2 Vol. 20 No. 101998
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ADHD Attention-Deficit/Hyperactivity Disorder 104.5 13 4 Vol. 20 No. 101998
1920 1930 1937 DSMDiagnostic and Stastical Manual of Mental Disorders,Fourth Edition WHOICD10International Classification of Diseases,Tenth Edition DSM ADHD ICD10 DSM MBDMinimal Brain Dysfunction LDLearning Disabilities MBD Soft Neurological Sign LD Vol. 20 No. 101998 5
6 Vol. 20 No. 101998
ADHD 4090 3050 ADHD positive spike WISCRWechsler Inteligent Scale for Child 1025 ITPAIlinois Test of Psycholinguistic Abilities ADHD Vol. 20 No. 101998 7
8 Vol. 20 No. 101998 3070 ADHD carbamazepine haloperidol methylphenidate dextro-amphethaminepemoline 20mg/
9 Vol. 20 No. 101998 48ADHD ADHD ADHD 37
10 Vol. 20 No. 101998 ADHD90 ADHD LD FDA 30 40
11 Vol. 20 No. 101998 10
12 Vol. 20 No. 101998 10 Citrobacter Ballerup 20635 24.9114.0 g/g 24.967.2g/g36.7114.0g/g 24.049.3 g/g 20 14 0.20.3g/g 20g/g 600g/g
13 Vol. 20 No. 101998 1991 131.5 P.zeylanica Peh 40 19891022Mt Fuji 1985 1989
Biosphere 1993 5 No.6 14 Vol. 20 No. 101998
1 QOL QOL QOL coping 60707090 Vol. 20 No. 101998 17
27 11 22 4 65 14 28 4 70 80 65 90 60 70 60 80 NLP 20 41 NLPSST 20 20 NLPFT 21 19 NLPSSTFT 20 0 1987 Blankenburg 1982 noncompliant McGhie & Chapman1961 Dawson & Nuechterlin 1984 1994 Grossman L & Summers F198020 60 15 18 Vol. 20 No. 101998
19 Vol. 20 No. 101998 1998 1996 1995 MOOK 1989 MYW1997 1997 1998 1996 R. P. 1993
80 90 20 90 51 50 ICD10F20. X 22 BPRSDIEPSS QOL 63318551995 161163 1995 50951419011996 9610321994 Johnson DAWObservation no the use of long-acting depot neuroleptic injections in the maintenance therapy of schizophrenia. J. Clin. psychiatry 45 (5)13211984 Hogaty GE, Andeson CM, Reiss DJ et al Famity Psychoeducation, Social Skills, and maintenance Chemotherapy in Aftercare Treatment of Schizoprenia. Arch Gen psychiatry 436336421986 p52611998 9810051996 9810051996 20 Vol. 20 No. 101998
,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, T.Theorell 1937 Theorell Vd Kel Theorell Vol. 20 No. 101998 21
22 Vol. 20 No. 101998 Vd Vd t1/2 t1/2 1.11426 1966 Bishoff
23 Vol. 20 No. 101998 HIV 2001000mg X tx Xt t
t Xt dx/dt Kel dx KelX dt dx/dt dx/dty y=ax X XXe Kelt e Kelt 2,700 Vd XVdC XXe Kelt VdCVdCe Kelt Vd CCe Kelt 1.1 C Ct C 3.0ng/ml X100 e Kelt e Kelt e Kelt e 2.718Kel 24 Vol. 20 No. 101998
e Kelt CCe Kelt C e Kelt e Kelt C e Kelt e Kelt Fac accumulation factor e Kelt Css.max e Kelt e Kelt e Kelt Css.maxVd Dosee Kel FS 1.2 1.3 1.4 S Kel DoseCss.maxVd/FS e Kel F 1001.0S 1001.0 Css.maxVd FS Css.maxVd/FS Dose DI Dose Css.max Vd F Vol. 20 No. 101998 25
1998.10 Drug Information 1996.12 The 3rd Edition of Michael E. Winters BASIC CLINICAL PHARMACOKINETICS Applied TherapiuticsInc. 11 12 123000 50 86 10 50 26 Vol. 20 No. 101998
ZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZZ 86 72 365 18 Vol. 20 No. 101998 29
2.5 2T T. T 74 1/2T O2 Y. Y 92 L10 1T 25 3T 90100/5060 QOL O. K 73 25 2T 1/2T 1T L20 2T R 2P 3T 100 3P 30 3T 2.5 6T 1T 4T 0.5 1T TTS K. M 70 S 2.0 2.0 3T 3T 100 4T-- 250 4T-- 2T 10 30 Vol. 20 No. 101998
H. M 83 S 2.0 2P 25 2T 20 2T 2.5 6T 100 3P 100 3T 1.9 K. T 73 23 1 2 3 1 2 3 MSWPTOT 14 14 Vol. 20 No. 101998 31
32 Vol. 20 No. 101998 QOL PTOT PT OTMSW QOL ADL QOL
581619 Vol. 20 No. 101998 33
25220 10 1926 20 712 Zanthoxylum xanthos xylon piperitum Japanease PepperPoivre japonais Zanthoxylum piperitum De Candolle 15 3.5 34 Vol. 20 No. 101998
Z. piperitum DC. f. inrme Makino 1928 Z. piperitum DC. f. Z. piperitum DC. f. brevispinum Makino Z. armatum DC. var. subtrifoliatum Kitam. Z. alatum Roxb. var. pianispinum Rehd. et E. H. Wils. Z. planispinum Sieb. ex Zucc. m 10 1961 No.1239 Fagara mantchurica Honda Z. schnifolium Sieb. et Zacc. Vol. 20 No. 101998 35
g No.1240 Z. bungeanum Maxim. m limonene 1997 1995 tt Z. simulans Hance m 10 m Citoronellaldllimonener--Phellandrene GeraniolCitronellol --Sanshoöl --Sanshoöl-- Hydroxy--Sanshoöl-- Hydroxy--Sanshoöl -Sanshoölall-trans-Sanshoöl QuercitrinAfzelinHesperidin 36 Vol. 20 No. 101998
gg Vol. 20 No. 101998 37
27 ADL 85 14 97 85 19 1021 Vol. 20 No. 101998 39
85 9697 97 40,80 30,70375.3 9,45923.26391.6 100 15 1029 22 40 Vol. 20 No. 101998
18 10 11 94 79 10 10 11 417079 Vol. 20 No. 101998 41
NPO 12) 12 non-profit-organizationimidas 98 NPO NPONPO 42 Vol. 20 No. 101998
PL 1 Clinical Pharmacy 1960 2 Vol. 20 No. 101998 43
3 10305 14547.5 7825.5 12 3.9 7022.9 4 5 1218 44 Vol. 20 No. 101998
45 Vol. 20 No. 101998 300 33.839.713.2 7.04.0 97 QOL 10 11 12
71.4 13.3 14.7 72.4 11.0 16.5 65.1 10.3 24.3 62.1 11.8 25.7 71.3 7.4 21.3 78.7 7.0 14.0 40.8 23.5 35.7 74.6 5.5 19.9 73.5 7.7 18.4 72.8 7.7 33.1 77.1 6.3 15.8 75.4 5.5 18.4 48.1 13.9 36.8 75.4 7.3 16.5 64.7 12.5 21.3 300 40.8 46 Vol. 20 No. 101998
117 30 Vol.20, No.5, 21998 Vol.31, No.10, 12201995 Vol.46, No.10, 14651994 1986 Vol.19, No.9, 91997 Vol. 20 No. 101998 47
From Kuraya Drug Information Center 48 Vol. 20 No. 101998
Vol. 20 No. 101998 49
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^ 10/ 10/21 600 6103-3499-3388 1,000 103-3785-3858 FAX03-3787-1325 2-2-1 1 10/17 11/28 10,000 1 Vol. 20 No. 101998 55
56 Vol. 20 No. 101998 18 1874 800 600 500 1045 400660 200250 300400 600 10 11 300 30059 35 12 20 130 25
57 Vol. 20 No. 101998 450500 44 500 100 520 2635 100200
19 26 27 30 102728 49!! 30 TO SEE IS TO BELIVE 58 Vol. 20 No. 101998
E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D E F G A B C D Vol. 20 No. 101998 61
62 Vol. 20 No. 101998 NaN3 LDL046mg/kg LDL030mg/kg LDL035mg/kg LD50 18mg/kg LDL012mg/kg 0.65 1.3mg0.01 0.02mg/kg 1015 30 0.653.9mg 15 NaNa CNKCNNaCN HCNLDL00.57mg/kg 50100mg KCN150200mg NaCN200300mg KCNNaCNHCN 5,000 100% 1530/ Na Na10ml 25Na50ml10 25KGNa
63 Vol. 20 No. 101998 10mg/kg 10 Na125ml10 Na 10 As4AsO3AsCl3AsH3 AsO3LD501.43mg/kg 60120mg AsH3TDL00.11mgAs/kg SH 3060 12 10 70 Mg30g 200mlP BAL100mg/A 2.5mg/kg10Na10ml g Na5g 1996 1977 133981998 1990 1991 37 LDL0 LD50 50 TDL0
64 Vol. 20 No. 101998 20 mg 30mg 498 15 300 130 301030 10 11 10 12 18 19 20 21 22 23 26
65 Vol. 20 No. 101998 13 14 151026 16 1812 1910 20 21 22 23 24 25 107,883 24 Q&A 28 18 27 14 5212flecainidflecainido 14flubiprofenflurbiprofen 5312 15399392 14FU UF 13142442 11 5412 5612methimazolethiamazole
101030 66 Vol. 20 No. 101998 31 10 ADHD 102010373 300 101-0054 1 21 132940271 2,000 YMCA YMCA JR