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1322 quinidine, disopyramide, and procainamide in isolated atrial myocytes : Mediation by 2) Inoue H, et al: Effects of pentisomide and E-4031 on canine atrial flutter due to reentry : A comparative study with disopyramide and propafenone. J Cardiovasc Pharmacol 18: 137, 1991. 3) Inoue H, et al : Antiarrhythmic drugs preferentially produce conduction block at the area of slow conduction in the reentrant circuit of canine atrial flutter : A comparative study of disopyramide, flecainide and E-4031. Cardiovasc Res 25: 223, 1991. 4) Kuo S, et al: Effects of class lc antiarrhythmic drugs on ventricular fibrillation threshold and defibrillation threshold. Š e. 5) Kurachi Y, et al: Quinidine inhibition of the muscarinic receptor-activated K+ channel current in atrial cells of guinea pig. Naunyn- Schmiedberg's Arch Pharmacol 335: 216, 1987. coronary occlusion. Jai) Heart J 12: 368, 1971. 7) Murakawa Y, Sugimoto T : Effect of procainamide on the induction of ventricular fibrillation by sequential ventricular stimulation. Jpn Circ J 51 : 203, 1987. 8) Murakawa Y, et al : Effects of antiarrhythmic drugs on the repetitive extrasystole threshold and the ventricular fibrillation threshold. Cardiology 76: 58, 1989. 9) Murakawa Y, et al: Epicardial mapping of polymorphous ventricular tachycardias induced in the canine heart with procainamide. Amer Heart J 115: 1037, 1988. 10) Murakawa Y, et al : Reappraisal of the coupling interval of premature ventricular beats as an index of ectopic mechanisms.ˆó ü 11) Murakawa Y, et al: A positive correlation between ventricular ectopic beat frequency and heart rate in patients with probable parasytole. 29) Toda I, et al : Ventricular fibrillation thresh- old measured by continuous 50cps stimulation 13) Nozaki A, et al: Attenuation of of the drugs. Jpn Circ J 52 : 249, 1988. antifibrillatory effect of lidocaine by its 30) Toda 1, et al: Effects of a thromboxane A2 synthetase inhibitor on ventricular fibrillation threshold during coronary artery occlusion and 15) Nakajima T, et al : Anti-cholinergic effects of different molecular mechanisms. Circulation Res 64 : 297, 1989. 16) Nakajima T, et al: Auditory stimuli as a cause of syncope : Report of a case with long QT svndrome. Š e 19) Sugimoto T, et al : Factors determining vulnerability to ventricular fibrillation by 60cps alternating currents. Circualtion Res 21 : 601, 1967. 20) Sugimoto T, et a] : Electrophysiologic effects of lidocaine in awake dogs. J Pharmacol Exp Therap 166: 146, 1969. 21) Sugimoto T, et al: Effects of cardiac nerve stimulation on ventricular arrhythmias after 27) Sugimoto T, et al : Effects of antiarrhythmic drugs on the ventricular fibrillation threshold determined by the continuous 50 cps stimulation method. Current Topics in Antiarrhythmic Agents edited by Toyama Y, et al, Excerpta Medica, Tokyo, 1989. p148 28) Sugimoto T, et al : Evaluation of antifibrillatory 64: 331, 1989. effects of drugs. Amer J Cardiol for the evaluation of the antifibrillatory effect reperfusion. Jpn Heart J 31 : 87, 1990. (22)

1323 effects of acute volume load on electro- physiological properties in isolated rabbit 32) Ueda H, et al: Changes in cardiac rate and rhythm produced by electrical stimulation of the brain stem of dogs. Jpn Heart J 3 : 455,1962. 33) Ueda H, et al: Arrhythmias produced by 38) Yamashita T, et al: Role of anisotropy in cardiac nervous stimulation. Jpn Heart J 4: 356, 1961 26: 244, 1992 39) Yamashita T, et al : Role of anatomical ar chitechture in sustained atrial reentry and 36) Yamashita T, et al: Time-dependency of determining the selective action of antiarrhyth mics in atrial flutter in the dog. Cardiovasc Re: (23)