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9 2 PubMedoccupational &contact dermatitis&
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11 6 13 URL 6 7
12 PubMedoccupational & contact dermatitis ,000 2) 3) 4) 1 5) 6) 7) 8, 9) 10) 11) 12) 8
13 Cole DC et alcontact Dermatitis Penagos H et aldermatitis Guo YL et aloccup Environ Med Livesley EJ et aloccup Environ Med Berndt U et aldermatology Guo YL et alcontact Dermatitis Kuruvila M et alindian J Dermatol Venereol Leprol Wolf R et alj Toxicol Environ Health Aasmoe L et alcontact Dermatitis Jolanki R et alcontact Dermatitis
14 2 Matsunaga ) 10
15 1 1 11
16 ,511 1, % ,
17 1 16.2% 37.9% % 61.3% 2) Higashi 3) n1,733 13
18 4 1 n wet work 14
19 5 1 n610 6 n647 15
20 7 8 7 n n351 16
21 1 67.4% n n925 17
22
23 n
24 13 n n
25 % 15 n
26 2, 4, 5) % 16 n585 22
27 % % n
28 18 n % 9.5% 7.4% 2)
29 1 19 n794 25
30 20 n ) 26
31 21 22 n
32 23 5, 7, 8) 23 n694 28
33
34 25 30
35 PPD PTD ONPPD MAP PAP 31 1% pet. 25% pet. Brial 1% pet. Brial 1% aq. Brial 1% pet. Brial 1% pet. Brial CG 1% pet. Brial 0.2% pet. 0.01% aq. 0.5% pet. Brial Brial Brial 1% pet. Brial 1% pet. Brial 1% pet. Brial 1% pet. Brial 3% aq. 2% pet. Brial 2.5% pet. Brial 15 1% pet. Brial 1% pet. Brial 2% pet. Brial ATG CHC CAPB 2% pet. 1% pet. 1% pet. 1% pet. 1% EtOH/aq. Brial Brial 0.1% pet. 2.5% pet. Brial Brial Brial 1% pet. Brial 1% pet. Brial Brial PAAB 1% pet. Brial 8% pet. Brial 225 R-225 1% pet. Brial pet. aq. EtOH PPD
36 32 Brial Chemotechnique Brial 2 ICDRG % 9) as is 9) as is 9) 32 3 ICDRG Negative reaction Doubtful reaction Weak (non-vesicular) positive reaction Strong (vesicular) positive reaction Extreme positive reaction IR Irritant reaction of different types NT Not tested International Contact Dermatitis Research Group 32
37
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39 % 6 9.5% % 2 3.2%
40 %
41 % % 41.0% 3-5, 8, 10-15, 19, 30) 5, 10, 11) 4 /% 5 / / / / 6 2 / 23 4 / / 5 22 / / / 4 6 / 39 7 / / 5 33 / / / 3 2 / 30 2 / / 1 1 / 3 1 / / 9 2 / / 3 0 / 11 2 / / 3 0 / 1 0 / / 2 2 / / 1 1 / / 1 0 / 5 0 /
42 66.7% 35 3, 12) PPD % PPD 1 PPD 38
43 PAAB 74.0% 225 R % 2 PPD 8, 10, 13) PAAB PPD R-225 PPD PAAB PAP 9.8% PTD 7.8%PPD PTD 4560%PAP 3040% PPD 14) Higashi 3) 1 PPD PTD PAP PPD PPD 8, 15) PPD CAPB 42.0% CHC 18.0% 17.6% 14.0% 10.0% 10.0%CAPB CHC ATG 1 6.0%ATG 5, 16) ATG % ATG 10% CG CG 39
44 17) % 18) PPD 5 /% PPD 6 / 8 32 / / PTD 1 / 8 3 / 43 4 / / 8 2 / 43 3 / 51 ONPPD MAP 1 / 8 0 / 43 1 / PAP 1 / 8 4 / 43 5 / / 8 1 / 42 1 / / 8 0 / 42 0 / PAAB 5 / 8 32 / / R / 8 17 / / / 8 2 / 42 2 / / 8 7 / 42 7 / / 8 4 / 42 4 / / 8 1 / 42 1 / / 8 2 / 42 3 / 50 ATG / 8 2 / 42 3 /
45 CHC CAPB CG 15 0 / 8 9 / 42 9 / / 8 17 / / / 8 2 / 42 5 / / 8 3 / 42 3 / / 8 4 / 42 4 / / 8 2 / 42 2 / / 8 4 / 42 4 / / 8 0 / 42 0 / / 8 3 / 42 3 / / 8 1 / 42 1 / / 8 2 / 42 2 / / 8 2 / 42 2 / / 8 0 / 42 0 / / 8 2 / 42 2 / / 8 9 / 43 9 / / 8 3 / 43 3 / / 8 4 / 42 5 / PPD 75.0% 10.0% 37.5%- 8 1% 9) 41
46
47 PPD 3 37 PPD 92.0% PPD
48 8) PPD 225 PPD PPD PPD PPD CAPB PPDCAPB PPDCAPBPTD PPDCAPBPAP PPDCAPB PPDCAPB PPD PPDCAPB PPDPTD PPD PPDCHC PPD PPD CG PPD PPD CAPB PTD CHC PAP PPD
49 39 1 p-phenylenediamine; PPD PPDPPD PPD 8095% 3, 8, 10, 13, 19) 74.5% 92.0% PPD 45 p-phenylenediamine C 6 H 8 N
50 PPD 7 PPD PPD 8, 15) ) PPD 20) PPD PPD PPD PPD PPD ) PPD
51 7 29 PPD MAP PAP OAP PTD MPD % % % % % % % % % % % Cocamidopropyl betaine; CAPB CAPB % CAPB CAPB ) 3 CAPB CAPB CAPB 42.0%50 21 PPD 1 26) 41.0% CAPB 47 Cocamidopropyl betaine 22) O CH3 RCNH(CH 2 ) 3 + NCH 2 COO - RCO-represents the coconut fatty acid radical from C 11 H 23 to C 17 H 35CH3
52 CAPB CAPB 30.4% 39.0% CAPB CAPB Cysteamine hydrochloride; CHC CHC CHC ph CHC Cysteamine hydrochloride H 2 NCH 2 CH 2 SHHCl
53 1 CHC % CHC 2 27, 28) 1% pet. 28) 1 41 PPD CAPB 21.4% 42 9 CHC CHC CHC 3 as is 9) 41 CHC PPD CHC CHC 1% pet. 49
54 Nickel Nickel sulfate NiSO 4 Nickel sulfate Lynde 29) 26% 3, 5, 11, 12, 19) 10% 17.6% ) 4 3 5%
55 PPD 30) % pet. 51
56 1 31) 32) 21)
57 % 33) PPD 43 n12 44 n12 53
58 34) ) 25% 5) 5) 15) 45 n
59
60 35) Wet work PPD 1 PPD 56
61 5) 15) PPD 5) 15) 57
62 PPD 5) 58
63 5) 5) 5) 1 8, 15) 59
64 1 15) PPD 8) IgE RAST 60
65 PPD 5, 7, 8) 8) 5, 7) 7) ) 16.2% 37.9%
66
67 47 A
68 1Matsunaga K et alcontact Dermatitis Higashi N et alenvironmental Dermatology Visual Dermatology Journal of Environmental Dermatology and Cutaneous Allergology () Kato Y et alenvironmental Dermatology Xie Z et alenvironmental Dermatology () Heese A et al ()203, ( 14) Yasunaga C et alenvironmental Dermatology Hashimoto R et alenvironmental Dermatology Kondo M et alenvironmental Dermatology Isaksson M et alcontact Dermatitis Landers MC et alamerican Journal of Contact Dermatitis Lynde CW et alcontact Dermatitis Visual Dermatology
69 Nishioka K et alenvironmental Dermatology
70 )
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73 % % % % % % ) % % % % % % 6 1.8% 5 1.5% 2 0.6% 2 0.6%
74 ) % % % % % % 1, % % 1, % % % % % 6 1.8% % % % 5 1.5% % % 8 0.6% 2 0.6% 7 0.6% 2 0.6% 6 0.4% 0 0.0% 6 0.4% 1 0.3% 3 0.2% 1 0.3% 1, ) 70
75 % % % 28.7% 1) % % ) 71
76 6 CP % % ) %
77
78 7 3 1) % % %
79 %
80 % 7 1)
81 1) % % % % 1.9%
82 12 1)
83
84
85 % % 51.7 ± % %
86 ) ) 82
87 ) ) 1 3 2) 1) 1 83
88 ) 1)
89 ) % %
90 % 86
91 3) Ramazzini De Morbis Artificum Diatriba 4) ) 87
92 2 NACDGNorth American Contact Dermatitis Group 6, 7) 1993 EPIDERM Occupational Skin Disease Surveillance Scheme1996 OPRAOccupational Physicians Reporting Activity 8, 9) FIOHFinnish Institute of Occupational Health , 11) NSCNational Skin Centre 12, 13) NAVI ) 20 88
93 癤 89
94 ) 20 2) PCBPCDFPCDD [TCDD] 90
95 Pratt MD et aldermatitis Rietschel RL et alamerican Journal of Contact Dermatitis Meyer JD et aloccupational Medicine Cherry N et albritish Journal of Dermatology Kanerva L et alcurrent Problems in Dermatology Jolanki R et alcontact Dermatitis Goon AT et alcontact Dermatitis Loh TH et alcontact Dermatitis
96
æ æ2 \ R esults of Open Patch Tests in Control Solutions Containing Ammonium Thioglycollate or Cysteine Group Using Cold Permanent Wave 3 \ Results of
æ æ2 \ R esults of Open Patch Tests in Control Solutions Containing Ammonium Thioglycollate or Cysteine Group Using Cold Permanent Wave 3 \ Results of Patch Tests Using Cold Permanent Wave Solutions on
207 Nature,
30 The Long Fighting of America and Vietnam (1950-1975), 206 207 Nature, 208 Agent Orange, Dioxin and Consequences, 209 Science, 210 211 Nature 212 American Journal of Public Health, 213 Journal of Occupational
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2) Andrews and Domonkos: Hauseweives' eczma, Disease of the Skin 5 th Ed., Saunders, Philadelphia and London, 69, 19 63. 3) Pillsbury et al.: Dermtitis and Eczema of the Hands, Contact dermatitis, Dermatology,
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