EHC / EHC 1-8) WHO/IPCS CICAD (Concise Inter
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- ふみな うづき
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1 3 [ ] Priority IARC JMPR Priority 1 Priority 1 Priority 2 Priority 3 Priority 1 1-1) CERI) eet&sort=cas&page=1 1-2) CERI) ( ) (NITE) 2005/ ) ( ) 1-4) ) / ) OECD SIDS SIDS Initial Assessment Report 2004/ ) WHO/IPCS EHC2005/9 No.1~No.231
2 EHC / EHC 1-8) WHO/IPCS CICAD (Concise International Chemical Assessment Documents) CICAD Executive Summary ) ACGIH Documentation of the threshold limit values for chemical substances (7 th edition, 2001) 690 TLVs and BEIs ACGIH 1-10) (DFG) Occupational Toxicants Critical Data Evaluation for MAK Values and Classification of Carcinogens Vol List of MAK and BAT values DFG 1-11) EU Risk Assessment Report 2005/ DOCUMENT RISK ASSESSMENT ) Assessment Report Environment Canada Priority Substance Assessment Reports 2005/9 66 Australia NICNAS Priority Existing Chemical Assessment Reports 2005/9 No.1~No.26 ( ) ) European Center of Ecotoxicology and Toxicology of Chemicals(ECETOC) Technical Report 100 JACC Report 1-14) Patty s Toxicology (5 th edition, 2001) 1-15) WHO IARC IARC Monographs Programme on the Evaluation of Carcinogenic Risk to Humans, of Data reported and Evaluation IARC 1-16) EPA Integrated Risk Information System IRIS ) NTP NTP Database Search Home Page: [For Standard Toxicology & Carcinogenesis Studies, Reproductive Studies, Developmental Studies, Immunology Studies, Genetic Toxicity Studies] Study Results & Research Projects Study Data Searches
3 Report on Carcinogens: Public Health Report on Carcinogens 11 th RoC (The 11 th RoC contains 246 entries, 58 of which are listed as known to be human carcinogens and with the remaining 188 being listed as reasonably anticipated to be human carcinogens.) Study Results & Research Projects NTP Study Reports / Long-term TR1~TR ) p , 2004 EHC CICAD IARC WHO (1) (2) (1) (2) Priority 2 2-1) NIOSH RTECS (156,000 ) 2-2) WHO/IPCS ICSC International Chemical Safety Cards (1,400 ) priority 1 priority 2 ex.htm IPCS 2-3) EU European Chemicals Bureau (ECB) International Uniform Chemical Information Database (IUCLID) (2,000 ) IUCLID CD-ROM (Update Edition ) 2,600 IUCLID 2-4) EU Annex 29 Annex European Chemicals Bureau ECB SEARCH CLASSLAB 2-5) HSDB: Hazardous Substance Data Bank ) ATSDR: Toxicological Profile
4 2-7) Hazardous Substance Fact Sheet (New Jersey Department of Health and Senior Services): 2-8) Sittig s Handbook of Toxic and Hazardous Chemicals and Carcinogens (4 th edition, 2002) 2-9) German Chemical Society-Advisory Committee on Existing Chemicals of Environmental Relevance: BUA Report 230 full report 2-10) Dreisbach s Handbook of Poisoning (13 th edition, 2002) Priority 3 MSDS GHS 3-1) Pub-Med/NLM NLM TOXNET TOXLINE JICST ( ) JOIS 3-2) ( ) GESTIS-database on hazardous substances (BIA) ( ) WebKis-Plus Priority GLP Priority
5
6 [ ] A) (mg kg) a (mg kg) 50 a (ppm) 100 a, b mg L 0.5 a, b c, d 0.05 (mg L) a,b,e 5000 (f) (a) LD50 LC50 ATE (b) (c) (d) 1(100ppm) 2(500ppm) 3(2500ppm) 4(5000ppm) : ( ) ; : ( ) ; : 1µm 100µm (e) OECD (f) 5 LD mg kg 5 (i) LD50 (LC50) 5
7 5 (ii) B) N.A. C) Priority GLP Priority RTECS NIOSH D) EU Annex I
8 ( ) GHS mg/kg EU-R phrase R28 25 R R ( ) GHS mg/kg EU-R phrase R27 50 R R ( ) GHS mg/l EU-R phrase R R R20 20 UNRTDG E) (ppm) mg/l ppm mg/l 1 ( ppm ) mg/l ( mg/l) ppm mg/kg LD A
9 A) 3 1 ( ( ) ) 1A 3 1 1B 1C (1) ( 2) 72 ( 3 ) (2) 2 14 (3) ( 3) 72 ( B) GHS Draize OECD 435 in vitro membrane barrier test method MSDS Severe, Moderate, Mild EU Annex R-Phrase R34 R35 R38 R36/37 R36/38 R37/38 R36/37/38 C) Priority GLP Priority
10 D) EU Annex I R34 R35 C EU Annex I R38 R-Phrase R36/38 R37/38 R36/37/38 Xi E) Severe, Moderate, Mild Severe 2 Corrosive Severe Moderate Mild + GHS 1(1A,1B,1C) 2 3 ph 2 ph 11.5
11 A) B) GHS Draize MSDS Severe, Moderate, Mild EU Annex R-Phrase R36 R41 R36/37 R36/38 R36/37/38 C) Priority
12 GLP Priority D) EU Annex I R41 EU Annex I R36 R-Phrase R36/37 R36/38 R36/37/38 E) Severe, Moderate, Mild Severe Corrosive Severe Moderate Mild + GHS 1 2A B
13 A) B) C) Priority EU Annex R42 R43 R42/43 ACGIH TLV SEN Sensitization MAK Sensitization Sa Sh Sah GLP Priority D) EU Annex I R-Phrase R42 R43 R42/43 ACGIH TLV SEN DGF MAK Sa Sh Sah
14 E) EU Annex R42 R42/43 EU Annex R43 R42/43 ACGIH SEN ACGIH Documentation
15 A) - in vivo - in vivo in vivo - in vitro - in vivo - in vitro in vivo - in vitro 2 B) in vitro in vivo In vitro in vivo GHS in vitro in vivo
16 1A in vivo 1B in vivo in vivo DNA UDS in vivo in vivo in vivo DNA USD SCE in vitro in vitro in vitro in vitro 1A 1B 2 GHS (1) in vivo (OECD478) (OECD485) (2) in vivo (OECD475) (OECD484) (OECD474) (3) in vivo (a) (OECD483) (b) (SCE) DNA (UDS)
17 (4) in vivo DNA (UDS) (OECD486) (SCE) (5) In vitro (OECD473) (OECD476) (OECD471) C) in vitro in vivo GHS in vitro 2 in vivo D) EU Annex GHS E) EU Annex R46 1A EU Annex R46 1B EU Annex R68 EU MAK
18 A) 1 ( ) 2 B) WHO IARC EU Annex NTP ACGIH TLVs and BEIs EPA Integrated Risk Information System IRIS DFG List of MAK and BAT Values [3-1] C) Priority IARC EU US EPA US NTP ACGIH DGF
19 GLP Priority D) IARC EU Annex GHS E) 1A 1B GHS 1A IARC EU Annex R45, R49 US EPA A US NTP ACGIH A1 1B IARC 2A EU Annex R45, R49 US EPA B1 US NTP B ACGIH A2 IARC 2B EU Annex R40 US EPA B2 ACGIH A3
20 A) 2 (a) (b) (c)
21 B) CERI EHC ECETOC SIDS C) Priority EU GLP Priority D) EU Annex GHS E) 1A 1B EU Annex R60, R61 1A EU Annex R60, R61 1B EU Annex R62, R63 EU Annex R64
22 A)
23 B) MSDS EU Annex R39 R48 R-Phrase C) Priority EU R-39 R-48 GLP Priority D) E) GHS
24 GHS 3 GHS (RTI) 3 GHS
25
26 A) 1 1 (a) (b) mm 2 /s mm 2 /s B) C) Priority Priority D)
27 E) A) (mpas) / (g/cm 3 ) = (mm 2 /s)
3, ,104 t mg/l 30 mg/l BOD mg 14 C 8, /kg 11 8, 1 11 OH = cm 3 / sec 11 OH /cm ppm
3, 3-1 200019 4800 CAS 91941 1138 3, 3-4, 4 - -3, 3 - H 2 N Cl Cl NH 2 C 12 H 10 C l2 N 2 253.13 1 95 1. 2 3, 4 132-133 402 5 >200 5 700kg/m 3 5 8.73 = 1 5.610-8 kpa 4.210-7 mmhg20 4 6 log Pow3.51 3.57
,309 t 22,069 t 7,240 t µg/l µg/l < ,431-70, , , mg/l m
1 20019 1527 CAS 1317368 1230 PbO 223.20 1 99 1. 2 888 2 9.53 0.017 g/l 20 3 3 2 2. 10 29,309 t 22,069 t 7,240 t 4 1 3. 1 2 3.5 6 1 µg/l 9.1-24 2 µg/l < 43 6 27,431-70,000 4.5-1,300 13.4-17 31.7 0.48-3,459
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1 982 2207 CAS 67630 2- H 3 C H 3 C CH OH C 3 H 8 O 60.10 1 99.9 % n- 1. 2-88.5 3 82.5 3 11.7c.c. 455 4 212 d 20 4 0.78505 3 2.1 = 1 4 4.4 kpa 33 mmhg20 4 log Pow0.05 0.07 5 m/z45, 1.0 43 0.19 27 0.17
,977 t 157,977 t mg l mg l BOD 9398 % OH = cm 3 / sec 11 = cm 3 / sec OH = /
1 9625 2219 CAS 75569 1, 2-1, 2- H 2 C CH CH 3 C 3 H 6 O 58.08 1 99 % 1. 2 2, 3-112.13 2, 3 34.23-37 449 2.8-37 % 2 d 0 4 0.859 4 d 20 0.8304 2 2, 4 2.00 = 1 53.33 kpa 400 mmhg18 59.33 kpa 445 mmhg20 5
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1 2001 7 1 543( ) CAS 1309 64 4 1 25 ( ) Sb 2 O 3 291.52 1) 99 1. 2) 655 3) 1,425 3) ( ) 2) ( ) 2) ( ) 2) 5.2 ( ) 5.67 ( ) 3) 2) 2. 10 12,161 t ( 9,753 t 2,408 t) 4 2 1) 3. 1) 2) 3) 4. Selenastrum capricornutum
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16 19 19 19 150 1960 15 H. W.T.G. 16 QOL 16 298 16 297 16 7 20 17 4 1 FDA CDRH MDR MAUDE AERS MedWatch WebKis-Plus KIS-NET EU WHO(IPCS ) INCHEM CICADS EHC NLM TOXNET EPA IRISATSDR NTP EU ECB Food Standard
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(1) 1,2- DMP CAS 131-11-3 C 10 H 10 O 4 194.2 2 1) 5.5 2,3) 283.7 2,3) 1.192 (20 ) 4) 133 Pa (1 mmhg) (20 ) 5) 1ppm=7.94 mg/m 3 at 25, n- / 1.56 ( ) 6) 4) ( )3.2 (30 ph 7)11.6 (30 ph 9)25 (18 ph 9) 5)
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1 ( ) DBDPO CAS 1163-19-5 C 12 Br 10 O 959.2 2 1) 305 2) 3.0 1) 1- / (logp ow ) 1) 5.03 mmhg306 1) 1) 3) 4) 5) 1.010-4 6) mg/l25 3 7) OH 8) 4 9) 6 BOD 0% 14 100 mg/l 30 7) 10) BCF 5 < 42 60 mg/l 7) 50
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