VOL. 23 NO. 3 CHEMOTHERAPY 1379 Table 1 Susceptibility of clinical isolated strains to Tobramycin
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1 VOL. 23 NO. 3 CHEMOTHERAPY 1379 Table 1 Susceptibility of clinical isolated strains to Tobramycin
2 1380 CHEMOTHERAPY MAR Table 2 Susceptibility of isolated Pseudomonas aeruginosa to various antibiotics Fig. 1 Cumulative percentage of susceptibility to various antibiotics Isolated Pseudomonas aeruginosa : 84 strains
3 VOL. 23 NO. 3 CHEMOTHERAPY 1381 Fig. 2 Correlogram of MIC between Tobramycin and Gentamicin or DKB Staphylococcus aureus : 100 strains Fig. 3 Correlogram of MIC between Tobramycin and Gentamicin, DKB or Kanamycin E. coli: 100 strains Fig. 4 Correlogram of MIC between Tobramycin and DKB or Kanamycin Klebsiella sp. : 47 strains
4 1382 CHEMOTHERAPY MAR Fig. 5 Correlogram of MIC between Tobramycin and Gentamicin or DKB Pseudomonas aeruginosa : 84 strains Table 3 Blood levels after single intramuscular administration of Tobramycin and DKB to healthy volunteers
5 VOL. 23 NO. 3 CHEMOTHERAPY 1383 Fig. 6 Blood levels after single intramuscular administration of Tobramycin and DKB 40, 80mg dosis in the healthy volunteers Table 4 Urinary concentrations after intramuscular administration of Tobramycin and DKB to healthy volunteers,
6 1384 CHEMOTHERAPY MAR Table 5 Urinary excretions after intramuscular administration of Tobramycin and DKB to healthy volunteers Fig. 7 Urinary excretion after single intramuscular administration of Tobramycin and volun- DKB 40, 80 mg dosis in the healthy teers
7 VOL. 23 NO. 3 CHEMOTHERAPY 1385 Table 6 Urinary recoveries after intramuscular administration of Tobramycin and DKB to healthy volunteers
8 1386 CHEMOTHERAPY MAR Table 7 Foetal levels after intramuscular administration of Tobramycin to pregnant animals a) Blood levels in pregnant dogs b) Tissue concentrations in pregnant rabbits
9 VOL. 23 NO. 3 CHEMOTHERAPY 1387 Table 8 Clinical results of Tobramycin in gyneco-obstetrical fields Fig. 9 Ulcus vulvae M.O. 23 yrs. Female
10 1388 CHEMOTHERAPY MAR sment of the antibacterial activity of nebramycin factor 6. Antimicr. Agents & Chemoth. 5) MEYERS, B.R. & S.Z. HIRSCHMAN : Pharmacologic 6) KLASTERSKY, J. ; C. HENSGENS, A. HENRI & D. 1) Komi, K.F. & J.A. RHOADES : Structure of nebramycin factor 6, a new aminoglycosidic antibiotic. Antimicr. Agents & Chemoth. 309 `313, mycin and gentamicin. Antimicr. Agents & Che- moth. 5(2) : 133 `138, ) PRESTON, D.A. & W.E. WICK : Preclinical asses- 322 `327, ) MEYER, R.D. ; L.S. YOUNG & D. ARMSTRONG : Tobramycin (nebramycin factor 6) : In vitro activity against Pseudomonas aeruginosa. Appl. Microbiol. 22 (6) : 1147 `1151, ) BLACK, H.R. & R.S. GRIFFITH : Preliminary studies with nebramyin factor 6. Antimicr. Agents & Chemoth. 314 `321, 1970 studies on tobramycin and comparison with gentamicin. J. Clin. Pharmacol. 12 : 1972 DANEAU : Comparative clinical study of tobra-
11 VOL. 23 NO. 3 CHEMOTHERAPY 1389 STUDIES WITH TOBRAMYCIN KANJI SEIGA, MASAO MINAGAWA and Clinic of Gynecology and Obstetrics, NORIO FURUTA Kobe Central Hospital JUNKO MATSUSHITA Department of Clinical Laboratory, Kobe Central Hospital KUNIHIKO YAMAJI and YOKO SUGIYAMA Kinki Mothers and Children Infections Center Tobramycin, a new aminoglycoside antibiotic, was evaluated its value for clinical usefulness regarding antibacterial activity, distribution to body fluids and clinical response in the field of gynecology and obstetrics, and the following results were obtained: 1. Antibacterial activity of tobramycin against various organisms of 501 strains was determined. Minimum inhibitory concentrations of tobramycin were 1.56 Đg/ml or less against Staphylococcus aureus, 6.25 Đg/ml or less against Klebsiella sp., 1.56 to 3.12 Đg/ml of a sharp peak against E. coli and 12.5 Đg/ml or less against most strains of Pseudomonas aeruginosa. Tobramycin showed a most potent activity against Pseudomonas among the aminoglycoside antibiotics as gentamicin, DKB, BB-K8, kanamycin and colistin. 2. After intramuscular injection of 40 and 80 mg of tobramycin to adult volunteers, peak blood levels of 3.1 and 5.9 Đg/ml were obtained at 30 minutes and urinary recoveries of the two doses were about 50% for 12 hours. The result of cross over study of tobramycin with DKB showed similar pattern of absorption and excretion in two drugs. 3. In determination of the maternal-fetal transfer of tobramycin in aminals, peak level of maternal blood was 4 to 6 times higher than that of umbilical blood, and the distribution to fetal tissues was well proportional to the level of maternal blood. 4. A total of 20 cases of various infections in the field of gynecology and obstetrics was treated by tobramycin at daily dosage of 80 to 200 mg for 5 to 15 days. Although many of them were cases who did not respond to the prior antibiotic therapy, 11 cases showed satisfactory clinical response by the administration of tobramycin.
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