JSI Newsletter

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1 VOL.9 NO The Japanese Society for Immunology Newsletter URL; JSI Newsletter Printed in Japan Toshiyuki Hamaoka 30 6, Newsletter

2 21 Shigeo Koyasu JSI Newsletter Nature JSI NewsletterVOL.9 NO

3 Hiroshi Shiku 60 in vivo CD8 CTL MHCT 10 preventive preventive therapeutic fragile CD8 + CTL clinical grade CTL CD4 JSI NewsletterVOL.9 NO

4 Kyougo Itoh B1 SART BSART3 23 CTL HLA-A24 T 2 1 B B B ART SART JanewayTravers IgEIgG IgE HLA- A24 IgE IgG HLA-class 145 HLA 2CTL PBMC PBMCCTL1/ 20,000 CTL precursordirected peptide vaccine 14HLA-A24 17HLA-A2 PBMCCTL JSI NewsletterVOL.9 NO

5 Yutaka Kawakami URL: T HLA NCI10 trans-lational study GMP NCIRosenberg FDA informed consent volunteer HLA 10% 10% MHC JSI NewsletterVOL.9 NO

6 Toshitada Takahashi 1 Ovalbumin -galactosidase (surrogate) CTLCD4 TCR CTL susceptibility SCID SCID-hu HLA A24 in vivo in vitro MHCELISPOT CTLThin vivo 6 JSI NewsletterVOL.9 NO

7 Hamaoka Toshiyuki 1/41/3 P53, (concomitant immunity) IL-12 IL- 12 T IL-12T (stroma) ICAM-l VCAM-l T T IL-12 CCR5 CCR5MIP-1 MIP-1 T inside out LFA-1T modality SNP JSI NewsletterVOL.9 NO

8 Masaru Taniguchi 1 21 MHC T CTL DC CTL NKT NKT-GalCerCD1d NKT V14 CD1dMHC Ib MHCCTL NKT NKT MHC MHC MHC CTLMHC NKTCTL NKTCTL NK NK NKT NKTCTL MHC MHC MHC MHC MHC CTLNKT NKT-GalCer NKT 8 JSI NewsletterVOL.9 NO

9 Takashi Nishimura BCG IL-2LAKLymphokine-activated killer LAKNIH RosenbergInterleukininduced killerlak Boon Evidence-Base MedicineEBM EBM 5 21 EBM EBM 21 JSI NewsletterVOL.9 NO

10 Hideaki Tahara in vitro NCIDr. Rosenberg IL JSI NewsletterVOL.9 NO

11 20 Kazuo Sugamura , , Toll-Like Receptor Th 1 Th 2 NKNKT killing TLR Mucosal Allergy in vivo JSI NewsletterVOL.9 NO

12 21 Toshiyuki Hamaoka ()11 () B 3 4 5Th 1 /Th USJ 21 Presentation 12 JSI NewsletterVOL.9 NO

13 Fumihiko Matsuda Centre National de Genotypage 1984 V H 1Mb % C H V, (D), J V-(D)-J V H D 6 J H 6,000 Xeno mouse H L B H L V V H H V, D, J C H JSI NewsletterVOL.9 NO

14 Yousuke Takahama 10 NIHAlfred Singer Singer 11 V(D)J 14 JSI NewsletterVOL.9 NO

15 Toshinori Nakayama 3 NIHAlfred Singer 3 NIH meeting23 presentation presentation23alfred Singer native speaker discussion progrss entertainment enjyoyable NIHpostdoc1987NIH TCR/CD3 Lawrence Samelson Carl JuneAlfred Singer CD4 + CD8 + TCR discussion 3/5 T Singer JSI NewsletterVOL.9 NO

16 T Hiromichi Ishikawa Tintraepithelial T lymphocytesielcd3tcr- TCR IELT T CPIEL 1994 c-kit IEL c-kit+ CP c-kit+cp1,000 c-kit+cp1, CP 21G CP 0.13 mm 3 CP CP10 c-kit+lin c-kit+lin-cp 1,000CP c-kit+lin- CPIEL (-/-) IEL -/- -/-CP -/- -/-IEL -/- c-kit+lin-cp IELCP IEL 6CPIEL JSI Topics 100extraterrestrial 16 JSI NewsletterVOL.9 NO

17 Yoshimoto Katsura 1984 (p-t) p-t 10MLP (multilineage progenitor assay) MLP (M) MLPMTB p-t MLP 10 TCR 1984 TCR TCR TCR 10 7 MLPMTB3 p-p-mtb, p-mt, p-mb, p-tb, p-m, p-t, p-bp-tb 10p-T p-t p-tb stochastic modelrandom restriction model random restrictionp-tb p-tb random restriciton ordered restriction p-tb CLP(common lymphoid progenitor) p-tb CLPp-MTB p-mtbp-mt, p-mbp-t, p-b 21 JSI NewsletterVOL.9 NO

18 HOPE Noriko Sorimachi 35 motivationmotivation NK 2NK MHCI NK BT MHCI NK1MHCI germ line NKC: NK gene complex NKstochastic MHC I NKCproduct rule stochastic hierarchy NKMHCI 1 NK NK MHCIMHCI NK NK NK HP HP serendipity International Immunology URL: http// 18 JSI NewsletterVOL.9 NO

19 HOPE Takahiko Hara () URL: DNAX DNAX NCI AGM TEL FAX summer21@biken.osaka-u.ac.jp JSI NewsletterVOL.9 NO

20 Yoshiyuki Minegishi St.Jude 5 4 Physician-Scientist Student loan MCAT 10 NIH NIH PIPrincipal Investigator 50 PI preliminary data 1 peerreviewsignificance, Approach, Innovation, Investigator, Environment Environment Infrastructure 15 PhD MD Physician-Scientist 3 Love for Science B B JSI NewsletterVOL.9 NO

21 Pippa Marrackin vivo T Masaaki Murakami Howard Hughes Medical Institute, Department of Immunology, National Jewish Medical & Research Center URL; IL-6 gp130 Tom Pawlowski StaerzNational Jewish Medical and Research Center 11 TomJohn Kappler Pippa Marrack TOK 9 1 T 3 23 Pippa CDT 1992 CD8+T 6 Ph.D Chia-ChiPippa CD8+T 1999AhmedSwainT MHCTCR T CD8+TIL-2R CD8+T CFSEIL-2IL- 2RIL-2R CD8+T IL-2 CD8+T IL-2RSprent CD8+TIL-15 IL-2 IL-2T T CD8+TIL-2 IL-2CD8 T CD25+CD4+T IL-2 CD25+CD 4+T CD8+T RagKO TCD25+CD4+TCD8T CD8+T T TT NK B JSI NewsletterVOL.9 NO

22 CD8+T T T mkot T T CD4-CD8-T BMTT T gene mapping Pippa2 PippaJohnNJCHHMI Bursary Bursary Bursary A jsi@bcasj.or.jp JSI NewsletterVOL.9 NO

23 Tatsuo Kinashi Tim Springer Springer TLFA-1 T steel factor (stem cell factor)/c-kitvla-5 VLA-5PI-3 kinaseplc/pkc 2 PI-3 kinase PKC LFA-1 PI-3 kinasepkc, Rap1LFA-1 Rap1 Ras Rap1 2 JSI NewsletterVOL.9 NO

24 Kenji Izuhara 9 10DNAX IL-4 Jak/STAT IL-4 IL-4 IL-4/IL-13 IL-4/IL-13 IL SNP Th 1 /Th 2 Life Cycle 24 JSI NewsletterVOL.9 NO

25 Toshio Hirano 82 ( ) (15) ) ISI High-Impact Paper12 30ISI Honors Most Highly-Cited Authors in Japan) JSI Newsletter15 4 JSI Newsletter (2000/09/08) 7 (2000/09/11) 9 (2000/09/11) 10 (2000/09/14) 11 (2000/09/18) 12 (2000/09/19) 13 (2000/09/19) 14 (2000/09/25) 15 (2000/09/27) 16 (2000/09/27) /10/07) 18 (2000/10/23) 19 (2000/11/02) 20 (2000/11/02) /11/02) /12/24) JSI NewsletterVOL.9 NO

26 () ()21 () () () (),Watson () () () () () () JSI NewsletterVOL.9 NO

27 TEL/FAX kkato@phar.nagoya-cu.ac.jp TEL FAX yyokota@fmsrsa.fukui-med.ac.jp TEL: FAX: TEL: , FAX: , amatsuu@fujita-hu.ac.jp E- E- E tokuhisa@med.m.chiba-u.ac.jp JSI NewsletterVOL.9 NO

28 C O N T E N T S T HOPE Pippa Marrackin vivo T Printed in Japan 28 JSI NewsletterVOL.9 NO

JSI Newsletter

JSI Newsletter The Japanese Society for Immunology Newsletter URL;http://jsi.bcasj.or.jp/newpage1.htm C O N T E N T S 2 VOL.7 NO.2 VOL.7 NO.2 3 4 VOL.7 NO.2 VOL.7 NO.2 5 6 VOL.7 NO.2 VOL.7 NO.2 7 8 VOL.7 NO.2 VOL.7 NO.2