CHEMOTHERAPY SEPT. 1970
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1 CHEMOTHERAPY SEPT. 1970
2 VOL. 18 NO. 5 CHEMOTHERAPY
3 CHEMOTHERAPY SEPT. 1970
4 VOL. 18 NO. 5 CHEMOTHERAPY 691
5 692 CHEMOTHERAPY SEPT. 1970
6 VOL. 78 NO. CHEMOTHERAPY 5 写 真1 第1病 693 写 真4 日 In vitroの しCEZの 第22病 日 感 受 性 成 績 で はCoagulase陽 抗 一菌 力 はCERに 性 ブ菌 に対 や や 劣 る が,CEX,AB-PC よ り優 れ た 抗 菌 力 を 示 し た 大 腸 菌 に 対 し て はCERと ほ ぼ 同 程 度 の 抗 菌 力 で あ つ た が,肺 CEX,AB-PCに 炎 桿 菌 に は,CER, 比 べ 優 れ た 抗菌 力 を 示 した 吸 収 の 面 で はCEZ10mg/kg,20mg/kg,1回 に よ つ て,.[血 中 濃 度 ピ ー ク は1時 筋注 間 後 でStandardに 人 血 清 稀 釈 を 用 い た 場 合,そ の 値 は そ れ ぞ れ16.0mcg/ml, 40mcg/mlに 達 す る し か し濃 度 低 下 は 急 速 で,8時 間 後 に は 僅 か の 血 中 濃 度 を 示 す に す ぎ な い CER,CEZ 500mg1回 筋 注 時 の 血中 濃 度 を 比 較 す る と,血 ピ ー ク値 でCEZはCERの4.6倍 写 真2 第30病 日 はCERに 中濃 度 の 値 を 示 し た CEZ 比 し,蛋 白 結 合 率 は 高 く,第18回 日本 化学 療 法 学 会 総 会 シ ソポ ジ ウ ム で 清 水 に よ つ てCEZの 体液濃 度 測 定 条 件 に つ い て 報 告 が な さ れ た が,CERと の 比較 に は ま だ 問 題 が 多 い 排 泄 は き わ め て よ く8時 間 まで に平 均89.35%の 排泄 率 を示 した 臨 床 使 用 成 績 で は17例 中,著 効3例,有 の 不 適 症 例 を 除 け ば 有 効 率 は75%で て は 硬 結 の1例 効9例 で,1例 あつ た 副 作 用 と し を 除 け ば と くに み と め られ る よ うな も の は な か つ た な お 小 児 に お け る 使 用 量 に つ い て は1日50 100mg/kg2 3回 の 分 割 筋 注 が 望 ま1い 文 1) 鳥 居 敏 雄,川 拡 散 法)に 写 真3 第1病 す 以 上 小児智 領 域 に お い てCEZの 績 を述 べ た ひ 献 上 保 雄,小 島 碵 夫:重 層 法(一 よ る ペ ニ シ リ ン定 量 法 に つ い て ペ ニ K. KARIYONE; H. HARADA, M. KURITA and T. TAKANOCefazolin, a new semisynthetic 基 礎 的 臨 床的 検 討 成 次元 シ リ ソ1(5): ,1948 日 2) む と考 え る halosporin antibiotic. mical properties I. Synthesis of Cefazolin. Cep- and che- J. Antibiotics
7 CHEMOTHERAPY SEPT , , ) M. NISHIDA; T. MATSUBARA, T. MURAKAWA, Y. MINE, Y. YOKOTA, S. GOTO and S. KUWAHARA : Cefazolin, a new semisynthetic Cephalosporin antibiotic. II. In vitro and in vivo antimi - crobial activity. J. Antibiotics 23 : , ) M. NISHIDA; T. MATSUBARA, T. MURAKAWA, Y. MINE, Y. YOKOTA, S. Goro and S. KUWAHARA Cefazolin, a new semisynthetic Cephalosporin antibiotic. III. Absorption, excretion and tissue distribution in parenteral administration. J. Antibiotics 23 : , ) Y. MINE ; M. NISHIDA, S. GoTo and S. KUWAHARA Cefazolin, a new semisynthetic Cephalosporin antibiotic. IV. Antigenicity of Cefazolin and its cross reactivity with Benzylpenicillin, Ampicillin and Cephaloridine. J. Antibiotics 23 : , 1970 LABORATORY AND CLINICAL STUDIES OF CEFAZOLIN IN PEDIATRIC FIELD TADAFUMI NISHIMURA, YASUSHI KOTANI & YASUNORI ASATANI Department of Pediatrics, Osaka Medical College The authors have carried out the laboratory and clinical studies of Cefazolin. The results were as follows; The sensitivity was measured by the plate dilution method with 59 strains of Staph. aureus, 30 strains of E. coli and 13 strains of Klebsiella isolated from patients. The growth of 54 strains of Staph. aureus was inhibited at concentrations of less than 1.56 mcg/ml. The growth of 20 strains of E. coli was inhibited at concentrations of less than mcg/ml, and 8 strains of Klebsiella, at less than mcg/ml. Cefazolin was given in a single intramuscular dose of 10 and 20 mg per kg. b. w. to two children, respectively. The maximum blood level was reached at 1 hour after administration. The levels were 16.0 mcg/ml and 40.0 mcg/ml, respectively. The excretion rate of Cefazolin in the urine after a single intramuscular dose of 20 mg per kg. b. w. was % up to 8 hours of period. Cefazolin was administered intramuscularly or intravenousely at a daily dose of mg per kg. b. w. to 17 children with bacterial infections. Cefazolin was effective in 12 cases of them. As a side effect, induration was observed in one case.
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