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6 60 etc.

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11 23.5% 2.8% 2.8% 3.4% 30.3% 9.9% 11.5% 15.8%

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17 AAN n=985 n=495 n=490 n=490 %

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20 / / -/ NIPPON DATA 80

21 / / -/ NIPPON DATA 80

22 / -/ NIPPON DATA 80

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24 UK Small Aneurysm Trial The Edinburgh Artery Study The Cardiovascular Health Study

25 COPD CT

26 COPD

27 Influenza-like disease Healthy Total Mild Moderate Severe Total smoker Number (%) non-smoker Number (%) 36 ( 60%) 47 (41.6%) 24 ( 40%) 66 (58.4%) 60 (100%) 113 (100 %) (16.7%) 18 (38.3%) 14 (38.9%) 8 (17.0%) 16 (44.4%) 21 (44.7%) 36 (100 %) 47 (100 %) Kark JD, Lebiush M. Am J of Public Health 71 :

28 Nuorti JP et al. Cigarette Smoking and Invasive Pneumococcal Disease. N Engl J Med. 2000;342: Lidia Arcavi et al. Cigarette Smoking and Infection. Arch Intern Med. 2004;164:

29 23.5% 2.8% 2.8% 3.4% 30.3% 9.9% 11.5% 15.8%

30

31 cm cm cm mmHg and/or mmhg 110mg /dl TG 150mg /dl and/or HDL-C 40mg /dl

32 GLUT-4 AT- TNF glucose GLUT-4

33 Iwashima Y, Katsuya T et.al. Hypertension Jun;45(6):

34 Hypertension Jun;45(6):

35 Foy Capri G, Bell RA et.al. Diabetes Care 28: , 2005 OGTT Findings form the Insulin Resistance Atherosclerosis Study (IRAS) Normal Glucose Tolerance N=593 Impaired Glucose Tolerance N=295

36 TNF TNF FFA Liu RH, Mizuta M, Matsukura S : J Pharmacol Exp Ther Jul;310(1):52-8

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38 HP

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40 COPD

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42 2007 :

43 10 10 Doll R, et al. BMJ 2004;328: Survival from age 35 for continuing cigarette smokers and lifelong non-smokers among UK male doctors born , with percentages alive at each decade of age Copyright 2004 BMJ Publishing Group Ltd. Age(years)

44 70 70 R. Doll et al BMJ 1994;309: Mortality in relation to smoking:40 years' observations on male British doctors

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46 Sundstrom J,et al. Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study. BMJ. 332:878-82,2006.

47

48 etc.

49 Weitzman M et al: Pediatrics Apr;85(4): Maternal smoking and childhood asthma. n= Infante-Rivard C et al: Am J Epidemiol Sep 1;150(5): Maternal smoking and childhood asthma. n=

50 n=149 < 10 / 10 / < n Morkjaroenpong V et al:j Allergy Clin Immunol 110(1): ,2002.

51 COPD HDAC HDAC Kazuhiro Ito et al: N Engl J Med 2005;353(5):528.

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53 WHO Report on the Global Tobacco Epidemic, 2008

54 FCTC Framework Convention on Tobacco Control WHO COP3 COP : conference of the parties FCCC Framework Convention on Climate Change. CO2 CO COP15

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56 N.Y. N.Y. etc. 27,000 27, ,

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58 FDA FDA WHO WHO

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61 a 0-

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64 ETS Environmental Tobacco Smoke SHS Second Hand Tobacco Smoke IARC EPA EPA IARC A

65 Pell JP et al. Smoke-free legislation and hospitalizations for acute coronary syndrome. N Engl J Med 2008;359:482-91

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67 JT 50% JT 50% JT 50.02% 2.46% 1.85% 1.51% 1.35% JT NY

68 !

69 JT JT JT JT JT JT

70 JT JT JT

71 Why Review Articles on the Health Effects of Passive Smoking Reach Different Conclusions Deborah E. Barnes et al. JAMA. 279: % %

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73 EU

74 EU

75 EU

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91 58 40 / 40 TDS 10 CO 34ppm

92 58

93 42 30 / 20 TDS 6 CO 9ppm HP JT

94 42 JT

95 25 20 / 10 TDS 9 7 CO 24 18

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98 * Merry Christmas!

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