平成１３年度内分泌攪乱化学物質のヒトへの健康影響調査研究報告書

. 1,3 4 5. 1 2 NB-1 MCF7 MEIC 1-3 4-6 NB-1 JCRB Japan Cancer Research Bank MCF ATCCAmerican Type Culture Collection

2 19994 212 11 PVDF.22µm 8 2 11 4 4 3 5 1 4 cellsml -1 96 4,6 NB-1 48 MCF7 24 4 5 48 7 NB-15.6 MCF7 3. 4 ph T-COD D-COD T-N DTN T-P DTP SS a 28 12 7 7 2 6 IBP, Flutolanil, Pyroquilon, Isoprothiolane, Simetryn, Bromobutide 5 28 St.1 3 ODS (MCF7

1 4 3 St.2 St.7 St.9 1999 2 5 8 2 5 8 8 LRRRYR 24 milliosmolel -1, ph 7.68.2 2 6 NOEC NOEC 1 3 4 ODS

3 1999 2 ph LR RRYR 5 8 11 6 NOEC.5-8.71 4 µgl -1.1 -.7 µg L -1 1 ODS 3

1) Clemedson, C., Kunimoto, M. et al. (1996) MEIC evaluation of acute systemic toxicity for the first 3 reference chemicals: Part I. Methodology of the 68 in vitro toxicity assays, ATLA, 24, 251-271. 2) Clemedson, C., Kunimoto, M. et al. (1996) MEIC evaluation of acute systemic toxicity for the first 3 reference chemicals: Part II. In vitro results from 68 methods and comparative cytotoxicity analysis, ATLA, 24, 273-311. 3) Ekwall, B., Kunimoto, M. et al. (1998) MEIC evaluation of acute systemic toxicity: Part. The prediction of human toxicity by rodent LD values and results from 61 in vitro methods, ATLA, 26, 617-658. 4) (21) 24, 11-114. 5) 21 24, 58-63. 6) (1997) 2, 752-756. 7) (1991). 8) (21)

CO 4 CO

NB-1 MCF7 NB-1 MCF7 St.2 St.2 Relative CellSurvival (%) 4 5 6 7 8 9 1 11 12 St.7 4 5 6 7 8 9 1 11 12 St.9 Relative CellSurvival (%) 1 2 3 4 5 6 7 8 9 1 1112 St.7 1 2 3 4 5 6 7 8 9 1 1112 St.9 4 5 6 7 8 9 1 11 12 Month in 1999 1 2 3 4 5 6 7 8 9 1 1112 Month in 2

Concentration (µgl -1 ) 1 1 12 1 8 6 4 2 Phycocyanin B B B B B B B B B HJ H H H B B J J B J J J H H H H H H J J H H J J J J 1 2 3 4 5 6 7 8 9 11112 COD B B B B H B B B B B J J J J JB H H H J J J J J H HHH HHB B H HJ J 2 2 1 2 2 1 T-N B B J B J B B B B B J J B H B B J J J J J J H H H H H B H J J H H H H H 1 2 3 4 5 6 7 8 9 11112 T-P B B B B B B B H B H B J J J B B J J H J J J H H J B H J J H H J H H H H B J H St.2 St.7 St.9 1 2 3 4 5 6 7 8 9 11112 1 2 3 4 5 6 7 8 9 11112 Month in 2 Concentration (µgl -1 ) 1.8.6.4.2 St.2 H F F B É H F ÑF É B J Ñ B J J H H ÉÑ ÉÑ J 7 8 9 St.7 1.8.6.4.2 B É Ñ F F F B J ÉÑ B F HB HJ ÉÑ HJ ÉÑ HJB 6 7 8 9 Month in 2 B IBP F Isoprothiolane J Flutolanil Ñ Simetryn H Pyroquilon É Bromobutide

Relative Cell Survival (%) U.W. U.F. ODS A.C. C.E. A.E.

99/4 NB-1 MCF7 Relative Cell Survival (4% ) 1 2 3 4 6 7 8 9 11 12 99/5 1 2 3 4 6 7 8 9 11 12 99/6 1 2 3 4 6 7 8 9 11 12 Sampling Point (St.NO., K=Kogan)

99/7 NB-1 MCF7 Relative Cell Survival (4% ) 1 2 3 4 6 7 8 9 11 12 99/8 1 2 3 4 6 7 8 9 11 12 99/9 1 2 3 4 6 7 8 9 11 12 Sampling Point (St.NO., K=Kogan)

99/1 NB-1 MCF7 Relative Cell Survival (4% ) 1 2 3 4 6 7 8 9 11 12 99/11 1 2 3 4 6 7 8 9 11 12 99/12 1 2 3 4 6 7 8 9 11 12 Sampling Point (St.NO., K=Kogan)

/1 NB-1 MCF7 Relative Cell Survival (4% ) 1 2 3 4 6 7 8 9 11 12 K /2 1 2 3 4 6 7 8 9 11 12 K /3 1 2 3 4 6 7 8 9 11 12 K Sampling Point (St.NO., K=Kogan)

/4 NB-1 MCF7 Relative Cell Survival (4% ) 1 2 3 4 6 7 8 9 11 12 K /5 1 2 3 4 6 7 8 9 11 12 K /6 1 2 3 4 6 7 8 9 11 12 K Sampling Point (St.NO., K=Kogan)

/7 NB-1 MCF7 Relative Cell Survival (4% ) 1 2 3 4 6 7 8 9 11 12 K /8 1 2 3 4 6 7 8 9 11 12 K /9 1 2 3 4 6 7 8 9 11 12 K Sampling Point (St.NO., K=Kogan)

/1 NB-1 MCF7 Relative Cell Survival (4% ) 1 2 3 4 6 7 8 9 11 12 K /11 1 2 3 4 6 7 8 9 11 12 K /12 1 2 3 4 6 7 8 9 11 12 K Sampling Point (St.NO., K=Kogan)

St.1 NB-1 MCF7 St.2 NB-1 MCF7 St.3 NB-1 MCF7 25. 2.2. 1.7 25.. 7.7. 2.7 25.. 8.9..5 11.9 2.5.2 2...8 2.2.1.3. 14.1 6.7. 2.9 98.6 1.7 11.5.9. 99.6 4.7 11.1 1.9..7 4.8 12. 2.1 2 98.9 3.8 98.4.6 2. 97.3 5.5 11.4 1.1 2..9 4.6 99.8 1.8 3 97.8 3.1 95.1.8 3. 94.5 4. 95.5 1.6 3..8 3.9 93.4 2.4 4 11.2 2.6 95..6 4. 95.2 2. 94.3 2.9 4. 91.2 6.4 95.3 2.5 St.4 NB-1 MCF7 St.6 NB-1 MCF7 St.7 NB-1 MCF7 25. 1.4..4 25.. 4.1. 1.9 25.. 1.7..9 98.1 4.2 12.1 2.3. 15.6 5.6 12.4 1.5. 17..8 99. 1. 92.5 3.8 11.4 1.1. 96.1.3 12.1 2.2. 11.4 4.6 98.1.5 2 9.9 1.9 98.7 1.9 2. 12. 6.2 99.7.9 2..7 3.9 98.2 3.2 3 89.5 4.5 94.1 1.4 3. 98.4 2.7 96.7 3.3 3. 12.1 5.7 92.6 3.3 4 82. 3.2 92. 2.6 4. 98.5 2.3 98.1 2.7 4. 94.2 1.1 91.4 1.5 St.8 NB-1 MCF7 St.9 NB-1 MCF7 St.11 NB-1 MCF7 25. 6.. 2.7 25.. 2.2. 1. 25.. 1.8..6 14.5.9. 3.. 98.6 1.9.7 1.1. 96.5 2.1 11.3 1.9.5 4.9 99..8. 93.8 3.5.9 1.3. 11. 3.1.6.7 2 99.5 2.7 97. 1.7 2. 88.8 4. 98.1 2.5 2. 96.2 3.6 98.5 3.7 3 93.7 6.7 93.3 2.7 3. 88.5 3.5 94.1 1.6 3. 9. 4.1 93. 4.6 4 86.1 4.4 93. 1.5 4. 85.2 5.3 89.8 2.5 4. 86.5 4.5 91.8 2.5 St.12 NB-1 MCF7 K NB-1 MCF7 M.Q. NB-1 MCF7 25. 4.7. 3.1 25.. 3.1 N.D. N.D. 25.. 3.5. 1.6 98.8 4.1 99.9 2.6. 16.4 6.9 N.D. N.D.. 98.2 5.5 99.6.8 98.4 3.6.8 4.1. 12.4 4. N.D. N.D...9 1.8 13. 2.4 2 99. 3.2 99. 3. 2. 99.1 2.2 N.D. N.D. 2. 98.2 1.8 11.4.9 3 9.9 3.5 92.6 2.6 3. 94.6 7.9 N.D. N.D. 3. 95.9 1.2 98.1 5. 4 86.2 2.9 93.6 2.3 4. 98.9 3.9 N.D. N.D. 4. 92. 5.5 96.2 1.3

St.1 NB-1 MCF7 St.2 NB-1 MCF7 St.3 NB-1 MCF7 25. 5.944. 6.4 25..4. 2.7 25. 4.5. 1.1 11.3 1.717.8 3.7 99.5 6. 98. 2.6 96.4 5.5 97.2 2. 98.9 3.329 12.7 2.3.3 3.5 98.7 2.4 97.2 2.5 12.8 3.9 2 95.3 3.524 96.4 3.6 2 97.1 4.9 95.8 2.7 2 95.7.9 94. 2.9 3 99. 4.384 91.2 2. 3 97.4 4.2 91.7 6.5 3 94.1 1.9 87.1 3.1 4 11.6 3.687 89.7 4.8 4 99.2 3.6 87.9 2.4 4 92.3 7.9 85.7 1. St.4 NB-1 MCF7 St.6 NB-1 MCF7 St.7 NB-1 MCF7 25. 1.5. 2.8 25. 4.9. 5. 25. 3.1..7 11.1 5.2 99. 3.5.4 4.4 98.9 4.1 13.3 4.3.9 5.4 96.2 2.8 97.6 3.5 11.6 3.5 15.7 3.5 97.3 3.4 98.6 6.2 2 97.7 2.6 94.8 3.8 2 97.6 2.8. 3. 2 97.3 4.7 94.2 5.4 3 96.5 4.3 91. 1.4 3 92.4 4.7 97.7 3.8 3 97.1 3.2 86.1 3.2 4 92.6 7.4 87.1 3.8 4 95. 3.2 97.5 5.3 4 97.1 2.3 87.6 4.5 St.8 NB-1 MCF7 St.9 NB-1 MCF7 St.11 NB-1 MCF7 25. 3.373. 7.1 25..3. 5. 25. 1.5. 1. 98.5 3.691 99.4 2.4 92.1 2.2 95.8 3.7 99.3 2. 99.6 1.2 98.4 5. 11.7 2. 93.5 2.4 95.7 3.1 98.1 2.4 99.6 2.3 2 95.2 1.15 96.4 2.5 2 86.4 1.4 91.9 3.4 2 95.6.8 95. 8. 3 91.5 5.58 89.4 4.8 3 86.3 4.3 9.4 4.7 3 93.6 2.9 96.6 2.3 4 93. 4.333 83. 1. 4 75.4 5.3 83.6 3.4 4 89.3 7.4 94.4 6.1 St.12 NB-1 MCF7 K NB-1 MCF7 M.Q. NB-1 MCF7 25. 9.431. 6.1 25. 2.5. 1.9 25. 3.5. 3.4 98.2 8.236 95.4 6. 99.8 4.4.7 3.3 98.2 5.5 98.8 2.4 94.3 4. 99.4 6.7.8 1.8 12.2 3.2.9 1.8 13. 4.5 2 92.1 2.76 94.5 8.7 2 95.1 1.4 14.1 2.7 2 98.2 1.8 99.9 4.4 3 89.1 2.36 93.1 4. 3 91.8 3.9 95.1 3.6 3 95.9 1.2.2 1.8 4 85.3 5.916 89.9 4.5 4 86.9 5. 95.9 2.8 4 92. 5.5 11.1 4.5

St.1 NB-1 MCF7 St.2 NB-1 MCF7 St.3 NB-1 MCF7 25. 4.9. 2.9 25. 4.5. 3. 25. 7.5. 3.2 16.1 2.5 12.7 1.4 12.3 2. 98.3 4.9. 3.2 11.3 3.4 11.1 3.2 99.3 4.7 11.4 3..4 1.9 11.3 6.3 12.3 5.5 2 13.1 3.1 94.5 4.7 2 98.9 2. 95.2 3.5 2 98.5 4.4. 4.6 3 98.3 4.5 9.5 3. 3 96.8 3. 97.5 3.9 3 95. 6.3 92.8 3.9 4 96.5.4 93.7 2.8 4 86.1 4.4 94.5 4.2 4 83.6 6. 87. 4. St.4 NB-1 MCF7 St.6 NB-1 MCF7 St.7 NB-1 MCF7 25. 1.5. 1.7 25. 3.9. 4.3 25. 1.9. 4.9.7 4.8 13.9 8. 12.3 1.8 96.7 4.1.3 4. 11.5 5.2 12.8 4.9. 3.1 16.4 1.2 99.5 3.7 13.8 3.9 13.2 1.4 2 92..8 96.4 3.5 2.5 3.7 11.2 3.8 2 97.5 2.8 12.8 1.7 3 93. 3. 11.5 2.1 3.2 5.1 96.4 1.6 3 95.3 4.6 97.3 7.4 4 81.7 4.7 9.9 4.1 4 91.9 2.8 94.8 4.4 4 86.2 4.1 93.6 4.8 St.8 NB-1 MCF7 St.9 NB-1 MCF7 St.11 NB-1 MCF7 25. 2.2. 3.7 25. 6.. 1.7 25. 3.. 3.3 96.8 1.5 17.7 5.3 99. 5. 12.5 3.6 96.3 5.5.9 2.9 94.7 2.3 99.9 4.7 97.7 3.5 12.6 6.4 98.6 5.3.1 4. 2 9. 3.4 12.7 4.4 2 91.1 1.2 94.4 5.1 2 97.3 5.7 89.9 2.3 3 89..3 96.1 3.2 3 9.8 2.8 92. 5.8 3 93.9 4.6 89.4 4.2 4 92. 1.9 92.2 4.2 4 91.9 5.9 85.5 4. 4 94.4 4.1 91.3 6. St.12 NB-1 MCF7 K NB-1 MCF7 M.Q. NB-1 MCF7 25. 3.9. 3.1 25. 2.4. 2.4 25. 3.5. 3.4 98.3 3.7 13.7 5.8 12.7 3.8 95.8 4.3 98.2 5.5 98.8 2.4.4 5. 16.7 8.3 95.4 2.2 11.2 1.2.9 1.8 13. 4.5 2 95.1 2.9 97.2 7.3 2 13.7 4.9 93.6 3.8 2 98.2 1.8 99.9 4.4 3 93.3 3.2 99.6 4.9 3 11.1 2.4 91.8 3.8 3 95.9 1.2.2 1.8 4 91.7 5.3 93.1 4.5 4 94.2 3.3 89.1 4.5 4 92. 5.5 11.1 4.5

St.1 NB-1 MCF7 St.2 NB-1 MCF7 St.3 NB-1 MCF7 25. 4.7. 7.4 25. 5.1. 2.9 25. 9.7. 4.7 15.9 3.2 12.6 4.9 99. 4.5 14.1 4.6 99.5 3.9 13.2 4.9 17.1 3.8 11. 1.4 95.2 2.2 15. 4.2 98.2 3.2.7 2.6 2 13. 3.7 11.1 1.4 2.5 8.6 12.4 4.6 2.5 4.4 99.6 5.2 3.5 6.9 95.9 3.6 3 93.3 4. 12.4 6.4 3 96. 3.9 96.8 3.6 4 16.4 2.5 99.2 4.8 4 95.3 5.7 98.1 4.7 4 9.5 2.1 95.2 3.7 St.4 NB-1 MCF7 St.6 NB-1 MCF7 St.7 NB-1 MCF7 25. 3.2. 3.4 25. 9.3. 1.6 25. 3.1. 1.2 14.7 5. 95.1 3.5 94.2 5.5 12.9 4.4 14.1 6.9 95.7 5.8 13.2 1.2 96.4 3.6 97.3 3.6 14.3 3.5 13.1 5.7 96.7 2.1 2 19.7 1. 95.4 3.7 2 93.2 4.8 97.8 4.7 2 13.8 1.9 97.5 5.2 3 11. 4.6 92. 3. 3 96.3 7.6 89.2 7.3 3 96.8 2.3 88.3 6.9 4 96. 7.8 91.5 2.4 4 97.5 3.4 94.4 5.3 4 15.6 5.8 9.4 3.5 St.8 NB-1 MCF7 St.9 NB-1 MCF7 St.11 NB-1 MCF7 25. 3.. 4.4 25. 7.1. 2.2 25. 2.3. 3.4 11.9 1.4 95.9 5. 98.9 2.5 98.1 5.4.5 6.9 98.6 2.2.9 2. 96.1 9.5 98.4 1.3 97.2 2.9 98.1 3.9 13. 2.2 2 12.1 4.7 94.4 6.7 2 95.1 7.3 95.1 3.3 2 12.4 3.1 96.9 2.4 3 95.6 3.1 84.8 9.9 3 87.3 4.3 89.2 8.4 3 94.6 2.7 91.5 3.7 4 98.2 3.4 84.3 8.1 4 93.2 7.9 86. 6. 4 93.7 3.2 89.4 1.4 St.12 NB-1 MCF7 K NB-1 MCF7 M.Q. NB-1 MCF7 25. 5.9. 3.2 25. 11.. 2.3 25. 1.4. 5..4 4.1 99.6 4.2 93. 3.2 98. 1.8 15.7 1.2.3 2.4 96.9 2.3 11.8 2.2 96.5 3.8 94.3 2.8 13.6 4.4 12.8 4.2 2 96.5 4.3 11.1 3.6 2 92.8 4.1 94.3 3.1 2 99.8 3.5 15.5 3. 3 92.5 7.1 89.7 3.8 3 9.7 4.7 88.3 6.3 3 14.2 5.5 99.2 1.6 4 98.9 2.7 92.6 2.1 4 93.2 4.1 85.2 1.1 4 92.4 7.5 96. 5.

St.1 NB-1 MCF7 St.2 NB-1 MCF7 St.3 NB-1 MCF7 25. 3.5. 4.2 25. 2.1. 6.6 25. 2.4. 3.8 98. 3.1.6 1.1.1 3.4.7 2.3 12.9 3.5 11.5 1.3 93.5 3.1 11.3 3. 99.7 6.3.6 1.9 96.3 4.9 14.7 6.3 2 94.4 1.8 92.2 3.6 2 94.3 4.2 93.8 6.6 2 95.2 5.1 93.1 2.3 3 84.4 3.3 85.4 2.7 3 87.2 5.5 86. 5. 3 85.4 4.5 87.4 7. 4 84.6 3.9 79.1 5.1 4 81.3 3.6 8.6 3.5 4 75.9 5.4 78.5.9 St.4 NB-1 MCF7 St.6 NB-1 MCF7 St.7 NB-1 MCF7 25. 3.2..9 25..9. 5. 25. 3.9. 2.4 12.5 1.8 16.3 5.5.6 2.6.5 4.2 99.3 1. 95.7 1.4 98.5 2.2 17.2 3.1.9 3.. 2. 97.5 8. 91.7 5.7 2 94.9 4.5 14.1 2.8 2 97.9 4. 99.2 2.7 2 12.2 4.1 91.9 3.7 3 92.1 1.7 99.2 5. 3 93.2 6.6 96.4 2.7 3 9.2 3.1 92.1 1.4 4 85.2 5.5 94.5 4.1 4 91.5 3.1 94.5 4.8 4 89.3 4. 9.4 5.6 St.8 NB-1 MCF7 St.9 NB-1 MCF7 St.11 NB-1 MCF7 25. 2.2. 2.8 25. 4.1..6 25. 3.4. 3.5 15.8 2.5 13.2 2.4 96.8 2.2 13.3 3.6 14.3 3.9 98.2 9.3 15.2 5.2 98.1 3.6. 3.7 11.3 4.6 13. 4.2 94.2 3.4 2 12.7 2.8 95. 4.8 2 95.4 5.1 96.3 1.9 2 13.3 5. 9.7 4. 3 96.2 6.4 98.1 2. 3 9.3 2.8 95.5 6.5 3 91.8 4.6 86.2 6.6 4 95.6 2.5 93.5 4.4 4 9.1 2.8 92.7 1.8 4 95.6 5.9 88.7 7.1 St.12 NB-1 MCF7 K NB-1 MCF7 M.Q. NB-1 MCF7 25. 2.5. 2. 25. 2.5. 1.7 25. 1.4. 5. 15.7 4. 97.9 6.9 12. 6. 97.5 3.6 15.7 1.2.3 2.4 11.5 4.2 95.8 3.6 13.3 1.4 96.7 5.6 13.6 4.4 12.8 4.2 2 99.7 4.3 92.9 2. 2 99.1 5.3 91.7 2.6 2 99.8 3.5 15.5 3. 3 98.9 1.6 88.4 11.2 3 96.1 3.6 84.7 4.4 3 14.2 5.5 99.2 1.6 4.1 6.8 88.4 3.9 4 94.7 5.3 89.6 6.5 4 92.4 7.5 96. 5.

St.1 NB-1 MCF7 St.2 NB-1 MCF7 St.3 NB-1 MCF7 25. 3.3. 5. 25. 4.. 3. 25. 5.. 5. 93.5 5.9 95.1 4. 11. 2.7 99. 2.5 97. 4.4 99.5 5.6 92.2 5.9 97.4 5.7 93.2 4.4 97.3 2.8 86.3 2.1 11.1 3. 2 75. 7.8 86.3 7. 2 76.5 4.3 87.7 6.4 2 75.4 1. 91.2 2.4 3 65.8 4.8 67.9 4.3 3 62.8.6 72.9 6.3 3 64.1 3.2 77.1 8.1 4 55.7 5.9 63.3 4.7 4 57. 3.6 62.2 3.6 4 55.7 3.5 71.6 5. St.4 NB-1 MCF7 St.6 NB-1 MCF7 St.7 NB-1 MCF7 25. 1.5. 3.8 25. 3.1. 4.1 25. 3.1. 3.4 99.9 5.5 98. 6.1 12.2 4.1 98.3 5.6 15.4 2.4 16. 3. 95.1 1.1 12.5 6.7 99.6 1. 99.3 6.3 97.5 3. 14.1 1.3 2 87.5 4. 98.7 6.1 2 88.8 3.7 96.5 4.1 2 85. 2.9 98. 6.1 3 77.1 4. 87.1 4.4 3 8.8 4.3 87.5 5.5 3 72.3 6.1 84.2 5.8 4 7.5 9. 81.1 4.6 4 71.8 4.2 84.1 5. 4 69.5 5.4 76.5 4.5 St.8 NB-1 MCF7 St.9 NB-1 MCF7 St.11 NB-1 MCF7 25. 5.5. 4.8 25..7..6 25. 3.. 6.7 96.3 5.2 97.6 3.6 97.7 1.3 96.2 3.5 95.8 5.6.9 6.4 94.5 4.7 99.4 5.7 97.2 2.2 99.1 2.6 99. 2.9 98.2 6.3 2 79.5 3.1 93.6 4.3 2 82.7 4. 93.3 3. 2 91.3 2.4 89.8 6.9 3 66.4 2.7 75.1 3.3 3 75.4 4.1 81.5 4.9 3 8.2 1.7 8.3 1.2 4 61.1 3.7 65.3 2.8 4 68. 1.8 79.9 3.4 4 72.1 2.9 74.9 6.1 St.12 NB-1 MCF7 K NB-1 MCF7 M.Q. NB-1 MCF7 25. 3.8. 3.3 25. 4.8..7 25. 3.9. 3.2 12.2 1.8 99.8 7.8 12. 4.5 95.6 4.5 97.3 4.2 98.6 2.8 97.9 1.7 99.8 4.8 95.1 4.4.8 3. 92.6 2.1 12. 3.2 2 91.3 3.5 9.5 5.9 2 9.7 2.3 89.4 3.7 2 99.6 7.8 99.6 5.4 3 86.2 2.4 8.2 7. 3 81.9 4. 79.6 5.9 3 97. 4.4. 3.5 4 74.6 3.6 79.1 6.1 4 74.9 5.9 78.6 4.1 4 86.6 2.7 97.7 6.4

St.1 NB-1 MCF7 St.2 NB-1 MCF7 St.3 NB-1 MCF7 25. 7.9. 4.3 25. 3.6. 3.2 25. 5.1. 5.3 96.8 2.6 13.3 5.4 11.7 3.4 12. 2.7 97.6 3.9.7 3.3 99.1 4.1 99.8 8.4 94.5 3.7 97.4 3.1 97.9 4.8 99. 7.9 2 92.9 5.1 99.4 4.1 2 89.2 4.8 92. 5.8 2 91.7 4.7 98.8 6.8 3 9.4 3.1 99.5 3.5 3 81.7 5.9 9.1 5.8 3 82.4 4.6 96.3 1.7 4 85.7 6.5 96.7 3.3 4 74.5 2.3 82.9 3.6 4 73.9 3.3 88.3 1.5 St.4 NB-1 MCF7 St.6 NB-1 MCF7 St.7 NB-1 MCF7 25. 3.5. 3.3 25. 1.9. 5.2 25. 3.5. 2. 14.7 2.8 97. 6.4 96.9 5. 14. 2.3.6 3.7 13.8 3.4 98.5 3.3 97.1 2.5 97.3 4.3 11.3 1.7 95.5 5.4 14.4 7.7 2 84.5 3.2 92.9 3.4 2 86.4 3.7 98.8.6 2 85.8 5.2 96. 3.5 3 79.4 4.3 82.3 1.6 3 85.3 4.8 86.5 2.6 3 78. 5.3 85.9 3.7 4 67.5 4.2 74.4 3.9 4 73.8 5. 83.9 1.7 4 66.3 4.8 72.9 4.1 St.8 NB-1 MCF7 St.9 NB-1 MCF7 St.11 NB-1 MCF7 25. 4.5. 4.3 25. 6.6. 7.9 25. 5.4. 3.3 94.3 3.1 95.6 2.5.6 5.6 99.6 3.2 99.8 3.5 99.3 2.6 94.6 3.9 98.5 3.7 95.2 2.2 11.8 2.4. 3.4.8 3.7 2 87.4.9 97.5 2.7 2 86.9 4.5 93.7 2.2 2 89.6 2.8 97. 4.8 3 73.2 2.5 85.8 2.5 3 72. 6.5 78.2 4.4 3 8.6 5.3 88.5 5.5 4 61.7 3.4 78.5 5.5 4 65.3 5.1 73.1 2.9 4 68.1 3.3 81.2 3.1 St.12 NB-1 MCF7 K NB-1 MCF7 M.Q. NB-1 MCF7 25. 7.3. 9.2 25. 3.7. 5.6 25. 3.9. 3.4. 7.3 15.4 8.7 96.2 2.7.6 7.4 97.3 4.2 98.8 2.4 97.5 3.4 16.4 4.9 95.5 5.1. 4. 92.6 2.1 13. 4.5 2 91.2 4.1 11.6 5.3 2 88.4 5.2 93.2 5. 2 99.6 7.8 99.9 4.4 3 83.2 3.4 99.9 5. 3 81.4 5.1 87.6 1.9 3 97. 4.4.2 1.8 4 79.1 3.5 92.1 3.2 4 65.8 4.6 79.8 5.4 4 86.6 2.7 11.1 4.5

St.1 NB-1 MCF7 St.2 NB-1 MCF7 St.3 NB-1 MCF7 25. 5.5. 4.3 25. 3.9. 3.7 25. 4.2. 2.2 93.2 5.2 83. 4.8 94.9 6.2 9.5 7.8 94.6 6.6 96.6 5. 81. 4.9 75.9 5.7 8.7 3.2 84.5 6.2 91.8 2.5 91.9 3.4 2 62.2 1.1 55.8 4.5 2 7. 3. 69.6 6.2 2 84.4 6.3 88.6 5.2 3 51.4 4. 45.8 4.4 3 55.9 3.3 58.7 3.4 3 8.4 4.3 71.6 4.7 4 43.9 3.7 45.2 3.5 4 48.4 2.1 57.7 4.3 4 63.9 4.8 71.2 3.8 St.4 NB-1 MCF7 St.6 NB-1 MCF7 St.7 NB-1 MCF7 25..4. 5.8 25. 1.7. 1.7 25. 7.2. 5. 97.9 3.9 91.8 3.2 98.2 4.3 98.8 5.3 13. 7.8 12.4 4. 95.1 4.8 89.9 6.3 97.7 3.9 14.7 4.7 96.5 7.1 99.9 5.3 2 86.8 4. 81.3 5.4 2 94.2 4.1 13. 5.3 2 92.1 3.2 99.4 7.6 3 82.1 6.1 74.3 3.7 3 92.1 2.6 94.9 4.7 3 91.3 3.1 96. 6. 4 64.2 5.8 66.4 6.9 4 93.3.3 13. 6.2 4 83.5 4.7 99.3 4. St.8 NB-1 MCF7 St.9 NB-1 MCF7 St.11 NB-1 MCF7 25. 2.2. 3.6 25. 7.7. 5.3 25. 9.3. 1.1 98.4 4.6 95.1.8.5 3.8 97.1 8.9 12. 5.1 13.2 7.6.7 3. 18.2 7.5 93. 4.6 9.2 5.9 13.7 4. 99. 9.3 2 93.8 4.1 13.8 1. 2 86.9.7 82.8 4.8 2 85.8 2.2 88.7 6. 3 94.3 7.5 99.7 1.8 3 8. 4.8 76.2 5.9 3 79.5 3.3 87.2 4. 4 86.2 4.1 94. 3.6 4 63.4 1.9 7. 5.5 4 7.6 8. 79.4 4.6 St.12 NB-1 MCF7 K NB-1 MCF7 M.Q. NB-1 MCF7 25. 3.3. 3. 25. 1.8. 4.8 25. 1.8. 3.6 99.8 4.1 95. 4.5 97.8 2.8.7 2.9 17.1 4.2.4 1.2 96.3 5.6 92.9 4.1 98.7 6. 13. 3.9 14.7 2.8 95.7 6.5 2 9.6 4.2 86.2 9.1 2 96.8 3.3 14.9 4.9 2 97.4 2.5 92.9 5.6 3 86. 4.8 86.4 2.5 3 94.7 3.4 98.6 3.9 3 11.3 4.9 97.2 5. 4 75.7 7. 8.5 6. 4 81.6 9.8 12.3 3.1 4 89.2 7.2 91.9 2.6

St.1 NB-1 MCF7 St.2 NB-1 MCF7 St.3 NB-1 MCF7 25. 5.. 1.9 25. 2.5. 3.4 25. 3.4..8 98.1 5.5 95. 1.5 98.7 4. 99.8 2. 93. 4.7 95.6 1.2 94.3 4.7 95.9 2.8 85.9 5.7 91.4 1. 84.2 3.2 87.4 1. 2 91.7 3.4 9.6 2.5 2 72.4 5.1 75.3 2.5 2 66.6 5.6 71.7 3.5 3 79.8 3. 82.4 2.9 3 53.4 3.9 63.9 1.8 3 51.3 7. 6.5 1. 4 71.7 3.5 77.5 1. 4 51.3 8.2 56.3 1.2 4 37.7 4.4 54.5 1.1 St.4 NB-1 MCF7 St.6 NB-1 MCF7 St.7 NB-1 MCF7 25. 3.4. 1. 25. 2.6. 2.2 25. 3.. 3.4 98.7 3.7 11. 3.2 98.2 5. 11.1 1.5 93.1 3.3 12.6 2.2 91.3 3.6 98.8 4.4 95.7 5.6 11.9 1.4 91.9 5.6.4 3.3 2 81.6 3.7 87.5 2.1 2 98.7 4.5 98. 1.9 2 91.2 4.7 97.5 1.9 3 7.1 3.3 76.1 1.2 3 91.5 4.6 94..2 3 87.2 2.7 92.7 3.2 4 55.65 2.863 7.28 1.513 4 82.9 7.4 91.3 4. 4 85.2 4.1 87.3 1.4 St.8 NB-1 MCF7 St.9 NB-1 MCF7 St.11 NB-1 MCF7 25. 6.. 1. 25. 2.4.. 25. 5.2. 1.6 96.7.8.7.9 95.8 1.6.6 2..1.5 97.9 2.4 93. 7.4 99.8 2.8 9.9 3.3 97.5 1.5 93.9 2.6 98.5 1.8 2 94.6 2. 98.1 1.9 2 85.4 5.1 94.2 1.6 2 89.7 3.4 89.8 1.1 3 91.7 1. 88.3 1.6 3 79.2 6. 84.6 1.8 3 78.4 2. 79.8 3.1 4 81.8 1. 87.4 1.3 4 67.3 7.7 79..7 4 67. 2.9 73.3 1.3 St.12 NB-1 MCF7 K NB-1 MCF7 M.Q. NB-1 MCF7 25. 4.9. 2. 25. 5.2. 3.8 25. 6.1. 3.8.5 1. 11.9 3.1 11.2 5.1 12.6 1.6 99.4 4.2.2.8 98.8 3.8 11.4 3.2 97.2 2.5 12.7 1.9 99.7 4.8 12.4 1. 2 92.1 1.9 96.9 3.2 2 95.9 4.8 97. 3.4 2.1 4.8 99.5 2.2 3 91.4 4.8 89.1 2.2 3 94.6 3.6 9.3 1.3 3 99. 5.3.6 2.1 4 76.5 7.8 85.1 1.5 4 82.6 4.4 88.2 1.2 4 84.1 2.3 99.4 1.3

St.1 NB-1 MCF7 St.2 NB-1 MCF7 St.3 NB-1 MCF7 25. 6.5. 1.2 25..8. 1.7 25. 6.8. 2.6 95.4 6. 11.6 1.3 98. 4. 99. 1.7 95.5 5.8.1 1.8 98.1 7.3 13. 1.3 91.9 6.9.8 1.2 86.8 6.9.2 2.1 2 95.5 3.2.1 1.4 2 86.8 9.5 91.4 2.9 2 74.9 3.2 88.3 1.7 3 94.7 4. 96.6.8 3 77.6 3.2 85.7.7 3 63.3 4.3 75.7 1.2 4 95.9 2.8 92.6 2.8 4 71.2 4.2 79. 3.1 4 56. 5.3 7.1.7 St.4 NB-1 MCF7 St.6 NB-1 MCF7 St.7 NB-1 MCF7 25. 6.6..5 25. 1.5..4 25. 3.2. 1.3 97.9 1.9 99.3 2..6 3.1 99.8 2.1.8 2.2 13..8 87.6 2. 96.1 2. 12.8 3.1 99.3 2.5 96.7 3. 14.6 1.1 2 78.6 3.7 87.7 2.3 2.9 2.1.3 2.6 2. 5.4 11.4 1.1 3 67.6 9.4 76.8 2.5 3 98.5 4.4 96.8 3.1 3 92.5 7.6 99.1 4.3 4 58.4 5.7 7.5 3.6 4 97.8 5. 94.8 4. 4 92.6 1.4 93.1.9 St.8 NB-1 MCF7 St.9 NB-1 MCF7 St.11 NB-1 MCF7 25. 6.3. 2.2 25. 7.8. 2. 25. 7.3. 4.3 96.6 4.4 11.7 2.5.4 4.1 11.2.5 94.7 3.2.1 1.7 93.6 6.5 12.4 3.2 94.4 3.5 98.2 4.3 96.2 3.9 99.4 1.2 2 88.8 3.7 97.2 2.7 2 91.9 5.7 95. 2.4 2 86.6 1.8 95.6 1.4 3 87.3.7 9.8 3.9 3 83.3 7.5 87. 5.1 3 88.8 1.7 89.4 3.1 4 81.1 4.2 86.8 3. 4 73.8 4.8 83.6 1.3 4 82.8 9. 83. 1.8 St.12 NB-1 MCF7 K NB-1 MCF7 M.Q. NB-1 MCF7 25. 4.6..6 25. 5.7. 1.4 25. 6.. 1.4 98.8 3.6.2 2.5 98.8 3.6 11. 2.1 12.1 5.7 11.9 1.9 98. 2.2 97.1 1.2 13.8 4.1 11.3 1. 99.2 5.3.6 1.8 2 94.1 3.2 95.5 1.8 2 98.5 3.1 99.9 2.5 2 97.6 2.6 12.6 1.9 3 9.9 3.2 89.5 1.9 3 11.1 8. 94.1 2.1 3 11.9 9.2 98.2.9 4 82.6 3.6 84.1 2.6 4 96.9 7.3 93. 2.4 4 76.5 4.1 98. 1.1

St.1 NB-1 MCF7 St.2 NB-1 MCF7 St.3 NB-1 MCF7 25. 4.4. 2.3 25. 2.5. 1.1 25..8. 1.1 12.6 2. 15.4 3.3 11.6 1.2.9.6 99.2 3.1 99.8 1.4 12.5 2.5 14.5 2.2 12.9 2.4 12. 2.5 97.9 2.7 11.1 2. 2.7.7 99.9 2.2 2 96.3 1.6 94.6 2.2 2 89.4 1. 91.5 2.3 3 11.4 2.7 97.9 1.6 3 93.9 3.9 92.3 2. 3 78.6.6 84.5 2.3 4 13.3 2. 99.1 1.1 4 92.4 3.9 93.8 2.4 4 77. 4.1 84.1 2.6 St.4 NB-1 MCF7 St.6 NB-1 MCF7 St.7 NB-1 MCF7 25. 1.1..7 25. 1...8 25. 3.1. 1.8 11.4 2..2.6.8 1.7 12.2 1. 98.1 2.9 98.5 1.2 98.4 2.6.4 1.4 11.4 1.1 12.5 1.4 95.5 1.5 98.8 1.6 2 95.6 1.6 93. 2.8 2 99.9 3.7.2 2. 2 95. 1.7 98.3 2.6 3 88. 4. 86.4 1.8 3 97.6 2.5 97.3.8 3 87.9 2.2 92.4 1.7 4 79.6 4.9 84.6 3.3 4 95.8 3.5 97.9 3.5 4 89.1 3.7 93.1.9 St.8 NB-1 MCF7 St.9 NB-1 MCF7 St.11 NB-1 MCF7 25. 2.7. 1.7 25. 2.7..4 25. 3.3..6 99.1 4.8.1 1.8 98.8 2.6 97. 1.2.7 3.1 12.9.8 96.3 2.9 13.1 2. 98.1 4.2 98.1 1.5 11.5.4 11.9 2.3 2 93.8 2.4 99.2 2.2 2 92.7 2.8 94.6.8 2 99.5 4.4 99.1 1.3 3 86.4 1.8 95.6 2.7 3 85.8 3.3 88. 3.1 3 92.5 2. 92.1 2.2 4 86.5 4.5 92.5 1.6 4 84.8 3. 87.6 2.1 4 89.6 3.5 92.2.7 St.12 NB-1 MCF7 K NB-1 MCF7 M.Q. NB-1 MCF7 25. 2.3. 1.5 25. 1.7. 1. 25..7. 1.6 94.2.8 11.8 1.9 98. 1.7 13.4 2.9 99.4 3.9 99.6.8 94.8 1.7 11.7 3.6 98.7 1.5 11.9 1.2.9 1.6 13. 2.4 2 93.3 3.2 99.4 3.5 2 95.4 4.3 97.8 2.1 2 98.3 1.6 11.4.9 3 86.7 5.1 9.9 1.2 3 92.8 2. 92.1 1.8 3 11.6 1.9 98.1 5. 4 85.8 1.8 92.3 2.1 4 92.9 3.7 91.6 2.4 4 89.6 3.4 96.2 1.3

St.1 NB-1 MCF7 St.2 NB-1 MCF7 St.3 NB-1 MCF7 25. 2.7. 1.3 25. 1.. 1.3 25. 1.2. 1.4.3 1.9 11.2 2.9 97.8 3.1 97.6 3.7 11.8 2.6 11.8 2.3 12.5 2.2 14.3 1.3 99.1 1.9 98.8 2.8 99.2 2.1 11.5 1.3 2 98.9 2.5.8 1.5 2 93.3 4.1 96.3 1.6 2 96.7 1.1 97.6 1.8 3 97.5 1.1 96.7 2.6 3 85.9 1.4 89.7 4.1 3 89.1 2. 92.5 2.6 4 96.4 7.9 99.9 1.8 4 85.7 3.9 93.9 1.3 4 94. 3.9 94.4 3.5 St.4 NB-1 MCF7 St.6 NB-1 MCF7 St.7 NB-1 MCF7 25. 2.6..9 25. 3.1. 1.2 25. 2.3. 1.2 99. 1.9.7 1.9 11.4 3.3 12.5 1.5.3 3.6 12.5 1.7 11.5 2.6 99.7 2.9 11. 1.6 14.1 2.4.5 4.6 12.5 2. 2 97.6 2.9 96.2.2 2 98. 1.7.9 1.6 2 99. 2.6 99.5 4. 3 92.4 2.9 92.2 1.8 3 94.2 2.8 96.9 1.5 3 91.7 5.3 91.8 3.4 4 94.3 3.3 92. 2.2 4 94.9 4.1 13.6 1.4 4 91.8 5.8 98.8 1.2 St.8 NB-1 MCF7 St.9 NB-1 MCF7 St.11 NB-1 MCF7 25. 1.5. 1.4 25. 1.8. 1.2 25. 1.5. 1.5 99.9 1.6 98.5 2.6 15.7 1...8 12.3 3.1 11.3.8 99.1 1.7.7 1.1 13.5 3.5.5 3.6.1 2.5 11.7.5 2 98.4 3.7 96.6 1.7 2.9 3.5 95.9.5 2 99.3 3.4 97.4 1.8 3 87.4 6.3 9.3 4.4 3 93.5 2.2 9.4 1.9 3 94.7 1.9 93.5 1.5 4 91.6 1.8 95.2 2. 4 91.9 2.7 91.9 1.4 4 9.4 3. 95.5.9 St.12 NB-1 MCF7 K NB-1 MCF7 M.Q. NB-1 MCF7 25. 2.7. 2.5 25. 3.9. 1.8 25. 2.2. 1.5 97.1 2.8 12.2 1.6 11.4.8.9 1.9 99.5 2.8.4 1. 95.8 1.4 12.3 1.6 98.9 1.9 11. 1.3 12.1 2.4 98.7 2.3 2 93. 3.3 99.1 1.4 2 97.2 3.2.4 1.5 2.1 1.8. 2.2 3 87.6 1.5 92.1 1.7 3 92.2 2.3 94.1 1.4 3 99.9 3.6 96.7 1.8 4 88. 3.4 97.7 2.9 4 87.9 4. 99.4 2.1 4 87.9 4. 93. 2.3