Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII (45)

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2 Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII (45)

3 2306(46) THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 Dec.

4 Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII (47)

5 2308(48) THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 Dec.

6 Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII (49) Fig.2. Tissue concentration of intrapelvic genital organs after intravenous drip infusion of CTRX 1 g for 1 hour

7 2310(50) THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 Dec.

8 Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII (51) Fig.3. Tissue concentration of intrapelvic genital organs after intravenous drip infusion of CTRX 1 g for 30 minutes

9 2312(52) THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 Dec. Fig.4. Concentrations of CTRX in intrapelvic dead space exudate and concentrations required to inhibit 80% of clinical isolates (1g, i.v.) Table 4. Therapeutic results of CTRX

10 Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII (53) Table4. (Continued)

11 2314(54) THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 Dec. Table5. Clinical response to CTRX (1g x 2/day) Fig.5. Case 2, R.N., 31 y, 50 kg, Endometritis Fig.6. Case 3, Y.M., 36 y, 47 kg, Endometritis

12 Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 Fig.7. Case 4, K.T., 23y, 64kg, Endometritis Fig.8. Case 8, U.K., 20y, 60kg, Endometritis Fig.9. Case 13, T.Y., 40y, 51kg, Parametritis Fig.10. Case 5, K.M., 43y, 50kg, Endometritis, Adnexal abscess

13 THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 Dec. Fig.11. Case 6, Y.T., 34y, 78kg, Puerperal intrauterine infection Fig.12. Case 14, M.I., 26y, 60kg, Puerperal fever Fig.13. Case 1, T.O., 49y, 49 kg, Abdominal wall abscess

14 Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII (57) Table6. Bacteriological response to CTRX(1g ~2/day) Eliminated+Replaced/ Eliminated+ Decreased+ Unchanged+ Replaced

15 THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 Dec.

16 Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII-12 3) MCNAMARA, P. J.; K. STOECKEL & W. H. ZIEGLER : Pharmacokinetics of ceftriaxone following intravenous administration of a 3 g dose. Eur. J. Clin. Pharmacol. 22: 71 `75, ) ARISAWA, M.; J. OHSHIMA, E. OHSAWA, H. B. MARUYAMA, Y. SEKINE & S. MITSUHASHI: Bacteriological comparison of the activities of ceftriaxone, a new long-acting cephalosporin, with those of other new cephalosporins. Chem. Pharm. Bull. 30: 2544 `2554, 1982 PHARMACOKINETICS AND CLINICAL STUDIES ON CEFTRIAXONE IN THE FIELD OF OBSTETRICS AND GYNECOLOGY NANKUN CHO, HIROKO WATANABE, KIYOSHI YOSHIDA, SHUICHI MORIYAMA, HITOSHI TAKEDA and AKIMICHI TSUKAMOTO Department of Obstetrics and Gynecology, School of Medicine, Showa University Department KANGO FUKUNAGA of Obstetrics and Gynecology, Ohira Hospital KATSUAKI KUNII Department of Obstetrics and Gynecology, Kunii Hospital YOSHIHIRO KOMORIYAMA Department of Obstetrics and Gynecology, Fukushima Red-cross Hospital Ceftriaxone (Ro , CTRX), a new cephem antibiotic, was studied in the field of obstetrics and gynecology, and the following results were obtained. 1. The absorption and tissue penetration of CTRX into intrapelvic genital organs were good. The peak serum level in the uterine artery after a single intravenous injection and that after an intravenous drip infusion for minutes, both with 1 g, were pg/ml and pg/ml, respectively. High concentrations were obtained also in genital organ tissues; the maximum concentration was 93.8 pg/g by intravenous injection and pg/g by intravenous drip infusion. Changes in the tissue concentration were similar to those in the serum, the level over MICH against main pathogenic organisms being maintained for a long time. 2. The penetration of CTRX into intrapelvic dead space exudate was good. The level reached a peak of 18.8 pg/ml 2 hours after an intravenous injection with 1 g and 13.3 pg/ml after 12 hours, while the level over MIC80 against main pathogenic organisms was maintained for a long time. 3. CTRX was effective in 15 out of 16 cases (93.8%) with gynecoobstetric infections such as intrauterine, intrapelvic, adnexal infections, and postoperative wound infections, administered with 1 g twice a day. No side effects were observed.

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