3, 3-1 200019 4800 CAS 91941 1138 3, 3-4, 4 - -3, 3 - H 2 N Cl Cl NH 2 C 12 H 10 C l2 N 2 253.13 1 95 1. 2 3, 4 132-133 402 5 >200 5 700kg/m 3 5 8.73 = 1 5.610-8 kpa 4.210-7 mmhg20 4 6 log Pow3.51 3.57 m/z 252, 1.0 254 0.66 253 0.16 7 Koc26.7-128 8 3, 3 - / 3.1 mg/l 4 2
3, 3-2 2. 9 4,104 t 9 1 3. 1 10 4 100 mg/l 30 mg/l BOD 1 32 2 4 40mg 14 C 8, /kg 11 8, 1 11 OH = 210-10 cm 3 / sec 11 OH 510 5 110 6 /cm 3 12 3.6 ppm 3.5 78 = 90 3-8, 3-11 2 4.5 Av. 10 1 50 µg/l 43169 2 5 µg/l 78213 5 Lepomis macrochurus 265-507 Leuciscus idusmelanotus 610 Chlorella fusca var. vacuolata 940
3, 3-3 12 3 ppb ppb ppm B/A B/A B/A B/A 54 0/21 0.017 0/21 0.3900 B/A 4. LC 50 mg/l EC 50 mg/l * 13 : Scenedesmus 2.1 72-h: 2 subspicatus 5 Daphnia magna 14 1.05 48-h: 2 Lepomis macrochirus 5 Pimephales promelas 14 0.5 96-h 1.77 96-h Brachydanio 3.3 96-h rerio 5 * OECD 1 2 2 5. 8, 15 1 LD 50 LC 50 LD 50 7,070 mg/kg 3,820 mg/kg >8,000 mg/kg 100 mg/kg 11 1 8
3, 3-4 2 100 mg 11 700 mg/kg 11 11 3 4 1 9.1-12.8 mg/kg/ 100 mg// 6 3 / 5 / 7.1 ALT 16 2 355 mg 15L 23,700 mg/m 3 2 / 7 11 5 * In vitro In vivo TA98TA1538 S9 +/- 11 DNA TA100TA1535S9 + 11 TA98TA100TA1538 S9 +/- 15 WP2S9-4 S9 +/- 4 S9 + HeLa S9 + 10-7 -10-4 M 11, 15 ICR 1,000 mg/kg 11 15 16 1,000 mg/kg 11 11 10 mg/kg DNA 50 200 500 1,000 mg/kg * 11 500 mg/kg
3, 3-5 6 1 ICR 0.1 6 12 8, 11, 15, 17 Rappolovo 10-20 mg// 6 / 12 4.5 g/ 8, 11, 15, 17 ShR-CD 50 mg/kg/day 0.1 349-353 8, 11, 15, 17 0.1 3, 3-60 40 0.3 8, 11, 15, 17 9.1-12.8 mg/kg/ 100 mg// 6 3 / 5 / 7.1 8, 11, 15, 17 2 6 120 mg/ 5-6 20 mg/ 1 8, 11, 15 3 BALB/c 2 mg// 5 12-20 11, 15, 17 7 1 2 mg/day 19 20 11 6. 1 11 25 mg/m 3 11 22 15 296 µg/l 0.008-2.88 µg/cm 2
3, 3-6 0.54 µg/cm 2 11 11 2 15 18, 19, 20 3 EPA 1999 EU 1998 B2 2 NTP 2000 * IARC 1999 2B ACGIH 2000 A3 1999 2 B 3, 3-11 11 8 180 11 3 11, 15 35 15 207 17 175 11 19, 20 4 ACGIH 2000 1999
3, 3-7 7. 14 C 1 g 24 50 40 mg/ 1.59 8 11 330-500 mg/kg 2 24 11 40 mg 24-96 1 mg/kg 11 1 g 2 0.2 15 40 mg 5 11 30-85 7 10-40 15 3-5 14 15 DNA 11 DNA DNA S9 mix 8-15 11 DNA 824168 8 DNA 8-24 DNA 40 50 7 7 40 DNA 7 11 13 8. OECD * 5 1 * OECD OECD
3, 3-8 9. 1 in vitroin vivo IARC 2B OH 2 1 2 3 in vitroin vivo 4 12 10 14 3
3, 3-9 1 2000. 2, 1994. 3) The Merck Index, 12th. Ed., Merck & Co., Inc. 1996. 4 Sharat Gangolli, The Dictionary of Substances and their Effects, 2nd. Ed., The Royal Society of Chemistry 1999. 5 IUCLID International Uniform Chemical Information Data Base Data Sheet, EU 1995. 6 C Log P,. 7 NIST Library of 54K Compounds. 8 Hazardous Substances Data Bank HSDB, U.S. National Library of Medicine 1998. 9 673 1998. 10,,, 1992. 11 BUA Report, 30 1989. 12, 1999. 13 OECD, Harmonised Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures, OECD Series on Testing and Assessment No. 33 2001. 14 AQUIRE US EPA, ECOTOX Database System. 15 IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, 29 1982. 16 IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, 4 1974. 17 Integrated Risk Information System IRIS, U.S. Environmental Protection Agency 1998. 18 JETOC,,, 4 1999. 19 ACGIH, Booklet of the Threshold Limit Values and Biological Exposure Indices 2000. 20,, 41, 96-158 1999. 1 2 3
mg/l 10 1 2.1 72-h 1.05 48-h 1.77 96-h 3.3 96-h 0.5 96-h LC 50 EC 50 0.1 1 AQUIRE US EPA, ECOTOX Database System. 2 IUCLID International Uniform Chemical Information Data Base Data Sheet, EU 1995.
3, 3-11 : 0.1 6 12 1-4 ICR : 6 12 0.1 0.1 0/5 8/8 2/21 18/18 : 50 mg/kg/day 50 mg/kg/day 1-4 ShR-CD 0.1 : 349-353 2/44 9/44 0/44 7/44 0/44 8/44 Beagle BALB/C 3/44 26/44 : 100 mg// 100 mg// 9.1-12.8 mg/kg/ : 3 / 6, 0/6 4/4 5 / 7.1 0/6 3/4 : 12-20 2 mg// 5 2mg// 6/30 13/24 0/30 7/24 1-4 1, 3, 4 1 IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, 29 1982. 2 Hazardous Substances Data Bank HSDB, U.S. National Library of Medicine 1998. 3 Integrated Risk Information System IRIS, U.S. Environmental Protection Agency 1998. 4 BUA Report, 30 1989.
3, 3-12 6-12 month 349-353 d 1 0.1 0.1 0.3 0.1 0.1 0.01