|
|
|
- まとも たかぎ
- 7 years ago
- Views:
Transcription
1 Kazumitsu Ueda, [Department of Applied Life Science, Kyoto University Graduate School of Agriculture, Kitashirakawa, Sakyo-ku, Kyoto , Japan] Molecular Mechanisms for Drug Transport by MDR1/P-glycoprotein
2
3
4
5
6
7
8 1) Gottesman, M. M., Pastan, I.: Annu. Rev. Biochem., 62, (1993) 2) Ueda, K., Kino, K., Taguchi, Y., Yamada. K., Saeki, T., Tanigawara, Y., Komano, T.: in Multidrug Resistance in Cancer Cells : Cellular, Biochemical, Molecular and Biological Aspects
9 (ed. Gupta, S., Tsuruo, T.), pp , John 22) Kino, K., Taguchi, Y., Yamada, K., Komano, T., Wilev & Sons (1996) Ueda, K. : FEBS Lett, 399, (1996) 23) Helvoot, A. V., Smith, A. J., Sprong, H., Fritzsche, 4) Juliano, R. L., Ling, V. : Biochim. Biophys. Acta, 455, (1976) 5) Inaba, M., Kobayashi, H., Sakurai, Y., Johnson, R. K. : Cancer Res., 39, (1979) 6) Ueda, K., Pastan, I., Gottesman, M. M.: J. Biol. Chem., 262, (1987) 7) Chen, C.-J., Chin, J. E., Ueda, K., Clark, D. P., Pastan, I., Gottesman, M. M., Roninson, I. B. : Cell, 47, (1986) 8) Ueda, K., Cornwell, M. M., Gottesman, M. M., Pastan, I., Roninson, I. B., Ling, V., Riordan, J. R.: Biochem. Biophys. Res. Commun., 14, (1986) 9) Ueda, K., Cardarelli, C., Gottesman, M. M., Pastan, I.: Proc. Natl. Acad. Sci. USA, 84, (1987) 9a) Kioka, N., Ueda, K. et al.: Biochem. Biophys. Res. Commun., 162, (1989) 10) Loe, D. W., Deeley, R. G., Cole, S. P. C. : Eur. J. Cancer, 32A, (1996) 11) Zhang, J. T., Duthie, M., Ling, V.: J. Biol. Chem., 268, (1993) 12) Beja, O., Bibi, E.: J. Biol. Chem., 2705, (1995) 13) Ueda, K., Shimabuku, A. M., Konishi, H., Fujii, Y., Takebe, S., Nishi, K., Yoshida, M., Beppu, T., Komano, T. : FEBS Lett., 330, (1993) 14) Schinkel, A. H., Kemp, S., Dolle, M., Rudenko, G., Wagenaar, E.: J. Biol. Chem., 268, (1993) 15) Georges, E., Tsuruo, T., Ling, V.: J. Biol. Chem., 268, (1993) 16) Kast, C., Canfield, V., Levenson, R., Gros, P. : Biochemistry, 34, (1995) 17) Loo, T. W., Clarke, D. W.: J. Biol. Chem., 271, (1996) 18) Loo, T. W., Clarke, D. W.: J. Biol. Chem., 271, (1996) 19) Chen, C.-J., Clark, D., Ueda, K., Pastan, I., Gottesman, M. M., Roninson, I. B.: J. Biol. Chem., 265, (1990) 20) Smit, J. J. M., Schinkel, A. H., Oude Elferink, R. P. J., Groen, A. K., Wagenaar, E., van Deemter, L., Mol, C. A. A. M., Ottenhoff, R., van der Lugt, N. M. T., van Roon, M. A., van der Valk, M. A., Offerhaus, G. J. A., Berns, A. J. M., Borst, P. : Cell, 75, (1993) 21) Ruetz. S.. Gros, P. : Cell, 77, (1994) I., Schinkel, A. H., Borst, P., Meer, G. V. : Cell, 87, (1996) 24) Hettema, E. H., van Roermund, C. W. T., Distel, B., van den Berg, M., Vilela, C., Rodrigues- Pousada, C., Wanders, R. J. A., Tabak, H. F. : EMBO J., 15, (1996) 25) Homolya, L., Hollo, Z., Germann, U. A., Pastan, I., Gottesman, M. M., Sarkadi, B. : J. Biol. Chem., 268, (1993) 26) Greenberger, L. M.: J. Biol. Chem., 268, (1993) 27) Akabas, M. H., Kaufmann, C., Cook, T. A., Archdeacon, P. : J. Biol. Chem., 269, (1994) 28) Shimabuku, A. M., Nishimoto, T., Ueda, K., Komano, T. : J. Biol. Chem., 267, (1992) 29) Sharom, F. J., Yu, X., Doige, C. A.: J. Biol. Chem., 268, (1993) 30) Urbatsch, I. L., Sankaran, B., Weber, J., Senior, A. E. : J. Biol. Chem., 270, (1995) 31) Taguchi, Y., Yoshida, A., Takada, Y., Komano, T., Ueda, K. : FEBS Lett., 401, (1997) 32) Urbatsch, I. L., Sankaran, B., Bhagat, S., Senior, A. E.: J. Biol. Chem., 270, (1995) 33) Hirai, M., Tanaka, K., Shimizu, T., Tanigawara, Y., Yasuhara, M., Hori, R., Kakehi, Y., Yoshida,., Ueda, K., Komano, T., Inui, K.: J. Pharmacol. O Exp. Ther., 275, (1995) 34) Schinkel, A. H., Smit, J. J., Tellingen, O. V., Beijnen, J. H., Wagenaar, E., Deemter, L. V., Mol, C. A., Valk, M. A. V. D., Robanus-Maandag, E. C., Riele, H. P. T., Berns, A. J. M., Borst, P. : Cell, 77, (1994) 35) Gross, S. R., Aronow, L., Pratt, W. B. : Biochem. Biophys. Res. Commun., 32, (1968) 36) Arceci, R. J., Croop, J. M., Horwitz, S. B., Housman, D. : Proc. Natl. Acad. Sci. USA, 85, (1988) 37) Ueda, K., Okamura, N., Hirai, M., Tanigawara, Y., Saeki, T., Kioka, N., Komano, T., Hori, R.: J. Biol. Chem., 267, (1992) 38) Tanigawara, Y., Okamura, N., Hirai, M., Yasuhara, M., Ueda, K., Kioka, N., Komano, T., Hori, R. : J. Pharmacol. Exp. Ther., 263, (1992) 39) Saeki, T., Ueda, K., Tanigawara, Y., Hori, R., Komano, T. : FEBS Lett., 324, (1993) 40) Saeki, T., Ueda, K., Tanigawara, Y., Hori, R., Komano, T. : J. Biol. Chem., 268, (1993) 41) Okamura, N., Hirai, M., Tanigawara, Y., Tanaka, K., Yasuhara, M., Ueda, K., Komano, T.,
10 Hori, R.: J. Pharmacol. Exp. Ther., 266, (1993) 42) Valverde, M. A., Diaz, M., Sepulveda, F. V., Gill, D. R., Hyde, S. C., Higgins, C. F. : Nature, 355, (1992) 43) Hardy, S. P., Goodfellow, H. R., Valverde, M. A., Gill, D. R., Sepulveda, V., Higgins, C. F. : EMBO
Kazumitsu Ueda, E-mail : [email protected] http : //cseika-1, kais.kyoto-u.ac.j p Molecular mechanism of multidrug transporter MDR I : ABC in host-defense machinery 32P-ATP 1) Chen, C., Chin,
1) van Meer, G., Op den Kamp, J. A.: J. Cell. Biochem., 19, 193-2040982) 2) Gaffet, P., Bettache, N., Bienvenue, A.: Biochemistry, 34, 6762-6769(1995) 3) Sims, P. J., Wiedmer, T.: Thromb. Haemost., 86,
Various function and toxicity of iron Key words 1) Hentze, M. W. et al: Cell, 117, 285-297 (2004) 2) Ganz, T.: Blood, 102, 783-788 (2003) 3) Nemeth, E. et al.: Science, 306, 2090-2093 (2004) 4) Hentze,
表1.eps
Vol.1 C ontents 1 2 cell-free EMBO J Proc. Natl. Acad. Sci. USA NatureEMBO J 3 RNA NatureEMBO J Nature EMBO J 4 5 HCV HCV HCV HCV RNA HCV in situ 6 7 8 Nat Struct Mol Biol J Biol Chem Nat Commun J Virol
10中西_他.indd
Streptomyces mobaraensis N N N Sm b Sm N N Sm Sm Sm ' ' Sm Sm ak K k K bk k K Sm Sm a b S. mobaraensis a b a b Sm b b bb b b Sm Sm S. lividans ab Sm ab Sm ab ab ab ab SmSm S. lividansab S. lividans ab
tary adenylate cyclase activating polypeptide ; PA-
Conformation of a peptide ligand bound to its G-protein coupled receptor and its implication for ligand transportation tary adenylate cyclase activating polypeptide ; PA- molecular biology (ed. Rich,
Minamiooya, Machida, Tokyo 194, Japan] RNA World, A Key Step in the Origin of Life : Inspection from the View Point of Biological Evolution 1) Crick, F. H. C.: Sym. Soc. Exp. Biol., 12, 548-555
[Department of Pediatrics, Gifu University School Clinical. Pathological and Biochemical Abnormality in peroxisomal Disorders 1) Goldfischer, S., Moore, C. L., Johnson, A. B., Spiro, A. J., Valsamis,
2007050781......_.L.O...z.W
a s d f g a s d f g h j k l 0 in vitro in vivo in vitro in vivo in vivo in vivo in vitro Metabolism Metabolism Endocr Endocr Endocrinol Ann NYA cad Sci J clin Endocr Metab
Database Center for Life Science Online Service Matthias P. Mayer*, Toshifumi Tomoyasu* *, Bernd Bukau*, Institut fiir Biochemie and Molekularbiologie
Matthias P. Mayer*, Toshifumi Tomoyasu* *, Bernd Bukau*, Institut fiir Biochemie and Molekularbiologie Universitat Freiburg Zentrum fur Molekulare Biologie (ZMBH) Universitat Heidelberg E-mail : [email protected]
437“ƒ
et al., et al., et al., et al., et al., et al., 2 et al., et al., et al., Lancet Pharmacol Res. et al. Jpn J Cancer Res. et al. Jpn J Cancer Res. et al. Tohoku J Exp Med. et al. Jpn Circ J. et al. Cancer
本文/YA9255F
pp. ATP ε ATP ATP ATP ε Bacillus PS ATP ATP H H µ H ATP ATP ADP µ H ATP FoF -ATP FoF -ATP µ H H ADP ATP H Na On the regulatory role of the epsilon subunit in ATP synthase Yasuyuki Kato-Yamada Department
Teru Ogura, Tomoko Yamada-Inagawa, E-mail : [email protected] AAA family ATPases : ring-shaped chaperones which catalyze energy-dependent conformational changes of proteins 29) Braun, S.,
2
1999 No. 5 CHAPERONE NEWSLETTER CONTENTS 2 3 4 JEM JEM JEM, SEC, SCJ JEM JEM SCJ jem, scj 5 in vitro S. cerevisiae 6 K 7 in vitro Cell Mol. Cell in vitro 8 9 E. coli E. coli 10 in vitro ssc - b 11 in vivo
/‚“1/ŒxŒ{‚×›î’æ’¶
60 1 pp.3-8 2010 1. H1N1 1) 2) 3) 4) ERATO 2009 H1N1 21 H1N1 HA PB2 2009 3 Pandemic H1N1 2009 WHO 6 11 21 2009 11 2010 4 21 H1N1 H1N1 2009 4 15 CDC 108-8639 4-6-1 TEL: 03-5449-5281 FAX: 03-5449-5408 E-mail:
Establishment and progress of Sendai virus engineering 2) Schnell, M. J., Mebatsion, T., Conzelmann, K.-K.: EMBO J., 13,4195-4203(1994) 3) Kato, A. et al.: Genes Cells, 1, 569-579 (1996) 4) Nagai,
VOL33NO.3/2010 A B A B p-erk1/2 Time (min) 0 1 2 5 10 15 30 60 90 120 Erk1/2 Time (min) 0 1 2 5 10 15 30 60 90 120 p-vasp VASP C D enos/gapdh x-fold vs sham 2.0 1.5 1.0 0.5 * 0 ANP (-) (+) (-)
4) H. Takayama et al.: J. Med. Chem., 45, 1949 (2002). 5) H. Takayama et al.: J. Am. Chem. Soc., 112, 8635 (2000). 6) H. Takayama et al.: Tetrahedron Lett., 42, 2995 (2001). 9) M. Kitajima et al: Chem.
2007 Vol.56 No.6 総説 丸山浩樹
Reprinted from RADIOISOTOPES, Vol.56,.6 June 2007 Japan Radioisotope Association http : //www.jrias.or.jp/ α β α β ε m z α µ µ α m z m z µ µ Curr. Opin. Biotechnol J. Proteome Res Rapid Commun. Mass
本文/AY380J
MHC-II II MHC-II MHC- II CD T T TCR T T MHC-II MHC-II T MHC-II MHC-II MHC-II MHC-II Ii Ii-MHC-II MHC-II antigen processing compartment MIIC Regulation of cell surface expression of MHC-II in dendritic
.i...j...[.X8-2
Vol. 8 No.2 Nov. 2007 1 2 4 12 20 37 45 54 56 62 1 2 3 4 5 7 6 8 9 10 11 13 12 15 14 17 16 19 18 21 20 Hatena 23 22 Oidiodendron Oidiodendron 25 24 Monosiga ovata Monosiga 27 26 Toxoplasma gondii 29 28
The Heart Healthy Tocotrienol Complex Tocomin SupraBio
The Heart Healthy Tocotrienol Complex Tocomin SupraBio The Heart Healthy Tocotrienol Complex Tocomin SupraBio 1. Fact Sheet No. 317; World Health Organization (WHO), 2007 2. LLOYD-JONES D. et al. Circulation
Review Column 1) Extavour, C. G., Akam, M. : Development, 130, 5869-5884 (2003) 2) Saitou, M. et al.: Philos. Trans. R. Soc. Lond. B. Biol. Sci., 358,1363-1370(2003) 3) Eddy, E. M. : Int. Rev.
Short Review Hidenori Takagi, Fumio Takaiwa, E-mail : [email protected] 13) Hirahara, K. et al. : J. Allergy Clin. Immunol., 102, 961-967 (1998) 14) Takagi, H. et al.: Proc. Natl. Acad. Sci.
3) Z. Nambu: in preparation (1971). 4) N. P. Wilkins & J. D. Iles: Comp. Biochem. Physiol., 17, 1141 (1966). 5) V. M. Ingram: Nature, 235, 338 (1972). Bacillus cereus var. mycoides, Bacillus thuringiensis
(Sinorhizobium melitoti )
ID ID INDE- TERMINATE (ID) /JST CREST E-mail : masayosicbiol. s.u-tokyo.ac.j p Systemic regulatory system sustaining symbiosis and organ development in legume (Sinorhizobium melitoti ) astray sunn nts
Fragaria x ananassa Bioengineering College of Jimei University, Jimei, Xiamen 361021, Fujian Province, China Department of Food Science and Technology, Tokyo University of Marine Science and Technology,
(1) C A. Coulson: Valence, Oxford-Clarendon Press, 1952. (2) L Pauling: The Nature of the Chemical Bond, Cornell Univ Press, 1940, 1960 (3) G. C Pimentel, A L McClellan: The Hydrogen Bond, W. H. Freeman
Database Center for Life Science Online Service
アデノウイルスベクターの改良と応用 7 ン トネ ガ テ ィ ブ を用 い てRel NF-κBの シグナル の不 活 化 を 試 み た そ の 結 果 IκBの ド ミナ ン トネ ガ テ ィ ブ を ニ ワ ト リ胚 肢 芽 に 接 種 した 群 で は 発 現 率 は低 い もの の 四 肢 の 形 成 阻 害 が 認 め られ この 結 果 は頂 堤 AER)を 除 去 した も の の表
E-mail : [email protected] htm Spindle checkpoint : Cell cycle regulation by a signal emitted from kinetochores http://www.rbc.kyoto-u.ac.jp/radiation_system/m-index. 19) Yao, X., Abrieu,
Stress-responsive MAP kinases 15) Lu, H. T., Yang, D. D., Wysk, M., Gatti, E., Mellman, I., Davis, R. J., Flavell, R. A. : EMBO J., 18,1845-1857 (1999) 16) Lu, B., Yu, H., Chow, C., Li, B., Zheng,
Biology of spermatogenesis and spermatozoa in mammals. Biophys. Biochem. Cytol. Arch. Biochem. Biophys. Anat. Rec. Biol. Reprod. Mol. Hum. Reprod. Biol. Reprod. Reprod. Biol. Endocrinol. Aust. J. Zool.
Database Center for Life Science Online Service archlaboratories, 4-1-1 Miyazaki, Miyamae-ku, Kawasaki-shi, Kanagawa 213, Japan] Developmental Genetics of Caenorhabditis elegans Database Center for
Technical Bulletin TransFast TM Transfection Reagent E /
Technical Bulletin TransFast TM Transfection Reagent E2431 http://www.promega.com/tbs/tb260/tb260.pdf / www.promega.co.jp 2006 8 TransFast TM Transfection Reagent E2431 I....................................................................
Database Center for Life Science Online Service
図8SINEの SINEと3'末 親 と な って い るLINEの 系 統 関係 端 を共 有 して い るLINEは 赤 色 で 示 す, 報 告 さ れ て い るす べ て のLINEは11の ら れ る.そ れ ぞ れ のLINEの グル ー プ に分 け あ い だ にお い て 水 平 的 な交 流 が な い と仮 定 す る と,こ の11に 分 け られ る こ のLINE え
日本皮膚科学会雑誌第122巻第2号
J Dermatol Sci Vitam Horm NEnglJMed Lancet J Clin Invest Antitoxid Redox Signal Diabetes Metab Res Rev Diabetes Care Diabet Med Diabetes care Diabetes Care J Foot Ankle Surg Wound Repair Regen Lancet Foot
図1 A:融 試 験 管 内 受 精 と胚 様 体 発 育 お よび 植 物 体 再 生(ト ウ モ ロ コ シ) 合 前 の卵 細 胞(E)と 精 細 胞(S).バ ー=50μm, B:第1回 の 分 裂(融 合42時 間 後).バ ー=50μm, C:多 細 胞体(5日 後).バ ー=100μm, D:分 極 した 多 細 胞 体.一 方 の 極 に 細 胞 層 が,も う一 方 に液 胞 の
