PET ( TIAN Mei )
PET 100 PET
PET PET PET
PET
Positron Emission Tomography (PET) PET Positron Emission Tomography CT
PET FDG
Glucose and 18 F-FDG 18 F-FDGFDG CH3OH O CH3OH O OH OH OH OH OH OH OH 18 F *FDG 18F-FDG - - - -D- 18-F
FDG
PET PET 110
PET
Positron emitters for clinical PET scanning Isotope Half-life Fluorine: 18 F Carbon: 11 C Oxygen: 15 O Nitrogen: 13 N 110 min 20 min 2 min 10 min
Biochemical and physiological processes visualized by PET Mechanism PET tracers Glucose utilization FDG Phospholipid metabolism Choline Amino acid transport Methionine and metabolism FAMT Proliferation Thymidine, FLT Apoptosis Annexin V Blood flow H 2 O Hypoxia FMISO Bone Metabolism Sodium fluoride
Mechanism of PET tracers Glucose utilization Phospholipid metabolism Amino acid transport and metabolism Proliferation Apoptosis Blood flow Hypoxia Bone Metabolism
Glucose utilization FDG Cellular uptake of FDG through glucose transporters and phosphorylation by hexokinase Widespread established clinical usages including staging, assessment of response, and detection of recurrence
Phospholipid metabolism 11 C-Choline, 18 F-Choline Cellular uptake of labeled choline through specific receptors and phosphorylation by choline kinase. Endogenous choline is subsequently involved in synthesis of membrane phospholipids. Evaluation of prostate tumors and breast cancer
Brain Tumor A 58-year-old male with glioblastoma in the right frontal lobe. (A) MRI image showed a ring-enhanced tumor in the right frontal lobe. (B) 11 C- Choline PET demonstrated high 11 C-Choline uptake (SUV = 4.4). (C) FDG-PET showed significant high accumulation (SUV = 10.1).
Phospholipid metabolism 11 C-acetate Mechanism of uptake incompletedly understood. Thought to be involved in synthesis of phosphatidylcholine and other lipids Evaluation of prostate tumors and breast cancer
Advanced prostate cancer 18 F-FDG 11 C-acetate Multiple osseous metastases (arrows) were better visualized with 11 C- acetate PET than with 18 F-FDG PET.
PET PET PET
PET PET X CT MRI PET PET
PET CT PET
PET PET
FDG-PET
Normal FDG PET Image
Normal FDG PET Image
Lung cancer
FDG FDG
FDG-PET 2
FDG-PET 90 81 100 80 78 94 90 80 94 BAC) 10mm FDG CT FDG
PET FDG-PET PET FDG-PET
PET FDG-PET PET FDG-PET
CHOP RI CD20 (Y) 90 CD20
FDG-PET MALT T Castlemen s disease CT MRI FDG
FDG-PET 5mm FDG BAC)
PET
PET CT mm
PET PET PET
C T + P E T
CT PET
CT-PET
PET RI CT 100g MRI 10g RI g g PET (Molecular Imaging) cf: CT 0.1 0.2mm