ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ 07080207ｨ 08ｨ ｨｰｨ 09 02ｨｨｨｰ060705ｨ 04ｨｬ02. 0006 ｨｬｨｪ0600ｨｨ01 08ｨ ｨ 06ｨｰｨ 01 06ｨｰｨｬ02- ﾂｨ 06ｨｰ, ﾂｨｰ06 01ｨ ｨｪ ｨｪ04ｨｦ 09ｨｨ01 0706 05ｨｨ ｨｬ0608 00ｨｨ04 ｨｬｨ ｨｨｨｬ02 02ｨｰ 0905ｨ ｨ 0602 ｨｪ02-08ｨ 09 ｨｪ06 0902 09ｨｪ0602 09020207 0502ｨｪ ｨｨ02 09 0109ｨｮ ｨｬ07 0108ｨｮ 00ｨｨ ｨｬｨｨ SNP ｨ 0205 ｨｺｨ P-gp ｪ G2677T ｨｨ C1236T [7, 20, 23, 25]. 06ｨ ｨｺ 0302 ｨｺｨ ｨｺ ｨｨ P-gp, 0108ｨｮ 00ｨｨ02 ｨｰ08ｨ ｨｪ09 070608 ｨｰ ｨｪ0402 ｨ 0205 ｨｺｨｨ ｨｬｨｪ06-0302 09ｨｰ 0902ｨｪ ｨｪ06ｨｦ 0502 ｨｺｨ 08 09ｨｰ 0902ｨｪ ｨｪ06ｨｦ ｨｮ09ｨｰ06ｨｦ ﾂｨｨ 0906 09ｨｰｨｨ, 09 ﾂｨ 09ｨｰ ｨｪ06 09ｨｰｨｨ MRP, ｨｬ06 00ｨｮｨｰ 06070802 0102 0507ｨｰｨｹ ｨｪｨｨ04 ｨｺｨｮ06 ｨｰ02 08ｨ 070209 ｨｰｨｨ ﾂ02 09ｨｺｨｮ06 ｨｺ06ｨｪ - 0202ｨｪ ｨｰ 08ｨ 02ｨｨ06 0502 ｨｺｨ 08 09ｨｰ 0902ｨｪ ｨｪ0401 070802 07ｨ 08ｨ ｨｰ0609. 01ｨ 0708ｨｨ ｨｬ0208, ｨｮ 07ｨ - 02ｨｨ02ｨｪｨｰ0609, 070605ｨｮ ﾂｨ 06ｨｴｨｨ01 0008080406 ｨｨ ｨｨｨｬ0206ｨｴｨｨ01 ｨｪｨｨ04ｨｺｨｮ06 05ｨｺ0907-080209 09ｨｨ06 MRP1, 06ｨ ｨｪｨ 08ｨｮ 03ｨｨ 05ｨｨ ｨ 06 050202 0904 0906 ｨｺｨｮ06 09ｨｪｨｮｨｰ 08ｨｨ ｨｺ0502 - ｨｰ06 ﾂ ｨｪｨｮ06 ｨｺ06ｨｪ 0202ｨｪ ｨｰ 08ｨ 02ｨｨ06 08ｨｨ ｨｰ06 ｨｪｨ 09ｨｨ 08ｨ ｨｨ 09ｨ ｨｺ 09ｨｨ ｨｪｨ 09ｨｨ 08ｨ, ﾂ02ｨｬ ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 09040906ｨｺ06ｨｦ 05ｨｺ090708020909ｨｨ02ｨｦ MRP1 [7, 25]. 06ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 0002 ｨｪ02 ｨｰｨｨ ﾂ02 09ｨｺｨ 07 09ｨ 08ｨｨ ｨ ｨ 02 05ｨｹ ｨｪ0609ｨｰｨｹ ｨｨ 00ｨｮｨｪ - ｨｺ 02ｨｨ 06 ｨｪｨ 05ｨｹ ｨｪ0609ｨｰｨｹ 0706 05ｨｨ ｨｬ0608 00ｨｨ04 ｨｬ0609 ｨｮ ABC- ｨｨ MRP-ｨ 0205 ｨｺ0609, ｨ ｨｰｨ ｨｺ 0302 ｨｬ02 ｨｰｨ ｨ 06 05ｨｨ 04ｨｨ 08ｨｮ 06 ｨｴｨｨ01 000208 ｨｬ02ｨｪ ｨｰ0609, 09 0906 0906 ｨｺｨｮ07 ｨｪ06 09ｨｰｨｨ 06ｨｰ 08ｨ 03ｨ 0709ｨｹ ｨｪｨ 09ｨ 08ｨｨ ｨ ｨｰｨｨ09 ｨｪ06 09ｨｰｨｨ 0502 ｨｺｨ 08 09ｨｰ 0902ｨｪ ｨｪ06 0006 06ｨｰ 0902 ｨｰｨ, 06ｨｺｨ 0404 09ｨ 02ｨｰ 09ｨｨ 05ｨｹ ｨｪ0602 0905ｨｨ 07 ｨｪｨｨ02 ｨｪｨ 0500 0002ｨｺｨｰ 0708ｨｨ ｨｬ02 ｨｪ02 ｨｪｨｨ07 ｨ ｨｪ - ｨｰｨｨ 0802ｨｰ 0806 09ｨｨ 08ｨｮ09 ｨｪ0401 070802 07ｨ 08ｨ ｨｰ0609. 0402ｨ ｨｺ02ｨｨ07 00ｨｨ070208 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ 0201ｨｪ06 ｨｨ04 ｨｰ070300050401 0609050603ｨｪ02ｨｪｨｨｨｦ, 09 ｨｺ06ｨｰ060804ｨｬ 0708ｨｨ010601ｨｨｨｰ - 0907 09ｨｰｨ 05ｨｺｨｨ09ｨ ｨｰｨｹ0907 0708ｨｨ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨｨｨ ｨ ｨｪｨｰｨｨ0802ｨｰ080609ｨｨ08ｨｮ09ｨｪ0401 070802 07ｨ 08ｨ ｨｰ0609, ｪ 0802 ｨ ｨｺ 02ｨｨ07 00ｨｨ 070208 ﾂｨｮ09 09ｨｰ 09ｨｨ ｨｰ02 05ｨｹ ｨｪ06 09ｨｰｨｨ (0401 ﾁ), ｨｺ06 ｨｰ06 08ｨ 07 0708ｨｨ 06070802 01020500ｨｪｨｪ0401 ｨｮ090506 09ｨｨ 0701 ｨｬ06 0302ｨｰ 0708ｨｨ 0902 09 ｨｰｨｨ ｨｺ 09ｨｬ0208ｨｰｨｨ 07ｨ 02ｨｨ02ｨｪｨｰｨ. 00 ｨｰ0208ｨ 070209ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ 0708ｨ ｨｺｨｰｨｨｨｺ02 0607ｨｨ09ｨ ｨｪ06, 0706 ｨｺ08ｨ ｨｦ ｨｪ02ｨｦ ｨｬ02 0802, 0109ｨ 09ｨｨ 01ｨ 0401 ﾁ ｪ ｨｺ 070802 07ｨ 08ｨ ｨｰｨ ｨｬ 00ｨ ｨ ｨ ｨｺｨ - 09ｨｨ0803 ｨｨ04 0008ｨｮ070704 ｨｪｨｮｨｺ05020604ｨｨ01ｨｪ0401 ｨｨｨｪ00ｨｨｨ ｨｨｨｰ06080609 06ｨ 08ｨ ｨｰｨｪ06ｨｦ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ07ｨｰｨ 0404 (0206) (01060206) ｨｨ 00ｨｪ0209ｨｨ08ｨ 07ｨｨｨｪ03 ｨｨ04 0008ｨｮ070704 ｨｪ02 ｨｪｨｮｨｺ 0502 06 04ｨｨ01 ｨｪ0401 ｨｨｨｪ 00ｨｨ ｨ ｨｨ ｨｰ06 080609 0206 (0101060206). 00 08ｨ ｨ 06 ｨｰｨ 01 ｨｬｨｪ06 00ｨｨ01 ｨｨ09 090502 0106 09ｨ ｨｰ02 0502ｨｦ ｨ 04 0506 0706 ｨｺｨ 04ｨ ｨｪ06, ﾂｨｰ06 0401 ﾁ ｨｺ 05ｨｰｨｨｨｬ 07080207ｨ 08ｨ ｨｰｨ ｨｬ ｨｨｨｬ0202ｨｰ 09090704ｨｹ 09 060906ｨ 02ｨｪｨｪ0609ｨｰ07ｨｬｨｨ 0002 - ｨｪ06ｨｬｨ 01060407ｨｨｨｪｨ. 0308ｨｨｨｬ020806ｨｬ ｨｬ060302ｨｰ 0905ｨｮ03ｨｨｨｰｨｹ 07080609060907ｨ 05ｨｨ - ｨｰ0205ｨｹ ｨｪ04ｨｦ 02ｨｨ ｨｰ06 ｨｺｨｨｨｪ ｪ 00ｨ ｨｺ ｨｰ0608 ｨｪ02 ｨｺ0806 04ｨ 0607ｨｮ 0106 05ｨｨ (TNF-1 7), 06ｨｺｨ 040409ｨ 06ｨｴｨｨｨｦ 0905ｨｨ07ｨｪｨｨ02 ｨｪｨ 05ｨｨ07ｨｨ01ｨｪ04ｨｦ ｨｬ02ｨｰｨ ｨ 0605ｨｨ04ｨｬ, ｨｺ06ｨ 00ｨｮ - 050702ｨｨ06, ｨｮ09ｨｰ06ｨｦ ﾂｨｨ090609ｨｰｨｹ ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ, 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨｨ080609ｨ ｨｪｨｨ02 05ｨｪ0106ｨｰ0205ｨｨ07 ｨｨ ｨ ｨｺｨｰｨｨ09ｨｨ08ｨｮ06ｨｴｨｨｨｦ 07010208ｨｪ04ｨｦ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨ06ｨｪ - ｨｪ04ｨｦ 00ｨ ｨｺ ｨｰ0608 NF-kB. 02ｨｺｨ 04ｨ 050609ｨｹ, ﾂｨｰ06 0706 05ｨｨ ｨｬ0608 00ｨｨ04ｨｬ 30808 09 0002 ｨｪ02 TNF-1 7 ｨ 09090602ｨｨｨｨ080609ｨ ｨｪ 09 00ｨｨ070208 ﾂｨｮ0909ｨｰ09ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ06 ｨｺ ｨ ｨ ｨ ｨｺｨ 09ｨｨ 08ｨｮ ｨｮ 07080201 09ｨｰｨ 09ｨｨ ｨｰ02 0502ｨｦ ｨｪ02 000806 ｨｨ01 ｨｪ06ｨｦ 08ｨ 0904 [21]. 00ｨｪ06 00ｨｨ02 ｨｨ09 090502 0106 09ｨ ｨｰ02 05ｨｨ ｨｪｨ 0106 0107ｨｰ 09090704ｨｹ 0401 ﾁ 09 ﾂ02 0506 0902 - ﾂ02 09ｨｺｨｨ ｨｬｨｨ 0502ｨｦ ｨｺ06 02ｨｨ ｨｰｨ 08 ｨｪ04 ｨｬｨｨ ｨ ｨｪ ｨｰｨｨ 0002 ｨｪｨ ｨｬｨｨ (HLA), ｨｺ06 ｨｰ06 080402 ｨｺ06 01ｨｨ 08ｨｮ 06ｨｰ 0907 0008ｨｮ07 0706ｨｦ 0002 ｨｪ0609 ﾂ02 0506 0902 ﾂ02 09ｨｺ06 0006 ｨｺ06ｨｬ 07 0502ｨｺ 09ｨ 00ｨｨ - 09ｨｰ06090609ｨｬ0209ｨｰｨｨｨｬ0609ｨｰｨｨ (MHC) ｨｨ 0904070605ｨｪ0706ｨｰ 00ｨｮｨｪｨｺ02ｨｨ06 08ｨ 09-0706 04ｨｪｨ 09ｨ ｨｪｨｨ07 ﾂｨｮ 0302 080601 ｨｪ0401 05ｨｨ ｨ 06 0906ｨ 09ｨｰ 0902ｨｪ ｨｪ0401 ｨ ｨｪ ｨｰｨｨ 0002 ｨｪ0609, ｨｨ00 08ｨ 06 ｨｴｨｮ06 09ｨ 03 ｨｪｨｮ06 080605ｨｹ 09 ｨ ｨｺ ｨｰｨｨ 09ｨ 02ｨｨｨｨ ｨｨｨｬ ｨｬｨｮｨｪ ｨｪ06 0006 06ｨｰ 0902 ｨｰｨ. 0102 ｨｪ02 ｨｰｨｨ ﾂ02 09ｨｺｨｨ02 09ｨ 08ｨｨ ｨ ｨｪ ｨｰ04 ｨｨ0406 000208 ｨｬ02ｨｪ ｨｰ0609 0902 ｨｬ02ｨｦ 09ｨｰ 09ｨ CYP450, ｨ 09 0906 02ｨｨ ｨｨ 0806 09ｨ ｨｪ ｨｪ0401 09 0609050603 ｨｪ02 ｨｪｨｨ 07 ｨｬｨｨ, 090604 ｨｪｨｨ ｨｺｨ 06 ｨｴｨｨ ｨｬｨｨ 0708ｨｨ 0008080406 06ｨ ｨ 05ｨｨ 02ｨ 0102ｨｪ SNP 06ｨｪ 0102ｨｪ ｨｰｨｨ 00ｨｨ ｨｺｨ 02ｨｨ 06ｨｪ ｨｪ04ｨｦ ｨｪ06 ｨｬ0208 SNP 0902 ｨｺｨ 08 09ｨｰ 0902ｨｪ ｨｪ04ｨｦ 070802 07ｨ 08ｨ ｨｰ 08ｨ 08ｨｬ0601ｨｨｨｪｨ ｨｬｨｨｨｺｨ CYP2B6 G516T rs3745274 0102 09ｨｨ 08ｨ 07ｨｨｨｪ 0402 ｨ ｨｺ 02ｨｨ07 00ｨｨ 070208 ﾂｨｮ09 09ｨｰ 09ｨｨ ｨｰ02 05ｨｹ ｨｪ06 09ｨｰｨｨ CYP3A4*1B / CYP3A5*1 0600ｨ 09ｨｨ 0802ｨｪ02 0302 08ｨｨ 0002 08ｨｨ ﾂ02 09ｨｺｨ 07 ｨｪ02ｨｦ 0806 07ｨ ｨｰｨｨ07 T983C rs28399499 0102 09ｨｨ 08ｨ 07ｨｨｨｪ 0402 ｨ ｨｺ 02ｨｨ07 00ｨｨ 070208 ﾂｨｮ09 09ｨｰ 09ｨｨ ｨｰ02 05ｨｹ ｨｪ06 09ｨｰｨｨ 0600ｨ 09ｨｨ 0802ｨｪ02 06ｨｪ 01ｨｨ ｨｪｨ 09ｨｨ08 0302 08ｨｨ 0002 08ｨｨ ﾂ0209ｨｺｨ 07 ｨｪ02ｨｦ 0806 07ｨ ｨｰｨｨ07 01ｨｨ07 070208 ｨ ｨｨ 05ｨｨ 08ｨｮ ｨ ｨｨ ｨｪ02 ｨｬｨｨ07 010200 0806 05ｨｨ ｨｰｨｨ ｨ 04 14
130003020600060105080808 0103010306060808. ｪ 2013. ｪ 012 01ｨ 05ｨｨ ﾂｨｨ02 ｨ 05 0502 0507 HLA-B*5701 ｨｰ0209ｨｪ06 ｨ 09090602ｨｨｨｨ080609ｨ ｨｪ06 09 0802 ｨ ｨｺ 02ｨｨ02ｨｦ 00ｨｨ 070208 ﾂｨｮ09 09ｨｰ 09ｨｨ ｨｰ02 05ｨｹ ｨｪ06 09ｨｰｨｨ ｨｺ ｨ ｨ ｨ ｨｺｨ 09ｨｨ 08ｨｮ ｨｨ 020006 070806 - ｨｨ04 090601 ｨｪ04ｨｬ 090802 01ｨｨ 05ｨｨ02 0209 0806 070206 ｨｨ01 ｨｪ06ｨｦ 08ｨ 0904; 020006 0909ｨｰ0802 ﾂｨ 02 - ｨｬ0609ｨｰｨｹ 09 020908060702ｨｦ09ｨｺ06ｨｦ 070607ｨｮ050702ｨｨｨｨ 09 09080201ｨｪ02ｨｬ 090609ｨｰｨ 09050702ｨｰ 3 ｪ8% [26]. 06ｨｰ06ｨｰ 0708ｨｨ ｨｬ0208 ｨ ｨｺ ｨｰｨｨ09 ｨｪ06 06ｨ 09ｨｮ03 01ｨ 05 0907 09 05ｨｨ ｨｰ02 08ｨ ｨｰｨｮ - 0802 [18, 22] ｨｨ 0106 09ｨｨ01 070608 09 ﾂｨｨｨｰｨ 02ｨｰ 0907 ｨｪｨ ｨｨ ｨ 06 050202 ｨｮ01ｨ ﾂ ｨｪ04ｨｬ, ｨｰ.02. ｨｨｨｬ0206ｨｴｨｨｨｬ ｨｬｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪｨｮ06 07080600ｨｪ0609ｨｰｨｨ ﾂ0209ｨｺｨｮ06 0202ｨｪｨｪ0609ｨｰｨｹ, 09 06ｨｰｨｪ060302ｨｪｨｨｨｨ 0609050603ｨｪ02ｨｪｨｨｨｦ 0502 ﾂ02ｨｪｨｨ07 0006 ﾁ-ｨｨｨｪ0002ｨｺ02ｨｨｨｨ. 01ｨ 0708ｨ ｨｺ ｨｰｨｨ ｨｺ02, ｨｮ0708ｨ 09 0502 ｨｪｨｨ02 0706 ｨｺ06ｨｪ ｨｰ 0806 0506 ｨｺｨ ﾂ02 09ｨｰ 09ｨ 07ｨｨ - ｨｴ02 090401 070806 01ｨｮｨｺ ｨｰ0609 ｨｨ 0502 ｨｺｨ 08 09ｨｰ 0902ｨｪ ｨｪ0401 070802 07ｨ 08ｨ ｨｰ0609 050108 (FDA) 09 2008 00. 0802ｨｺ06ｨｬ02ｨｪ01ｨｮ02ｨｰ 070806090601ｨｨｨｰｨｹ ｨｰ0209ｨｰｨｨ080609ｨ ｨｪｨｨ02 07ｨ - 02ｨｨ 02ｨｪ ｨｰ0609 ｨｪｨ HLA-B*5701 0702 080201 ｨｪｨ 04ｨｪｨ ﾂ02 ｨｪｨｨ 02ｨｬ ｨｰ02 08ｨ 07ｨｨｨｨ ｨ ｨ ｨ ｨｺｨ 09ｨｨ 0806ｨｬ, ﾂｨｰ06 09ｨｪｨｨ 03ｨ 02ｨｰ 08ｨｨ09ｨｺ 08ｨ 04 09ｨｨ ｨｰｨｨ07 0401 ﾁ ｨｺ 070802 07ｨ 08ｨ - ｨｰｨｮ. 00 040609 09ｨｨｨｨ 01ｨ ｨｪ ｨｪ0602 ｨｰ02 09 ｨｰｨｨ 0806 09ｨ ｨｪｨｨ02 0802 ｨｺ06 ｨｬ02ｨｪ 0106 09ｨ ｨｪ06 09 2009 00. (0308ｨｨ ｨｺｨ 04 040609 04 01 08ｨ 09 ｨｪｨ 01 0406 08ｨ 06ｨｰ 03.12.2009). 03ｨｴ00 0601ｨｪｨｨｨｬ 0708ｨｨｨｬ020806ｨｬ 0905ｨｨ07ｨｪｨｨ07 ｨｪｨ 05000002ｨｺｨｰ 0008080406 ｨｬ06 0302ｨｰ 0905ｨｮ 03ｨｨｨｰｨｹ ｨ 05 0502 05ｨｹ ｨｪ04ｨｦ 09ｨ 08ｨｨ ｨ ｨｪｨｰ HLA-DRB1*0101, ｨｺ06 - ｨｰ06 0804ｨｦ, 090604 ｨｬ0603 ｨｪ06, 0709 0507 02ｨｰ 0907 ｨｨｨｬ ｨｬｨｮ ｨｪ06 0002 ｨｪ02 ｨｰｨｨ ﾂ02 09ｨｺｨｨｨｬ ｨｬｨ 08ｨｺ000806ｨｬ 00ｨｨ 070208 ﾂｨｮ09 09ｨｰ 09ｨｨ ｨｰ02 05ｨｹ ｨｪ06 09ｨｰｨｨ ｨｺ ｨｪ02 09ｨｨ 08ｨ 07ｨｨ ｨｪｨｮ, 0708060709050706ｨｴ02ｨｦ0907 ｨｪ0209ｨｨ08ｨ 07ｨｨｨｪ09090704ｨ ｨｪｨｪ04ｨｬｨｨ 000207ｨ ｨｰｨｨｨｰｨ ｨｬｨｨ ｨｨ 0904 07ｨｹ06 ｨｮ 02090806070206ｨｨ010609. 080806 ｨｬ02 ｨ 05 0502 0507 HLA-DRB1*0101 09 00ｨｨ 070208 ﾂｨｮ09 09ｨｰ 09ｨｨ ｨｰ02 05ｨｹ ｨｪ06 09ｨｰｨｹ06 ｨｺ ｨｪ02 09ｨｨ 08ｨ 07ｨｨ ｨｪｨｮ 090907 0404 09ｨ 06ｨｰ 02ｨｴ00 ｨｪ02 09ｨｺ06 05ｨｹ ｨｺ06 ｨ 05 0502 0502ｨｦ: HLA-Cw*8, HLA-B*14, HLA-Cw*4, HLA-B*3505 [2, 14, 23, 26, 27]. 08ｨ ｨｺ 09ｨｨ01 ｨｪ06 ｨｨ04 0708ｨｨ 09020100ｨｪｨｪ0401 01ｨ ｨｪ ｨｪ0401, 0802 ｨ ｨｺ 02ｨｨ07 00ｨｨ 070208 - ﾂｨｮ09 09ｨｰ 09ｨｨ ｨｰ02 05ｨｹ ｨｪ06 09ｨｰｨｨ ｨｨｨｬ02 02ｨｰ ｨ 06 050202 09ｨｨ 05ｨｹ ｨｪｨｮ06 09090704ｨｹ 09 060906 ｨ 02ｨｪ - ｨｪ06 09ｨｰ07 ｨｬｨｨ 0002 ｨｪ06 ｨｬｨ 0106 0407 ｨｨ ｨｪｨ, ﾂ02ｨｬ 05ｨｰ06 07080201 09ｨｰｨ 09 0507 050609ｨｹ 08ｨ ｨｪ0202. 06ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 04ｨｪｨ ｨｪｨｨ02 06 01ｨ ｨｪｨｪ06ｨｦ 060906ｨ 02ｨｪｨｪ0609ｨｰｨｨ 09090704ｨｨ 0401 ﾁ 09 0002ｨｪ ｨｪ04 ｨｬｨｨ 00ｨ ｨｺ ｨｰ06 08ｨ ｨｬｨｨ ﾂ02 0506 0902 ｨｺｨ 01ｨ 00ｨｰ 090604 ｨｬ0603 ｨｪ0609ｨｰｨｹ ｨｪｨ 0708ｨ ｨｺｨｰｨｨｨｺ02 09ｨｪｨｨ04ｨｨｨｰｨｹ ﾂｨｨ090506 0905ｨｮ ﾂｨ 0209 0401 ﾁ, 090604ｨｪｨｨｨｺｨ 06ｨｴｨｨ01 ｨｮ 0006 ﾁ-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 ｨｨｨｪ01ｨｨ09ｨｨ01ｨｮｨｮｨｬ0609, ｨｪｨ 01060107ｨｴｨｨ010907 ｨｪｨ 080406. 09ｨｨ 0706 01ｨｨ 09ｨｰ 0806 00ｨｨ07 09ｨｨ 0706 01ｨｨ 09ｨｰ 0806 00ｨｨ07 07080201 09ｨｰｨ 09 0507 02ｨｰ 0906 ｨ 06ｨｦ 0601 ｨｪ06 ｨｨ04 ｨｰ070300050401 0609050603ｨｪ02ｨｪｨｨｨｦ, 090604ｨｪｨｨｨｺｨ 06ｨｴｨｨ01 ｨｮ 0006 ﾁ-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 07ｨ 02ｨｨ02ｨｪｨｰ0609 0708ｨｨ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨｨｨ ｨ ｨｪｨｰｨｨ0802ｨｰ080609ｨｨ08ｨｮ09ｨｪ0401 07080207ｨ 08ｨ ｨｰ0609, 09ｨｺ0506 ﾂｨ 07 ｨｨｨｪ 00ｨｨ ｨ ｨｨ ｨｰ06 0804 070806 ｨｰ02 ｨ 0404, ｨｨ 01ｨ 08ｨ ｨｺ ｨｰ02 08ｨｨ 04ｨｮ 02ｨｰ - 0907, 09 070208 09ｨｮ06 06 ﾂ02 080201ｨｹ, 0706 ｨｰ02 0802ｨｦ 070601 ｨｺ0603 ｨｪ06ｨｦ 03ｨｨ 0806 0906ｨｦ ｨｺ0502ｨｰ ﾂｨ ｨｰ ｨｺｨｨ 09 06ｨ 05ｨ 09 ｨｰｨｨ 05ｨｨ 02ｨ, 08ｨｮｨｺ ｨｨ ｨｪ0600. 07 ｨｪ02 ｨｺ06 ｨｰ06 080401 0006 ﾁ-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 05ｨｨ02 05ｨｨ070601ｨｨ09ｨｰ080600ｨｨ07 ｨｬ060302ｨｰ 070806 - ｨｰ02ｨｺｨ ｨｰｨｹ 09 090607ｨｮｨｰ09ｨｰ09ｨｮ06ｨｴｨｨｨｬ 06ｨｰ05060302ｨｪｨｨ02ｨｬ 05ｨｨ03ｨｪ020006 03ｨｨ08ｨ 09 06ｨ 05ｨ 09ｨｰｨｨ 0302ｨｨ ｨｨ 09020801ｨｪ02ｨｦ ﾂｨ 09ｨｰｨｨ 0907ｨｨｨｪ04, ﾂｨｰ06 0708ｨｨ090601ｨｨｨｰ ｨｺ 06ｨ - 08ｨ 040609ｨ ｨｪｨｨ06 010906ｨｦｨｪ060006 070601ｨ 06080601ｨｺｨ ｨｨ 000608ｨ ｨｮ ｨｪｨ 0907ｨｨｨｪ02 (00000608ｨ ｨ ｨｮｨｦ 0906 05ｨ 03). 09ｨｨ070601ｨｨ09ｨｰ080600ｨｨ07 08ｨ 0409ｨｨ09ｨ 02ｨｰ0907 0708ｨｨｨｬ0208ｨｪ06 ｨｮ 40% 07ｨ 02ｨｨ - 02ｨｪ ｨｰ0609 09 ｨｰ02 ﾂ02 ｨｪｨｨ02 0006 01ｨ 0706 090502 ｨｪｨ ﾂｨ 05ｨ 0502 ﾂ02 ｨｪｨｨ07, 0209 05ｨｨ 09 090102 ｨｬ04 ｨ ｨｪ ｨｰｨｨ 0802ｨｰ 0806 09ｨｨ 08ｨｮ09 ｨｪ06 0006 0502 ﾂ02 ｨｪｨｨ07 09ｨｺ0506 ﾂ02 ｨｪ04 ｨｨｨｪ 00ｨｨ ｨ ｨｨ ｨｰ06 0804 070806ｨｰ02ｨ 0404. 06ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 0708ｨｨ06ｨ 0802ｨｰ00ｨｪｨｪｨ 07 05ｨｨ070601ｨｨ09ｨｰ0806-00ｨｨ07 ｨｮ 0006 ﾁ-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 05ｨｨ02, 070605ｨｮ ﾂｨ 06ｨｴｨｨ01 080406, ｪ 03ｨｨ0806ｨｺ06 08ｨ 0907080609ｨｰ08ｨ ｨｪ00ｨｪｨｪ0602 0609050603ｨｪ02ｨｪｨｨ02. 090605ｨｹ03ｨｨｨｪ09ｨｰ0906 0006 ﾁ-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 ｨｨｨｪ01ｨｨ09ｨｨ01ｨｮｨｮｨｬ0609 09 05ｨｨ070601ｨｨ09ｨｰ080600ｨｨ02ｨｦ ｨｬ0600ｨｮｨｰ 09 ﾂｨｨｨｰｨ ｨｰｨｹ0907 06ｨｰｨｪ0609ｨｨｨｰ0205ｨｹｨｪ06 0401060806-0904ｨｬｨｨ, 0601ｨｪｨ ｨｺ06 ｨｪ02080201ｨｺ06 06ｨｪｨ 090607080609060301ｨ 02ｨｰ0907 080204ｨｨ09ｨｰ02ｨｪｨｰｨｪ06-09ｨｰｨｹ06 ｨｺ ｨｨｨｪ09ｨｮ05ｨｨｨｪｨｮ, 00ｨｨ070208ｨｰ08ｨｨ0005ｨｨ020208ｨｨ0102ｨｬｨｨ02ｨｦ ｨｨ 09ｨｪｨｨ0302ｨｪｨｨ02ｨｬ ｨｮ080609ｨｪ07 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨｨｨ 05ｨｨ0706070806ｨｰ02ｨｨｨｪ0609 09040906ｨｺ06ｨｦ 070506ｨｰｨｪ06-09ｨｰｨｨ 09 0705ｨ 04 ｨｬ02 ｨｺ0806 09ｨｨ. 08ｨ ｨｺ ｨｨ 0607ｨｨ 09ｨ ｨｪ ｨｪ0402 0106 05ｨｰ06 0006 08ｨ ｨｪ0202 0609050603 ｨｪ02 ｨｪｨｨ07, 05ｨｨ 0706-01ｨｨ 09ｨｰ 0806 00ｨｨ07, ｨｺｨ ｨｺ 06ｨｺｨ 04ｨ 050609ｨｹ, ｨｰ06 0302 ｨｨｨｬ02 02ｨｰ 09090704ｨｹ 09 0002 ｨｪ06 ｨｬ06ｨｬ ﾂ0205060902ｨｺｨ. 06ｨ ｨｺ, ｨ 040506 04ｨ ｨｬ02 ﾂ02ｨｪ06, ﾂｨｰ06 070605ｨｨｨｬ060800ｨｨ04ｨｬ 053954T 0002 ｨｪｨ IL-11 7, ｨｺ0601ｨｨ08ｨｮ06ｨｴ020006 07080609060907ｨ 05ｨｨｨｰ0205ｨｹｨｪ04ｨｦ 02ｨｨｨｰ06ｨｺｨｨｨｪ ｪ ﾂ0502ｨｪ 0902 ｨｬ02ｨｦ 09ｨｰ 09ｨ ｨｨｨｪ ｨｰ0208 0502ｨｦ ｨｺｨｨ ｨｪｨ 1, 09ｨｪｨｨ 03ｨ 02ｨｰ 08ｨｨ09ｨｺ 08ｨ 04 09ｨｨ - ｨｰｨｨ07 05ｨｨ070601ｨｨ09ｨｰ080600ｨｨｨｨ ｨｮ 0006 ﾁ-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 07ｨ 02ｨｨ02ｨｪ - ｨｰ0609, ｨｪｨ 01060107ｨｴｨｨ010907 ｨｪｨ 0008080406 ｨｨ 0708ｨｨｨｪｨｨｨｬｨ 06ｨｴｨｨ01, 09 ﾂｨ 09ｨｰｨｪ06-09ｨｰｨｨ, 09ｨｰｨ 09ｨｮ 01ｨｨｨｪ ｨｨ04 0008ｨｮ07 0704 01060206 [6]. 0306 05ｨｨ ｨｬ0608 00ｨｨ04ｨｬ 23808 0002 ｨｪｨ TNF-1 7 090907040409ｨ 06ｨｰ 09 05ｨｨ070601ｨｨ09ｨｰ080600ｨｨ02ｨｦ, ｨｪ02080201ｨｺ06 ｨｪｨ - ｨ 0506 01ｨ 02 ｨｬ06ｨｦ ｨｮ 07ｨ 02ｨｨ 02ｨｪ ｨｰ0609 0209 0806 070206 ｨｨ01 ｨｪ06ｨｦ 08ｨ 0904, 0706 05ｨｮ ﾂｨ 06 - ｨｴｨｨ01 09 ｨｺｨ ﾂ02 09ｨｰ 0902 0502 ﾂ02 ｨｪｨｨ07 070802 07ｨ 08ｨ ｨｰ04 0008ｨｮ07 0704 01060206 [21, 24]. 03ｨｴ00 0601ｨｨｨｪ 0002ｨｪ IL-18, ｨ 09090602ｨｨｨｨ080609ｨ ｨｪｨｪ04ｨｦ, 0706 ｨｬｨｪ02ｨｪｨｨ06 ｨｪ02ｨｺ06ｨｰ06080401 ｨ 09ｨｰ06080609 [10], 09 05ｨｨ070601ｨｨ09ｨｰ080600ｨｨ02ｨｦ, 090601020803ｨｨｨｰ ｨｪ0209ｨｺ0605ｨｹｨｺ06 070605ｨｨｨｬ060800ｨｨ04ｨｬ0609, ｨｺ06ｨｰ06080402 09 ｨｺ06ｨｬｨ ｨｨｨｪｨ 02ｨｨｨｨ ｨ 09-090602ｨｨｨｨ08ｨｮ06ｨｰ0907 09 04ｨ ｨｴｨｨｨｰｨｪ04ｨｬ 05000002ｨｺｨｰ06ｨｬ 070806ｨｰｨｨ09 05ｨｨ070601ｨｨ09ｨｰ - 080600ｨｨｨｨ. 0306 05ｨｨ ｨｬ0608 00ｨｨ04 ｨｬ04 T455C, C482T ｨｨ C3238G 0002 ｨｪｨ APOC3, ｨｺ0601ｨｨ08ｨｮ06ｨｴ020006 ｨ 070605ｨｨ0706070806ｨｰ02ｨｨｨｪ 0705ｨ 04ｨｬ04 ｨｺ080609ｨｨ ｨｨ04 0008ｨｮ070704 05ｨｨ0706070806ｨｰ02ｨｨｨｪ0609 ｨｪｨｨ04ｨｺ06ｨｦ ｨｨ 09040906ｨｺ06ｨｦ 070506ｨｰｨｪ0609ｨｰｨｨ, 0706 0802 04ｨｮ 05ｨｹ ｨｰｨ ｨｰｨ ｨｬ ｨｪ02 ｨｺ06 ｨｰ06 080401 ｨｨ09 090502 0106 09ｨ ｨｪｨｨｨｦ, 0708ｨｨ 0906 0107ｨｰ ｨｺ ｨｮ0902-05ｨｨ ﾂ02ｨｪｨｨ06 090601020803ｨ ｨｪｨｨ07 ｨｰ08ｨｨ0005ｨｨ020208ｨｨ010609 09 ｨｺ080609ｨｨ 0708ｨｨ 0708ｨｨ - ｨｬ02ｨｪ02ｨｪｨｨｨｨ ｨ ｨｪｨｰｨｨ0802ｨｰ080609ｨｨ08ｨｮ09ｨｪ0401 07080207ｨ 08ｨ ｨｰ0609 ｨｨ04 0008ｨｮ070704 0603, 09 ﾂｨ 09ｨｰ ｨｪ06 09ｨｰｨｨ 08ｨｨ ｨｰ06 ｨｪｨ 09ｨｨ 08ｨ ; 05ｨｰ06, 09 09090606 06 ﾂ02 080201ｨｹ, ｨｮ0902 05ｨｨ ﾂｨｨ 09ｨ - 02ｨｰ 08ｨｨ09ｨｺ 05ｨｨ070601ｨｨ09ｨｰ080600ｨｨｨｨ ｨｨ 0902080102 ﾂｨｪ06-090609ｨｮ01ｨｨ09ｨｰ0401 04ｨ ｨ 060502-09ｨ ｨｪｨｨｨｦ [8]. 01ｨ 05ｨｨ ﾂｨｨ02 05ｨｨ070601ｨｨ09ｨｰ080600ｨｨｨｨ ｨｮ 0006 ﾁ-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 ｨｨｨｪ01ｨｨ09ｨｨ01ｨｮｨｮｨｬ0609, ｨｪｨ 01060107ｨｴｨｨ010907 ｨｪｨ 0008080406, 090907040409ｨ 06ｨｰ ｨｰｨ ｨｺ0302 09 070605ｨｨｨｬ060800ｨｨ04ｨｬｨ ｨｬｨｨ 0002ｨｪ0609 Fas, ARb2, ARb3, HFE, LPIN1 ｨｨ05ｨｨ POLG [11, 15, 19, 28]. 0102ｨｦ080607ｨ ｨｰｨｨ07 0102 080201 ｨｺ06 ｨｮ 0006 ﾁ-ｨｨｨｪ 00ｨｨ 02ｨｨ 0806 09ｨ ｨｪ ｨｪ0401 05ｨｨ02, ｨｪｨ 0106 0107 ｨｴｨｨ01 0907 ｨｪｨ 080406, ｨｪｨ ｨ 050601ｨ 06ｨｰ0907 08ｨ 0405ｨｨ ﾂｨｪ0402 0609050603ｨｪ02ｨｪｨｨ07 0906 09ｨｰ060806 - ｨｪ04 ｨｪ020809ｨｪ06ｨｦ 09ｨｨ09ｨｰ02ｨｬ04; 0708ｨｨｨｬ020806ｨｬ ｨｬ060302ｨｰ 0905ｨｮ03ｨｨｨｰｨｹ 070208ｨｨ000208ｨｨ ﾂ0209ｨｺｨ 07 ｨｪ02ｨｦ080607ｨ ｨｰｨｨ07. 030208ｨｨ000208ｨｨ ﾂ0209ｨｺｨ 07 ｨｪ02ｨｦ 0806 07ｨ ｨｰｨｨ07 ｪ 05ｨｰ06 0906 09ｨｰ06 07 ｨｪｨｨ02, 0904 0409ｨ ｨｪ ｨｪ0602 0706 09080203 0102 ｨｪｨｨ 02ｨｬ 0601 ｨｪ06 0006 ｨｨ05ｨｨ ｨｪ02-09ｨｺ0605ｨｹ ｨｺｨｨ01 0702 08ｨｨ 0002 08ｨｨ ﾂ02 09ｨｺｨｨ01 ｨｪ0208 090609, 0708ｨｨ 0906 0107 ｨｴ0202 ｨｺ ｨｪｨ 08ｨｮ - 0302ｨｪｨｨ06 06ｨ ｨｬ02ｨｪｨ 09ｨｨ00ｨｪｨ 05ｨ ｨｬｨｨ ｨｬ020301ｨｮ 0202ｨｪｨｰ08ｨ 05ｨｹｨｪ06ｨｦ ｨｨ 070208ｨｨ - 000208ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｪ020809ｨｪ04ｨｬｨｨ 09ｨｨ09ｨｰ02ｨｬｨ ｨｬｨｨ. 05ｨｨｨｬ07ｨｰ06ｨｬ04 070208ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｪ02ｨｦ080607ｨ ｨｰｨｨｨｨ 08ｨ 0409ｨｨ09ｨ 06ｨｰ0907 070609ｨｰ020702ｨｪｨｪ06 ｨｨ ｨｬ0201-0502ｨｪｨｪ06 0708060008020909ｨｨ08ｨｮ06ｨｰ; ﾂｨ ｨｴ02 0909020006, 07ｨ 02ｨｨ02ｨｪｨｰ04 ｨｨ090704ｨｰ0409ｨ - 06ｨｰ 0706 ｨｺｨ 0504 09ｨ ｨｪｨｨ02 ｨｨ 06ｨｪ02 ｨｬ02 ｨｪｨｨ02, ｨｺ06 ｨｰ06 080402 09ｨｪｨ ﾂｨ 05ｨ ｨｪｨ ﾂｨｨ ｨｪｨ - 06ｨｰ 0907 09 ｨｺｨｨ 09 ｨｰ0701 08ｨｮｨｺ ｨｨ 09ｨｰ06 07ｨ 01, ｨ 04ｨ ｨｰ02ｨｬ 08ｨ 09 070806 09ｨｰ08ｨ ｨｪ07 06ｨｰ 0907 ｨｪｨ 090900 ｨｰ02 0506. 06ｨｰ06ｨｰ 09ｨｨ01 0609050603ｨｪ02ｨｪｨｨｨｦ ﾂｨ ｨｴ02 0909020006 090907040409ｨ 06ｨｰ 09 0706ｨ 06 ﾂ - ｨｪ04ｨｬ 0500 0002ｨｺ ｨｰ06ｨｬ 070802 07ｨ 08ｨ ｨｰ0609 0008ｨｮ07 0704 01060206, 0708ｨｨ 05ｨｰ06ｨｬ ｨｬｨｪ06 00ｨｨ02 ｨｨ09 090502 0106 09ｨ ｨｪｨｨ07 06ｨ ｨｪｨ 08ｨｮ 03ｨｨ 09ｨ 06ｨｰ 09090704ｨｹ ｨｬ0203 01ｨｮ 0702 08ｨｨ - 0002 08ｨｨ ﾂ02 09ｨｺ06ｨｦ ｨｪ02ｨｦ 0806 07ｨ ｨｰｨｨ02ｨｦ ｨｨ 0002 ｨｪ06 ｨｬ06ｨｬ ﾂ02 0506 0902 ｨｺｨ. 06ｨ ｨｺ, 0708ｨｨ 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨｨｨ 09ｨｰｨ 09ｨｮ01ｨｨｨｪｨ ｨｨ 020006 070806ｨｨ04090601ｨｪ0401 ｨｮ 0006 ﾁ-ｨｨｨｪ 00ｨｨ 02ｨｨ 0806 09ｨ ｨｪ ｨｪ0401 07ｨ 02ｨｨ 02ｨｪ ｨｰ0609, 09 0002 ｨｪ06 ｨｬ02 ｨｺ06 ｨｰ06 080401 ｨｨｨｬ0206ｨｰ0907 070605ｨｨｨｬ060800ｨｨ04ｨｬ04 C2890T ｨｨ A3428G 0002ｨｪｨ POLG ｨｬｨｨｨｰ060106ｨｪ0108ｨｨｨ 05ｨｹｨｪ06ｨｦ 020108, ｨｺ0601ｨｨ08ｨｮ06ｨｴ020006 ｨｬｨｨｨｰ060106ｨｪ0108ｨｨｨ 05ｨｹｨｪｨｮ06 1 7-020108-0706 05ｨｨ ｨｬ02 08ｨ 04ｨｮ, ｨｪｨ ｨ 0506 01ｨ 02ｨｰ 0907 08ｨｨ09ｨｺ 08ｨ 04 09ｨｨ ｨｰｨｨ07 0702-08ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｪ02ｨｦ080607ｨ ｨｰｨｨｨｨ [3]. ISSN 2073-7998 15
13010807 ﾁ010403 020905020404 030605ｨｨｨｬ060800ｨｨ04ｨｬ04 G516T ｨｨ C983T 09 0002ｨｪ02, ｨｺ0601ｨｨ08ｨｮ06ｨｴ02ｨｬ ｨｬ02ｨｰｨ ｨ 0605ｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｨ0406000208ｨｬ02ｨｪｨｰ CYP2B6, ｨ 09090602ｨｨｨｨ080609ｨ ｨｪ04 09 09ｨｨ05ｨｹｨｪ04ｨｬ 070609040302ｨｪｨｨ02ｨｬ 08ｨｨ09ｨｺｨ 070607090502ｨｪｨｨ07 070208ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｪ02ｨｦ080607ｨ ｨｰｨｨｨｨ ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ0609, 070605ｨｮ ﾂｨ 06ｨｴｨｨ01 0500ｨ 09ｨｨ0802ｨｪ02. 08ｨｪｨ 050600ｨｨ ﾂｨｪ0402 060905060302ｨｪｨｨ07 0502 ﾂ02ｨｪｨｨ07 0500ｨ 09ｨｨ0802ｨｪ0202ｨｬ 090907040409ｨ 06ｨｰ 09 ｨｪｨ 05ｨｨ ﾂｨｨ02ｨｬ 070605ｨｨｨｬ060800ｨｨ04ｨｬｨ C3435T 0002ｨｪｨ MDR1 [16]. 0208ｨｮ 00ｨｨ02 0609050603 ｨｪ02 ｨｪｨｨ07 0008080406 00 090002 0802 ｨｨｨｪ ｨｰ02 0802 090609 ｨｨ09 090502 0106 09ｨ ｨｰ02 0502ｨｦ 090802 01ｨｨ 0609050603 ｨｪ02 - ｨｪｨｨｨｦ, 0909ｨｰ0802 ﾂｨ 06ｨｴｨｨ010907 ｨｮ 0006 ﾁ-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 07ｨ 02ｨｨ02ｨｪ - ｨｰ0609, 0706 05ｨｮ ﾂｨ 06 ｨｴｨｨ01 090702 02ｨｨ 00ｨｨ ﾂ02 09ｨｺ0602 0502 ﾂ02 ｨｪｨｨ02, ｨｪｨ 0106 01ｨｨｨｰ 0907 ｨｰｨ ｨｺ0302 00ｨｨ070208ｨ ｨｨ05ｨｨ08ｨｮｨ ｨｨｨｪ02ｨｬｨｨ07 ｪ 090609ｨｰ0607ｨｪｨｨ02, 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ04ｨｮ02ｨｬ0602 ｨｮ0902 05ｨｨ ﾂ02ｨｪ ｨｪ04ｨｬ ｨｺ06 05ｨｨ ﾂ02 09ｨｰ 0906ｨｬ 09 0904 0906 0806ｨｰ ｨｺ02 ｨｺ0806 09ｨｨ 030205 - ﾂｨｪ060006 07ｨｨ00ｨｬ02ｨｪｨｰｨ ｨ ｨｨ05ｨｨ08ｨｮｨ ｨｨｨｪｨ. 080208 ｨｬ02ｨｪｨｰ UGT1A1 ｨｰ08ｨ ｨｪ09 000608 ｨｬｨｨ 08ｨｮ 02ｨｰ ｨｪ02 ｨ 06 05ｨｹ 03ｨｨ02 05ｨｨ 0706-00ｨｨ 05ｨｹ ｨｪ0402 ｨｬ06 0502 ｨｺｨｮ 0504, ｨｰｨ ｨｺｨｨ02, ｨｺｨ ｨｺ ｨ ｨｨ 05ｨｨ 08ｨｮ ｨ ｨｨｨｪ, 09ｨｰ02 0806 ｨｨ 0104, 000608 ｨｬ06 ｨｪ04, 0502 ｨｺｨ 08 09ｨｰ 0902ｨｪ ｨｪ0402 0902 ｨｴ02 09ｨｰ 09ｨ, 09 0906 0106 08ｨ 09ｨｰ 0906 08ｨｨ ｨｬｨｮ06 000608ｨｬｨｮ, 0708ｨｨ000601ｨｪｨｮ06 010507 01ｨ 05ｨｹｨｪ02ｨｦ0302ｨｦ 05ｨｺ09ｨｺ080202ｨｨｨｨ. 02ｨｪ 06ｨｺｨ - 0404 09ｨ 02ｨｰ 0905ｨｨ 07 ｨｪｨｨ02 ｨｨ ｨｪｨ ｨｰ06ｨｺ09ｨｨ ﾂ ｨｪ0609ｨｰｨｹ ｨ ｨｪ ｨｰｨｨ 0802ｨｰ 0806 09ｨｨ 08ｨｮ09 ｨｪ0401 070802 07ｨ 08ｨ ｨｰ0609 ｪ ｨ ｨｰｨ 04ｨ ｨｪｨ 09ｨｨ 08ｨ, ｨｨｨｪ 01ｨｨ ｨｪｨ 09ｨｨ 08ｨ ｨｨ04 0008ｨｮ07 0704 ｨｨｨｪ 00ｨｨ - ｨ ｨｨ ｨｰ06 080609 070806 ｨｰ02 ｨ 04, ｨｨ ｨｪｨ ｨｮ0806 0902ｨｪｨｹ ｨ ｨｨ 05ｨｨ 08ｨｮ ｨ ｨｨ ｨｪｨ 09 ｨｺ0806 09ｨｨ ｨｮ 0006 ﾁ-ｨｨｨｪ 00ｨｨ 02ｨｨ 0806 09ｨ ｨｪ ｨｪ0401 07ｨ 02ｨｨ 02ｨｪ ｨｰ0609. 08ｨ ｨｺ ｨ 04 0506 06ｨ ｨｪｨ 08ｨｮ 0302 - ｨｪ06, ｨｪｨ 05ｨｨ ﾂｨｨ02 ｨ 05 0502 0507 UGT1A1*28, 09090704ｨ ｨｪｨｪ060006 0906 09ｨｪｨｨ0302ｨｪｨｨ - 02ｨｬ ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨｨｨ 01ｨ ｨｪｨｪ060006 000208ｨｬ02ｨｪｨｰｨ, 0706090403ｨ 02ｨｰ 08ｨｨ09ｨｺ 08ｨ 0409ｨｨｨｰｨｨ07 00ｨｨ070208ｨ ｨｨ05ｨｨ08ｨｮｨ ｨｨｨｪ02ｨｬｨｨｨｨ [23, 26, 27]. 07 ｨｨｨｪ01ｨｨ09ｨｨ01ｨｮｨｮｨｬ0609, 070605ｨｮ ﾂｨ 06ｨｴｨｨ01 0008080406, 0708ｨｨ ｨｪｨ 05ｨｨ ﾂｨｨｨｨ ｨ 05 0502 0507 HLA-A*68 ｨｪｨ ｨ 0506 01ｨ 02ｨｰ 0907 0904 0906 ｨｺｨｨｨｦ 08ｨｨ09ｨｺ ｨ 09ｨｰ ｨｬｨ ｨｰｨｨ ﾂ02-09ｨｺｨｨ01 0609050603 ｨｪ02 ｨｪｨｨｨｦ, 09 ｨｰ06 090802ｨｬ07 ｨｺｨ ｨｺ ｨｮ 05ｨｨ02, ｨｨｨｬ02 06 ｨｴｨｨ01 ｨ 05 050205ｨｹ HLA-Cw*6, 03ｨ ｨｪ09 0706 05ｨｮ ﾂｨｨｨｰｨｹ ｨ 09ｨｰ ｨｬｨｮ ｨｪｨ ｨｬｨｪ06 0006 ｨｪｨｨ 0302 [12]. 0208ｨｮ 000602 0609050603 ｨｪ02 ｨｪｨｨ02 ｪ ｨｪ02ｨｦ ｨｰ0806 0702 ｨｪｨｨ07 ｪ 01ｨ 08ｨ ｨｺ ｨｰ02 08ｨｨ 04ｨｮ - 02ｨｰ0907 ｨｮ00080603ｨ 06ｨｴｨｨｨｬ 03ｨｨ04ｨｪｨｨ 090609ｨｰ0607ｨｪｨｨ02ｨｬ 09 09ｨｨ0102 ｨ 0409ｨｰ08060006 09ｨｪｨｨ0302ｨｪｨｨ07 ﾂｨｨ0905ｨ 02ｨｨ08ｨｺｨｮ05ｨｨ08ｨｮ06ｨｴｨｨ01 09 ｨｺ080609ｨｨ ｨｪ02ｨｦｨｰ080600ｨｨ050609; 0706 0802 04ｨｮ 05ｨｹ ｨｰｨ ｨｰｨ ｨｬ ｨｪ02 ｨｺ06 ｨｰ06 080401 070806 09020100ｨｪｨｪ0401 ｨｨ09 090502 0106 09ｨ ｨｪｨｨｨｦ ｨｪ02ｨｦｨｰ08060702ｨｪｨｨ07 ｨ 09090602ｨｨｨｨ08ｨｮ02ｨｰ0907 09 070605ｨｨｨｬ060800ｨｨ04ｨｬ06ｨｬ A1203A (rs11568695) 0002 ｨｪｨ MRP4 [4]. 07 ｨｰｨ ｨｺ06 0006 0609050603 ｨｪ02 ｨｪｨｨ07, ｨｺｨ ｨｺ 01ｨｨ09 05ｨｨ 07ｨｨ 0102 ｨｬｨｨ07, 01ｨ 08ｨ ｨｺ ｨｰ02 08ｨｨ - 04ｨｮ06ｨｴ0200060907 070609040302ｨｪｨｨ02ｨｬ 090601020803ｨ ｨｪｨｨ07 05ｨｨ07ｨｨ010609 09 ｨｺ080609ｨｨ 0006 ﾁ-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 07ｨ 02ｨｨ02ｨｪｨｰ0609, 0708ｨｨｨｪｨｨｨｬｨ 06ｨｴｨｨ01 08ｨｨ - ｨｰ06 ｨｪｨ 09ｨｨ08, ｨｬｨｪ06 00ｨｨ02 ｨｨ09 090502 0106 09ｨ ｨｰ02 05ｨｨ ｨｪｨ 0106 0107ｨｰ 09090704ｨｹ 09 0008ｨｮ07 0706ｨｦ 0002 ｨｪ0609 ﾂ02 0506 0902 ｨｺｨ : ABCA1, APOA5, APOC3, APOE ｨｨ CETP [5, 19]. 05ｨ ｨｺ0506 ﾂ02 ｨｪｨｨ02 08ｨ ｨｺ 09ｨｨ01 ｨｪ06 ｨｨ04 01ｨ ｨｪ ｨｪ0401 05ｨｰ06 0006 ｨｺ08ｨ ｨｰ ｨｺ06 0006 06ｨ 0406 08ｨ, 09 ｨｺｨ 03-0104ｨｬ 0006 0106ｨｬ 09ｨｰｨ ｨｪ06 09ｨｨｨｰ 0907 090900 06 ﾂ02 09ｨｨ01 ｨｪ0202 ｨｪｨ 05ｨｨ ﾂｨｨ02 09ｨｨ 05ｨｹ ｨｪ06ｨｦ 09090704ｨｨ ｨｬ020301ｨｮ 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 0008080406 ｨｮ 0006 ﾁ-ｨｨｨｪ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪ0401 ｨｨｨｪ01ｨｨ09ｨｨ01ｨｮｨｮｨｬ0609 ｨｨ 060906ｨ 02ｨｪｨｪ0609ｨｰ07ｨｬｨｨ 0002 ｨｪ06 ｨｬｨ ﾂ02 0506 0902 ｨｺｨ, ﾂｨｰ06 0706 040906 0507 02ｨｰ 0006 0906 08ｨｨｨｰｨｹ 06 0706 0709 0502 ｨｪｨｨｨｨ 09 09ｨｺ06 0806ｨｬ 090802 ｨｬ02 ｨｪｨｨ ｨｪ06 090401 ｨｬ02 ｨｰ06 010609 070806 00ｨｪ06 04ｨｨ 0806 09ｨ ｨｪｨｨ07, 0705ｨ - ｨｪｨｨ080609ｨ ｨｪｨｨ07, 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 ｨｨ 070609040302ｨｪｨｨ07 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 0008080406 09 ｨｮ ﾂ00ｨｰ06ｨｬ 05ｨｰｨｨ01 ｨ 09 0906 02ｨｨ ｨ 02ｨｨｨｦ. 00 01ｨ ｨｪ ｨｪ06ｨｬ 06ｨ 0406 0802 07080201 09ｨｰｨ 09 0502 ｨｪｨ 05ｨｨ03ｨｹ ｨｬｨ 05ｨ 07 ﾂｨ 09ｨｰｨｹ 0002 ｨｪ02 ｨｰｨｨ ﾂ02 09ｨｺｨｨ01 00ｨ ｨｺ ｨｰ06 080609 ﾂ02 0506 0902 ｨｺｨ, 06ｨｺｨ 0404 09ｨ 06 ｨｴｨｨ01 04ｨ ｨｬ02ｨｰ ｨｪ0602 0905ｨｨ 07 ｨｪｨｨ02 ｨｪｨ 070806 0709 0502 - ｨｪｨｨ02 0609050603 ｨｪ02 ｨｪｨｨｨｦ 0708ｨｨ 070806 0902 0102 ｨｪｨｨｨｨ 0008080406 ｨｨ 0200 0500 0002ｨｺ ｨｰｨｨ09 - ｨｪ0609ｨｰｨｨ. 0507ｨｨ0906ｨｺ 05ｨｨｨｰ0208ｨ ｨｰｨｮ0804 1. 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Za no ne P.B., Ri va A., Na si M. et al. Ge ne tic po ly mor p hisms dif fe ren t ly in f lu en cing the emer gen ce of at rop hy and fat ac cu mu la ti - on in HIV-re la ted li po dys t rop hy // AIDS. ｪ 2008. ｪ Vol. 22, 0114. ｪ P. 1769 ｪ1778. The in flu ence of hu man ge netic fac tors on HAART Tumanov A.S. The D.I. Ivanovsky In sti tute of Vi rol ogy of The Min is try of Health of The Rus sian Fed er a tion; 123098, Rus sia, Mos cow, Gamaleya str., 16; fax/phone: 8-499-1903063, e-mail: desep@mail.ru The re view dis cusses role of hu man ge netic fac tors in ef fi ciency and com pli ca tions of highly ac tive antiretrovirus ther apy (HAART). Ge netic poly mor phism of cytochrom P450 and multidrug re sis tance sys tems (spe cif i cally, CYP2B6 and MDR1/MRP1/P-gp, re spec - tively) af fects intracellular con cen tra tion of nu mer ous antiretroviral drugs (AD) that may ex plain dif fer ences in clin i cal ef fi cacy of HAART. Ge netic back ground might also im pact in rate of mis cel la neous com pli ca tions in pa tients re ceiv ing HAART. Thus hy per sen si - tiv ity to re verse tran scrip tase in hib i tors has been shown to be de pend ent on the pres ence of TNF al pha cytokine gene vari ant 308A or some al leles of HLA class I (HLA-B*5701, HLA-B*3505, HLA-B*14, HLA-Cw*4, HLA-Cw*8) or class II (HLA-DRB1*0101) loci. Pro tec - tion from lipodistrophia that rep re sents se ri ous com pli ca tion of HAART de pends on pres ence of par tic u lar al leles of poly mor phic cytokine genes IL-1, IL-18 and TNF beta. Vice versa, sus cep ti bil ity to en hanced trigleciride level fol low ing HAART is as so ci ated with polymorphic alleles of APOC3, ARb2, ARb3, HFE, LPIN1 and POLG loci whereas in creased risk of neu rop a thy is as so ci ated with ge - netic vari ants G516T and C983T of CYP2B6 gene. Var i ous com pli ca tions like hyperbilirubinemia,neutropenia and astma were found to be as so ci ated with UGT1A1*28 that con trols small lipophilic mol e cules, A1203A (rs11568695) of MRP4 and HLA-A*68, respectively. Data clearly dem on strates the need in per son al iza tion through ge netic pro fil ing in HAART to in crease its ef fi ciency and de crease the rate of complications. Key words: HIV-1, hu man ge netic fac tors, Highly Ac tive Antiretroviral Ther apy (HAART) ISSN 2073-7998 17