3, ,104 t mg/l 30 mg/l BOD mg 14 C 8, /kg 11 8, 1 11 OH = cm 3 / sec 11 OH /cm ppm

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1 3, CAS , 3-4, , 3 - H 2 N Cl Cl NH 2 C 12 H 10 C l2 N , > kg/m = kpa mmhg log Pow m/z 252, Koc , 3 - / 3.1 mg/l 4 2

2 3, ,104 t mg/l 30 mg/l BOD mg 14 C 8, /kg 11 8, 1 11 OH = cm 3 / sec 11 OH /cm ppm = , Av µg/l µg/l Lepomis macrochurus Leuciscus idusmelanotus 610 Chlorella fusca var. vacuolata 940

3 3, ppb ppb ppm B/A B/A B/A B/A 54 0/ / B/A 4. LC 50 mg/l EC 50 mg/l * 13 : Scenedesmus h: 2 subspicatus 5 Daphnia magna h: 2 Lepomis macrochirus 5 Pimephales promelas h h Brachydanio h rerio 5 * OECD , 15 1 LD 50 LC 50 LD 50 7,070 mg/kg 3,820 mg/kg >8,000 mg/kg 100 mg/kg

4 3, mg mg/kg mg/kg/ 100 mg// 6 3 / 5 / 7.1 ALT mg 15L 23,700 mg/m 3 2 / * In vitro In vivo TA98TA1538 S9 +/- 11 DNA TA100TA1535S TA98TA100TA1538 S9 +/- 15 WP2S9-4 S9 +/- 4 S9 + HeLa S M 11, 15 ICR 1,000 mg/kg ,000 mg/kg mg/kg DNA ,000 mg/kg * mg/kg

5 3, ICR , 11, 15, 17 Rappolovo mg// 6 / g/ 8, 11, 15, 17 ShR-CD 50 mg/kg/day , 11, 15, , , 11, 15, mg/kg/ 100 mg// 6 3 / 5 / 7.1 8, 11, 15, mg/ mg/ 1 8, 11, 15 3 BALB/c 2 mg// , 15, mg/day mg/m µg/l µg/cm 2

6 3, µg/cm , 19, 20 3 EPA 1999 EU 1998 B2 2 NTP 2000 * IARC B ACGIH 2000 A B 3, , , 20 4 ACGIH

7 3, C 1 g mg/ mg/kg mg mg/kg 11 1 g mg DNA 11 DNA DNA S9 mix DNA DNA 8-24 DNA DNA OECD * 5 1 * OECD OECD

8 3, in vitroin vivo IARC 2B OH in vitroin vivo

9 3, , ) The Merck Index, 12th. Ed., Merck & Co., Inc Sharat Gangolli, The Dictionary of Substances and their Effects, 2nd. Ed., The Royal Society of Chemistry IUCLID International Uniform Chemical Information Data Base Data Sheet, EU C Log P,. 7 NIST Library of 54K Compounds. 8 Hazardous Substances Data Bank HSDB, U.S. National Library of Medicine ,,, BUA Report, , OECD, Harmonised Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures, OECD Series on Testing and Assessment No AQUIRE US EPA, ECOTOX Database System. 15 IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Integrated Risk Information System IRIS, U.S. Environmental Protection Agency JETOC,,, ACGIH, Booklet of the Threshold Limit Values and Biological Exposure Indices ,, 41,

10 mg/l h h h h h LC 50 EC AQUIRE US EPA, ECOTOX Database System. 2 IUCLID International Uniform Chemical Information Data Base Data Sheet, EU 1995.

11 3, 3-11 : ICR : /5 8/8 2/21 18/18 : 50 mg/kg/day 50 mg/kg/day 1-4 ShR-CD 0.1 : /44 9/44 0/44 7/44 0/44 8/44 Beagle BALB/C 3/44 26/44 : 100 mg// 100 mg// mg/kg/ : 3 / 6, 0/6 4/4 5 / 7.1 0/6 3/4 : mg// 5 2mg// 6/30 13/24 0/30 7/ , 3, 4 1 IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Hazardous Substances Data Bank HSDB, U.S. National Library of Medicine Integrated Risk Information System IRIS, U.S. Environmental Protection Agency BUA Report,

12 3, month d

,309 t 22,069 t 7,240 t µg/l µg/l < ,431-70, , , mg/l m

,309 t 22,069 t 7,240 t µg/l µg/l < ,431-70, , , mg/l m 1 20019 1527 CAS 1317368 1230 PbO 223.20 1 99 1. 2 888 2 9.53 0.017 g/l 20 3 3 2 2. 10 29,309 t 22,069 t 7,240 t 4 1 3. 1 2 3.5 6 1 µg/l 9.1-24 2 µg/l < 43 6 27,431-70,000 4.5-1,300 13.4-17 31.7 0.48-3,459