★保健医療科学_第67巻第2号.indb
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1 Vol. No.p., Recent deal trends in academic drug discovery in the US and Europe Hiromi Omoe 1), Noriaki Imanishi 2), Nobuyoshi Chiba 3,4), Ken J. Ishii 5) ) National Institute of Science and Technology Policy ) Department of Research Promotion, Japan Agency for Medical Research and Development ) Department of Innovative Drug Discovery and Development, Japan Agency for Medical Research and Development ) Laboratory of Vaccine Science, Immunology Frontier Research Center, Osaka University ) Laboratory of Adjuvant Innovation, National Institutes of Biomedical Innovation, Health and Nutrition Clarivate AnalyticsCortellis Deals Intelligence Deal Kasumigaseki, Chiyoda-ku, Tokyo -, Japan. Tel: -- omoe@nistep.go.jp [ ] 196
2 Abstract Objectives: The purpose of this study is to grasp recent global deal trends on academic drug discovery by comprehensively and quantitatively analyzing the deals between academia and industry in the US and Europe. Methods: During -, academic drug discovery deals in the US, the UK, France, Italy, and Spain were analyzed using Cortellis Deals Intelligence database provided by Clarivate Analytics Co., Ltd. Results: ) Total number of deals related to academic drug discovery was. Private sector company was a main buyer of the deals ( deals,. % of total deals) Most of the deals were licensing ( deals,. % of total deals). The deals showed the below characteristics. ) Oncology-related deals had the greatest percentage of total, followed by deals related to immunology-inflammation-vascular disease, diabetes, and peripheral and central nervous system diseases. ) Technology deals related to low molecular weight compound, diagnostics, and therapeutic antibodies were dominant and these deals accounted for % of total. ) Most deals were signed at the basic research and preclinical development stage. Recent deals tended to be dominantly signed at the basic research stage. ) Fifteen percent of total deals were signed with option. Conclusions: So far as the authors know, this paper presents the first comprehensive deal analysis about academic drug discovery and demonstrates overall trends in the US and Europe. keywords: academic drug discovery, deal, patent licensing (accepted for publication, st January ) I Japan Agency for Medical Research and Development AMED AMED [ ] [ ] [ ] [ ] Kneller [ ] [ ] FDA [, - ] Kneller [ ] [, ]Kneller [, - ] FDA 197
3 Deal Applied Biological Materials AMED [] Current Partnering [] Micklus[]Medtrack [] AMEDClarivate Analytics [] II AMED Clarivate Analytics Cortellis Deals Intelligence[] Cortellis Deals Intelligence Clarivate Analytics Thomson Reuters RECAP Cortellis Deals Intelligence Cortellis Deals Intelligence, Cortellis Deals Intelligence Cortellis Deals Intelligence.. Cortellis Deals Intelligence Exclusivity [ ] [ ] 198
4 .. Cortellis Deals Intelligence LicenseAsset purchase Joint Venture (Intellectual Property Only) Basic License License Option Collaboration Co-Development/Co-Development Option Cortellis Deals Intelligence. ) ). WHO ICD-[]FDA [] Cortellis Deals Intelligence Cortellis Deals IntelligencePrimary Therapeutic Area Cortellis Deals IntelligenceAsset Subtype Cortellis Deals Intelligence Cortellis Deals Intelligence Primary Technology. III
5 件 年 ジョイントベンチャー ( 戦略的提携 ) 資産買収 特許権使用許諾.... A - B - B-A /A A B A B AB A B B-A /A A A B B AB 200
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7 年 ( ) ライセンスオプション以外 * * 件 ( ) ライセンスオプション * 件 ( ) 年 ( ) ライセンスオプション以外 * * 件 ( ) ライセンスオプション * 件 ( )..... IV.. PharmaVenturesPharmaDeals, [,] 202
8 Micklus, [] FDA Stevens[ ] FDA NPO... [] Micklus [] -. Micklus [] Cortellis Deals Intelligence -. Cortellis Deals Intelligence Cortellis Deals Intelligence. [] Cortellis Deals Intelligence 203
9 [] Cortellis Deals Intelligence Micklus Medtrack PharmaVenturesPharmaDeals [,,,]. web Technology Licensing Organization, TLO Cortellis Deals Intelligence AMEDClarivate Analytics [] COI The authors have no competing interests. [ ] AMED.. -. p.. [ ] mhlw.go.jp/seisakunitsuite/bunya/kenkou_iryou/iryou/ shinkou/dl/vision_a.pdf (accessed --) [ ] Kneller R. The importance of new companies for drug discovery: origins of a decade of new drugs. Nat Reviews Drug Dis. ; : -. [ ]. iryou/shinkou/dl/vision_b.pdf (accessed -- ) [ ] Kaitin KI, Bryant NR, Lasagna L. The role of the researchbased pharmaceutical industry in medical progress in the United States. J Clin Pharma. ;: -. [ ] DiMasi JA, Hansen RW, Grabowski HG. The price of innovation: new estimated of drug development costs. J Health Economics. ;: -. [ ] Stevens AJ, Jensen JJ, Wyller K, Kilgore PC, Chatterjee S, Rohrbaugh ML. The role of public-sector research in the discovery of drugs and vaccines. N Eng J Med. ; : -. [ ] - / iinsiryou_.pdf (accessed --) [ ] medu-netamed amed.go.jp/news/event/forum.html (accessed --) [] Applied Biological Materials -.html (accessed --) [] Current Partnering. Global discovery stage partnering terms and agreements in pharma and biotech
10 (accessed --) [] Micklus A, Muntner S. Deal watch: Biopharma dealmaking : changing the pharma landscape. Nature Rev Drug Dis. ;:-. [] Medtrack. (accessed --) []. mext.go.jp/files/pdf/n_.pdf (accessed -- ) AMEDClarivate Analytics [] Clarivate Analytics. Cortellis Deals Intelligence. ip-science.thomsonreuters.jp/products/cortellis-di/ (accessed --) [] World Health Organization. ICD- Version:. apps.who.int/classifications/icd/browse//en#! (accessed --) [] U.S. Food and Drug Administration. Human Drug Advisory Committee. (accessed --) [] PharmaVentures. Approaches to valuation of pharmaceutical licensing deals. contents/sample_valuation.pdf (accessed --) [] PharmaDeals v. Discover the PhamaDeals v Agreements Database. (accessed --) [] Micklus A, Muntner S. Partnership deal activity in by phase of development. Nature Rev Drug Dis. ;(Suppl ). doi:./nrd... (accessed --) 205
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