Proceedings of the Society 78

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1

2 Proceedings of the Society 78

3 衆生無辺誓願度と遺伝学 IT IT

4 選考にあたって

5 MukB SMC DNA oric dif ParCEGyrA MukBMreB SetB MukB-AcpP AcpP-SecASecA-SecY SecA-SecB SecA-MreBMreB-SetBSecA-ParCEMreB-GyrA seqa DNA DNA seca acpp Par- GFP SecA ATPase SecA ATPase F SecA SecY POCPositioning of Chromosomes SecA SecA in vitro MukB AcpP mreb POC DNA. mm OM IM

6 M GSC ENU Gdf Japanese Skeletal Dyaplasia Consortium M Gdf Gdf dominant negative osteoarthrosisoa GDF brachydactyly type C OA OA M OA Storm, E.E. et al. Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily. Nature, -. Bobacz, K. et al. Cartilage-derived morphogenetic protein- and - are endogenously expressed in healthy and osteoarthritic human articular chondrocytes and stimulate matrix synthesis. Osteoarthritis Cartilage, -.

7 8 -oxog DNA-oxoG -oxo 8 -oxog -oxog

8 - DNA - - Tajima s D Hiramatsu, C., Tsutsui, T., Matsumoto, Y., Aureli, F., Fedigan, L. M. & Kawamura, S. Am. J. Primatol., -. Melin, A. D., Fedigan, L. M., Hiramatsu, C., Sendall, C. & Kawamura, S. Animal Behaviour, in press.

9 EEE E E E E Two-hybrid System Conditional Two-hybrid Screening T Cdc

10 DNA Rad Dmc RecA DNA Rad Swi Swi-Swi Swi-Sfr Swi-Swi Swi-Sfr Swi-Sfr Rad Rad-Rad Swi-Sfr Rad Rad Swi-Sfr RPA in vitro Rad DNA Rad DNA DNA Swi- Sfr Swi-Sfr Rad Rad ATP ATP DNA Swi-Sfr Swi-Sfr DNA Rad Swi-Sfr Rad DNA Swi-Sfr Rad Rad Rad Akamatsu et al. () Proc.Natl.Acad.Sci.USA () - Haruta et al. () Nat.Struct.Mol.Biol. () -

11 misfire(mfr) mfr mfr mfr C ferlin RT-PCR mfr Mfr Mfr m Mfr Mfr

12 Rim Gsdm Rim GsdmA Gsdm GSDMA GsdmA, A, A GsdmA GsdmA Rim GsdmA GsdmA GsdmC GsdmA GsdmC Gsdm Gsdm DDC Gsdm Rim 3 3 Rim Rim Gasdermin-A (GsdmA ) Rim Gsdm family (GsdmA, A, A, GsdmC, C, C, C, GsdmD)(GSDMA, GSDMB, GSDMC, GSDMD) GsdmA, A, A GsdmC, C, C, C GsdmAGsdmC GSDMA GSDMB

13 , XY K K K K DNA FISH XY K STS XX XY K XXY d Y d K XXY d K XXY d XYF K K F XXY d Y d BP 034 K : 034 Barscm 034 K 034 STS K

14 mechanotransduction StereociliaSC a, b SC WhirlinWhrn Whirlerwi cwi SC Whrn SC d Whrn WHRN PDZ Proline-rich cwhrn wi SC shakersh MyosinAMYOA SC SC e, f WHRN WHRN WHRN MAGUK Membrane-associated guanylate kinase p in vitro in vivo ap.r GlycophorinC p p SC b p.r c wi sh p.r wi sh d p.r WHRN MYOA SC WHRNp.R p.r WHRN SC A P stereocilia IHC, OHC, mb WhirlerWhrn wi Whrn wi SC WhrlinWhrn Whrn PDZ Proline-rich C PDZ CP Whrn wi StereocilamD, ESC WHRN AWHRN p WHRN PDZ p GUK p.r p HOOK.R FERM B p.r C SC Whrn wi shaker Myoa sh p.r

15

16

17 特別寄稿 遺伝学やバイオに関するシニア世代の高度な知識の活用 継承を実践するバイオ学部教育 について Collaborative Knowledge Discovery by Retired (?) Scientists and Young (?) Students. Retired(?)Scientists mailing list

18 mail Young(?)Students (?) mailing list mail t _ikemura@nagahama-ibio.ac.jp y_ yonemori@nagahama-i-bio.ac.jp cc GSJ - Tel-- Fax-- t _ikemura@nagahama-i-bio.ac.jp ü

19 BP 賞受賞一般講演一覧 Harvard Med. Sch. Dept. of Ecology and Evolution, Univ. of Chicago National Institute of Genetics,Center for Information Biology BRC Department of Biology, Duke University Department of Horticulture, University of Wisconsin-Madison, The Institute for Genomic Research, Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Institute of Genetics and Developmental Biology, China,

20 Dynamic NanoMachine Project, ICORP CREST Broad Institute of MIT and Harvard DDBJ GSJ Letterpress Co., Ltd. Japan 739_ _ FAX Genetics Society of Japan _ FAX 055_981_ _7_183404

82_4 GGS 2007... 3... 3... 3... 7... 8... 8... 9... 11... 11... 11... 12... 16... 16... 16... 17... 18... 18... 19... 19 2

82_4 GGS 2007... 3... 3... 3... 7... 8... 8... 9... 11... 11... 11... 12... 16... 16... 16... 17... 18... 18... 19... 19 2 Supplement to Genes Genet. Syst.(2007)82(4) GSJ Proceedings of the Society 大 会 会 長 挨 拶 ( 歓 迎 メッセージ) 大 会 総 合 案 内 大 会 日 程 表 創 立 1920 年 http://wwwsoc.nii.ac.jp/gsj3/index.html 82_4 GGS 2007... 3... 3... 3...

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