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しょうりふじつぐ
9 years ago
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6 1) linisely, M. H. : Postburn Pathologic circulatory Physiology. F. A. Davis Co. philadelphia 1962, 2) James, G. W. et. al. : The anemia of thermal injury : Erythropoiesis and hemoglobin metabolism studied with N15-glycine in dog and man. J. din, Invest. 33, 150, ) *Wig*, ftit : IIIIMO 1 VI, ICU L CCU, 1, 277^-283, ) Harkins, H. N. : Experimental burns. Arch. Surg. 31, , ) Arturson, G. : Pathophysiological aspects of the burns syndrome with special reference to liver injury and alteration of capillary. Acta chir. Scand. Suppl. 274, , ) Wilson, W. C. : Extensive burns and scalds Edinburgh Med. J. 42, , ) Talaat, M. S. et. al, : Prevention of early histopathological changes in the liver in extensive burns. Br. J. Plast. Surg. 26, , ) Teplitz, C. : Pathology of burns, The treatment of burns. W. B. Saunders Co, ) Cameron, J. S. : Disturbance of renal function in burned patients. Proc. Roy. Soc. Med. 62, , ) Caldwell, F. T. et. al. : What constitutes the proper solution for resuscitation of the severely burned patients? Am. J. Surg. 122, , ) Achauer, B. M. et. al. : Pulmonary complications of burns : The major threat to the burn palient : Ann. Surg. 177, 311^-319, ) Morgan, A., Knight, D, and O'Connor, N. : Lung water changes after thermal burns, Ann. Surg 187, 288^-293, ) Rapaport, F. T. et. al. : Mechanisms of pulmonary damage in severe burns. 177, , Ann. Surg, 16) Pruitt, B. A. : Complications of thermal injury.

7 Current problems in surgery. 16, , ) Monato, W. W. : The treatment of burn shock by the intravenous and oral administration of hypertonic lactated saline solution J. Trauma 10 : 575^-586, 1970.

8 CRS0) Maltifactorial Analysis of Mortality in Severe Burned Patients - Observational Study during One Year Takaya Tanaka, Masanao MaKiura, Hiroshi Hosokawa, Toshie Yamagishi, Hideki Toikawa and Takao Chishiro Division of Emergency Medicine, Kansai Medical University, Moriguchi, Osaka, Japan Improvements in the management of the shock phase of severe burn and the development of topical agents for control of infection in the burn wound have significantly reduced the early post-burn mortality. Such advances have not, however, resulted in a dramatic overall decrease in mortality. We undertook an analysis of mortality and the many factors present on admission which we judged might influence mortality rates in our patients with severe burns. The study population consisted of the 14 burned patients, induced nine severe burns, from in-patient care at division of emergency medicine, kansai Medical University, during one year. After initial evaluation and emergency management, subsequent treatment included topical therapy, using porcine skin, silver salfadiazine cream, skin grafting as soon as possible, and occasionally early excision of third degree burns. Five in 9 severe burned patients did not survive with acute renal failure or septicemia. Nine severe burned patients had significantly decreased RBC, Ht, platelet count and total protein within 7 days more than other patients, and many cases of severe burned patients had became hepatic faire, pulmonary damage and DIC. In reviewing such factors in our patients, we think age, total burn area, third degree burn area, DIC, infection and multiorgan failure of pulmonary, liver and kidney as the factors present on admission which best distinguished survivors from non survivors.

CHEMOTHERAPY JUNE 1993 Table 1. Background of patients in pharmacokinetic study

CHEMOTHERAPY JUNE 1993 Table 1. Background of patients in pharmacokinetic study VOL. 41 S 1 Table 2. Levels (ƒêg/ml or ƒêg/g) of S-1006 in serum, bile, and tissue (gallbladder) after oral administration