....

2030 2 Vol. 22 No. 32000

1/2 EE F FAF 60E 1970 40 25FIP 1995 503cx 60 10M5 Vol. 22 No. 32000 3

carpal tunnel syndrome entrapment neuropathy cm 4 Vol. 22 No. 32000

5 Vol. 22 No. 32000 10 2- microglobulin 1/2 1/2 night tingling 1 myxedema 2 3 double lesion neuropathy 98 98 41 night tingling41 30 21

de Quervain Tinel Tinel Tinel Phalen perfecttest Tinel90 98 Phalen83 tourniquet test60 21 median nerve compression test90 15 6 Vol. 22 No. 32000

7 Vol. 22 No. 32000 X CTMRI cm 4.5msec 3.5msec subclinical double lesion neuropathy X MRI B12 10 perfectotest) O

8 Vol. 22 No. 32000 1050 2.5ml 1290 Camitz Camitz Camitz

Entrapment neuropathy. MOOK19233-249, 1981. 341685-1687, 1983. Entrapment neuropathy. pp.205-222, 1987. pp.73-116, 1991. 10366-369, 1993. pp.285-308, 1995. 39905-911, 1996. 71171-182, 1997. 38352-28, 1997. 10 pp.214-217, 1999. Vol. 22 No. 32000 9

R 199818 160010010 10 hemodialysis, HD peritoneal dialysis, PD 28.01997 20 5539 68.12/3 HD 17.7PD 13.6 0.6 PD43.5 1995 563 HDPD 2.0PD4.5 1515.51/3 PD 19 1945HD1947 PD 1970 1983 QOL PD Vol. 22 No. 32000 11

1.5 2.5 4.25 344 395 483mOsm/kg 1.1 1.3 1.6 Na 132 meq/l K 0.0 meq/l Ca 2.5 meq/l or 4.0 meq/l P 0.0 mg/dl BUN 0.0 mg/dl Cr 0.0 mg/dl continuous ambulatory peritoneal dialysis 24 L automated peritoneal dialysis PD cycle CAPD QOL nightly peritoneal dialysis R BaxterPD R 9560 4020 601135000 34000 12 Vol. 22 No. 32000

continuous cyclic peritoneal dialysis NPD NPD NPD NPD CAPD tidal peritoneal dialysis APD 50NPD CAPD CAPD24NPD HD HD PD 200ml 20kg 100ml/ PDPD HD CAPD2L1L Na 137 meq/l137 91328177m Eq10g APDNaNa Na6090mEq/L Vol. 22 No. 32000 13

800 mg PD toxic shock shock PD PD HD PD PD D 75 high turn over bone D 25 1.0g0.25 0.5g 1,25 PTHAlp low turn over bone D 14 Vol. 22 No. 32000

6.0mg/dL 4.0 CaCa4 8.0mg/dL D 8.5mEq/L Dry weight Ca ACE 50100ng/mL HD PD 100/kg Hb 300 /kg ACE IGF-I catch-up 1997. 19981231.. 1998. Department of Health & Human Services. United States Renal Data System.1999 Annual Data Report. Maryland, US. NIH, 1999.. 1998.... 1999..,. 1999.. CAPDII.. CAPD1990. Vol. 22 No. 32000 15

ddddddddddddddddddddddddddddddddddddddddddddd ddddddddddddddddddddddddddddddddddddddddddddd Vol. 22 No. 32000 17

T TT TTT 18 Vol. 22 No. 32000

T IMHC TTIMHC TIMHC T TTT Vol. 22 No. 32000 19

DNA DNA T DNADNA DNA T 20 Vol. 22 No. 32000

,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, 10Vol.20 No.10 Vol.21 No.3 10mg20mg40mg 20mg 20mg10mg 40mg Vol. 22 No. 32000 23

24 Vol. 22 No. 32000 12 50 25 12.512 6.25 12 12

25 Vol. 22 No. 32000 36 24 24 50 24 5048 25 75 24 5012.5 2587.5 93.75 24 24120 10 36 144? 2412 48 4 1.3 12 3.4 1.0 1.3 2.0 12 3.4

3.4 1.5 26 Vol. 22 No. 32000

DI REPORT 27 Vol. 22 No. 32000 DI 50 mm 1000 2700 P 21G 25 B 505500 P 253500 21G 25475509002003000 B-D - 12180 20600mg/dL 150300mg/dL 1550L 50 20 1156218.5 100g H6. 9. 1 9700 2700 P 21G 25 2527505055002502510 5000 S P 253500 21G 25475509002003000 B-D - 40 10600mg/dL 50L 100 90.459.516.7 80g H7. 8. 7 H11. 9 2700 25 S 25275025025105000 25500 40 10600mg/dL L 100 892163 60g H11. 9. 6

DI REPORT M 1200 5000 1300 1500 25 B-D 30G25 2535003042005005000 2535003042005005000 2535003042005005000 1500195000 1500195000 1500195000 2000 2000 3300 2003200200253200 200320020025320025625 240303840 240303840 256252003300 B-D 30G255251002000 28G1002000 25500 1201600 25500 21G1002500 1201600 26G1002000 DM 15000 3000 30 30 30 20600mg/dL 20600mg/dL 20600mg/dL L L L 20 120 20 mm 51.087.014.5 56.097.814.5 87.051.014.5 45g 60g 45g H10. 11. 4 H10. 11. 4 H10. 11 28 Vol. 22 No. 32000

DI REPORT 29 Vol. 22 No. 32000 mm 5000 2535003042005005000 1500195000 3300 25625 256252003300 B-D 30G255251002000 28G1002000 21G1002500 26G1002000 3000 DM 5000 30 20600mg/dL L 120 56.097.814.5 60g H10. 11 8900 -S50 200 -S 506000 3000 2004600 90 10600mg/dL 10 1327919 150g H2. 1 6500 9800 25 25 N 2533001002000500 2500 25 3000 2003200 201000 11000 LNH 2.5mL3000 3045 10600mg/dL L 10 1126420 100g H5. 6. 7

DI REPORT 3033001202600 25325050255300300 25325050255300300 720684001440 2512680 2512680 115200 10 253400 3000 2017 4300 10 1800 Z 2003200100012000 Inc. Inc. 509502003200 3200 3200 25 25 253400 509502003200 5200 1500 10500 Z LNH 3000 CROM 6000 1500 30 30 30 10600mg/dL 500mg/dL 500mg/dL L 10L 10L 100 10 150 mm 81.366.025.4 866019 866019 80 102g 102g H9. 6 H8. 8. 26 H11. 8. 2 10 1800 H12. 2 H11. 7 30 Vol. 22 No. 32000

DI REPORT QID 4500 3000 10 9800 1500 50 9800 10135025325050 253000303600 60001001150020023000 253000303600 1000 900 2100 2100 21G1001500 28G25500 25 450 ml1250 50 8003048030480 20 18 18 20600mg/dL 20600mg/dL 20600mg/dL 3.5L L L 10 150 150 mm 974814.5 13810 1254716 1545716 40g 18g 60g 95g H10. 10. 12 H11. 5. 1 H.11. 4. 6H9. 3. 12 H11. 9. 2 121 H10. 10 H11. 2 H12. 1 H9. 6 H9. 2 H9. 2O/T No.321996 1996325 97 PRACTICE Vol. 15 No. 2 1998. 3. 4 Vol. 22 No. 32000 31

4B 12 4B 32 Vol. 22 No. 32000

365427 NHK 1973 Vol. 22 No. 32000 33

N.I.Vavilov 20 F.N.Meyer Augustin Pyrame de Candolle17781841 1883 1565 1993 712 673686 7941192 1739 34 Vol. 22 No. 32000

1712 21 178122 to-mo to-mo 1969 1994 Prunusplum persica Perusicum mālum Persicum presica pesca peschepeche pêche peche14peach16 Vol. 22 No. 32000 35

peach peche PfirsichPfirsichbaum Pesca Prunus persica(l.)batsch (Amygdalus persica L.) m 15cm 1.5cm 2.53.5cm 10 10 1681 1873 1875 kaempferol cumarin amygdalin24-24-methylencycloartanol 7-7 -avenasterol40 emulsin 1712 g 30g 500g 36 Vol. 22 No. 32000

1318 Vol. 22 No. 32000 37

1876 261893 431910 261951 10 38 Vol. 22 No. 32000

39 Vol. 22 No. 32000 11 11 15 13 14 52

1971 5011 30 TEL 03-3719- 8111 40 Vol. 22 No. 32000

OK 40OK OK OKOK OK Vol. 22 No. 32000 41

42 Vol. 22 No. 32000 21

43 Vol. 22 No. 32000 PR A 12 OTC 10 OTC 3040

44 Vol. 22 No. 32000 21 DI TDM TDM

45 Vol. 22 No. 32000 TDM 480 1,500 G 100 3050 OTC100 OTC 100

46 Vol. 22 No. 32000 OTC OTC OTC 1020 OTCH2 70 H2 OTC OTC 10 865563 10 1020 30

47 Vol. 22 No. 32000 TDM TDM TDM TDM 10 EBM

48 Vol. 22 No. 32000 OTC 21 10

49 Vol. 22 No. 32000 AB

50 Vol. 22 No. 32000 21

50 Vol. 22 No. 32000 51

15202570 27.41998 33.1 202559.0 3040 28.216.8 11.4 200 QOL 10 104036 365 149.3 1012 CAPD 56.9 52 Vol. 22 No. 32000

53 Vol. 22 No. 32000 78.865 63.2 45.0 JA 56.4BC 43.6 13.5 13.0 37.421.516.6 43.0 10 18 80 23.1 25 47 23

54 Vol. 22 No. 32000 86.757.2

55 Vol. 22 No. 32000 92.6 81.475.9 64.4 23 1/4 14

Col N. et al : The role of medication noncompliance and adverse drug reaction on hospitalizations of the elderly. Arc Intern Med. 150 : 841845, 1990 19994612 p. 217 Lamy PP. : Adverse drug effects. Clin Geriatr Med. 6 : 293307, 1990 J Okuno et al. : Compliance and medication knowledge among elderly Japanese home-care recipients. Eur J Clin Pharmcol. 55 : 145149, 1999 56 Vol. 22 No. 32000

100 22 65 100 22 Vol. 22 No. 32000 57

58 Vol. 22 No. 32000 103 37 76

59 Vol. 22 No. 32000 62 ;; ;; ;; ;; ;; ;; ;; ;; ;;;;;;;; ;;;;;;;; ;;;;;;;; ;;;;;;;; ;;;;;;;; ;;;;;;;; ;;;;;;;; ;;; ;;; ;;; ;;; ;;; ;;; ;;; ;;;;; ;;;;; ;;;;; ;;;;; ;;; ;;; ;;; ;;; ;;; ;;; ;;; ;;;;;;; ;;;;;;; ;;;;;;; ;;;;;;;

60 Vol. 22 No. 32000 10 10 a b c d 10 QOL

61 Vol. 22 No. 32000 QOL OTC ;;;;;;;; ;;;;;;;; ;;;;;;;; ;;;;;;;; ;;;;;;;; ;;;;;;;; ;;;;;;;; ;;; ;;; ;;; ;;; ;;; ;;; ;;;

532-38 1998 117 1997 1990 3359-641991 29 1996 1998 62 Vol. 22 No. 32000

65 Vol. 22 No. 32000 417 2-4-36 JR10 1,350 3-3-20 JR10 3,000 900 1-6-17 790 1-12-10 JR ;; ;; ;; ;; DDDDDD DDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDD

66 Vol. 22 No. 32000 122146 12 13 14 15 16 18 19 20 22 24 25 26 27 28 29 31

68 Vol. 22 No. 32000 13 PI9923 12 1020 12 13 1012161112 1502 1010 32 111112 11101130 12 13 14 15 16 43 17127,941 18 12 12 11 YMCA 13 18 19 20 21 26 27

69 Vol. 22 No. 32000 12 27 Na 11211030 85 2526 11 2223 1213 10 11 12 1312 14 13 10 1112 11 Q&A 2,079 1222NKS Tel03-3294-0271

70 Vol. 22 No. 32000 22390 300 101-0054 1 21 132940271 2,000 9025-53-1 12 JR10 JR10 JR 21