dvi

Size: px

Start display at page:

Download "dvi"

けいざぶろうふしはら
5 years ago
Views:

1 Vol. 18, No ) reactivation/replay 2) 3 5) 21 6) Mac UNIX g Long-Evans SR-8N 13 g C&B F2.0 II M1 2mm 7) reference ground bregma lambda V head-restraint (1) (2)

2 (3) (4) (5) 7) freely-moving (1) (2) (3) 8) Brain-Machine Interface 3. 4 tetrode 9) 2A A-M Systems # µm 50 cm 2B Polymicro Technologies TSP µm cm 2C 2D GC electronics Silver Print 2E MΩ 2% mv 10) S/N µm David Kopf Neuro-Hyperdrive 2F Neuralynx Harlan Drive 8) 100 µm/

3 16 Vol. 18, No A B C D E F David Kopf Instruments Hyperdrive 1.5 mm mm Neuralynx Harlan 12 Drive 12 11) silicon probe NeuroNexus mm µm 15 µm 25 µm 3A 100 µm 16 10) 1 0 µm 800 µm 150 µm 1,200 µm 8 3B 7) NeuroNexus LFP8+TetrodeSD1 IC 3C SCAT 12) 4 4 Texas Instruments TLC2274CN CD IN(+) IN( ) OUT New England Wire N28-36E B voltage

4 17 3 A NeuroNexus 16ch 2 4 B C 4 A TLC IN( ) OUT B 16ch IC 4 R G follower ±4.8 V 4 2 5A 1 DC 5B 4. 1,000 2, Hz 10 khz MEG-6116 (+) ( ) E S 5B 1kHz Hz 10) µv TEAC LX khz 16 bit ±5V GB dat

18 Vol. 18, No. 1 2011 5 A B R G E S 6 1 2 3 KlustaKwik EToS 5.

5 18 Vol. 18, No A B R G E S KlustaKwik EToS 5. spike detection feature extraction clustering 3 13) Hz 5kHz S/N principal component analysis PCA PCA3

6 KlustaKwik K. Harris Classification EM CEM 13) Rutgers Buzsáki 14) t 15) EToS FIR PCA EM 16) CPU MacPro 2.93 GHz Quad-Core Intel Xeon 2 2GB 8 UNIX 1 6. Buzsáki Klusters autocorrelogram ACG cross-correlogram CCG 14, 17) Klusters 2 2 7A 0ms 1ms 7B e 1ms 7A a +b EToS 7C f+g 2 monosynaptic excitation 3 common driver 2 3, 7) MATLAB Buzsáki NeuroScope 14, 17) 7.

7 20 Vol. 18, No A Klusters a b c a b c a b ACG ±1ms a c b c CCG 1 a b B e C f g 4ch > 1ch > 3ch > 2ch 18, 19) G. Buzsáki K. Harris

8 21 1) Buzsáki, G. (2004): Large-scale recording of neuronal ensembles, Nat. Neurosci., Vol.7, No.5, pp ) Foster, D.J. and Wilson, M.A. (2006): Reverse replay of behavioural sequences in hippocampal place cells during the awake state, Nature, Vol.440, No.7084, pp ) Toyama, K., Kimura, M., and Tanaka, K. (1981): Cross-correlation analysis of interneuronal connectivity in cat visual cortex, J. Neurophysiol., Vol.46, No.2, pp ) Kobayashi, T. et al. (1997): Task-dependent representations in rat hippocampal place neurons, J. Neurophysiol., Vol.78, No.2, pp ) Sakurai, Y. (1994): Involvement of auditory cortical and hippocampal neurons in auditory working memory and reference memory in the rat, J. Neurosci., Vol.14, No.5, pp ) multineuron resource/index.html 7) Isomura, Y. et al. (2009): Microcircuitry coordination of cortical motor information in selfinitiation of voluntary movements, Nat. Neurosci., Vol.12, No.12, pp ) Takahashi, M. et al. (2009): A code for spatial alternation during fixation in rat hippocampal CA1 neuron, J. Neurophysiol., Vol.102, No.1, pp ) Gray, C.M. et al. (1995): Tetrodes markedly improve the reliability and yield of multiple single-unit isolation from multi-unit recordings in cat striate cortex, J. Neurosci. Methods, Vol.63, No.1-2, pp ) Isomura, Y. et al. (2006): Integration and segregation of activity in entorhinal-hippocampal subregions by neocortical slow oscillations, Neuron, Vol.52, No.5, pp ) Yamamoto, J. and Wilson, M.A. (2008): Large-scale chronically implantable precision motorized microdrive array for freely behaving animals, J. Neurophysiol., Vol.100, No.4, pp ) Townsend, G. et al. (2002): Recording and marking with silicon multichannel electrodes, Brain Res. Brain Res. Protoc., Vol.9, No.2, pp ) Harris, K.D. et al. (2000): Accuracy of tetrode spike separation as determined by simultaneous intracellular and extracellular measurements, J. Neurophysiol., Vol.84, No.1, pp ) html 15) Takekawa, T. et al. (2010): Accurate spike sorting for multi-unit recordings, Eur. J. Neurosci., Vol.31, No.2, pp ) 17) Hazan, L. et al. (2006): Klusters, NeuroScope, NDManager: a free software suite for neurophysiological data processing and visualization, J. Neurosci. Methods, Vol.155, No.2, pp ) 2008,, Vol.15, No.3, pp ) 2010,, Vol.17, No.3, pp

passive passive active 1 ( ) LTP 1 1) 2) 1 1

11 8 25 passive passive active 1 ( ) LTP 1 1) 2) 1 1 1997 CA1 12 13 1990 2 K A K 1997 transient 3 transient 4-aminopyridine 4- AP A K A A [ 1 conductivity recording transient 4 ] 2 ( K ) i) A K CA1 A K