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1 Streptomyces mobaraensis N N N Sm b Sm N N Sm

2 Sm Sm ' ' Sm Sm ak K k K bk k K

3 Sm Sm a b S. mobaraensis a b a b Sm b b bb b b Sm Sm S. lividans ab Sm ab Sm ab ab ab ab SmSm S. lividansab S. lividans ab S. lividansab S. lividans n f Sm Sm

4 Sm a b ba ba E. coli ba Sm Sm S. lividansabs. lividansab S. lividans ab Sm f ab f S. lividans ab S. lividansab Sm Sm S. lividansab

5 Sm Sm S. lividansab Sm Sm Sm a Sm Sm E. coli ba Sm Sm Sm Sm Sm Sm Sm

6

7 n n S. mobaraensis S. mobaraensis S. lividans E. coli S. lividans Sm Sm Streptomyces mobaraensis N NJ. Agric. Food Chem., Biochem. Mol. Biol. Int., Streptomyces mobaraensis. J. Biotechnol., Biochem. Biophys. Acta, Life Sci.,

8 Eur. J. Pharmacol., Br. J. Anaesth., Tetrahedron Lett., Biotechnol. Lett., Streptomyces mobaraensis. Biosci. Biotechnol. Biochem., Eur. J. Biochem., J. Biosci. Bioeng., Streptomyces. Proc. Natl. Acad. Sci. USA, Protein Sci.,

9 Streptomyces mobaraensis Streptomyces mobaraensis N S. mobaraensis Sm b Sm Sm S. lividansescherichia coli.s. lividanssm E. coli

2007050781......_.L.O...z.W

2007050781......_.L.O...z.W a s d f g a s d f g h j k l 0 in vitro in vivo in vitro in vivo in vivo in vivo in vitro Metabolism Metabolism Endocr Endocr Endocrinol Ann NYA cad Sci J clin Endocr Metab

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, 1. x 2 1 = (x 1)(x + 1) x 3 1 = (x 1)(x 2 + x + 1). a 2 b 2 = (a b)(a + b) a 3 b 3 = (a b)(a 2 + ab + b 2 ) 2 2, 2.. x a b b 2. b {( 2 a } b )2 1 =

, 1. x 2 1 = (x 1)(x + 1) x 3 1 = (x 1)(x 2 + x + 1). a 2 b 2 = (a b)(a + b) a 3 b 3 = (a b)(a 2 + ab + b 2 ) 2 2, 2.. x a b b 2. b {( 2 a } b )2 1 = x n 1 1.,,.,. 2..... 4 = 2 2 12 = 2 2 3 6 = 2 3 14 = 2 7 8 = 2 2 2 15 = 3 5 9 = 3 3 16 = 2 2 2 2 10 = 2 5 18 = 2 3 3 2, 3, 5, 7, 11, 13, 17, 19.,, 2,.,.,.,?.,,. 1 , 1. x 2 1 = (x 1)(x + 1) x 3 1 = (x 1)(x

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