278 Dementia Japan Vol. 32 No. 3 September F BC : F : F : F :

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1 F : F : Peter J. Whitehouse Transdisciplinary Professor, Case Western Reserve University and University of Toronto F : George Perry Dean and Professor, Semmes Foundation Distinguished University Chair in Neurobiology College of Sciences, The University of Texas at San Antonio, San Antonio, TX F A :

2 278 Dementia Japan Vol. 32 No. 3 September F BC : F : F : F : F A : 24

3 F BC : F : F : F : F A : Tsuneya Ikezu Boston University School of Medicine, Boston, Massachusetts, United States 25

4 280 Dementia Japan Vol. 32 No. 3 September F BC : F : F : F : F : 26

5 F : F : F : F : F : 27

6 282 Dementia Japan Vol. 32 No. 3 September F : F : F : F : F : 28

7 F : F : F : F :

8 284 Dementia Japan Vol. 32 No. 3 September F A : ips / 1. ; 2. in vitro trial ips microrna F BC : BPSD β F : 1. Aβ 2. Aβ p3 - Alcβ 30

9 β 4. Aβ KLK7 5. Aβ F : BPSD 3. BPSD 4. BPSD AI Nursing F :

10 286 Dementia Japan Vol. 32 No. 3 September F : F A : 1. Glymphatic system MRI α F BC : 1. : 2. Risk and protective factors for dementia in a community : the Hisayama Study 32

11 β F : 1. Factors Important to the Development of New Alzheimer s Disease Therapies Biogen Inc. Samantha Budd Haeberlein 2. First step toward disease modification in AD - targeting beta amyloid and tau proteinopathies Global Head of Neurodegeneration and AD Franchise Head PD Neuroscience F. Hoffmann - La Roche Ltd. Rachelle S. Doody 3. BACE1 Inhibitor CNP520 in the Alzheimer Prevention Initiative API Generation Program Global Program Head, Neuroscience, Novartis Pharma AG Ana Graf 4. The role of amyloid and tau PET imaging in therapeutic clinical trials for Alzheimer s Disease Vice President of Imaging, Avid Radiopharmaceuticals a wholly owned subsidiary of Eli Lilly Michael D. Devous 5. Clinical Development for Early Alzheimer s Disease Based on the Amyloid Hypothesis Neurology Business Group, Eisai Inc., Wood Cliff Lake, NJ, USA Johan Luthman 6. Clinical Studies in Asymptomatic Subjects at High Risk for Alzheimer s Disease AD Janssen Research and Development, Fremont, California, USA John Thipphawong F : / 1. / 2. TMG 3. 33

12 288 Dementia Japan Vol. 32 No. 3 September F : F : Aβ APOE and TREM2 as key microglial molecules for neurodegenerative phenotypes in Alzheimer s disease Boston University School of Medicine, Boston, Massachusetts, United States Tsuneya Ikezu F A : 1. 34

13 D 4. NPO F BC : NTT 1. ICT NTT Cognitive Assessment for Dementia, ipad version 2 CADi F : 1. :

14 290 Dementia Japan Vol. 32 No. 3 September F : : 3. : F : Cnm Streptococcus mutans F A : 1. progress pitfall : MRI 2. SPECT 36

15 MIBG 4. DAT F BC : 1. : F : 1. WPI - IIIS

16 292 Dementia Japan Vol. 32 No. 3 September F A : F BC : F : 1. DNA 2. TDP

17 RNA 4. RNA RAN F : F A : 1. Primary age - related tauopathy PART 2. Argyrophilic grain disease 3. Cerebral age - related TDP - 43 pathology and arteriolosclerosis CARTS 4. SNAP PET 39

18 294 Dementia Japan Vol. 32 No. 3 September F BC : 1. DLB 2. DLB 3. DLB pitfall 4. DLB F : mrna F :

19 F : 1. treatable dementia : F : 1. REST : KEAP1 - NRF2 41

20 296 Dementia Japan Vol. 32 No. 3 September F : 1. TDP Aβ : 20 15:20 1F : : F : : : AD ADL BPSD Cognitive function AD ABC AD 42

21 F A : : : PMDA GLP, non - GLP GMP STR STR F BC : / : : 1 kg 1-1.5% 1 neurovascular unit, NVU NVU small vessel disease F Sponsor : Chugai Pharmaceutical Co., Ltd. : Hiroyuki Arai Institute of Development, Aging and Cancer, Tohoku University : Rachelle Doody Global Head of Neurodegeneration, F.Hoffmann - La Roche Ltd. One of the greatest areas of unmet need remaining in medicine is the need for disease modifying drugs for congenital and chronic neurological diseases. At Roche, we are targeting Multiple Sclerosis ; Neurodegenerative disorders, including Alzheimer s disease, Parkinson s disease, Huntington s disease, and Amyotrophic Lateral Sclerosis ; Neuromuscular diseases, especially Spinal Muscular Atrophy ; and the Neurodevelopmental disorder, Autism. Our approach to each disease is driven by the extent of our scientific understanding of these diseases, and our belief that the intervention is potentially transformational. In MS, we believe that treatments targeting B Cells are able to affect all forms of the disease, both relapsing remitting and chronic progressive. For Alzheimer s and Parkinson s disease, we target the proteinopathies of these diseases with monoclonal antibodies. For the rapidly progressive disorder, ALS, we target the pathway involved with cell death. For the genetic disorders of SMA and HD, we utilize gene modifying therapies, and our approach to Autism is based upon the neuroendocrine targets known to be associated with social behaviour. The ultimate goal is to provide lasting and impactful therapies for these disorders. 43

22 298 Dementia Japan Vol. 32 No. 3 September F : : 1. : 2. : / TEA F : / : : Aβ Aβ MCI J - ADNI Aβ F : : : 44

23 F : / : : Alzheimer AD MCI AD A N T AD - MCI A - N+ SNAP suspected non - AD pathophysiology - MCI AD AD F A : : : BPSD BPSD BPSD BPSD AMED BPSD F BC : : : AD 45

24 300 Dementia Japan Vol. 32 No. 3 September F : : : Alzheimer s disease : AD disease - modifying drug : DMT β Aβ DMT Semagacestat β solanezumab 3 AD DMT F : EPD : : QOL F : : : BPSD 46

25 F : IQVIA : : β β F : : : AD AD NMDA AD AD F A : : : 47

26 302 Dementia Japan Vol. 32 No. 3 September F BC : : : DLBPD PD 7 25 mg DLB DLB F : RI : : 6 DLB Cinglate Island Sign CIS EBM F : : : 48

27 F : : : frailty F A : MSD : : F : : : 49

28 304 Dementia Japan Vol. 32 No. 3 September F : : : AD BM AD Aβ42 t - p - BM BM AD BM F Sponsor : Eli Lilly Japan K.K. : Michael D. Devous Vice President, Avid Radiopharmaceuticals, Inc F A : : / : : DLB DaT - SPECT 50

29 F : : : Alzheimer Alzheimer F : / : : AD DLB VaD FTLD DLB DLB DLB DLB F : : : MS MS MS MS 51

30 306 Dementia Japan Vol. 32 No. 3 September β 002 APP Aβ Kallikrein - related peptidase CA1 005 The analysis of APP βctf - mediated vesicle traffic impairment PET 18F PM - PBB3 010 FUS AT N system 013 β : 014IMR 015IMR 016 AD continuum THK

31 Logopenic PET 018 Nationwide survey on cerebral amyloid angiopathy in Japan Department of Neurology and Neurobiology of Aging, Kanazawa University Kenji Sakai 019 β 020 Proximity Ligation Assay Aβ β Aβ : 022 β β O - Force 025 β Catalytide O - Force 026 APPswe/PS1dE9 027 In vitro β 028 seed Aβ 029 β 030 β 031 Expression of APP770 in normal and Alzheimer s disease brains 032 γ 033 Iron - treatment enhances γ - secretase activity and inhibits amyloid depostion 034 β - amyloid precursor protein APP processing 53

32 308 Dementia Japan Vol. 32 No. 3 September γ p3 Alcβ - AD 036 Glycosylation deficiency of nicastrin induces cleavage defect of γ - secretase 037 p3 - Alcβ37 p3 - Alcβ Aβ42 oligomer p3 Alcβ PKA PKC Aβ : 042 CD14 and Toll - like receptor 4 promote fibrillar Aβ uptake by microglia through clathrin - mediated pathway Department of Neurology, School of Medicine, Sapporo Medical University Fujikura Mai 043 :Aβ 044 PSEN1 045 : α FKBP12 - immunopositive inclusions in patients with α - synucleinopathies 050 WPI - IIIS 051 α 54

33 X11L ApoE4 053 apolipoprotein E Aβ dynamics 054 Regulation of expression and release of ApoE in cultured astrocytes 055 ApoE ips 056 Effect of lactoferrin on ApoE secretion from cultured astrocytes Nagoya City University Medical Sciences Biochemistry Jung CG 057 APOE2 promotes longevity ; a clinical and preclinical assessment 058 Apolipoprotein E 059 APOE 060 APOE APP : 061 2N3R Tau C DPAA Tau 066 Rho - ROCK

34 310 Dementia Japan Vol. 32 No. 3 September Aβ ILEI/FAM3C 072 Aβ ILEI TREM APP Alcadein α 077 Phosphorylation of Alcadeinα is required for kinesin - 1 association Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University Anqi Hu 078 RNA 079 Precision Medicine 080 CJD - V180I C9 - ALS/FTD 083 Rubicon 084 APP NL - G - F 085 AD 086 A new generation of human - close Alzheimer s disease rat model AgenT

35 VS 089 Analysis of phospholipid species in AD model mouse brain by LC - MS/MS Haque MD MSC transplant decreases Aβ and increases angiogenesis in Aβ - infused rats Sheikh Abdullah Fibril - inoculated alpha - Synuclein BAC Tg mice 098 α 099 Tau protein induced neural impairment in tauopathy mice : tau PET and H - MRS study 100 mglur5 PET rtg Silencing of FUS in the marmoset caudate induces disruption of fiber tracts Effect of TRF on memory, proteome profile, and amyloid pathology in APP/PS1 mice Hamezah Hamizah Shahirah Bifidobacterium breve A1 106 Shiga - Y5 Aβ 57

36 312 Dementia Japan Vol. 32 No. 3 September Alcadeinβ p3 Alcβ - Aβ NMDA 109 β 110 α 111 Nose - to - Brain New therapy of Alzheimer s disease and schizophrenia based on D - cell hypothesis Dept Psychiatry, Iwaki Kyoritsu Gen Hosp Ikemoto Keiko β C 120 Characterization of the selective binding properties of crenezumab Genentech, Inc., a member of the Roche Group William Meilandt 121 Identification of alprenolol as an anti - prion compound using SPRi 122 B ApoE E4 C : 124 MCI 58

37 US - ADNI 126 β 127 Immuno Magnetic Reduction AD, MCI Aβ42 Tau 128 Cerebrospinal fluid and blood biomarkers in neurological diseases 129 Aβ 130 p - Tau PSEN1 Zhu Bin RNA 136 AD mirna DNA 140 Alzheimer tauopathy extended CENSUS 59

38 314 Dementia Japan Vol. 32 No. 3 September JBBN : α IMP - SPECT Cingulate Island Sign 150 AD DLB ECD - SPECT CIS core 151 IMP - SPECT CIScore DLB AD 152 Scenium 123I - FP - CIT SPECT DAT - SPECT parkinsonism SPECT 158 JCHO 60

39 HDLS 160 CSF1R 161 AARS2 162 MRI Gerstmann - Sträussler - Scheinker GSS Common neurologic and psychiatric symptoms as initial manifestations of CJD 166 E200K Creutzfeldt - Jakob disease 167 V180I 168 MM1 MM2 scjd MRI 169 MM2 Creutzfeldt - Jakob 170 MRI 171 Creutzfeldt - Jakob 172 Sporadic CJD with codon 129 valine homozygosity and cerebellar peduncle lesions :

40 316 Dementia Japan Vol. 32 No. 3 September : 178 : bapwv MRI HDL 185 : Cognitive Function Instrument CFI 62

41 Mild cognitive impairment tau 203 Lewy Lewy 3 204/ PET 205 Dementia praecox An 84 - year - old female case of mixed dementia complicated with NPH Yuki Asahara MELAS 63

42 318 Dementia Japan Vol. 32 No. 3 September MRI Deep Learning 214 SPECT 215 The effect of aging on the CBF by 123I - IMP SPECT in normal subjects and AD 216 SPECT cingulate island sign F - PM - PBB3 PET F - AV45 PET amnestic MCI AD 220 AD continuum THK THK5351 PET 222 PiB - PET 223 PiB PET SUVR PADRE PiB Incretin s Neuroprotective Effect 64

43 ; Aβ Alzheimer 236 Aβ : Aβ 237 Aβ Aβ 238 Safety and pharmacokinetics of crenezumab in Mild - to - Moderate AD patients Genentech, Inc. Helen Lin 239 Phase I Clinical Study of Crenezumab in Japanese Patients with AD 240 Logopenic progressive aphasia Chinese letter 242 Pisa syndrome induced by switching donepezil to galantamine

44 320 Dementia Japan Vol. 32 No. 3 September preclinical AD / JCHO 251 ABC 252 MMSE 253 FCSRT MR 254 DLB 255 DLB : mg 258 Noise Pareidolia Test Pure Autonomic Failure with Lewy bodies

45 REM sleep without atonia : VOSP 266 GDS β FAB 272 3T MRI CHADS2 R2CHADS MCI

46 322 Dementia Japan Vol. 32 No. 3 September Yokukansan for BPSD : Meta - Analysis of Randomized Controlled Trials 280 & NTT : MCI Safety and Tolerability of Gantenerumab High - dose Open Label Extension Study F. Hoffmann - La Roche Ltd Danielle Abi - Saab 298 Amyloid Pet Results of Gantenerumab High - dose Open Label Extension Studies Roche Pharma Research and Early Development Gregory Klein 68

47 BPSD 303 ADHD 304 ADL IADL 308 DBD BPSD Q 311 BPSD HDS - R MOCA - J MCI 314 Cognitive Performance of the User experience - Trail Making Test UX - TMT MCI 69

48 324 Dementia Japan Vol. 32 No. 3 September MMSE MoCA - J MCI AD AD - ADL MCI MMSE 324 MRI default mode net work 325 NMR 326 AD DLB 327 MCI ECD - SPECT MRI & 70

49 ; 338 Wernicke 99mTc - ECD SPECT 339 Alzheimer 340 ; 341 ; 342 : face to face 71

50 326 Dementia Japan Vol. 32 No. 3 September , MSW EA :

51 BPSD ADL CDR DASC DASC - 21 AD MCI 73

52 328 Dementia Japan Vol. 32 No. 3 September : 390 DBD DBD : 393 ADL MSW

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