Immunological parameters such as lymphocyte subsets, blastogenesis, natural killer (NK) activity of peripheral blood lymphocytes, and serum interferon activity were investigated on 40 oral cancer patients composed of 20 good prognosi cases without metastasis (good group) and 20 bad prognosis/metastasis-positive cases (bad group). The results obtained were as follows. 1) While each lymphocyte subset proportion in good group was not significantly different from that in healthy controls, Leu3a+8+ cell proportion in bad group was significantly lower (p<0.05) than the controls', and statistically significant decreasing cells with chemo/radiotherapy was observed in good group. (p<0.001) of Leu3a+8+ 2) Lymphocyte blastogenesis was correlated with Leu3a+8+ cell proportion (p<0.001), and blastogenic response in bad group was inferior to the controls' lymphocyte response. 3) No significantly different NK activity could be observed among two patient groups and healthy controls, but serum IFN activity in good group was significantly higher than that in controls (p<0.01). From the above, it was revealed that immune condition relates with the clinical feature of oral cancer patients, and Leu3a+8+ cell proportion appears especially useful for the evaluation of the patient's status.
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