21 +
TC : Toatal Choelesterol TGtriglyceride CE : cholesterol ester VLDLvery low density lipoprotein IDLintermediate density lipoprotein LDL low density lipoprotein HDL high density lipoprotein FFAfree fatty acid NEFA Lp(a): lipoprotein(a) (a) LPLlipoprotein lipase HTGLhepatic triglyceride lipase TG CETP:cholesteryl ester transfer protein CE FHfamilial hypercholesterolemia TC
Chol (mg/dl) TG 0 C>B>A <0.96 VLDL 630 C>B>E ~1.006 LDL HDL 12140 4070 B A >C ~1.063 ~1.125 VLDL LDL HDL
LDL- LDL-C LDL-CFriedewald Friedewald400mg/dl Friedewald LDL-CHDL-C
220mg/dL LDL HDL LDL HDL 140mg/dL 40mg/dL 150mg/dL
WHO β
β
TG 83% 52.2% 49.3% b 32.4% a 16.9% n=136 1.4%,78,115,1990.
TG FFA TG TG= VLDL LPL LPL HDL VLDLsmall dense LDL
2
TGHDL-C LDL small dense LDL LDL LDL RLP-C
220mg/dL LDL HDL LDL HDL 140mg/dL 40mg/dL 150mg/dL
mg/dl LDL-C TC LDL-C HDL- C TG A B1 B2 B3 B4 0 1 2 3 4 240 220 200 160 140 120 40 150 C 180 100
B3B4 200 LDL120 HDL40 150 (120) C 180 LDL100 mg/dl
LDL-CHDL-CTG
* 50 3060/3
1 2 III
LDL-C TC TG HDL-C
ll a ll b 700mg/dl EPA
HMG-CoA LDLC TG HDLC. CYP A C A Medical View Points 22(10)2001
pleiotropic effects
LDL JAMA 2001;285:2486-2497.
cm cm mgdl HDL mgdl mmhg mg mgdl Diabetes & Endocrine Division, Kawasaki Medical School
CT
0 1 2 34 0 1 2 34 1.00 4.01.79. 8.3.023. 10.3.333. 1.00 5.1.814.5 9.72.734. 31.35.8168.9 p - 0.0011 0.0001 0.0001 p - 0.0023 0.0005 0.0001 p for linear trend p = 0.0001 p for linear trend p = 0.0001
Diabetes & Endocrine Division, Department of Medicine, Kawasaki Medical School
Diabetes & Endocrine Division, Department of Medicine, Kawasaki Medical School
µ µ µ µ Diabetes & Endocrine Division, Department of Medicine, Kawasaki Medical School
Diabetes & Endocrine Division, Department of Medicine, Kawasaki Medical School
62mm 48mm Diabetes & Endocrine Division, Kawasaki Medical School
LDLCFH atorvastatin 20mg, probcol 1000mg LDL 222115 mg/dl Diabetes & Endocrine Division, Kawasaki Medical School
Diabetes & Endocrine Division, Department of Medicine, Kawasaki Medical School
Diabetes & Endocrine Division, Department of Medicine, Kawasaki Medical School
PAGE Diabetes & Endocrine Division, Department of Medicine, Kawasaki Medical School
Diabetes & Endocrine Division, Department of Medicine, Kawasaki Medical School
LPL Diabetes & Endocrine Division, Department of Medicine, Kawasaki Medical School
LPL C 2