2007 H19.8 2007 5 26 ()
2 3 7 9 12 14 15 18 25 29 1
2
() (g g kcal) mg/dl.mg/dl ( U/mlhr).(mg/dl*U/ml) 50.2 158.6cm 70.7kg 28.1kg/ 92.5cm ( ) () ( ) (.(.-.)g/ml.(-.) g/ml ((MS) MS MS cm 2 MS () 3
4 122/74 124/68 108/70 114/77 134/76 134/76 142/82 142/96 128/88 136/86
n=5 n=5 5
cm cm cm cm 6
7
Effects of Acarbose and Miglitol on plasma glucose and insulin concentrations after the test meal BS (mg/dl) IRI (microu/ml) A vs. M p=0.0016 (ANOVA) M 120 >A 120 p<0.05 (Bonferroni/Dunn) A vs. M p=0.0008 (ANOVA) M 120 >A 120 p<0.01 (Bonferroni/Dunn) Effects of Acarbose and Miglitol on peak FBF and FDR after the test meal FBF(ml/dl/min) % ** * * * * ** * Baseline 60min 120min Peak FBF Placebo Acarbose Miglitol ** * * * * * Baseline 60min 120min FDR 8
1) 2) 3) 4) 1) 2) 3) 4) 10 Cookie test 200 15 LDL-CHOIRISa FRAS 4,, MC-FANmicro channel array flow analyzermc KH-6,100l Sa Sa IGTIFG30 3 60 4 120 3 IRI 4 120 IGT 60 2 120 1 Sa 30 60 (2 )120 () HOMA-R 2.5 120 Sa Ht LDL- ( ) ()IRI 30 60 120 IRI HOMA-R 2.5 120 9
sec 90 HOMA-R;2.5< 80 70 Sa time 60 50 40 30 556.4 478.3 5810.7 5810 20 10 0 P<0.05 P<0.05 Pre 30 min 60 min 120 min Time (Sa time) (sec) p<0.05 10
(Sa time) (sec) p<0.01 mg / dl) 11
12
13
14
15
16
*** ** ** ** 17
18
19
20
DMIGTIFG BMI 21
SM 23 / 31 6 / 11 2 4 5 22
23
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key words: small dense LDL, Tel: 03-3784-8532 Fax: 03-3784-8742 E-mail: hirano@med.showa-u.ac.jp 26
1ATG)B48 TG (mg/dl) (n=38) (n=19) (n=8) ApoB48 (mg/l) (n=19) (n=38) (n=8) 0 1 2 4 6 h 2LDL phenotype, d<1.006 d<1.006(mm mm) d<1.006(mm mm) P<0.0006 3.0 Pattern A Pattern B P<0.0002 P<0.007 3.0 2.0 ns 2.0 1.0 ns 1.0 0 3 6 9 h A B 27
1. Proctor SD, Mamo JCL: Intimal retention of cholesterol derived from apolipoprotein B100- and apolipoprotein B48-containing lipoproteins in carotid arteries of Watanabe heritable hyperlipidemic rabbits. Arterioscler Thromb Vasc Biol 23:1595-1600, 2003 2. Hirano T, Oi K, Sakai S, Kashiwazaki K, Adachi M, Yoshino G. High prevalence of small dense LDL in diabetic nephropathy is not directly associated with kidney damage: a possible role of postprandial lipemia. Atherosclerosis. 141:77-85, 1998 28
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50% 10 20 30
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1) TEL: 072-700-1135 2) () TEL: 06-7650-6518 E-mail: cookie-test@abilit.co.jp 32
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