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1 Review Streptomyces verticillus Streptomyces verticillus Molecular mechanisms for bleomycin resistance : sugi(c~hiroshima-u.ac.jp

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8 1) Umezawa, H., Maeda, K., Takeuchi, T., Akami, Y. : J. Antibiot., 19, (1966) 2) Stubbe, J., Kozarich, J. W. : Chem. Rev., 87, (1987) 3) Sugiyama, M., Thompson, C. J., Kumagai, T., Suzuki, K., Deblaere, R., Villarroel, R., Davies, J. : Gene, 151, (1994) 4) Sugiyama, M., Kumagai, T., Shionoya, M., Kimura, E., Davies, J. E. : FEMS Microbiol. Lett., 121, (1994) 5) Sugiyama, M., Kumagai, T.. Matsuo, H., Bhuiyan, M. Z. A., Ueda, K., Mochizuki, H., Nakamura, N., Davies, J. E. : FEBS Lett.. 362, (1995) 6) Umezawa, H., Takeuchi, T., Hori. S., Sawa, T., Ishizuka, M., Ichikawa, T., Komai, T.: J. Antibiot., 25, (1972) 7) Umezawa, H., Hori, S., Sawa, T., Yoshioka, T., Takeuchi, T. : J. Antibiot., 27, (1974) 8) Sebti, S. M., DeLeon, J. C., Lazo, J. S. : Biochemistry, 26, (1987) 9) Sebti, S. M.. Mignano, J. E., Jani, J. P., Srimatkandada, S., Lazo. J. S.: Biochemistry, 28, (1989) 10) Bromme, D., Rossi, A. B.. Smeekens, S. P., Anderson, D. C.,

9 Payan, D. G. : Biochemistry, 35, (1996) 11) Kambouris, N., Burke, D. J., Creutz, C. E. : J. Biol. Chem., 267, (1992) 12) Magdolen, U., Muller, G., Magdolen, V., Bandlow, W. : Biochim. Biophys. Acta, 1171, (1993) 13) Enenkel, C., Wolf, D. H.: J. Biol. Chem., 268, (1993) 14) Xu, H. E., Johnston, S. A.: J. Biol. Chem., 269, (1994) 15) Joshua-Tor, L.. Xu, H. E., Johnston, S. A., Rees, D. C. : Science, 269, (1995) 16) Zheng, W., Johnston, S. A., Joshua-Tor, L. : Cell, 93, (1998) 17) O'Farrell, P. A., Gonzalez, F., Zheng, W., Johnston, S. A., Joshua-Tor, L. : Structure, 7, (1999) 18) Kumagai, T., Muta, K., Matoba, Y., Kawano, Y., Kamiya, N., Davies, J., Sugiyama, M. : Acta Crystallogr. Sect. D, 54, (1998) 19) Kawano, Y., Kumagai, T., Muta, K., Matoba, Y., Davies, J., Sugiyama, M. : J. Mol. Biol., 295, (2000) 20) Kumagai, T., Hibino, R., Kawano, Y., Sugiyama M. : FEBS Lett., 450, (1999) 21) Sugiyama, M., Kumagai, T., Hayashida, M., Maruyama, M., Matoba, Y. : J. Biol. Chem., 277, (2002) 22) Mazodier, P., Cossart, P., Giraud, E., Gasser, F. : Nucl. Acids Res., 13, (1985) 23) Kumagai, T., Nakano, T., Maruyama, M., Mochizuki, H., Sugiyama, M.: FEBS Lett., 442, (1999) 24) Kumagai, T., Maruyama, M., Matoba. Y., Kawano, Y., Sugiyama, M. : Acta Crystallogr. Sect. D, 55, (1999) 25) Maruyama, M., Kumagai, T., Matoba, Y., Hayashida, M., Fujii, T., Hata, Y., Sugiyama, M. : J. Biol. Chem., 276, (2001) 26) Wu., W., Vanderwall, D. E., Tuner, C. J., Kozarich, J. W., Stubbe, J. : J. Am. Chem. Soc., 118, (1996) 27) Yuasa, K., Sugiyama, M.: FEMS Microbiol. Lett., 132, 61-66(1995) 28) Yuasa, K., Kumagai, T., Ohta, Y., Sugiyama, M. : J. Ferment. Bioeng.. 84, (1997) 29) Kumagai, T., Sugiyama, M. : J. Biochem., 124, (1998) 30) Elmileik, H., Kumagai, T., Berengena, M., Ueda, K., Sugiyama, M. : J. Biochem., 129, (2001) RIKEN Genomic Sciences Center Genome Exploration Research Group Genome Function and Technology Exploration Team Researcher : Bioinformatics (System Biology) The RIKEN Genome Exploration Research Group, Genomic Sciences Center in Yokohama is developing strategic technologies for high-throughput gene-function identification starting from the full-length cdna technology and the derived mouse fulllength cdna collection "the Mouse Genome Encyclopedia". The Genome Function and Technology Exploration Team has proceeded high-throughput analysis of protein-protein interactions (PPI) and developed "the PPI Network Viewer" to grasp the major PPI networks visually, therefore other large-scale data of our group including sequencing information, chromosomal mapping information, and gene expression information, is closely linked. The team has also developed "the Interaction Generality Method" to estimate the reliability of each interaction computationally and also gives priority to discover and apply bioinformatics methods for the PPI analysis and the integrated data analysis. The following position, under the supervision of Dr. H. Suzuki is immediately available. Researcher : Bioinformatics (System Biology) The successful candidate will establish a key strategy and system for bioinformatics methods to analyze the PPI data and the PPI-based integrated data. He/She will develop the key programs and subsequently apply them broadly on biological problems selected from signal transduction, neurobiology, mouse model of human pathologies or structural biology. The qualifications required are Ph. D. (or equivalent) in Bioinformatics, Computational Biology, Computer Science or a related field with strong knowledge of Structural Biology, Molecular Biology, and Genomics. The applicants with experience in Natural Language Processing, Applied Mathematics and Physics, or a related field, who have intensive interest in Bioinformatics research, will also be considered. The ability of programming (Unix with programming skills in Perl, Java or C/C++ is required.), fluency in English will be essential. He/She should be proactive, highly motivated, and have a positive attitude, sense of humor in a stimulating, interactive, open communicative research environment in RIKEN. Conditions The laboratory wishes to offer competitive conditions and focuses on personal growth, which is a must. Applications (in English or Japanese), including a CV, a list of publications, a statement of his/her own research interest, should be mailed to : Dr. Akiyama RIKEN Genomic Sciences Center Genome Exploration Research Group Suehiro-cho. Tsurumi-ku, Yokohama-city Kanagawa , JAPAN http ://genome.gsc.riken.go.j p/

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